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A novel series of imidazole appended quinoline derivatives (6a–j) have been synthesized using the one-pot three-component reaction that occurred between the starting materials of substituted 2-phenoxyquinolin-3-carbaldehydes (3a-j), benzil (4), and ammonium acetate (5) by taking equimolar ratio. The newly synthesized imidazole-appended quinolines were subjected to probable inhibition against the anti-diabetic drug target maltase enzyme. The efficacy was tested using in-silico molecular docking analysis and molecular dynamics simulation. The studies revealed that the test 6f ligand (3-(4,5-diphenyl-1H-imidazol-2-yl)-2-phenoxy quinoline) is a strong inhibitor of the target protein maltase when compared with the known inhibitor acarbose and sheds new light on the medicinal chemistry research for the application of the synthesized 6f ligand in the pharmaceutical industry. [ABSTRACT FROM AUTHOR]

An efficient synthesis of new 4-hydroxy-3-(6-aryl-2-(arylamino) pyrimidin-4-yl) quinolin-2(1H)-ones 5a–j, 6a–j, and the evaluation of their antimicrobial activity have been described. Potent antibacterial activity was shown by 6a, 5e, 5f, 6h, 6i, 5j against the testes pathogenic bacteria. Also significant antifungal activity was shown by 6b, 6d, 5e toward selective fungal strains. [ABSTRACT FROM AUTHOR]

A new series of 6-oxo-1,6-dihydropyrimidin-5-carboxamides (4a–m) has been synthesized and reported with good yields. All these compounds were characterized using various spectral techniques such as IR, 1H NMR, 13C NMR, and HRMS and then subjected to in-vitro anti-oxidant and anti-bacterial activities using DPPH and microdilution methods, respectively. Among the synthesized pyrimidine-5-carboxamides, compounds 4a–b, 4j, and 4i were found to exhibit promising antibacterial activity compared to the standard drug Neomycin. Similarly, compounds 4g–i and 4l displayed excellent anti-oxidant activities against the standard drug ascorbic acid. [ABSTRACT FROM AUTHOR]

A new series of bi, tri-podal quinoline derivatives were synthesized by treating substituted phenols of (2-phenoxyquinolin-3-yl)methanols (5a–j) with the brominating reagents such as 1,2-bis(bromomethyl)benzene (6) and 1,3,5-tris(bromomethyl)-2,4,6-trimethylbenzene (8) in the presence of NaH as a base, afforded bi-podal (7a–j) and tri-podal (9a–j) quinoline derivatives respectively. All the newly synthesized compounds (7a–j and 9a–j) were found to be obtained with good yield in lesser time. Generally, single quinoline core moiety possessing molecules are biologically active and were displayed wide range of applications in medicinal field, but here we have synthesized molecules with two, three quinoline moiety, and expect that definitely they may play a greater role in medicinal activities compared with single quinoline possessed molecules and all the newly synthesized bi, tri-podal molecules were subjected to molecular docking studies with alpha-amylase and alpha-glucosidase enzymes to envisage the binding efficacy with comparative studies of standard drug acarbose. [ABSTRACT FROM AUTHOR]