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2. 2021 Update on Safety of Magnetic Resonance Imaging: Joint Statement From Canadian Cardiovascular Society/Canadian Society for Cardiovascular Magnetic Resonance/Canadian Heart Rhythm Society

Author

Ian Paterson, D., White, James A., Butler, Craig R., Connelly, Kim A., Guerra, Peter G., Hill, Michael D., James, Matthew T., Kirpalani, Anish, Lydell, Carmen P., Roifman, Idan, Sarak, Bradley, Sterns, Laurence D., Verma, Atul, Wan, Douglas, Crean, Andrew M., Grosse-Wortmann, Lars, Hanneman, Kate, Leipsic, Jonathon, Manlucu, Jaimie, Nguyen, Elsie T., Sandhu, Roopinder K., Villemaire, Christine, Wald, Rachel M., and Windram, Jonathan

Published
2021
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6. Biventricular CMR Strain-based Phenotyping for the Prediction of Cardiovascular Outcomes in Cardiac Amyloidosis

Author

Labib, Dina, primary, White, Brooke V, additional, Multani, Asmi, additional, Sarak, Bradley, additional, Dykstra, Steven, additional, Hasanzadeh, Fereshteh, additional, Feng, Yuanchao, additional, MacDonald, Matthew, additional, King, Melanie, additional, Rivest, Sandra, additional, Flewitt, Jacqueline, additional, Howarth, Andrew G., additional, Lydell, Carmen P., additional, Miller, Robert JH, additional, Fine, Nowell M, additional, and White, James A, additional

Published
2024
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7. Comparison of Multi-chamber CMR Phenotype and Clinical Outcomes in ATTR versus AL Cardiac Amyloidosis

Author

Labib, Dina, primary, White, Brooke V, additional, Sarak, Bradley, additional, Multani, Asmi, additional, Dykstra, Steven, additional, Hasanzadeh, Fereshteh, additional, Feng, Yuanchao, additional, MacDonald, Matthew, additional, King, Melanie, additional, Rivest, Sandra, additional, Flewitt, Jacqueline, additional, Howarth, Andrew G., additional, Lydell, Carmen P., additional, Miller, Robert JH, additional, Fine, Nowell M, additional, and White, James, additional

Published
2024
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8. Exploration of Geometric Deep Learning FBom 3D Cardiac Shape Models for the Classification of Cardiac Amyloid Sub-type FBom 2D Cine Cardiovascular Magnetic Resonance Imaging

Author

Marianchuk, Rylan, primary, Dykstra, Steven, additional, Labib, Dina, additional, Ghosh, Tapotosh, additional, Flewitt, Jacqueline, additional, Sarak, Bradley, additional, Rivest, Sandra, additional, Miller, Robert, additional, Fine, Nowell, additional, Maleki, Farhad, additional, and White, James, additional

Published
2024
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16. PREVALENCE AND PROGNOSTIC VALUE OF LATE GADOLINIUM ENHANCEMENT PHENOTYPES IN PATIENTS REFERRED FOR SUSPECTED INFILTRATIVE CARDIOMYOPATHY: AN ANALYSIS OF THE CIROC REGISTRY

Author

Sarak, Bradley, primary, Labib, Dina, additional, Dykstra, Steven, additional, Flewitt, Jackie, additional, Satriano, Alessandro, additional, Rivest, Sandra, additional, Howarth, Andrew G., additional, Lydell, Carmen P., additional, Miller, Robert H., additional, Fine, Nowell M., additional, and White, James, additional

Published
2022
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17. Right Ventricular Mass 12 Years after Osteosarcoma: Multimodality Imaging with Pathologic Correlation

Author

Bannan, Badr, primary, Ismail, Huda S., additional, Alabdulkarim, Faisal M., additional, Sarak, Bradley, additional, Vora, Tushar, additional, Jimenez-Juan, Laura, additional, Gupta, Abha, additional, Yan, Andrew T., additional, Marcuzzi, Danny, additional, Ong, Géraldine, additional, Latter, David A., additional, Nguyen, Elsie T., additional, Seidman, Michael A., additional, Cusimano, Robert J., additional, and Deva, Djeven P., additional

Published
2021
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25. Relationship between changes in blood pressure and left ventricular mass over 1 year in end-stage renal disease

Author

Sarak, Bradley, primary, Wald, Ron, additional, Goldstein, Marc B., additional, Deva, Djeven P., additional, Leipsic, Jonathon, additional, Kiaii, Mercedeh, additional, Leung, General, additional, Barfett, Joseph J., additional, Perl, Jeffrey, additional, Yuen, Darren A., additional, Connelly, Kim A., additional, and Yan, Andrew T., additional

Published
2017
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28. Pulse pressure in acute coronary syndromes: Comparative prognostic significance with systolic blood pressure

Author

Tan, Nigel S, Sarak, Bradley, Fox, Keith AA, Brieger, David, Steg, Ph. Gabriel, Gale, Chris P, Bhatt, Deepak L, Spencer, Frederick A, Grondin, Francois R, Goodman, Shaun G, and Yan, Andrew T

Abstract

Background: Pulse pressure is a readily available vital sign that has been shown to independently predict outcomes in several cardiovascular disease states. We investigated the prognostic significance of pulse pressure (PP) and systolic blood pressure (SBP) among patients with acute coronary syndromes (ACS).Methods: A total of 14,514 patients with ACS in the prospective, multicentre Global Registry of Acute Coronary Events (GRACE), expanded GRACE (GRACE-2) and Canadian Registry of Acute Coronary Events (CANRACE) were stratified by initial PP on presentation. Patient characteristics and in-hospital outcomes were compared by PP quartiles and the independent prognostic significance of PP for in-hospital mortality was quantified. We compared the discriminative ability (c-statistic) of models incorporating either PP or SBP.Results: Patients with higher PPs were older, more frequently female and had higher prevalence rates of conventional cardiovascular risk factors (all p< 0.01). Lower PP was associated with ST-segment elevation myocardial infarction presentation, higher GRACE risk scores and higher rates of adverse in-hospital outcomes (p< 0.001). PP was strongly correlated with SBP (Pearson’s correlation coefficient = 0.79, p< 0.001). After adjustment for other GRACE risk model predictors, lower PP was independently associated with in-hospital mortality (first vs. fourth quartile [reference]: adjusted odds ratio 2.57, 95% confidence interval 1.80–3.67). The c-statistic was slightly higher for the multivariable model incorporating SBP as compared to the model with PP (0.868 vs. 0.864, respectively, p= 0.028) for in-hospital mortality.Conclusion: Higher presenting PP is associated with increased age and more prevalent cardiovascular risk factors, whereas patients with lower PP present with worse clinical characteristics and in-hospital outcomes. Lower PP is an independent adverse prognosticator in ACS. However, PP did not improve the discriminatory performance of the GRACE risk score compared with SBP.

Published
2019
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30. Myocardial Injury Secondary to ICD Shocks: Insights from Patients with Lead Fracture.

Author

SHAM'A, RAED ABU, NERY, PABLO, SADEK, MOUHANNAD, YUNG, DEREK, REDPATH, CALUM, PERRIN, MARK, SARAK, BRADLEY, and BIRNIE, DAVID

Subjects
MYOCARDIUM, ACADEMIC medical centers, ELECTRODES, IMPLANTABLE cardioverter-defibrillators, ARTIFICIAL implants, T-test (Statistics), MEDICAL equipment reliability, DATA analysis software, TROPONIN, DESCRIPTIVE statistics, WOUNDS & injuries
Abstract

Background Patients who receive appropriate implantable cardioverter defibrillator (ICD) shocks have a subsequent adverse prognosis. Most data suggest that patients with inappropriate ICD shocks also have a subsequent adverse prognosis, although this is more controversial. The shocks may be an epiphenomenon, that is, a marker of underlying disease progression; however, it cannot be excluded that shocks cause direct myocardial damage. This latter question is difficult to clarify as the arrhythmia provoking the shock can also cause troponin release. Inappropriate shocks secondary to lead fracture are an ideal situation to examine this question; any troponin release in an otherwise well and hemodynamically stable patient, is likely due directly to the shocks. Methods All patients with Fidelis lead fracture admitted to our institution with inappropriate shocks were included in this study. Troponin (I or T) was considered positive if the level was above the 99th percentile reference cutoff. Results Elevated troponin levels were recorded in 16 of 22 patients (73%). Patients with elevated troponin received a higher number of shocks (20.3 ± 30.1 vs 5.3 ± 4.8, P = 0.07) compared with patients with normal troponin. Very elevated troponin levels (>0.8 mcg/L) were seen in five of 22 (22%) patients. The mean peak troponin level for these five patients was 7.06 ± 8.56 mcg/L; two patients had troponin levels that would be expected from a medium-sized myocardial infarction or severe myocarditis. Conclusion Troponin elevation occurred in the majority of our patients after inappropriate ICD discharges secondary to lead fracture. This indicates that ICD shocks can cause myocardial injury. [ABSTRACT FROM AUTHOR]

Published
2014
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31. Pulse pressure in acute coronary syndromes: Comparative prognostic significance with systolic blood pressure.

Author

Tan NS, Sarak B, Fox KA, Brieger D, Steg PG, Gale CP, Bhatt DL, Spencer FA, Grondin FR, Goodman SG, and Yan AT

Subjects
Acute Coronary Syndrome mortality, Acute Coronary Syndrome physiopathology, Aged, Electrocardiography, Female, Follow-Up Studies, Global Health, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Survival Rate trends, Systole, Time Factors, Acute Coronary Syndrome diagnosis, Blood Pressure physiology, Registries, Risk Assessment methods
Abstract

Background: Pulse pressure is a readily available vital sign that has been shown to independently predict outcomes in several cardiovascular disease states. We investigated the prognostic significance of pulse pressure (PP) and systolic blood pressure (SBP) among patients with acute coronary syndromes (ACS)., Methods: A total of 14,514 patients with ACS in the prospective, multicentre Global Registry of Acute Coronary Events (GRACE), expanded GRACE (GRACE-2) and Canadian Registry of Acute Coronary Events (CANRACE) were stratified by initial PP on presentation. Patient characteristics and in-hospital outcomes were compared by PP quartiles and the independent prognostic significance of PP for in-hospital mortality was quantified. We compared the discriminative ability (c-statistic) of models incorporating either PP or SBP., Results: Patients with higher PPs were older, more frequently female and had higher prevalence rates of conventional cardiovascular risk factors (all p  < 0.01). Lower PP was associated with ST-segment elevation myocardial infarction presentation, higher GRACE risk scores and higher rates of adverse in-hospital outcomes ( p  < 0.001). PP was strongly correlated with SBP (Pearson's correlation coefficient = 0.79, p  < 0.001). After adjustment for other GRACE risk model predictors, lower PP was independently associated with in-hospital mortality (first vs. fourth quartile [reference]: adjusted odds ratio 2.57, 95% confidence interval 1.80-3.67). The c-statistic was slightly higher for the multivariable model incorporating SBP as compared to the model with PP (0.868 vs. 0.864, respectively, p  = 0.028) for in-hospital mortality., Conclusion: Higher presenting PP is associated with increased age and more prevalent cardiovascular risk factors, whereas patients with lower PP present with worse clinical characteristics and in-hospital outcomes. Lower PP is an independent adverse prognosticator in ACS. However, PP did not improve the discriminatory performance of the GRACE risk score compared with SBP.

Published
2019
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