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453 results on '"Sasaki, Takeo"'

8. What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study

Author

Sasaki, Takeo, primary, Yahata, Kenzo, additional, Isomura, Minetaka, additional, Ohashi, Isao, additional, Fukuyama, Takashi, additional, Miyashita, Yusuke, additional, Watanabe, Yuzo, additional, Murai, Norio, additional, Matsuda, Masaaki, additional, Kamada, Atsushi, additional, Kaburagi, Yosuke, additional, Kira, Kazunobu, additional, Iso, Kentaro, additional, Sato, Yuki, additional, Matsuura, Fumiyoshi, additional, Matsumoto, Yasunobu, additional, Azuma, Hiroshi, additional, Iida, Daisuke, additional, Ishida, Tasuku, additional, Itano, Wataru, additional, Nagao, Satoshi, additional, Seki, Masashi, additional, Yamamoto, Akihiko, additional, Yamamoto, Yuji, additional, Yoneda, Naoki, additional, Matsukura, Masayuki, additional, Asano, Osamu, additional, Kayano, Akio, additional, Tagami, Katsuya, additional, Owa, Takashi, additional, and Kishi, Yoshito, additional

Published
2024
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10. Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials

Author

Kaburagi, Yosuke, primary, Kira, Kazunobu, additional, Yahata, Kenzo, additional, Iso, Kentaro, additional, Sato, Yuki, additional, Matsuura, Fumiyoshi, additional, Ohashi, Isao, additional, Matsumoto, Yasunobu, additional, Isomura, Minetaka, additional, Sasaki, Takeo, additional, Fukuyama, Takashi, additional, Miyashita, Yusuke, additional, Azuma, Hiroshi, additional, Iida, Daisuke, additional, Ishida, Tasuku, additional, Itano, Wataru, additional, Matsuda, Masaaki, additional, Matsukura, Masayuki, additional, Murai, Norio, additional, Nagao, Satoshi, additional, Seki, Masashi, additional, Yamamoto, Akihiko, additional, Yamamoto, Yuji, additional, Yoneda, Naoki, additional, Watanabe, Yuzo, additional, Kamada, Atsushi, additional, Kayano, Akio, additional, Tagami, Katsuya, additional, Asano, Osamu, additional, Owa, Takashi, additional, and Kishi, Yoshito, additional

Published
2024
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20. A landmark in drug discovery based on complex natural product synthesis

Author

Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Abe, Takanori, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, and Kishi, Yoshito

Published
2019
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29. Photo-induced change in alignment of mesogens using reduction of viologens as a trigger.

Author

Arai, Satoshi, Kawahara, Mikihiro, Le, Khoa V., Sasaki, Takeo, and Naka, Yumiko

Subjects
MESOGENS, LIQUID crystals, VIOLOGENS, OPTICAL materials, REFRACTIVE index, NEMATIC liquid crystals
Abstract

Liquid crystals (LCs), whose refractive index can be changed by light irradiation, can be used as photoresponsive optical materials. In this study, an LC viologen was proposed as a novel photoresponsive compound that induced a change in the alignment of LC molecules (mesogens). An extended viologen with an asymmetric core, that exhibits a low-order LC phase at room temperature, was mixed with the well-known nematic LC compound (5CB) to prepare homogeneously aligned films. The change in the alignment of the mesogens was successfully induced by triggering a one-electron reduction reaction of the viologen moieties by light irradiation. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Reading aloud and arithmetic calculation improve frontal function of people with dementia

Author

Kawashima, Ryuta, Okita, Katsuo, Yamazaki, Ritsumi, Tajima, Nobumoto, Yoshida, Hajime, Taira, Masato, Iwata, Kazuki, Sasaki, Takeo, Maeyama, Katsujiro, Usui, Nobuo, and Sugimoto, Koji

Subjects
Oral reading -- Research, Oral reading -- Health aspects, Dementia -- Research, Dementia -- Care and treatment, Health, Seniors
Abstract

Background. Recent findings of neuroimaging studies indicate that reading aloud and arithmetic calculation activate bilateral dorsolateral prefrontal cortex of humans. The purpose of this study was to measure the effect of reading aloud and arithmetic calculation, by elderly people who were clinically diagnosed with dementia Alzheimer type, on their brain functions and activities of daily living. Methods. Sixteen experimental and 16 age- and Mini-Mental State Examination score-matched control subjects participated, The participants in the experimental group were asked to perform a training program using learning tasks in reading and arithmetic for 2-6 days a week. The function of the frontal cortex of the subjects was assessed by FAB at bedside (Frontal Assessment Battery). Results. After 6 months of training, the FAB score of the experimental group showed a statistically significant improvement. The FAB score of the control group decreased slightly over the 6-month period, and the difference between the scores of the experimental and control groups was statistically significant. We also observed the restoration of communication and independence in the experimental group. Conclusion. Our results indicate that learning tasks of reading aloud and arithmetic calculation can be used for cognitive rehabilitation of dementia patients.

Published
2005

40. Influence of the laser incidence conditions on the spontaneous polarization reorientation photorefractive effect of ferroelectric liquid crystals

Author

Sasaki, Takeo, Mochizuki, Oki, Noborio, Kazunori, and Nakazawa, Yukihito

Subjects
Chemistry, Physical and theoretical -- Research, Laser beams -- Usage, Liquid crystals -- Optical properties, Chemicals, plastics and rubber industries
Abstract

The photorefractivity of a ferroelectric liquid crystal (FLC) mixed with a photoconductive compound has been investigated. FLCs have been anisotropic media, so that laser beam incidence conditions strongly affect the formation of the refractive index grating.

Published
2004

43. Influence of the properties of ferroelectric liquid crystals on the spontaneous polarization reorientation photorefractive effect

Author

Sasaki, Takeo, Katsuragi, Atsushi, Mochizuki, Oki, and Nakazawa, Yukihito

Subjects
Photoconductivity -- Methods, Polarization (Electricity) -- Methods, Liquid crystals -- Electric properties, Liquid crystals -- Properties, Chemicals, plastics and rubber industries
Abstract

The photorefractivity of 14 ferroelectric liquid crystals (FLCs) mixed with a photoconductive compound was investigated by two-beam coupling experiments. It was found that the photorefractive two-beam coupling gain coefficients and the refractive index grating formation time are strongly dependent on the properties of FLCs.

Published
2003

45. Abstract 4179: E7130 derived from total synthesis of halichondrin as a novel tumor-microenvironment ameliorator

Author

Kawano, Satoshi, primary, Abe, Takanori, additional, Ito, Ken, additional, Yahata, Kenzo, additional, Kira, Kazunobu, additional, Akagi, Tsuyoshi, additional, Asano, Makoto, additional, Iso, Kentaro, additional, Sato, Yuki, additional, Matsuura, Fumiyoshi, additional, Ohashi, Isao, additional, Matsumoto, Yasunobu, additional, Isomura, Minetaka, additional, Sasaki, Takeo, additional, Fukuyama, Takashi, additional, Miyashita, Yusuke, additional, Kaburagi, Yosuke, additional, Yokoi, Akira, additional, Asano, Osamu, additional, Owa, Takashi, additional, and Kishi, Yoshito, additional

Published
2020
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46. Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator

Author

Abe, Takanori, primary, Kawano, Satoshi, additional, Ito, Ken, additional, Yahata, Kenzo, additional, Kira, Kazunobu, additional, Akagi, Tsuyoshi, additional, Asano, Makoto, additional, Iso, Kentaro, additional, Sato, Yuki, additional, Matsuura, Fumiyoshi, additional, Ohashi, Isao, additional, Matsumoto, Yasunobu, additional, Isomura, Minetaka, additional, Sasaki, Takeo, additional, Fukuyama, Takashi, additional, Miyashita, Yusuke, additional, Kaburagi, Yosuke, additional, Yokoi, Akira, additional, Asano, Osamu, additional, Owa, Takashi, additional, and Kishi, Yoshito, additional

Published
2020
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50. Enhancement of photorefractivity in the isotropic phase of polymer liquid crystals

Author

Sasaki, Takeo, Goto, Masatomo, Ishikawa, Yuichi, and Yoshimi, Takeshi

Subjects
Liquid crystals -- Analysis, Polymers -- Optical properties, Photorefractive materials -- Evaluation, Chemicals, plastics and rubber industries
Abstract

Two-beam coupling experiments were carried out in examining the photorefractivity of the isotropic phase of polymer liquid crystals with 4-nitrobenzylideneaniline and cyanobiphenyl moieties. The polymers NBA6, NBA11, NBA3 and Ac-NBA6 were used in the study. Results indicated that a diffraction efficiency of 65% is obtained when an external electric field of 37 V/micrometer was applied in the isotropic phase of the polymer liquid crystal. The photorefractivity was higher in the isotropic phase of the liquid crystalline polymers than that for amorphous polymers.

Published
1999

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