1. Pediatric intestinal transplantation
- Author
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Ajai Khanna, Rakesh Sindhi, George V. Mazariegos, Armando Ganoza, Geoff Bond, Sara K. Rassmussen, and Kyle Soltys
- Subjects
Graft Rejection ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,030230 surgery ,Intestinal rehabilitation ,Perioperative Care ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Intestinal failure ,medicine ,Humans ,Child ,education ,Intensive care medicine ,education.field_of_study ,business.industry ,Immunosuppression ,Organ Transplantation ,Surgery ,Intestines ,Transplantation ,Intestinal Diseases ,Treatment Outcome ,Pediatrics, Perinatology and Child Health ,030211 gastroenterology & hepatology ,business ,Immunosuppressive Agents - Abstract
The field of intestinal transplantation has experienced dramatic growth since the first reported cases 3 decades ago. Improvements in operative technique, donor assessment and immunosuppressive protocols have afforded children who suffer from life-threatening complications of intestinal failure a chance at long-term survival. As experience has grown, newer diseases, with more systemic manifestations have arisen as potential indications for transplant. After discussing the historical developments of intestinal transplant as a backdrop, this review focuses on the specific pre-operative indications for transplant as well as the great success that intestinal rehabilitation has witnessed over the past decade. A detailed discussion of evolution of immunosuppressive strategies is followed a general review of the common infectious complications experienced by children after intestinal transplant as well as the current long- and short-term results, including a section on new research on the quality of life in this challenging population of patients.
- Published
- 2017
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