1. A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer
- Author
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Sarah A. Althubyani, Suliman Y. Al Omar, Afrah F. Alkhuriji, and Manal F. El-Khadragy
- Subjects
Male ,Risk ,Interleukin-27 ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Saudi Arabia ,colorectal cancer ,Single-nucleotide polymorphism ,030204 cardiovascular system & hematology ,Gastroenterology ,polymorphism ,Transforming Growth Factor beta1 ,IL-27 ,03 medical and health sciences ,0302 clinical medicine ,TGFß1 ,Internal medicine ,Genotype ,IL-22 ,medicine ,Humans ,030212 general & internal medicine ,Allele ,Genotyping ,Polymorphism, Genetic ,IL-8 ,business.industry ,Interleukins ,Interleukin-8 ,Case-control study ,General Medicine ,Middle Aged ,medicine.disease ,cytokines ,Interleukin-10 ,Interleukin 10 ,Cytokine ,Case-Control Studies ,IL-10 ,Female ,Original Article ,Colorectal Neoplasms ,business - Abstract
Objective: To determine the possible associations of polymorphisms in interleukin (IL)-8 ( rs4073 T/A), IL-10 ( rs1800896 A/G), IL-22 ( rs1179251 C/G and rs2227485 C/T), IL-27 ( rs17855750 T/G), and transforming growth factor beta 1 (TGFs1) ( rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients. Methods : The case-control study was carried out between July 2019 and January 2020 in King Khaled University Hospital, Riyadh, Saudi Arabia. A total of 70 patients with CRC and 70 healthy controls were included in the study. Single nucleotide polymorphisms of promoter regions were determined using TaqMan genotyping assays. Results: A statistically significant reduction in CRC risk was identified for carriers of the IL-10 ( rs1800896 A/G) AG genotype, IL-22 ( rs1179251 C/G) G allele, IL-27 ( rs17855750 T/G) G allele and TGFs1 ( rs1800469 C/T) CT and TT genotype. While IL-10 ( rs1800896 A/G) AA genotype and TGFs1 ( rs1800469 C/T) CC genotype were significantly associated with increased susceptibility to CRC. No significant associations were identified between the cytokine polymorphisms of IL-8 ( rs4073 T/A) and IL-22 ( rs2227485 C/T), and CRC risk. Conclusion : Our findings indicate a significant impact of IL-10 ( rs1800896 A/G), IL-22 ( rs1179251 C/G), IL-27 ( rs17855750 T/G) and TGF-s1 ( rs1800469 C/T) polymorphisms on risk of CRC; while the IL-8 ( rs4073 T/A) and IL-22 ( rs2227485 C/T) and polymorphisms were not associated with CRC risk. Saudi Med J. 2020 Dec;41(12):1292-1300 doi: 10.15537/smj.2020.12.25543 How to cite this article: Althubyani SA, Alkhuriji AF, Al Omar SY, El-Khadragy MF. A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer. Saudi Med J. 2020 Dec;41(12):1292-1300. doi: 10.15537/smj.2020.12.25543. PMID: 33294886.
- Published
- 2020