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1. Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients

Author: Guasti L, Gaudio G, Lupi A, D'Avino M, Sala C, Mugellini A, Vulpis V, Felis S, Sarzani R, Vanasia M, Maffioli P, and Derosa G
Subjects: Ambulatory blood pressure, Canrenone, RAAS, ACE inhibitors, AT1R antagonist, Therapeutics. Pharmacology, RM1-950
Abstract: Luigina Guasti,1,* Giovanni Gaudio,2,* Alessandro Lupi,3 Marinella D’Avino,4 Carla Sala,5,6 Amedeo Mugellini,7 Vito Vulpis,8 Salvatore Felis,9 Riccardo Sarzani,10,11 Massimo Vanasia,12 Pamela Maffioli,7 Giuseppe Derosa7 1Research Center on Dyslipidemia, Internal Medicine 1, University of Insubria, Varese, Italy; 2Internal Medicine Division, Ospedale Angelo Bellini, ASST Valle Olona Somma, Varese, Italy; 3Cardiology Unit, ASL VCO Verbania-Domodossola, Verbania, Italy; 4Unit for the Treatment of Arterial Hypertension, Ospedale Cardarelli, Napoli, Italy; 5Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy; 6Cardiovascular Unit, Fondazione IRCCSS Policlinico, Milano, Italy; 7Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; 8Unit for the Diagnosis and Treatment of Arterial Hypertension, Department of Internal Medicine, Policlinico di Bari, Bari, Italy; 9Cardiology Unit, Ospedale Garibaldi, Catania, Italy; 10ESH Center of Hypertension, Internal Medicine and Geriatrics, University Politecnica delle Marche, Ancona, Italy; 11IRCCS-INRCA, Ancona, Italy; 12THERABEL GiEnne Pharma, Milano, Italy *These authors contributed equally to this work Background: Blockade of the renin–angiotensin–aldosterone system is a cornerstone in cardiovascular disease prevention and hypertension treatment. The relevance of ambulatory blood pressure monitoring (ABPM) has been widely confirmed for both increasing the accuracy of blood pressure (BP) measurements, particularly in pharmacological trials, and focusing on 24 h BP prognostic parameters. The aim of this study was to assess the effects of canrenone addition on ambulatory BP in uncontrolled hypertensive patients already treated with the highest tolerated dose of angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor (AT1R) antagonists plus hydrochlorothiazide (HCT). Methods: ABPM was performed at baseline and after 3 months of combination therapy in 158 outpatients with stage 1 or 2 hypertension who were randomized to add canrenone (50 or 100 mg) to the pre-existing therapy with ACE inhibitors or AT1R antagonists plus HCT. Twenty-four-hour systolic and diastolic BPs were considered normalized when the values were 10% with respect to diurnal values did not change during combination therapy. Conclusion: Canrenone addition to ACE inhibitors or AT1R antagonists plus HCT was associated with a significant reduction of 24 h BP and to an increased number of patients meeting 24 h ABPM targets in a clinical setting of uncontrolled stage 1 or 2 hypertension. Keywords: ambulatory blood pressure, canrenone, RAAS, ACE inhibitors, AT1R antagonist
Published: 2017

2. Management of patients with hypertension and chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. On behalf of the European Society of Hypertension Working Group on Hypertension and the Kidney

Author: Halimi, J, Sarafidis, P, Azizi, M, Bilo, G, Burkard, T, Bursztyn, M, Camafort, M, Chapman, N, Cottone, S, de Backer, T, Deinum, J, Delmotte, P, Dorobantu, M, Doumas, M, Dusing, R, Duly-Bouhanick, B, Fauvel, J, Fesler, P, Gaciong, Z, Gkaliagkousi, E, Gordin, D, Grassi, G, Grassos, C, Guerrot, D, Huart, J, Izzo, R, Jaén Águila, F, Járai, Z, Kahan, T, Kantola, I, Kociánová, E, Limbourg, F, Lopez-Sublet, M, Mallamaci, F, Manolis, A, Marketou, M, Mayer, G, Mazza, A, Macintyre, I, Mourad, J, Muiesan, M, Nasr, E, Nilsson, P, Oliveras, A, Ormezzano, O, Paixão-Dias, V, Papadakis, I, Papadopoulos, D, Perl, S, Polónia, J, Pontremoli, R, Pucci, G, Robles, N, Rubin, S, Ruilope, L, Rump, L, Saeed, S, Sanidas, E, Sarzani, R, Schmieder, R, Silhol, F, Sokolovic, S, Solbu, M, Soucek, M, Stergiou, G, Sudano, I, Tabbalat, R, Tengiz, I, Triantafyllidi, H, Tsioufis, K, Václavík, J, van der Giet, M, der Niepen, P, Veglio, F, Venzin, R, Viigimaa, M, Weber, T, Widimsky, J, Wuerzner, G, Zelveian, P, Zebekakis, P, Lueders, S, Persu, A, Kreutz, R, Vogt, L, Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Jaén Águila F, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg F, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre I, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, der Niepen PV, Veglio F, Venzin R, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, Vogt L., Halimi, J, Sarafidis, P, Azizi, M, Bilo, G, Burkard, T, Bursztyn, M, Camafort, M, Chapman, N, Cottone, S, de Backer, T, Deinum, J, Delmotte, P, Dorobantu, M, Doumas, M, Dusing, R, Duly-Bouhanick, B, Fauvel, J, Fesler, P, Gaciong, Z, Gkaliagkousi, E, Gordin, D, Grassi, G, Grassos, C, Guerrot, D, Huart, J, Izzo, R, Jaén Águila, F, Járai, Z, Kahan, T, Kantola, I, Kociánová, E, Limbourg, F, Lopez-Sublet, M, Mallamaci, F, Manolis, A, Marketou, M, Mayer, G, Mazza, A, Macintyre, I, Mourad, J, Muiesan, M, Nasr, E, Nilsson, P, Oliveras, A, Ormezzano, O, Paixão-Dias, V, Papadakis, I, Papadopoulos, D, Perl, S, Polónia, J, Pontremoli, R, Pucci, G, Robles, N, Rubin, S, Ruilope, L, Rump, L, Saeed, S, Sanidas, E, Sarzani, R, Schmieder, R, Silhol, F, Sokolovic, S, Solbu, M, Soucek, M, Stergiou, G, Sudano, I, Tabbalat, R, Tengiz, I, Triantafyllidi, H, Tsioufis, K, Václavík, J, van der Giet, M, der Niepen, P, Veglio, F, Venzin, R, Viigimaa, M, Weber, T, Widimsky, J, Wuerzner, G, Zelveian, P, Zebekakis, P, Lueders, S, Persu, A, Kreutz, R, Vogt, L, Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Jaén Águila F, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg F, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre I, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, der Niepen PV, Veglio F, Venzin R, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, and Vogt L.
Abstract: Objective Real-life management of patients with hypertension and chronic kidney disease (CKD) among European Society of Hypertension Excellence Centres (ESH-ECs) is unclear : we aimed to investigate it. Methods A survey was conducted in 2023. The questionnaire contained 64 questions asking ESH-ECs representatives to estimate how patients with CKD are managed. Results Overall, 88 ESH-ECS representatives from 27 countries participated. According to the responders, renin-angiotensin system (RAS) blockers, calcium-channel blockers and thiazides were often added when these medications were lacking in CKD patients, but physicians were more prone to initiate RAS blockers (90% [interquartile range: 70–95%]) than MRA (20% [10–30%]), SGLT2i (30% [20–50%]) or (GLP1-RA (10% [5–15%]). Despite treatment optimisation, 30% of responders indicated that hypertension remained uncontrolled (30% (15–40%) vs 18% [10%–25%]) in CKD and CKD patients, respectively). Hyperkalemia was the most frequent barrier to initiate RAS blockers, and dosage reduction was considered in 45% of responders when kalaemia was 5.5–5.9 mmol/L. Conclusions RAS blockers are initiated in most ESH-ECS in CKD patients, but MRA and SGLT2i initiations are less frequent. Hyperkalemia was the main barrier for initiation or adequate dosing of RAS blockade, and RAS blockers’ dosage reduction was the usual management.
Published: 2024

3. Prevalence, Clustering, and Current Management of Cardiovascular Risk Factors Upon First Referral to Hypertension Specialists: the APPROACH Study

Author: Del Pinto, R, Agabiti Rosei, C, Di Guardo, A, Giannattasio, C, Izzo, R, Mazza, A, Pucci, G, Sarzani, R, Tocci, G, Veglio, F, Volpe, M, Grassi, G, Muiesan, M, Ferri, C, Del Pinto R, Agabiti Rosei C, Di Guardo A, Giannattasio C, Izzo R, Mazza A, Pucci G, Sarzani R, Tocci G, Veglio F, Volpe M, Grassi G, Muiesan ML, Ferri C, Del Pinto, R, Agabiti Rosei, C, Di Guardo, A, Giannattasio, C, Izzo, R, Mazza, A, Pucci, G, Sarzani, R, Tocci, G, Veglio, F, Volpe, M, Grassi, G, Muiesan, M, Ferri, C, Del Pinto R, Agabiti Rosei C, Di Guardo A, Giannattasio C, Izzo R, Mazza A, Pucci G, Sarzani R, Tocci G, Veglio F, Volpe M, Grassi G, Muiesan ML, and Ferri C
Abstract: Introduction: Several observational studies have been conducted to assess the prevalence of cardiovascular risk factors in hypertensive patients; however, none has yet investigated prevalence, clustering, and current management of cardiovascular risk factors upon first referral to hypertension specialists, which is the aim of the present study. Methods: Consecutive adult outpatients with essential/secondary hypertension were included at the time of their first referral to hypertension specialists at 13 Italian centers in the period April 2022-2023 if they had at least one additional major cardiovascular risk factor among LDL-hypercholesterolemia, type 2 diabetes, and cigarette smoking. Prevalence, degree of control, and current management strategies of cardiovascular risk factors were assessed. Results: A total of 255 individuals were included, 40.2% women and 98.4% Caucasian. Mean age was 60.3±13.3 years and mean blood pressure [BP] was 140.3±17.9/84.8±12.3 mmHg). Most participants were smokers (55.3%), had a sedentary lifestyle (75.7%), suffered from overweight/obesity (51%) or high LDL-cholesterol (41.6%), had never adopted strategies to lose weight (55.7%), and were not on a low-salt diet (57.4%). Only a minority of patients reported receiving specialist counseling, and 27.9% had never received recommendations to correct unhealthy lifestyle habits. Nearly 90% of individuals with an estimated high/very high cardiovascular risk profile did not achieve recommended LDL-cholesterol targets. Conclusions: In patients with hypertension, both pharmacological and lifestyle therapeutic advice are yet to improve before referral to hypertension specialists. This should be considered in the primary care setting in order to optimize cardiovascular risk management strategies.
Published: 2024

4. May Measure Month 2022 in Italy: A Focus on Fixed-dose Combination, Therapeutic Adherence, and Medical Inertia in a Nationwide Survey

Author: Del Pinto, R, Agabiti Rosei, C, Borghi, C, Cipollini, F, Cottone, S, De Giorgi, G, Di Guardo, A, Dugnani, M, Fabris, B, Giannattasio, C, Giacchetti, G, Minuz, P, Mulè, G, Nazzaro, P, Parati, G, Rattazzi, M, Saladini, F, Salvetti, M, Sarzani, R, Savoia, C, Tocci, G, Veglio, F, Volpe, M, Vulpis, V, Baldini, G, Ferri, C, Muiesan, M, Del Pinto R., Agabiti Rosei C., Borghi C., Cipollini F., Cottone S., De Giorgi G. A., Di Guardo A., Dugnani M., Fabris B., Giannattasio C., Giacchetti G., Minuz P., Mulè G., Nazzaro P., Parati G., Rattazzi M., Saladini F., Salvetti M., Sarzani R., Savoia C., Tocci G., Veglio F., Volpe M., Vulpis V., Baldini G., Ferri C., Muiesan M. L., Del Pinto, R, Agabiti Rosei, C, Borghi, C, Cipollini, F, Cottone, S, De Giorgi, G, Di Guardo, A, Dugnani, M, Fabris, B, Giannattasio, C, Giacchetti, G, Minuz, P, Mulè, G, Nazzaro, P, Parati, G, Rattazzi, M, Saladini, F, Salvetti, M, Sarzani, R, Savoia, C, Tocci, G, Veglio, F, Volpe, M, Vulpis, V, Baldini, G, Ferri, C, Muiesan, M, Del Pinto R., Agabiti Rosei C., Borghi C., Cipollini F., Cottone S., De Giorgi G. A., Di Guardo A., Dugnani M., Fabris B., Giannattasio C., Giacchetti G., Minuz P., Mulè G., Nazzaro P., Parati G., Rattazzi M., Saladini F., Salvetti M., Sarzani R., Savoia C., Tocci G., Veglio F., Volpe M., Vulpis V., Baldini G., Ferri C., and Muiesan M. L.
Abstract: Introduction: Hypertension is the main risk factor for cardiovascular diseases (CVD). Notably, only about half of hypertensive patients manage to achieve the recommended blood pressure (BP) control. Main reasons for the persistence of uncontrolled BP during treatment are lack of compliance on the patients' side, and therapeutic inertia on physicians' side. Methods: During the global BP screening campaign "May Measure Month" (MMM) (May 1st to July 31st, 2022), a nationwide, cross-sectional, opportunistic study endorsed by the Italian Society of Hypertension was conducted on volunteer adults ≥ 18 years to raise awareness of the health issues surrounding high BP. A questionnaire on demographic/clinical features and questions on the use of fixed-dose single-pills for the treatment of hypertension was administered. BP was measured with standard procedures. Results: A total of 1612 participants (mean age 60.0±15.41 years; 44.7% women) were enrolled. Their mean BP was 128.5±18.1/77.1±10.4 mmHg. About half of participants were sedentary, or overweight/obese, or hypertensive. 55.5% individuals with complete BP assessment had uncontrolled hypertension. Most were not on a fixed-dose combination of antihypertensive drugs and did not regularly measure BP at home. Self-reported adherence to BP medications was similar between individuals with controlled and uncontrolled BP (95% vs 95.5%). Conclusions: This survey identified a remarkable degree of therapeutic inertia and poor patients' involvement in the therapeutic process and its monitoring in the examined population, underlining the importance of prevention campaigns to identify areas of unsatisfactory management of hypertension, to increase risk factors' awareness in the population with the final purpose of reducing cardiovascular risk.
Published: 2024

5. Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire

Author: Halimi, J, Sarafidis, P, Azizi, M, Bilo, G, Burkard, T, Bursztyn, M, Camafort, M, Chapman, N, Cottone, S, de Backer, T, Deinum, J, Delmotte, P, Dorobantu, M, Doumas, M, Dusing, R, Duly-Bouhanick, B, Fauvel, J, Fesler, P, Gaciong, Z, Gkaliagkousi, E, Gordin, D, Grassi, G, Grassos, C, Guerrot, D, Huart, J, Izzo, R, Águila, F, Járai, Z, Kahan, T, Kantola, I, Kociánová, E, Limbourg, F, Lopez-Sublet, M, Mallamaci, F, Manolis, A, Marketou, M, Mayer, G, Mazza, A, Macintyre, I, Mourad, J, Muiesan, M, Nasr, E, Nilsson, P, Oliveras, A, Ormezzano, O, Paixão-Dias, V, Papadakis, I, Papadopoulos, D, Perl, S, Polónia, J, Pontremoli, R, Pucci, G, Robles, N, Rubin, S, Ruilope, L, Rump, L, Saeed, S, Sanidas, E, Sarzani, R, Schmieder, R, Silhol, F, Sokolovic, S, Solbu, M, Soucek, M, Stergiou, G, Sudano, I, Tabbalat, R, Tengiz, I, Triantafyllidi, H, Tsioufis, K, Václavík, J, van der Giet, M, Van der Niepen, P, Veglio, F, Venzin, R, Viigimaa, M, Weber, T, Widimsky, J, Wuerzner, G, Zelveian, P, Zebekakis, P, Lueders, S, Persu, A, Kreutz, R, Vogt, L, Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Águila FJ, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg FP, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre IM, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, Van der Niepen P, Veglio F, Venzin RM, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, Vogt L, Halimi, J, Sarafidis, P, Azizi, M, Bilo, G, Burkard, T, Bursztyn, M, Camafort, M, Chapman, N, Cottone, S, de Backer, T, Deinum, J, Delmotte, P, Dorobantu, M, Doumas, M, Dusing, R, Duly-Bouhanick, B, Fauvel, J, Fesler, P, Gaciong, Z, Gkaliagkousi, E, Gordin, D, Grassi, G, Grassos, C, Guerrot, D, Huart, J, Izzo, R, Águila, F, Járai, Z, Kahan, T, Kantola, I, Kociánová, E, Limbourg, F, Lopez-Sublet, M, Mallamaci, F, Manolis, A, Marketou, M, Mayer, G, Mazza, A, Macintyre, I, Mourad, J, Muiesan, M, Nasr, E, Nilsson, P, Oliveras, A, Ormezzano, O, Paixão-Dias, V, Papadakis, I, Papadopoulos, D, Perl, S, Polónia, J, Pontremoli, R, Pucci, G, Robles, N, Rubin, S, Ruilope, L, Rump, L, Saeed, S, Sanidas, E, Sarzani, R, Schmieder, R, Silhol, F, Sokolovic, S, Solbu, M, Soucek, M, Stergiou, G, Sudano, I, Tabbalat, R, Tengiz, I, Triantafyllidi, H, Tsioufis, K, Václavík, J, van der Giet, M, Van der Niepen, P, Veglio, F, Venzin, R, Viigimaa, M, Weber, T, Widimsky, J, Wuerzner, G, Zelveian, P, Zebekakis, P, Lueders, S, Persu, A, Kreutz, R, Vogt, L, Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Águila FJ, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg FP, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre IM, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, Van der Niepen P, Veglio F, Venzin RM, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, and Vogt L
Abstract: Objective: Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear. Methods: A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (ESH-ECs) at first referral visit. The questionnaire contained 64 questions with which ESH-ECs representatives were asked to estimate preexisting CKD management quality. Results: Overall, 88 ESH-ECs from 27 countries participated (fully completed surveys: 66/88 [75.0%]). ESH-ECs reported that 28% (median, interquartile range: 15-50%) had preexisting CKD, with 10% of them (5-30%) previously referred to a nephrologist, while 30% (15-40%) had resistant hypertension. The reported rate of previous recent (<6 months) estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) testing were 80% (50-95%) and 30% (15-50%), respectively. The reported use of renin-angiotensin system blockers was 80% (70-90%). When a nephrologist was part of the ESH-EC teams the reported rates SGLT2 inhibitors (27.5% [20-40%] vs. 15% [10-25], P = 0.003), GLP1-RA (10% [10-20%] vs. 5% [5-10%], P = 0.003) and mineralocorticoid receptor antagonists (20% [10-30%] vs. 15% [10-20%], P = 0.05) use were greater as compared to ESH-ECs without nephrologist participation. The rate of reported resistant hypertension, recent eGFR and UACR results and management of CKD patients prior to referral varied widely across countries. Conclusions: Our estimation indicates deficits regarding CKD screening, use of nephroprotective drugs and referral to nephrologists before referral to ESH-ECs but results varied widely across countries. This information can be used to build specific programs to improve care in hypertensives with CKD.
Published: 2024

6. The impact of the COVID-19 Pandemic on hypertension phenotypes (ESH ABPM COVID-19 study)

Author: Ostrowska, A, Wojciechowska, W, Rajzer, M, Weber, T, Bursztyn, M, Persu, A, Stergiou, G, Kiełbasa, G, Chrostowska, M, Doumas, M, Parati, G, Bilo, G, Grassi, G, Mancia, G, Januszewicz, A, Kreutz, R, Narkiewicz, K, Dubiela, A, Imprialos, K, Stavropoulos, K, de Freminville, J, Azizi, M, Cunha, P, Lewandowski, J, Strzelczyk, J, Wuerzner, G, Gosk-Przybyłek, M, Szwęch, E, Prejbisz, A, Van der Niepen, P, Kahan, T, Jekell, A, Spaak, J, Tsioufis, K, Ehret, G, Doroszko, A, Kubalski, P, Polonia, J, Styczkiewicz, K, Styczkiewicz, M, Mazur, S, Veglio, F, Rabbia, F, Eula, E, Águila, F, Sarzani, R, Spannella, F, Jarai, Z, Papadopoulos, D, Sublet, M, Grassos, C, Kahrimanidis, I, Gkaliagkousi, E, Triantafyllou, A, Grodzicki, T, Wizner, B, Seweryn, A, Moczulska, B, Ntineri, A, Robles, N, Widmiski, J, Zbroch, E, Ostrowska, Aleksandra, Wojciechowska, Wiktoria, Rajzer, Marek, Weber, Thomas, Bursztyn, Michael, Persu, Alexandre, Stergiou, George, Kiełbasa, Grzegorz, Chrostowska, Marzena, Doumas, Michaelis, Parati, Gianfranco, Bilo, Grzegorz, Grassi, Guido, Mancia, Giuseppe, Januszewicz, Andrzej, Kreutz, Reinhold, Narkiewicz, Krzysztof, Dubiela, Andżelina, Imprialos, Konstantinos, Stavropoulos, Konstantinos, de Freminville, Jean-Baptiste, Azizi, Michel, Cunha, Pedro Guimarães, Lewandowski, Jacek, Strzelczyk, Jakub, Wuerzner, Gregoire, Gosk-Przybyłek, Maria, Szwęch, Elżbieta, Prejbisz, Aleksander, Van der Niepen, Patricia, Kahan, Thomas, Jekell, Andreas, Spaak, Jonas, Tsioufis, Konstantinos, Ehret, Georg, Doroszko, Adrian, Kubalski, Piotr, Polonia, Jorge, Styczkiewicz, Katarzyna, Styczkiewicz, Marek, Mazur, Stanisław, Veglio, Franco, Rabbia, Franco, Eula, Elisabetta, Águila, Fernando Jaen, Sarzani, Riccardo, Spannella, Francesco, Jarai, Zoltan, Papadopoulos, Dimitrios, Sublet, Marilucy Lopez –, Grassos, Charalampos, Kahrimanidis, Ioannis, Gkaliagkousi, Eugenia, Triantafyllou, Areti, Grodzicki, Tomasz, Wizner, Barbara, Seweryn, Aleksandra, Moczulska, Beata, Ntineri, Angeliki, Robles, Nicolas Roberto, Widmiski, Jiri, Zbroch, Edyta, Ostrowska, A, Wojciechowska, W, Rajzer, M, Weber, T, Bursztyn, M, Persu, A, Stergiou, G, Kiełbasa, G, Chrostowska, M, Doumas, M, Parati, G, Bilo, G, Grassi, G, Mancia, G, Januszewicz, A, Kreutz, R, Narkiewicz, K, Dubiela, A, Imprialos, K, Stavropoulos, K, de Freminville, J, Azizi, M, Cunha, P, Lewandowski, J, Strzelczyk, J, Wuerzner, G, Gosk-Przybyłek, M, Szwęch, E, Prejbisz, A, Van der Niepen, P, Kahan, T, Jekell, A, Spaak, J, Tsioufis, K, Ehret, G, Doroszko, A, Kubalski, P, Polonia, J, Styczkiewicz, K, Styczkiewicz, M, Mazur, S, Veglio, F, Rabbia, F, Eula, E, Águila, F, Sarzani, R, Spannella, F, Jarai, Z, Papadopoulos, D, Sublet, M, Grassos, C, Kahrimanidis, I, Gkaliagkousi, E, Triantafyllou, A, Grodzicki, T, Wizner, B, Seweryn, A, Moczulska, B, Ntineri, A, Robles, N, Widmiski, J, Zbroch, E, Ostrowska, Aleksandra, Wojciechowska, Wiktoria, Rajzer, Marek, Weber, Thomas, Bursztyn, Michael, Persu, Alexandre, Stergiou, George, Kiełbasa, Grzegorz, Chrostowska, Marzena, Doumas, Michaelis, Parati, Gianfranco, Bilo, Grzegorz, Grassi, Guido, Mancia, Giuseppe, Januszewicz, Andrzej, Kreutz, Reinhold, Narkiewicz, Krzysztof, Dubiela, Andżelina, Imprialos, Konstantinos, Stavropoulos, Konstantinos, de Freminville, Jean-Baptiste, Azizi, Michel, Cunha, Pedro Guimarães, Lewandowski, Jacek, Strzelczyk, Jakub, Wuerzner, Gregoire, Gosk-Przybyłek, Maria, Szwęch, Elżbieta, Prejbisz, Aleksander, Van der Niepen, Patricia, Kahan, Thomas, Jekell, Andreas, Spaak, Jonas, Tsioufis, Konstantinos, Ehret, Georg, Doroszko, Adrian, Kubalski, Piotr, Polonia, Jorge, Styczkiewicz, Katarzyna, Styczkiewicz, Marek, Mazur, Stanisław, Veglio, Franco, Rabbia, Franco, Eula, Elisabetta, Águila, Fernando Jaen, Sarzani, Riccardo, Spannella, Francesco, Jarai, Zoltan, Papadopoulos, Dimitrios, Sublet, Marilucy Lopez –, Grassos, Charalampos, Kahrimanidis, Ioannis, Gkaliagkousi, Eugenia, Triantafyllou, Areti, Grodzicki, Tomasz, Wizner, Barbara, Seweryn, Aleksandra, Moczulska, Beata, Ntineri, Angeliki, Robles, Nicolas Roberto, Widmiski, Jiri, and Zbroch, Edyta
Published: 2024

7. Plasma levels of proprotein convertase subtilisin/kexintype 9 are inversely associated with N-terminal pro B-type natriuretic peptide in older population

Author: Spannella, F., primary, Giulietti, F., additional, Galeazzi, R., additional, Passarelli, A., additional, Re, S., additional, Di Pentima, C., additional, Allevi, M., additional, Magni, P., additional, and Sarzani, R., additional
Published: 2023
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8. Positivity of statin-associated muscle symptoms – Clinical index in a hypertensive population candidated to lipid-lowering therapy but not taking statins

Author: Sarzani, R., primary, Giulietti, F., additional, Allevi, M., additional, Sarnari, S., additional, Di Pentima, C., additional, Poliseno, C., additional, and Spannella, F., additional
Published: 2023
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9. The Role of Registers in Increasing Knowledge and Improving Management of Children and Adolescents Affected by Familial Hypercholesterolemia: the LIPIGEN Pediatric Group

Author: Gazzotti, M, Casula, M, Bertolini, S, Capra, M, Olmastroni, E, Catapano, A, Pederiva, C, Allevi, M, Arca, M, Auricchio, R, Averna, M, Baldera, D, Banderali, G, Bartuli, A, Biasucci, G, Borghi, C, Bruzzi, P, Buganza, R, Buonuomo, P, Calabro, P, Calandra, S, Carubbi, F, Cesaro, A, Cipollone, F, Citroni, N, Covetti, G, Cremonini, A, D'Addato, S, Ben, M, Di Taranto, M, Fortunato, G, Franceschi, R, Galimberti, F, Genovesi, S, Giammanco, A, Grigore, L, Guardamagna, O, Iannuzzi, A, Iannuzzo, G, Lascala, L, Locatelli, F, Iughetti, L, Madaghiele, S, Mandraffino, G, Mannarino, M, Marco, B, Maroni, L, Minicocci, I, Mombelli, G, Muntoni, S, Nascimbeni, F, Parati, G, Passaro, A, Pavanello, C, Pellegatta, F, Perla, F, Generale, M, Pirro, M, Pisciotta, L, Pujia, A, Purrello, F, Rinaldi, E, Sarzani, R, Scicali, R, Suppressa, P, Tarugi, P, Verachtert, S, Vigna, G, Werba, J, Zambon, A, Zambon, S, Zenti, M, Gazzotti M., Casula M., Bertolini S., Capra M. E., Olmastroni E., Catapano A. L., Pederiva C., Allevi M., Arca M., Auricchio R., Averna M., Baldera D., Banderali G., Bartuli A., Biasucci G., Borghi C., Bruzzi P., Buganza R., Buonuomo P. S., Calabro P., Calandra S., Carubbi F., Cesaro A., Cipollone F., Citroni N., Covetti G., Cremonini A., D'Addato S., Ben M. D., Di Taranto M. D., Fortunato G., Franceschi R., Galimberti F., Genovesi S., Giammanco A., Grigore L., Guardamagna O., Iannuzzi A., Iannuzzo G., Lascala L., Locatelli F., Iughetti L., Madaghiele S., Mandraffino G., Mannarino M. R., Marco B., Maroni L., Minicocci I., Mombelli G., Muntoni S., Nascimbeni F., Parati G., Passaro A., Pavanello C., Pellegatta F., Perla F. M., Generale M., Pirro M., Pisciotta L., Pujia A., Purrello F., Rinaldi E., Sarzani R., Scicali R., Suppressa P., Tarugi P., Verachtert S., Vigna G. B., Werba J. P., Zambon A., Zambon S., Zenti M. G., Gazzotti, M, Casula, M, Bertolini, S, Capra, M, Olmastroni, E, Catapano, A, Pederiva, C, Allevi, M, Arca, M, Auricchio, R, Averna, M, Baldera, D, Banderali, G, Bartuli, A, Biasucci, G, Borghi, C, Bruzzi, P, Buganza, R, Buonuomo, P, Calabro, P, Calandra, S, Carubbi, F, Cesaro, A, Cipollone, F, Citroni, N, Covetti, G, Cremonini, A, D'Addato, S, Ben, M, Di Taranto, M, Fortunato, G, Franceschi, R, Galimberti, F, Genovesi, S, Giammanco, A, Grigore, L, Guardamagna, O, Iannuzzi, A, Iannuzzo, G, Lascala, L, Locatelli, F, Iughetti, L, Madaghiele, S, Mandraffino, G, Mannarino, M, Marco, B, Maroni, L, Minicocci, I, Mombelli, G, Muntoni, S, Nascimbeni, F, Parati, G, Passaro, A, Pavanello, C, Pellegatta, F, Perla, F, Generale, M, Pirro, M, Pisciotta, L, Pujia, A, Purrello, F, Rinaldi, E, Sarzani, R, Scicali, R, Suppressa, P, Tarugi, P, Verachtert, S, Vigna, G, Werba, J, Zambon, A, Zambon, S, Zenti, M, Gazzotti M., Casula M., Bertolini S., Capra M. E., Olmastroni E., Catapano A. L., Pederiva C., Allevi M., Arca M., Auricchio R., Averna M., Baldera D., Banderali G., Bartuli A., Biasucci G., Borghi C., Bruzzi P., Buganza R., Buonuomo P. S., Calabro P., Calandra S., Carubbi F., Cesaro A., Cipollone F., Citroni N., Covetti G., Cremonini A., D'Addato S., Ben M. D., Di Taranto M. D., Fortunato G., Franceschi R., Galimberti F., Genovesi S., Giammanco A., Grigore L., Guardamagna O., Iannuzzi A., Iannuzzo G., Lascala L., Locatelli F., Iughetti L., Madaghiele S., Mandraffino G., Mannarino M. R., Marco B., Maroni L., Minicocci I., Mombelli G., Muntoni S., Nascimbeni F., Parati G., Passaro A., Pavanello C., Pellegatta F., Perla F. M., Generale M., Pirro M., Pisciotta L., Pujia A., Purrello F., Rinaldi E., Sarzani R., Scicali R., Suppressa P., Tarugi P., Verachtert S., Vigna G. B., Werba J. P., Zambon A., Zambon S., and Zenti M. G.
Abstract: Pathology registers can be a useful tool to overcome obstacles in the identification and management of familial hypercholesterolemia since childhood. In 2018, the LIPIGEN pediatric group was constituted within the Italian LIPIGEN study to focus on FH subjects under 18 years. This work aimed at discussing its recent progress and early outcomes. Demographic, biochemical, and genetic baseline characteristics were collected, with an in-depth analysis of the genetic defects. The analysis was carried out on 1,602 children and adolescents (mean age at baseline 9.9 ± 4.0 years), and almost the whole cohort underwent the genetic test (93.3%). Overall, the untreated mean value of LDL-C was 220.0 ± 97.2 mg/dl, with an increasing gradient from subjects with a negative (N = 317; mean untreated LDL-C = 159.9 ± 47.7 mg/dl), inconclusive (N = 125; mean untreated LDL-C = 166.4 ± 56.5 mg/dl), or positive (N = 1,053; mean untreated LDL-C = 246.5 ± 102.1 mg/dl) genetic diagnosis of FH. In the latter group, the LDL-C values presented a great variability based on the number and the biological impact of involved causative variants. The LIPIGEN pediatric group represents one of the largest cohorts of children with FH, allowing the deepening of the characterization of their baseline and genetic features, providing the basis for further longitudinal investigations for complete details.
Published: 2022

10. Erratum: Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension (PLoS ONE (2020) 15:10 (e0237297) DOI: 10.1371/journal.pone.0237297)

Author: Iaccarino G., Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Iaccarino G., Grassi G., Borghi C., Carugo S., Fallo F., Ferri C., Giannattasio C., Grassi D., Letizia C., Mancusi C., Minuz P., Perlini S., Pucci G., Rizzoni D., Salvetti M., Sarzani R., Sechi L., Veglio F., Volpe M., Iaccarino G., Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Iaccarino G., Grassi G., Borghi C., Carugo S., Fallo F., Ferri C., Giannattasio C., Grassi D., Letizia C., Mancusi C., Minuz P., Perlini S., Pucci G., Rizzoni D., Salvetti M., Sarzani R., Sechi L., Veglio F., and Volpe M.
Abstract: There is an error in the third sentence of the second paragraph of the Introduction section of this article [1]. Prior to the publication of this article [1], reference 6 was retracted by The New England Journal of Medicine and should not have been cited [2]. The correct reference is: WHO. Gender and COVID-19: Advocacy brief [Internet]. 2020 [cited 2021 Jun 10]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Advocacy_brief-Gender2020.1 As a result of this correction to the references, the following text in the second paragraph of the discussion is removed: “[odds ratio 0.79 (CI 0.65–0.95)] in an extensive observational database collecting patients from Asia, Europe, and the United States.” The authors provide the following additional clarifications: As stated in the article’s Discussion, the study design does not allow conclusions to be drawn about causal relationships. As such, the authors provide revised wording for the first sentence of the Conclusions section of the Abstract, and the first sentence of the Conclusions section of the Discussion. The correct sentences are, respectively, “Our study demonstrates that gender may be the primary determinant of the disease’s severity among COVID-19” and “Our study demonstrates a possible gender effect for women in COVID-19 that are protected from more severe clinical presentations of the disease.” In the study registry [3], the registered timeframe for the secondary outcome “Number and type of anthropometric and clinical parameters that associate with COVID19 and COVID-19 severity” was 3 months. The article reports a shorter observation period between March 9th and April 29th 2020. The authors wish to clarify that the study design included a steering committee that performed an interim analysis. The number of required patients was collected more quickly than expected.
Published: 2022

11. Clinical Approach in the Management of Paediatric Patients with Familial Hypercholesterolemia: A National Survey Conducted by the LIPIGEN Paediatric Group

Author: Pederiva, C, Gazzotti, M, Arca, M, Averna, M, Banderali, G, Biasucci, G, Brambilla, M, Buonuomo, P, Calabrò, P, Cipollone, F, Citroni, N, D'Addato, S, Del Ben, M, Genovesi, S, Guardamagna, O, Iannuzzo, G, Iughetti, L, Mandraffino, G, Maroni, L, Mombelli, G, Muntoni, S, Nascimbeni, F, Passaro, A, Pellegatta, F, Pirro, M, Pisciotta, L, Pujia, R, Sarzani, R, Scicali, R, Suppressa, P, Zambon, S, Zenti, M, Calandra, S, Catapano, A, Tarugi, P, Galimberti, F, Casula, M, Capra, M, Pederiva, Cristina, Gazzotti, Marta, Arca, Marcello, Averna, Maurizio, Banderali, Giuseppe, Biasucci, Giacomo, Brambilla, Marta, Buonuomo, Paola Sabrina, Calabrò, Paolo, Cipollone, Francesco, Citroni, Nadia, D'Addato, Sergio, Del Ben, Maria, Genovesi, Simonetta, Guardamagna, Ornella, Iannuzzo, Gabriella, Iughetti, Lorenzo, Mandraffino, Giuseppe, Maroni, Lorenzo, Mombelli, Giuliana, Muntoni, Sandro, Nascimbeni, Fabio, Passaro, Angelina, Pellegatta, Fabio, Pirro, Matteo, Pisciotta, Livia, Pujia, Roberta, Sarzani, Riccardo, Scicali, Roberto, Suppressa, Patrizia, Zambon, Sabina, Zenti, Maria Grazia, Calandra, Sebastiano, Catapano, Alberico Luigi, Tarugi, Patrizia, Galimberti, Federica, Casula, Manuela, Capra, Maria Elena, Pederiva, C, Gazzotti, M, Arca, M, Averna, M, Banderali, G, Biasucci, G, Brambilla, M, Buonuomo, P, Calabrò, P, Cipollone, F, Citroni, N, D'Addato, S, Del Ben, M, Genovesi, S, Guardamagna, O, Iannuzzo, G, Iughetti, L, Mandraffino, G, Maroni, L, Mombelli, G, Muntoni, S, Nascimbeni, F, Passaro, A, Pellegatta, F, Pirro, M, Pisciotta, L, Pujia, R, Sarzani, R, Scicali, R, Suppressa, P, Zambon, S, Zenti, M, Calandra, S, Catapano, A, Tarugi, P, Galimberti, F, Casula, M, Capra, M, Pederiva, Cristina, Gazzotti, Marta, Arca, Marcello, Averna, Maurizio, Banderali, Giuseppe, Biasucci, Giacomo, Brambilla, Marta, Buonuomo, Paola Sabrina, Calabrò, Paolo, Cipollone, Francesco, Citroni, Nadia, D'Addato, Sergio, Del Ben, Maria, Genovesi, Simonetta, Guardamagna, Ornella, Iannuzzo, Gabriella, Iughetti, Lorenzo, Mandraffino, Giuseppe, Maroni, Lorenzo, Mombelli, Giuliana, Muntoni, Sandro, Nascimbeni, Fabio, Passaro, Angelina, Pellegatta, Fabio, Pirro, Matteo, Pisciotta, Livia, Pujia, Roberta, Sarzani, Riccardo, Scicali, Roberto, Suppressa, Patrizia, Zambon, Sabina, Zenti, Maria Grazia, Calandra, Sebastiano, Catapano, Alberico Luigi, Tarugi, Patrizia, Galimberti, Federica, Casula, Manuela, and Capra, Maria Elena
Abstract: Detection and treatment of patients with familial hypercholesterolemia (FH) starting from childhood is fundamental to reduce morbidity and mortality. The activity of National realities such as the LIPIGEN (LIpid transPort disorders Italian GEnetic Network) Paediatric Group, founded in 2018, is a milestone in this context. The aim of this exploratory survey, conducted in October 2021 among Italian lipid clinics included in the LIPIGEN Paediatric Group, was to investigate the current clinical approach in the management and treatment of paediatric patients with suspected FH. A digital questionnaire composed of 20 questions investigating nutritional treatment and nutraceutical and pharmacological therapy for children and adolescents with FH was proposed to the principal investigators of 30 LIPIGEN centres. Twenty-four centres responded to the section referring to children aged < 10 years and 30 to that referring to adolescents. Overall, 66.7% of children and 73.3% of adolescents were given lipid-lowering nutritional treatment as the first intervention level for at least 3–4 months (29.2% and 23.3%) or 6–12 months (58.3% and 53.3%). Nutraceuticals were considered in 41.7% (regarding children) and 50.0% (regarding adolescents) of the centres as a supplementary approach to diet. Lipid-lowering drug therapy initiation was mainly recommended (91.7% and 80.0%). In 83.3% of children and 96.7% of adolescents, statins were the most frequently prescribed drug. We highlighted several differences in the treatment of paediatric patients with suspected FH among Italian centres; however, the overall approach is in line with the European Atherosclerosis Society (EAS) recommendations for FH children and adolescents. We consider this survey as a starting point to reinforce collaboration between LIPIGEN centres and to elaborate in the near future a consensus document on the management of paediatric patients with suspected FH so as to improve and uniform detection, management, and treat
Published: 2023

12. Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real‐life setting: the PROSISA Study

Author: Casula, M., Gazzotti, M., Bonaiti, F., Oimastroni, E., Arca, M., Averna, M., Zambon, A., Catapano, A. L., Montali, A., Giammanco, A., Biolo, G., Vinci, P., Borghi, C., D'Addato, S., Bossi, A. C., Meregalli, G., Branchi, A., Squiccimarro, G., Cavalot, F., Ramadori, L., Cipollone, F., Bucci, M., Del Ben, M., Angelico, F., Fiorenza, A. M., Colombo, E., Grigore, L., Zampoleri, V., Lupattelli, G., Gandolfo, V., Mandraffino, G., Savarino, F., Mombelli, G., Pavanello, C., Pisciotta, L., Pasta, A., Purrello, F., Scicali, R., Rubba, P., Fortunato, G., Sabba, C., Suppressa, P., Sarzani, R., Di Pentima, C., Vigna, G. B., Colangiulo, A., Werba, J. P., Vigo, L. M., Zambon, S., Previato, L., Zenti, M. G., Maneschi, C., Casula, M., Gazzotti, M., Bonaiti, F., Oimastroni, E., Arca, M., Averna, M., Zambon, A., Catapano, A. L., Montali, A., Giammanco, A., Biolo, G., Vinci, P., Borghi, C., D'Addato, S., Bossi, A. C., Meregalli, G., Branchi, A., Squiccimarro, G., Cavalot, F., Ramadori, L., Cipollone, F., Bucci, M., Del Ben, M., Angelico, F., Fiorenza, A. M., Colombo, E., Grigore, L., Zampoleri, V., Lupattelli, G., Gandolfo, V., Mandraffino, G., Savarino, F., Mombelli, G., Pavanello, C., Pisciotta, L., Pasta, A., Purrello, F., Scicali, R., Rubba, P., Fortunato, G., Sabba, C., Suppressa, P., Sarzani, R., Di Pentima, C., Vigna, G. B., Colangiulo, A., Werba, J. P., Vigo, L. M., Zambon, S., Previato, L., Zenti, M. G., Maneschi, C., Casula M, Gazzotti M, Bonaiti F, OImastroni E, Arca M, Averna M, Zambon A, Catapano AL, PROSISA Study Group, Borghi C, Casula M., Gazzotti M., Bonaiti F., OImastroni E., Arca M., Averna M., Zambon A., Catapano A.L., Montali A., Giammanco A., Biolo G., Vinci P., Borghi C., D'Addato S., Bossi A.C., Meregalli G., Branchi A., Squiccimarro G., Cavalot F., Ramadori L., Cipollone F., Bucci M., Del Ben M., Angelico F., Fiorenza A.M., Colombo E., Grigore L., Zampoleri V., Lupattelli G., Gandolfo V., Mandraffino G., Savarino F., Mombelli G., Pavanello C., Pisciotta L., Pasta A., Purrello F., Scicali R., Rubba P., Fortunato G., Sabba C., Suppressa P., Sarzani R., Di Pentima C., Vigna G.B., Colangiulo A., Werba J.P., Vigo L.M., Zambon S., Previato L., Zenti M.G., and Maneschi C.
Subjects: 0301 basic medicine, Male, medicine.medical_specialty, Settore MED/09 - Medicina Interna, adverse effects, myopathy, statin-associated muscle symptoms, statins, 030204 cardiovascular system & hematology, Medication Adherence, 03 medical and health sciences, 0302 clinical medicine, Muscular Diseases, Internal medicine, adverse effect, Internal Medicine, medicine, Prevalence, Humans, statin‐associated muscle symptoms, Adverse effect, Dechallenge, Creatine Kinase, Dyslipidemias, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Italy, Middle Aged, Retrospective Studies, business.industry, Retrospective cohort study, Odds ratio, Original Articles, Confidence interval, Discontinuation, 030104 developmental biology, Concomitant, Cohort, Original Article, business, statin-associated muscle symptom
Abstract: Aim: Statin-associated muscle symptoms (SAMS) are a major determinant of poor treatment adherence and/or discontinuation, but a definitive diagnosis of SAMS is challenging. The PROSISA study was an observational retrospective study aimed to assess the prevalence of reported SAMS in a cohort of dyslipidaemic patients. Methods: Demographic/anamnestic data, biochemical values and occurrence of SAMS were collected by 23 Italian Lipid Clinics. Adjusted logistic regression was performed to estimate odds ratio (OR) and 95% confidence intervals for association between probability of reporting SAMS and several factors. Results: Analyses were carried out on 16717 statin-treated patients (mean±SD, age 60.5±12.0years; 52.1% men). During statin therapy, 9.6% (N=1599) of patients reported SAMS. Women and physically active subjects were more likely to report SAMS (OR 1.23 [1.10–1.37] and OR 1.35 [1.14–1.60], respectively), whist age≥65 (OR 0.79 [0.70–0.89]), presence of type 2 diabetes mellitus (OR 0.62 [0.51–0.74]), use of concomitant nonstatin lipid-lowering drugs (OR 0.87 [0.76–0.99]), use of high-intensity statins (OR 0.79 [0.69–0.90]) and use of potential interacting drugs (OR 0.63 [0.48–0.84]) were associated with lower probability of reporting SAMS. Amongst patients reporting SAMS, 82.2% underwent dechallenge (treatment interruption) and/or rechallenge (change or restart of statin therapy), with reappearance of muscular symptoms in 38.4% (3.01% of the whole cohort). Conclusions: The reported prevalence of SAMS was 9.6% of the whole PROSISA cohort, but only a third of patients still reported SAMS after dechallenge/rechallenge. These results emphasize the need for a better management of SAMS to implement a more accurate diagnosis and treatment re-evaluation.
Published: 2020

13. CHANGES IN BLOOD PRESSURE AND RENAL FUNCTION IN PATIENTS WITH HEART FAILURE AND REDUCED EJECTION FRACTION TAKING SACUBITRIL/VALSARTAN: A 1-YEAR FOLLOW-UP STUDY IN THE REAL WORLD

Author: Spannella, F., Giulietti, F., Di Pentima, C., Filipponi, A., Marini, M., Francioni, M., Perna, G., and Sarzani, R.
Published: 2019
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14. May Measurement Month 2019: An analysis of blood pressure screening results from Italy

Author: Torlasco, C, Faini, A, Pengo, M, Borghi, C, Grassi, G, Ferri, C, Muiesan, M, Salvetti, M, Sechi, L, Minuz, P, Mulatero, P, Pucci, G, Volpe, M, Carugo, S, Sarzani, R, Mule, G, Beaney, T, Poulter, N, Xia, X, Parati, G, Torlasco C., Faini A., Pengo M., Borghi C., Grassi G., Ferri C., Muiesan M. L., Salvetti M., Sechi L., Minuz P., Mulatero P., Pucci G., Volpe M., Carugo S., Sarzani R., Mule G., Beaney T., Poulter N. R., Xia X., Parati G., Torlasco, C, Faini, A, Pengo, M, Borghi, C, Grassi, G, Ferri, C, Muiesan, M, Salvetti, M, Sechi, L, Minuz, P, Mulatero, P, Pucci, G, Volpe, M, Carugo, S, Sarzani, R, Mule, G, Beaney, T, Poulter, N, Xia, X, Parati, G, Torlasco C., Faini A., Pengo M., Borghi C., Grassi G., Ferri C., Muiesan M. L., Salvetti M., Sechi L., Minuz P., Mulatero P., Pucci G., Volpe M., Carugo S., Sarzani R., Mule G., Beaney T., Poulter N. R., Xia X., and Parati G.
Abstract: Cardiovascular (CV) diseases are burdened by high mortality and morbidity, being responsible for half of the deaths in Europe. Although hypertension is recognized as the most important CV risk factor, hypertension awareness, and blood pressure (BP) control are still unsatisfactory. In 2017 and 2018, respectively >10 000 and >5000 individuals took part in the May Measurement Month (MMM) campaign in Italy, of whom 30.6% and 26.3% were found to have high BP, respectively. To raise public awareness on the importance of hypertension and to collect BP data on a nation-wide scale in Italy. In the frame of the MMM campaign, an opportunistic cross-sectional survey of volunteers aged ≥18 years was carried out in May 2019. BP measurement, the definition of hypertension, and statistical analysis followed the standard MMM protocol. Screening was conducted in multiple sites by health personnel. Among the 10 182 people screened (females: 52.3%, mean age 58 ± 16years) mean BP was 127/78 mmHg, and 3171 (31.1%) participants had arterial hypertension, of whom 62.1% were aware of being hypertensive. Diabetes, body mass index >25 kg/m2 were associated with higher BP and previous myocardial infarction with lower BP. For the third consecutive year we collected a nation-wide snapshot of BP control in a large sample of individuals. The high participation, with some yearly fluctuations likely due to the limitations of the sampling technique, confirms the power of this kind of health campaign in reaching a significant number of people to raise awareness on health topics.
Published: 2021

15. Impact of SCORE2 on cardiovascular risk reclassification and prevalence of LDL-cholesterol control according to most recent equations in a wide hypertensive population

Author: Sarzani, R., primary, Giulietti, F., additional, Allevi, M., additional, Turri, P., additional, Sarnari, S., additional, Re, S., additional, and Spannella, F., additional
Published: 2022
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16. Adiposity and insulin resistance linked to non-HDL cholesterol and apolipoprotein B-100: A cross-sectional study in a hypertensive population

Author: Sarzani, R., primary, Giulietti, F., additional, Biondini, S., additional, Fausti, E., additional, Allevi, M., additional, and Spannella, F., additional
Published: 2022
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17. Covid-19 and the role of smoking: The protocol of the multicentric prospective study COSMO-IT (covid19 and smoking in italy)

Author: Cattaruzza, M, Gorini, G, Bosetti, C, Boffi, R, Lugo, A, Veronese, C, Carreras, G, Santucci, C, Stival, C, Pacifici, R, Zaga, V, Gallus, S, Giulietti, F, Sarzani, R, Spannella, F, Del Donno, M, Tartaglione, S, Marrazzo, G, Pelaia, G, D'Agosto, V, Berti, A, Voller, F, Cardellicchio, S, Cresci, C, Foschino Barbaro, M, De Palma, R, Negrini, S, Sicbaldi, V, Serafini, A, Bisconti, M, Refolo, L, Landoni, G, Rovere, P, Veronesi, G, Faverio, P, Garavello, W, Pesci, A, Giacobbe, R, Martucci, P, Parrella, R, Scarano, F, Aiello, M, Chetta, A, Franco, C, Mangia, A, Carrozzi, L, Maggi Monzani, F, Pistelli, F, Russo, P, Sanna, A, Barreca, F, Conti, V, Rossi, E, Ruli, M, Ruli, S, Varzaneh, S, Principe, R, Guerrini, S, Sebastiani, A, Galluccio, G, Pezzuto, A, Ricci, A, Casali, E, Mastroianni, C, Pirina, P, Polo, F, Beatrice, F, Romagnoli, M, Baraldo, M, Cojutti, P, Graziano, E, Pecori, D, Tascini, C, Tinghino, B, Cattaruzza M. S., Gorini G., Bosetti C., Boffi R., Lugo A., Veronese C., Carreras G., Santucci C., Stival C., Pacifici R., Zaga V., Gallus S., Giulietti F., Sarzani R., Spannella F., Del Donno M., Tartaglione S., Marrazzo G., Pelaia G., D'agosto V., Berti A., Voller F., Cardellicchio S., Cresci C., Foschino Barbaro M. P., De Palma R., Negrini S., Sicbaldi V., Serafini A., Bisconti M., Refolo L., Landoni G., Rovere P., Veronesi G., Faverio P., Garavello W., Pesci A., Giacobbe R., Martucci P., Parrella R., Scarano F., Aiello M., Chetta A., Franco C., Mangia A., Carrozzi L., Maggi Monzani F. F., Pistelli F., Russo P., Sanna A., Barreca F. M., Conti V., Rossi E., Ruli M., Ruli S., Varzaneh S. E., Principe R., Guerrini S., Sebastiani A., Galluccio G., Pezzuto A., Ricci A., Casali E., Mastroianni C., Pirina P., Polo F., Beatrice F., Romagnoli M., Baraldo M., Cojutti P. G., Graziano E., Pecori D., Tascini C., Tinghino B., Cattaruzza, M, Gorini, G, Bosetti, C, Boffi, R, Lugo, A, Veronese, C, Carreras, G, Santucci, C, Stival, C, Pacifici, R, Zaga, V, Gallus, S, Giulietti, F, Sarzani, R, Spannella, F, Del Donno, M, Tartaglione, S, Marrazzo, G, Pelaia, G, D'Agosto, V, Berti, A, Voller, F, Cardellicchio, S, Cresci, C, Foschino Barbaro, M, De Palma, R, Negrini, S, Sicbaldi, V, Serafini, A, Bisconti, M, Refolo, L, Landoni, G, Rovere, P, Veronesi, G, Faverio, P, Garavello, W, Pesci, A, Giacobbe, R, Martucci, P, Parrella, R, Scarano, F, Aiello, M, Chetta, A, Franco, C, Mangia, A, Carrozzi, L, Maggi Monzani, F, Pistelli, F, Russo, P, Sanna, A, Barreca, F, Conti, V, Rossi, E, Ruli, M, Ruli, S, Varzaneh, S, Principe, R, Guerrini, S, Sebastiani, A, Galluccio, G, Pezzuto, A, Ricci, A, Casali, E, Mastroianni, C, Pirina, P, Polo, F, Beatrice, F, Romagnoli, M, Baraldo, M, Cojutti, P, Graziano, E, Pecori, D, Tascini, C, Tinghino, B, Cattaruzza M. S., Gorini G., Bosetti C., Boffi R., Lugo A., Veronese C., Carreras G., Santucci C., Stival C., Pacifici R., Zaga V., Gallus S., Giulietti F., Sarzani R., Spannella F., Del Donno M., Tartaglione S., Marrazzo G., Pelaia G., D'agosto V., Berti A., Voller F., Cardellicchio S., Cresci C., Foschino Barbaro M. P., De Palma R., Negrini S., Sicbaldi V., Serafini A., Bisconti M., Refolo L., Landoni G., Rovere P., Veronesi G., Faverio P., Garavello W., Pesci A., Giacobbe R., Martucci P., Parrella R., Scarano F., Aiello M., Chetta A., Franco C., Mangia A., Carrozzi L., Maggi Monzani F. F., Pistelli F., Russo P., Sanna A., Barreca F. M., Conti V., Rossi E., Ruli M., Ruli S., Varzaneh S. E., Principe R., Guerrini S., Sebastiani A., Galluccio G., Pezzuto A., Ricci A., Casali E., Mastroianni C., Pirina P., Polo F., Beatrice F., Romagnoli M., Baraldo M., Cojutti P. G., Graziano E., Pecori D., Tascini C., and Tinghino B.
Abstract: The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT). About 30 Italian hospitals in North, Centre and South of Italy joined the study. Its main aims are: 1) to quantify the role of tobacco smoking and smoking cessation on the severity and progression of COVID-19 in hospitalized patients; 2) to compare smoking prevalence and severity of the disease in relation to smoking in hospitalized COVID-19 patients versus patients treated at home; 3) to quantify the association between other lifestyle factors, such as e-cigarette and HTP use, alcohol and obesity and the risk of unfavourable COVID-19 outcomes. Socio-demographic, lifestyle and medical history information will be gathered for around 3000 hospitalized and 700-1000 home-isolated, laboratory-confirmed, COVID-19 patients. Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for COVID-19, prevention strategies are of extreme importance. This project, designed to highly contribute to the international scientific debate on the role of avoidable lifestyle habits on COVID-19 severity, will provide valuable epidemiological data in order to support important recommendations to prevent COVID-19 incidence, progression and mortality.
Published: 2020

18. The corona-virus disease 2019 pandemic compromised routine care for hypertension: a survey conducted among excellence centers of the European Society of Hypertension

Author: Weber, T, Januszewicz, A, Rosei, Ea, Tsioufis, K, Okorie, M, Stergiou, Gs, Volpe, M, Kreutz, R, Abraham, G, Azizi, M, Barna, I, Barroso, Wks, Brguljan, J, Chapman, N, De Backer, T, Dorobantu, M, Eckert, S, Gaciong, Z, Giannattasio, C, Glover, M, Gottsater, A, Grassos, C, Jarai, Z, Aguila, Fj, Kahan, T, Lopez-Sublet, M, Lovic, D, Lurbe, E, Makris, Tk, Mallamaci, F, Manolis, Aj, Marketou, M, Mazza, A, Mediavilla, Jd, Muiesan, Ml, Muxfeldt, Es, Nasr, E, Papadakis, I, Parounak, Z, Obregon, S, Oliveras, A, Pontremoli, R, Raev, D, Rajkumar, C, Redon, J, Robles, Nr, Rump, Lc, Sarzani, R, Sierra, C, Sirenko, Y, Stojanov, V, Tikkanen, I, Vaclavik, J, Veglio, F, Viigimaa, M, Webb, D, Zebekakis, P, and Zweiker, R
Subjects: medicine.medical_specialty, Ambulatory blood pressure, Coronavirus disease 2019 (COVID-19), Physiology, media_common.quotation_subject, Shutdown, Angiotensin-Converting Enzyme Inhibitors, Covid-19, blood pressure, hypertension routine care, renin-angiotensin system inhibitors, Angiotensin Receptor Antagonists, Antihypertensive Agents, Blood Pressure Monitoring, Ambulatory, COVID-19, Delivery of Health Care, Europe, Humans, Hypertension, Renin-Angiotensin System, SARS-CoV-2, Surveys and Questionnaires, Health Facilities, Health Services Accessibility, Pandemics, Virus diseases, Blood Pressure Monitoring, Excellence, Ambulatory, Pandemic, Internal Medicine, Medicine, Routine care, media_common, business.industry, Blood pressure, Emergency medicine, angiotensin receptor antagonists, angiotensin-converting enzyme inhibitors, antihypertensive agents, blood pressure monitoring, ambulatory, delivery of health care, humans, hypertension, renin-angiotensin system, surveys and questionnaires, health facilities, health services accessibility, pandemics, Cardiology and Cardiovascular Medicine, business
Abstract: Background: The Covid-19 pandemic caused a shutdown of healthcare systems in many countries. We explored the impact on hypertension care in the Excellence Center (EC) network of the European Society of Hypertension. Methods: We conducted a 17-question electronic survey among ECs. Results: Overall, 52 ECs from 20 European and three non-European countries participated, providing hypertension service for a median of 1500 hypertensive patients per center per year. Eighty-five percent of the ECs reported a shutdown lasting for 9 weeks (range 0–16). The number of patients treated per week decreased by 90%: from a median of 50 (range 10–400) before the pandemic to a median of 5.0 (range 0–150) during the pandemic (P < 0.0001). 60% of patients (range 0–100%) declared limited access to medical consultations. The majority of ECs (57%) could not provide 24-h ambulatory BP monitoring, whereas a median of 63% (range 0–100%) of the patients were regularly performing home BP monitoring. In the majority (75%) of the ECs, hypertension service returned to normal after the first wave of the pandemic. In 66% of the ECs, the physicians received many questions regarding the use of renin–angiotensin system (RAS) blockers. Stopping RAS-blocker therapy (in a few patients) either by patients or physicians was reported in 27 and 36.5% of the ECs. Conclusion: Patient care in hypertension ECs was compromised during the Covid-19-related shutdown. These data highlight the necessity to develop new strategies for hypertension care including virtual clinics to maintain services during challenging times.
Published: 2021

19. Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension

Author: Iaccarino G, Grassi G, Borghi C, Carugo S, Fallo F, Ferri C, Giannattasio C, Grassi D, Letizia C, Mancusi C, Minuz P, Perlini S, Pucci G, Rizzoni D, Salvetti M, Sarzani R, Sechi L, Veglio F, Volpe M, Muiesan ML, SARS-RAS Investigators, Iaccarino G, Grassi G, Borghi C, Carugo S, Fallo F, Ferri C, Giannattasio C, Grassi D, Letizia C, Mancusi C, Minuz P, Perlini S, Pucci G, Rizzoni D, Salvetti M, Sarzani R, Sechi L, Veglio F, Volpe M, Muiesan ML, SARS-RAS Investigators, Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, Iaccarino, G., Borghi, C., Carugo, S., Fallo, F., Ferri, C., Giannattasio, C., Grassi, D., Letizia, C., Mancusi, C., Minuz, P., Perlini, S., Pucci, G., Rizzoni, D., Salvetti, M., Sarzani, R., Sechi, L., Veglio, F., Volpe, M., Muiesan, M. L., and SARS-RAS Investigator
Subjects: COVID-19, gender, obesity, Male, Pulmonology, Cross-sectional study, Disease, Cardiovascular Medicine, covid , gender, Vascular Medicine, Severity of Illness Index, Covid, law.invention, Adolescent, Adult, Aged, Aged, 80 and over, Betacoronavirus, Coronavirus Infections, Cross-Sectional Studies, Female, Heart Failure, Humans, Hypertension, Italy, Middle Aged, Obesity, Pandemics, Pneumonia, Viral, Renal Insufficiency, Chronic, Risk Factors, Sex Factors, Young Adult, Intensive Care Units, Patient Admission, 0302 clinical medicine, Medical Conditions, Endocrinology, Health care, 80 and over, Medicine, Chronic, Nephrology, Cardiovascular Diseases, Human, medicine.medical_specialty, Endocrine Disorders, Science, Intensive Care Unit, COVID-19, SARS-CoV-2, 03 medical and health sciences, Intensive care, Severity of illness, Renal Diseases, Diabetes Mellitus, Cross-Sectional Studie, Betacoronaviru, Biology and Life Sciences, Correction, Covid 19, Pneumonia, Clinical trial, Health Care, Health Care Facilities, Observational study, SARS_CoV-2, Viral Diseases, Physiology, Sex Factor, 030204 cardiovascular system & hematology, law, Chronic Kidney Disease, Medicine and Health Sciences, Coronary Heart Disease, 030212 general & internal medicine, Viral, Renal Insufficiency, intensive care, Multidisciplinary, SARS_CoV-2, Gender, intensive care, prediction, Intensive care unit, Hospitals, Infectious Diseases, Physiological Parameters, Research Article, Chronic Obstructive Pulmonary Disease, Cardiology, Pandemic, business.industry, Coronavirus Infection, Risk Factor, Body Weight, Gender, prediction, Hyperyension, Metabolic Disorders, Emergency medicine, business
Abstract: BackgroundThe global rate of intensive care unit (ICU) admission during the COVID-19 pandemic varies within countries and is among the main challenges for health care systems worldwide. Conflicting results have been reported about the response to coronavirus infection and COVID-19 outcomes in men and women. Understanding predictors of intensive care unit admission might be of help for future planning and management of the disease.Methods and findingsWe designed a cross-sectional observational multicenter nationwide survey in Italy to understand gender-related clinical predictors of ICU admission in patients with COVID-19. We analyzed information from 2378 charts of Italian patients certified for COVID-19 admitted in 26 hospitals. Three hundred ninety-five patients (16.6%) required ICU admission due to COVID19 infection, more frequently men (74%), with a higher prevalence of comorbidities (1,78±0,06 vs 1,54±0,03 pConclusionsOur study demonstrates that gender is the primary determinant of the disease's severity among COVID-19. Obesity is the condition more often observed among those admitted to ICU within both genders.Trial registrationClinicaltrials.gov: NCT04331574.
Published: 2020

20. World Hypertension Day 2021 in Italy: Results of a Nationwide Survey

Author: Del Pinto, R, Grassi, G, Lorenza Muiesan, M, Borghi, C, Carugo, S, Cicero, A, Di Meo, L, Iaccarino, G, Minuz, P, Mulatero, P, Mulè, G, Parati, G, Pucci, G, Salvetti, M, Sarzani, R, Savoia, C, Sechi, L, Tocci, G, Volpe, M, Vulpis, V, Ferri, C, Rita Del Pinto, Guido Grassi, Maria Lorenza Muiesan, Claudio Borghi, Stefano Carugo, Arrigo F. G. Cicero, Luciano Di Meo, Guido Iaccarino, Pietro Minuz, Paolo Mulatero, Giuseppe Mulè, Gianfranco Parati, Giacomo Pucci, Massimo Salvetti, Riccardo Sarzani, Carmine Savoia, Leonardo Sechi, Giuliano Tocci, Massimo Volpe, Vito Vulpis, Claudio Ferri, Del Pinto, R, Grassi, G, Lorenza Muiesan, M, Borghi, C, Carugo, S, Cicero, A, Di Meo, L, Iaccarino, G, Minuz, P, Mulatero, P, Mulè, G, Parati, G, Pucci, G, Salvetti, M, Sarzani, R, Savoia, C, Sechi, L, Tocci, G, Volpe, M, Vulpis, V, Ferri, C, Rita Del Pinto, Guido Grassi, Maria Lorenza Muiesan, Claudio Borghi, Stefano Carugo, Arrigo F. G. Cicero, Luciano Di Meo, Guido Iaccarino, Pietro Minuz, Paolo Mulatero, Giuseppe Mulè, Gianfranco Parati, Giacomo Pucci, Massimo Salvetti, Riccardo Sarzani, Carmine Savoia, Leonardo Sechi, Giuliano Tocci, Massimo Volpe, Vito Vulpis, and Claudio Ferri
Abstract: Introduction: Hypertension is the biggest contributor to the global burden of cardiovascular diseases and related death, but the rates of hypertension awareness, treatment, and control remain largely perfectible. Methods: During the XVII World Hypertension Day (May 17th, 2021), a nationwide cross-sectional opportunistic study endorsed by the Italian Society of Hypertension was conducted on volunteer adults ≥ 18 years to raise awareness of high blood pressure (BP). A questionnaire on major demographic/clinical features (sex, age, employment, education, BP status awareness, hypertension family/personal history, antihypertensive medications use) and BP measurement habits (≥1 BP measurement in the previous month/week) was administered. Due to the ongoing SARS-CoV-2 pandemic, BP was measured with standard procedures in a subset of participants (24.4%). Results: A total of 1354 participants (mean age 56.3 ± 15.3 years; 57.3% women; mean BP: 131.2 ± 17.5/81.6 ± 10.5 mmHg; 42.3% self-declared hypertensive; 41.4% on antihypertensive medications) were enrolled; 73.6% declared being aware of their BP status. Among treated individuals with measured BP, 26.9% showed BP levels within the predefined therapeutic goals. Interestingly, BP status awareness rates were the highest among individuals with uncontrolled hypertension (85.1%) and the lowest among those with normal measured BP (54.4%). Conclusions: This survey provides an updated insight into hypertension awareness and control in a setting of daily clinical practice, emphasizing the centricity of patients in the therapeutic alliance for a successful reduction of cardiovascular risk.
Published: 2022

21. Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

Author: Scichilone, N, Antonelli Incalzi, R, Blasi, F, Schino, P, Cuttitta, G, Zullo, A, Ori, A, Canonica, G, Foschino, M, Prediletto, R, Tranfa, C, Zappa, M, Patriciello, P, Labate, L, Mariotta, S, Nava, S, Vatrella, A, Mastroberardino, M, Sarzani, R, Iuliano, A, Maggi, L, Zedda, A, Pesci, A, Sera, G, Nicolini, A, Salvatore Walter, D, Forte, S, Mario, D, Rivolta, F, Ferliga, M, Raco, A, Luigi, D, Cabibbo, G, Maselli, R, Gulotta, C, Nardini, S, Guffanti, E, Castellani, W, Triolo, L, Passalacqua, G, Beghe, B, Salvatore, L, Faccini, E, Atzeni, E, Tazza, R, Giamesio, P, Scichilone N., Antonelli Incalzi R., Blasi F., Schino P., Cuttitta G., Zullo A., Ori A., Canonica G., Foschino M. P., Prediletto R., Tranfa C. M. E., Zappa M. C., Patriciello P., Labate L., Mariotta S., Nava S., Vatrella A., Mastroberardino M., Sarzani R., Iuliano A., Maggi L., Zedda A., Pesci A., Sera G., Nicolini A., Salvatore Walter D. D., Forte S., Mario D. D., Rivolta F., Ferliga M., Raco A. F., Luigi D. R., Cabibbo G., Maselli R., Gulotta C., Nardini S., Guffanti E. E., Castellani W., Triolo L., Passalacqua G., Beghe B., Salvatore L. C., Faccini E., Atzeni E., Tazza R., Giamesio P., Scichilone, N, Antonelli Incalzi, R, Blasi, F, Schino, P, Cuttitta, G, Zullo, A, Ori, A, Canonica, G, Foschino, M, Prediletto, R, Tranfa, C, Zappa, M, Patriciello, P, Labate, L, Mariotta, S, Nava, S, Vatrella, A, Mastroberardino, M, Sarzani, R, Iuliano, A, Maggi, L, Zedda, A, Pesci, A, Sera, G, Nicolini, A, Salvatore Walter, D, Forte, S, Mario, D, Rivolta, F, Ferliga, M, Raco, A, Luigi, D, Cabibbo, G, Maselli, R, Gulotta, C, Nardini, S, Guffanti, E, Castellani, W, Triolo, L, Passalacqua, G, Beghe, B, Salvatore, L, Faccini, E, Atzeni, E, Tazza, R, Giamesio, P, Scichilone N., Antonelli Incalzi R., Blasi F., Schino P., Cuttitta G., Zullo A., Ori A., Canonica G., Foschino M. P., Prediletto R., Tranfa C. M. E., Zappa M. C., Patriciello P., Labate L., Mariotta S., Nava S., Vatrella A., Mastroberardino M., Sarzani R., Iuliano A., Maggi L., Zedda A., Pesci A., Sera G., Nicolini A., Salvatore Walter D. D., Forte S., Mario D. D., Rivolta F., Ferliga M., Raco A. F., Luigi D. R., Cabibbo G., Maselli R., Gulotta C., Nardini S., Guffanti E. E., Castellani W., Triolo L., Passalacqua G., Beghe B., Salvatore L. C., Faccini E., Atzeni E., Tazza R., and Giamesio P.
Abstract: Background: Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods: The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George's Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded. Results: 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression. Conclusions: The findings highlight the primary classificatory role of nocturnal symptoms in COPD. Trial registration: Trial registration number: NCT03105999, date of registration: 10th April 2017.
Published: 2019

22. Validation of an easy questionnaire on the assessment of salt habit: the MINISAL-SIIA Study Program

Author: D'Elia, L, Manfredi, M, Strazzullo, P, Galletti, F, Agabiti-Rosei, E, Arcangeli, E, Artom, A, Barbato, A, Barbiero, M, Belfiore, A, Bernini, G, Boero, R, Berra, E, Biggi, A, Borgheresi, P, Borghi, C, Bosio, A, Caiazza, A, Caielli, P, Calo, L, Castellano, M, Catena, C, Cerrato, F, Cilia, C, Cipollini, F, Crippa, M, Cuspidi, C, D'Avino, M, De Giorgi, G, De Luca, N, De Pergola, G, Del Giudice, A, Desideri, G, Fallo, F, Ferri, C, Galeone, D, Garavelli, G, Gaudio, G, Giacchetti, G, Gidaro, B, Giovannetti, R, Grandi, A, Guglielmi, M, Iacoviello, L, Leonardis, D, Lonati, C, Lonati, L, Malatino, L, Mallamaci, F, Maresca, A, Marzano, L, Massara, C, Merletti, L, Meschi, M, Modesti, S, Montanari, A, Morganti, A, Musiari, L, Musso, N, Nardecchia, A, Nazzaro, P, Pallisco, O, Panichi, V, Parati, G, Pascale, C, Pini, C, Pirola, I, Pucci, G, Rabbia, F, Rescaldani, M, Ronchi, E, Rossi, E, Rossi, G, Sala, C, Sarzani, R, Sechi, L, Silvestris, F, Stancanelli, B, Trimarco, B, Ungar, A, Veglio, F, Veronesi, M, Vinella, L, D'Elia L., Manfredi M., Strazzullo P., Galletti F., Agabiti-Rosei E., Arcangeli E., Artom A., Barbato A., Barbiero M., Belfiore A., Bernini G., Boero R., Berra E., Biggi A., Borgheresi P., Borghi C., Bosio A., Caiazza A., Caielli P., Calo L. A., Castellano M., Catena C., Cerrato F., Cilia C., Cipollini F., Crippa M., Cuspidi C., D'Avino M., De Giorgi G. A., De Luca N., De Pergola G., Del Giudice A., Desideri G., Fallo F., Ferri C., Galeone D., Garavelli G., Gaudio G., Giacchetti G., Gidaro B., Giovannetti R., Grandi A., Guglielmi M., Iacoviello L., Leonardis D., Lonati C., Lonati L. M., Malatino L., Mallamaci F., Maresca A. M., Marzano L., Massara C., Merletti L., Meschi M., Modesti S., Montanari A., Morganti A., Musiari L., Musso N., Nardecchia A., Nazzaro P., Pallisco O., Panichi V., Parati G., Pascale C., Pini C., Pirola I., Pucci G., Rabbia F., Rescaldani M., Ronchi E., Rossi E., Rossi G., Sala C., Sarzani R., Sechi L. A., Silvestris F., Stancanelli B., Trimarco B., Ungar A., Veglio F., Veronesi M., Vinella L., D'Elia, L, Manfredi, M, Strazzullo, P, Galletti, F, Agabiti-Rosei, E, Arcangeli, E, Artom, A, Barbato, A, Barbiero, M, Belfiore, A, Bernini, G, Boero, R, Berra, E, Biggi, A, Borgheresi, P, Borghi, C, Bosio, A, Caiazza, A, Caielli, P, Calo, L, Castellano, M, Catena, C, Cerrato, F, Cilia, C, Cipollini, F, Crippa, M, Cuspidi, C, D'Avino, M, De Giorgi, G, De Luca, N, De Pergola, G, Del Giudice, A, Desideri, G, Fallo, F, Ferri, C, Galeone, D, Garavelli, G, Gaudio, G, Giacchetti, G, Gidaro, B, Giovannetti, R, Grandi, A, Guglielmi, M, Iacoviello, L, Leonardis, D, Lonati, C, Lonati, L, Malatino, L, Mallamaci, F, Maresca, A, Marzano, L, Massara, C, Merletti, L, Meschi, M, Modesti, S, Montanari, A, Morganti, A, Musiari, L, Musso, N, Nardecchia, A, Nazzaro, P, Pallisco, O, Panichi, V, Parati, G, Pascale, C, Pini, C, Pirola, I, Pucci, G, Rabbia, F, Rescaldani, M, Ronchi, E, Rossi, E, Rossi, G, Sala, C, Sarzani, R, Sechi, L, Silvestris, F, Stancanelli, B, Trimarco, B, Ungar, A, Veglio, F, Veronesi, M, Vinella, L, D'Elia L., Manfredi M., Strazzullo P., Galletti F., Agabiti-Rosei E., Arcangeli E., Artom A., Barbato A., Barbiero M., Belfiore A., Bernini G., Boero R., Berra E., Biggi A., Borgheresi P., Borghi C., Bosio A., Caiazza A., Caielli P., Calo L. A., Castellano M., Catena C., Cerrato F., Cilia C., Cipollini F., Crippa M., Cuspidi C., D'Avino M., De Giorgi G. A., De Luca N., De Pergola G., Del Giudice A., Desideri G., Fallo F., Ferri C., Galeone D., Garavelli G., Gaudio G., Giacchetti G., Gidaro B., Giovannetti R., Grandi A., Guglielmi M., Iacoviello L., Leonardis D., Lonati C., Lonati L. M., Malatino L., Mallamaci F., Maresca A. M., Marzano L., Massara C., Merletti L., Meschi M., Modesti S., Montanari A., Morganti A., Musiari L., Musso N., Nardecchia A., Nazzaro P., Pallisco O., Panichi V., Parati G., Pascale C., Pini C., Pirola I., Pucci G., Rabbia F., Rescaldani M., Ronchi E., Rossi E., Rossi G., Sala C., Sarzani R., Sechi L. A., Silvestris F., Stancanelli B., Trimarco B., Ungar A., Veglio F., Veronesi M., and Vinella L.
Abstract: Background/objectives: The aim of the present study was to validate a short questionnaire on habitual dietary salt intake, to quickly and easily identify individuals whose salt consumption exceeds recommended levels. Subjects/methods: A total of 1131 hypertensive subjects participating in the MINISAL-SIIA study were included in the analysis. Anthropometric indexes, blood pressure, and 24-h urinary sodium excretion (NaU) were measured. A fixed-sequence questionnaire on dietary salt intake was administered. Results: NaU was significantly associated with scores, with a linear association across categories (p for trend <0.0001). In addition, participants who achieved a total score above the median value (eight points) had significantly higher NaU than those whose score was below median (p < 0.0001). In the total sample, the prevalence of “high NaU” (NaU > 85 mmol/day) and “very high NaU” (NaU > 170 mmol/day) was 86 and 35%, respectively. The score of the questionnaire had a significant ability to detect both “high NaU”—with a specificity of 95% at the score of 10 points—and “very high NaU”—with a specificity of 99.6% at score of 13 points. Conclusions: The main results of the study indicates that a higher score of this short questionnaire is distinctive of habitual high salt consumption in hypertensive patients.
Published: 2019

23. Ambulatory blood pressure and arterial stiffness web-based telemonitoring in patients at cardiovascular risk. First results of the VASOTENS (Vascular health ASsessment Of The hypertENSive patients) Registry

Author: Omboni, S, Posokhov, I, Parati, G, Rogoza, A, Kotovskaya, Y, Arystan, A, Avolio, A, Barkan, V, Bulanova, N, Cardona Munoz, E, Grigoricheva, E, Konradi, A, Minyukhina, I, Muiesan, M, Mule, G, Orlova, I, Pereira, T, Peixoto Maldonado, J, Statsenko, M, Tilea, I, Waisman, G, Forcada, P, Zelveian, P, Butlin, M, Barin, E, Tan, I, Ghiadoni, L, Bruno, R, Sarzani, R, Espinosa, E, Volpe, M, Savoia, C, Tocci, G, Borghi, C, Schillaci, G, Pucci, G, Paini, A, Rizzoni, D, Ramos, C, Alanis, A, Varga, A, Volkov, D, Kurlykina, N, Rotar, O, Orlov, A, Gorbunov, V, Boytsov, S, Fedorova, E, Korneva, V, Kuznetsova, T, Kulikova, N, Evdokimov, V, Kuznetsova, A, Zheleznyak, E, Kobalava, Z, Borisova, I, Svetozarsky, T, Gubanova, M, Lazareva, V, Derevyanchenko, M, Kopylov, P, Sirenko, Y, Recovets, O, Omboni S., Posokhov I., Parati G., Rogoza A., Kotovskaya Y., Arystan A., Avolio A., Barkan V., Bulanova N., Cardona Munoz E., Grigoricheva E., Konradi A., Minyukhina I., Muiesan M. L., Mule G., Orlova I., Pereira T., Peixoto Maldonado J. M., Statsenko M. E., Tilea I., Waisman G., Forcada P., Zelveian P., Butlin M., Barin E., Tan I., Ghiadoni L., Bruno R. M., Sarzani R., Espinosa E., Volpe M., Savoia C., Tocci G., Borghi C., Schillaci G., Pucci G., Paini A., Rizzoni D., Ramos C., Alanis A., Varga A., Volkov D., Kurlykina N., Rotar O., Orlov A., Gorbunov V., Boytsov S., Fedorova E., Korneva V., Kuznetsova T., Kulikova N., Evdokimov V. V., Kuznetsova A., Zheleznyak E., Kobalava Z., Borisova I., Svetozarsky T., Gubanova M., Lazareva V., Derevyanchenko M. V., Kopylov P., Sirenko Y., Recovets O., Omboni, S, Posokhov, I, Parati, G, Rogoza, A, Kotovskaya, Y, Arystan, A, Avolio, A, Barkan, V, Bulanova, N, Cardona Munoz, E, Grigoricheva, E, Konradi, A, Minyukhina, I, Muiesan, M, Mule, G, Orlova, I, Pereira, T, Peixoto Maldonado, J, Statsenko, M, Tilea, I, Waisman, G, Forcada, P, Zelveian, P, Butlin, M, Barin, E, Tan, I, Ghiadoni, L, Bruno, R, Sarzani, R, Espinosa, E, Volpe, M, Savoia, C, Tocci, G, Borghi, C, Schillaci, G, Pucci, G, Paini, A, Rizzoni, D, Ramos, C, Alanis, A, Varga, A, Volkov, D, Kurlykina, N, Rotar, O, Orlov, A, Gorbunov, V, Boytsov, S, Fedorova, E, Korneva, V, Kuznetsova, T, Kulikova, N, Evdokimov, V, Kuznetsova, A, Zheleznyak, E, Kobalava, Z, Borisova, I, Svetozarsky, T, Gubanova, M, Lazareva, V, Derevyanchenko, M, Kopylov, P, Sirenko, Y, Recovets, O, Omboni S., Posokhov I., Parati G., Rogoza A., Kotovskaya Y., Arystan A., Avolio A., Barkan V., Bulanova N., Cardona Munoz E., Grigoricheva E., Konradi A., Minyukhina I., Muiesan M. L., Mule G., Orlova I., Pereira T., Peixoto Maldonado J. M., Statsenko M. E., Tilea I., Waisman G., Forcada P., Zelveian P., Butlin M., Barin E., Tan I., Ghiadoni L., Bruno R. M., Sarzani R., Espinosa E., Volpe M., Savoia C., Tocci G., Borghi C., Schillaci G., Pucci G., Paini A., Rizzoni D., Ramos C., Alanis A., Varga A., Volkov D., Kurlykina N., Rotar O., Orlov A., Gorbunov V., Boytsov S., Fedorova E., Korneva V., Kuznetsova T., Kulikova N., Evdokimov V. V., Kuznetsova A., Zheleznyak E., Kobalava Z., Borisova I., Svetozarsky T., Gubanova M., Lazareva V., Derevyanchenko M. V., Kopylov P., Sirenko Y., and Recovets O.
Abstract: The VASOTENS Registry is an international telehealth-based repository of 24-hour ambulatory blood pressure monitorings (ABPM) obtained through an oscillometric upper-arm BP monitor allowing combined estimation of some vascular biomarkers. The present paper reports the results obtained in 1200 participants according to different categories of CV risk. Individual readings were averaged for each recording and 24-hour mean of brachial and aortic systolic (SBP) and diastolic blood pressure (DBP), pulse wave velocity (PWV), and augmentation index (AIx) obtained. Peripheral and central BP, PWV and AIx values were increased in older participants (SBP only) and in case of hypertension (SBP and DBP). BP was lower and PWV and AIx higher in females. PWV was increased and BP unchanged in case of metabolic syndrome. Our results suggest that ambulatory pulse wave analysis in a daily life setting may help evaluate vascular health of individuals at risk for CV disease.
Published: 2019

24. Ambulatory blood pressure and arterial stiffness web-based telemonitoring in patients at cardiovascular risk. First results of the VASOTENS (Vascular health ASsessment Of The hypertENSive patients) Registry

Author: Omboni S., Posokhov I., Parati G., Rogoza A., Kotovskaya Y., Arystan A., Avolio A., Barkan V., Bulanova N., Cardona Munoz E., Grigoricheva E., Konradi A., Minyukhina I., Muiesan M. L., Mule G., Orlova I., Pereira T., Peixoto Maldonado J. M., Statsenko M. E., Tilea I., Waisman G., Forcada P., Zelveian P., Butlin M., Barin E., Tan I., Ghiadoni L., Bruno R. M., Sarzani R., Espinosa E., Volpe M., Savoia C., Tocci G., Borghi C., Schillaci G., Pucci G., Paini A., Rizzoni D., Ramos C., Alanis A., Varga A., Volkov D., Kurlykina N., Rotar O., Orlov A., Gorbunov V., Boytsov S., Fedorova E., Korneva V., Kuznetsova T., Kulikova N., Evdokimov V. V., Kuznetsova A., Zheleznyak E., Kobalava Z., Borisova I., Svetozarsky T., Gubanova M., Lazareva V., Derevyanchenko M. V., Kopylov P., Sirenko Y., Recovets O., Borghi C, Omboni S., Posokhov I., Parati G., Rogoza A., Kotovskaya Y., Arystan A., Avolio A., Barkan V., Bulanova N., Cardona Munoz E., Grigoricheva E., Konradi A., Minyukhina I., Muiesan M.L., Mule G., Orlova I., Pereira T., Peixoto Maldonado J.M., Statsenko M.E., Tilea I., Waisman G., Forcada P., Zelveian P., Butlin M., Barin E., Tan I., Ghiadoni L., Bruno R.M., Sarzani R., Espinosa E., Volpe M., Savoia C., Tocci G., Borghi C., Schillaci G., Pucci G., Paini A., Rizzoni D., Ramos C., Alanis A., Varga A., Volkov D., Kurlykina N., Rotar O., Orlov A., Gorbunov V., Boytsov S., Fedorova E., Korneva V., Kuznetsova T., Kulikova N., Evdokimov V.V., Kuznetsova A., Zheleznyak E., Kobalava Z., Borisova I., Svetozarsky T., Gubanova M., Lazareva V., Derevyanchenko M.V., Kopylov P., Sirenko Y., Recovets O., Omboni, S, Posokhov, I, Parati, G, Rogoza, A, Kotovskaya, Y, Arystan, A, Avolio, A, Barkan, V, Bulanova, N, Cardona Munoz, E, Grigoricheva, E, Konradi, A, Minyukhina, I, Muiesan, M, Mule, G, Orlova, I, Pereira, T, Peixoto Maldonado, J, Statsenko, M, Tilea, I, Waisman, G, Forcada, P, Zelveian, P, Butlin, M, Barin, E, Tan, I, Ghiadoni, L, Bruno, R, Sarzani, R, Espinosa, E, Volpe, M, Savoia, C, Tocci, G, Borghi, C, Schillaci, G, Pucci, G, Paini, A, Rizzoni, D, Ramos, C, Alanis, A, Varga, A, Volkov, D, Kurlykina, N, Rotar, O, Orlov, A, Gorbunov, V, Boytsov, S, Fedorova, E, Korneva, V, Kuznetsova, T, Kulikova, N, Evdokimov, V, Kuznetsova, A, Zheleznyak, E, Kobalava, Z, Borisova, I, Svetozarsky, T, Gubanova, M, Lazareva, V, Derevyanchenko, M, Kopylov, P, Sirenko, Y, Recovets, O, and Borghi C
Subjects: Male, central aortic pressure, Non-Randomized Controlled Trials as Topic, Endocrinology, Diabetes and Metabolism, 030204 cardiovascular system & hematology, augmentation index, 0302 clinical medicine, arterial stiffness, blood pressure, blood pressure telemonitoring, hypertension, pulse wave velocity, vascular biomarkers, Diastole, Risk Factors, arterial stiffne, Prospective Studies, Registries, 030212 general & internal medicine, Pulse wave velocity, Aorta, Metabolic Syndrome, Blood Pressure Monitoring, Ambulatory, Middle Aged, Telemedicine, Cardiovascular Diseases, Ambulatory, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, Internet-Based Intervention, circulatory and respiratory physiology, Adult, medicine.medical_specialty, Ambulatory blood pressure, Systole, Pulse Wave Analysis, Vascular health, 03 medical and health sciences, Vascular Stiffness, Oscillometry, Internal medicine, Internal Medicine, medicine, Humans, Arterial Pressure, In patient, cardiovascular diseases, Aged, business.industry, medicine.disease, vascular biomarker, Cross-Sectional Studies, Blood pressure, Case-Control Studies, Arterial stiffness, Metabolic syndrome, business
Abstract: The VASOTENS Registry is an international telehealth-based repository of 24-hour ambulatory blood pressure monitorings (ABPM) obtained through an oscillometric upper-arm BP monitor allowing combined estimation of some vascular biomarkers. The present paper reports the results obtained in 1200 participants according to different categories of CV risk. Individual readings were averaged for each recording and 24-hour mean of brachial and aortic systolic (SBP) and diastolic blood pressure (DBP), pulse wave velocity (PWV), and augmentation index (AIx) obtained. Peripheral and central BP, PWVand AIx values were increased in older participants (SBP only) and in case of hypertension (SBP and DBP). BP was lower and PWVand AIx higher in females. PWV was increased and BP unchanged in case of metabolic syndrome. Our results suggest that ambulatory pulse wave analysis in a daily life setting may help evaluate vascular health of individuals at risk for CV disease.
Published: 2019

25. Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

Author: Scichilone, Nicola, Antonelli Incalzi, Raffaele, Blasi, Francesco, Schino, Pietro, Cuttitta, Giuseppina, Zullo, Alessandro, Ori, Alessandra, Canonica, Giorgio Walter, Schino P, Cuttitta G, Foschino MP, Prediletto R, Tranfa C, Zappa MC, Patriciello P, Labate L, Mariotta S, Nava S, Vatrella A, Mastroberardino M, Sarzani R, Iuliano A, Maggi L, Zedda A, Pesci A, Sera G, Nicolini A, Salvatore Walter DD, Forte S, Mario DD, Rivolta F, Ferliga M, Raco AF, Luigi DR, Cabibbo G, Maselli R, Gulotta C, Nardini S, Guffanti EE, Castellani W, Triolo L, Passalacqua G, Beghè B, Salvatore LC, Faccini E, Atzeni E, Tazza R, Giamesio P., Scichilone N., Antonelli Incalzi R., Blasi F., Schino P., Cuttitta G., Zullo A., Ori A., Canonica G., Foschino M.P., Prediletto R., Tranfa C.M.E., Zappa M.C., Patriciello P., Labate L., Mariotta S., Nava S., Vatrella A., Mastroberardino M., Sarzani R., Iuliano A., Maggi L., Zedda A., Pesci A., Sera G., Nicolini A., Salvatore Walter D.D., Forte S., Mario D.D., Rivolta F., Ferliga M., Raco A.F., Luigi D.R., Cabibbo G., Maselli R., Gulotta C., Nardini S., Guffanti E.E., Castellani W., Triolo L., Passalacqua G., Beghe B., Salvatore L.C., Faccini E., Atzeni E., Tazza R., Giamesio P., Scichilone, N, Antonelli Incalzi, R, Blasi, F, Schino, P, Cuttitta, G, Zullo, A, Ori, A, Canonica, G, Foschino, M, Prediletto, R, Tranfa, C, Zappa, M, Patriciello, P, Labate, L, Mariotta, S, Nava, S, Vatrella, A, Mastroberardino, M, Sarzani, R, Iuliano, A, Maggi, L, Zedda, A, Pesci, A, Sera, G, Nicolini, A, Salvatore Walter, D, Forte, S, Mario, D, Rivolta, F, Ferliga, M, Raco, A, Luigi, D, Cabibbo, G, Maselli, R, Gulotta, C, Nardini, S, Guffanti, E, Castellani, W, Triolo, L, Passalacqua, G, Beghe, B, Salvatore, L, Faccini, E, Atzeni, E, Tazza, R, Giamesio, P, Scichilone, Nicola, Antonelli Incalzi, Raffaele, Blasi, Francesco, Schino, Pietro, Cuttitta, Giuseppina, Zullo, Alessandro, Ori, Alessandra, Canonica, Giorgio, Walter, Foschino, Mp, Zappa, Mc, Salvatore Walter, Dd, Mario, Dd, Raco, Af, Luigi, Dr, Guffanti, Ee, Beghè, B, Salvatore, Lc, and Giamesio, P.
Subjects: Male, Chronic bronchitis, Time Factors, Health Status, Anxiety, Hospital Anxiety and Depression Scale, Severity of Illness Index, Health Statu, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Surveys and Questionnaires, Forced Expiratory Volume, Clinical phenotype, Medicine, Surveys and Questionnaire, Respiratory function, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Lung, Depression (differential diagnoses), COPD, Depression, Middle Aged, Circadian Rhythm, Phenotype, Italy, Female, medicine.symptom, 24-hour symptoms, Clinical phenotype, Real-world, Respiratory function, Research Article, Human, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Chronic Obstructive, Time Factor, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Pulmonary Disease, 03 medical and health sciences, Internal medicine, Humans, Asthma, 24-hour symptoms, Real-world, Aged, Sleep, Quality of Life, lcsh:RC705-779, business.industry, Correction, lcsh:Diseases of the respiratory system, medicine.disease, 24-hour symptom, Prospective Studie, 030228 respiratory system, business
Abstract: Background Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline early-morning, day-time and nocturnal symptoms (gathered via the Night-time, Morning and Day-time Symptoms of COPD questionnaire), HR-QoL (via the St. George’s Respiratory Questionnaire), anxiety and depression levels (via the Hospital Anxiety and Depression Scale), quality of sleep (via COPD and Asthma Sleep Impact Scale), physical activity (via the International Physical Activity Questionnaire) as well as lung function were recorded. Results 606 COPD subjects (age 71.4 ± 8.2 years, male 75.1%) were studied. 57.9, 35.5 5.3 and 1.3% of the sample belonged to the CB, EM, MCA and EM + CB phenotypes respectively. The vast majority of subjects reported early-morning and day-time symptoms (79.5 and 79.2% in the CB and 75.8 and 77.7% in the EM groups); the proportion suffering from night-time symptoms was higher in the CB than in the EM group (53.6% vs. 39.5%, p = 0.0016). In both CB and EM, indiscriminately, the presence of symptoms during the 24-h day was associated with poorer HR-QoL, worse quality of sleep and higher levels of anxiety/depression. Conclusions The findings highlight the primary classificatory role of nocturnal symptoms in COPD. Trial registration Trial registration number: NCT03105999, date of registration: 10th April 2017.
Published: 2019

26. Covid-19 and the role of smoking. The protocol of the multicentric prospective study COSMO-IT (COvid19 and SMOking in ITaly)

Author: Cattaruzza, M. S., Gorini, G., Bosetti, C., Boffi, R., Lugo, A., Veronese, C., Carreras, G., Santucci, C., Stival, C., Pacifici, R., Zaga, V., Gallus, S., Giulietti, F., Sarzani, R., Spannella, F., Del Donno, M., Tartaglione, S., Marrazzo, G., Pelaia, G., D'Agosto, V., Berti, A., Voller, F., Cardellicchio, S., Cresci, C., Foschino Barbaro, M. P., De Palma, R., Negrini, S., Sicbaldi, V., Serafini, A., Bisconti, M., Refolo, L., Landoni, G., Rovere, P., Veronesi, G., Faverio, P., Garavello, W., Pesci, A., Giacobbe, R., Martucci, P., Parrella, R., Scarano, F., Aiello, M., Chetta, A., Franco, C., Mangia, A., Carrozzi, L., Maggi, F., Monzani, F., Pistelli, F., Russo, P., Sanna, A., Barreca, F. M., Conti, V., Rossi, E., Ruli, M., Ruli, S., Varzaneh, S. E., Principe, R., Guerrini, S., Sebastiani, A., Galluccio, G., Pezzuto, A., Ricci, A., Casali, E., Mastroianni, C., Pirina, P., Polo, F., Beatrice, F., Romagnoli, M., Baraldo, M., Cojutti, P. G., Graziano, E., Pecori, D., Tascini, C., Tinghino, B., Cattaruzza, Maria Sofia, Gorini, Giuseppe, Bosetti, Cristina, Boffi, Roberto, Lugo, Alessandra, Veronese, Chiara, Carreras, Giulia, Santucci, Claudia, Stival, Chiara, Pacifici, Roberta, Zagà, Vincenzo, Gallus, Silvano, Giulietti, Federico, Sarzani, Riccardo, Spannella, Francesco, Del Donno, Mario, Tartaglione, Stefania, Marrazzo, Giuseppina, Pelaia, Girolamo, D'Agosto, Vincenzo, Berti, Alice, Voller, Fabio, Cardellicchio, Salvatore, Cresci, Chiara, Foschino Barbaro, Maria Pia, De Palma, Raffaele, Negrini, Simone, Sicbaldi, Vera, Serafini, Antonella, Bisconti, Mario, Refolo, Leonida, Landoni, Giovanni, Rovere, Patrizia, Veronesi, Giulia, Faverio, Paola, Garavello, Werner, Pesci, Alberto, Giacobbe, Raffaella, Martucci, Paola, Parrella, Roberto, Scarano, Francesco, Aiello, Marina, Chetta, Alfredo, Franco, Cosimo, Mangia, Angelo, Carrozzi, Laura, Maggi, Fabrizio, Monzani, Fabio, Pistelli, Francesco, Russo, Patrizia, Sanna, Antonio, Barreca, Filippo Maria, Conti, Valentina, Rossi, Enrico, Ruli, Mei, Ruli, Silvana, Eslami Varzaneh, Shokoofe, Principe, Rosastella, Guerrini, Simone, Sebastiani, Alfredo, Galluccio, Giovanni, Pezzuto, Aldo, Ricci, Alberto, Casali, Elena, Mastroianni, Claudio, Pirina, Pietro, Polo, Francesca, Beatrice, Fabio, Romagnoli, Micaela, Baraldo, Massimo, Cojutti, Pier Giorgio, Tascini, Carlo, Pecori, Davide, Graziano, Elena, Tinghino, Biagio, Cattaruzza, M, Gorini, G, Bosetti, C, Boffi, R, Lugo, A, Veronese, C, Carreras, G, Santucci, C, Stival, C, Pacifici, R, Zaga, V, Gallus, S, Giulietti, F, Sarzani, R, Spannella, F, Del Donno, M, Tartaglione, S, Marrazzo, G, Pelaia, G, D'Agosto, V, Berti, A, Voller, F, Cardellicchio, S, Cresci, C, Foschino Barbaro, M, De Palma, R, Negrini, S, Sicbaldi, V, Serafini, A, Bisconti, M, Refolo, L, Landoni, G, Rovere, P, Veronesi, G, Faverio, P, Garavello, W, Pesci, A, Giacobbe, R, Martucci, P, Parrella, R, Scarano, F, Aiello, M, Chetta, A, Franco, C, Mangia, A, Carrozzi, L, Maggi Monzani, F, Pistelli, F, Russo, P, Sanna, A, Barreca, F, Conti, V, Rossi, E, Ruli, M, Ruli, S, Varzaneh, S, Principe, R, Guerrini, S, Sebastiani, A, Galluccio, G, Pezzuto, A, Ricci, A, Casali, E, Mastroianni, C, Pirina, P, Polo, F, Beatrice, F, Romagnoli, M, Baraldo, M, Cojutti, P, Graziano, E, Pecori, D, Tascini, C, and Tinghino, B
Subjects: Male, Prognosi, Pneumonia, Viral, Lifestyle habit, COVID-19, Lifestyle habits, Prognosis, Risk factors, SARS-COV-2, Smoking, Tobacco, tobacco, smoking, Follow-Up Studie, Betacoronavirus, lifstyle habits, prognosis, tobacco, risk factors, Prevalence, Tobacco Smoking, Humans, risk factors, Viral, Prospective Studies, Life Style, Pandemics, lifestyle habits, Betacoronaviru, Pandemic, Coronavirus Infection, SARS-CoV-2, Pneumonia, Coronavirus Infections, Female, Follow-Up Studies, Italy, covid-19, sars-cov-2, Original Investigations / Commentaries, Prospective Studie, Risk factor, Human
Abstract: The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT). About 30 Italian hospitals in North, Centre and South of Italy joined the study. Its main aims are: 1) to quantify the role of tobacco smoking and smoking cessation on the severity and progression of COVID-19 in hospitalized patients; 2) to compare smoking prevalence and severity of the disease in relation to smoking in hospitalized COVID-19 patients versus patients treated at home; 3) to quantify the association between other lifestyle factors, such as e-cigarette and HTP use, alcohol and obesity and the risk of unfavourable COVID-19 outcomes. Socio-demographic, lifestyle and medical history information will be gathered for around 3000 hospitalized and 700-1000 home-isolated, laboratory-confirmed, COVID-19 patients. Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for -COVID-19, prevention strategies are of extreme importance. This project, designed to highly contribute to the international scientific debate on the role of avoidable lifestyle habits on COVID-19 severity, will provide valuable epidemiological data in order to support important recommendations to prevent COVID-19 incidence, progression and mortality.
Published: 2020

27. The calculation of LDL-cholesterol: Comparison of traditional and recent equations and their impact on lipid control rates in a hypertensive population at variable cardiovascular risk

Author: Sarzani, R., primary, Giulietti, F., additional, Allevi, M., additional, Biondini, S., additional, Garbuglia, C., additional, and Spannella, F., additional
Published: 2021
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28. Erratum: Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARSRAS study of the Italian Society of Hypertension (PLoS ONE (2020) 15:10 (e0237297) DOI: 10.1371/journal.pone.0237297)

Author: Iaccarino, G., Grassi, G., Borghi, C., Carugo, S., Fallo, F., Ferri, C., Giannattasio, C., Grassi, D., Letizia, C., Mancusi, C., Minuz, P., Perlini, S., Pucci, G., Rizzoni, D., Salvetti, M., Sarzani, R., Sechi, L., Veglio, F., Volpe, M., and Muiesan, M. L.
Published: 2021

29. Determinants of healing among patients with COVID-19: The results of the SARS-RAS study of the Italian Society of Hypertension

Author: Mancusi, C., Grassi, G., Borghi, C., Carugo, S., Fallo, F., Ferri, C., Giannattasio, C., Grassi, D., Letizia, C., Minuz, P., Muiesan, M. L., Perlini, S., Pucci, G., Rizzoni, D., Salvetti, M., Sarzani, R., Sechi, L., Veglio, F., Volpe, M., and Iaccarino, G.
Subjects: Adult, Male, Chronic conditions, Adolescent, Angiotensin-Converting Enzyme Inhibitors, Outcomes, Comorbidity, Renin-Angiotensin System, Angiotensin Receptor Antagonists, Young Adult, Coronavirus disease 2019, Multimorbidity, Recovery, Age Factors, Aged, Aged, 80 and over, Analysis of Variance, Antihypertensive Agents, COVID-19, Chronic Disease, Cross-Sectional Studies, Female, Heart Failure, Hospitalization, Humans, Hypertension, Italy, Middle Aged, Renal Insufficiency, Chronic, SARS-CoV-2, Surveys and Questionnaires, 80 and over, Renal Insufficiency, Chronic
Published: 2021

30. Correction: Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension

Author: Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, Iaccarino, Guido, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Mancusi, Costantino, Minuz, Pietro, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, Muiesan, Maria Lorenza, Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, Iaccarino, Guido, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Mancusi, Costantino, Minuz, Pietro, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, and Muiesan, Maria Lorenza
Abstract: [This corrects the article DOI: 10.1371/journal.pone.0237297.].
Published: 2021

31. Erratum: Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARSRAS study of the Italian Society of Hypertension (PLoS ONE (2020) 15:10 (e0237297) DOI: 10.1371/journal.pone.0237297)

Author: Iaccarino, Guido, Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, Iaccarino, Guido, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Mancusi, Costantino, Minuz, Pietro, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, Muiesan, Maria Lorenza, Iaccarino, Guido, Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, Iaccarino, Guido, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Mancusi, Costantino, Minuz, Pietro, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, and Muiesan, Maria Lorenza
Published: 2021

32. Determinants of healing among patients with coronavirus disease 2019: the results of the SARS-RAS study of the Italian Society of Hypertension

Author: Mancusi, C, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Minuz, P, Muiesan, M, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Iaccarino, G, Mancusi, Costantino, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Minuz, Pietro, Muiesan, Maria Lorenza, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, Iaccarino, Guido, Mancusi, C, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Minuz, P, Muiesan, M, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Iaccarino, G, Mancusi, Costantino, Grassi, Guido, Borghi, Claudio, Carugo, Stefano, Fallo, Francesco, Ferri, Claudio, Giannattasio, Cristina, Grassi, Davide, Letizia, Claudio, Minuz, Pietro, Muiesan, Maria Lorenza, Perlini, Stefano, Pucci, Giacomo, Rizzoni, Damiano, Salvetti, Massimo, Sarzani, Riccardo, Sechi, Leonardo, Veglio, Franco, Volpe, Massimo, and Iaccarino, Guido
Abstract: OBJECTIVE: The burst of COVID-19 epidemics in Italy prompted the Italian Society of Hypertension to start an observational study to explore the characteristics of the hospitalized victims of the disease. The current analysis aimed to investigate the predictors of healing among Italian COVID-19 patients. We also assessed the effect of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers on the outcome. METHODS: We designed a cross-sectional, observational, multicenter, nationwide survey in Italy to explore the demographic and clinical characteristics of patients with confirmed COVID-19 infection. We analyzed information from 2446 charts of Italian patients admitted for certified COVID-19 in 27 hospitals. Healing from COVID-19 infection, defined as two consecutive negative swabs, was reported in 544 patients (22.2%), 95% of them were hospitalized. RESULTS: Age and Charlson Comorbidity Index were significantly lower in healing compared with nonhealing patients (63 ± 15 vs. 69 ± 15 and 2 ± 2 vs. 3 ± 2, both P < 0.05). In multivariable regression model, predictors of healing were younger age (OR: 0.99; 95% CI 0.98-0.99, P = 0.0001), absence of chronic kidney disease (OR: 0.35; 95% CI 0.17-0.70, P = 0.003) or heart failure (OR: 0.44; 95% CI, 0.28-0.70, P = 0.001). In the subgroup of patients suffering from hypertension and/or heart failure (n = 1498), no differences were observed in the use of ACE inhibitors and angiotensin receptor blockers. CONCLUSION: Our study demonstrated that younger age and absence of comorbidities play a major role in determining healing in patients with COVID-19. No effects of ACE inhibitors and angiotensin receptor blockers on the outcome was reported.
Published: 2021

33. Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue

Author: Sarzani, R, Bordicchia, M, Marcucci, P, Minardi, D, Muzzonigro, G, Dessì-Fulgheri, P, and Rappelli, A
Published: 2010
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34. Validation of an easy questionnaire on the assessment of salt habit: the MINISAL-SIIA Study Program

Author: D’Elia, L., Manfredi, M., Strazzullo, P., Galletti, F., Agabiti-Rosei, E., Arcangeli, E., Artom, A., Barbato, A., Barbiero, M., Belfiore, A., Bernini, G., Boero, R., Berra, E., Biggi, A., Borgheresi, P., Borghi, C., Bosio, A., Caiazza, A., Caielli, P., Caló, L. A., Castellano, M., Catena, C., Cerrato, F., Cilia, C., Cipollini, F., Crippa, M., Cuspidi, C., D’Avino, M., De Giorgi, G. A., De Luca, N., De Pergola, G., Del Giudice, A., Desideri, G., Fallo, F., Ferri, C., Galeone, D., Garavelli, G., Gaudio, G., Giacchetti, G., Gidaro, B., Giovannetti, R., Grandi, A., Guglielmi, M., Iacoviello, L., Leonardis, D., Lonati, C., Lonati, L. M., Malatino, L., Mallamaci, F., Maresca, A. M., Marzano, L., Massara, C., Merletti, L., Meschi, M., Modesti, S., Montanari, A., Morganti, A., Musiari, L., Musso, N., Nardecchia, A., Nazzaro, P., Pallisco, O., Panichi, V., Parati, G., Pascale, C., Pini, C., Pirola, I., Pucci, G., Rabbia, F., Rescaldani, M., Ronchi, E., Rossi, E., Rossi, G., Sala, C., Sarzani, R., Sechi, L. A., Silvestris, F., Stancanelli, B., Trimarco, B., Ungar, A., Veglio, F., Veronesi, M., Vinella, L., D'Elia, L, Manfredi, M, Strazzullo, P, Galletti, F, Agabiti-Rosei, E, Arcangeli, E, Artom, A, Barbato, A, Barbiero, M, Belfiore, A, Bernini, G, Boero, R, Berra, E, Biggi, A, Borgheresi, P, Borghi, C, Bosio, A, Caiazza, A, Caielli, P, Calo, L, Castellano, M, Catena, C, Cerrato, F, Cilia, C, Cipollini, F, Crippa, M, Cuspidi, C, D'Avino, M, De Giorgi, G, De Luca, N, De Pergola, G, Del Giudice, A, Desideri, G, Fallo, F, Ferri, C, Galeone, D, Garavelli, G, Gaudio, G, Giacchetti, G, Gidaro, B, Giovannetti, R, Grandi, A, Guglielmi, M, Iacoviello, L, Leonardis, D, Lonati, C, Lonati, L, Malatino, L, Mallamaci, F, Maresca, A, Marzano, L, Massara, C, Merletti, L, Meschi, M, Modesti, S, Montanari, A, Morganti, A, Musiari, L, Musso, N, Nardecchia, A, Nazzaro, P, Pallisco, O, Panichi, V, Parati, G, Pascale, C, Pini, C, Pirola, I, Pucci, G, Rabbia, F, Rescaldani, M, Ronchi, E, Rossi, E, Rossi, G, Sala, C, Sarzani, R, Sechi, L, Silvestris, F, Stancanelli, B, Trimarco, B, Ungar, A, Veglio, F, Veronesi, M, Vinella, L, L. D’Elia, M. Manfredi, P. Strazzullo, F. Galletti, E. Agabiti-Rosei, E. Arcangeli, A. Artom, A. Barbato, M. Barbiero, A. Belfiore, G. Bernini, R. Boero, E. Berra, A. Biggi, P. Borgheresi, C. Borghi, A. Bosio, A. Caiazza, P. Caielli, L. A. Caló, M. Castellano, C. Catena, F. Cerrato, C. Cilia, F. Cipollini, M. Crippa, C. Cuspidi, M. D’Avino, G. A. De Giorgi, N. De Luca, G. De Pergola, A. Del Giudice, G. Desideri, F. Fallo, C. Ferri, D. Galeone, G. Garavelli, G. Gaudio, G. Giacchetti, B. Gidaro, R. Giovannetti, A. Grandi, M. Guglielmi, L. Iacoviello, D. Leonardi, C. Lonati, L. M. Lonati, L. Malatino, F. Mallamaci, A. M. Maresca, L. Marzano, C. Massara, L. Merletti, M. Meschi, S. Modesti, A. Montanari, A. Morganti, L. Musiari, N. Musso, A. Nardecchia, P. Nazzaro, O. Pallisco, V. Panichi, G. Parati, C. Pascale, C. Pini, I. Pirola, G. Pucci, F. Rabbia, M. Rescaldani, E. Ronchi, E. Rossi, G. Rossi, C. Sala, R. Sarzani, L. A. Sechi, F. Silvestri, B. Stancanelli, B. Trimarco, A. Ungar, F. Veglio, M. Veronesi, and L. Vinella
Subjects: Male, 0301 basic medicine, Validation study, medicine.medical_specialty, media_common.quotation_subject, Medicine (miscellaneous), 030209 endocrinology & metabolism, Nutrition and Dietetic, hypertension, sodium intake, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Internal medicine, Nutrition and Dietetic, medicine, Humans, MINISAL-SIIA, Sodium Chloride, Dietary, Nutrition, media_common, 030109 nutrition & dietetics, Nutrition and Dietetics, Urinary sodium, business.industry, MINISAL-SIIA Study Program, Reproducibility of Results, Middle Aged, Anthropometry, Blood pressure, Italy, Hypertension, Dietary salt intake, Female, Habit, dietary salt intake, business, Dietetic, sodium intake
Abstract: Background/objectives: The aim of the present study was to validate a short questionnaire on habitual dietary salt intake, to quickly and easily identify individuals whose salt consumption exceeds recommended levels. Subjects/methods: A total of 1131 hypertensive subjects participating in the MINISAL-SIIA study were included in the analysis. Anthropometric indexes, blood pressure, and 24-h urinary sodium excretion (NaU) were measured. A fixed-sequence questionnaire on dietary salt intake was administered. Results: NaU was significantly associated with scores, with a linear association across categories (p for trend 85 mmol/day) and “very high NaU” (NaU > 170 mmol/day) was 86 and 35%, respectively. The score of the questionnaire had a significant ability to detect both “high NaU”—with a specificity of 95% at the score of 10 points—and “very high NaU”—with a specificity of 99.6% at score of 13 points. Conclusions: The main results of the study indicates that a higher score of this short questionnaire is distinctive of habitual high salt consumption in hypertensive patients.
Published: 2019

35. Expression of potassium channel isoforms mRNA in normal human adrenals and aldosterone-secreting adenomas

Author: Sarzani, R., Pietrucci, F., Francioni, M., Salvi, F., Letizia, C., D’Erasmo, E., Dessì Fulgheri, P., and Rappelli, A.
Published: 2006
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36. May Measurement Month 2018: an analysis of blood pressure screening results from Italy

Author: Torlasco, C, Faini, A, Ferri, C, Grassi, G, Salvetti, M, Destro, M, Cicero, A, Galletti, F, Ghiadoni, L, Carugo, S, Sarzani, R, Minuz, P, Morganti, A, Mulatero, P, Mulè, G, Savoia, C, Volpe, M, Borghi, C, Beaney, T, Ster, A, Poulter, N, Xia, X, Parati, G, Torlasco, Camilla, Faini, Andrea, Ferri, Claudio, Grassi, Guido, Salvetti, Massimo, Destro, Maurizio, Cicero, Arrigo F G, Galletti, Ferruccio, Ghiadoni, Lorenzo, Carugo, Stefano, Sarzani, Riccardo, Minuz, Pietro, Morganti, Alberto, Mulatero, Paolo, Mulè, Giuseppe, Savoia, Carmine, Volpe, Massimo, Borghi, Claudio, Beaney, Thomas, Ster, Anca Chis, Poulter, Neil R, Xia, Xin, Parati, Gianfranco, Torlasco, C, Faini, A, Ferri, C, Grassi, G, Salvetti, M, Destro, M, Cicero, A, Galletti, F, Ghiadoni, L, Carugo, S, Sarzani, R, Minuz, P, Morganti, A, Mulatero, P, Mulè, G, Savoia, C, Volpe, M, Borghi, C, Beaney, T, Ster, A, Poulter, N, Xia, X, Parati, G, Torlasco, Camilla, Faini, Andrea, Ferri, Claudio, Grassi, Guido, Salvetti, Massimo, Destro, Maurizio, Cicero, Arrigo F G, Galletti, Ferruccio, Ghiadoni, Lorenzo, Carugo, Stefano, Sarzani, Riccardo, Minuz, Pietro, Morganti, Alberto, Mulatero, Paolo, Mulè, Giuseppe, Savoia, Carmine, Volpe, Massimo, Borghi, Claudio, Beaney, Thomas, Ster, Anca Chis, Poulter, Neil R, Xia, Xin, and Parati, Gianfranco
Abstract: Cardiovascular (CV) diseases are burdened by high mortality and morbidity, being responsible for half of the deaths in Europe. Although hypertension is recognized as the most important CV risk factor, hypertension awareness and blood pressure (BP) control are still unsatisfactory. In 2017, 30.6% of a >10 000 individual sample who took part in the May Measurement Month (MMM) campaign in Italy was found to have high BP. To raise awareness on the hypertension issue and to report BP data on a nation-wide scale in Italy. In the frame of the MMM campaign, an opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in May 2018. Blood pressure measurement, the definition of hypertension and statistical analysis followed the standard MMM protocol. Screenings were conducted in multiple sites by health care personnel. Among the 5554 people screened (females: 48.3%, mean age 58 ± 17 years) mean BP was 127/77 mmHg, and after imputations, 1462 (26.3%) participants were found to have high BP levels. Body mass index >25 was associated with higher systolic BP and diastolic BP (DBP), while diabetes was associated with high DBP only. Our data provide a nation-wide snapshot of BP control in a sample of individuals participating in a national health care campaign, and confirm the power of this kind of healthcare-related activities in reaching a significant number of people to raise awareness on health topics. The apparent positive trend in BP control compared to available data from other similar campaigns carried out during the past years needs to be confirmed with more methodologically robust studies.
Published: 2020

37. Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the italian society of hypertension

Author: Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, Muiesan, ML, Iaccarino, G, Grassi, G, Borghi, C, Carugo, S, Fallo, F, Ferri, C, Giannattasio, C, Grassi, D, Letizia, C, Mancusi, C, Minuz, P, Perlini, S, Pucci, G, Rizzoni, D, Salvetti, M, Sarzani, R, Sechi, L, Veglio, F, Volpe, M, Muiesan, M, and Muiesan, ML
Abstract: The global rate of intensive care unit (ICU) admission during the COVID-19 pandemic varies within countries and is among the main challenges for health care systems worldwide. Conflicting results have been reported about the response to coronavirus infection and COVID-19 outcomes in men and women. Understanding predictors of intensive care unit admission might be of help for future planning and management of the disease. Methods and findings We designed a cross-sectional observational multicenter nationwide survey in Italy to understand gender-related clinical predictors of ICU admission in patients with COVID-19. We analyzed information from 2378 charts of Italian patients certified for COVID-19 admitted in 26 hospitals. Three hundred ninety-five patients (16.6%) required ICU admission due to COVID19 infection, more frequently men (74%), with a higher prevalence of comorbidities (1,78±0,06 vs 1,54±0,03 p<0.05). In multivariable regression model main predictors of admission to ICU are male gender (OR 1,74 95% CI 1,36–2,22 p<0.0001) and presence of obesity (OR 2,88 95% CI 2,03–4,07 p<0.0001), chronic kidney disease (OR: 1,588; 95%, 1,036–2,434 p<0,05) and hypertension (OR: 1,314; 95% 1,039–1,662; p<0,05). In gender specific analysis, obesity, chronic kidney disease and hypertension are associated with higher rate of admission to ICU among men, whereas in women, obesity (OR: 2,564; 95% CI 1,336–4.920 p<0.0001) and heart failure (OR: 1,775 95% CI: 1,030–3,057) are associated with higher rate of ICU admission. Conclusions Our study demonstrates that gender is the primary determinant of the disease’s severity among COVID-19. Obesity is the condition more often observed among those admitted to ICU within both genders.
Published: 2020

38. Cardiovascular effects of sildenafil in hypertensive men with erectile dysfunction and different alleles of the type 5 cGMP-specific phosphodiesterase (PDE5)

Author: Salvi, F, Sarzani, R, Giorgi, R, Donatelli, G, Pietrucci, F, Micheli, A, Baldoni, M, Minaroli, D, Dessì-Fulgheri, P, Polito, M, Muzzonigro, G, and Rappelli, A
Published: 2004
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39. Natriuretic peptide system and cardiovascular risk: Higher natriuretic peptides levels is associated with a favorable lipid profile

Author: Spannella, F., primary, Di Pentima, C., additional, Giulietti, F., additional, and Sarzani, R., additional
Published: 2020
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40. Control of cardiovascular risk factors according to score system in hypertensive patients: ESC/EAS 2016 and 2019 dyslipidemia guidelines comparison

Author: Sarzani, R., primary, Falzetti, S., additional, Giulietti, F., additional, Di Pentima, C., additional, Ristori, L., additional, Buscarini, S., additional, and Spannella, F., additional
Published: 2020
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41. Aldosterone synthase alleles and cardiovascular phenotype in young adults

Author: Sarzani, R, Salvi, F, Dessì-Fulgheri, P, Catalini, R, Mazzara, D, Cola, G, Siragusa, N, Spagnolo, D, Ercolani, P, Gesuita, R, Carle, F, and Rappelli, A
Published: 2003
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42. TCF7L2 alleles and metabolic syndrome in non-diabetic obese hypertensive patients

Author: Sarzani, R, Salvi, F, Bordicchia, M, Pietrucci, F, Caraceni, D, Lancioni, L, Dessí-Fulgheri, P, and Rappelli, A
Published: 2008
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43. Endocannabinoids, Blood Pressure and the Human Heart

Author: Sarzani, R.
Published: 2008

44. Angiotensin II stimulates and atrial natriuretic peptide inhibits human visceral adipocyte growth

Author: Sarzani, R, Marcucci, P, Salvi, F, Bordicchia, M, Espinosa, E, Mucci, L, Lorenzetti, B, Minardi, D, Muzzonigro, G, Dessì-Fulgheri, P, and Rappelli, A
Published: 2008
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45. “Double-Trouble” Atherogenic Lipid Profile In Overweight/Obese Hypertensive Patients Phenotyped By 24-Hour Ambulatory Blood Pressure Monitoring

Author: Spannella, F., primary, Giulietti, F., additional, Di Pentima, C., additional, Ristori, L., additional, Biondini, S., additional, and Sarzani, R., additional
Published: 2019
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46. OVERWEIGHT/OBESE HYPERTENSIVES EVALUATED BY 24-HOUR AMBULATORY BLOOD PRESSURE MONITORING HAVE A “DOUBLE-TROUBLE” ATHEROGENIC LIPID PROFILE

Author: Spannella, F., primary, Giulietti, F., additional, Di Pentima, C., additional, Filipponi, A., additional, Bernardi, B., additional, Buscarini, S., additional, and Sarzani, R., additional
Published: 2019
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47. Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

Author: Casula, M., Olmastroni, E., Pirillo, A., Catapano, A. L., Averna, M., Bertolini, Stefania, Calandra, S., Tarugi, P., Pellegatta, F., Angelico, F., Bartuli, A., Biasucci, G., Biolo, G., Bonanni, L., Bonomo, K., Borghi, C., Bossi, A. C., Branchi, A., Carubbi, F., Cipollone, F., Citroni, N., Federici, Marco, Ferri, C., Fiorenza, A. M., Giaccari, Andrea, Giorgino, F., Guardamagna, O., Iannuzzi, A., Iughetti, L., Lupattelli, G., Lupi, Alessandro, Mandraffino, G., Marcucci, R., Maroni, L., Miccoli, R., Mombelli, Gaia, Muntoni, S., Pecchioli, V., Pederiva, C., Pipolo, A., Pisciotta, L., Pujia, A., Purrello, F., Repetti, E., Rubba, P., Sabba, C., Sampietro, T., Sarzani, R., Tagliabue, M. P., Trenti, C., Vigna, G. B., Werba, J. P., Zambon, S., Zenti, M. G., Minicocci, I., Noto, D., Fortunato, G., Banderali, G., Benso, A., Bigolin, P., Bonora, E., Bruzzi, P., Bucci, M., Buonuomo, Paola Sabrina, Capra, M. E., Cardolini, I., Cefalu, B., Cervelli, N., Chiariello, Giovanni Alfonso, Cocci, G., Colombo, E., Cremonini, A. L., D'Addato, S., D'Erasmo, L., Dal Pino, B., De Sanctis, L., De Vita, E., Del Ben, M., Di Costanzo, A., Di Taranto, M. D., Fasano, T., Gentile, L., Gentile, Marino, Ghirardello, O., Grigore, L., Lussu, M., Meregalli, G., Moffa, Simona, Montalcini, T., Morgia, V., Nascimbeni, F., Pasta, A., Pavanello, C., Saitta, A., Scicali, R., Siepi, D., Spagnolli, W., Spina, R., Sticchi, E., Suppressa, P., Vigo, L., Vinci, P., Manzato, E., Tragni, E., Zampoleri, V., Arca, M., Bertolini S., Federici M., Giaccari A. (ORCID:0000-0002-7462-7792), Lupi A., Mombelli G., Buonuomo P. S., Chiariello G., Gentile M., Moffa S., Casula, M., Olmastroni, E., Pirillo, A., Catapano, A. L., Averna, M., Bertolini, Stefania, Calandra, S., Tarugi, P., Pellegatta, F., Angelico, F., Bartuli, A., Biasucci, G., Biolo, G., Bonanni, L., Bonomo, K., Borghi, C., Bossi, A. C., Branchi, A., Carubbi, F., Cipollone, F., Citroni, N., Federici, Marco, Ferri, C., Fiorenza, A. M., Giaccari, Andrea, Giorgino, F., Guardamagna, O., Iannuzzi, A., Iughetti, L., Lupattelli, G., Lupi, Alessandro, Mandraffino, G., Marcucci, R., Maroni, L., Miccoli, R., Mombelli, Gaia, Muntoni, S., Pecchioli, V., Pederiva, C., Pipolo, A., Pisciotta, L., Pujia, A., Purrello, F., Repetti, E., Rubba, P., Sabba, C., Sampietro, T., Sarzani, R., Tagliabue, M. P., Trenti, C., Vigna, G. B., Werba, J. P., Zambon, S., Zenti, M. G., Minicocci, I., Noto, D., Fortunato, G., Banderali, G., Benso, A., Bigolin, P., Bonora, E., Bruzzi, P., Bucci, M., Buonuomo, Paola Sabrina, Capra, M. E., Cardolini, I., Cefalu, B., Cervelli, N., Chiariello, Giovanni Alfonso, Cocci, G., Colombo, E., Cremonini, A. L., D'Addato, S., D'Erasmo, L., Dal Pino, B., De Sanctis, L., De Vita, E., Del Ben, M., Di Costanzo, A., Di Taranto, M. D., Fasano, T., Gentile, L., Gentile, Marino, Ghirardello, O., Grigore, L., Lussu, M., Meregalli, G., Moffa, Simona, Montalcini, T., Morgia, V., Nascimbeni, F., Pasta, A., Pavanello, C., Saitta, A., Scicali, R., Siepi, D., Spagnolli, W., Spina, R., Sticchi, E., Suppressa, P., Vigo, L., Vinci, P., Manzato, E., Tragni, E., Zampoleri, V., Arca, M., Bertolini S., Federici M., Giaccari A. (ORCID:0000-0002-7462-7792), Lupi A., Mombelli G., Buonuomo P. S., Chiariello G., Gentile M., and Moffa S.
Abstract: Background and aims: Familial hypercholesterolemia (FH) is an inherited disorder characterized by high levels of blood cholesterol from birth and premature coronary heart disease. Thus, the identification of FH patients is crucial to prevent or delay the onset of cardiovascular events, and the availability of a tool helping with the diagnosis in the setting of general medicine is essential to improve FH patient identification. Methods: This study evaluated the performance of the Dutch Lipid Clinic Network (DLCN) score in FH patients enrolled in the LIPIGEN study, an Italian integrated network aimed at improving the identification of patients with genetic dyslipidaemias, including FH. Results: The DLCN score was applied on a sample of 1377 adults (mean age 42.9 ± 14.2 years) with genetic diagnosis of FH, resulting in 28.5% of the sample classified as probable FH and 37.9% as classified definite FH. Among these subjects, 43.4% had at least one missing data out of 8, and about 10.0% had 4 missing data or more. When analyzed based on the type of missing data, a higher percentage of subjects with at least 1 missing data in the clinical history or physical examination was classified as possible FH (DLCN score 3–5). We also found that using real or estimated pre-treatment LDL-C levels may significantly modify the DLCN score. Conclusions: Although the DLCN score is a useful tool for physicians in the diagnosis of FH, it may be limited by the complexity to retrieve all the essential information, suggesting a crucial role of the clinical judgement in the identification of FH subjects.
Published: 2018

48. CIRCULATING LOW-DENSITY LIPOPROTEIN CHOLESTEROL IS INVERSELY CORRELATED WITH N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE IN VERY ELDERLY HOSPITALIZED PATIENTS

Author: Spannella, F., primary, Cocci, G., additional, Giulietti, F., additional, Landi, L., additional, Rosettani, G., additional, Bordoni, V., additional, Giordano, P., additional, and Sarzani, R., additional
Published: 2018
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49. N-terminal pro B-Type natriuretic peptide is inversely correlated with low density lipoprotein cholesterol in the very elderly

Author: Spannella, F., primary, Giulietti, F., additional, Cocci, G., additional, Landi, L., additional, Borioni, E., additional, Lombardi, F.E., additional, Rosettani, G., additional, Bernardi, B., additional, Bordoni, V., additional, Giordano, P., additional, Bordicchia, M., additional, and Sarzani, R., additional
Published: 2018
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50. CHANGES IN BLOOD PRESSURE AND METABOLIC PARAMETERS IN OVERWEIGHT PATIENTS WITH OBSTRUCTIVE SLEEP APNOEA SYNDROME AFTER 3-MONTH CONTINUOUS POSITIVE AIRWAY PRESSURE THERAPY

Author: Spannella, F., primary, Giulietti, F., additional, Di Pentima, C., additional, Borioni, E., additional, Lombardi, F.E., additional, Cocci, G., additional, Bernardi, B., additional, Iacoacci, C., additional, and Sarzani, R., additional
Published: 2018
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