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540 results on '"Sasaki, Keisuke"'

19. Theoretical Study on the Open-Shell Electronic Structure and Electron Conductivity of [18]Annulene as a Molecular Parallel Circuit Model.

Author

Amamizu, Naoka, Nishida, Mitsuhiro, Sasaki, Keisuke, Kishi, Ryohei, and Kitagawa, Yasutaka

Subjects
PARALLEL electric circuits, ELECTRONIC structure, OHM'S law, GREEN'S functions, QUANTUM interference, QUANTUM groups
Abstract

Herein, the electron conductivities of [18]annulene and its derivatives are theoretically examined as a molecular parallel circuit model consisting of two linear polyenes. Their electron conductivities are estimated by elastic scattering Green's function (ESGF) theory and density functional theory (DFT) methods. The calculated conductivity of the [18]annulene does not follow the classical conductivity, i.e., Ohm's law, suggesting the importance of a quantum interference effect in single molecules. By introducing electron-withdrawing groups into the annulene framework, on the other hand, a spin-polarized electronic structure appears, and the quantum interference effect is significantly suppressed. In addition, the total current is affected by the spin polarization because of the asymmetry in the coupling constant between the molecule and electrodes. From these results, it is suggested that the electron conductivity as well as the quantum interference effect of π-conjugated molecular systems can be designed using their open-shell nature, which is chemically controlled by the substituents. [ABSTRACT FROM AUTHOR]

Published
2024
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22. UC-Secure Dynamic Searchable Symmetric Encryption Scheme

Author

Kurosawa, Kaoru, Sasaki, Keisuke, Ohta, Kiyohiko, Yoneyama, Kazuki, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Ogawa, Kazuto, editor, and Yoshioka, Katsunari, editor

Published
2016
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32. Oocyte-specific gene knockdown by intronic artificial microRNAs driven by Zp3 transcription in mice

Author

SASAKI, Keisuke, TAKAOKA, Saaya, and OBATA, Yayoi

Subjects
Gene Editing, Oocyte, Artificial microRNA, Zona pellucida glycoprotein 3, Zona Pellucida Glycoproteins, Transgenic, Introns, Mice, MicroRNAs, Gene Knockdown Techniques, Oocytes, Animals, Technology Report, Genome editing
Abstract

Conditional knockout technology is a powerful tool for investigating the spatiotemporal functions of target genes. However, generation of conditional knockout mice involves complicated breeding programs and considerable time. A recent study has shown that artificially designed microRNAs (amiRNAs), inserted into an intron of the constitutively expressed gene, induce knockdown of the targeted gene in mice, thus creating a simpler method to analyze the functions of target genes in oocytes. Here, to establish an oocyte-specific knockdown system, amiRNA sequences against enhanced green fluorescent protein (EGFP) were knocked into the intronic sites of the Zp3 gene. Knock-in mice were then bred with EGFP transgenic mice. Our results showed that Zp3-derived amiRNA successfully reduced EGFP fluorescence in the oocytes in a size-dependent manner. Importantly, knockdown of EGFP did not occur in somatic cells. Thus, we present our knockdown system as a tool for screening gene functions in mouse oocytes.

Published
2021

44. Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock

Author

Aoyama, Shinya, primary, Kim, Hyeon-Ki, additional, Hirooka, Rina, additional, Tanaka, Mizuho, additional, Shimoda, Takeru, additional, Chijiki, Hanako, additional, Kojima, Shuichi, additional, Sasaki, Keisuke, additional, Takahashi, Kengo, additional, Makino, Saneyuki, additional, Takizawa, Miku, additional, Takahashi, Masaki, additional, Tahara, Yu, additional, Shimba, Shigeki, additional, Shinohara, Kazuyuki, additional, and Shibata, Shigenobu, additional

Published
2021
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