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Whether stored-grain insects can communicate with each other inside stored-grain bulks is an important question for the development of pest management programs. Movements of the individual adults of Cryptolestes ferrugineus towards caged adult(s), in the presence or absence of wheat, were studied inside an apparatus (10 cm length), using an infrared camera. The numbers of the caged adults were 1, 20, or 50 of females or males, and 100 or 200 mixed-sex adults. Without grain, both males and females moved towards the caged single male, but not the caged single female. With grain, neither males nor females moved towards the caged single male or female. When 50 males were added to the cage, females did move significantly towards the caged males. There were trends for introduced males and females to move towards caged males at higher densities.

Bacteria responsive color-changing wound dressings offer a valuable platform for continuous monitoring of the wound bed facilitating early detection of bacterial infections. In this study, we present a highly sensitive electrospun nanofibrous polyurethane wound dressing incorporating a hemicyanine-based chromogenic probe with a labile ester linkage that can be enzymatically cleaved by bacterial lipase released from clinically relevant strains, such as

Background Left atrial appendage occlusion (LAAO) represents a treatment alternative to anticoagulation in patients with atrial fibrillation. We evaluate a novel device for epicardial LAAO in a translational canine model. Methods Nine hounds (n = 9) were used to assess usability, safety, and efficacy of the TigerPaw Pro (TPP) device for epicardial LAAO. Following baseline imaging (intra-cardiac echocardiography (ICE) and angiography) and intraoperative visual inspection, usability was tested via a ``closure/re-opening`` maneuver followed by deployment of a total of twenty TPP devices (n = 20) on the left and right atrial appendages respectively. Procedural safety was evaluated by assessing for adverse-events via direct Epicardial inspection and endocardial imaging. Efficacy evaluation included assessment of device positioning, presence of residual stumps and completeness of closure. Post-mortem evaluation was performed to confirm safety and efficacy. Results Usability testing of all TPP devices was successful (n = 20;100%, delivery-time range 22–120 s) without any procedural adverse-events (tissue damage or tears, bleeding, vessel-impingement, structural impact). All devices fully traversed the ostium (n = 18) or appendage body (n = 2), and conformed smoothly to adjacent cardiac anatomy. In nineteen deployments (n = 19;95%), all device connector pairs were fully engaged, while in one TPP device the most distal pair remained unengaged. ICE and post-mortem inspections revealed complete closure of all appendage ostia (n = 18;100%) and only in one case a small residual stump was detected. Intraoperative safety findings were further confirmed post-mortem. Devices created a nearly smooth line of closure via symmetric endocardial tissue-coaptation. Conclusions In this preclinical model, the TPP demonstrated good ease of use for ostial access, ability to re-position (after engagement) and rapid deployment, while achieving safe and effective LAAO.

Hyperosmolar hyperglycaemic state (HHS) has not previously been reported in cystic fibrosis-related diabetes (CFRD). We report the case of a 15-year old boy with stable CFRD who developed acute HHS after treatment with glucocorticoids and itraconazole for presumed allergic broncho-pulmonary aspergillosis (ABPA). This case highlights the dangerous and preventable combination of high glucose intake, glucocorticoids and itraconazole inhibition of CYP3A4 (with resultant glucocorticoid accumulation) that can result in a state of life- threatening HHS in an adolescent with previously stable CFRD.

As the cost of college attendance continues to rise, it becomes increasingly important for college athletic fundraising organizations to keep up with the rising costs in order to continue to provide critical scholarship support for student-athletes. For many schools, if enough revenue is not generated from private contributions, the threat of cutting sports grows. For this reason, it is important for fundraising organizations to regularly examine the pricing structures in order to most appropriately price their giving levels. No prior research exists that examines how the minimum gift amount for the highest giving level should be determined. The purpose of this study is to determine what market factors may influence this amount by conducting a regression analysis using schools in the Football Bowl Subdivision (FBS) (n = 122). Results of the study suggest that football attendance, men’s basketball winning percentage, number of giving levels, and median income for the metropolitan statistical area are statistically significant in explaining 50% of the variance in minimum gift amount to the highest giving level for the sample (R2=.713). The study produces a model that may be used by schools to gage an appropriate dollar amount for their highest giving level, which may help with pricing the highest giving level more appropriately, creating the potential for increased revenue.

Intravaginal delivery of siRNA for prevention of sexually transmitted infections faces obstacles such as the acidic environment and vaginal mucus barrier. To achieve effective protection and delivery of siRNA, we developed a polysuccinimide (PSI)-based nanocarrier (PSI-PEG-API-PMA, PPAP) by conjugating methoxy polyethylene glycol amine (Me-PEG-NH2, Mw 5000), 1-(3-aminopropyl)imidazole (API), and 1-pyrenemethylamine hydrochloride (PMA) to PSI. PPAP demonstrated a spherical self-assembled nanostructure before and after encapsulation of a model siRNA. Variable electrostatic interaction between API and siRNA at acidic vs. neutral pH accomplished significantly lower burst release at pH 4.2 (4 ± 1%) than pH 7.0 (26 ± 5%) within 1 h. PEGylation enabled siRNA-PPAP to achieve higher mucus penetration efficiency (64 ± 17%) than free siRNA (27 ± 5%) for 24 h. Moreover, in vitro study showed minimal toxicity, successful internalization of siRNA-PPAP in HeLa cells and improved gene knockdown (97.5 ± 0.4%). Overall, PPAP is promising for developing preventative treatments for battling sexually transmitted infections.

Aquatic exercise programs may be a beneficial form of therapy for children and adolescents with cerebral palsy (CP), particularly for those with significant movement limitations where land-based physical activity is difficult. The most recently published systematic review (2005) on aquatic interventions in children with CP found supportive but insufficient evidence on its effectiveness. The aim of this paper is to review recently published literature since 2005 with a focus on aquatic exercise for children with CP. In total, six new studies were published with a main focus on aerobic aquatic interventions in higher functioning children and adolescents with CP. Swimming is one of the most frequently reported physical activities in children and adolescents with CP. Therefore, information on its safety and benefits is highly needed, for those with more severe CP in particular. Research design issues are discussed to help guide future research and practice.

Our poster will describe how Building Healthier and Happier Communities – a national programme, delivered locally – will demonstrate the difference an investment in community capacity makes to managing demand on primary care services. Charities, community groups, social enterprises and voluntary organisations of all shapes and sizes already make significant impacts in areas like early intervention, prevention and care and support for people with complex and multiple conditions but there is scope for them to do more. By shifting resources to build organisations’ capacity, extend their reach and improve their connections, we aim to ensure that more people get the help and support they need without having to visit their GP or other health and social care services. In addition, our programme engages with public sector colleagues to improve their understanding of how the third sector works with people to improve their health and happiness and how, by equipping people to do more for themselves and each other, third sector organisations play an important and ongoing role in building community resilience. Our poster will outline the Scottish commitment to health and social care integration, prevention and co-production; explain how our programme contributes to that change agenda; present our theory of change in the form of a logic model; set out in graphic form the process we have developed for delivering the investment (both direct funding and other forms of support); illustrate our cross-sector partnership approach; and depict the projects which have been selected to receive that support. It will also share some of the key learning points from the project so far.