Search

Hydrotropic solubilization is a technique that can be used to improve the solubility of drugs that are poorly soluble. This technique involves adding a large amount of a second solute, known as a hydrotrope, which increases the aqueous solubility of the poorly soluble drug. Hydrotropes such as sodium citrate, sodium benzoate, and urea have been shown to be effective in enhancing the solubility of poorly soluble drugs. This technique has several advantages over other solubility enhancement techniques, including its cost-effectiveness, eco-friendliness, and the fact that it does not require chemical modification of hydrophobic drugs or the use of organic solvents. Hydrotropic agents are now being used to develop various dosage forms, including solid dispersions, mouth-dissolving tablets, and injections, to improve poorly water-soluble drugs' therapeutic effectiveness and bioavailability. This review paper will provide an overview of hydrotropic solubilization techniques. [ABSTRACT FROM AUTHOR]

Delivery of drugs through the skin has been an attractive as well as a challenging area for research. Compared to other conventional routes of drug delivery such as oral, injection and inhaler, transdermal delivery has a variety of advantages. Transdermal systems are non-invasive, convenient, and inexpensive and can be self-administered. They can provide sustained plasma concentration profile for long periods of time. There are many transdermal formulations like lotions, creams, ointments, patches, etc. out of these gel is preferred. Transdermal gels are becoming more popular due to ease of application and better precutaneous absorption. The term gel are semi-solid, three dimensional, polymeric matrices comprising small amounts of solid dispersed in relatively large amount of liquid, yet possessing more solid like character. These system form a three dimensional, polymeric matrix in which a high degree of physical reticulation has been compromised. Gel formulations provide better application property and stability in comparison to cream and ointments. In these study methods, advantages, gel forming substances, structure of gel, their properties, their absorption mechanism, evaluation and future perspective are discussed to improve the permeability and bioavailability of gels. [ABSTRACT FROM AUTHOR]