1. Determining the usefulness of serum hyaluronic acid levels as a predictor of progression of hand osteoarthritis: longitudinal analysis from the Iwaki cohort
- Author
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Ryo Inoue, Chiba D, Nakaji S, Sasaki E, Uesato R, Iwasaki H, Ota S, Ishibashi Y, and Saruga T
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Oncology ,medicine.medical_specialty ,Text mining ,business.industry ,Internal medicine ,Cohort ,Medicine ,Serum Hyaluronic Acid ,business ,Hand osteoarthritis - Abstract
Background: Hand osteoarthritis (HOA) causes a significant disfunction in patient’s daily life. The predicting factor of hand osteoarthritis has been unknown. We aimed to investigate the usefulness of serum hyaluronic acid (sHA) levels in predicting progression of HOA from a 6-year longitudinal epidemiological study.Design: In 2008, a total of 417 participants in the Iwaki cohort were followed over 6 years. Hand radiographs were taken at baseline and follow-up and scored according to Kellgren–Lawrence grades and Kallman score for 15 joints. Based on the presence of osteoarthritis, participants were classified into HOA and non-HOA groups. Levels of serum hyaluronic acid (sHA) at baseline were determined by ELISA. Spearman’s correlation coefficients between levels of sHA, total number of involved joints, and Kallman score were estimated. Factors related to increasing number of involved joints over a period of six years were analyzed by liner regression analysis.Results: The prevalence of hand osteoarthritis was 19.9% at baseline and the number of joints involved was 3.6 ± 2.1. Levels of sHA in the HOA group at baseline were significantly higher than non-HOA group (p
- Published
- 2020
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