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10 results on '"Sardiña González, Cristina"'

3. Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study

Author

Muñoz-Gómez, Ana, Fernández-Cruz, Ana, Lavilla-Olleros, Cristina, Giner-Galvañ, Vicente, Ausín-García, Cristina, Wikman, Philip, Bendala-Estrada, Alejandro D., Vargas, Juan A., Rubio-Rivas, Manuel, Laureiro, Jaime, Fernández-Bermúdez, Daniel, Buonaiuto, Verónica A., Larriva, Antonio P. Arenas de, Pascual-Pérez, María de los Reyes, Alcalá-Pedrajas, José N., Ruiz, Ane Labirua-Iturburu, Hernández-Milián, Almudena, Mazo, Marta Gómez del, Antequera, Beatriz, Mella-Pérez, Carmen, Navas-Alcántara, María de la Sierra, Soto-Delgado, Juan F., Gámez-Mancera, Rosa M., Sardiña-González, Cristina, Meijide-Míguez, Héctor, Ramos-Rincón, José M., Gómez-Huelgas, Ricardo, Network, on behalf of the SEMI-COVID-19 Network on behalf of the SEMI-COVID-19, [Muñoz-Gómez,A] Internal Medicine Department, Hospital de Parla, Madrid, Spain. [Fernández-Cruz,A] Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro—Segovia de Arana, Madrid, Spain. [Lavilla-Olleros,C, Ausín-García,C, Bendala-Estrada,AD] Internal Medicine Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Giner-Galvañ,V, Wikman,P] Internal Medicine Department, Hospital Clínico Universitario de Sant Joan d’Alacant, Fundación para el Fomento de la Investigación Sanitaria y Biomédica en la Comunidad Valenciana (FISABIO), Alicante, Spain. [Vargas,JA] Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro—Segovia de Arana, Madrid, Spain. [Rubio-Rivas,M] Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain. [Laureiro,J] Doce de Octubre University Hospital, Madrid, Spain. [Fernández-Bermúdez,D] Internal Medicine Department, Costa del Sol Hospital, Marbella, Spain. [Buonaiuto,VA, and Gómez-Huelgas R] Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), Málaga, Spain. [Arenas de Larriva,AP] Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain. [Arenas de Larriva,AP] CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Pascual-Pérez,MLR] Internal Medicine Department, University General Hospital of Elda, Alicante, Spain. [Alcalá-Pedrajas,JN] Internal Medicine Department, Pozoblanco Regional Hospital, Córdoba, Spain. [Labirua-Iturburu Ruiz,A] Santa Marina Hospital, Bilbao, Spain. [Hernández-Milián,A] Internal Medicine Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. [Gómez Del Mazo,M] Internal Medicine Department, San Pedro Hospital, Logroño, Spain. [Antequera,B] Internal Medicine Department, Sagunto Hospital, Valencia, Spain. [Mella-Pérez,C] Universitary Hospital Complex of Ferrol, A Coruña, Spain. [Navas-Alcántara,MS] Internal Medicine Department, Infanta Margarita Hospital, Cabra, Córdoba, Spain. [Soto-Delgado,JF] Internal Medicine Department, University Hospital of Salamanca, Salamanca, Spain. [Gámez-Mancera,RM] Internal Medicine Department, University Hospital Virgen del Rocío, Sevilla, Spain. [Sardiña-González,C] Internal Medicine Department, Monforte de Lemos Public Hospital, Lugo, Spain. [Meijide-Míguez,H] Internal Medicine Department, Quironsalud Hospital, A Coruña, Spain. [Ramos-Rincón,JM] Department of Clinical Medicine, Miguel Hernandez University of Elche, Alicante, Spain.

Subjects
medicine.medical_specialty, ARDS, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], medicine.medical_treatment, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals [Medical Subject Headings], Article, Steroid, corticosteroids, Estudios retrospectivos, Diseases::Respiratory Tract Diseases::Respiration Disorders::Respiratory Insufficiency [Medical Subject Headings], Internal medicine, medicine, Mortalitat, Mortality, Glucocorticoides, Corticoesteroides, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals [Medical Subject Headings], Chemicals and Drugs::Polycyclic Compounds::Steroids [Medical Subject Headings], business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, General Medicine, medicine.disease, mortality, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Confidence interval, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Propensity Score [Medical Subject Headings], Cortisone, body regions, Pneumonia, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones::Glucocorticoids [Medical Subject Headings], Respiratory failure, Cortisona, Mortalidad, Propensity score matching, Diseases::Respiratory Tract Diseases::Respiration Disorders::Respiratory Distress Syndrome, Adult [Medical Subject Headings], Medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [Medical Subject Headings], business, Glucocorticoid, medicine.drug
Abstract

We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids, and adjusted using a propensity-score for steroid treatment. From March–July 2020, 5.262 (35.26%) were treated with corticosteroids and 9.659 (64.73%) were not. In-hospital mortality overall was 20.50%, it was higher in patients treated with corticosteroids than in controls (28.5% versus 16.2%, OR 2.068 [95% confidence interval, 1.908 to 2.242], p = 0.0001), however, when adjusting by occurrence of ARDS, mortality was significantly lower in the steroid group (43.4% versus 57.6%, OR 0.564 [95% confidence interval, 0.503 to 0.633], p = 0.0001). Moreover, the greater the respiratory failure, the greater the impact on mortality of the steroid treatment. When adjusting these results including the propensity score as a covariate, in-hospital mortality remained significantly lower in the steroid group (OR 0.774 [0.660 to 0.907], p = 0.002). Steroid treatment reduced mortality by 24% relative to no steroid treatment (RRR 0.24). These results support the use of glucocorticoids in COVID-19 in this subgroup of patients.

Published
2021
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4. Role of lupus anticoagulant and von Willebrand factor in chronic reactive endotheliitis in COVID-19

Author

López Reboiro, Manuel Lorenzo, primary, Suárez Fuentetaja, Rebeca, additional, Gutiérrez López, Raquel, additional, Ares Castro-Conde, Beatriz, additional, Sardiña González, Cristina, additional, Navarro Menéndez, Inés, additional, Pereyra Barrionuevo, Marco Francisco, additional, Alves Pérez, M. Teresa, additional, and López Castro, José, additional

Published
2021
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