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Background: Intimate Partner Violence (IPV) has serious consequences on the mental health of victims-survivors such as Post-Traumatic Stress Disorder (PTSD). « La Maison des Femmes » (MdF, Women’s Home) is a French original medical and social structure specifically dedicated to provide multidisciplinary care for victims-survivors of IPV. The main objective of this study was to examine the prevalence of PTSD in victims-survivors of IPV consulting at the MdF or in two Municipal Health Centers (MHCs) located in the same area of the Paris conurbation. Methods: We conducted an observational survey from July 2020 to June 2021 in the MdF and in two MHCs. All women aged 18 years and over having suffered from IPV were eligible. PTSD diagnosis was assessed using the PTSD self-report checklist of symptoms defined in the DSM-5 (PCL-5). We solicited data on the level of self-rated global health, the substances use, and the possibility of reaching women by phone in the 6 months following the inclusion visit. We also conducted qualitative interviews with a sub-sample of the women, asking for victims-survivors’ perceptions of the effect of the care provided at MdF and perceptions of their specific needs. Results: A total of 67 women (mean age: 34 years old [Standard Deviation=9.7]) responded to our questionnaire (40 in the MdF, 12 in the MHC-1 and 15 in the MHC-2). PTSD diagnosis was retained for 40 women (59.7%) (PCL-5 score ≥33). The prevalence of PTSD was quite similar between the three groups. Around 30% of participants (n=23) self-rated their global health as bad or very bad, less than 30% (n=18) of women were regular smokers. Six months after inclusion, a half of participants (52.2%) had been reached by phone. Analysis of the nine qualitative interviews clarified victims-survivors’ perceptions of the MdF’s specific care: social networking, multidisciplinary approach, specialized listening, healthcare facilities, evasion and “feeling at home”. Conclusions The prevalence of PTSD was high among the three centers. This mixed-methods comparison will serve as a pilot study for a larger comparative trial to assess the impact of the MdF on victims-survivors’ mental health outcomes comparatively with the impact of non-dedicated structures.

Background The evolution of smoking rates according to migrant status has not been examined in France, despite a recent reduction in overall smoking rates. Methods DePICT is a two waves (2016: n = 4356; 2017: n = 4114) nationwide telephone survey, representative of the French adult population. We compared smoking-related behaviors before and after implementation of tobacco-control measures (2017), according to the geographical region of birth. Results Compared to 2016, individuals originating from Africa or the Middle East had a slightly higher smoking prevalence in 2017 (34.7% vs 31.3%), despite a higher intention to quit or attempt in the preceding year (adjusted OR(ORa) = 2.72[1.90; 3.90]) compared to non-immigrants. They were also less likely to experience an unsuccessful quit attempt (ORa = 1.76[1.18; 2.62]). Conclusion Tobacco-control measures could have widened smoking inequalities related to migrant status. The evolution of smoking-related behaviors among immigrants should be examined when studying the long-term effects of such policies.

Background The 2020 COVID-19 pandemic led to a strict lockdown in France from March 17 to May 11, 2020. After the lockdown, the French strategy to mitigate the impact of SARS-CoV-2 relied partly on investigations of all confirmed cases. Monitoring collective settings is particularly important since SARS-CoV-2 seems prone to superspreading events (SSEs). Methods Our study is based on data gathered in Paris from May 11 to December 31, 2020, by the Ile-de-France Regional Health Agency (RHA) to investigate cases occurring in collective and high-risk settings. Specific events in high-risk settings were systematically transmitted to the RHA, and screenings were organized by the facilities, while other settings were reported when three cases were identified within a short period. These settings were more difficult to identify through the surveillance system since no systematic screening was organized by the facility, leaving screenings to rely on the national contact-tracing programme. No official superspreading threshold has been set for SARS-CoV-2. We defined a SSE as an event involving ten cases. Results We analysed 15,706 events associated with 38,670 cases, representing an average of 2.70 cases per event. Most clusters occurred in educational facilities, workplace environments, social care settings, and healthcare facilities. SSEs represented 3.4% but accounted for 28% of all cases reported. The highest number of SSEs occurred in college settings (12.6%), followed by hospitals and retirement homes. Educational facilities had the lowest number of SSEs, with around 1% in preschools and elementary schools. Conclusions We observed different SSE rates in each setting. Preschools and primary schools represented the majority of events but experiencing very few SSEs. Colleges were prone to SSEs and were associated with a high number of secondary cases. These findings provide some insights on contact tracing activities and SARS-CoV-2 transmission in different settings.

Is serum progesterone measurement on the day of embryo transfer associated with outcome of frozen-thawed embryo transfer (FET) in cycles using hormonal replacement therapy (HRT) for endometrium preparation?This single-centre retrospective study assessed the relationship between serum progesterone on embryo transfer day and live birth rates in 227 FET cycles. Endometrial preparation was performed by sequential administration of vaginal oestradiol until endometrial thickness was7 mm, followed by transdermal oestradiol combined with 600 mg vaginal micronized progesterone.Mean serum embryo transfer day progesterone was 11.4 ng/ml. Serum progesterone10 ng/ml was observed in 37% of cycles and was associated with significantly lower pregnancy (34% versus 48%, P= 0.04) and live birth rates (17% versus 31%, P= 0.01). Multivariate logistic regression analysis identified serum embryo transfer day progesterone as a significant prognostic factor for live birth rate (odds ratio [OR]: 2.75, 95% confidence interval [CI]: 1.40-5.43]). Receiver operator curve analysis for live birth rates by serum progesterone levels on embryo transfer day gave an area under the curve of 0.62 (95% CI: 0.53-0.72).The data show that serum progesterone concentration is associated with live birth rate. This outlines the importance of measuring serum progesterone in FET with HRT although progesterone monitoring is not usually performed in routine practice. However, the optimal timing for measurement and further adaptive management in the presence of low values remain to be determined.

International audience; Two cases of confirmed SARS-CoV-2 infection with the B.1.351 variant were reported in France in mid-January, 2020. These cases attended a gathering in Mozambique in mid-December 2020. Investigations led to the identification of five imported cases responsible for 14 transmission chains and a total 36 cases. Epidemiological characteristics seemed comparable to those described before the emergence of the South African variant B.1.351. The lack of tertiary transmission outside of the personal sphere suggests that distancing and barrier measures were effective.