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Backgrouns: Dengue virus infection (DVI) consists of mild-to-severe manifestations. The increasing hematocrit of 20% is used for detecting leakage of plasma, but it is a single parameter that is easily influenced by certain factors. It is necessary to examine the ratio of albumin/globulin which is more stable. The purpose of this study is to find out the ratio of albumin/globulin against various degrees of DVI. Methods: This is an analytic observational study with a cross-sectional and prospective cohort. The study was conducted at the Prof. Dr. R.D. Kandou Hospital, Pancaran Kasih Hospital, and R.W. Monginsidi Hospital from March 2013 to October 2014. The sample is obtained from at least 38 children for each group of DVI. Data were analyzed using SPSS 15, with significant value at p ≤ 0.05. Results: There were 164 children with DVI during the study, but we analyzed only 39 patients with DF, 39 patients with DHF, and 41 patients with DSS. All patients with DF had a albumin/globulin ratio ≥ 1.2, whereas 4 DHF patients and 5 DSS patients had a albumin/globulin ratio ≥ 1,2. Conclusions: There were significant differences in the ratio of albumin/globulin between DF, DHF, and DSS groups. It is emphasized that in the evaluation of plasma leakage using the ratio of albumin/globulin the changing levels of albumin should be considered. We should keep in mind also that there are other factors that can affect the synthesis of albumin.