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4. Voeding en sport

Author

Van Loon, L. J. C., Saris, W. H. M., Mosterd, W. L., editor, Sitsen, J. M. A., editor, Hermans, G. P. H., editor, Backx, F. J. G., editor, and Van Cingel, R. E. H., editor

Published
2005
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8. Personalised nutrition advice reduces intake of discretionary foods and beverages: findings from the Food4Me randomised controlled trial

Author

Livingstone, Katherine M., Celis-Morales, C, Navas-Carretero, S, San-Cristobal, R, Forster, H, Woolhead, C, O’Donovan, C B, Moschonis, G, Manios, Y, Traczyk, I, Gundersen, T E, Drevon, C A, Marsaux, C F M, Fallaize, R, Macready, A L, Daniel, H, Saris, W H M, Lovegrove, J A, Gibney, M, Gibney, E R, Walsh, M, Brennan, L, Martinez, J A, Mathers, J C, Livingstone, Katherine M., Celis-Morales, C, Navas-Carretero, S, San-Cristobal, R, Forster, H, Woolhead, C, O’Donovan, C B, Moschonis, G, Manios, Y, Traczyk, I, Gundersen, T E, Drevon, C A, Marsaux, C F M, Fallaize, R, Macready, A L, Daniel, H, Saris, W H M, Lovegrove, J A, Gibney, M, Gibney, E R, Walsh, M, Brennan, L, Martinez, J A, and Mathers, J C

Abstract

Background The effect of personalised nutrition advice on discretionary foods intake is unknown. To date, two national classifications for discretionary foods have been derived. This study examined changes in intake of discretionary foods and beverages following a personalised nutrition intervention using these two classifications. Methods Participants were recruited into a 6-month RCT across seven European countries (Food4Me) and were randomised to receive generalised dietary advice (control) or one of three levels of personalised nutrition advice (based on diet [L1], phenotype [L2] and genotype [L3]). Dietary intake was derived from an FFQ. An analysis of covariance was used to determine intervention effects at month 6 between personalised nutrition (overall and by levels) and control on i) percentage energy from discretionary items and ii) percentage contribution of total fat, SFA, total sugars and salt to discretionary intake, defined by Food Standards Scotland (FSS) and Australian Dietary Guidelines (ADG) classifications. Results Of the 1607 adults at baseline, n = 1270 (57% female) completed the intervention. Percentage sugars from FSS discretionary items was lower in personalised nutrition vs control (19.0 ± 0.37 vs 21.1 ± 0.65; P = 0.005). Percentage energy (31.2 ± 0.59 vs 32.7 ± 0.59; P = 0.031), percentage total fat (31.5 ± 0.37 vs 33.3 ± 0.65; P = 0.021), SFA (36.0 ± 0.43 vs 37.8 ± 0.75; P = 0.034) and sugars (31.7 ± 0.44 vs 34.7 ± 0.78; P < 0.001) from ADG discretionary items were lower in personalised nutrition vs control. There were greater reductions in ADG percentage energy and percentage total fat, SFA and salt for those randomised t

Published
2021

9. The association between vitamin D receptor polymorphisms and tissue-specific insulin resistance in human obesity

Author

Pramono, A, Jocken, J W E, Adriaens, M E, Hjorth, Mads Fiil, Astrup, Arne, Saris, W H M, Blaak, E E, Pramono, A, Jocken, J W E, Adriaens, M E, Hjorth, Mads Fiil, Astrup, Arne, Saris, W H M, and Blaak, E E

Abstract

Background/Objectives: To investigate (1) the association of four VDR polymorphisms (TaqI/rs731236, ApaI/rs7975232, FokI/rs10735810, and Bsml/rs1544410) with markers of adiposity and tissue-specific insulin resistance at baseline, after weight loss and weight maintenance; (2) the effect of the VDR polymorphisms in the SAT transcriptome in overweight/obese Caucasians of the DiOGenes cohort.Methods: We included 553 adult obese individuals (mean BMI 34.8 kg/m2), men (n = 197) and women (n = 356) at baseline, following an 8-week weight loss intervention and 26 weeks weight maintenance. Genotyping was performed using an Illumina 660W-Quad SNP chip on the Illumina iScan Genotyping System. Tissue-specific IR was determined using Hepatic Insulin Resistance Index (HIRI), Muscle Insulin Sensitivity Index (MISI), and Adipose Tissue Insulin Resistance Index (Adipo-IR). Expression quantitative trait loci (eQTL) analysis was performed to determine the effect of SNPs on SAT gene expression.Results: None of the VDR polymorphisms were associated with HIRI or MISI. Interestingly, carriers of the G allele of VDR FokI showed higher Adipo-IR (GG + GA 7.8 ± 0.4 vs. AA 5.6 ± 0.5, P = 0.010) and higher systemic FFA (GG + GA: 637.8 ± 13.4 vs. AA: 547.9 ± 24.7 µmol/L, P = 0.011), even after adjustment with age, sex, center, and FM. However, eQTL analysis showed minor to no effect of these genotypes on the transcriptional level in SAT. Also, VDR polymorphisms were not related to changes in body weight and IR as result of dietary intervention (P > 0.05 for all parameters).Conclusions: The VDR Fokl variant is associated with elevated circulating FFA and Adipo-IR at baseline. Nevertheless, minor to no effect of VDR SNPs on the transcriptional level in SAT, indicating that putative mechanisms of action remain to be determined. Finally, VDR SNPs did not affect dietary intervention outcome in the pr

Published
2021

21. The relationship between circulating acetate and human insulin resistance before and after weight loss in the DiOGenes study

Author

González Hernández, Manuel A, Canfora, Emanuel E, Pasmans, Kenneth, Astrup, Arne, Saris, W H M, Blaak, Ellen E, González Hernández, Manuel A, Canfora, Emanuel E, Pasmans, Kenneth, Astrup, Arne, Saris, W H M, and Blaak, Ellen E

Abstract

Microbially-produced acetate has been reported to beneficially affect metabolic health through effects on satiety, energy expenditure, insulin sensitivity, and substrate utilization. Here, we investigate the association between sex-specific concentrations of acetate and insulin sensitivity/resistance indices (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), circulating insulin and Matsuda Index) in the Diet, Obesity and Genes (DiOGenes) Dietary study at baseline and after a low-calorie diet (LCD, 800 kcal/d). In this analysis, 692 subjects (Body Mass Index >27 kg/m2) were included, who underwent an LCD for 8 weeks. Linear mixed models were performed, which were adjusted for mean acetate concentration, center (random factor), age, weight loss, and fat-free mass (FFM). At baseline, no associations between plasma acetate and insulin sensitivity/resistance indices were found. We found a slight positive association between changes in acetate and changes in HOMA-IR (std 0.130, p = 0.033) in women, but not in men (std -0.072, p = 0.310) independently of age, weight loss and FFM. We were not able to confirm previously reported associations between acetate and insulin sensitivity in this large European cohort. The mechanisms behind the sex-specific relationship between LCD-induced changes in acetate and insulin sensitivity require further study.

Published
2020

41. Voeding bij intensieve sportbeoefening

Author

van Loon, L. J. C., Trommelen, J., van Erp-Baart, A. M. J., and Saris, W. H. M.

Abstract

Voeding is een belangrijke factor die het prestatievermogen van een sporter kan beïnvloeden. Gezien het hoge energiegebruik van een actieve sporter is het belangrijk dat zijn energie-inname gelijke tred houdt met zijn energiegebruik. Behalve aan de hoeveelheid voeding die geconsumeerd moet worden, dient ook aandacht besteed te worden aan de samenstelling. Een juiste verhouding tussen vetten, koolhydraten en eiwitten in de voeding is noodzakelijk. Om prestaties te optimaliseren bestaan gerichte adviezen voor een optimale voeding vóór, tijdens en na inspanning. De kwaliteit van de voeding is eveneens van groot belang, waarbij een adequate aanvoer van vitaminen en mineralen de aandacht behoeft. De vraag of een sporter een verhoogde behoefte heeft aan vitaminen en mineralen is onderwerp van discussie. Aan sommige voedingsstoffen worden – te pas en te onpas – prestatiebevorderende effecten toegeschreven.

Published
2019

45. Abstracts of papers clinical pharmacological meeting

Author

van der Klauw, M. M., Stricker, B. H. Ch., Ottervanger, J. P., van der Meché, F. G. A., van Griensven, J. M. T., Lemkes, H. H. P. J., Kroon, J. M., Schoemaker, H. C., Cohen, A. F., Schellens, J. H. M., Loos, W., van Acker, B., de Boer-Dennert, M., Planting, A. S. T., van der Burg, M. E. L., Stoter, G., Krediet, R., Verweij, J., Blaak, E. E., van Baak, M. A., Kemerink, G. J., Pakbiers, M. T. W., Heidendal, G. A. K., Saris, W. H. M., Bouckaert, S., Vakaet, L., Dhont, M., Remon, J. P., van den Broek, S. A. J., de Graeff, P. A., van Gilst, W. H., van Veldhuisen, D. J., Hillige, H. L., Wesseling, H., Lie, K. I., Gaillard, C. A., van Es, P. N., de Leeuw, P. W., Van Bortel, L. M. A. B., Kool, M. J. F., Lustermans, F. A. T., Breed, J. G. S., Hoeks, A. P. G., Boudier, H. A. J. Struijker, Pickkers, R. P., Smits, P., Baadenhuysen, H., van 't Laar, A., Thien, Th., Elseviers, M. M., De Broe, M. E., van der Ven, A. J. A. M., Koopmans, P. P., Peters, W. H. M., Vree, T. B., van der Meer, J. W. M., Snoeck, E., Van Peer, A., Sack, M., Horton, M., Mannens, G., Woestenborghs, R., Heykants, J., Meibach, R., van Witsen, T. B., Valkenburg, H. A., Vander Stichele, R. H., De Potter, B., Vyncke, P., Bogaert, M. G., Burggraaf, J., Wollersheim, H., van Aalen, J., Schoemaker, R. G., Du, X. Y., Bax, W. A., Bos, E., Saxena, P. R., Rongen, G. A., van Heiningen, P. N. M., Schwietert, H. R., Kortboyer, J. M., Sollie, F. A. E., Piraube, C., Desché, P., Jonkman, J. H. G., Blok, W. L., Gyssens, I. C., Hekster, Y. A., Koopmans, P. P., van der Meer, J. W. M., Jansen P. A. F., Sival R. C., van Nieuwkerk J. F., Klaverwiiden B., de Bruijn, E. A., and Driessen, O.

Published
1993
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