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4 results on '"Saraç, Murat"'

1. Functionalized α‐Fluorinated Amines from Imines and Enol Ethers.

Author

Kyrko, Dimitra, Saraç, Murat, Hao, Jing, Retailleau, Pascal, Ongeri, Sandrine, and Crousse, Benoît

Subjects
*ENOL ethers, *AMINES, *IMINES, *VINYL ethers, *ADDITION reactions, *FLUOROALKYL group, *AMINO alcohols
Abstract

We report the addition reaction of lithium enol ethers to fluoroalkyl imines. A range of different fluoroalkyls and lithiated reagents are well tolerated. Diastereoselective addition of lithium vinyl ethers to fluoroalkyl N‐tert‐butylsulfinylimines is disclosed, providing enantiomerically enriched α‐fluorinated amines in up to 98% yield. This general approach led to the diastereoselective formation of various amino alcohols and amino ethers, which are difficult to obtain by other methods. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Van yüzüncü yıl üniversitesi elektronik belge yönetim sisteminin (EBYS) kullanım memnuniyetinin CART karar ağacı ile incelenmesi

Author

Saraç, Murat, Keskin, Sıddık, and Biyoistatistik Anabilim Dalı

Subjects
Biyoistatistik, Biostatistics
Abstract

Elektronik Belge Yönetim Sistemi (EBYS), kısaca bir kurumdaki belge ve bilgi alış verişinin elektronik ortamda anlık olarak yönetilmesini sağlayan sistem olarak ifade edilebilir. Kurumun en önemli varlığı belge olduğundan, EBYS kurumlar için oldukça önemlidir. Bu nedenle çalışmada, Van Yüzüncü Yıl Üniversitesi, EBYS kullanıcılarının memnuniyet düzeyleri ve bunun ilişkili olabileceği düşünülen bazı kişisel değişkenler arası ilişkinin Sınıflandırma ve regresyon ağacı (CART) yöntemi ile incelenmesi amaçlanmıştır. Çalışmanın verileri, Van Yüzüncü Yıl Üniversitesi'nde çalışan 200 akademik ve idari personele uygulanan anketten elde edilmiştir. Ankette 7 kişisel değişken ile memnuniyeti belirlemeye yönelik, 5'li likert olarak düzenlenmiş 11 ifade yer almıştır. Memnuniyet ifadeleri ile kişisel değişkenler arası ilişki için CART analizi yapılmıştır. CART analizi için belirlenen işlem seçenekleri kullanılarak elde edilen sonuçlara göre; EBYS kullanım memnuniyetine en fazla etki eden değişkenlerin sırasıyla; `EBYS kullanım amacı, EBYS kullanım sıklığı, Meslek, Yaş ve Cinsiyet` değişkenleri olduğu tespit edilmiştir. Hesaplanan algoritmada genel doğruluk oranı %84.5 olarak bulunmuştur. Çapraz geçerlik risk/tahmin değerinin ise %15.5 olduğu gözlenmiştir. Bu çalışmanın, EBYS kullanım memnuniyeti üzerinde etkili olabilecek değişkenleri belirleme, sistemin eksikliklerini giderme ve sistemin etkin çalışmasını sağlama yönünde, düzeltici tedbirlerin alınması bakımından literatüre katkı sağlayabileceği düşünülmektedir. Electronic Document Management System (EDMS) can be expressed briefly as the system that enables instant management of document and information exchange in an institution in electronic environment. Since the most important asset of the institution is the document, EDMS is very important for the institutions. For this reason, it is aimed to investigate the satisfaction levels of EDMS user in Van Yüzüncü Yıl University and to examine relationships between some personal variables that thought to be related with satisfaction by Classification and regression tree (CART) method. The data of the study was obtained from the questionnaire applied to 200 academic and administrative staff working at Van Yüzüncü Yıl University. In the questionnaire, there were 7 personal variables and 11 expressions arranged as 5-point likert for what determine satisfaction with. CART analysis was performed for the relationship between satisfaction expression and personal variables. According to the results obtained by using the transaction options determined for CART analysis; The variables that have the greatest effect on EDMS user satisfaction are; `aim of EDMS usage`, `frequency of EDMS usage`, `Occupation`, `Age` and `Gender` variables. The overall accuracy rate in the calculated algorithm was found to be 84.5%. Cross validation risk / estimate value was observed to be 15.5%. It is concluded that this study may contribute to the literature in order to determine the variables that may have an impact on EDMS usage satisfaction, to eliminate system shortcomings and to ensure effective operation of the system. 59

Published
2020

3. Kentsel dönüşüm ve gelişimi, sosyal boyutu, kentsel dönüşümden doğan hukuki sorunlar

Author

Saraç, Murat, Erzurumluoğlu, Erzan, and Özel Hukuk Anabilim Dalı

Subjects
Hukuk, Compliance with laws, Social dimension, Urban development, Law, Urban transformation
Abstract

Sanayileşme sonrasında yaşanan hızlı iç göç sonucunda kentlerde çarpık yapılaşma ve çöküntü alanları meydana gelmiştir. Çöküntü alanlarının dönüştürülmesi ve yeniden kazanımı kentsel dönüşüm ile mümkündür. Bu çalışmada, kentsel dönüşüm tanımlanmakla birlikte, sosyal ve hukuki boyutları da incelenmiştir. İnceleme dâhilinde kentsel dönüşüm yapılan alanlarda yaşayan kişiler ve dönüşümü gerçekleştiren belediyelerle iletişime geçilerek saha çalışması yapılmıştır. Özellikle 6306 sayılı `Afet Riski Altındaki Alanların Dönüştürülmesi` kanunu incelenmiş ve eksikliklerinin tespit edilmesine de odaklanılmıştır. Kentsel dönüşüm uygulaması yapanların bu çalışmadan faydalanması amaçlanmıştır.Anahtar Kelimeler: Eski Binalar, Kentsel Dönüşüm, Sosyal ve Hukuki Boyut. Because of the fast integral migration that has been aroused after industrialization, unplanned urbanization and depression areas have been occurred in cities. Transformation and retrieval of depression areas is possible with urban transformation. In this study, urban transformation has been defined and its social and juridical aspects have been examined as well. Field work has been done within the examination by establishing communication with people living in the transformation areas and local municipalities which performed the transformation. In this study, especially `The Act on the Transformation of Areas under Disaster Risk numbered 6306` has been examined and it has been focused on the deficiencies of the act as well. It has been aimed for the practitioners of urban transformation to benefit from this study.Keywords: Old Buildings, Urban Transformation, Social and Legal Aspect 187

Published
2014

4. Usefulness of intravenous metoprolol during positive isoproterenol tilt-table test in the choice of treatment for neurocardiogenic syncope.

Author

Baran I, Gemici K, Ozdemir B, Saraç M, Güllülü S, Aydinlar A, and Cordan J

Subjects
Adrenergic beta-Agonists, Adult, Female, Humans, Isoproterenol, Male, Middle Aged, Adrenergic beta-Antagonists therapeutic use, Metoprolol therapeutic use, Syncope, Vasovagal drug therapy, Tilt-Table Test
Abstract

Background: Isoproterenol tilt-table testing provides a diagnosis of neurocardiogenic syncope in patients with syncope or near-syncope. Although acute beta-blockade may prevent the development of syncope during isoproterenol tilt-table testing, the use of beta-blockers for chronic prophylaxis may not be effective for some patients who show a positive response to isoproterenol tilt-table testing. We evaluated whether the efficacy of intravenous metoprolol in preventing symptoms during repeated tests would be helpful in selecting patients suitable for long-term therapy., Methods and Results: We studied 55 patients (35 females, 20 males; mean age 36+/-11 years) who had been chosen from a group referred to our institute with a history of unexplained syncope (> or = 2 syncopal episodes) and a positive response to isoproterenol tilt-table testing. After a positive response to isoproterenol tilt-table testing, 5 mg metoprolol was infused intravenously as a bolus and the test repeated. Thirty-five patients (group 1) showed a positive response again and 20 (group 2) showed a negative response. We started 50 mg metoprolol once a day for patients in group 1 while group 2 was divided into 2 subgroups: the first subgroup (group 2a, 12 patients) was started on 50 mg sertraline or 20 mg paroxetine once a day and the second subgroup (group 2b, 8 patients) was started on 5 mg midodrine orally once a day. Two months later, isoproterenol tilt-table testing was repeated. In group 1, 13 of 35 patients (37%) were positive on isoproterenol tilt-table testing while in group 2, 8 of 20 patients (40%) were positive on isoproterenol tilt-table testing (p not statistically significant). The therapies of the two groups were then interchanged. Two months later (4 months from the beginning of the study), the isoproterenol tilt-table test was repeated. Eleven patients in group 1 (31%) and 6 in group 2 (30%, p not statistically significant) showed a positive response again., Conclusions: We conclude that acute beta-blockade response to positive isoproterenol tilt-table testing is not a useful predictor for the assessment of chronic prophylaxis for neurocardiogenic syncope.

Published
2003

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