14 results on '"Sarah S. Goss"'
Search Results
2. Genomics Analysis of L-DOPA Exposure in Drosophila sechellia
- Author
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Serena J. Shimshak, Timothy T. Kim, Sean E. Patterson, Timothy Earley, Ivy Lam, Samuel C. Linde, Stephen M. Lanno, Nola Neri, Mackenzie A. Mitchell, Aashli Budhiraja, Lorencia Chigweshe, Zachary Drum, Keagan P. Collins, Eliza A. Carter, Sara M. Gregory, Angela A. Fan, Eric R. Hagen, Dacheng Zhao, Gregory Ransom, Mariel V. Becker, Sarah B. Hutcheon, Hannah L. Einstein, Kerry E. Brew, Sarah S. Goss, Guadalupe J. Sanchez, Joseph D. Coolon, and Bella M. Wiener
- Subjects
Candidate gene ,esterase ,Genome, Insect ,L-DOPA ,Genomics ,RNA-Seq ,adaptation ,QH426-470 ,Investigations ,Generalist and specialist species ,Drosophila sechellia ,Levodopa ,03 medical and health sciences ,0302 clinical medicine ,Species Specificity ,Gene expression ,Genetics ,Animals ,Molecular Biology ,Gene ,Genetics (clinical) ,030304 developmental biology ,0303 health sciences ,biology ,oogenesis ,fungi ,biology.organism_classification ,Phenotype ,Diet ,Gene Ontology ,Gene Expression Regulation ,Drosophila ,host specialization ,RNA-seq ,Caprylates ,030217 neurology & neurosurgery - Abstract
Drosophila sechellia is a dietary specialist fruit fly that evolved from a generalist ancestor to specialize on the toxic fruit of Morinda citrifolia. This species pair has been the subject of numerous studies where the goal has largely been to determine the genetic basis of adaptations associated with host specialization. Because one of the most striking features of M. citrifolia fruit is the production of toxic volatile compounds that kill insects, most genomic studies in D. sechellia to date have focused on gene expression responses to the toxic compounds in its food. In this study, we aim to identify new genes important for host specialization by profiling gene expression response to 3,4-dihydroxyphenylalanine (L-DOPA). Recent work found it to be highly abundant in M. citrifolia, critical for reproductive success of D. sechellia, and supplementation of diet with the downstream pathway product dopamine can influence toxin resistance phenotypes in related species. Here we used a combination of functional genetics and genomics techniques to identify new genes that are important for D. sechellia ecological adaptation to this new niche. We show that L-DOPA exposure can affect toxin resistance phenotypes, identify genes with plastic responses to L-DOPA exposure, and functionally test an identified candidate gene. We found that knock-down of Esterase 6 (Est6) in a heterologous species alters toxin resistance suggesting Est6 may play an important role in D. sechellia host specialization.
- Published
- 2019
3. Mycobacterium marinum cellulitis: A fishy etiology.
- Author
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Bridwell RE, Newell CF, Inman BL, Goss S, and Long B
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- Humans, Cellulitis etiology, Cellulitis complications, Doxycycline therapeutic use, Anti-Bacterial Agents therapeutic use, Mycobacterium marinum, Mycobacterium Infections, Nontuberculous diagnosis, Mycobacterium Infections, Nontuberculous drug therapy, Mycobacterium Infections, Nontuberculous etiology
- Abstract
Skin and soft tissue infections account for 2% of emergency department visits annually, though more unusual causative bacteria associated with saltwater exposure may result in morbidity. Mycobacterium marinum represents a rare but important cause of cellulitis, which if untreated or improperly managed, can progress to dactylitis or osteomyelitis. This unusual diagnosis is made more challenging due to the prolonged incubation period of approximately 21 days, temporally separating the inoculation from the disease. Patients will present with a nodular rash in a sporotrichoid pattern. While doxycycline is one antibiotic providing saltwater coverage, M. marinum has variable sensitivities to anti-mycobacterial antibiotics, and thus biopsy helps confirm the diagnosis as well as provide sensitivities for treatment. Emergency clinicians should inquire about environmental risk factors when caring for patients with cellulitis, especially with atypical skin presentations, and consider M. marinum as a rare but important cellulitis etiology., (Published by Elsevier Inc.)
- Published
- 2022
- Full Text
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4. Shallow Water Diving-Associated Alveolar Hemorrhage in an Active Duty Sailor: A Case Report.
- Author
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Inman BL, Bridwell RE, Cibrario A, Goss S, and Oliver JJ
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- Adult, Hemorrhage, Humans, Male, Water, Barotrauma complications, Diving adverse effects, Diving injuries, Lung Injury etiology, Military Personnel
- Abstract
Breath-hold diving is a common practice as a part of military dive training. An association between prior lung injury and a propensity for lung barotrauma may have the potential to impact mission readiness for combat divers, Pararescue, Combat Controllers, Army Engineer divers, and various units in Naval Special Warfare and Special Operations. Barotrauma is a common complication of diving, typically occurring at depths greater than 30 m (98.4 ft). Individuals with abnormal lung anatomy or function may be at increased risk of barotrauma at shallower depths than those with healthy lungs, rendering these service members unfit for certain missions. We describe the case of a 25-year-old male, with a remote history of polytrauma and resultant pulmonary pleural adhesions, whose dive training was complicated by lung barotrauma at shallow depths. In missions or training utilizing breath-hold diving, the association with secondary alterations in lung or thoracic anatomy and function may limit which service members can safely participate., (Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
- Published
- 2022
- Full Text
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5. Portal Venous Thrombosis in a Special Operations Paratrooper: A Case Report.
- Author
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Bridwell RE, Clerkin S, Walker NR, Long B, and Goss S
- Subjects
- Humans, Liver Cirrhosis complications, Portal Vein, Venous Thrombosis complications, Venous Thrombosis pathology
- Abstract
Portal vein thrombosis is the thrombotic occlusion of the extrahepatic portal system, which can propagate towards the vena caval system. Although rare, it occurs primarily in those with cirrhosis, intra-abdominal infections, malignancy, or hypercoagulable disorders. This report describes the first reported case of a soldier within special operations without identifiable risk factors who was found to have a completely occlusive portal vein thrombosis after approximately 10 days of insidious abdominal pain. This case emphasizes the importance of considering this rare but dangerous pathology among this highly screened and capable special operations population., (Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
- Published
- 2022
- Full Text
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6. Retropharyngeal Abscess With Severe Airway Compromise Following Anterior Cervical Spine Surgery: A Case Report.
- Author
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Inman BL, Bridwell RE, Larson NP, Goss S, and Oliver J
- Abstract
Anterior cervical corpectomy, discectomy, and fusion are common surgical management options for symptomatic cervical radiculopathy and myelopathy. While these procedures are common and well-tolerated, postoperative complications span from mild dysphasia to airway compromise secondary to retropharyngeal or peri-cervical space abscess. These critical patients require robust airway management, which may entail a multidisciplinary approach or airway management in the operating room. We describe a patient who developed airway compromise 10 days following anterior cervical discectomy and fusion with a pre-platysmal abscess and a large retropharyngeal abscess. These abscesses were large enough to cause a mass effect with tracheal deviation. This deviation was severe enough that the patient required awake incision and drainage prior to rapid sequence intubation., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021, Inman et al.)
- Published
- 2021
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7. Pediatric volvulus induced thyroid storm.
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Bridwell RE, Figlewicz MR, Birdsong S, Goss S, and Belcher CN
- Subjects
- Abdominal Pain etiology, Adolescent, Female, Humans, Intestinal Volvulus physiopathology, Pediatrics methods, Thyroid Crisis physiopathology, Tomography, X-Ray Computed methods, Intestinal Volvulus complications, Thyroid Crisis etiology
- Abstract
Thyroid storm is an unusually rare but life-threatening pediatric occurrence, carrying significant mortality. Skewed towards the adolescent population, thyroid decompensation occurs due to inciting factors ranging from infection, trauma, surgery, burns, medications, direct thyroid trauma, and rarely volvulus. Emergent care focuses on both reversing the inciting event as well as quelling the metabolic hyperactivity associated with thyroid storm. In review of the available literature, this case is the first to date of thyroid storm secondary to malrotation with midgut volvulus in a previously euthyroid adolescent patient., Competing Interests: Declaration of Competing Interest None., (Published by Elsevier Inc.)
- Published
- 2021
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8. A first trimester pregnancy with cerebrovascular accident treated with thrombolytic therapy.
- Author
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Bridwell RE, Werbin AJ, Birdsong S, Goss S, and Long B
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- Abortion, Spontaneous, Female, Humans, Infarction, Middle Cerebral Artery diagnostic imaging, Ischemic Stroke diagnostic imaging, Magnetic Resonance Imaging, Pregnancy, Pregnancy Complications, Cardiovascular diagnostic imaging, Pregnancy Trimester, First, Thrombolytic Therapy, Tomography, X-Ray Computed, Young Adult, Fibrinolytic Agents therapeutic use, Infarction, Middle Cerebral Artery drug therapy, Ischemic Stroke drug therapy, Pregnancy Complications, Cardiovascular drug therapy, Tissue Plasminogen Activator therapeutic use
- Abstract
Pregnant patients are at increased risk of cerebrovascular accident due to the prothrombotic state of pregnancy. This risk is highest in those with pre-eclampsia and eclampsia as well as those of Asian descent. Despite this increased risk, pregnancy was an exclusion criterion for major stroke intervention trials. As a result, there are significant challenges concerning the management of this unique patient population. We describe a case of an early first trimester cerebrovascular accident treated with systemic thrombolysis., (Published by Elsevier Inc.)
- Published
- 2021
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9. A coronavirus disease-2019 induced pancytopenia.
- Author
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Bridwell RE, Inman BL, Birdsong S, Goss S, and Long B
- Subjects
- Acute Kidney Injury therapy, Adult, COVID-19 diagnosis, Continuous Renal Replacement Therapy, Humans, Male, Pancytopenia therapy, Respiration, Artificial, Respiratory Insufficiency therapy, Acute Kidney Injury etiology, COVID-19 complications, Pancytopenia virology, Respiratory Insufficiency etiology, SARS-CoV-2 pathogenicity
- Abstract
As the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) pandemic progresses, various hematologic complications have emerged, often centered around the hypercoagulable state. However, pancytopenia represents a rare but serious complication from SARS-CoV2 infection. While lymphopenia is a common finding, concomitant acute anemia and thrombocytopenia are not commonly reported. We describe a novel case of SARS-CoV2 pancytopenia in a 40-year-old male without active risk factors for cell line derangements but subsequent critical illness., (Published by Elsevier Inc.)
- Published
- 2021
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10. Cornual Pregnancy After Ipsilateral Salpingectomy.
- Author
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Knight CA, Bridwell RE, Long B, and Goss S
- Abstract
Ectopic pregnancy is a serious diagnosis occurring in 1-2% of all pregnancies, causing significant morbidity and mortality if unrecognized. Management of ruptured ectopic pregnancy typically includes salpingectomy, which decreases the risk for repeat ectopic pregnancies. In rare cases after salpingectomy, non-viable implantation may occur on the ipsilateral side of prior surgery. We present a patient with a cornual pregnancy on the ipsilateral side of her prior ectopic pregnancy and salpingectomy., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021, Knight et al.)
- Published
- 2021
- Full Text
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11. Native Mitral Valve Infective Endocarditis From Flossing: A Case Report and Emergency Department Management.
- Author
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Bridwell RE, Larson NP, Birdsong S, Long B, and Goss S
- Abstract
Infective endocarditis (IE) is a rare, elusive disease, carrying a 10%-30% mortality. Requiring a high index of suspicion, IE affects damaged native valves and prosthetic valves. While there are a number of inherent risk factors that predispose patients to IE, dental work in the preceding six weeks is often a culprit of disease, colonizing damaged native mitral valves with Streptococcus viridans species. Traditionally, flossing has been suggested to be protective against IE. We present a case of S. gordonii subacute IE on a regurgitant native mitral valve secondary to vigorous flossing., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2020, Bridwell et al.)
- Published
- 2020
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12. Ebola virus outbreak 2014: clinical review for emergency physicians.
- Author
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Meyers L, Frawley T, Goss S, and Kang C
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- Africa, Western epidemiology, Ebolavirus, Emergency Medicine methods, Hemorrhagic Fever, Ebola epidemiology, Hemorrhagic Fever, Ebola therapy, Humans, United States epidemiology, Disease Outbreaks, Hemorrhagic Fever, Ebola diagnosis
- Abstract
The 2014 Ebola outbreak in West Africa is the largest in history. Ebola viral disease is a severe and fatal illness characterized by a nonspecific viral syndrome followed by fulminant septic shock and coagulopathy. Despite ongoing efforts directed at experimental treatments and vaccine development, current medical management of Ebola viral disease is largely limited to supportive therapy, thus making early case identification and immediate implementation of appropriate control measures critical. Because a case of Ebola viral disease was confirmed in the United States on September 30, 2014, emergency medicine providers should be knowledgeable about it for a number of reasons: we are being called on to answer questions about Ebola and allay public fears, we are likely to be first to encounter an infected patient, and there are increasing numbers of US emergency physicians working in Africa who risk coming in direct contact with the disease. This article seeks to provide emergency physicians with the essential and up-to-date information required to identify, evaluate, and manage Ebola viral disease and to join global efforts to contain the current outbreak., (Copyright © 2014 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
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13. Incidental findings on CT for suspected renal colic in emergency department patients: prevalence and types in 5,383 consecutive examinations.
- Author
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Samim M, Goss S, Luty S, Weinreb J, and Moore C
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- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Comorbidity, Connecticut epidemiology, Emergency Medical Services statistics & numerical data, Female, Humans, Lung Diseases diagnostic imaging, Male, Middle Aged, Pelvic Inflammatory Disease diagnostic imaging, Pelvic Inflammatory Disease epidemiology, Prevalence, Renal Colic diagnostic imaging, Risk Assessment, Sex Distribution, Urolithiasis diagnostic imaging, Young Adult, Emergency Service, Hospital statistics & numerical data, Incidental Findings, Lung Diseases epidemiology, Renal Colic epidemiology, Tomography, X-Ray Computed statistics & numerical data, Urolithiasis epidemiology
- Abstract
Purpose: This study aimed to determine the prevalence, importance, and types of incidental findings (IF) in non-enhanced CT scans performed for suspected renal colic, based on ACR white papers and other accepted radiographic recommendations., Methods: Retrospective review of 5,383 consecutive finalized reports of nonenhanced CT using renal colic protocol performed on adult patients at 2 emergency departments over a 5.5-year period. IF were defined as those unrelated to symptoms (as opposed to alternate causes of symptoms) and were categorized as "important" if follow-up was recommended based on recently published consensus recommendations. Subsets of reports of those with important IF were blindly re-reviewed to calculate inter-rater variability for presence and categorization of important IF., Results: Important IF were identified in 12.7% (95% confidence interval [CI]: 11.8%-13.6%) of scans. Prevalence of important IF increased with age: important IF in individuals age >80 years were 4 times more common than for those aged 18-30 years: 28.9% (95% CI: 22.4%-36.4%) versus 6.9% (95% CI: 5.5%-8.6%), respectively, P ≤ .05. Women had a higher prevalence of important IF compared with men: 13.4% (95% CI: 12.2%-14.7%) versus 11.9% (95% CI: 10.7%-13.2%), but the difference was not statically significant (P = .09). There was substantial inter-rater agreement (kappa ≥ 0.69) regarding presence and classification of important IFs using published guidelines., Conclusions: Important IF occurred in 12.7% of non-enhanced CT scans performed for suspected renal colic in the emergency department and are more common in older individuals. Prospective studies that use radiographic recommendations to characterize IF and examine the outcome and cost of their workup are encouraged., (Copyright © 2015 American College of Radiology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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14. The effects of high-fidelity simulation on salivary cortisol levels in SRNA students: a pilot study.
- Author
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Jones T, Goss S, Weeks B, Miura H, Bassandeh D, and Cheek DJ
- Subjects
- Adult, Female, Humans, Male, Nurse Anesthetists education, Hydrocortisone analysis, Saliva chemistry
- Abstract
The use of clinical simulation in graduate level nursing education provides the opportunity for students to learn and apply theoretical practices of nursing care in a safe and controlled environment. It was postulated that laboratory simulation would mimic the stress levels of a real clinical situation as measured by the stress hormone cortisol. The purpose of this study was to determine whether high-fidelity simulation approximates the stress experienced by nurse anesthesia students in the operating room. Participants (n = 21) were recruited from an accredited nurse anesthesia program in the southern U.S. Saliva was collected for 3 days under controlled conditions for baseline data. Next, saliva was collected for 3 days: the day before, the day of, and the day after simulation. The same process was repeated for the first clinical day in the operating room. The participants acted as their own control. There was a significant (p < 0.05) increase in cortisol levels during laboratory simulation as compared to baseline values. Although levels of cortisol were higher during clinical time than baseline, this increase was not significant (p > 0.05), and levels were lower than levels during simulation. Laboratory simulation of patient scenarios raised the stress hormone cortisol level threefold above baseline levels in nurse anesthesia students, while actual clinical experience did not.
- Published
- 2011
- Full Text
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