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Establishing the identity of a person is important in the field of forensic odontology. This field can be helpful in identifying charred corpses in cases involving intense heat. Bones and body tissues can be extremely damaged due to heat, in such cases dental records have become a reliable source of identification. Dental Identification of charred human remains begins with the examination of dental features such as teeth anatomy, morphology, dental implants, oral health, restorations, fillings, dental anomalies and overall dental structure. These features remain resistant to extreme heat and can thus be compared with that of the ante-mortem records. When the postmortem and ante-mortem records match a successful identification is done. Dental features may also be damaged and become less effective for identification when temperatures rise above a particular range. In order to help with the identification of charred human remains, this research intends to give forensic experts a clear understanding of the circumstances in which dental records can be used by examining the effects of extreme temperature within the 400--800°C range. By gaining insights into this particular range and its effects on dental tissues and records gives forensic experts a chance to solve complex cases involving burned corpses. [ABSTRACT FROM AUTHOR]

This article, titled "Comprehensive Genomic Characterization of 1,200 Samples across 25 Cancer Types of Indian Ethnicity," discusses the lack of ethnic diversity in large-scale genomic projects and aims to fill this gap by conducting genomic characterization of 1,200 Indian patient samples across 25 cancer types. The study utilizes whole exome and whole transcriptome sequencing and develops an integrated genomics analysis pipeline. The results provide insights into cancer driver alterations, therapeutic targets, microsatellite instability, tumor mutation burden, and molecular subtypes specific to the Indian cancer cohort. The study also identifies novel deleterious mutations and highlights the potential for further ethnic-specific biological studies and clinical trials. [Extracted from the article]

Background: Psychological Autopsy is basically done in order to understand the cause of death in equivocal and suicide death cases. It involves collecting information about the individual's life history, mental health history, and circumstances leading up to their death in order to gain insights into the complex factors that may have played a role. Methods: The main aim of this study is to find the prevalence of Psychological Autopsy (PA) in India and to know how frequently is it being used as a means of investigation through close ended questionnaire of academicians, forensic psychologists, practitioners and trainees in the field of mental health, this study seeks to discover outcomes. Conclusion: The fact that the majority of mental health professionals had never heard the phrase psychological autopsy, despite the fact that they had used it, was a significant weakness of this study. [ABSTRACT FROM AUTHOR]

The current world energy crisis and increasing greenhouse gas emissions demand a shift from fossil-based fuels to alternative and sustainable biofuels. The innate potential of microalgae over traditional terrestrial feedstocks to provide a high-quality and sustainable fuel portfolio has been recognized. Microalgae are known to mitigate atmospheric CO2 and convert it to valuable metabolites and bioactive compounds. The high growth rate of microalgal biomass with no additional requirements of feed and arable land makes microalgae as realistic alternative to existing biofuels sources. Micro-algae can store more primary metabolites under abiotic stress, which can be used as a possible source of energy. These metabolite storing abilities of microalgae have become a point of interest for the scientific community as the accumulated lipids serve as potential feedstock for biodiesel production by transesterification, whereas the carbohydrates can be used as the feedstock for bioethanol production by fermentation. Although microalgae-based biofuels are viable sources of energy, their commercialization and deployment in the fuel market remain a challenge. As a result, efforts are being undertaken to make it more cost-effective. This review describes the microalgae biorefinery method for producing biofuel along with its commercial potential, latest research updates in biofuel research, strategies to improve the algal metabolite content along with the limitations of using algal biomass for biofuels with possible solutions to overcome those limitations. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to understand the impact of population diversity and geographic variation on tumor mutation burden (TMB) scores across cancers and its implication on stratification of patients for immune checkpoint inhibitor (ICI) therapy., Materials and Methods: This retrospective study used whole-exome sequencing (WES) to profile 1,233 Indian patients with cancer across 30 different cancer types and to estimate their TMB scores. A WES-based pipeline was adopted, along with an indigenously developed strategy for arriving at true somatic mutations. A robust unsupervised machine learning approach was used to understand the distribution of TMB scores across different populations and within the population., Results: The results of the study showed a biphasic distribution of TMB scores in most cancers, with different threshold scores across cancer types. Patients with cancer in India had higher TMB scores compared with the Caucasian patients. We also observed that the TMB score value at 90th percentile (predicting high efficacy to ICI) was high in four different cancer types (sarcoma, ovary, head and neck, and breast) in the Indian cohort as compared with The Cancer Genome Atlas or public cohort. However, in lung and colorectal cancers, the TMB score distribution was similar between the two population cohorts., Conclusion: The findings of this study indicate that it is crucial to benchmark both cancer-specific and population-specific TMB distributions to establish a TMB threshold for each cancer in various populations. Additional prospective studies on much larger population across different cancers are warranted to validate this observation to become the standard of care.

Migraine (Mg) is a multifaceted neurovascular disorder caused by genetic and several environmental etiologies. We have implemented a case-control study of TNFα gene polymorphism in 212 Mg patients and 218 healthy controls utilizing the ARMS-PCR technique, followed by Sanger sequencing. Besides, we have conducted a meta-analysis of different genetic models (five genetic models) to combine and summarize the available data from 11 studies (including this present research). The strength of genetic associations in the meta-analysis used to assess by the pooled odds ratio (OR) and 95% confidence intervals (CI). The results of this case-control study discovered a significant relationship with Mg in recessive and homozygous genotype with OR = 2.35 (95% CI [0.96-5.74]), p -value = 0.045. Also, the outcomes of meta-analysis suggested an irrelevant relationship between TNFα gene ( rs1800629 ) polymorphism and Mg susceptibility in the five genetic models. However, subgrouping based on ethnic background showed a significant association in the allelic genetic model with OR = 1.53 (95% CI [1.02-2.31]), p = 0.040 respectively. The meta-analysis results of TNFα gene polymorphism may represent a risk factor for Mg among Asians. In the future, large scale, multicentric case-control study by classification of patients with Mg with or without aura can be performed worldwide to identify the potential genetic risk factors leading to Mg pathogenesis., (© 2021 The Author(s). Published by BRI.)