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Your search keyword '"Sasan Razmjoo Ghalaee"' showing total 2 results
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2 results on '"Sasan Razmjoo Ghalaee"'

1. The comparison between effect of chemoradiation with weekly cisplatin with or without celecoxib in treatment of nasopharyngeal carcinoma: A phase III clinical trial

Author

Mohamad Mohammadianpanah, Sasan Razmjoo Ghalaee, Bijan Khademi, Amin Shafizadeh, Shapour Omidvari, Ahmad Mosallaei, Niloufar Ahmadloo, and Mansour Ansari

Subjects
Celecoxib, Chemotherapy, Nasopharyngeal carcinoma, Radiotherapy, Response rate, Otorhinolaryngology, RF1-547
Abstract

Introduction: Concurrent cisplatin-based chemoradiation is currently considered the treatment of choice for locoregional nasopharyngeal carcinoma. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor which can potentially enhance the effect of radiotherapy. The aim of this study was to determine the efficacy and safety of celecoxib in nasopharyngeal carcinoma. Materials and Methods: Patients with newly diagnosed locoregional nasopharyngeal carcinoma were included in this clinical trial study. The patients were assigned to receive 7 weeks concurrent chemoradiation with weekly cisplatin and either celecoxib 100 mg twice daily or placebo. After completion of chemoradiation, all patients received combined chemotherapy with cisplatin plus 5-Fu every 3 weeks for 3 cycles. Clinical response rates and treatment-related toxicity were the primary and secondary end-point of the study. Results: Total of 50 eligible patients with the median age of 43 years were enrolled in the trial. Overall (complete and partial) clinical response rate was 100% in both groups. Complete and partial clinical response rates were 64% and 36% in study group and 44% and 56% in control group respectively (P>0.25). There was no difference in terms of treatment-related toxicity rates between two groups. Conclusions: This clinical trial showed that addition of celecoxib 100 mg twice daily to concurrent chemoradiation does not increase the response rates and treatment-related toxicities in patients with locoregional nasopharyngeal carcinoma.

Published
2009

2. Analytical approach for determining beam profiles in water phantom of symmetric and asymmetric fields of wedged, blocked, and open photon beams

Author

Davood Khezerloo, Mohamad Javad Tahmasebi Birgani, Shole Arvandi, Mansoor Zabihzadeh, Nahid Chegeni, and Sasan Razmjoo Ghalaee

Subjects
Field (physics), media_common.quotation_subject, Dose distribution, Asymmetry, Wedge (geometry), Square (algebra), Imaging phantom, Humans, Computer Simulation, Radiology, Nuclear Medicine and imaging, Radiometry, Instrumentation, media_common, Physics, Photons, Radiation, Phantoms, Imaging, Radiotherapy Planning, Computer-Assisted, Water, Radiotherapy Dosage, Symmetry (physics), Computational physics, Particle Accelerators, Monte Carlo Method, Algorithms, Beam (structure)
Abstract

Nowadays, in most radiotherapy departments, the commercial treatment planning systems (TPS) used to calculate dose distributions needs to be verified; therefore, quick, easy-to-use, and low-cost dose distribution algorithms are desirable to test and verify the performance of the TPS. In this paper, we put forth an analytical method to calculate the phantom scatter contribution and depth dose on the central axis based on the equivalent square concept. Then, this method was generalized to calculate the profiles at any depth and for several field shapes - regular or irregular fields - under symmetry and asymmetry photon beam conditions. Varian 2100 C/D and Siemens Primus Plus linacs with 6 and 18 MV photon beam were used for irradiations. Percentage depth doses (PDDs) were measured for a large number of square fields for both energies and for 45° wedge, which were employed to obtain the profiles in any depth. To assess the accuracy of the calculated profiles, several profile measurements were carried out for some treatment fields. The calculated and measured profiles were compared by gamma-index calculation. All γ-index calculations were based on a 3% dose criterion and a 3 mm dose-to-agreement (DTA) acceptance criterion. The γ values were less than 1 at most points. However, the maximum γ observed was about 1.10 in the penumbra region in most fields and in the central area for the asymmetric fields. This analytical approach provides a generally quick and fairly accurate algorithm to calculate dose distribution for some treatment fields in conventional radiotherapy.

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