1. Fatty acid-like Pt(IV) prodrugs overcome cisplatin resistance in ovarian cancer by harnessing CD36
- Author
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Zihan Qiu, Amarasooriya M. D. S. Jayawardhana, Morgan Stilgenbauer, Han Wang, Yao-Rong Zheng, Payel Datta, Manabu Kurokawa, Sarine Mckenzie, and David J. Bowers
- Subjects
CD36 Antigens ,endocrine system ,endocrine system diseases ,Organoplatinum Compounds ,CD36 ,Antineoplastic Agents ,010402 general chemistry ,01 natural sciences ,Catalysis ,Cell Line, Tumor ,Materials Chemistry ,medicine ,Humans ,Prodrugs ,chemistry.chemical_classification ,Cisplatin ,Ovarian Neoplasms ,biology ,010405 organic chemistry ,Cisplatin resistance ,Metals and Alloys ,Fatty acid ,Transporter ,General Chemistry ,Prodrug ,medicine.disease ,female genital diseases and pregnancy complications ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,HEK293 Cells ,chemistry ,Chemotherapy Drugs ,Drug Resistance, Neoplasm ,Ceramics and Composites ,biology.protein ,Cancer research ,Female ,Ovarian cancer ,medicine.drug - Abstract
Resistance to the platinum-based chemotherapy drug, cisplatin, is a significant setback in ovarian cancer. We engineered fatty acid-like Pt(IV) prodrugs that harness the fatty acid transporter CD36 to facilitate their entry to ovarian cancer cells. We show that these novel constructs effectively kill cisplatin-resistant ovarian cancer cells.
- Published
- 2020