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4. Body composition and muscle strength at the end of ICU stay are associated with one-year mortality, a prospective multicenter observational study

Author

Hssain, A. Ait, primary, Farigon, N., additional, Merdji, H., additional, Dominique, G., additional, Bohé, J., additional, Cayot, S., additional, Chabanne, R., additional, Constantin, J.-M., additional, Pereira, B., additional, Bouvier, D., additional, Andant, N., additional, Roth, H., additional, Thibault, R., additional, Sapin, V., additional, Hasselmann, M., additional, Souweine, B., additional, Cano, N., additional, Boirie, Y., additional, and Dupuis, C., additional

Published
2023
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12. Thoracic Epidural Analgesia for Acute Pancreatitis: A Multicenter Randomized Trial

Author

Jabaudon, M., primary, Genevrier, A., additional, Jaber, S., additional, Bühler, L., additional, Bulyez, S., additional, Laterre, P.-F., additional, Escudier, E., additional, Sossou, A., additional, Guerci, P., additional, Bertrand, P.-M., additional, Danin, P.-E., additional, Bonnassieux, M., additional, Windisch, O., additional, Chabanne, R., additional, Godet, T., additional, Roszyk, L., additional, Sapin, V., additional, Heidegger, C.P., additional, Futier, E., additional, Pereira, B., additional, and Constantin, J.-M., additional

Published
2022
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20. NLRP7 Promotes Choriocarcinoma Growth and Progression through the Establishment of an Immunosuppressive Microenvironment

Author

Reynaud, D, Nahed, RA, Lemaitre, N, Bolze, P-A, Traboulsi, W, Sergent, F, Battail, C, Filhol, O, Sapin, V, Boufettal, H, Hoffmann, P, Aboussaouira, T, Murthi, P, Slim, R, Benharouga, M, Alfaidy, N, Reynaud, D, Nahed, RA, Lemaitre, N, Bolze, P-A, Traboulsi, W, Sergent, F, Battail, C, Filhol, O, Sapin, V, Boufettal, H, Hoffmann, P, Aboussaouira, T, Murthi, P, Slim, R, Benharouga, M, and Alfaidy, N

Abstract

The inflammatory gene NLRP7 is the major gene responsible for recurrent complete hydatidiform moles (CHM), an abnormal pregnancy that can develop into gestational choriocarcinoma (CC). However, the role of NLRP7 in the development and immune tolerance of CC has not been investigated. Three approaches were employed to define the role of NLRP7 in CC development: (i) a clinical study that analyzed human placenta and sera collected from women with normal pregnancies, CHM or CC; (ii) an in vitro study that investigated the impact of NLRP7 knockdown on tumor growth and organization; and (iii) an in vivo study that used two CC mouse models, including an orthotopic model. NLRP7 and circulating inflammatory cytokines were upregulated in tumor cells and in CHM and CC. In tumor cells, NLRP7 functions in an inflammasome-independent manner and promoted their proliferation and 3D organization. Gravid mice placentas injected with CC cells invalidated for NLRP7, exhibited higher maternal immune response, developed smaller tumors, and displayed less metastases. Our data characterized the critical role of NLRP7 in CC and provided evidence of its contribution to the development of an immunosuppressive maternal microenvironment that not only downregulates the maternal immune response but also fosters the growth and progression of CC.

Published
2021

28. Correspondence

Author

Gallot, D., Bonnefoy, C., Blanc, P., Coste, K., Delabaere, A., Dechelotte, P., Laurichesse-Delmas, H., Labbe, A., Jacquetin, B., Lemery, D., and Sapin, V.

Published
2011
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29. Prenatal diagnosis of lobar bronchial atresia

Author

Bonnefoy, C., Blanc, P., Coste, K., Delabaere, A., Dechelotte, P. J., Laurichesse-Delmas, H., Labbe, A., Jacquetin, B., Lemery, D., Sapin, V., and Gallot, D.

Published
2011

37. Groupe de travail SFBC « Marqueurs biochimiques de COVID-19 »

Author

Beauvieux, M. C., Bérard, A. M., Aimone-Gastin, I., Barbe, F., Barguil, Y., Collin-Chavagnac, D., Delacour, H., Delevallee, C., Nivet-Antoine, V., Peoc'H, K., Poupon, C., Schmitt, F., Piéroni, L., Sapin, V., CHU Bordeaux [Bordeaux], Centre de résonance magnétique des systèmes biologiques (CRMSB), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre hospitalier territorial Gaston-Bourret [Nouméa], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Gen-Bio [Clermont-Ferrand] (Groupe Inovie ), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Beaujon, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier de Gonesse (CHU Gonesse), Groupe Hospitalier Bretagne Sud (GHBS), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Membres du Groupe de travail SFBC « Marqueurs biochimiques de COVID-19 » Aimone-Gastin Isabelle, Alcaraz Stéphanie, Allouche Stéphane, Balduyck Malika, Barbé Franc¸oise, Barguil Yann, Bastard Jean-Philippe, Beaudeux Jean-Louis, Beauvieux Marie-Christine, Ben Lassoued Amin, Benz de Bretagne Isabelle, Bérard Annie, Bermont Laurent, Bigot-Corbel Edith, Bost Muriel, Bourbonneux Valery, Brunel Valery, Carré Jean-Luc, Chenevier-Gobeaux Camille, Chevrier Marc, Chinetti Giulia, Collin-Chavagnac Delphine, Delacour Hervé, Delevallée Delphine, Desroys du Roure Franc¸ois, Faure Patrice, Galhaud Jean-Philippe, Galinier Anne, Hauet Thierry, Hejl Carine, Jolly Emilie, Kamel Said, Lehmann Sylvain, Leroy Aline, Lessinger Jean-Marc, Levy Pacifique, LorecPenet Anne-Marie, Mesli Samir, Monnet Dagui, Moreau Caroline, Mouly Laurence, Nivet-Antoine Valérie, Oueidat Nathalie, Pecquet Mathieu, Peoc’h Katell, Piéroni Laurence, Poupon Carole, Roubille Martine, Rucheton Benoit, Sakka Medhi, Sapin Vincent, Saunier Vincent, Scherrer Florian, Schmitt Franc¸ois, Zaepfel Sabine, Zozor Samuel Liste des correspondants en biochimie Sous-groupe Privés Boulier Alexandre (Saint-Thibery), Saint Martin Chloé (Saint-Flour), Chatelain Rémi (Roanne), Deleglise Guillaume (Clermont-Ferrand), Froment Pauline (Ganges), Paulus Jean-Marcel (Nancy), Merah Kader (Saint-Denis), Sevin Eric (Limoges), Barrand Lionel (Strasbourg), Boetsch Morgane (Colmar), Lautier Carine (Montpellier), Charrier Frédéric (Arles), Magraff Stéphane (Brumath) Sous-groupe Outre-Mer (OM)/francophonie Cavalier Etienne (CHU Liège), Demar Magali (CH Cayenne), de Guire Vincent et Wang Han Ting (Montréal), Laso Bautista Javier (HFE Cerdagne), Dumas-Chastang Elsa (Papeete, ILM), Outreville Jonathan (Papeete, CHT Mamao), Tayeb Nicole (CH Mayotte), Monde Absalome (CHU Treichville Abidjan), Chiaradia Laura (CH Nouméa), Alomar Yves (CH de St Pierre & Miquelon), Devaud Francois (CH d’Uturoa), Diallo Agne Fatou, Kandji Pape Matar, Gueye Papa Madieye (CHU Fann, Sénégal), Temmar Abdelhakim (CHU de Guadeloupe), Sakandé Jean et Kabré Elie (CHU Yalgado Uuedraogo, Burkina Faso), Padelli Maël (CHU de Martinique), Chabraoui Layachi, pour la Fédération Internationale Francophone de Biologie et Médecine de Laboratoire (FIFBCML), Magny Eric (CHU Réunion) Sous-groupe CH Got Laurence et Francia Thomas (Orléans), Tournoys Marie-Hélène (Béthune), Morvan Cécile (Villefranche), Kadi Habiba (Gonesse), Balluet Rémi (Bourg-en-Bresse), Fissor-Magdelein Cristel (Monaco) Sous-groupe Hôpitaux d’instruction des armées (HIA) Vest Philippe (Clamart), Plantamura Julie (Toulon) Sous-groupe CHU Nord-Est Salignac Sylvain (Nancy), Maboudou Patrice et Onraed Brigitte (Lille), Schneider Nathalie et Szymezak Jean (Reims), Alemann Mathieu, Glady Ludovic, Lavaux Thomas, Kemmel Véronique, Lefevre Paul et Bayer Sophie (Strasbourg), Billoir Paul et Gueudin Marie (Rouen), Grandhomme Frédérique et Gondolf Clémentine (Caen) Sous-groupe CHU Ouest Moal Valérie et Larcher- Joubaud Franc¸oise (Angers), Guery Eve-Anne (Tours), Lefevre Charles, Collet Nicolas et Peltier Lucas (Rennes), Lacape Geneviève, Redonnet-Vernhet Isabelle, Richard Emmanuel et Gilleron Véronique (Bordeaux) Sous-groupe CHU Assistance publique-Hôpitaux de Paris (AP-HP) Czerkiewicz Isabelle (Henri Mondor), Vicca Stéphanie (Necker), Manceau Hanna (Beaujon), Boutten Anne (Bichat) Sous-groupe CHU Sud Ausseil Jérôme (Toulouse), Hamoir Maria, Zemori Laurence, Deconde-Lebutor Célia (Nice), Lamy Anaïs (Nîmes) Sous-groupe CHU Auvergne Rhône-Alpes-Bourgogne Franche-Comté (ARA-BFC) Gambert Ségolène (Dijon), Gonzalo Philippe (Saint-Etienne), Cartier Régine (Lyon), Oris Charlotte (ClermontFerrand), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
History, Professional Practice/organization & administration/standards/trends, SARS-CoV-2, [SDV]Life Sciences [q-bio], Biochemistry/*organization & administration/standards, medical biology, Pneumonia, France/epidemiology, biological markers, 21st Century, Disease Outbreaks, Scientific/*organization & administration/standards, Viral/blood/*diagnosis/epidemiology, covid-19, Community Networks/organization & administration/standards/trends, Coronavirus Infections/blood/*diagnosis/epidemiology, Videoconferencing/organization & administration/standards, Clinical Laboratory Services/*organization & administration/standards, Humans, Betacoronavirus/isolation & purification/pathogenicity, Covid-19, Societies, Pandemics, Biomarkers/*analysis/blood, Intersectoral Collaboration
Abstract

International audience; The SARS-CoV-2 virus is responsible for an epidemic disease called COVID-19, which was initially evidenced in Wuhan, China, and spread very rapidly in China and around the world. In France, the first isolated case seems now to be reported in December 2019, stage 3 of the COVID-19 epidemic was triggered on March 14(th), the start of the planned containment exit from May 11(th). Healthcare services have faced a large influx of patients who may be beyond their capacity to receive and care, particularly in the Large-East and Ile-de-France regions. Some patients show an evolution of the disease never observed before with other coronaviruses and develop in a few days a very important inflammatory reaction, which can lead to death of patients. A working group of the French Society of Clinical Biology (SFBC) was set up with the objective of providing updated information on the current status of the biological prescriptions (focusing on biochemistry ones) and their evolution during the epidemic, and of analyzing the biological parameters associated with comorbidities and patient evolution in order to link biological results with medical events. The expanded working group covers all sectors of medical biology in France and extends to the French-speaking world: hospital sectors (CHU and CH, Army Training Hospitals) and the private sector opening a field of view on the biological situation in establishments for dependent elderly, social establishments and clinical medical institutions. The purpose of this article is the presentation of this working group and its immediate and future actions.; Le virus SARS-CoV-2 est responsable d’une maladie épidémique dénommée COVID-19 initialement mise en évidence à Wuhan (Chine) et qui s’est propagée très rapidement en Chine puis dans le monde entier. En France, le premier cas isolé semble être signalé dès la fin du mois de décembre2019, le stade 3 de l’épidémie a été déclenché le 14 mars 2020 et la sortie progressive du confinement est prévue à partir du 11 mai 2020. Les services de soins ont fait face à un afflux massif de patients pouvant déborder leurs capacités d’accueil et de prise en charge, notamment dans les régions Grand-Est et Ile-de-France. Certains patients présentent une évolution de la maladie encore jamais observée avec les coronavirus et développent en quelques jours une réaction inflammatoire très importante, pouvant mener au décès. Un groupe de travail de la Société française de biologie clinique (SFBC) s’est constitué, ayant pour objectif de faire le point sur les prescriptions biologiques et leur évolution au cours de l’épidémie, d’analyser les paramètres biologiques, avec un focus biochimique, associés aux comorbidités et à l’évolution du patient, dans le but de relier les résultats biologiques avec des évènements du parcours de soins du patient. Ce groupe de travail recouvre tous les secteurs publics (CHU, CH, Hôpitaux d’instruction des armées) et privés de la biologie médicale en France métropolitaine et ultra-marine ; il s’étend également à la francophonie. Il permet une vision large sur la situation biologique en milieu hospitalier, établissements d’hébergements de personnes âgées dépendantes (Ehpad), établissements médicaux sociaux (EMS) et en cliniques. Le but de cet article est la présentation de ce groupe de travail et ses actions immédiates et à venir.

Published
2020
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43. Low fibrosis biomarker levels predict cardiac resynchronization therapy response

Author

Massoullie, G., primary, Sapin, V., additional, Ploux, S., additional, Rossignol, P., additional, Mulliez, A., additional, Jean, F., additional, Marie, P.Y., additional, Merlin, C., additional, Pereira, B., additional, Andronache, M., additional, Motreff, P., additional, Chabin, X., additional, Sellal, J.M., additional, Citron, B., additional, Lusson, J.R., additional, Vorilhon, C., additional, Clerfond, G., additional, Bordachar, P., additional, Zannad, F., additional, and Eschalier, R., additional

Published
2020
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44. Mouse model for bilateral adrenal hyperplasia

Author

Sahut-Barnola, I., De Joussineau, C., Val, P., Lambert-Langlais, S., Lefrançois-Martinez, A.-M., Pointud, J.-C., Marceau, G., Sapin, V., Ragazzon, B., Bertherat, J., Kirschner, L.S., Stratakis, C.A., and Martinez, A.

Published
2009
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45. Low cardiac fibrosis biomarkers levels predict cardiac resynchronization therapy response

Author

Massoullié, G., primary, Sapin, V., additional, Ploux, S., additional, Zannad, F., additional, Mulliez, A., additional, Jean, F., additional, Marie, P.Y., additional, Merlin, C., additional, Pereira, B., additional, Andronnache, M., additional, Motreff, P., additional, Vorilhon, C., additional, Clerfond, G., additional, Rossignol, P., additional, Bordachar, P., additional, and Eschalier, R., additional

Published
2018
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47. Endocrine gland-derived endothelial growth factor (EG-VEGF) is a potential novel regulator of human parturition

Author

Dunand C, Pascale Hoffmann, Sapin V, Blanchon L, Salomon A, Sergent F, Benharouga M, Sabra S, Guibourdenche J, Sj, Lye, Jj, Feige, Alfaidy N, Biologie du Cancer et de l'Infection (BCI - UMR S1036), Commissariat à l'énergie atomique et aux énergies alternatives (CEA) - Institut National de la Santé et de la Recherche Médicale (INSERM), Department Obstetrics and Gynaecology, Grenoble Hospital, Grenoble, France, Universite´ Grenoble-Alpes, Grenoble, France, Laboratoire de Biochimie, Centre Hospitalier Universitaire de Clermont-Ferrand, Retinoids, Development and Developmental Diseases - EA 7281 (R2D2), Université d'Auvergne - Clermont-Ferrand I, Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Commissariat à l'énergie atomique et aux énergies alternatives (CEA) - Centre National de la Recherche Scientifique (CNRS) - Université Grenoble Alpes (UGA), Samuel Lunenfeld Research Institute, University of Toronto - Mount Sinai Hospital, CHU Cochin [APHP], U767 Grossesse normale et pathologique, développement et fonction du placenta et de l'utérus, Institut National de la Santé et de la Recherche Médicale, Biologie du Cancer et de l'Infection (BCI ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CHU Clermont-Ferrand, Retinoids, Development and Developmental Diseases (R2D2), Université d'Auvergne - Clermont-Ferrand I (UdA), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), University of Toronto-Mount Sinai Hospital [Toronto, Canada] (MSH), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Vascular Endothelial Growth Factor A, Receptors, Peptide, Placenta, Pregnancy Trimester, Third, Down-Regulation, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Receptors, G-Protein-Coupled, Tissue Culture Techniques, fetal membranes, mechanism of parturition, Pregnancy, human pregnancy, Humans, Amnion, EG-VEGF, Cells, Cultured, reproductive and urinary physiology, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Labor, Obstetric, Cesarean Section, preterm birth, Chorion, trophoblast, Placentation, Up-Regulation, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Receptors, Vascular Endothelial Growth Factor, Pregnancy Trimester, Second, embryonic structures, Female
Abstract

International audience; EG-VEGF is an angiogenic factor that we identified as a new placental growth factor during human pregnancy. EG-VEGF is also expressed in the mouse fetal membrane (FM) by the end of gestation, suggesting a local role for this protein in the mechanism of parturition. However, injection of EG-VEGF to gravid mice did not induce labor, suggesting a different role for EG-VEGF in parturition. Here, we searched for its role in the FM in relation to human parturition. Human pregnant sera and total FM, chorion, and amnion were collected during the second and third trimesters from preterm no labor, term no labor, and term labor patients. Primary human chorion trophoblast and FM explants cultures were also used. We demonstrate that circulating EG-VEGF increased toward term and significantly decreased at the time of labor. EG-VEGF production was higher in the FM compared to placentas matched for gestational age. Within the FM, the chorion was the main source of EG-VEGF. EG-VEGF receptors, PROKR1 and PROKR2, were differentially expressed within the FM with increased expression toward term and an abrupt decrease with the onset of labor. In chorion trophoblast and FM explants collected from nonlaboring patients, EG-VEGF decreased metalloproteinase-2 and -9 activities and increased PGDH (prostaglandin-metabolizing enzyme) expression. Altogether these data demonstrate that EG-VEGF is a new cytokine that acts locally to ensure FM protection in late pregnancy. Its fine contribution to the initiation of human labor is exhibited by the abrupt decrease in its levels as well as a reduction in its receptors.

Published
2014
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48. Prenatal diagnosis of lobar bronchial atresia

Author

Bonnefoy, C., Blanc, B., Blanc, P., Coste, Karen, Delabaere, A., Dechelotte, P., Dechelotte, P.J., Laurichesse-Delmas, H., Labbé, A., Jacquetin, B., Lemery, D., Sapin, V., Gallot, D., CHU Clermont-Ferrand, Institut de recherches sur la catalyse (IRC), Centre National de la Recherche Scientifique (CNRS), Station d'Expérimentation Régionale sur les Fruits et Légumes (SERFEL), Faculté de Médecine - Clermont-Auvergne (FM - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Génétique, Reproduction et Développement (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Hôtel-Dieu de Clermont-Ferrand, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), coste, karen, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), and SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
Polyhydramnios, medicine.medical_specialty, Pathology, Mediastinal Shift, Bronchi, Prenatal diagnosis, Autopsy, 030204 cardiovascular system & hematology, Young Adult, 03 medical and health sciences, Pulmonary hypoplasia, Fatal Outcome, 0302 clinical medicine, Pregnancy, Prenatal Diagnosis, medicine, Humans, Radiology, Nuclear Medicine and imaging, Ultrasonography, Bronchus, 030219 obstetrics & reproductive medicine, Lung, Radiological and Ultrasound Technology, business.industry, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Obstetrics and Gynecology, General Medicine, respiratory system, medicine.disease, respiratory tract diseases, 3. Good health, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, medicine.anatomical_structure, Reproductive Medicine, Atresia, Female, Radiology, business
Abstract

International audience; We report three cases of fetal lobar bronchial atresia referred to our Fetal Medicine Center during the mid-trimester of pregnancy over the last 15 years. Lobar bronchial atresia can mimic a main stem bronchial atresia on mid-trimester ultrasound examination as it induces extensive lobar enlargement, major mediastinal shift and eversion of the diaphragm. It was associated with severe pulmonary hypoplasia in all three cases, even though polyhydramnios and ascites were absent in two. Termination of pregnancy was performed at parental request after extensive counseling in each of the cases and necropsy confirmed one or two enlarged lung lobes leading to major compression of the remaining lobe(s) of the ipsilateral lung, the contralateral lung and the heart. No other anomalies were observed and the karyotype was normal in all cases.

Published
2010
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