Search

Your search keyword '"Saro, Jose"' showing total 19 results
Start Over Author "Saro, Jose"
19 results on '"Saro, Jose"'

1. Supplemental Figure 2 from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Author

Bacac, Marina, primary, Fauti, Tanja, primary, Sam, Johannes, primary, Colombetti, Sara, primary, Weinzierl, Tina, primary, Ouaret, Djamila, primary, Bodmer, Walter, primary, Lehmann, Steffi, primary, Hofer, Thomas, primary, Hosse, Ralf J., primary, Moessner, Ekkehard, primary, Ast, Oliver, primary, Bruenker, Peter, primary, Grau-Richards, Sandra, primary, Schaller, Teilo, primary, Seidl, Annette, primary, Gerdes, Christian, primary, Perro, Mario, primary, Nicolini, Valeria, primary, Steinhoff, Nathalie, primary, Dudal, Sherri, primary, Neumann, Sebastian, primary, von Hirschheydt, Thomas, primary, Jaeger, Christiane, primary, Saro, Jose, primary, Karanikas, Vaios, primary, Klein, Christian, primary, and Umaña, Pablo, primary

Published
2023
Full Text
View/download PDF

2. Supplemental Information from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Author

Bacac, Marina, primary, Fauti, Tanja, primary, Sam, Johannes, primary, Colombetti, Sara, primary, Weinzierl, Tina, primary, Ouaret, Djamila, primary, Bodmer, Walter, primary, Lehmann, Steffi, primary, Hofer, Thomas, primary, Hosse, Ralf J., primary, Moessner, Ekkehard, primary, Ast, Oliver, primary, Bruenker, Peter, primary, Grau-Richards, Sandra, primary, Schaller, Teilo, primary, Seidl, Annette, primary, Gerdes, Christian, primary, Perro, Mario, primary, Nicolini, Valeria, primary, Steinhoff, Nathalie, primary, Dudal, Sherri, primary, Neumann, Sebastian, primary, von Hirschheydt, Thomas, primary, Jaeger, Christiane, primary, Saro, Jose, primary, Karanikas, Vaios, primary, Klein, Christian, primary, and Umaña, Pablo, primary

Published
2023
Full Text
View/download PDF

3. Table S1 from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Author

Bacac, Marina, primary, Fauti, Tanja, primary, Sam, Johannes, primary, Colombetti, Sara, primary, Weinzierl, Tina, primary, Ouaret, Djamila, primary, Bodmer, Walter, primary, Lehmann, Steffi, primary, Hofer, Thomas, primary, Hosse, Ralf J., primary, Moessner, Ekkehard, primary, Ast, Oliver, primary, Bruenker, Peter, primary, Grau-Richards, Sandra, primary, Schaller, Teilo, primary, Seidl, Annette, primary, Gerdes, Christian, primary, Perro, Mario, primary, Nicolini, Valeria, primary, Steinhoff, Nathalie, primary, Dudal, Sherri, primary, Neumann, Sebastian, primary, von Hirschheydt, Thomas, primary, Jaeger, Christiane, primary, Saro, Jose, primary, Karanikas, Vaios, primary, Klein, Christian, primary, and Umaña, Pablo, primary

Published
2023
Full Text
View/download PDF

4. Supplemental Figure 3 from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Author

Bacac, Marina, primary, Fauti, Tanja, primary, Sam, Johannes, primary, Colombetti, Sara, primary, Weinzierl, Tina, primary, Ouaret, Djamila, primary, Bodmer, Walter, primary, Lehmann, Steffi, primary, Hofer, Thomas, primary, Hosse, Ralf J., primary, Moessner, Ekkehard, primary, Ast, Oliver, primary, Bruenker, Peter, primary, Grau-Richards, Sandra, primary, Schaller, Teilo, primary, Seidl, Annette, primary, Gerdes, Christian, primary, Perro, Mario, primary, Nicolini, Valeria, primary, Steinhoff, Nathalie, primary, Dudal, Sherri, primary, Neumann, Sebastian, primary, von Hirschheydt, Thomas, primary, Jaeger, Christiane, primary, Saro, Jose, primary, Karanikas, Vaios, primary, Klein, Christian, primary, and Umaña, Pablo, primary

Published
2023
Full Text
View/download PDF

5. Supplemental Figure 1 from A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Author

Bacac, Marina, primary, Fauti, Tanja, primary, Sam, Johannes, primary, Colombetti, Sara, primary, Weinzierl, Tina, primary, Ouaret, Djamila, primary, Bodmer, Walter, primary, Lehmann, Steffi, primary, Hofer, Thomas, primary, Hosse, Ralf J., primary, Moessner, Ekkehard, primary, Ast, Oliver, primary, Bruenker, Peter, primary, Grau-Richards, Sandra, primary, Schaller, Teilo, primary, Seidl, Annette, primary, Gerdes, Christian, primary, Perro, Mario, primary, Nicolini, Valeria, primary, Steinhoff, Nathalie, primary, Dudal, Sherri, primary, Neumann, Sebastian, primary, von Hirschheydt, Thomas, primary, Jaeger, Christiane, primary, Saro, Jose, primary, Karanikas, Vaios, primary, Klein, Christian, primary, and Umaña, Pablo, primary

Published
2023
Full Text
View/download PDF

6. Preliminary clinical outcomes of ADP-A2M4CD8, a next-generation autologous T-cell receptor T-cell therapy, in patients with advanced urothelial cancer.

Author

Aggen, David H, primary, Hong, David S., additional, Clarke, Jeffrey Melson, additional, Asch, Adam Steven, additional, Calvo, Emiliano, additional, Zugazagoitia, Jon, additional, Butler, Marcus O., additional, Moreno, Victor, additional, Cervantes, Andres, additional, Van Tine, Brian Andrew, additional, Lawrence, Donald P., additional, Johnson, Melissa Lynne, additional, Brophy, Francine Elizabeth, additional, Broad, Robyn, additional, Isabelle, Martin, additional, Gunn, Alasdair, additional, Navenot, Jean-Marc, additional, Saro, Jose, additional, Norry, Elliot, additional, and Charlson, John A., additional

Published
2023
Full Text
View/download PDF

7. Safety and efficacy from the phase 1 SURPASS trial of ADP-A2M4CD8, a next-generation T-cell receptor T-cell therapy, in patients with advanced esophageal, esophagogastric junction, or gastric cancer.

Author

Blum Murphy, Mariela A., primary, Ajani, Jaffer A., additional, Van Tine, Brian Andrew, additional, Clarke, Jeffrey Melson, additional, Butler, Marcus O., additional, Lawrence, Donald P., additional, Johnson, Melissa Lynne, additional, Cervantes, Andres, additional, Moreno, Victor, additional, Hong, David S., additional, Brophy, Francine Elizabeth, additional, Navenot, Jean-Marc, additional, Lin, Quan, additional, Saro, Jose, additional, and Norry, Elliot, additional

Published
2023
Full Text
View/download PDF

8. 2022-LBA-414-ESGO Preliminary clinical outcome of ADP-A2M4CD8, a next-generation autologous T-cell receptor T-cell therapy, in patients with advanced epithelial ovarian cancer

Author

Moore, Kathleen, primary, Asch, Adam, additional, Moreno, Victor, additional, Calvo, Emiliano, additional, Butler, Marcus, additional, Zugazagoitia, Jon, additional, Hong, David, additional, Galal, Ahmed, additional, Ostios, Lorena, additional, de Miguel, Maria, additional, Lin, Quan, additional, Annareddy, Thejo, additional, Brophy, Francine, additional, Rosenberg, Marisa, additional, Seiders, Theresa, additional, Naidoo, Revashnee, additional, Bath, Natalie, additional, Saro, Jose, additional, Norry, Elliot, additional, and Clarke, Jeffrey, additional

Published
2022
Full Text
View/download PDF

9. 89Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding

Author

Sub Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, van Brummelen, Emilie M J, Huisman, Marc C, de Wit-van der Veen, Linda J, Nayak, Tapan K, Stokkel, Marcel P M, Mulder, Emma R, Hoekstra, Otto S, Vugts, Danielle J, Van Dongen, Guus A M S, Verheul, Henk M, Evers, Stefan, Tessier, Jean J L, Saro, Jose, Schellens, Jan H M, Menke-van der Houven van Oordt, C Willemien, Sub Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, van Brummelen, Emilie M J, Huisman, Marc C, de Wit-van der Veen, Linda J, Nayak, Tapan K, Stokkel, Marcel P M, Mulder, Emma R, Hoekstra, Otto S, Vugts, Danielle J, Van Dongen, Guus A M S, Verheul, Henk M, Evers, Stefan, Tessier, Jean J L, Saro, Jose, Schellens, Jan H M, and Menke-van der Houven van Oordt, C Willemien

Published
2018

10. 89Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding

Author

van Brummelen, Emilie M.J., primary, Huisman, Marc C., additional, de Wit-van der Veen, Linda J., additional, Nayak, Tapan K., additional, Stokkel, Marcel P.M., additional, Mulder, Emma R., additional, Hoekstra, Otto S., additional, Vugts, Danielle J., additional, Van Dongen, Guus A.M.S., additional, Verheul, Henk M., additional, Evers, Stefan, additional, Tessier, Jean J. L., additional, Saro, Jose, additional, Schellens, Jan H.M., additional, and Menke-van der Houven van Oordt, C. Willemien, additional

Published
2018
Full Text
View/download PDF

11. La función social de la segunda república en Cantabria: las cantinas escolares

Author

Mazorra Saro, Jose, Castro Zubizarreta, Ana, and Universidad de Cantabria

Subjects
Second Spanish Republic, Caridad, Charity, Cantina escolar, Solidaridad, Segunda República Española, School canteen, Solidarity
Abstract

RESUMEN: Este trabajo trata de reflejar la función social de las Cantinas Escolares en la Segunda República en Cantabria. Para ello, se ha llevado a cabo un análisis de diferentes artículos de periódico de aquella época, así como un repaso de la legislación referente a aquellas cantinas. Previamente hemos dejado constancia de la situación socioeconómica que Cantabria vivió durante aquellos años con el objetivo de comprender mejor la situación y el carácter de las Cantinas. Por último, y con el fin de remarcar el cambio sustancial que se produjo en el carácter de las Cantinas Escolares con la llegada de la Segunda República, hemos realizado un análisis comparativo con los comedores escolares actuales y con los existentes anteriores a la II República. ABSTRACT: This dissertation attempts to reflect the social function of School Canteens in the Second Spanish Republic in Cantabria. To do so, we carried out an analysis of several newspaper articles of that era, as well as a review of legislation concerning those School Canteens. Previously we have gone on record the socioeconomic situation which Cantabria lived during those years in order to have a better understanding of the situation and nature of the School Canteens. Finally, in order to emphasize the substantial change which took place in the character of school canteens with the arrival of the Second Spanish Republic, we performed a comparative analysis with current school canteens and existing prior to the Second Republic. Grado en Magisterio en Educación Primaria

Published
2016

12. Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

Author

Klein, Christian, primary, Waldhauer, Inja, additional, Nicolini, Valeria G., additional, Freimoser-Grundschober, Anne, additional, Nayak, Tapan, additional, Vugts, Danielle J., additional, Dunn, Claire, additional, Bolijn, Marije, additional, Benz, Jörg, additional, Stihle, Martine, additional, Lang, Sabine, additional, Roemmele, Michaele, additional, Hofer, Thomas, additional, van Puijenbroek, Erwin, additional, Wittig, David, additional, Moser, Samuel, additional, Ast, Oliver, additional, Brünker, Peter, additional, Gorr, Ingo H., additional, Neumann, Sebastian, additional, de Vera Mudry, Maria Cristina, additional, Hinton, Heather, additional, Crameri, Flavio, additional, Saro, Jose, additional, Evers, Stefan, additional, Gerdes, Christian, additional, Bacac, Marina, additional, van Dongen, Guus, additional, Moessner, Ekkehard, additional, and Umaña, Pablo, additional

Published
2017
Full Text
View/download PDF

15. A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Author

Bacac, Marina, primary, Fauti, Tanja, additional, Sam, Johannes, additional, Colombetti, Sara, additional, Weinzierl, Tina, additional, Ouaret, Djamila, additional, Bodmer, Walter, additional, Lehmann, Steffi, additional, Hofer, Thomas, additional, Hosse, Ralf J., additional, Moessner, Ekkehard, additional, Ast, Oliver, additional, Bruenker, Peter, additional, Grau-Richards, Sandra, additional, Schaller, Teilo, additional, Seidl, Annette, additional, Gerdes, Christian, additional, Perro, Mario, additional, Nicolini, Valeria, additional, Steinhoff, Nathalie, additional, Dudal, Sherri, additional, Neumann, Sebastian, additional, von Hirschheydt, Thomas, additional, Jaeger, Christiane, additional, Saro, Jose, additional, Karanikas, Vaios, additional, Klein, Christian, additional, and Umaña, Pablo, additional

Published
2016
Full Text
View/download PDF

16. Abstract 2481: CEA TCB, a novel T-cell bispecific antibody with potent in vitro and in vivo antitumor activity against solid tumors

Author

Bacac, Marina, primary, Fauti, Tanja, additional, Colombetti, Sara, additional, Sam, Johannes, additional, Nicolini, Valeria, additional, Steinhoff, Nathalie, additional, Ast, Oliver, additional, Bruenker, Peter, additional, Hosse, Ralf, additional, Hofer, Thomas, additional, Moessner, Ekkehard, additional, Jaeger, Christiane, additional, Saro, Jose, additional, Karanikas, Vaios, additional, Klein, Christian, additional, and Umana, Pablo, additional

Published
2015
Full Text
View/download PDF

17. ITOC2 – 037. CEA TCB, A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours

Author

Bacac, Marina, primary, Fauti, Tanja, additional, Colombetti, Sara, additional, Sam, Johannes, additional, Nicolini, Valeria, additional, Steinhoff, Nathalie, additional, Ast, Oliver, additional, Bruenker, Peter, additional, Hosse, Ralf, additional, Hofer, Thomas, additional, Moessner, Ekkehard, additional, Jaeger, Christiane, additional, Saro, Jose, additional, Karanikas, Vaios, additional, Klein, Christian, additional, and Umaña, Pablo, additional

Published
2015
Full Text
View/download PDF

19. 89 Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding.

Author

van Brummelen EMJ, Huisman MC, de Wit-van der Veen LJ, Nayak TK, Stokkel MPM, Mulder ER, Hoekstra OS, Vugts DJ, Van Dongen GAMS, Verheul HM, Evers S, Tessier JJL, Saro J, Schellens JHM, and Menke-van der Houven van Oordt CW

Abstract

Cergutuzumab amunaleukin (CEA-IL2v) is an immunocytokine directed against carcinoembryonic antigen (CEA) containing an IL2v-moiety with abolished IL-2 receptor (IL-2R) α binding. We describe the biodistribution and tumor accumulation of 89 Zr-labeled CEA-IL2v. Twenty-four patients with advanced solid CEA positive (CEA+) or negative (CEA-) tumors received CEA-IL2v 6 mg (4 CEA+; 3 CEA-), 20 mg (9 CEA+), or 30 mg (4 CEA+; 4 CEA-) biweekly. In cycle 1, 2 mg of the total dose comprised 89 Zr-CEA-IL2v (50 MBq) and serial 89 Zr-PET imaging was conducted. Four CEA+ patients with visually confirmed 89 Zr-CEA-IL2v tumor accumulation at 20 mg had repeated 89 Zr-PET imaging during cycle 4. 89 Zr-CEA-IL2v immuno-PET demonstrated preferential drug accumulation in CEA+ tumors (%ID/mL peak CEA- 3.6 × 10 -3 vs. CEA+ 6.7 ×∙10 -3 ). There was a non-significant trend towards dose-dependent tumor uptake, with higher uptake at doses ≥20 mg. Biodistribution was dose- and CEA-independent with major accumulation in lymphoid tissue compatible with IL-2R binding. Reduced exposure and reduced tumor accumulation (%ID/mL peak 57% lower) on cycle 4 vs. cycle 1 was consistent with peripheral expansion of immune cells. The findings of this immune PET imaging study with 89 Zr-CEA-IL2v support the therapeutic concept of CEA-IL2v, confirming selective and targeted tumor accumulation with this novel immunocytokine., Competing Interests: CONFLICTS OF INTEREST T.N. is a former employee of Roche; J.J.L.T. and J.S. are employees of Roche; S.E. is an employee and shareholder of Roche; the other authors have nothing to disclose.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results