1. Reduced fecal short‐chain fatty acids in hispanic children with ulcerative colitis
- Author
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Sarah Rotondo‐Trivette, Beibei Wang, Yihui Luan, Oliver Fiehn, Fengzhu Sun, and Sonia Michail
- Subjects
pediatrics ,short‐chain fatty acids ,ulcerative colitis ,Physiology ,QP1-981 - Abstract
Abstract Background It is known that patients with ulcerative colitis (UC) have reduced numbers of short‐chain fatty acid (SCFA) producing bacteria and reduced SCFA concentration in feces. There is also evidence that Hispanic patients have increased incidence of UC and increased likelihood of developing disease at a younger age. To understand why this might be, we compared fiber intake and fecal SCFA concentrations in Hispanic children with UC and non‐Hispanic children with UC. Methods In this cross‐sectional study conducted at the Children's Hospital of Los Angeles, stool was collected from 22 Hispanic and 31 non‐Hispanic children with UC. SCFAs in the stool were quantified using mass spectrometry. Diet information was collected at the time of stool collection using food frequency questionnaires. Results Acetic acid, butyric acid, isovaleric acid, and propionic acid concentrations are significantly lower in Hispanic children with UC compared to age, gender, and disease activity matched non‐Hispanic children with UC (p
- Published
- 2021
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