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2. 感情開示が被害者非難の減少に及ぼす影響に関する研究

Author

Kawamura, Maiko, Sasaki, Mina, SUZUKI, Suzu, Matsunaga, Kanna, Kishima, Haruka, and HIGUCHI, Masataka

Subjects
FOS: Psychology, 性犯罪, Social Psychology, Psychology, 感情開示, Social and Behavioral Sciences, 被害者非難
Abstract

人は被害者の存在を知ると、ネガティブな感情が喚起され、事件等の被害者が被害に遭ったことを自業自得だなどと非難することで、そのネガティブな感情を解消しようとすることがある。この被害者非難の減少を目的とした実験で、Harber, Podolski, & Williams(2015)は、喚起されたネガティブな感情を開示することでそれを解消し、被害者非難を減少させることができることを示した。具体的には、参加者を被害者のビデオクリップを見る群（被害者条件）と、非被害者のビデオクリップを見る群（非被害者条件）に分け、さらにその後感情を開示させる群（開示条件）と感情を抑圧させる群（抑圧条件）に分けて、計４条件で非難の程度に差が生じるかを検討した。その結果、被害者条件でのみ感情開示による非難の程度への影響が見られ、開示条件よりも抑圧条件の方が非難の程度が高かった。この研究は、被害者が非難されることによって受ける二次的被害を防ぐことができる可能性を示す有用な研究であり、その後も多く引用されている研究である。そのため、この結果の再現性が担保されるのかを確認することは、研究領域の発展のみならず、昨今問題視されている心理学全体の信頼性の確保にとっても非常に重要である。そこで本研究は、Harber et al.(2015)の研究１を追試し、「事件等の被害者に対する非難が感情を開示することによって減少する」という結果が再現されるかどうかを検討することを目的とする。なお、参加者への倫理的側面の配慮により、本研究ではビデオクリップではなく、同じ題材のシナリオを使用した。

Published
2022
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3. Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface

Author

Heo, Yunseok, primary, Ishimoto, Naito, additional, Jeon, Ye-Eun, additional, Yun, Ji-Hye, additional, Ohki, Mio, additional, Anraku, Yuki, additional, Sasaki, Mina, additional, Kita, Shunsuke, additional, Fukuhara, Hideo, additional, Ikuta, Tatsuya, additional, Kawakami, Kouki, additional, Inoue, Asuka, additional, Maenaka, Katsumi, additional, Tame, Jeremy R. H., additional, Lee, Weontae, additional, and Park, Sam-Yong, additional

Published
2022
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17. Endoscopic ultrasound-guided fine needle aspiration for Castleman’s disease originated in the retroperitoneum

Author

Fujii, Yuko, primary, Nishimura, Makoto, additional, Takemura, Takuya, additional, Kowazaki, Yuka, additional, Matsuoka, Junko, additional, Matsukawa, Miho, additional, Ushio, Yasuko, additional, Sasaki, Mina, additional, Uegaki, Satoko, additional, Yoshida, Takashi, additional, Matsuda, Yoko, additional, Arai, Tomio, additional, and Sugihara, Takahiko, additional

Published
2017
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19. Feasibility and safety of EUS-FNA for mediastinal lesions

Author

Fujii, Yuko, primary, Nishimura, Makoto, additional, Hosoya, Sayaka, additional, Kowazaki, Yuka, additional, Matsuoka, Junko, additional, Matsukawa, Miho, additional, Nakajima, Kenichiro, additional, Ushio, Yasuko, additional, Sasaki, Mina, additional, Matsuda, Yoko, additional, Arai, Tomio, additional, and Uegaki, Satoko, additional

Published
2016
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25. A case of lupus mesenteric vasculitis

Author

Mirokuji, Kie, primary, Nishimura, Makoto, additional, Omura, Takuya, additional, Tamura, Yuko, additional, Nakajima, Kenichirou, additional, Sasaki, Mina, additional, Uegaki, Satoko, additional, Komiya, Yoji, additional, Sugihara, Takahiko, additional, and Arai, Tomio, additional

Published
2014
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28. Characteristics of colonoscopic findings in the very elderly.

Author

Tanaka, Yasuo, Arai, Tomio, Uegaki, Satoko, Sasaki, Mina, Kanazawa, Nobuo, and Inamatsu, Takashi

Subjects
RECTUM tumors, COLON tumors, COLON diseases, AGE distribution, COLONOSCOPY, SEX distribution, DISEASE incidence, RETROSPECTIVE studies, OLD age, DIAGNOSIS, TUMOR risk factors, CANCER risk factors
Abstract

Aim To determine the incidence and endoscopic types of colorectal lesions diagnosed with colonoscopy in elderly patients. Methods Consecutive Japanese patients who underwent colonic endoscopy between 1994 and 2007 ( n = 5145; 2245 men and 2900 women, age 20-101 years) were examined retrospectively. Correlations between age, sex and number of lesions were analyzed. Results The incidence of advanced tumors was significantly correlated with increasing age in men ( P = 0.02), and tumors were detected mainly in the sigmoid colon and rectum in both sexes. Right-sided colon cancer was significantly more common in women compared with men ( P < 0.001). Polyps were detected throughout the colon, and their incidence was correlated significantly with increasing age in women ( P = 0.01). Diverticula were frequently detected in the ascending and sigmoid colon in both sexes. Left-sided diverticula were significantly more common in women compared with men ( P < 0.001). Lateral spreading tumors were detected mainly in the cecum in both sexes. Though the number of cases with angioectasia was small, angioectasia was slightly more common in the cecum and the ascending colon in women. Conclusions In the present study, the incidence of advanced tumors correlated with increasing age in men, and right-sided cases were significantly more common in women than in men. The incidence of polyps correlated with increasing age in women. Left-sided diverticula were significantly more common in women than in men. Geriatr Gerontol Int 2016; 16: 1319-1323. [ABSTRACT FROM AUTHOR]

Published
2016
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32. Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16(INK4a.)

Author

Sasaki, Mina, Kajiya, Hiroshi, Ozeki, Satoru, Okabe, Koji, and Ikebe, Tetsuro

Abstract

Reactive oxygen species (ROS) can cause severe damage to DNA, proteins and lipids in normal cells, contributing to carcinogenesis and various pathological conditions. While cellular senescence arrests the early phase of cell cycle without any detectable telomere loss or dysfunction. ROS is reported to contribute to induction of cellular senescence, as evidence by its premature onset upon treatment with antioxidants or inhibitors of cellular oxidant scavengers. Although cellular senescence is known to be implicated in tumor suppression, it remains unknown whether ROS initially contributed to be cellular senescence in normal human epidermal keratinocytes (NHEK) and their malignant counterparts. To clarify whether ROS induce cellular senescence in NHEKs, we examined the effect of hydrogen peroxide (H2O2) on the expression of cellular senescence-associated molecules in NHEKs, compared to in squamous carcinoma cells (SCCs). Hydrogen peroxide increased the number of cells positive in senescence associated-β-galactosidase (SA-β-Gal) activity in NHEKs, but not SCCs. The expression of cyclin-dependent kinase (CDK) inhibitors, especially p16(INK4a) was upregulated in NHEKs treated with H2O2. Interestingly, H2O2 suppressed the methylation of p16(INK4a), promoter region in NHEKs, but not in SCCs. Hydrogen peroxide also suppressed the expression of phosphorylated Rb and CDK4, resulting in arrest in G0/G1 phase in NHEKs, but not SCCs. Our results indicate that the ROS-induced cellular senescence in NHEKs was caused by the upregulation p16(INK4a) through demethylation in its promoter region, which is not detected in SCCs, suggesting that ROS-induced cellular senescence contributes to tumor suppression of NHEKs.

33. Cisplatin-induced programmed cell death ligand-2 expression is associated with metastasis ability in oral squamous cell carcinoma

Author

Sudo, Shunichi, Kajiya, Hiroshi, Okano, Shinji, Sasaki, Mina, Katsumata, Yuri, Ohno, Jun, Ikebe, Tetsuro, Hiraki, Akimitsu, and Okabe, Koji

Subjects
stomatognathic diseases
Abstract

Programmed cell death ligands (PD-Ls) are expressed in tumor cells where they bind to programmed cell death-1, an immunocyte co-receptor, resulting in tumor cell evasion from the immune system. Chemotherapeutic drugs have been recently reported to induce the expression of PD-L, such as PD-L1, in some cancer cells. However, little is known regarding PD-L2 expression and its role in oral squamous cell carcinoma (OSCC). In this study, we examined the effect of cisplatin on the expression and regulation of PD-L2 in OSCC cell lines and analyzed malignant behavior in PD-L2-expressing cells using colony, transwell and transformation assays. In addition, we examined PD-L2 expression in the tumor tissues of OSCC patients using cytology and tissue microarray methods. In OSCC cell lines, cisplatin treatment upregulated PD-L2 expression, along with that of the drug efflux transporter ABCG2, via signal transducers and activator of transcription (STAT) 1/3 activation. Moreover, PD-L2-positive or PD-L2-overexpressing cells demonstrated upregulation in both invasion and transformation ability but not in proliferation compared with PD-L2-negative or PD-L2-silencing cells. PD-L2 expression was also observed in OSCC cells of cytology samples and tissue from OSCC patients. The intensity of PD-L2 expression was correlated with more malignant morphological features in the histological appearance and an invasive pattern. Our findings indicate that cisplatin-upregulated PD-L2 expression in OSCC via STAT1/3 activation and the expression of PD-L2 are likely to be associated with malignancy in OSCC. The PD-L2 expression in cisplatin-resistant OSCC cells may be a critical factor in prognosis of advanced OSCC patients.

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