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1. Evaluación de Andropogon gayanus, Centrosema acutifolium y Pueraria phaseoloides en la cría de terneros destetados precozmente en los Llanos Orientales de Colombia

Author

Vera Raul R. and Sarria B. Doris E.

Subjects
Andropogon gayanus, centrosema acutifolium, Pueraria phaseoloides, cría de terneros, Agriculture
Abstract

Se midió el desarrollo corporal de terneros destetados a los tres meses de edad en pasturas de Andropogon gayanus, A. gayanus + Centrosema acutifolium y A. gayanus + Pueraria phaseoloides. Se utilizaron 10 terneros/tratamiento (70.3 ± 1.73 kg). El ensayo empezó en plena temporada de lluvias, que en este año fueron excesivas y afectaron negativamente la recuperación de las praderas. El desarrollo de los animales se redujo seriamente por la falta de forraje. Se hicieron algunas comparaciones subjetivas con un grupo de terneros que permaneció con sus madres en sabana nativa, hasta los nueve meses de edad, en la cual se realiza el destete tradicional. La cantidad de lluvia no permitió hacer comparaciones entre las pasturas. Los terneros destetados precozmente mostraron un desempeño muy pobre con respecto a los que permanecieron con sus madres; sin embargo, el grupo que pastoreó A. gayanus presentó los peores resultados en ganancia de peso vivo, porcentaje de proteína y minerales en suero, hematocrito, etc., muriendo tres animales por efecto del tratamiento. El destete precoz redujo el anestro posparto de las vacas y mejoró la recuperación de peso de las mismas.The development of early-weaned calves (three months old) in Andropogon gayanus, A. gayanus, Centrosema acutifolium and A. gayanus + Pueraria phaseoloides was investigated. Ten animals were used per treatment; the experiment beginning at the start of the rainy season. In this year 100 % and 45 % more rain fell in may and june respectively than the yearly average for these months. Several subjective comparison were made between the calves in the improved and group maintaned with their mothers in the native savannah until traditional early weaning occurs. The abnormally high rain-fall adverselty affected pasture recovery to the extent that it was impossible to make comparisons between the three pasture treatments. In general, however, all early-weaned calves did not perform as well as those remaining with their mothers. Results from the group in the pure stand of A. gayanus were the worst overall (live weight gains, protein and minerals in serum red blood cell), with three animals dying during the course of the trial. Early-weaning reduced anestrum pospartum and improved weight recovery of the cows.

Published
1988

8. Bioconversion of polyphenols and organic acids by gut microbiota of predigested Hibiscus sabdariffa L. calyces and Agave (A. tequilana Weber) fructans assessed in a dynamic in vitro model (TIM-2) of the human colon

Author

Sayago-Ayerdi, S. G., Sayago-Ayerdi, S. G., Venema, K., Tabernero, M., Sarria, B., Bravo, L., Mateos, R., Sayago-Ayerdi, S. G., Sayago-Ayerdi, S. G., Venema, K., Tabernero, M., Sarria, B., Bravo, L., and Mateos, R.

Abstract

The present work aimed at understanding gut microbiota bioconversion of phenolic compounds (PC) and organic acids in predigested Hibiscus sabdariffa (Hb) calyces and the mixture of Hb and Agave (Agave tequilana Weber) fructans (AF). With this purpose, dried Hb and Hb/AF were predigested with enzymatic treatment, and then fermented in a dynamic in vitro model of the human colon (TIM-2). After HPLC-ESI-QToF-MS analysis of samples taken at 0, 24, 48 and 72 h of fermentation, it was observed that hydroxycinnamic acids, flavanols, flavonols, and anthocyanins were mainly transformed into derivatives of hydroxyphenylpropionic, hydroxyphenylacetic and hydroxybenzoic acids. Moreover, organic acids, such as hydroxycitric and hibiscus acids, were formed along with unidentified lactones and reduced compounds. Interestingly, no differences were observed between microbialderived metabolites formed after the fermentation of Hb and Hb/AF. In conclusion, colonic fermentation of polyphenol-rich Hb yields a wide range of microbial phenolic metabolites with potential effects on health.

Published
2021

11. Efficiency Centered Maintenance of Preheat Train of a Crude Oil Distillation Unit

Author

Fajardo, J., Yabrudy, D., Barreto, D., Negrete, C., Sarria, B., Cardona, C., Fajardo, J., Yabrudy, D., Barreto, D., Negrete, C., Sarria, B., and Cardona, C.

Abstract

Nowadays, maintenance is based on the synergistic integration of operational reliability and timely maintenance, which guarantees the required availability and optimal cost. Operational reliability implies producing more, better performance, longer life, and availability. Timely maintenance involves the least time out of service, fewer maintenance costs, fewer operating costs, and less money. In this work, we study the preheating train of a crude distillation unit of a refinery, which processes 994 m3/h, which presents a formation of a foulinglayer inside it. Among the impacts of fouling is the reduction in the effectiveness of heat transfer, the increase in fuel consumption, the increase in CO2 emissions, the increase in maintenance costs, and the decrease in the profit margin of process. An appropriate cleaning program of the surface of the heat exchanger network is necessary to preserve its key performance parameters, preferably close to design values. This paper presents the maintenance method centered on energy efficiency, to plan the intervention of the preheating train equipment maintenance, which considers the economic energy improvement and the cost of the type of maintenance. The method requires the calculation of the fouling evolution from which the global heat transfer coefficient is obtained, and the heat flux is determined as a function of time. It was observed that, as time passes, the resistance provided by fouling increases and that the overall heat transfer coefficient decreases. The energy efficiency centered maintenance has an indicator of economic justification (factor J) that relates the economic-energy improvement achieved when performing maintenance, taking into account the economic effort invested. Depending on the cost of the type of maintenance to be performed, a threshold should be chosen, from which the maintenance activity is justified. The effectiveness values of the heat exchanger (e) and the J indicator are used to form a criticality

Published
2020

18. Indicators for maintenance planning based on energy efficiency in heat exchanger networks.

Author

Yabrudy-Mercado, D. E., López-Sarria, B. S., Fajardo-Cuadro, J. G., and Cardona-Agudelo, C. A.

Subjects
*HEAT exchanger efficiency, *ENERGY conservation, *ENERGY consumption, *HEAT, *SOLAR stills
Abstract

Thanks to the asset management regulations, modern maintenance practices are rapidly getting a more managerial role, and is used to achieve savings and optimize energy use. Therefore, knowing at all times the status of the equipment allows for timely and necessary interventions that generate value to the company, and recover the initial conditions of them. Heat exchanger networks, rather than a productive asset, constitute an energysaving strategy, to have lower fuel costs, emission control, rational use of energy, etc. in the atmospheric furnaces of the crude distillation units, and other units that perform similar processes. Thus, keeping them in their best conditions, most of the time is necessary. In this paper, we propose a methodology for the diagnosis of the equipment of the network, and the maintenance planning justified by the energy efficiency of them and the economic impact of the intervention. In addition, an indicator is presented to provide an economic justification for maintenance interventions, as well as for briefly showing the results of the application of maintenance mainly on efficiency and the use of the KPI J proposed for programming the maintenance schedule of some of the equipment (pilot test) of the heat exchanger network under study. The methodology developed uses real operation values, and its results provided savings up to USD 150,000. [ABSTRACT FROM AUTHOR]

Published
2020
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19. Thermoeconomic analysis of pvc production plant reactors cooling system

Author

Fajardo Cuadro, Juan Gabriel, Sarria B., Padron J., Barreto D., Fajardo Cuadro, Juan Gabriel, Sarria B., Padron J., and Barreto D.

Abstract

In this work the results of the research made to PVC production plant reactors cooling system are included. The heat generated in the reactor must be removed to maintain its temperature at an optimal range between 50 and 70 °C. To assess the cooling system exergetic and Thermoeconomic indicators were used and it was observed that: (i) The greatest exergetic efficiencies arise in compressors. (ii) The greatest destruction of exergy and reasons of destruction of exergy cost and lower exergoeconomic factors are presented in the evaporative condenser. (iii) The heat exchange equipment has highest relative cost differences. © 2018 ASME.

Published
2017

22. Lung inflammatory pattern and antibiotic treatment in pneumonia

Author

Lorenzo MJ, Moret I, Sarria B, Cases E, Cortijo J, Méndez R, Molina J, Gimeno A, and Menéndez R

Subjects
Lung inflammation, Macrolides, Community acquired pneumonia
Abstract

Background: In community-acquired pneumonia host inflammatory response against the causative microorganism is necessary for infection resolution. However an excessive response can have deleterious effects. In addition to antimicrobial effects, macrolide antibiotics are known to possess immunomodulatory properties. We aimed to evaluate inflammatory cytokine profiles - both locally (bronchoalveolar lavage) and systemically (blood) - in community-acquired pneumonia admitted patients after at least 72 hours of antibiotic treatment (with and without macrolide containing regimens) and requiring bronchoscopic examination for inadequate response due to infection progression and/or lack of clinical stability. Methods: A prospective study was performed on 52 admitted patients who developed an inadequate response after 72 hours of antibiotic treatment -non-responders community-acquired pneumonia - (blood and bronchoalveolar lavage), and two control groups: 1) community-acquired pneumonia control (blood) and 2) non-infection control (blood and bronchoalveolar lavage). Cytokine profiles (interleukin (IL)-6, IL-8, IL-10), tumour necrosis factor a and clinical outcomes were assessed. Results: Non-responders patients treated with macrolide containing regimens showed significantly lower levels of IL-6 and TNF-alpha in bronchoalveolar lavage fluid and lower IL-8 and IL-10 in blood than those patients treated with non-macrolide regimens. Clinical outcomes showed that patients treated with macrolide regimens required fewer days to reach clinical stability (p < 0.01) and shorter hospitalization periods (p < 0.01). Conclusions: After 72 hours of antibiotic effect, patients who received macrolide containing regimens exhibited lower inflammatory cytokine levels in pulmonary and systemic compartments along with faster stabilization of infectious parameters.

Published
2015

23. Exergy study of air-conditioned space of a prototype scale of a river vessel room

Author

Fajardo Cuadro, Juan Gabriel, Guerra M.A., Sarria B., Cruz O., Fajardo Cuadro, Juan Gabriel, Guerra M.A., Sarria B., and Cruz O.

Abstract

The study was conducted on a scale prototype, which simulates one of the rooms in the real vessel air conditioning system. The main results are as follows: the higher the thermal load, the higher the exergy destruction, and increasing the average temperature in the room increases the exergetic efficiency and reduces the exergy destruction. There is an optimal thermal load per unit area of 214.074 W/m2. The highest exergetic efficiencies and lowest values of the exergy destruction indices occur when the average temperature of the room is in the comfort range recommended by ASHRAE, from 22 to 24°C. Copyright © 2016 by ASME.

Published
2016

24. Thermoeconomic indicators ofair conditioning in a river ship to change the configuration of their thermal insulation

Author

Fajardo Cuadro, Juan Gabriel, Sarria B., and Alvarez Guerra M.

Subjects
Destroyed exergy, Cooling load, Polyurethanes, Ship air-conditioning, Exergetic, Second Law of Thermodynamics, Thermo-economics, Costs, Air conditioning, Insulation, Per unit, Thermo-economic, Thermodynamics, Exergy, Investments, Thermal insulation, Ships
Abstract

This work has as object of study the energy of a river ship air conditioning system performance, using fiberglass, polyurethane or rockwool as insulation. Thermoeconomics Indicators based on second law of thermodynamics which take into account the quality of the energy and the cost of the exergy were used for research. It was observed that: (i) by increasing the thickness of the insulation the irreversibilities decreased, (ii) increases in the destroyed exergy increased generation of cooling load costs and (iii) costs per unit of exergy of heat load and area for the generation of cooling load and for investment in exergetic insulation, were minors for polyurethane. Copyright © 2014 by ASME. ASME

Published
2014

26. Thermoeconomic analysis of wheat flour agroindustrial plant

Author

Fajardo Cuadro, Juan Gabriel, Castellon L., Sarria B., Barreto D., Fajardo Cuadro, Juan Gabriel, Castellon L., Sarria B., and Barreto D.

Abstract

This paper presents the development of an exergy and thermoeconomic analysis of a wheat flour agro-industrial plant, which was aimed to evaluate the energy use and establish the operation cost of its components, and to understand the cost formation process and the cost flow. It was found that throughout the production process exists an exergy destruction ratio of 95,08 %. It identified improvement opportunities in relation to cost, has recommended alterations with regard matter flows or an economic investment for change some components with low exergoeconomic factors: 2% planer of wheat bran, 3% knurled roller grinding benches and 5% smooth roller grinding benches. Copyright © 2015 by ASME.

Published
2015

28. Thermoeconomic indicators ofair conditioning in a river ship to change the configuration of their thermal insulation

Author

Fajardo J., Sarria B., Alvarez Guerra M., Fajardo J., Sarria B., and Alvarez Guerra M.

Abstract

This work has as object of study the energy of a river ship air conditioning system performance, using fiberglass, polyurethane or rockwool as insulation. Thermoeconomics Indicators based on second law of thermodynamics which take into account the quality of the energy and the cost of the exergy were used for research. It was observed that: (i) by increasing the thickness of the insulation the irreversibilities decreased, (ii) increases in the destroyed exergy increased generation of cooling load costs and (iii) costs per unit of exergy of heat load and area for the generation of cooling load and for investment in exergetic insulation, were minors for polyurethane. Copyright © 2014 by ASME.

Published
2014

42. Does bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal women?

Author

Schoppen, S., Sanchez-Muniz, F. J., Perez-Granados, A. M., Gomez-Gerique, J. A., Sarria, B., Navas-Carretero, S., and M Pilar Vaquero

Subjects
lcsh:Nutritional diseases. Deficiency diseases, Glucose, Agua mineral bicarbonatada, Flúor, Insulina, Sodium, Glucosa, Sodio, Insulin, Fluoride, lcsh:RC620-627, Bicarbonated mineral water
Abstract

Aim: To study the effects of drinking 0.5 L of two sodium-rich bicarbonated mineral waters (BMW-1 and 2), with a standard meal, on postprandial insulin and glucose changes. And to determine, if the effects vary depending on insulin resistance, measured by homeostasis model assessment (HOMA). Methods: In a 3-way randomized crossover study, 18 healthy postmenopausal women consumed two sodiumrich BMWs and a low-mineral water (LMW) with a standard fat-rich meal. Fasting and postprandial blood samples were taken at 30, 60 and 120 min. Serum glucose, insulin, cholesterol and triacylglycerols were determined. Insulin resistance was estimated by HOMA and insulin sensitivity was calculated by quantitative insulin sensitivity check index (QUICKY). Results: Glucose levels did not change. HOMA and QUICKY values were highly inversely correlated (r = -1,000; p < 0.0001). Insulin concentrations showed a significant time effect (p < 0.0001) and a significant water x time interaction (p < 0.021). At 120 min insulin levels with BMW-1 were significantly lower than with LMW (p = 0.022). Postprandial insulin concentrations showed significantly different patterns of mineral water intake depending on HOMA n-tiles (p = 0.016). Conclusion: Results suggests an increase in insulin sensitivity after BMWs consumption. This effect is more marked in the women, who have higher HOMA values. These waters should be considered part of a healthy diet in order to prevent insulin resistance and cardiovascular disease.

45. Effects of antisecretory drugs on mucosal erosions induced by intragastric distension in rats: A comparative study

Author

Martí-Cabrera M, Jv, Esplugues, Luis Marti-Bonmati, Sarria B, Vento A, Martí-Bonmati E, Gil L, and Esplugues J

Subjects
Male, Gastric Mucosa, Prostaglandins E, Carbenoxolone, Animals, Rats, Inbred Strains, Pirenzepine, Stomach Ulcer, In Vitro Techniques, Cimetidine, Dinoprostone, Rats
Abstract

The antiulcer effects of two classical antisecretory agents, cimetidine and pirenzepine, were compared with those of prostaglandin E2 and carbenoxolone sodium. The acid inhibitory action of drugs was not important in our study since the ulcer model employed consisted of perfusing the stomach continuously, at a high intraluminal pressure (120 mm H2O), with a simulated gastric juice (0.1 M HCl plus 600 mg pepsin/l). Cimetidine and pirenzepine failed to inhibit gastric erosions, whereas prostaglandin E2 and carbenoxolone greatly reduced the severity of the mucosal lesions. Long-term treatment with cimetidine did not prevent gastric damage. These findings indicate that pure antisecretory agents do not directly increase the capacity of the mucosa to resist damage.

47. Effects of regularly consuming dietary fibre rich soluble cocoa products on bowel habits in healthy subjects: a free-living, two-stage, randomized, crossover, single-blind intervention

Author

Sarriá Beatriz, Martínez-López Sara, Fernández-Espinosa Aránzazu, Gómez-Juaristi Miren, Goya Luis, Mateos Raquel, and Bravo Laura

Subjects
Dietary fibre, Cocoa, Bowel function, Gastrointestinal transit time, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background Dietary fibre is both preventive and therapeutic for bowel functional diseases. Soluble cocoa products are good sources of dietary fibre that may be supplemented with this dietary component. This study assessed the effects of regularly consuming two soluble cocoa products (A and B) with different non-starch polysaccharides levels (NSP, 15.1 and 22.0% w/w, respectively) on bowel habits using subjective intestinal function and symptom questionnaires, a daily diary and a faecal marker in healthy individuals. Methods A free-living, two-stage, randomized, crossover, single-blind intervention was carried out in 44 healthy men and women, between 18-55 y old, who had not taken dietary supplements, laxatives, or antibiotics six months before the start of the study. In the four-week-long intervention stages, separated by a three-week-wash-out stage, two servings of A and B, that provided 2.26 vs. 6.60 g/day of NSP respectively, were taken. In each stage, volunteers' diet was recorded using a 72-h food intake report. Results Regularly consuming cocoa A and B increased fibre intake, although only cocoa B significantly increased fibre intake (p < 0.001) with respect to the non-cocoa stage. No changes in body weight were observed in either of the 4 week interventions. With cocoa product B, the number of daily bowel movements increased (p = 0.002), the frequency of having a bowel movement once a day increased (p = 0.009), the time to have a bowel movement was lower (p = 0.016) as well as the feeling of constipation (p = 0.046) without inducing adverse gastrointestinal symptoms, only flatulence increased (p = 0.019). Conclusions Regular consumption of the cocoa products increases dietary fibre intake to recommended levels and product B improves bowel habits. The use of both objective and subjective assessments to evaluate the effects of food on bowel habits is recommended.

Published
2012
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48. Las pinturas rupestres de Cova Remigia (Ares del Maeste, Castellón)

Author

Sarriá Boscovich, Elisa

Subjects
Prehistoric archaeology, GN700-890, Archaeology, CC1-960
Abstract

Síntesis de las investigaciones llevadas a cabo en "Cova Remigia", Ares del Maestre (Castellón). Se ha realizado una revisión a partir de una base de datos, codificando los diferentes elementos y características de los pictogramas: tipología, conservación, técnica, tamaño y color, etc., que han permitido la identificación de seis momentos diferentes en la realización del panel.

Published
1988
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49. Aislamiento, selección y caracterización de una bacteria ácido láctica porcina como probiótico en lechones post destete

Author

Rebolledo Londoño, Ángelo, Martens, Siriwan D., Sarria B., Patricia Isabel, D. Martens, Siriwan, and Sarria B., Patricia I.

Subjects
63 Agricultura y tecnologías relacionadas / Agriculture, Lactic Acid Bacteria, Piglets, Salud y Nutrición Animal, Animal Health and Nutrition, Probiotics, Lactobacillus plantaru, Probióticos, Bacterias Ácido Lácticas, Lechones, Lactobacillus plantarum
Abstract

Con el objetivo de identificar y caracterizar bacterias acido lácticas BAL de origen porcino asociadas al estado de sanidad intestinal de los lechones posdestete, se llevó a cabo un experimento donde se aislaron 38 cepas de BAL para evaluar su potencial de colonización del tracto gastrointestinal a través de la prueba de in vitro de adhesión y aglutinación a mannosa. Se seleccionó la BAL L605 y se evaluó su capacidad para fermentar alimentos balanceados basados en maíz y soya, utilizados en lechones destetos a los 21 días de edad. A través de la metodología de Reacción en Cadena de la Polimerasa PCR, se determinó que la cepa seleccionada pertenecía a la especie Lactobacilus plantarum. Posteriormente se utilizaron 18 lechones en la fase de lactancia, destete y post destete distribuidos en tres tratamientos (n=6) CT+: Tratamiento control positivo (con el antibiótico clortetraciclina clorhidrato); CT: Tratamiento control negativo sin adición de BAL y sin antibiótico, y T Fermentado: Tratamiento fermentado con la adición de la BAL L605. Se observó diarrea en algunos animales del tratamiento CT+. Se tomaron muestras de alimento y materia fecal de los tres tratamientos a los 15, 22 y 26 ±1 días de edad. Las muestras de alimento y materia fecal fueron estandarizadas para detectar y cuantificar la especie L. plantarum por el método molecular de reacción en cadena de la polimerasa en tiempo real (Q-PCR). Con el fin de identificar de manera rápida la BAL L605 en cualquier muestra de interés, se utilizó la técnica de Amplificación del ADN Polimórfico al Azar (RAPD), por medio de la creación de primers específicos. Se logró aislar la BAL L605 con características probióticas y reproducirla para fermentar alimentos de lechones. A través de las técnicas moleculares fue posible detectar y cuantificar la BAL inoculada en el alimento y en las heces de los animales. La adición de un microorganismo como la BAL L605 con acción probiótico puede ser una opción para prevenir los problemas de salud intestinal a los lechones destetados precozmente. //Abstract: In order to identify and characterize lactic acid bacteria (LAB) associated with porcine intestinal health status of piglets after weaning, an experiment was conducted where 38 LAB strains were isolated to assess their potential for colonization of the gastrointestinal tract through testing and adhesion to mannose in vitro. LAB L605 was selected and tested for its ability to ferment balanced meals based on corn and soybeans, used in piglets weaned at 21 days of age. By Polymerase Chain Reaction (PCR), we determined that the selected strain belongs to the species Lactobacillus plantarum. In the feeding experiment, 18 piglets were used in the phase of lactation, weaning and post-weaning divided into three treatments (n = 6) CT +: positive control treatment (with the antibiotic chlortetracycline hydrochloride); CT -: negative control treatment without added LAB and without antibiotic, and T Fermented: fermented with the addition of LAB L605 . Diarrhea was observed in some animals in the CT + treatment. Feed samples and feces of the piglets of the three treatments at 15, 22 and 26 ± 1 days of age were studied. Samples of food and feces were standardized to detect and quantify the species L. plantarum molecularly by real time quantitative Polymerase Chain Reaction (qRT-PCR). To quickly identify the LAB L605 in any sample of interest, the technique of DNA amplification Random Polymorphic (RAPD) was used, through the creation of specific primers. using molecular techniques it was possible to detect and quantify the LAB inoculated in the feed and excreted in the feces of animals. The addition of a microorganism such as LAB L605 with probiotic activity may be an option to prevent intestinal health problems in early weaned piglets. Maestría

Published
2014

50. Myeloid-derived suppressor cells as a potential biomarker for recurrent pregnancy loss and recurrent implantation failure: Increased levels of MDSCs in recurrent reproductive failure.

Author

Marin NS, Fuente-Muñoz E, Gil-Laborda R, Villegas Á, Alonso-Arenilla B, Cristóbal I, Pilar-Suárez L, Jiménez-Huete A, Calvo M, Sarria B, Mansilla-Ruiz M, Ochoa J, Fernández-Arquero M, and Sánchez-Ramón S

Subjects
Pregnancy, Humans, Female, T-Lymphocytes, Regulatory, Fertility, Biomarkers, Myeloid-Derived Suppressor Cells, Abortion, Habitual diagnosis
Abstract

Problem: Recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) represent distinct clinical conditions with established definitions, both of which have been linked to an underlying pro-inflammatory state. This study aimed to explore the levels of monocytic-myeloid-derived suppressor cells (M-MDSCs) and regulatory T cells (T Reg ) in a cohort of RPL and RIF women and their potential contribution to RPL and RIF., Method of Study: One hundred and eight non-pregnant women were evaluated: 40 RPL, 41 RIF, and 27 fertile healthy controls (HC). A multiparametric flow cytometry approach was utilized to measure and quantify the frequency of M-MDSCs and T Reg cells. Cytokine levels in plasma samples were evaluated through a multiplex assay. M-MDSCs levels were significantly higher in RPL and RIF patients compared to HC., Results: M-MDSCs levels were significantly higher in RPL (9.4% [7-11.6]) and RIF (8.1% [5.9-11.6]) patients compared to HC (6% [4.2-7.6]). An optimal cut-off of 6.1% for M-MDSCs disclosed a sensitivity of 75.6% and 89.7% and a specificity of 57.7% and 57.7% in RIF and RPL groups, respectively. A significant negative correlation was observed between M-MDSCs and T Reg (p = .002, r = -.51)., Conclusions: Our preliminary data allowed us to build a predictive model that may aid as a potential diagnostic tool in the clinic. These findings could provide a better understanding of these pathologies and a better definition of patients that could benefit from personalized treatments to promote pregnancy. Additional exploration and confirmation in distinct study groups are needed to fully assess the diagnostic capabilities of this biomarker., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2023
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