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8 results on '"Sarrecchia B"'

3. Hepatitis B virus DNA in chronic HBsAg carriers: correlation with HBeAg/anti-HBe status, anti-HD and liver histology

Author

Stroffolini T, Evangelista Sagnelli, Rapicetta M, Fm, Felaco, Filippini P, Annella T, Petruzziello A, Chionne P, Sarrecchia B, Piccinino F, Stroffolini, T, Sagnelli, E, Rapicetta, M, Felaco, Fm, Filippini, Pietro, Annella, T, Petruzziello, A, Chionne, P, Sarrecchia, B, and Piccinino, F.

Subjects
Adult, Male, Hepatitis B virus, Hepatitis B Surface Antigens, Adolescent, Radioimmunoassay, Nucleic Acid Hybridization, Middle Aged, Hepatitis B, Liver, Child, Preschool, Carrier State, Chronic Disease, DNA, Viral, Humans, Female, Hepatitis Antibodies, Hepatitis B e Antigens, Hepatitis Delta Virus, Child
Abstract

Hepatitis B virus DNA was determined in the sera of 198 chronic hepatitis B surface antigen (HBsAg) carriers by the spot hybridization technique. The results were correlated with hepatitis Be antigen (HBeAg) and antibody (anti-HBe), delta antibody (anti-HD) and liver histology. All subjects had a liver biopsy. The prevalence of HBV DNA was 63% in HBeAg-positive subjects and 8.8% in anti-HBe positives. HBV DNA was not found more frequently in chronic HBsAg carriers who had histological evidence of liver disease than in carriers without such evidence. Anti-HD was detected in 48.5% of subjects, with an increasing trend (p less than 0.001) according to the severity of liver disease. Among patients with more severe liver disease (CAH and cirrhosis), HBV DNA and HBeAg were detected less frequently in anti-HD-positive than in anti-HD-negative subjects (7% vs. 42.3%, p less than 0.001 and 7% vs. 34.4%, p less than 0.005, respectively). These findings indicate that HDV infection jointly affects both HBeAg status and HBV DNA.

Published
1992

8. A high degree of exposure to hepatitis A virus infection in urban children in Cameroon.

Author

Stroffolini T, Chiaramonte M, Ngatchu T, Rapicetta M, Sarrecchia B, Chionne P, Lantum D, and Naccarato R

Subjects
Adolescent, Cameroon epidemiology, Child, Enzyme-Linked Immunosorbent Assay, Female, Hepatitis A Antibodies, Humans, Immunoglobulin G analysis, Male, Prevalence, Socioeconomic Factors, Urban Population, Hepatitis A epidemiology, Hepatitis Antibodies blood, Hepatovirus immunology
Abstract

In January 1989, the prevalence of antibodies to hepatitis A virus (anti-HAV) was determined by ELISA in 702 apparently healthy children 5-14 years old in Kumba City, Cameroon. Children were recruited from those attending six different primary schools, representative of the socio-demographic characteristics of the inhabitants, using a systematic random sampling. The overall IgG anti-HAV prevalence was 96.9%, reaching 100% by the age of 11 years. In primary school beginners the prevalence was very high, 94.0%, contrary to what has been observed in developed countries. The anti-HAV prevalence was not associated with family size, but was related to parent's occupation, children from the lower class having a 5.9 fold risk (C.I. = 1.9-18.3) of past exposure to HAV. These results suggest a persistently high prevalence of anti-HAV in children despite improving hygienic conditions. The spread of HAV in this population may be the result of domestic water and/or food contamination.

Published
1991

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