Search

Your search keyword '"Sapey, E"' showing total 307 results
Start Over Author "Sapey, E"
307 results on '"Sapey, E"'

3. Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Author

Raman, Betty, McCracken, Celeste, Cassar, Mark P, Moss, Alastair J, Finnigan, Lucy, Samat, Azlan Helmy A, Ogbole, Godwin, Tunnicliffe, Elizabeth M, Alfaro-Almagro, Fidel, Menke, Ricarda, Xie, Cheng, Gleeson, Fergus, Lukaschuk, Elena, Lamlum, Hanan, McGlynn, Kevin, Popescu, Iulia A, Sanders, Zeena-Britt, Saunders, Laura C, Piechnik, Stefan K, Ferreira, Vanessa M, Nikolaidou, Chrysovalantou, Rahman, Najib M, Ho, Ling-Pei, Harris, Victoria C, Shikotra, Aarti, Singapuri, Amisha, Pfeffer, Paul, Manisty, Charlotte, Kon, Onn M, Beggs, Mark, O'Regan, Declan P, Fuld, Jonathan, Weir-McCall, Jonathan R, Parekh, Dhruv, Steeds, Rick, Poinasamy, Krisnah, Cuthbertson, Dan J, Kemp, Graham J, Semple, Malcolm G, Horsley, Alexander, Miller, Christopher A, O'Brien, Caitlin, Shah, Ajay M, Chiribiri, Amedeo, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish J C, Sereno, Marco, Saunders, Ruth M, Houchen-Wolloff, Linzy, Greening, Neil J, Bolton, Charlotte E, Brown, Jeremy S, Choudhury, Gourab, Diar Bakerly, Nawar, Easom, Nicholas, Echevarria, Carlos, Marks, Michael, Hurst, John R, Jones, Mark G, Wootton, Daniel G, Chalder, Trudie, Davies, Melanie J, De Soyza, Anthony, Geddes, John R, Greenhalf, William, Howard, Luke S, Jacob, Joseph, Man, William D-C, Openshaw, Peter J M, Porter, Joanna C, Rowland, Matthew J, Scott, Janet T, Singh, Sally J, Thomas, David C, Toshner, Mark, Lewis, Keir E, Heaney, Liam G, Harrison, Ewen M, Kerr, Steven, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Sheikh, Aziz, Zheng, Bang, Jenkins, R Gisli, Cox, Eleanor, Francis, Susan, Halling-Brown, Mark, Chalmers, James D, Greenwood, John P, Plein, Sven, Hughes, Paul J C, Thompson, A A Roger, Rowland-Jones, Sarah L, Wild, James M, Kelly, Matthew, Treibel, Thomas A, Bandula, Steven, Aul, Raminder, Miller, Karla, Jezzard, Peter, Smith, Stephen, Nichols, Thomas E, McCann, Gerry P, Evans, Rachael A, Wain, Louise V, Brightling, Christopher E, Neubauer, Stefan, Baillie, J K, Shaw, Alison, Hairsine, Brigid, Kurasz, Claire, Henson, Helen, Armstrong, Lisa, Shenton, Liz, Dobson, H, Dell, Amanda, Lucey, Alice, Price, Andrea, Storrie, Andrew, Pennington, Chris, Price, Claire, Mallison, Georgia, Willis, Gemma, Nassa, Heeah, Haworth, Jill, Hoare, Michaela, Hawkings, Nancy, Fairbairn, Sara, Young, Susan, Walker, S, Jarrold, I, Sanderson, Amy, David, C, Chong-James, K, Zongo, O, James, W Y, Martineau, A, King, Bernie, Armour, C, McAulay, D, Major, E, McGinness, Jade, McGarvey, L, Magee, N, Stone, Roisin, Drain, S, Craig, T, Bolger, A, Haggar, Ahmed, Lloyd, Arwel, Subbe, Christian, Menzies, Daniel, Southern, David, McIvor, Emma, Roberts, K, Manley, R, Whitehead, Victoria, Saxon, W, Bularga, A, Mills, N L, El-Taweel, Hosni, Dawson, Joy, Robinson, Leanne, Saralaya, Dinesh, Regan, Karen, Storton, Kim, Brear, Lucy, Amoils, S, Bermperi, Areti, Elmer, Anne, Ribeiro, Carla, Cruz, Isabel, Taylor, Jessica, Worsley, J, Dempsey, K, Watson, L, Jose, Sherly, Marciniak, S, Parkes, M, McQueen, Alison, Oliver, Catherine, Williams, Jenny, Paradowski, Kerry, Broad, Lauren, Knibbs, Lucy, Haynes, Matthew, Sabit, Ramsey, Milligan, L, Sampson, Claire, Hancock, Alyson, Evenden, Cerys, Lynch, Ceri, Hancock, Kia, Roche, Lisa, Rees, Meryl, Stroud, Natalie, Thomas-Woods, T, Heller, S, Robertson, E, Young, B, Wassall, Helen, Babores, M, Holland, Maureen, Keenan, Natalie, Shashaa, Sharlene, Price, Carly, Beranova, Eva, Ramos, Hazel, Weston, Heather, Deery, Joanne, Austin, Liam, Solly, Reanne, Turney, Sharon, Cosier, Tracey, Hazelton, Tracy, Ralser, M, Wilson, Ann, Pearce, Lorraine, Pugmire, S, Stoker, Wendy, McCormick, W, Dewar, A, Arbane, Gill, Kaltsakas, G, Kerslake, Helen, Rossdale, J, Bisnauthsing, Karen, Aguilar Jimenez, Laura A, Martinez, L M, Ostermann, Marlies, Magtoto, Murphy M, Hart, Nicholas, Marino, Philip, Betts, Sarah, Solano, Teresa S, Arias, Ava Maria, Prabhu, A, Reed, Annabel, Wrey Brown, Caroline, Griffin, Denise, Bevan, Emily, Martin, Jane, Owen, J, Alvarez Corral, Maria, Williams, Nick, Payne, Sheila, Storrar, Will, Layton, Alison, Lawson, Cathy, Mills, Clare, Featherstone, James, Stephenson, Lorraine, Burdett, Tracy, Ellis, Y, Richards, A, Wright, C, Sykes, D L, Brindle, K, Drury, Katie, Holdsworth, L, Crooks, M G, Atkin, Paul, Flockton, Rachel, Thackray-Nocera, Susannah, Mohamed, Abdelrahman, Taylor, Abigail, Perkins, Emma, Ross, Gavin, McGuinness, Heather, Tench, Helen, Phipps, Janet, Loosley, Ronda, Wolf-Roberts, Rebecca, Coetzee, S, Omar, Zohra, Ross, Alexandra, Card, Bethany, Carr, Caitlin, King, Clara, Wood, Chloe, Copeland, D, Calvelo, Ellen, Chilvers, Edwin R, Russell, Emily, Gordon, Hussain, Nunag, Jose Lloyd, Schronce, J, March, Katherine, Samuel, Katherine, Burden, L, Evison, Lynsey, McLeavey, Laura, Orriss-Dib, Lorna, Tarusan, Lawrence, Mariveles, Myril, Roy, Maura, Mohamed, Noura, Simpson, Neil, Yasmin, Najira, Cullinan, P, Daly, Patrick, Haq, Sulaimaan, Moriera, Silvia, Fayzan, Tamanah, Munawar, Unber, Nwanguma, Uchechi, Lingford-Hughes, A, Altmann, Danny, Johnston, D, Mitchell, J, Valabhji, J, Price, L, Molyneaux, P L, Thwaites, Ryan S, Walsh, S, Frankel, A, Lightstone, L, Wilkins, M, Willicombe, M, McAdoo, S, Touyz, R, Guerdette, Anne-Marie, Warwick, Katie, Hewitt, Melanie, Reddy, R, White, Sonia, McMahon, A, Hoare, Amy, Knighton, Abigail, Ramos, Albert, Te, Amelie, Jolley, Caroline J, Speranza, Fabio, Assefa-Kebede, Hosanna, Peralta, Ida, Breeze, Jonathon, Shevket, K, Powell, Natassia, Adeyemi, Oluwaseun, Dulawan, Pearl, Adrego, Rita, Byrne, S, Patale, Sheetal, Hayday, A, Malim, M, Pariante, C, Sharpe, C, Whitney, J, Bramham, K, Ismail, K, Wessely, S, Nicholson, T, Ashworth, Andrew, Humphries, Amy, Tan, Ai Lyn, Whittam, Beverley, Coupland, C, Favager, Clair, Peckham, D, Wade, Elaine, Saalmink, Gwen, Clarke, Jude, Glossop, Jodie, Murira, Jennifer, Rangeley, Jade, Woods, Janet, Hall, Lucy, Dalton, Matthhew, Window, Nicola, Beirne, Paul, Hardy, Tim, Coakley, G, Turtle, Lance, Berridge, Anthony, Cross, Andy, Key, Angela L, Rowe, Anna, Allt, Ann Marie, Mears, Chloe, Malein, Flora, Madzamba, Gladys, Hardwick, H E, Earley, Joanne, Hawkes, Jenny, Pratt, James, Wyles, J, Tripp, K A, Hainey, Kera, Allerton, Lisa, Lavelle-Langham, L, Melling, Lucy, Wajero, Lilian O, Poll, L, Noonan, Matthew J, French, N, Lewis-Burke, N, Williams-Howard, S A, Cooper, Shirley, Kaprowska, Sabina, Dobson, S L, Marsh, Sophie, Highett, Victoria, Shaw, V, Beadsworth, M, Defres, S, Watson, Ekaterina, Tiongson, Gerlynn F, Papineni, Padmasayee, Gurram, Sambasivarao, Diwanji, Shalin N, Quaid, Sheena, Briggs, A, Hastie, Claire, Rogers, Natalie, Stensel, D, Bishop, L, McIvor, K, Rivera-Ortega, P, Al-Sheklly, B, Avram, Cristina, Faluyi, David, Blaikely, J, Piper Hanley, K, Radhakrishnan, K, Buch, M, Hanley, N A, Odell, Natasha, Osbourne, Rebecca, Stockdale, Sue, Felton, T, Gorsuch, T, Hussell, T, Kausar, Zunaira, Kabir, T, McAllister-Williams, H, Paddick, S, Burn, D, Ayoub, A, Greenhalgh, Alan, Sayer, A, Young, A, Price, D, Burns, G, MacGowan, G, Fisher, Helen, Tedd, H, Simpson, J, Jiwa, Kasim, Witham, M, Hogarth, Philip, West, Sophie, Wright, S, McMahon, Michael J, Neill, Paula, Dougherty, Andrew, Morrow, A, Anderson, David, Grieve, D, Bayes, Hannah, Fallon, K, Mangion, K, Gilmour, L, Basu, N, Sykes, R, Berry, C, McInnes, I B, Donaldson, A, Sage, E K, Barrett, Fiona, Welsh, B, Bell, Murdina, Quigley, Jackie, Leitch, Karen, Macliver, L, Patel, Manish, Hamil, R, Deans, Andrew, Furniss, J, Clohisey, S, Elliott, Anne, Solstice, A R, Deas, C, Tee, Caroline, Connell, David, Sutherland, Debbie, George, J, Mohammed, S, Bunker, Jenny, Holmes, Katie, Dipper, A, Morley, Anna, Arnold, David, Adamali, H, Welch, H, Morrison, Leigh, Stadon, Louise, Maskell, Nick, Barratt, Shaney, Dunn, Sarah, Waterson, Samuel, Jayaraman, Bhagy, Light, Tessa, Selby, N, Hosseini, A, Shaw, Karen, Almeida, Paula, Needham, Robert, Thomas, Andrew K, Matthews, Laura, Gupta, Ayushman, Nikolaidis, Athanasios, Dupont, Catherine, Bonnington, J, Chrystal, Melanie, Greenhaff, P L, Linford, S, Prosper, Sabrina, Jang, W, Alamoudi, Asma, Bloss, Angela, Megson, Clare, Nicoll, Debby, Fraser, Emily, Pacpaco, Edmund, Conneh, Florence, Ogg, G, McShane, H, Koychev, Ivan, Chen, Jin, Pimm, John, Ainsworth, Mark, Pavlides, M, Sharpe, M, Havinden-Williams, May, Petousi, Nayia, Talbot, Nick, Carter, Penny, Kurupati, Prathiba, Dong, T, Peng, Yanchun, Burns, A, Kanellakis, N, Korszun, A, Connolly, B, Busby, J, Peto, T, Patel, B, Nolan, C M, Cristiano, Daniele, Walsh, J A, Liyanage, Kamal, Gummadi, Mahitha, Dormand, N, Polgar, Oliver, George, P, Barker, R E, Patel, Suhani, Gibbons, M, Matila, Darwin, Jarvis, Hannah, Lim, Lai, Olaosebikan, Olaoluwa, Ahmad, Shanaz, Brill, Simon, Mandal, S, Laing, C, Michael, Alice, Reddy, A, Johnson, C, Baxendale, H, Parfrey, H, Mackie, J, Newman, J, Pack, Jamie, Parmar, J, Paques, K, Garner, Lucie, Harvey, Alice, Summersgill, C, Holgate, D, Hardy, E, Oxton, J, Pendlebury, Jessica, McMorrow, L, Mairs, N, Majeed, N, Dark, P, Ugwuoke, R, Knight, Sean, Whittaker, S, Strong-Sheldrake, Sophia, Matimba-Mupaya, Wadzanai, Chowienczyk, P, Pattenadk, Dibya, Hurditch, E, Chan, Flora, Carborn, H, Foot, H, Bagshaw, J, Hockridge, J, Sidebottom, J, Lee, Ju Hee, Birchall, K, Turner, Kim, Haslam, L, Holt, L, Milner, L, Begum, M, Marshall, M, Steele, N, Tinker, N, Ravencroft, Phillip, Butcher, Robyn, Misra, S, Coburn, Zach, Fairman, Alexandra, Ford, Amber, Holbourn, Ailsa, Howell, Alice, Lawrie, Allan, Lye, Alison, Mbuyisa, Angeline, Zawia, Amira, Holroyd-Hind, B, Thamu, B, Clark, Cameron, Jarman, Claire, Norman, C, Roddis, C, Foote, David, Lee, Elvina, Ilyas, F, Stephens, G, Newell, Helen, Turton, Helena, Macharia, Irene, Wilson, Imogen, Cole, Joby, McNeill, J, Meiring, J, Rodger, J, Watson, James, Chapman, Kerry, Harrington, Kate, Chetham, Luke, Hesselden, L, Nwafor, Lorenza, Dixon, Myles, Plowright, Megan, Wade, Phillip, Gregory, Rebecca, Lenagh, Rebecca, Stimpson, R, Megson, Sharon, Newman, Tom, Cheng, Yutung, Goodwin, Camelia, Heeley, Cheryl, Sissons, D, Sowter, D, Gregory, Heidi, Wynter, Inez, Hutchinson, John, Kirk, Jill, Bennett, Kaytie, Slack, Katie, Allsop, Lynne, Holloway, Leah, Flynn, Margaret, Gill, Mandy, Greatorex, M, Holmes, Megan, Buckley, Phil, Shelton, Sarah, Turner, Sarah, Sewell, Terri Ann, Whitworth, V, Lovegrove, Wayne, Tomlinson, Johanne, Warburton, Louise, Painter, Sharon, Vickers, Carinna, Redwood, Dawn, Tilley, Jo, Palmer, Sue, Wainwright, Tania, Breen, G, Hotopf, M, Dunleavy, A, Teixeira, J, Ali, Mariam, Mencias, Mark, Msimanga, N, Siddique, Sulman, Samakomva, T, Tavoukjian, Vera, Forton, D, Ahmed, R, Cook, Amanda, Thaivalappil, Favas, Connor, Lynda, Rees, Tabitha, McNarry, M, Williams, N, McCormick, Jacqueline, McIntosh, Jerome, Vere, Joanne, Coulding, Martina, Kilroy, Susan, Turner, Victoria, Butt, Al-Tahoor, Savill, Heather, Fraile, Eva, Ugoji, Jacinta, Landers, G, Lota, Harpreet, Portukhay, Sofiya, Nasseri, Mariam, Daniels, Alison, Hormis, Anil, Ingham, Julie, Zeidan, Lisa, Osborne, Lynn, Chablani, Manish, Banerjee, A, David, A, Pakzad, A, Rangelov, B, Williams, B, Denneny, E, Willoughby, J, Xu, M, Mehta, P, Batterham, R, Bell, R, Aslani, S, Lilaonitkul, W, Checkley, A, Bang, Dongchun, Basire, Donna, Lomas, D, Wall, E, Plant, Hannah, Roy, K, Heightman, M, Lipman, M, Merida Morillas, Marta, Ahwireng, Nyarko, Chambers, R C, Jastrub, Roman, Logan, S, Hillman, T, Botkai, A, Casey, A, Neal, A, Newton-Cox, A, Cooper, B, Atkin, C, McGee, C, Welch, C, Wilson, D, Sapey, E, Qureshi, H, Hazeldine, J, Lord, J M, Nyaboko, J, Short, J, Stockley, J, Dasgin, J, Draxlbauer, K, Isaacs, K, Mcgee, K, Yip, K P, Ratcliffe, L, Bates, M, Ventura, M, Ahmad Haider, N, Gautam, N, Baggott, R, Holden, S, Madathil, S, Walder, S, Yasmin, S, Hiwot, T, Jackson, T, Soulsby, T, Kamwa, V, Peterkin, Z, Suleiman, Z, Chaudhuri, N, Wheeler, H, Djukanovic, R, Samuel, R, Sass, T, Wallis, T, Marshall, B, Childs, C, Marouzet, E, Harvey, M, Fletcher, S, Dickens, C, Beckett, P, Nanda, U, Daynes, E, Charalambou, A, Yousuf, A J, Lea, A, Prickett, A, Gooptu, Bibek, Hargadon, Beverley, Bourne, Charlotte, Christie, C, Edwardson, C, Lee, D, Baldry, E, Stringer, E, Woodhead, F, Mills, G, Arnold, H, Aung, H, Qureshi, I N, Finch, J, Skeemer, J, Hadley, K, Khunti, Kamlesh, Carr, Liesel, Ingram, L, Aljaroof, M, Bakali, M, Bakau, M, Baldwin, M, Bourne, Michelle, Pareek, Manish, Soares, M, Tobin, Martin, Armstrong, Natalie, Brunskill, Nigel, Goodman, N, Cairns, P, Haldar, Pranab, McCourt, P, Dowling, R, Russell, Richard, Diver, Sarah, Edwards, Sarah, Glover, Sarah, Parker, S, Siddiqui, Salman, Ward, T J C, Mcnally, T, Thornton, T, Yates, Tom, Ibrahim, W, Monteiro, Will, Thickett, D, Wilkinson, D, Broome, M, McArdle, P, Upthegrove, R, Wraith, D, Langenberg, C, Summers, C, Bullmore, E, Heeney, J L, Schwaeble, W, Sudlow, C L, Adeloye, D, Newby, D E, Rudan, I, Shankar-Hari, M, Thorpe, M, Pius, R, Walmsley, S, McGovern, A, Ballard, C, Allan, L, Dennis, J, Cavanagh, J, Petrie, J, O'Donnell, K, Spears, M, Sattar, N, MacDonald, S, Guthrie, E, Henderson, M, Guillen Guio, Beatriz, Zhao, Bang, Lawson, C, Overton, Charlotte, Taylor, Chris, Tong, C, Mukaetova-Ladinska, Elizabeta, Turner, E, Pearl, John E, Sargant, J, Wormleighton, J, Bingham, Michelle, Sharma, M, Steiner, Mike, Samani, Nilesh, Novotny, Petr, Free, Rob, Allen, R J, Finney, Selina, Terry, Sarah, Brugha, Terry, Plekhanova, Tatiana, McArdle, A, Vinson, B, Spencer, L G, Reynolds, W, Ashworth, M, Deakin, B, Chinoy, H, Abel, K, Harvie, M, Stanel, S, Rostron, A, Coleman, C, Baguley, D, Hufton, E, Khan, F, Hall, I, Stewart, I, Fabbri, L, Wright, L, Kitterick, P, Morriss, R, Johnson, S, Bates, A, Antoniades, C, Clark, D, Bhui, K, Channon, K M, Motohashi, K, Sigfrid, L, Husain, M, Webster, M, Fu, X, Li, X, Kingham, L, Klenerman, P, Miiler, K, Carson, G, Simons, G, Huneke, N, Calder, P C, Baldwin, D, Bain, S, Lasserson, D, Daines, L, Bright, E, Stern, M, Crisp, P, Dharmagunawardena, R, Reddington, A, Wight, A, Bailey, L, Ashish, A, Robinson, E, Cooper, J, Broadley, A, Turnbull, A, Brookes, C, Sarginson, C, Ionita, D, Redfearn, H, Elliott, K, Barman, L, Griffiths, L, Guy, Z, Gill, Rhyan, Nathu, Rashmita, Harris, Edward, Moss, P, Finnigan, J, Saunders, Kathryn, Saunders, Peter, Kon, S, Kon, Samantha S, O'Brien, Linda, Shah, K, Shah, P, Richardson, Emma, Brown, V, Brown, M, Brown, Jo, Brown, J, Brown, Ammani, Brown, Angela, Choudhury, N, Jones, S, Jones, H, Jones, L, Jones, I, Jones, G, Jones, Heather, Jones, Don, Davies, Ffyon, Davies, Ellie, Davies, Kim, Davies, Gareth, Davies, Gwyneth A, Howard, K, Porter, Julie, Rowland, J, Rowland, A, Scott, Kathryn, Singh, Suver, Singh, Claire, Thomas, S, Thomas, Caradog, Lewis, Victoria, Lewis, J, Lewis, D, Harrison, P, Francis, C, Francis, R, Hughes, Rachel Ann, Hughes, Joan, Hughes, A D, Thompson, T, Kelly, S, Smith, D, Smith, Nikki, Smith, Andrew, Smith, Jacqui, Smith, Laurie, Smith, Susan, Evans, Teriann, Evans, Ranuromanana I, Evans, D, Evans, R, Evans, H, and Evans, J

Published
2023
Full Text
View/download PDF

4. Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study

Author

Jackson, C, Stewart, I D, Plekhanova, T, Cunningham, P S, Hazel, A L, Al-Sheklly, B, Aul, R, Bolton, C E, Chalder, T, Chalmers, J D, Chaudhuri, N, Docherty, A B, Donaldson, G, Edwardson, C L, Elneima, O, Greening, N J, Hanley, N A, Harris, V C, Harrison, E M, Ho, L-P, Houchen-Wolloff, L, Howard, L S, Jolley, C J, Jones, M G, Leavy, O C, Lewis, K E, Lone, N I, Marks, M, McAuley, H J C, McNarry, M A, Patel, B, Piper-Hanley, K, Poinasamy, K, Raman, B, Richardson, M, Rivera-Ortega, P, Rowland-Jones, S L, Rowlands, A V, Saunders, R M, Scott, J T, Sereno, M, Shah, A M, Shikotra, A, Singapuri, A, Stanel, S C, Thorpe, M, Wootton, D G, Yates, T, Jenkins, G, Singh, S J, Man, W D-C, Brightling, C E, Wain, L V, Porter, J C, Thompson, R, Horsley, A, Molyneaux, P L, Evans, R A, Jones, S E, Rutter, M K, Blaikley, J F, Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adrego, R, Aguilar Jimenez, L A, Ahmad, S, Ahmad Haider, N, Ahmed, R, Ahwireng, N, Ainsworth, M, Alamoudi, A, Ali, M, Aljaroof, M, All, AM, Allan, L, Allen, R J, Allerton, L, Allsop, L, Almeida, P, Altmann, D, Alvarez Corral, M, Amoils, S, Anderson, D, Antoniades, C, Arbane, G, Arias, A, Armour, C, Armstrong, L, Armstrong, N, Arnold, D, Arnold, H, Ashish, A, Ashworth, A, Ashworth, M, Aslani, S, Assefa-Kebede, H, Atkin, C, Atkin, P, Aung, H, Austin, L, Avram, C, Ayoub, A, Babores, M, Baggott, R, Bagshaw, J, Baguley, D, Bailey, L, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Baldwin, M, Ballard, C, Banerjee, A, Bang, B, Barker, R E, Barman, L, Barratt, S, Barrett, F, Basire, D, Basu, N, Bates, M, Bates, A, Batterham, R, Baxendale, H, Bayes, H, Beadsworth, M, Beckett, P, Beggs, M, Begum, M, Beirne, P, Bell, D, Bell, R, Bennett, K, Beranova, E, Bermperi, A, Berridge, A, Berry, C, Betts, S, Bevan, E, Bhui, K, Bingham, M, Birchall, K, Bishop, L, Bisnauthsing, K, Blaikely, J, Bloss, A, Bolger, A, Bonnington, J, Botkai, A, Bourne, C, Bourne, M, Bramham, K, Brear, L, Breen, G, Breeze, J, Briggs, A, Bright, E, Brill, S, Brindle, K, Broad, L, Broadley, A, Brookes, C, Broome, M, Brown, A, Brown, J, Brown, J S, Brown, M, Brown, V, Brugha, T, Brunskill, N, Buch, M, Buckley, P, Bularga, A, Bullmore, E, Burden, L, Burdett, T, Burn, D, Burns, G, Burns, A, Busby, J, Butcher, R, Butt, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Carborn, H, Card, B, Carr, C, Carr, L, Carson, G, Carter, P, Casey, A, Cassar, M, Cavanagh, J, Chablani, M, Chambers, R C, Chan, F, Channon, K M, Chapman, K, Charalambou, A, Checkley, A, Chen, J, Cheng, Y, Chetham, L, Childs, C, Chilvers, E R, Chinoy, H, Chiribiri, A, Chong-James, K, Choudhury, G, Choudhury, N, Chowienczyk, P, Christie, C, Chrystal, M, Clark, D, Clark, C, Clarke, J, Clohisey, S, Coakley, G, Coburn, Z, Coetzee, S, Cole, J, Coleman, C, Conneh, F, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Cooper, J, Cooper, S, Copeland, D, Cosier, T, Coulding, M, Coupland, C, Cox, E, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Cuthbertson, D, Daines, L, Dalton, M, Daly, P, Daniels, A, Dark, P, Dasgin, J, David, A, David, C, Davies, E, Davies, F, Davies, G, Davies, G A, Davies, K, Davies, M J, Dawson, J, Daynes, E, De Soyza, A, Deakin, B, Deans, A, Deas, C, Deery, J, Defres, S, Dell, A, Dempsey, K, Denneny, E, Dennis, J, Dewar, A, Dharmagunawardena, R, Diar-Bakerly, N, Dickens, C, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, S L, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Draxlbauer, K, Drury, K, Dulawan, P, Dunleavy, A, Dunn, S, Dupont, C, Earley, J, Easom, N, Echevarria, C, Edwards, S, Edwardson, C, El-Taweel, H, Elliott, A, Elliott, K, Ellis, Y, Elmer, A, Evans, D, Evans, H, Evans, J, Evans, R, Evans, R I, Evans, T, Evenden, C, Evison, L, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Fayzan, T, Featherstone, J, Felton, T, Finch, J, Finney, S, Finnigan, J, Finnigan, L, Fisher, H, Fletcher, S, Flockton, R, Flynn, M, Foot, H, Foote, D, Ford, A, Forton, D, Fraile, E, Francis, C, Francis, R, Francis, S, Frankel, A, Fraser, E, Free, R, French, N, Fu, X, Fuld, J, Furniss, J, Garner, L, Gautam, N, Geddes, J R, George, J, George, P M, Gibbons, M, Gill, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Goodwin, C, Gooptu, B, Gordon, H, Gorsuch, T, Greatorex, M, Greenhaff, P L, Greenhalf, W, Greenhalgh, A, Greenwood, J, Gregory, H, Gregory, R, Grieve, D, Griffin, D, Griffiths, L, Guerdette, A-M, Guillen Guio, B, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Guy, Z, Henson, H, Hadley, K, Haggar, A, Hainey, K, Hairsine, B, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hancock, A, Hancock, K, Haq, S, Hardwick, H E, Hardy, E, Hardy, T, Hargadon, B, Harrington, K, Harris, E, Harrison, P, Hart, N, Harvey, A, Harvey, M, Harvie, M, Haslam, L, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Haynes, M, Hazeldine, J, Hazelton, T, Heaney, L G, Heeley, C, Heeney, J L, Heightman, M, Heller, S, Henderson, M, Hesselden, L, Hewitt, M, Highett, V, Hillman, T, Hiwot, T, Hoare, A, Hoare, M, Hockridge, J, Hogarth, P, Holbourn, A, Holden, S, Holdsworth, L, Holgate, D, Holland, M, Holloway, L, Holmes, K, Holmes, M, Holroyd-Hind, B, Holt, L, Hormis, A, Hosseini, A, Hotopf, M, Howard, K, Howell, A, Hufton, E, Hughes, A D, Hughes, J, Hughes, R, Humphries, A, Huneke, N, Hurditch, E, Hurst, J, Husain, M, Hussell, T, Hutchinson, J, Ibrahim, W, Ilyas, F, Ingham, J, Ingram, L, Ionita, D, Isaacs, K, Ismail, K, Jackson, T, Jacob, J, James, W Y, Jang, W, Jarman, C, Jarrold, I, Jarvis, H, Jastrub, R, Jayaraman, B, Jenkins, R G, Jezzard, P, Jiwa, K, Johnson, C, Johnson, S, Johnston, D, Jones, D, Jones, G, Jones, H, Jones, I, Jones, L, Jones, S, Jose, S, Kabir, T, Kaltsakas, G, Kamwa, V, Kanellakis, N, Kaprowska, S, Kausar, Z, Keenan, N, Kelly, S, Kemp, G, Kerr, S, Kerslake, H, Key, A L, Khan, F, Khunti, K, Kilroy, S, King, B, King, C, Kingham, L, Kirk, J, Kitterick, P, Klenerman, P, Knibbs, L, Knight, S, Knighton, A, Kon, O, Kon, S, Kon, S S, Koprowska, S, Korszun, A, Koychev, I, Kurasz, C, Kurupati, P, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lavelle-Langham, L, Lawrie, A, Lawson, C, Layton, A, Lea, A, Lee, D, Lee, J-H, Lee, E, Leitch, K, Lenagh, R, Lewis, D, Lewis, J, Lewis, V, Lewis-Burke, N, Li, X, Light, T, Lightstone, L, Lilaonitkul, W, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Loosley, R, Lord, J M, Lota, H, Lovegrove, W, Lucey, A, Lukaschuk, E, Lye, A, Lynch, C, MacDonald, S, MacGowan, G, Macharia, I, Mackie, J, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Magtoto, M M, Mairs, N, Majeed, N, Major, E, Malein, F, Malim, M, Mallison, G, Mandal, S, Mangion, K, Manisty, C, Manley, R, March, K, Marciniak, S, Marino, P, Mariveles, M, Marouzet, E, Marsh, S, Marshall, B, Marshall, M, Martin, J, Martineau, A, Martinez, L M, Maskell, N, Matila, D, Matimba-Mupaya, W, Matthews, L, Mbuyisa, A, McAdoo, S, McAllister-Williams, H, McArdle, A, McArdle, P, McAulay, D, McCann, G P, McCormick, J, McCormick, W, McCourt, P, McGarvey, L, McGhee, C, Mcgee, K, McGinness, J, McGlynn, K, McGovern, A, McGuinness, H, McInnes, I B, McIntosh, J, McIvor, E, McIvor, K, McLeavey, L, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McNeill, J, McQueen, A, McShane, H, Mears, C, Megson, C, Megson, S, Mehta, P, Meiring, J, Melling, L, Mencias, M, Menzies, D, Merida Morillas, M, Michael, A, Miller, C, Milligan, L, Mills, C, Mills, G, Mills, N L, Milner, L, Misra, S, Mitchell, J, Mohamed, A, Mohamed, N, Mohammed, S, Monteiro, W, Moriera, S, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A J, Moss, P, Motohashi, K, Msimanga, N, Mukaetova-Ladinska, E, Munawar, U, Murira, J, Nanda, U, Nassa, H, Nasseri, M, Neal, A, Needham, R, Neill, P, Neubauer, S, Newby, D E, Newell, H, Newman, T, Newman, J, Newton-Cox, A, Nicholson, T, Nicoll, D, Nikolaidis, A, Nolan, C M, Noonan, M J, Norman, C, Novotny, P, Nunag, J, Nwafor, L, Nwanguma, U, Nyaboko, J, O'Brien, C, O'Donnell, K, O'Regan, D, O'Brien, L, Odell, N, Ogg, G, Olaosebikan, O, Oliver, C, Omar, Z, Openshaw, P J M, Orriss-Dib, L, Osborne, L, Osbourne, R, Ostermann, M, Overton, C, Owen, J, Oxton, J, Pack, J, Pacpaco, E, Paddick, S, Painter, S, Pakzad, A, Palmer, S, Papineni, P, Paques, K, Paradowski, K, Pareek, M, Parekh, D, Parfrey, H, Pariante, C, Parker, S, Parkes, M, Parmar, J, Patale, S, Patel, M, Patel, S, Pattenadk, D, Pavlides, M, Payne, S, Pearce, L, Pearl, J E, Peckham, D, Pendlebury, J, Peng, Y, Pennington, C, Peralta, I, Perkins, E, Peterkin, Z, Peto, T, Petousi, N, Petrie, J, Pfeffer, P, Phipps, J, Pimm, J, Pius, R, Plant, H, Plein, S, Plowright, M, Polgar, O, Poll, L, Porter, J, Portukhay, S, Powell, N, Prabhu, A, Pratt, J, Price, A, Price, C, Price, D, Price, L, Prickett, A, Propescu, J, Prosper, S, Pugmire, S, Quaid, S, Quigley, J, Quint, J, Qureshi, H, Qureshi, I N, Radhakrishnan, K, Rahman, N M, Ralser, M, Ramos, A, Ramos, H, Rangeley, J, Rangelov, B, Ratcliffe, L, Ravencroft, P, Reddington, A, Reddy, R, Reddy, A, Redfearn, H, Redwood, D, Reed, A, Rees, M, Rees, T, Regan, K, Reynolds, W, Ribeiro, C, Richards, A, Richardson, E, Roberts, K, Robertson, E, Robinson, E, Robinson, L, Roche, L, Roddis, C, Rodger, J, Ross, A, Ross, G, Rossdale, J, Rostron, A, Rowe, A, Rowland, A, Rowland, J, Rowland, M J, Roy, K, Roy, M, Rudan, I, Russell, R, Russell, E, Saalmink, G, Sabit, R, Sage, E K, Samakomva, T, Samani, N, Sampson, C, Samuel, K, Samuel, R, Sanderson, A, Sapey, E, Saralaya, D, Sargent, J, Sarginson, C, Sass, T, Sattar, N, Saunders, K, Saunders, P, Saunders, L C, Savill, H, Saxon, W, Sayer, A, Schronce, J, Schwaeble, W, Scott, K, Selby, N, Semple, M G, Sewell, T A, Shah, K, Shah, P, Shankar-Hari, M, Sharma, M, Sharpe, C, Sharpe, M, Shashaa, S, Shaw, A, Shaw, K, Shaw, V, Sheikh, A, Shelton, S, Shenton, L, Shevket, K, Short, J, Siddique, S, Siddiqui, S, Sidebottom, J, Sigfrid, L, Simons, G, Simpson, J, Simpson, N, Singh, C, Sissons, D, Skeemer, J, Slack, K, Smith, A, Smith, D, Smith, S, Smith, J, Smith, L, Soares, M, Solano, T S, Solly, R, Solstice, A R, Soulsby, T, Southern, D, Sowter, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steele, N, Steiner, M, Stensel, D, Stephens, G, Stephenson, L, Stern, M, Stimpson, R, Stockdale, S, Stockley, J, Stoker, W, Stone, R, Storrar, W, Storrie, A, Storton, K, Stringer, E, Strong-Sheldrake, S, Stroud, N, Subbe, C, Sudlow, C L, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Tarusan, L, Tavoukjian, V, Taylor, A, Taylor, C, Taylor, J, Te, A, Tedd, H, Tee, C J, Teixeira, J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thamu, B, Thickett, D, Thomas, C, Thomas, D C, Thomas, S, Thomas, A K, Thomas-Woods, T, Thompson, T, Thompson, A A R, Thornton, T, Thwaites, R S, Tilley, J, Tinker, N, Tiongson, G F, Tobin, M, Tomlinson, J, Tong, C, Toshner, M, Touyz, R, Tripp, K A, Tunnicliffe, E, Turnbull, A, Turner, E, Turner, S, Turner, V, Turner, K, Turney, S, Turtle, L, Turton, H, Ugoji, J, Ugwuoke, R, Upthegrove, R, Valabhji, J, Ventura, M, Vere, J, Vickers, C, Vinson, B, Wade, E, Wade, P, Wainwright, T, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, J A, Walsh, S, Warburton, L, Ward, T J C, Warwick, K, Wassall, H, Waterson, S, Watson, E, Watson, L, Watson, J, Weir McCall, J, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Weston, H, Wheeler, H, White, S, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Whitworth, V, Wight, A, Wild, J M, Wilkins, M, Wilkinson, D, Williams, B, Williams, N, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Willoughby, J, Wilson, A, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Wood, C, Woodhead, F, Woods, J, Wormleighton, J, Worsley, J, Wraith, D, Wrey Brown, C, Wright, C, Wright, L, Wright, S, Wyles, J, Wynter, I, Xu, M, Yasmin, N, Yasmin, S, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Zawia, A, Zeidan, L, Zhao, B, Zheng, B, Zongo, O, Jackson, Callum, Stewart, Iain D, Plekhanova, Tatiana, Cunningham, Peter S, Hazel, Andrew L, Al-Sheklly, Bashar, Aul, Raminder, Bolton, Charlotte E, Chalder, Trudie, Chalmers, James D, Chaudhuri, Nazia, Docherty, Annemarie B, Donaldson, Gavin, Edwardson, Charlotte L, Elneima, Omer, Greening, Neil J, Hanley, Neil A, Harris, Victoria C, Harrison, Ewen M, Ho, Ling-Pei, Houchen-Wolloff, Linzy, Howard, Luke S, Jolley, Caroline J, Jones, Mark G, Leavy, Olivia C, Lewis, Keir E, Lone, Nazir I, Marks, Michael, McAuley, Hamish J C, McNarry, Melitta A, Patel, Brijesh V, Piper-Hanley, Karen, Poinasamy, Krisnah, Raman, Betty, Richardson, Matthew, Rivera-Ortega, Pilar, Rowland-Jones, Sarah L, Rowlands, Alex V, Saunders, Ruth M, Scott, Janet T, Sereno, Marco, Shah, Ajay M, Shikotra, Aarti, Singapuri, Amisha, Stanel, Stefan C, Thorpe, Mathew, Wootton, Daniel G, Yates, Thomas, Gisli Jenkins, R, Singh, Sally J, Man, William D-C, Brightling, Christopher E, Wain, Louise V, Porter, Joanna C, Thompson, A A Roger, Horsley, Alex, Molyneaux, Philip L, Evans, Rachael A, Jones, Samuel E, Rutter, Martin K, and Blaikley, John F

Published
2023
Full Text
View/download PDF

5. Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

Author

Abel, K., Adamali, H., Adeloye, D., Adeyemi, O., Adrego, R., Aguilar Jimenez, L.A., Ahmad, S., Ahmad Haider, N., Ahmed, R., Ahwireng, N., Ainsworth, M., Al-Sheklly, B., Alamoudi, A., Ali, M., Aljaroof, M., All, A.M., Allan, L., Allen, R.J., Allerton, L., Allsop, L., Almeida, P., Altmann, D., Alvarez Corral, M., Amoils, S., Anderson, D., Antoniades, C., Arbane, G., Arias, A., Armour, C., Armstrong, L., Armstrong, N., Arnold, D., Arnold, H., Ashish, A., Ashworth, A., Ashworth, M., Aslani, S., Assefa-Kebede, H., Atkin, C., Atkin, P., Aul, R., Aung, H., Austin, L., Avram, C., Ayoub, A., Babores, M., Baggott, R., Bagshaw, J., Baguley, D., Bailey, L., Baillie, J.K., Bain, S., Bakali, M., Bakau, M., Baldry, E., Baldwin, D., Baldwin, M., Ballard, C., Banerjee, A., Bang, B., Barker, R.E., Barman, L., Barratt, S., Barrett, F., Basire, D., Basu, N., Bates, M., Bates, A., Batterham, R., Baxendale, H., Bayes, H., Beadsworth, M., Beckett, P., Beggs, M., Begum, M., Beirne, P., Bell, D., Bell, R., Bennett, K., Beranova, E., Bermperi, A., Berridge, A., Berry, C., Betts, S., Bevan, E., Bhui, K., Bingham, M., Birchall, K., Bishop, L., Bisnauthsing, K., Blaikely, J., Bloss, A., Bolger, A., Bolton, C.E., Bonnington, J., Botkai, A., Bourne, C., Bourne, M., Bramham, K., Brear, L., Breen, G., Breeze, J., Briggs, A., Bright, E., Brightling, C.E., Brill, S., Brindle, K., Broad, L., Broadley, A., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J.S., Brown, M., Brown, V., Brugha, T., Brunskill, N., Buch, M., Buckley, P., Bularga, A., Bullmore, E., Burden, L., Burdett, T., Burn, D., Burns, G., Burns, A., Busby, J., Butcher, R., Butt, A., Byrne, S., Cairns, P., Calder, P.C., Calvelo, E., Carborn, H., Card, B., Carr, C., Carr, L., Carson, G., Carter, P., Casey, A., Cassar, M., Cavanagh, J., Chablani, M., Chalder, T., Chalmers, J.D., Chambers, R.C., Chan, F., Channon, K.M., Chapman, K., Charalambou, A., Chaudhuri, N., Checkley, A., Chen, J., Cheng, Y., Chetham, L., Childs, C., Chilvers, E.R., Chinoy, H., Chiribiri, A., Chong-James, K., Choudhury, G., Choudhury, N., Chowienczyk, P., Christie, C., Chrystal, M., Clark, D., Clark, C., Clarke, J., Clohisey, S., Coakley, G., Coburn, Z., Coetzee, S., Cole, J., Coleman, C., Conneh, F., Connell, D., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Copeland, D., Cosier, T., Coulding, M., Coupland, C., Cox, E., Craig, T., Crisp, P., Cristiano, D., Crooks, M.G., Cross, A., Cruz, I., Cullinan, P., Cuthbertson, D., Daines, L., Dalton, M., Daly, P., Daniels, A., Dark, P., Dasgin, J., David, A., David, C., Davies, E., Davies, F., Davies, G., Davies, G.A., Davies, K., Davies, M.J., Dawson, J., Daynes, E., De Soyza, A., Deakin, B., Deans, A., Deas, C., Deery, J., Defres, S., Dell, A., Dempsey, K., Denneny, E., Dennis, J., Dewar, A., Dharmagunawardena, R., Diar-Bakerly, N., Dickens, C., Dipper, A., Diver, S., Diwanji, S.N., Dixon, M., Djukanovic, R., Dobson, H., Dobson, S.L., Docherty, A.B., Donaldson, A., Dong, T., Dormand, N., Dougherty, A., Dowling, R., Drain, S., Draxlbauer, K., Drury, K., drury, H.J.C., Dulawan, P., Dunleavy, A., Dunn, S., Dupont, C., Earley, J., Easom, N., Echevarria, C., Edwards, S., Edwardson, C., El-Taweel, H., Elliott, A., Elliott, K., Ellis, Y., Elmer, A., Elneima, O., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R.A., Evans, R.I., Evans, T., Evenden, C., Evison, L., Fabbri, L., Fairbairn, S., Fairman, A., Fallon, K., Faluyi, D., Favager, C., Fayzan, T., Featherstone, J., Felton, T., Finch, J., Finney, S., Finnigan, J., Finnigan, L., Fisher, H., Fletcher, S., Flockton, R., Flynn, M., Foot, H., Foote, D., Ford, A., Forton, D., Fraile, E., Francis, C., Francis, R., Francis, S., Frankel, A., Fraser, E., Free, R., French, N., Fu, X., Fuld, J., Furniss, J., Garner, L., Gautam, N., Geddes, J.R., George, J., George, P., Gibbons, M., Gill, M., Gilmour, L., Gleeson, F., Glossop, J., Glover, S., Goodman, N., Goodwin, C., Gooptu, B., Gordon, H., Gorsuch, T., Greatorex, M., Greenhaff, P.L., Greenhalf, W., Greenhalgh, A., Greening, N.J., Greenwood, J., Gregory, H., Gregory, R., Grieve, D., Griffin, D., Griffiths, L., Guerdette, A.-M., Guio, B. Guillen, Gummadi, M., Gupta, A., Gurram, S., Guthrie, E., Guy, Z., Henson, H.H., Hadley, K., Haggar, A., Hainey, K., Hairsine, B., Haldar, P., Hall, I., Hall, L., Halling-Brown, M., Hamil, R., Hancock, A., Hancock, K., Hanley, N.A., Haq, S., Hardwick, H.E., Hardy, E., Hardy, T., Hargadon, B., Harrington, K., Harris, E., Harris, V.C., Harrison, E.M., Harrison, P., Hart, N., Harvey, A., Harvey, M., Harvie, M., Haslam, L., Havinden-Williams, M., Hawkes, J., Hawkings, N., Haworth, J., Hayday, A., Haynes, M., Hazeldine, J., Hazelton, T., Heaney, L.G., Heeley, C., Heeney, J.L., Heightman, M., Heller, S., Henderson, M., Hesselden, L., Hewitt, M., Highett, V., Hillman, T., Hiwot, T., Ho, L.P., Hoare, A., Hoare, M., Hockridge, J., Hogarth, P., Holbourn, A., Holden, S., Holdsworth, L., Holgate, D., Holland, M., Holloway, L., Holmes, K., Holmes, M., Holroyd-Hind, B., Holt, L., Hormis, A., Horsley, A., Hosseini, A., Hotopf, M., Houchen-Wolloff, L., Howard, K., Howard, L.S., Howell, A., Hufton, E., Hughes, A.D., Hughes, J., Hughes, R., Humphries, A., Huneke, N., Hurditch, E., Hurst, J., Husain, M., Hussell, T., Hutchinson, J., Ibrahim, W., Ilyas, F., Ingham, J., Ingram, L., Ionita, D., Isaacs, K., Ismail, K., Jackson, T., Jacob, J., James, W.Y., Jang, W., Jarman, C., Jarrold, I., Jarvis, H., Jastrub, R., Jayaraman, B., Jenkins, R.G., Jezzard, P., Jiwa, K., Johnson, C., Johnson, S., Johnston, D., Jolley, C.J., Jones, D., Jones, G., Jones, H., Jones, I., Jones, L., Jones, M.G., Jones, S., Jose, S., Kabir, T., Kaltsakas, G., Kamwa, V., Kanellakis, N., s. Kaprowska, Kausar, Z., Keenan, N., Kelly, S., Kemp, G., Kerr, S., Kerslake, H., Key, A.L., Khan, F., Khunti, K., Kilroy, S., King, B., King, C., Kingham, L., Kirk, J., Kitterick, P., Klenerman, P., Knibbs, L., Knight, S., Knighton, A., Kon, O., Kon, S., Kon, S.S., Koprowska, S., Korszun, A., Koychev, I., Kurasz, C., Kurupati, P., Laing, C., Lamlum, H., Landers, G., Langenberg, C., Lasserson, D., Lavelle-Langham, L., Lawrie, A., Lawson, C., Layton, A., Lea, A., Leavy, O.C., Lee, D., Lee, J.-H., Lee, E., Leitch, K., Lenagh, R., Lewis, D., Lewis, J., Lewis, K.E., Lewis, V., Lewis-Burke, N., Li, X., Light, T., Lightstone, L., Lilaonitkul, W., Lim, L., Linford, S., Lingford-Hughes, A., Lipman, M., Liyanage, K., Lloyd, A., Logan, S., Lomas, D., Lone, N.I., Loosley, R., Lord, J.M., Lota, H., Lovegrove, W., Lucey, A., Lukaschuk, E., Lye, A., Lynch, C., MacDonald, S., MacGowan, G., Macharia, I., Mackie, J., Macliver, L., Madathil, S., Madzamba, G., Magee, N., Magtoto, M.M., Mairs, N., Majeed, N., Major, E., Malein, F., Malim, M., Mallison, G., D-C. Man, W., Mandal, S., Mangion, K., Manisty, C., Manley, R., March, K., Marciniak, S., Marino, P., Mariveles, M., Marks, M., Marouzet, E., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martineau, A., Martinez, L.M., Maskell, N., Matila, D., Matimba-Mupaya, W., Matthews, L., Mbuyisa, A., McAdoo, S., McAllister-Williams, H., McArdle, A., McArdle, P., McAulay, D., McCann, G.P., McCormick, J., McCormick, W., McCourt, P., McGarvey, L., McGee, C., Mcgee, K., McGinness, J., McGlynn, K., McGovern, A., McGuinness, H., McInnes, I.B., McIntosh, J., McIvor, E., McIvor, K., McLeavey, L., McMahon, A., McMahon, M.J., McMorrow, L., Mcnally, T., McNarry, M., McNeill, J., McQueen, A., McShane, H., Mears, C., Megson, C., Megson, S., Mehta, P., Meiring, J., Melling, L., Mencias, M., Menzies, D., Merida Morillas, M., Michael, A., Miller, C., Milligan, L., Mills, C., Mills, G., Mills, N.L., Milner, L., Misra, S., Mitchell, J., Mohamed, A., Mohamed, N., Mohammed, S., Molyneaux, P.L., Monteiro, W., Moriera, S., Morley, A., Morrison, L., Morriss, R., Morrow, A., Moss, A.J., Moss, P., Motohashi, K., Msimanga, N., Mukaetova-Ladinska, E., Munawar, U., Murira, J., Nanda, U., Nassa, H., Nasseri, M., Neal, A., Needham, R., Neill, P., Neubauer, S., Newby, D.E., Newell, H., Newman, T., Newman, J., Newton-Cox, A., Nicholson, T., Nicoll, D., Nikolaidis, A., Nolan, C.M., Noonan, M.J., Norman, C., Novotny, P., Nunag, J., Nwafor, L., Nwanguma, U., Nyaboko, J., O'Brien, C., O'Donnell, K., O'Regan, D., O'Brien, L., Odell, N., Ogg, G., Olaosebikan, O., Oliver, C., Omar, Z., Openshaw, P.J.M., Orriss-Dib, L., Osborne, L., Osbourne, R., Ostermann, M., Overton, C., Owen, J., Oxton, J., Pack, J., Pacpaco, E., Paddick, S., Painter, S., Pakzad, A., Palmer, S., Papineni, P., Paques, K., Paradowski, K., Pareek, M., Parekh, D., Parfrey, H., Pariante, C., Parker, S., Parkes, M., Parmar, J., Patale, S., Patel, B., Patel, M., Patel, S., Pattenadk, D., Pavlides, M., Payne, S., Pearce, L., Pearl, J.E., Peckham, D., Pendlebury, J., Peng, Y., Pennington, C., Peralta, I., Perkins, E., Peterkin, Z., Peto, T., Petousi, N., Petrie, J., Pfeffer, P., Phipps, J., Pimm, J., Hanley, K. Piper, Pius, R., Plant, H., Plein, S., Plekhanova, T., Plowright, M., Poinasamy, K., Polgar, O., Poll, L., Porter, J.C., Porter, J., Portukhay, S., Powell, N., Prabhu, A., Pratt, J., Price, A., Price, C., Price, D., Price, L., Prickett, A., Propescu, J., Prosper, S., Pugmire, S., Quaid, S., Quigley, J., Quint, J., Qureshi, H., Qureshi, I.N., Radhakrishnan, K., Rahman, N.M., Ralser, M., Raman, B., Ramos, A., Ramos, H., Rangeley, J., Rangelov, B., Ratcliffe, L., Ravencroft, P., Reddington, A., Reddy, R., Reddy, A., Redfearn, H., Redwood, D., Reed, A., Rees, M., Rees, T., Regan, K., Reynolds, W., Ribeiro, C., Richards, A., Richardson, E., Richardson, M., Rivera-Ortega, P., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Roche, L., Roddis, C., Rodger, J., Ross, A., Ross, G., Rossdale, J., Rostron, A., Rowe, A., Rowland, A., Rowland, J., Rowland, M.J., Rowland-Jones, S.L., Roy, K., Roy, M., Rudan, I., Russell, R., Russell, E., Saalmink, G., Sabit, R., Sage, E.K., Samakomva, T., Samani, N., Sampson, C., Samuel, K., Samuel, R., Sanderson, A., Sapey, E., Saralaya, D., Sargant, J., Sarginson, C., Sass, T., Sattar, N., Saunders, K., Saunders, R.M., Saunders, P., Saunders, L.C., Savill, H., Saxon, W., Sayer, A., Schronce, J., Schwaeble, W., Scott, J.T., Scott, K., Selby, N., Semple, M.G., Sereno, M., Sewell, T.A., Shah, A., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Sharpe, M., Shashaa, S., Shaw, A., Shaw, K., Shaw, V., Sheikh, A., Shelton, S., Shenton, L., Shevket, K., Shikotra, A., Short, J., Siddique, S., Siddiqui, S., Sidebottom, J., Sigfrid, L., Simons, G., Simpson, J., Simpson, N., Singapuri, A., Singh, C., Singh, S., Singh, S.J., Sissons, D., Skeemer, J., Slack, K., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Soares, M., Solano, T.S., Solly, R., Solstice, A.R., Soulsby, T., Southern, D., Sowter, D., Spears, M., Spencer, L.G., Speranza, F., Stadon, L., Stanel, S., Steele, N., Steiner, M., Stensel, D., Stephens, G., Stephenson, L., Stern, M., Stewart, I., Stimpson, R., Stockdale, S., Stockley, J., Stoker, W., Stone, R., Storrar, W., Storrie, A., Storton, K., Stringer, E., Strong-Sheldrake, S., Stroud, N., Subbe, C., Sudlow, C.L., Suleiman, Z., Summers, C., Summersgill, C., Sutherland, D., Sykes, D.L., Sykes, R., Talbot, N., Tan, A.L., Tarusan, L., Tavoukjian, V., Taylor, A., Taylor, C., Taylor, J., Te, A., Tedd, H., Tee, C.J., Teixeira, J., Tench, H., Terry, S., Thackray-Nocera, S., Thaivalappil, F., Thamu, B., Thickett, D., Thomas, C., Thomas, D.C., Thomas, S., Thomas, A.K., Thomas-Woods, T., Thompson, T., Thompson, A.A.R., Thornton, T., Thorpe, M., Thwaites, R.S., Tilley, J., Tinker, N., Tiongson, G.F., Tobin, M., Tomlinson, J., Tong, C., Toshner, M., Touyz, R., Tripp, K.A., Tunnicliffe, E., Turnbull, A., Turner, E., Turner, S., Turner, V., Turner, K., Turney, S., Turtle, L., Turton, H., Ugoji, J., Ugwuoke, R., Upthegrove, R., Valabhji, J., Ventura, M., Vere, J., Vickers, C., Vinson, B., Wade, E., Wade, P., Wain, L.V., Wainwright, T., Wajero, L.O., Walder, S., Walker, S., Wall, E., Wallis, T., Walmsley, S., Walsh, J.A., Walsh, S., Warburton, L., Ward, T.J.C., Warwick, K., Wassall, H., Waterson, S., Watson, E., Watson, L., Watson, J., McCall, J. Weir, Welch, C., Welch, H., Welsh, B., Wessely, S., West, S., Weston, H., Wheeler, H., White, S., Whitehead, V., Whitney, J., Whittaker, S., Whittam, B., Whitworth, V., Wight, A., Wild, J., Wilkins, M., Wilkinson, D., Williams, B., Williams, N., Williams, J., Williams-Howard, S.A., Willicombe, M., Willis, G., Willoughby, J., Wilson, A., Wilson, D., Wilson, I., Window, N., Witham, M., Wolf-Roberts, R., Wood, C., Woodhead, F., Woods, J., Wootton, D.G., Wormleighton, J., Worsley, J., Wraith, D., Brown, C. Wrey, Wright, C., Wright, L., Wright, S., Wyles, J., Wynter, I., Xu, M., Yasmin, N., Yasmin, S., Yates, T., Yip, K.P., Young, B., Young, S., Young, A., Yousuf, A.J., Zawia, A., Zeidan, L., Zhao, B., Zheng, B., Zongo, O., Zheng, Bang, Vivaldi, Giulia, Daines, Luke, Leavy, Olivia C., Richardson, Matthew, Elneima, Omer, McAuley, Hamish J.C., Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M., Harris, Victoria C., Houchen-Wolloff, Linzy, Greening, Neil J., Pfeffer, Paul E., Hurst, John R., Brown, Jeremy S., Shankar-Hari, Manu, Echevarria, Carlos, De Soyza, Anthony, Harrison, Ewen M., Docherty, Annemarie B., Lone, Nazir, Quint, Jennifer K., Chalmers, James D., Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krishna, Raman, Betty, Heaney, Liam G., Wain, Louise V., Evans, Rachael A., Brightling, Christopher E., Martineau, Adrian, and Sheikh, Aziz

Published
2023
Full Text
View/download PDF

6. Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

Author

Abel, K., Adamali, H., Adeloye, D., Adeyemi, O., Adrego, R., Aguilar Jimenez, L.A., Ahmad, S., Ahmad Haider, N., Ahmed, R., Ahwireng, N., Ainsworth, M., Al-Sheklly, B., Alamoudi, A., Ali, M., Aljaroof, M., All, A.M., Allan, L., Allen, R.J., Allerton, L., Allsop, L., Almeida, P., Altmann, D., Alvarez Corral, M., Amoils, S., Anderson, D., Antoniades, C., Arbane, G., Arias, A., Armour, C., Armstrong, L., Armstrong, N., Arnold, D., Arnold, H., Ashish, A., Ashworth, A., Ashworth, M., Aslani, S., Assefa-Kebede, H., Atkin, C., Atkin, P., Aul, R., Aung, H., Austin, L., Avram, C., Ayoub, A., Babores, M., Baggott, R., Bagshaw, J., Baguley, D., Bailey, L., Baillie, J.K., Bain, S., Bakali, M., Bakau, M., Baldry, E., Baldwin, D., Baldwin, M., Ballard, C., Banerjee, A., Bang, B., Barker, R.E., Barman, L., Barratt, S., Barrett, F., Basire, D., Basu, N., Bates, M., Bates, A., Batterham, R., Baxendale, H., Bayes, H., Beadsworth, M., Beckett, P., Beggs, M., Begum, M., Beirne, P., Bell, D., Bell, R., Bennett, K., Beranova, E., Bermperi, A., Berridge, A., Berry, C., Betts, S., Bevan, E., Bhui, K., Bingham, M., Birchall, K., Bishop, L., Bisnauthsing, K., Blaikely, J., Bloss, A., Bolger, A., Bolton, C.E., Bonnington, J., Botkai, A., Bourne, C., Bourne, M., Bramham, K., Brear, L., Breen, G., Breeze, J., Briggs, A., Bright, E., Brightling, C.E., Brill, S., Brindle, K., Broad, L., Broadley, A., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J.S., Brown, M., Brown, V., Brugha, T., Brunskill, N., Buch, M., Buckley, P., Bularga, A., Bullmore, E., Burden, L., Burdett, T., Burn, D., Burns, G., Burns, A., Busby, J., Butcher, R., Butt, A., Byrne, S., Cairns, P., Calder, P.C., Calvelo, E., Carborn, H., Card, B., Carr, C., Carr, L., Carson, G., Carter, P., Casey, A., Cassar, M., Cavanagh, J., Chablani, M., Chalder, T., Chalmers, J.D., Chambers, R.C., Chan, F., Channon, K.M., Chapman, K., Charalambou, A., Chaudhuri, N., Checkley, A., Chen, J., Cheng, Y., Chetham, L., Childs, C., Chilvers, E.R., Chinoy, H., Chiribiri, A., Chong-James, K., Choudhury, G., Choudhury, N., Chowienczyk, P., Christie, C., Chrystal, M., Clark, D., Clark, C., Clarke, J., Clohisey, S., Coakley, G., Coburn, Z., Coetzee, S., Cole, J., Coleman, C., Conneh, F., Connell, D., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Copeland, D., Cosier, T., Coulding, M., Coupland, C., Cox, E., Craig, T., Crisp, P., Cristiano, D., Crooks, M.G., Cross, A., Cruz, I., Cullinan, P., Cuthbertson, D., Daines, L., Dalton, M., Daly, P., Daniels, A., Dark, P., Dasgin, J., David, A., David, C., Davies, E., Davies, F., Davies, G., Davies, G.A., Davies, K., Davies, M.J., Dawson, J., Daynes, E., De Soyza, A., Deakin, B., Deans, A., Deas, C., Deery, J., Defres, S., Dell, A., Dempsey, K., Denneny, E., Dennis, J., Dewar, A., Dharmagunawardena, R., Diar-Bakerly, N., Dickens, C., Dipper, A., Diver, S., Diwanji, S.N., Dixon, M., Djukanovic, R., Dobson, H., Dobson, S.L., Docherty, A.B., Donaldson, A., Dong, T., Dormand, N., Dougherty, A., Dowling, R., Drain, S., Draxlbauer, K., Drury, K., Drury, H.J.C., Dulawan, P., Dunleavy, A., Dunn, S., Dupont, C., Earley, J., Easom, N., Echevarria, C., Edwards, S., Edwardson, C., El-Taweel, H., Elliott, A., Elliott, K., Ellis, Y., Elmer, A., Elneima, O., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R.A., Evans, R.I., Evans, T., Evenden, C., Evison, L., Fabbri, L., Fairbairn, S., Fairman, A., Fallon, K., Faluyi, D., Favager, C., Fayzan, T., Featherstone, J., Felton, T., Finch, J., Finney, S., Finnigan, J., Finnigan, L., Fisher, H., Fletcher, S., Flockton, R., Flynn, M., Foot, H., Foote, D., Ford, A., Forton, D., Fraile, E., Francis, C., Francis, R., Francis, S., Frankel, A., Fraser, E., Free, R., French, N., Fu, X., Fuld, J., Furniss, J., Garner, L., Gautam, N., Geddes, J.R., George, J., George, P., Gibbons, M., Gill, M., Gilmour, L., Gleeson, F., Glossop, J., Glover, S., Goodman, N., Goodwin, C., Gooptu, B., Gordon, H., Gorsuch, T., Greatorex, M., Greenhaff, P.L., Greenhalf, W., Greenhalgh, A., Greening, N.J., Greenwood, J., Gregory, H., Gregory, R., Grieve, D., Griffin, D., Griffiths, L., Guerdette, A.-M., Guillen Guio, B., Gummadi, M., Gupta, A., Gurram, S., Guthrie, E., Guy, Z., Henson, H.H., Hadley, K., Haggar, A., Hainey, K., Hairsine, B., Haldar, P., Hall, I., Hall, L., Halling-Brown, M., Hamil, R., Hancock, A., Hancock, K., Hanley, N.A., Haq, S., Hardwick, H.E., Hardy, E., Hardy, T., Hargadon, B., Harrington, K., Harris, E., Harris, V.C., Harrison, E.M., Harrison, P., Hart, N., Harvey, A., Harvey, M., Harvie, M., Haslam, L., Havinden-Williams, M., Hawkes, J., Hawkings, N., Haworth, J., Hayday, A., Haynes, M., Hazeldine, J., Hazelton, T., Heaney, L.G., Heeley, C., Heeney, J.L., Heightman, M., Heller, S., Henderson, M., Hesselden, L., Hewitt, M., Highett, V., Hillman, T., Hiwot, T., Ho, L.P., Hoare, A., Hoare, M., Hockridge, J., Hogarth, P., Holbourn, A., Holden, S., Holdsworth, L., Holgate, D., Holland, M., Holloway, L., Holmes, K., Holmes, M., Holroyd-Hind, B., Holt, L., Hormis, A., Horsley, A., Hosseini, A., Hotopf, M., Houchen-Wolloff, L., Howard, K., Howard, L.S., Howell, A., Hufton, E., Hughes, A.D., Hughes, J., Hughes, R., Humphries, A., Huneke, N., Hurditch, E., Hurst, J., Husain, M., Hussell, T., Hutchinson, J., Ibrahim, W., Ilyas, F., Ingham, J., Ingram, L., Ionita, D., Isaacs, K., Ismail, K., Jackson, T., Jacob, J., James, W.Y., Jang, W., Jarman, C., Jarrold, I., Jarvis, H., Jastrub, R., Jayaraman, B., Jenkins, R.G., Jezzard, P., Jiwa, K., Johnson, C., Johnson, S., Johnston, D., Jolley, C.J., Jones, D., Jones, G., Jones, H., Jones, I., Jones, L., Jones, M.G., Jones, S., Jose, S., Kabir, T., Kaltsakas, G., Kamwa, V., Kanellakis, N., Kaprowska, S., Kausar, Z., Keenan, N., Kelly, S., Kemp, G., Kerr, S., Kerslake, H., Key, A.L., Khan, F., Khunti, K., Kilroy, S., King, B., King, C., Kingham, L., Kirk, J., Kitterick, P., Klenerman, P., Knibbs, L., Knight, S., Knighton, A., Kon, O., Kon, S., Kon, S.S., Koprowska, S., Korszun, A., Koychev, I., Kurasz, C., Kurupati, P., Laing, C., Lamlum, H., Landers, G., Langenberg, C., Lasserson, D., Lavelle-Langham, L., Lawrie, A., Lawson, C., Layton, A., Lea, A., Leavy, O.C., Lee, D., Lee, J.-H., Lee, E., Leitch, K., Lenagh, R., Lewis, D., Lewis, J., Lewis, K.E., Lewis, V., Lewis-Burke, N., Li, X., Light, T., Lightstone, L., Lilaonitkul, W., Lim, L., Linford, S., Lingford-Hughes, A., Lipman, M., Liyanage, K., Lloyd, A., Logan, S., Lomas, D., Lone, N.I., Loosley, R., Lord, J.M., Lota, H., Lovegrove, W., Lucey, A., Lukaschuk, E., Lye, A., Lynch, C., MacDonald, S., MacGowan, G., Macharia, I., Mackie, J., Macliver, L., Madathil, S., Madzamba, G., Magee, N., Magtoto, M.M., Mairs, N., Majeed, N., Major, E., Malein, F., Malim, M., Mallison, G., D-C Man, W., Mandal, S., Mangion, K., Manisty, C., Manley, R., March, K., Marciniak, S., Marino, P., Mariveles, M., Marks, M., Marouzet, E., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martineau, A., Martinez, L.M., Maskell, N., Matila, D., Matimba-Mupaya, W., Matthews, L., Mbuyisa, A., McAdoo, S., McAllister-Williams, H., McArdle, A., McArdle, P., McAulay, D., McCann, G.P., McCormick, J., McCormick, W., McCourt, P., McGarvey, L., McGee, C., Mcgee, K., McGinness, J., McGlynn, K., McGovern, A., McGuinness, H., McInnes, I.B., McIntosh, J., McIvor, E., McIvor, K., McLeavey, L., McMahon, A., McMahon, M.J., McMorrow, L., Mcnally, T., McNarry, M., McNeill, J., McQueen, A., McShane, H., Mears, C., Megson, C., Megson, S., Mehta, P., Meiring, J., Melling, L., Mencias, M., Menzies, D., Merida Morillas, M., Michael, A., Miller, C., Milligan, L., Mills, C., Mills, G., Mills, N.L., Milner, L., Misra, S., Mitchell, J., Mohamed, A., Mohamed, N., Mohammed, S., Molyneaux, P.L., Monteiro, W., Moriera, S., Morley, A., Morrison, L., Morriss, R., Morrow, A., Moss, A.J., Moss, P., Motohashi, K., Msimanga, N., Mukaetova-Ladinska, E., Munawar, U., Murira, J., Nanda, U., Nassa, H., Nasseri, M., Neal, A., Needham, R., Neill, P., Neubauer, S., Newby, D.E., Newell, H., Newman, T., Newman, J., Newton-Cox, A., Nicholson, T., Nicoll, D., Nikolaidis, A., Nolan, C.M., Noonan, M.J., Norman, C., Novotny, P., Nunag, J., Nwafor, L., Nwanguma, U., Nyaboko, J., O'Brien, C., O'Donnell, K., O'Regan, D., O’Brien, L., Odell, N., Ogg, G., Olaosebikan, O., Oliver, C., Omar, Z., Openshaw, P.J.M., Orriss-Dib, L., Osborne, L., Osbourne, R., Ostermann, M., Overton, C., Owen, J., Oxton, J., Pack, J., Pacpaco, E., Paddick, S., Painter, S., Pakzad, A., Palmer, S., Papineni, P., Paques, K., Paradowski, K., Pareek, M., Parekh, D., Parfrey, H., Pariante, C., Parker, S., Parkes, M., Parmar, J., Patale, S., Patel, B., Patel, M., Patel, S., Pattenadk, D., Pavlides, M., Payne, S., Pearce, L., Pearl, J.E., Peckham, D., Pendlebury, J., Peng, Y., Pennington, C., Peralta, I., Perkins, E., Peterkin, Z., Peto, T., Petousi, N., Petrie, J., Pfeffer, P., Phipps, J., Pimm, J., Piper Hanley, K., Pius, R., Plant, H., Plein, S., Plekhanova, T., Plowright, M., Poinasamy, K., Polgar, O., Poll, L., Porter, J.C., Porter, J., Portukhay, S., Powell, N., Prabhu, A., Pratt, J., Price, A., Price, C., Price, D., Price, L., Prickett, A., Propescu, J., Prosper, S., Pugmire, S., Quaid, S., Quigley, J., Quint, J., Qureshi, H., Qureshi, I.N., Radhakrishnan, K., Rahman, N.M., Ralser, M., Raman, B., Ramos, A., Ramos, H., Rangeley, J., Rangelov, B., Ratcliffe, L., Ravencroft, P., Reddington, A., Reddy, R., Reddy, A., Redfearn, H., Redwood, D., Reed, A., Rees, M., Rees, T., Regan, K., Reynolds, W., Ribeiro, C., Richards, A., Richardson, E., Richardson, M., Rivera-Ortega, P., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Roche, L., Roddis, C., Rodger, J., Ross, A., Ross, G., Rossdale, J., Rostron, A., Rowe, A., Rowland, A., Rowland, J., Rowland, M.J., Rowland-Jones, S.L., Roy, K., Roy, M., Rudan, I., Russell, R., Russell, E., Saalmink, G., Sabit, R., Sage, E.K., Samakomva, T., Samani, N., Sampson, C., Samuel, K., Samuel, R., Sanderson, A., Sapey, E., Saralaya, D., Sargant, J., Sarginson, C., Sass, T., Sattar, N., Saunders, K., Saunders, R.M., Saunders, P., Saunders, L.C., Savill, H., Saxon, W., Sayer, A., Schronce, J., Schwaeble, W., Scott, J.T., Scott, K., Selby, N., Semple, M.G., Sereno, M., Sewell, T.A., Shah, A., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Sharpe, M., Shashaa, S., Shaw, A., Shaw, K., Shaw, V., Sheikh, A., Shelton, S., Shenton, L., Shevket, K., Shikotra, A., Short, J., Siddique, S., Siddiqui, S., Sidebottom, J., Sigfrid, L., Simons, G., Simpson, J., Simpson, N., Singapuri, A., Singh, C., Singh, S., Singh, S.J., Sissons, D., Skeemer, J., Slack, K., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Soares, M., Solano, T.S., Solly, R., Solstice, A.R., Soulsby, T., Southern, D., Sowter, D., Spears, M., Spencer, L.G., Speranza, F., Stadon, L., Stanel, S., Steele, N., Steiner, M., Stensel, D., Stephens, G., Stephenson, L., Stern, M., Stewart, I., Stimpson, R., Stockdale, S., Stockley, J., Stoker, W., Stone, R., Storrar, W., Storrie, A., Storton, K., Stringer, E., Strong-Sheldrake, S., Stroud, N., Subbe, C., Sudlow, C.L., Suleiman, Z., Summers, C., Summersgill, C., Sutherland, D., Sykes, D.L., Sykes, R., Talbot, N., Tan, A.L., Tarusan, L., Tavoukjian, V., Taylor, A., Taylor, C., Taylor, J., Te, A., Tedd, H., Tee, C.J., Teixeira, J., Tench, H., Terry, S., Thackray-Nocera, S., Thaivalappil, F., Thamu, B., Thickett, D., Thomas, C., Thomas, D.C., Thomas, S., Thomas, A.K., Thomas-Woods, T., Thompson, T., Thompson, A.A.R., Thornton, T., Thorpe, M., Thwaites, R.S., Tilley, J., Tinker, N., Tiongson, G.F., Tobin, M., Tomlinson, J., Tong, C., Toshner, M., Touyz, R., Tripp, K.A., Tunnicliffe, E., Turnbull, A., Turner, E., Turner, S., Turner, V., Turner, K., Turney, S., Turtle, L., Turton, H., Ugoji, J., Ugwuoke, R., Upthegrove, R., Valabhji, J., Ventura, M., Vere, J., Vickers, C., Vinson, B., Wade, E., Wade, P., Wain, L.V., Wainwright, T., Wajero, L.O., Walder, S., Walker, S., Wall, E., Wallis, T., Walmsley, S., Walsh, J.A., Walsh, S., Warburton, L., Ward, T.J.C., Warwick, K., Wassall, H., Waterson, S., Watson, E., Watson, L., Watson, J., Weir McCall, J., Welch, C., Welch, H., Welsh, B., Wessely, S., West, S., Weston, H., Wheeler, H., White, S., Whitehead, V., Whitney, J., Whittaker, S., Whittam, B., Whitworth, V., Wight, A., Wild, J., Wilkins, M., Wilkinson, D., Williams, B., Williams, N., Williams, J., Williams-Howard, S.A., Willicombe, M., Willis, G., Willoughby, J., Wilson, A., Wilson, D., Wilson, I., Window, N., Witham, M., Wolf-Roberts, R., Wood, C., Woodhead, F., Woods, J., Wootton, D.G., Wormleighton, J., Worsley, J., Wraith, D., Wrey Brown, C., Wright, C., Wright, L., Wright, S., Wyles, J., Wynter, I., Xu, M., Yasmin, N., Yasmin, S., Yates, T., Yip, K.P., Young, B., Young, S., Young, A., Yousuf, A.J., Zawia, A., Zeidan, L., Zhao, B., Zheng, B., Zongo, O., McAuley, Hamish J.C., Evans, Rachael A., Bolton, Charlotte E., Brightling, Christopher E., Chalmers, James D., Docherty, Annemarie B., Elneima, Omer, Greenhaff, Paul L., Gupta, Ayushman, Harris, Victoria C., Harrison, Ewen M., Ho, Ling-Pei, Horsley, Alex, Houchen-Wolloff, Linzy, Jolley, Caroline J., Leavy, Olivia C., Lone, Nazir I., Man, William D-C, Marks, Michael, Parekh, Dhruv, Poinasamy, Krisnah, Quint, Jennifer K., Raman, Betty, Richardson, Matthew, Saunders, Ruth M., Sereno, Marco, Shikotra, Aarti, Singapuri, Amisha, Singh, Sally J., Steiner, Michael, Tan, Ai Lyn, Wain, Louise V., Welch, Carly, Whitney, Julie, Witham, Miles D., Lord, Janet, and Greening, Neil J.

Published
2023
Full Text
View/download PDF

7. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Author

Baillie, J. Kenneth, Openshaw, Peter J.M., Semple, Malcolm G., Alex, Beatrice, Andrikopoulos, Petros, Bach, Benjamin, Barclay, Wendy S., Bogaert, Debby, Chand, Meera, Chechi, Kanta, Cooke, Graham S., da Silva Filipe, Ana, de Silva, Thushan, Docherty, Annemarie B., dos Santos Correia, Gonçalo, Dumas, Marc-Emmanuel, Dunning, Jake, Fletcher, Tom, Green, Christopher A., Greenhalf, William, Griffin, Julian, Gupta, Rishi K., Harrison, Ewen M., Ho, Antonia Y.W., Holden, Karl, Horby, Peter W., Ijaz, Samreen, Khoo, Say, Klenerman, Paul, Law, Andrew, Lewis, Matthew, Liggi, Sonia, Lim, Wei Shen, Maslen, Lynn, Mentzer, Alexander J., Merson, Laura, Meynert, Alison M, Moore, Shona C., Noursadeghi, Mahdad, Olanipekun, Michael, Osagie, Anthonia, Palmarini, Massimo, Palmieri, Carlo, Paxton, William A., Pollakis, Georgios, Price, Nicholas, Rambaut, Andrew, Robertson, David L, Russell, Clark D., Sancho-Shimizu, Vanessa, Sands, Caroline, Scott, Janet T., Sigfrid, Louise, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Summers, Charlotte, Swann, Olivia V., Takats, Zoltan, Takis, Panteleimon, Tedder, Richard S., Thompson, A.A. Roger, Thomson, Emma C., Thwaites, Ryan S., Turtle, Lance C.W., Zambon, Maria, Drake, Thomas M., Fairfield, Cameron J., Knight, Stephen R., Mclean, Kenneth A., Murphy, Derek, Norman, Lisa, Pius, Riinu, Shaw, Catherine A., Connor, Marie, Dalton, Jo, Gamble, Carrol, Girvan, Michelle, Halpin, Sophie, Harrison, Janet, Jackson, Clare, Lee, James, Marsh, Laura, Plotkin, Daniel, Roberts, Stephanie, Saviciute, Egle, Clohisey, Sara, Hendry, Ross, Knight, Susan, Lahnsteiner, Eva, Leeming, Gary, Norris, Lucy, Scott-Brown, James, Tait, Sarah, Wham, Murray, Clark, Richard, Coutts, Audrey, Donelly, Lorna, Fawkes, Angie, Gilchrist, Tammy, Hafezi, Katarzyna, MacGillivray, Louise, Maclean, Alan, McCafferty, Sarah, Morrice, Kirstie, Murphy, Lee, Wrobel, Nicola, Carson, Gail, Adeniji, Kayode, Agranoff, Daniel, Agwuh, Ken, Ail, Dhiraj, Aldera, Erin L., Alegria, Ana, Allen, Sam, Angus, Brian, Ashish, Abdul, Atkinson, Dougal, Bari, Shahedal, Barlow, Gavin, Barnass, Stella, Barrett, Nicholas, Bassford, Christopher, Basude, Sneha, Baxter, David, Beadsworth, Michael, Bernatoniene, Jolanta, Berridge, John, Berry, Colin, Best, Nicola, Bothma, Pieter, Brittain-Long, Robin, Bulteel, Naomi, Burden, Tom, Burtenshaw, Andrew, Caruth, Vikki, Chadwick, David, Chambler, Duncan, Chee, Nigel, Child, Jenny, Chukkambotla, Srikanth, Clark, Tom, Collini, Paul, Cosgrove, Catherine, Cupitt, Jason, Cutino-Moguel, Maria-Teresa, Dark, Paul, Dawson, Chris, Dervisevic, Samir, Donnison, Phil, Douthwaite, Sam, Drummond, Andrew, DuRand, Ingrid, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Eziefula, Chi, Fegan, Chrisopher, Finn, Adam, Fullerton, Duncan, Garg, Sanjeev, Garg, Atul, Gkrania-Klotsas, Effrossyni, Godden, Jo, Goldsmith, Arthur, Graham, Clive, Grammatikopoulos, Tassos, Hardy, Elaine, Hartshorn, Stuart, Harvey, Daniel, Havalda, Peter, Hawcutt, Daniel B., Hobrok, Maria, Hodgson, Luke, Hormis, Anil, Howard, Joanne, Jacobs, Michael, Jain, Susan, Jennings, Paul, Kaliappan, Agilan, Kasipandian, Vidya, Kegg, Stephen, Kelsey, Michael, Kendall, Jason, Kerrison, Caroline, Kerslake, Ian, Koch, Oliver, Koduri, Gouri, Koshy, George, Laha, Shondipon, Laird, Steven, Larkin, Susan, Leiner, Tamas, Lillie, Patrick, Limb, James, Linnett, Vanessa, Little, Jeff, Lyttle, Mark, MacMahon, Michael, MacNaughton, Emily, Mankregod, Ravish, Masson, Huw, Matovu, Elijah, McCullough, Katherine, McEwen, Ruth, Meda, Manjula, Mills, Gary, Minton, Jane, Mohandas, Kavya, Mok, Quen, Moon, James, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Mortimore, Katherine, Moses, Samuel, Mpenge, Mbiye, Mulla, Rohinton, Murphy, Michael, Nagarajan, Thapas, Nagel, Megan, Nelson, Mark, Norris, Lillian, O'Shea, Matthew K., Ostermann, Marlies, Otahal, Igor, Pais, Mark, Panchatsharam, Selva, Papakonstantinou, Danai, Papineni, Padmasayee, Paraiso, Hassan, Patel, Brij, Pattison, Natalie, Pepperell, Justin, Peters, Mark, Phull, Mandeep, Pintus, Stefania, Planche, Tim, Post, Frank, Price, David, Prout, Rachel, Rae, Nikolas, Reschreiter, Henrik, Reynolds, Tim, Richardson, Neil, Roberts, Mark, Roberts, Devender, Rose, Alistair, Rousseau, Guy, Ruge, Bobby, Ryan, Brendan, Saluja, Taranprit, Sarah, Sarah, Schmid, Matthias, Shah, Aarti, Shankar-Hari, Manu, Shanmuga, Prad, Sharma, Anil, Shawcross, Anna, Singh Pooni, Jagtur, Sizer, Jeremy, Smith, Richard, Snelson, Catherine, Spittle, Nick, Staines, Nikki, Stambach, Tom, Stewart, Richard, Subudhi, Pradeep, Szakmany, Tamas, Tatham, Kate, Thomas, Jo, Thompson, Chris, Thompson, Robert, Tridente, Ascanio, Tupper-Carey, Darell, Twagira, Mary, Vallotton, Nick, Vancheeswaran, Rama, Vincent, Rachel, Vincent-Smith, Lisa, Visuvanathan, Shico, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Walden, Andrew, Welters, Ingeborg, Whitehouse, Tony, Whittaker, Paul, Whittington, Ashley, Wijesinghe, Meme, Williams, Martin, Wilson, Lawrence, Winchester, Stephen, Wiselka, Martin, Wolverson, Adam, Wootton, Daniel G, Workman, Andrew, Yates, Bryan, Young, Peter, McDonald, Sarah E., Shaw, Victoria, Ahmed, Katie A., Armstrong, Jane A., Ashworth, Milton, Asiimwe, Innocent G., Bakshi, Siddharth, Barlow, Samantha L, Booth, Laura, Brennan, Benjamin, Bullock, Katie, Carlucci, Nicola, Cass, Emily, Catterall, Benjamin W.A., Clark, Jordan J., Clarke, Emily A., Cole, Sarah, Cooper, Louise, Cox, Helen, Davis, Christopher, Dincarslan, Oslem, Doce Carracedo, Alejandra, Dunn, Chris, Dyer, Philip, Elliott, Angela, Evans, Anthony, Finch, Lorna, Fisher, Lewis W.S., Flaherty, Lisa, Foster, Terry, Garcia-Dorival, Isabel, Gunning, Philip, Hartley, Catherine, Holmes, Anthony, Jensen, Rebecca L., Jones, Christopher B., Jones, Trevor R., Khandaker, Shadia, King, Katharine, Kiy, Robyn T., Koukorava, Chrysa, Lake, Annette, Lant, Suzannah, Latawiec, Diane, Lavelle-Langham, Lara, Lefteri, Daniella, Lett, Lauren, Livoti, Lucia A, Mancini, Maria, Massey, Hannah, Maziere, Nicole, McDonald, Sarah, McEvoy, Laurence, McLauchlan, John, Metelmann, Soeren, Miah, Nahida S., Middleton, Joanna, Mitchell, Joyce, Murphy, Ellen G, Penrice-Randal, Rebekah, Pilgrim, Jack, Prince, Tessa, Reynolds, Will, Ridley, P. Matthew, Sales, Debby, Shaw, Victoria E., Shears, Rebecca K., Small, Benjamin, Subramaniam, Krishanthi S., Szemiel, Agnieska, Taggart, Aislynn, Tanianis-Hughes, Jolanta, Thomas, Jordan, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Zhang, J. Eunice, Keating, Seán, Donegan, Cara, Spencer, Rebecca G., Donohue, Chloe, Griffiths, Fiona, Hardwick, Hayley, Oosthuyzen, Wilna, Abel, K., Adamali, H., Adeloye, D., Adeyemi, O., Adrego, R., Aguilar Jimenez, L.A., Ahmad, S., Ahmad Haider, N., Ahmed, R., Ahwireng, N., Ainsworth, M., Al-Sheklly, B., Alamoudi, A., Ali, M., Aljaroof, M., All, A.M., Allan, L., Allen, R.J., Allerton, L., Allsop, L., Almeida, P., Altmann, D., Alvarez Corral, M., Amoils, S., Anderson, D., Antoniades, C., Arbane, G., Arias, A., Armour, C., Armstrong, L., Armstrong, N., Arnold, D., Arnold, H., Ashish, A., Ashworth, A., Ashworth, M., Aslani, S., Assefa-Kebede, H., Atkin, C., Atkin, P., Aul, R., Aung, H., Austin, L., Avram, C., Ayoub, A., Babores, M., Baggott, R., Bagshaw, J., Baguley, D., Bailey, L., Baillie, J.K., Bain, S., Bakali, M., Bakau, M., Baldry, E., Baldwin, D., Baldwin, M., Ballard, C., Banerjee, A., Bang, B., Barker, R.E., Barman, L., Barratt, S., Barrett, F., Basire, D., Basu, N., Bates, M., Bates, A., Batterham, R., Baxendale, H., Bayes, H., Beadsworth, M., Beckett, P., Beggs, M., Begum, M., Beirne, P., Bell, D., Bell, R., Bennett, K., Beranova, E., Bermperi, A., Berridge, A., Berry, C., Betts, S., Bevan, E., Bhui, K., Bingham, M., Birchall, K., Bishop, L., Bisnauthsing, K., Blaikely, J., Bloss, A., Bolger, A., Bolton, C.E., Bonnington, J., Botkai, A., Bourne, C., Bourne, M., Bramham, K., Brear, L., Breen, G., Breeze, J., Briggs, A., Bright, E., Brightling, C.E., Brill, S., Brindle, K., Broad, L., Broadley, A., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J.S., Brown, M., Brown, V., Brugha, T., Brunskill, N., Buch, M., Buckley, P., Bularga, A., Bullmore, E., Burden, L., Burdett, T., Burn, D., Burns, G., Burns, A., Busby, J., Butcher, R., Butt, A., Byrne, S., Cairns, P., Calder, P.C., Calvelo, E., Carborn, H., Card, B., Carr, C., Carr, L., Carson, G., Carter, P., Casey, A., Cassar, M., Cavanagh, J., Chablani, M., Chalder, T., Chalmers, J.D., Chambers, R.C., Chan, F., Channon, K.M., Chapman, K., Charalambou, A., Chaudhuri, N., Checkley, A., Chen, J., Cheng, Y., Chetham, L., Childs, C., Chilvers, E.R., Chinoy, H., Chiribiri, A., Chong-James, K., Choudhury, G., Choudhury, N., Chowienczyk, P., Christie, C., Chrystal, M., Clark, D., Clark, C., Clarke, J., Clohisey, S., Coakley, G., Coburn, Z., Coetzee, S., Cole, J., Coleman, C., Conneh, F., Connell, D., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Copeland, D., Cosier, T., Coulding, M., Coupland, C., Cox, E., Craig, T., Crisp, P., Cristiano, D., Crooks, M.G., Cross, A., Cruz, I., Cullinan, P., Cuthbertson, D., Daines, L., Dalton, M., Daly, P., Daniels, A., Dark, P., Dasgin, J., David, A., David, C., Davies, E., Davies, F., Davies, G., Davies, G.A., Davies, K., Davies, M.J., Dawson, J., Daynes, E., De Soyza, A., Deakin, B., Deans, A., Deas, C., Deery, J., Defres, S., Dell, A., Dempsey, K., Denneny, E., Dennis, J., Dewar, A., Dharmagunawardena, R., Diar-Bakerly, N., Dickens, C., Dipper, A., Diver, S., Diwanji, S.N., Dixon, M., Djukanovic, R., Dobson, H., Dobson, S.L., Docherty, A.B., Donaldson, A., Dong, T., Dormand, N., Dougherty, A., Dowling, R., Drain, S., Draxlbauer, K., Drury, K., Dulawan, P., Dunleavy, A., Dunn, S., Dupont, C., Earley, J., Easom, N., Echevarria, C., Edwards, S., Edwardson, C., El-Taweel, H., Elliott, A., Elliott, K., Ellis, Y., Elmer, A., Elneima, O., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R.A., Evans, R.I., Evans, T., Evenden, C., Evison, L., Fabbri, L., Fairbairn, S., Fairman, A., Fallon, K., Faluyi, D., Favager, C., Fayzan, T., Featherstone, J., Felton, T., Finch, J., Finney, S., Finnigan, J., Finnigan, L., Fisher, H., Fletcher, S., Flockton, R., Flynn, M., Foot, H., Foote, D., Ford, A., Forton, D., Fraile, E., Francis, C., Francis, R., Francis, S., Frankel, A., Fraser, E., Free, R., French, N., Fu, X., Fuld, J., Furniss, J., Garner, L., Gautam, N., Geddes, J.R., George, J., George, P., Gibbons, M., Gill, M., Gilmour, L., Gleeson, F., Glossop, J., Glover, S., Goodman, N., Goodwin, C., Gooptu, B., Gordon, H., Gorsuch, T., Greatorex, M., Greenhaff, P.L., Greenhalf, W., Greenhalgh, A., Greening, N.J., Greenwood, J., Gregory, H., Gregory, R., Grieve, D., Griffin, D., Griffiths, L., Guerdette, A-M., Guillen Guio, B., Gummadi, M., Gupta, A., Gurram, S., Guthrie, E., Guy, Z., H Henson, H., Hadley, K., Haggar, A., Hainey, K., Hairsine, B., Haldar, P., Hall, I., Hall, L., Halling-Brown, M., Hamil, R., Hancock, A., Hancock, K., Hanley, N.A., Haq, S., Hardwick, H.E., Hardy, E., Hardy, T., Hargadon, B., Harrington, K., Harris, E., Harris, V.C., Harrison, E.M., Harrison, P., Hart, N., Harvey, A., Harvey, M., Harvie, M., Haslam, L., Havinden-Williams, M., Hawkes, J., Hawkings, N., Haworth, J., Hayday, A., Haynes, M., Hazeldine, J., Hazelton, T., Heaney, L.G., Heeley, C., Heeney, J.L., Heightman, M., Heller, S., Henderson, M., Hesselden, L., Hewitt, M., Highett, V., Hillman, T., Hiwot, T., Ho, L.P., Hoare, A., Hoare, M., Hockridge, J., Hogarth, P., Holbourn, A., Holden, S., Holdsworth, L., Holgate, D., Holland, M., Holloway, L., Holmes, K., Holmes, M., Holroyd-Hind, B., Holt, L., Hormis, A., Horsley, A., Hosseini, A., Hotopf, M., Houchen-Wolloff, L., Howard, K., Howard, L.S., Howell, A., Hufton, E., Hughes, A.D., Hughes, J., Hughes, R., Humphries, A., Huneke, N., Hurditch, E., Hurst, J., Husain, M., Hussell, T., Hutchinson, J., Ibrahim, W., Ilyas, F., Ingham, J., Ingram, L., Ionita, D., Isaacs, K., Ismail, K., Jackson, T., Jacob, J., James, W.Y., Jang, W., Jarman, C., Jarrold, I., Jarvis, H., Jastrub, R., Jayaraman, B., Jenkins, R.G., Jezzard, P., Jiwa, K., Johnson, C., Johnson, S., Johnston, D., Jolley, C.J., Jones, D., Jones, G., Jones, H., Jones, I., Jones, L., Jones, M.G., Jones, S., Jose, S., Kabir, T., Kaltsakas, G., Kamwa, V., Kanellakis, N., Kaprowska, s., Kausar, Z., Keenan, N., Kelly, S., Kemp, G., Kerr, S., Kerslake, H., Key, A.L., Khan, F., Khunti, K., Kilroy, S., King, B., King, C., Kingham, L., Kirk, J., Kitterick, P., Klenerman, P., Knibbs, L., Knight, S., Knighton, A., Kon, O., Kon, S., Kon, S.S., Koprowska, S., Korszun, A., Koychev, I., Kurasz, C., Kurupati, P., Laing, C., Lamlum, H., Landers, G., Langenberg, C., Lasserson, D., Lavelle-Langham, L., Lawrie, A., Lawson, C., Layton, A., Lea, A., Leavy, O.C., Lee, D., Lee, J-H., Lee, E., Leitch, K., Lenagh, R., Lewis, D., Lewis, J., Lewis, K.E., Lewis, V., Lewis-Burke, N., Li, X., Light, T., Lightstone, L., Lilaonitkul, W., Lim, L., Linford, S., Lingford-Hughes, A., Lipman, M., Liyanage, K., Lloyd, A., Logan, S., Lomas, D., Lone, N.I., Loosley, R., Lord, J.M., Lota, H., Lovegrove, W., Lucey, A., Lukaschuk, E., Lye, A., Lynch, C., MacDonald, S., MacGowan, G., Macharia, I., Mackie, J., Macliver, L., Madathil, S., Madzamba, G., Magee, N., Magtoto, M.M., Mairs, N., Majeed, N., Major, E., Malein, F., Malim, M., Mallison, G., Man, W.D.-C., Mandal, S., Mangion, K., Manisty, C., Manley, R., March, K., Marciniak, S., Marino, P., Mariveles, M., Marks, M., Marouzet, E., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martineau, A., Martinez, L.M., Maskell, N., Matila, D., Matimba-Mupaya, W., Matthews, L., Mbuyisa, A., McAdoo, S., McAllister-Williams, H., McArdle, A., McArdle, P., McAulay, D., McCann, G.P., drury, H.J.C., McCormick, J., McCormick, W., McCourt, P., McGarvey, L., McGee, C., Mcgee, K., McGinness, J., McGlynn, K., McGovern, A., McGuinness, H., McInnes, I.B., McIntosh, J., McIvor, E., McIvor, K., McLeavey, L., McMahon, A., McMahon, M.J., McMorrow, L., Mcnally, T., McNarry, M., McNeill, J., McQueen, A., McShane, H., Mears, C., Megson, C., Megson, S., Mehta, P., Meiring, J., Melling, L., Mencias, M., Menzies, D., Merida Morillas, M., Michael, A., Miller, C., Milligan, L., Mills, C., Mills, N.L., Milner, L., Misra, S., Mitchell, J., Mohamed, A., Mohamed, N., Mohammed, S., Molyneaux, P.L., Monteiro, W., Moriera, S., Morley, A., Morrison, L., Morriss, R., Morrow, A., Moss, A.J., Moss, P., Motohashi, K., Msimanga, N., Mukaetova-Ladinska, E., Munawar, U., Murira, J., Nanda, U., Nassa, H., Nasseri, M., Neal, A., Needham, R., Neill, P., Neubauer, S., Newby, D.E., Newell, H., Newman, T., Newton-Cox, A., Nicholson, T., Nicoll, D., Nikolaidis, A., Nolan, C.M., Noonan, M.J., Norman, C., Novotny, P., Nunag, J., Nwafor, L., Nwanguma, U., Nyaboko, J., O'Brien, C., O'Donnell, K., O'Regan, D., O'Brien, L., Odell, N., Ogg, G., Olaosebikan, O., Oliver, C., Omar, Z., Openshaw, P.J.M., Orriss-Dib, L., Osborne, L., Osbourne, R., Ostermann, M., Overton, C., Owen, J., Oxton, J., Pack, J., Pacpaco, E., Paddick, S., Painter, S., Pakzad, A., Palmer, S., Papineni, P., Paques, K., Paradowski, K., Pareek, M., Parekh, D., Parfrey, H., Pariante, C., Parker, S., Parkes, M., Parmar, J., Patale, S., Patel, B., Patel, M., Patel, S., Pattenadk, D., Pavlides, M., Payne, S., Pearce, L., Pearl, J.E., Peckham, D., Pendlebury, J., Peng, Y., Pennington, C., Peralta, I., Perkins, E., Peterkin, Z., Peto, T., Petousi, N., Petrie, J., Pfeffer, P., Phipps, J., Pimm, J., Piper Hanley, K., Pius, R., Plant, H., Plein, S., Plekhanova, T., Plowright, M., Poinasamy, K., Polgar, O., Poll, L., Porter, J.C., Porter, J., Portukhay, S., Powell, N., Prabhu, A., Pratt, J., Price, A., Price, C., Price, D., Price, L., Prickett, A., Propescu, J., Prosper, S., Pugmire, S., Quaid, S., Quigley, J., Quint, J., Qureshi, H., Qureshi, I.N., Radhakrishnan, K., Rahman, N.M., Ralser, M., Raman, B., Ramos, A., Ramos, H., Rangeley, J., Rangelov, B., Ratcliffe, L., Ravencroft, P., Reddington, A., Reddy, R., Redfearn, H., Redwood, D., Reed, A., Rees, M., Rees, T., Regan, K., Reynolds, W., Ribeiro, C., Richards, A., Richardson, E., Richardson, M., Rivera-Ortega, P., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Roche, L., Roddis, C., Rodger, J., Ross, A., Ross, G., Rossdale, J., Rostron, A., Rowe, A., Rowland, A., Rowland, J., Rowland, M.J., Rowland-Jones, S.L., Roy, K., Roy, M., Rudan, I., Russell, R., Russell, E., Saalmink, G., Sabit, R., Sage, E.K., Samakomva, T., Samani, N., Sampson, C., Samuel, K., Samuel, R., Sanderson, A., Sapey, E., Saralaya, D., Sargant, J., Sarginson, C., Sass, T., Sattar, N., Saunders, K., Saunders, R.M., Saunders, P., Saunders, L.C., Savill, H., Saxon, W., Sayer, A., Schronce, J., Schwaeble, W., Scott, J.T., Scott, K., Selby, N., Semple, M.G., Sereno, M., Sewell, T.A., Shah, A., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Sharpe, M., Shashaa, S., Shaw, A., Shaw, K., Shaw, V., Sheikh, A., Shelton, S., Shenton, L., Shevket, K., Shikotra, A., Short, J., Siddique, S., Siddiqui, S., Sidebottom, J., Sigfrid, L., Simons, G., Simpson, J., Simpson, N., Singapuri, A., Singh, C., Singh, S., Singh, S.J., Sissons, D., Skeemer, J., Slack, K., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Soares, M., Solano, T.S., Solly, R., Solstice, A.R., Soulsby, T., Southern, D., Sowter, D., Spears, M., Spencer, L.G., Speranza, F., Stadon, L., Stanel, S., Steele, N., Steiner, M., Stensel, D., Stephens, G., Stephenson, L., Stern, M., Stewart, I., Stimpson, R., Stockdale, S., Stockley, J., Stoker, W., Stone, R., Storrar, W., Storrie, A., Storton, K., Stringer, E., Strong-Sheldrake, S., Stroud, N., Subbe, C., Sudlow, C.L., Suleiman, Z., Summers, C., Summersgill, C., Sutherland, D., Sykes, D.L., Sykes, R., Talbot, N., Tan, A.L., Tarusan, L., Tavoukjian, V., Taylor, A., Taylor, C., Taylor, J., Te, A., Tedd, H., Tee, C.J., Teixeira, J., Tench, H., Terry, S., Thackray-Nocera, S., Thaivalappil, F., Thamu, B., Thickett, D., Thomas, C., Thomas, D.C., Thomas, S., Thomas, A.K., Thomas-Woods, T., Thompson, T., Thompson, A.A.R., Thornton, T., Thorpe, M., Thwaites, R.S., Tilley, J., Tinker, N., Tiongson, G.F., Tobin, M., Tomlinson, J., Tong, C., Toshner, M., Touyz, R., Tripp, K.A., Tunnicliffe, E., Turnbull, A., Turner, E., Turner, S., Turner, V., Turner, K., Turney, S., Turtle, L., Turton, H., Ugoji, J., Ugwuoke, R., Upthegrove, R., Valabhji, J., Ventura, M., Vere, J., Vickers, C., Vinson, B., Wade, E., Wade, P., Wain, L.V., Wainwright, T., Wajero, L.O., Walder, S., Walker, S., Wall, E., Wallis, T., Walmsley, S., Walsh, J.A., Walsh, S., Warburton, L., Ward, T.J.C., Warwick, K., Wassall, H., Waterson, S., Watson, E., Watson, L., Watson, J., Weir McCall, J., Welch, C., Welch, H., Welsh, B., Wessely, S., West, S., Weston, H., Wheeler, H., White, S., Whitehead, V., Whitney, J., Whittaker, S., Whittam, B., Whitworth, V., Wight, A., Wild, J., Wilkins, M., Wilkinson, D., Williams, B., Williams, N., Williams, J., Williams-Howard, S.A., Willicombe, M., Willis, G., Willoughby, J., Wilson, A., Wilson, D., Wilson, I., Window, N., Witham, M., Wolf-Roberts, R., Wood, C., Woodhead, F., Woods, J., Wootton, D.G., Wormleighton, J., Worsley, J., Wraith, D., Wrey Brown, C., Wright, C., Wright, L., Wright, S., Wyles, J., Wynter, I., Xu, M., Yasmin, N., Yasmin, S., Yates, T., Yip, K.P., Young, B., Young, S., Young, A., Yousuf, A.J., Zawia, A., Zeidan, L., Zhao, B., Zheng, B., Zongo, O., Liew, Felicity, Talwar, Shubha, Cross, Andy, Willett, Brian J., Scott, Sam, Logan, Nicola, Siggins, Matthew K., Swieboda, Dawid, Sidhu, Jasmin K., Efstathiou, Claudia, Davis, Chris, Mohamed, Noura, Nunag, Jose, King, Clara, Rowland-Jones, Sarah L., Chalmers, James D., Ho, Ling-Pei, Horsley, Alexander, Raman, Betty, Poinasamy, Krisnah, Marks, Michael, Kon, Onn Min, Howard, Luke, Wootton, Daniel G., Dunachie, Susanna, Quint, Jennifer K., Evans, Rachael A., Wain, Louise V., Fontanella, Sara, de Silva, Thushan I., Ho, Antonia, Harrison, Ewen, Brightling, Christopher, and Turtle, Lance

Published
2023
Full Text
View/download PDF

8. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Author

Evans, R A, Leavy, O C, Richardson, M, Elneima, O, McAuley, H J C, Shikotra, A, Singapuri, A, Sereno, M, Saunders, R M, Harris, V C, Houchen-Wolloff, L, Aul, R, Beirne, P, Bolton, C E, Brown, J S, Choudhury, G, Diar-Bakerly, N, Easom, N, Echevarria, C, Fuld, J, Hart, N, Hurst, J, Jones, M G, Parekh, D, Pfeffer, P, Rahman, N M, Rowland-Jones, S L, Shah, A M, Wootton, D G, Chalder, T, Davies, M J, De Soyza, A, Geddes, J R, Greenhalf, W, Greening, N J, Heaney, L G, Heller, S, Howard, L S, Jacob, J, Jenkins, R G, Lord, J M, Man, W D-C, McCann, G P, Neubauer, S, Openshaw, P J M, Porter, J C, Rowland, M J, Scott, J T, Semple, M G, Singh, S J, Thomas, D C, Toshner, M, Lewis, K E, Thwaites, R S, Briggs, A, Docherty, A B, Kerr, S, Lone, N I, Quint, J, Sheikh, A, Thorpe, M, Zheng, B, Chalmers, J D, Ho, L P, Horsley, A, Marks, M, Poinasamy, K, Raman, B, Harrison, E M, Wain, L V, Brightling, C E, Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adrego, R, Aguilar Jimenez, L A, Ahmad, S, Ahmad Haider, N, Ahmed, R, Ahwireng, N, Ainsworth, M, Al-Sheklly, B, Alamoudi, A, Ali, M, Aljaroof, M, All, AM, Allan, L, Allen, R J, Allerton, L, Allsop, L, Almeida, P, Altmann, D, Alvarez Corral, M, Amoils, S, Anderson, D, Antoniades, C, Arbane, G, Arias, A, Armour, C, Armstrong, L, Armstrong, N, Arnold, D, Arnold, H, Ashish, A, Ashworth, A, Ashworth, M, Aslani, S, Assefa-Kebede, H, Atkin, C, Atkin, P, Aung, H, Austin, L, Avram, C, Ayoub, A, Babores, M, Baggott, R, Bagshaw, J, Baguley, D, Bailey, L, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Ballard, C, Banerjee, A, Bang, B, Barker, R E, Barman, L, Barratt, S, Barrett, F, Basire, D, Basu, N, Bates, M, Bates, A, Batterham, R, Baxendale, H, Bayes, H, Beadsworth, M, Beckett, P, Beggs, M, Begum, M, Bell, D, Bell, R, Bennett, K, Beranova, E, Bermperi, A, Berridge, A, Berry, C, Betts, S, Bevan, E, Bhui, K, Bingham, M, Birchall, K, Bishop, L, Bisnauthsing, K, Blaikely, J, Bloss, A, Bolger, A, Bonnington, J, Botkai, A, Bourne, C, Bourne, M, Bramham, K, Brear, L, Breen, G, Breeze, J, Bright, E, Brill, S, Brindle, K, Broad, L, Broadley, A, Brookes, C, Broome, M, Brown, A, Brown, J, Brown, M, Brown, V, Brugha, T, Brunskill, N, Buch, M, Buckley, P, Bularga, A, Bullmore, E, Burden, L, Burdett, T, Burn, D, Burns, G, Burns, A, Busby, J, Butcher, R, Butt, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Carborn, H, Card, B, Carr, C, Carr, L, Carson, G, Carter, P, Casey, A, Cassar, M, Cavanagh, J, Chablani, M, Chambers, R C, Chan, F, Channon, K M, Chapman, K, Charalambou, A, Chaudhuri, N, Checkley, A, Chen, J, Cheng, Y, Chetham, L, Childs, C, Chilvers, E R, Chinoy, H, Chiribiri, A, Chong-James, K, Choudhury, N, Chowienczyk, P, Christie, C, Chrystal, M, Clark, D, Clark, C, Clarke, J, Clohisey, S, Coakley, G, Coburn, Z, Coetzee, S, Cole, J, Coleman, C, Conneh, F, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Cooper, J, Cooper, S, Copeland, D, Cosier, T, Coulding, M, Coupland, C, Cox, E, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Cuthbertson, D, Daines, L, Dalton, M, Daly, P, Daniels, A, Dark, P, Dasgin, J, David, A, David, C, Davies, E, Davies, F, Davies, G, Davies, G A, Davies, K, Dawson, J, Daynes, E, Deakin, B, Deans, A, Deas, C, Deery, J, Defres, S, Dell, A, Dempsey, K, Denneny, E, Dennis, J, Dewar, A, Dharmagunawardena, R, Dickens, C, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, S L, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Draxlbauer, K, Drury, K, Dulawan, P, Dunleavy, A, Dunn, S, Earley, J, Edwards, S, Edwardson, C, El-Taweel, H, Elliott, A, Elliott, K, Ellis, Y, Elmer, A, Evans, D, Evans, H, Evans, J, Evans, R, Evans, R I, Evans, T, Evenden, C, Evison, L, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Fayzan, T, Featherstone, J, Felton, T, Finch, J, Finney, S, Finnigan, J, Finnigan, L, Fisher, H, Fletcher, S, Flockton, R, Flynn, M, Foot, H, Foote, D, Ford, A, Forton, D, Fraile, E, Francis, C, Francis, R, Francis, S, Frankel, A, Fraser, E, Free, R, French, N, Fu, X, Furniss, J, Garner, L, Gautam, N, George, J, George, P, Gibbons, M, Gill, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Goodwin, C, Gooptu, B, Gordon, H, Gorsuch, T, Greatorex, M, Greenhaff, P L, Greenhalgh, A, Greenwood, J, Gregory, H, Gregory, R, Grieve, D, Griffin, D, Griffiths, L, Guerdette, A-M, Guillen Guio, B, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Guy, Z, H Henson, H, Hadley, K, Haggar, A, Hainey, K, Hairsine, B, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hancock, A, Hancock, K, Hanley, N A, Haq, S, Hardwick, H E, Hardy, E, Hardy, T, Hargadon, B, Harrington, K, Harris, E, Harrison, P, Harvey, A, Harvey, M, Harvie, M, Haslam, L, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Haynes, M, Hazeldine, J, Hazelton, T, Heeley, C, Heeney, J L, Heightman, M, Henderson, M, Hesselden, L, Hewitt, M, Highett, V, Hillman, T, Hiwot, T, Hoare, A, Hoare, M, Hockridge, J, Hogarth, P, Holbourn, A, Holden, S, Holdsworth, L, Holgate, D, Holland, M, Holloway, L, Holmes, K, Holmes, M, Holroyd-Hind, B, Holt, L, Hormis, A, Hosseini, A, Hotopf, M, Howard, K, Howell, A, Hufton, E, Hughes, A D, Hughes, J, Hughes, R, Humphries, A, Huneke, N, Hurditch, E, Husain, M, Hussell, T, Hutchinson, J, Ibrahim, W, Ilyas, F, Ingham, J, Ingram, L, Ionita, D, Isaacs, K, Ismail, K, Jackson, T, James, W Y, Jarman, C, Jarrold, I, Jarvis, H, Jastrub, R, Jayaraman, B, Jezzard, P, Jiwa, K, Johnson, C, Johnson, S, Johnston, D, Jolley, C J, Jones, D, Jones, G, Jones, H, Jones, I, Jones, L, Jones, S, Jose, S, Kabir, T, Kaltsakas, G, Kamwa, V, Kanellakis, N, Kaprowska, s, Kausar, Z, Keenan, N, Kelly, S, Kemp, G, Kerslake, H, Key, A L, Khan, F, Khunti, K, Kilroy, S, King, B, King, C, Kingham, L, Kirk, J, Kitterick, P, Klenerman, P, Knibbs, L, Knight, S, Knighton, A, Kon, O, Kon, S, Kon, S S, Koprowska, S, Korszun, A, Koychev, I, Kurasz, C, Kurupati, P, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lavelle-Langham, L, Lawrie, A, Lawson, C, Layton, A, Lea, A, Lee, D, Lee, J-H, Lee, E, Leitch, K, Lenagh, R, Lewis, D, Lewis, J, Lewis, V, Lewis-Burke, N, Li, X, Light, T, Lightstone, L, Lilaonitkul, W, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Loosley, R, Lota, H, Lovegrove, W, Lucey, A, Lukaschuk, E, Lye, A, Lynch, C, MacDonald, S, MacGowan, G, Macharia, I, Mackie, J, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Magtoto, M M, Mairs, N, Majeed, N, Major, E, Malein, F, Malim, M, Mallison, G, Mandal, S, Mangion, K, Manisty, C, Manley, R, March, K, Marciniak, S, Marino, P, Mariveles, M, Marouzet, E, Marsh, S, Marshall, B, Marshall, M, Martin, J, Martineau, A, Martinez, L M, Maskell, N, Matila, D, Matimba-Mupaya, W, Matthews, L, Mbuyisa, A, McAdoo, S, Weir McCall, J, McAllister-Williams, H, McArdle, A, McArdle, P, McAulay, D, McCormick, J, McCormick, W, McCourt, P, McGarvey, L, McGee, C, Mcgee, K, McGinness, J, McGlynn, K, McGovern, A, McGuinness, H, McInnes, I B, McIntosh, J, McIvor, E, McIvor, K, McLeavey, L, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McNeill, J, McQueen, A, McShane, H, Mears, C, Megson, C, Megson, S, Mehta, P, Meiring, J, Melling, L, Mencias, M, Menzies, D, Merida Morillas, M, Michael, A, Milligan, L, Miller, C, Mills, C, Mills, N L, Milner, L, Misra, S, Mitchell, J, Mohamed, A, Mohamed, N, Mohammed, S, Molyneaux, P L, Monteiro, W, Moriera, S, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A J, Moss, P, Motohashi, K, Msimanga, N, Mukaetova-Ladinska, E, Munawar, U, Murira, J, Nanda, U, Nassa, H, Nasseri, M, Neal, A, Needham, R, Neill, P, Newell, H, Newman, T, Newton-Cox, A, Nicholson, T, Nicoll, D, Nolan, C M, Noonan, M J, Norman, C, Novotny, P, Nunag, J, Nwafor, L, Nwanguma, U, Nyaboko, J, O'Donnell, K, O'Brien, C, O'Brien, L, O'Regan, D, Odell, N, Ogg, G, Olaosebikan, O, Oliver, C, Omar, Z, Orriss-Dib, L, Osborne, L, Osbourne, R, Ostermann, M, Overton, C, Owen, J, Oxton, J, Pack, J, Pacpaco, E, Paddick, S, Painter, S, Pakzad, A, Palmer, S, Papineni, P, Paques, K, Paradowski, K, Pareek, M, Parfrey, H, Pariante, C, Parker, S, Parkes, M, Parmar, J, Patale, S, Patel, B, Patel, M, Patel, S, Pattenadk, D, Pavlides, M, Payne, S, Pearce, L, Pearl, J E, Peckham, D, Pendlebury, J, Peng, Y, Pennington, C, Peralta, I, Perkins, E, Peterkin, Z, Peto, T, Petousi, N, Petrie, J, Phipps, J, Pimm, J, Piper Hanley, K, Pius, R, Plant, H, Plein, S, Plekhanova, T, Plowright, M, Polgar, O, Poll, L, Porter, J, Portukhay, S, Powell, N, Prabhu, A, Pratt, J, Price, A, Price, C, Price, D, Price, L, Prickett, A, Propescu, J, Pugmire, S, Quaid, S, Quigley, J, Qureshi, H, Qureshi, I N, Radhakrishnan, K, Ralser, M, Ramos, A, Ramos, H, Rangeley, J, Rangelov, B, Ratcliffe, L, Ravencroft, P, Reddington, A, Reddy, R, Redfearn, H, Redwood, D, Reed, A, Rees, M, Rees, T, Regan, K, Reynolds, W, Ribeiro, C, Richards, A, Richardson, E, Rivera-Ortega, P, Roberts, K, Robertson, E, Robinson, E, Robinson, L, Roche, L, Roddis, C, Rodger, J, Ross, A, Ross, G, Rossdale, J, Rostron, A, Rowe, A, Rowland, A, Rowland, J, Roy, K, Roy, M, Rudan, I, Russell, R, Russell, E, Saalmink, G, Sabit, R, Sage, E K, Samakomva, T, Samani, N, Sampson, C, Samuel, K, Samuel, R, Sanderson, A, Sapey, E, Saralaya, D, Sargant, J, Sarginson, C, Sass, T, Sattar, N, Saunders, K, Saunders, P, Saunders, L C, Savill, H, Saxon, W, Sayer, A, Schronce, J, Schwaeble, W, Scott, K, Selby, N, Sewell, T A, Shah, K, Shah, P, Shankar-Hari, M, Sharma, M, Sharpe, C, Sharpe, M, Shashaa, S, Shaw, A, Shaw, K, Shaw, V, Shelton, S, Shenton, L, Shevket, K, Short, J, Siddique, S, Siddiqui, S, Sidebottom, J, Sigfrid, L, Simons, G, Simpson, J, Simpson, N, Singh, C, Singh, S, Sissons, D, Skeemer, J, Slack, K, Smith, A, Smith, D, Smith, S, Smith, J, Smith, L, Soares, M, Solano, T S, Solly, R, Solstice, AR, Soulsby, T, Southern, D, Sowter, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steele, N, Steiner, M, Stensel, D, Stephens, G, Stephenson, L, Stern, M, Stewart, I, Stimpson, R, Stockdale, S, Stockley, J, Stoker, W, Stone, R, Storrar, W, Storrie, A, Storton, K, Stringer, E, Strong-Sheldrake, S, Stroud, N, Subbe, C, Sudlow, C L, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Tarusan, L, Tavoukjian, V, Taylor, A, Taylor, C, Taylor, J, Te, A, Tedd, H, Tee, CJ, Teixeira, J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thamu, B, Thickett, D, Thomas, C, Thomas, S, Thomas, A K, Thomas-Woods, T, Thompson, T, Thompson, A A R, Thornton, T, Tilley, J, Tinker, N, Tiongson, G F, Tobin, M, Tomlinson, J, Tong, C, Touyz, R, Tripp, K A, Tunnicliffe, E, Turnbull, A, Turner, E, Turner, S, Turner, V, Turner, K, Turney, S, Turtle, L, Turton, H, Ugoji, J, Ugwuoke, R, Upthegrove, R, Valabhji, J, Ventura, M, Vere, J, Vickers, C, Vinson, B, Wade, E, Wade, P, Wainwright, T, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, J A, Walsh, S, Warburton, L, Ward, T J C, Warwick, K, Wassall, H, Waterson, S, Watson, E, Watson, L, Watson, J, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Weston, H, Wheeler, H, White, S, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Whitworth, V, Wight, A, Wild, J, Wilkins, M, Wilkinson, D, Williams, N, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Willoughby, J, Wilson, A, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Wood, C, Woodhead, F, Woods, J, Wormleighton, J, Worsley, J, Wraith, D, Wrey Brown, C, Wright, C, Wright, L, Wright, S, Wyles, J, Wynter, I, Xu, M, Yasmin, N, Yasmin, S, Yates, T, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Zawia, A, Zeidan, L, Zhao, B, and Zongo, O

Published
2022
Full Text
View/download PDF

10. Structural Predictors of Lung Function Decline in the British Early COPD Network (BEACON) Cohort

Author

Ritchie, A.I., primary, Hoffman, E.A., additional, Allinson, J.P., additional, Bloom, C.I., additional, Bolton, C.E.R., additional, Choudhury, G., additional, Gerard, S.E., additional, Guo, J., additional, Alves-Moreira, L., additional, Mcgarvey, L., additional, Sapey, E., additional, Stockley, R.A., additional, Vestbo, J., additional, Singh, D., additional, Yip, K.P., additional, Wilkinson, T., additional, Mullerova, H., additional, Ostridge, K., additional, Mezzi, K., additional, Jöns, O., additional, Bucchioni, E., additional, Calverley, P.M., additional, Compton, C., additional, Jones, P.W., additional, and Wedzicha, J.A., additional

Published
2024
Full Text
View/download PDF

11. Small Airways Response to Bronchodilators in Adults with Asthma or COPD: A Systematic Review

Author

Almeshari MA, Alobaidi NY, Sapey E, Usmani O, Stockley RA, and Stockley JA

Subjects
asthma, copd, bronchodilator, reversibility, small airways function., Diseases of the respiratory system, RC705-779
Abstract

Mohammed A Almeshari,1,2 Nowaf Y Alobaidi,1,3 Elizabeth Sapey,1,4 Omar Usmani,5 Robert A Stockley,6 James A Stockley7 1Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK; 2Rehabilitation Health Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 3Respiratory Therapy Department, King Saud Bin Abdulaziz University for Health Sciences, Alahsa, Saudi Arabia; 4Acute Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK; 5Imperial College of London, London, UK; 6Department of Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; 7Lung Function & Sleep Department, Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UKCorrespondence: Mohammed A AlmeshariRehabilitation Health Science Department, College of Applied Medical Sciences, King Saud University, P. Box 145111,, Riyadh, ZIP 4545, Saudi ArabiaTel +966 50 8033 880Email malmeshari@ksu.edu.saBackground: Bronchodilator responsiveness (BDR) is commonly used in the diagnosis of lung disease. Although small airways dysfunction is a feature of asthma and COPD, physiological tests of small airways are not included in guidelines for BDR testing. This systematic review assessed the current evidence of BDR using small airways function in asthma and COPD.Methods: The systematic review used standard methodology with the protocol prospectively registered on PROSPERO (CRD42020164140). Electronic medical databases (EMBASE and Medline) were searched using related keywords. Abstracts and full texts were screened independently by two reviewers. Studies that reported the change of physiological small airways function and FEV1 were included in the review. The revised Cochrane risk of bias tool for RCT and NIH quality assessment tool for cohort and cross-sectional studies were used to evaluate the studies.Results: A total of 934 articles were identified, with 12 meeting the inclusion criteria. Ten studies included asthma patients, 1 study included COPD patients and 1 study included both asthma and COPD. A total of 1104 participants were included, of whom 941 were asthmatic, 64 had COPD and 109 were healthy controls. Studies were heterogeneous in design including the device, dose and time intervals for BDR assessment. A small airway BDR was seen for most tests in asthma and COPD, including oscillometry (R5-20, reactance (X5), area of reactance (AX) and resonant frequency (Fres)) and Maximal Mid Expiratory Flow.Conclusion: There is a measurable BDR in the small airways. However, with no consensus on how to assess BDR, studies were heterogeneous. Further research is needed to inform how BDR should be assessed, its clinical impact and place in routine clinical practice.Keywords: asthma, COPD, bronchodilator, reversibility, small airways function

Published
2021

12. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Author

Abel, K, Adamali, H, Adeloye, D, Adeyemi, O, Adeyemi, F, Ahmad, S, Ahmed, R, Ainsworth, M, Al-Sheklly, B, Alamoudi, A, Aljaroof, M, Allan, L, Allen, R, Alli, A, Altmann, D, Anderson, D, Andrews, M, Angyal, A, Antoniades, C, Arbane, G, Armour, C, Armstrong, N, Armstrong, L, Arnold, H, Arnold, D, Ashworth, M, Ashworth, A, Assefa-Kebede, H, Atkin, P, Atkins, H, Atkins, A, Aul, R, Avram, C, Baggott, R, Baguley, D, Baillie, J K, Bain, S, Bakali, M, Bakau, M, Baldry, E, Baldwin, D, Ballard, C, Bambrough, J, Barker, R E, Barratt, S, Barrett, F, Basire, D, Basu, N, Batterham, R, Baxendale, H, Bayes, H, Bayley, M, Beadsworth, M, Beirne, P, Bell, R, Bell, D, Berry, C, Betts, S, Bhui, K, Bishop, L, Blaikely, J, Bloomfield, C, Bloss, A, Bolger, A, Bolton, C E, Bonnington, J, Botkai, A, Bourne, M, Bourne, C, Bradley, E, Bramham, K, Brear, L, Breen, G, Breeze, J, Briggs, A, Bright, E, Brightling, C E, Brill, S, Brindle, K, Broad, L, Broome, M, Brown, J S, Brown, M, Brown, J, Brown, R, Brown, V, Brown, A, Brugha, T, Brunskill, N, Buch, M, Bularga, A, Bullmore, E, Burn, D, Burns, G, Busby, J, Buttress, A, Byrne, S, Cairns, P, Calder, P C, Calvelo, E, Card, B, Carr, L, Carson, G, Carter, P, Cavanagh, J, Chalder, T, Chalmers, J D, Chambers, R C, Channon, K, Chapman, K, Charalambou, A, Chaudhuri, N, Checkley, A, Chen, J, Chetham, L, Chilvers, E R, Chinoy, H, Chong-James, K, Choudhury, N, Choudhury, G, Chowdhury, P, Chowienczyk, P, Christie, C, Clark, D, Clark, C, Clarke, J, Clift, P, Clohisey, S, Coburn, Z, Cole, J, Coleman, C, Connell, D, Connolly, B, Connor, L, Cook, A, Cooper, B, Coupland, C, Craig, T, Crisp, P, Cristiano, D, Crooks, M G, Cross, A, Cruz, I, Cullinan, P, Daines, L, Dalton, M, Dark, P, Dasgin, J, David, A, David, C, Davies, M, Davies, G, Davies, K, Davies, F, Davies, G A, Daynes, E, De Silva, T, De Soyza, A, Deakin, B, Deans, A, Defres, S, Dell, A, Dempsey, K, Dennis, J, Dewar, A, Dharmagunawardena, R, Diar Bakerly, N, Dipper, A, Diver, S, Diwanji, S N, Dixon, M, Djukanovic, R, Dobson, H, Dobson, C, Dobson, S L, Docherty, A B, Donaldson, A, Dong, T, Dormand, N, Dougherty, A, Dowling, R, Drain, S, Dulawan, P, Dunleavy, A, Dunn, S, Easom, N, Echevarria, C, Edwards, S, Edwardson, C, Elliott, B, Elliott, A, Ellis, Y, Elmer, A, Elneima, O, Evans, R A, Evans, J, Evans, H, Evans, D, Evans, R I, Evans, R, Evans, T, Fabbri, L, Fairbairn, S, Fairman, A, Fallon, K, Faluyi, D, Favager, C, Felton, T, Finch, J, Finney, S, Fisher, H, Fletcher, S, Flockton, R, Foote, D, Ford, A, Forton, D, Francis, R, Francis, S, Francis, C, Frankel, A, Fraser, E, Free, R, French, N, Fuld, J, Furniss, J, Garner, L, Gautam, N, Geddes, J R, George, P M, George, J, Gibbons, M, Gilmour, L, Gleeson, F, Glossop, J, Glover, S, Goodman, N, Gooptu, B, Gorsuch, T, Gourlay, E, Greenhaff, P, Greenhalf, W, Greenhalgh, A, Greening, N J, Greenwood, J, Greenwood, S, Gregory, R, Grieve, D, Gummadi, M, Gupta, A, Gurram, S, Guthrie, E, Hadley, K, Haggar, A, Hainey, K, Haldar, P, Hall, I, Hall, L, Halling-Brown, M, Hamil, R, Hanley, N A, Hardwick, H E, Hardy, E, Hargadon, B, Harrington, K, Harris, V, Harrison, E M, Harrison, P, Hart, N, Harvey, A, Harvey, M, Harvie, M, Havinden-Williams, M, Hawkes, J, Hawkings, N, Haworth, J, Hayday, A, Heaney, L G, Heeney, J L, Heightman, M, Heller, S, Henderson, M, Hesselden, L, Hillman, T, Hingorani, A, Hiwot, T, Ho, L P, Hoare, A, Hoare, M, Hogarth, P, Holbourn, A, Holdsworth, L, Holgate, D, Holmes, K, Holroyd-Hind, B, Horsley, A, Hosseini, A, Hotopf, M, Houchen, L, Howard, L, Howell, A, Hufton, E, Hughes, A, Hughes, J, Hughes, R, Humphries, A, Huneke, N, Hurst, J R, Hurst, R, Husain, M, Hussell, T, Ibrahim, W, Ient, A, Ingram, L, Ismail, K, Jackson, T, Jacob, J, James, W Y, Janes, S, Jarvis, H, Jayaraman, B, Jenkins, R G, Jezzard, P, Jiwa, K, Johnson, S, Johnson, C, Johnston, D, Jolley, C, Jolley, C J, Jones, I, Jones, S, Jones, D, Jones, H, Jones, G, Jones, M, Jose, S, Kabir, T, Kaltsakas, G, Kamwa, V, Kar, P, Kausar, Z, Kelly, S, Kerr, S, Key, A L, Khan, F, Khunti, K, King, C, King, B, Kitterick, P, Klenerman, P, Knibbs, L, Knight, S, Knighton, A, Kon, O M, Kon, S, Kon, S S, Korszun, A, Kotanidis, C, Koychev, I, Kurupati, P, Kwan, J, Laing, C, Lamlum, H, Landers, G, Langenberg, C, Lasserson, D, Lawrie, A, Lea, A, Leavy, O C, Lee, D, Lee, E, Leitch, K, Lenagh, R, Lewis, K, Lewis, V, Lewis, K E, Lewis, J, Lewis-Burke, N, Light, T, Lightstone, L, Lim, L, Linford, S, Lingford-Hughes, A, Lipman, M, Liyanage, K, Lloyd, A, Logan, S, Lomas, D, Lone, N I, Loosley, R, Lord, J M, Lota, H, Lucey, A, MacGowan, G, Macharia, I, Mackay, C, Macliver, L, Madathil, S, Madzamba, G, Magee, N, Mairs, N, Majeed, N, Major, E, Malim, M, Mallison, G, Man, W, Mandal, S, Mangion, K, Mansoori, P, Marciniak, S, Mariveles, M, Marks, M, Marshall, B, Martineau, A, Maskell, N, Matila, D, Matthews, L, Mayet, J, McAdoo, S, McAllister-Williams, H, McArdle, P, McArdle, A, McAulay, D, McAuley, H J C, McAuley, D F, McCafferty, K, McCann, G P, McCauley, H, McCourt, P, Mcgarvey, L, McGinness, J, McGovern, A, McGuinness, H, McInnes, I B, McIvor, K, McIvor, E, McMahon, A, McMahon, M J, McMorrow, L, Mcnally, T, McNarry, M, McQueen, A, McShane, H, Megson, S, Meiring, J, Menzies, D, Michael, A, Michael, B D, Milligan, L, Mills, N, Mitchell, J, Mohamed, A, Molyneaux, P L, Monteiro, W, Morley, A, Morrison, L, Morriss, R, Morrow, A, Moss, A, Moss, A J, Moss, P, Mukaetova-Ladinska, E, Munawar, U, Murali, E, Murira, J, Nassa, H, Neill, P, Neubauer, S, Newby, D, Newell, H, Newton Cox, A, Nicholson, T, Nicoll, D, Nolan, C M, Noonan, M J, Novotny, P, Nunag, J, Nyaboko, J, O'Brien, L, Odell, N, Ogg, G, Olaosebikan, O, Oliver, C, Omar, Z, Openshaw, P J M, Osbourne, R, Ostermann, M, Overton, C, Oxton, J, Pacpaco, E, Paddick, S, Papineni, P, Paradowski, K, Pareek, M, Parekh, D, Parfrey, H, Pariante, C, Parker, S, Parkes, M, Parmar, J, Parvin, R, Patale, S, Patel, B, Patel, S, Patel, M, Pathmanathan, B, Pavlides, M, Pearl, J E, Peckham, D, Pendlebury, J, Peng, Y, Pennington, C, Peralta, I, Perkins, E, Peto, T, Petousi, N, Petrie, J, Pfeffer, P, Phipps, J, Pimm, J, Piper Hanley, K, Pius, R, Plein, S, Plekhanova, T, Poinasamy, K, Polgar, O, Poll, L, Porter, J C, Portukhay, S, Powell, N, Price, L, Price, D, Price, A, Price, C, Prickett, A, Quaid, S, Quigley, J, Quint, J, Qureshi, H, Rahman, N, Rahman, M, Ralser, M, Raman, B, Ramos, A, Rangeley, J, Rees, T, Regan, K, Richards, A, Richardson, M, Rivera-Ortega, P, Robertson, E, Rodgers, J, Ross, G, Rossdale, J, Rostron, A, Routen, A, Rowland, A, Rowland, M J, Rowland, J, Rowland-Jones, S L, Roy, K, Rudan, I, Russell, R, Russell, E, Sabit, R, Sage, E K, Samani, N, Samuel, R, Sapey, E, Saralaya, D, Saratzis, A, Sargeant, J, Sass, T, Sattar, N, Saunders, K, Saunders, R, Saxon, W, Sayer, A, Schwaeble, W, Scott, J, Scott, K, Selby, N, Semple, M G, Sereno, M, Shah, K, Shah, A, Shah, P, Sharma, M, Sharpe, M, Sharpe, C, Shaw, V, Sheikh, A, Shevket, K, Shikotra, A, Short, J, Siddiqui, S, Sigfrid, L, Simons, G, Simpson, J, Singapuri, A, Singh, S J, Singh, C, Singh, S, Skeemer, J, Smith, I, Smith, J, Smith, L, Smith, A, Soares, M, Southern, D, Spears, M, Spencer, L G, Speranza, F, Stadon, L, Stanel, S, Steiner, M, Stensel, D, Stern, M, Stewart, I, Stockley, J, Stone, R, Storrie, A, Storton, K, Stringer, E, Subbe, C, Sudlow, C, Suleiman, Z, Summers, C, Summersgill, C, Sutherland, D, Sykes, D L, Sykes, R, Talbot, N, Tan, A L, Taylor, C, Taylor, A, Te, A, Tedd, H, Tee, C J, Tench, H, Terry, S, Thackray-Nocera, S, Thaivalappil, F, Thickett, D, Thomas, D, Thomas, D C, Thomas, A K, Thompson, A A R, Thompson, T, Thornton, T, Thwaites, R S, Tobin, M, Toingson, G F, Tong, C, Toshner, M, Touyz, R, Tripp, K A, Tunnicliffe, E, Turner, E, Turtle, L, Turton, H, Ugwuoke, R, Upthegrove, R, Valabhji, J, Vellore, K, Wade, E, Wain, L V, Wajero, L O, Walder, S, Walker, S, Wall, E, Wallis, T, Walmsley, S, Walsh, S, Walsh, J A, Watson, L, Watson, J, Watson, E, Welch, C, Welch, H, Welsh, B, Wessely, S, West, S, Wheeler, H, Whitehead, V, Whitney, J, Whittaker, S, Whittam, B, Wild, J, Wilkins, M, Wilkinson, D, Williams, N, Williams, B, Williams, J, Williams-Howard, S A, Willicombe, M, Willis, G, Wilson, D, Wilson, I, Window, N, Witham, M, Wolf-Roberts, R, Woodhead, F, Woods, J, Wootton, D, Worsley, J, Wraith, D, Wright, L, Wright, C, Wright, S, Xie, C, Yasmin, S, Yates, T, Yip, K P, Young, B, Young, S, Young, A, Yousuf, A J, Yousuf, A, Zawia, A, Zhao, B, Zongo, O, Evans, Rachael A, McAuley, Hamish J C, Harrison, Ewen M, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Elneima, Omer, Docherty, Annemarie B, Lone, Nazir I, Leavy, Olivia C, Daines, Luke, Baillie, J Kenneth, Brown, Jeremy S, Chalder, Trudie, De Soyza, Anthony, Diar Bakerly, Nawar, Easom, Nicholas, Geddes, John R, Greening, Neil J, Hart, Nick, Heaney, Liam G, Heller, Simon, Howard, Luke, Hurst, John R, Jacob, Joseph, Jenkins, R Gisli, Jolley, Caroline, Kerr, Steven, Kon, Onn M, Lewis, Keir, Lord, Janet M, McCann, Gerry P, Neubauer, Stefan, Openshaw, Peter J M, Parekh, Dhruv, Pfeffer, Paul, Rahman, Najib M, Raman, Betty, Richardson, Matthew, Rowland, Matthew, Semple, Malcolm G, Shah, Ajay M, Singh, Sally J, Sheikh, Aziz, Thomas, David, Toshner, Mark, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Wain, Louise V, and Brightling, Christopher E

Published
2021
Full Text
View/download PDF

15. Long COVID research: an update from the PHOSP-COVID Scientific Summit

Author

Brightling, Christopher E, primary, Evans, Rachael A, additional, Singapuri, Amisha, additional, Smith, Nikki, additional, Wain, Louise V, additional, Brightling, C E, additional, Evans, R A, additional, Wain, L V, additional, Chalmers, J D, additional, Harris, V C, additional, Ho, L P, additional, Horsley, A, additional, Houchen-Wolloff, L, additional, Marks, M, additional, Raman, B, additional, Singapuri, A, additional, Barran, P, additional, Bingham, M, additional, Chilvers, E R, additional, Daynes, E, additional, Efstathiou, C M, additional, Elneima, O, additional, Guillen Guio, B, additional, Harrison, E M, additional, Jenkins, R G, additional, Liew, F, additional, Lone, N I, additional, Lord, J M, additional, McAuley, H J C, additional, McCann, G P, additional, Mitchell, J, additional, Plekhanova, T, additional, Russell, R J, additional, Saunders, R M, additional, Semple, M G, additional, Smith, N, additional, Trivedi, D, additional, Turtle, L, additional, Walker, S, additional, Abel, K, additional, Adamali, H, additional, Adeloye, D, additional, Adeyemi, O, additional, Adrego, R, additional, Aguilar Jimenez, L A, additional, Ahmad, S, additional, Ahmad Haider, N, additional, Ahmed, R, additional, Ahwireng, N, additional, Ainsworth, M, additional, Al-Sheklly, B, additional, Alamoudi, A, additional, Ali, M, additional, Aljaroof, M, additional, Allan, L, additional, Allen, R J, additional, Allerton, L, additional, Allsop, L, additional, Allt, AM, additional, Almeida, P, additional, Altmann, D, additional, Alvarez Corral, M, additional, Amoils, S, additional, Anderson, D, additional, Antoniades, C, additional, Arbane, G, additional, Arias, A, additional, Armour, C, additional, Armstrong, L, additional, Armstrong, N, additional, Arnold, D, additional, Arnold, H, additional, Ashish, A, additional, Ashworth, A, additional, Ashworth, M, additional, Aslani, S, additional, Assefa-Kebede, H, additional, Atkin, P, additional, Atkin, C, additional, Aul, R, additional, Aung, H, additional, Austin, L, additional, Avram, C, additional, Ayoub, A, additional, Babores, M, additional, Baggott, R, additional, Bagshaw, J, additional, Baguley, D, additional, Bailey, L, additional, Baillie, J K, additional, Bain, S, additional, Bakali, M, additional, Bakau, M, additional, Baldry, E, additional, Baldwin, M, additional, Baldwin, D, additional, Ballard, C, additional, Banerjee, A, additional, Bang, D, additional, Barker, R E, additional, Barman, L, additional, Barratt, S, additional, Barrett, F, additional, Basire, D, additional, Basu, N, additional, Bates, M, additional, Bates, A, additional, Batterham, R, additional, Baxendale, H, additional, Baxter, G, additional, Bayes, H, additional, Beadsworth, M, additional, Beckett, P, additional, Beggs, M, additional, Begum, M, additional, Beirne, P, additional, Bell, M, additional, Bell, R, additional, Bennett, K, additional, Beranova, E, additional, Bermperi, A, additional, Berridge, A, additional, Berry, C, additional, Betts, S, additional, Bevan, E, additional, Bhui, K, additional, Birchall, K, additional, Bishop, L, additional, Bisnauthsing, K, additional, Blaikely, J, additional, Bloss, A, additional, Bolger, A, additional, Bolton, C E, additional, Bonnington, J, additional, Botkai, A, additional, Bourne, C, additional, Bourne, M, additional, Bramham, K, additional, Brear, L, additional, Breen, G, additional, Breeze, J, additional, Breeze, K, additional, Briggs, A, additional, Bright, E, additional, Brill, S, additional, Brindle, K, additional, Broad, L, additional, Broadley, A, additional, Brookes, C, additional, Broome, M, additional, Brown, V, additional, Brown, M, additional, Brown, J, additional, Brown, A, additional, Brown, J S, additional, Brugha, T, additional, Brunskill, N, additional, Buch, M, additional, Buckley, P, additional, Bularga, A, additional, Bullmore, E, additional, Bunker, J, additional, Burden, L, additional, Burdett, T, additional, Burn, D, additional, Burns, G, additional, Burns, A, additional, Busby, J, additional, Butcher, R, additional, Butt, A, additional, Byrne, S, additional, Cairns, P, additional, Calder, P C, additional, Calvelo, E, additional, Carborn, H, additional, Card, B, additional, Carr, C, additional, Carr, L, additional, Carson, G, additional, Carter, P, additional, Casey, A, additional, Cassar, M, additional, Cavanagh, J, additional, Chablani, M, additional, Chalder, T, additional, Chambers, R C, additional, Chan, F, additional, Channon, K M, additional, Chapman, K, additional, Charalambou, A, additional, Chaudhuri, N, additional, Checkley, A, additional, Chen, J, additional, Cheng, Y, additional, Chetham, L, additional, Childs, C, additional, Chinoy, H, additional, Chiribiri, A, additional, Chong-James, K, additional, Choudhury, N, additional, Choudhury, G, additional, Chowienczyk, P, additional, Christie, C, additional, Chrystal, M, additional, Clark, C, additional, Clark, D, additional, Clarke, J, additional, Clohisey, S, additional, Coakley, G, additional, Coburn, Z, additional, Coetzee, S, additional, Cole, J, additional, Coleman, C, additional, Conneh, F, additional, Connell, D, additional, Connolly, B, additional, Connor, L, additional, Cook, A, additional, Cooper, S, additional, Cooper, B, additional, Cooper, J, additional, Copeland, D, additional, Cosier, T, additional, Coulding, M, additional, Coupland, C, additional, Cox, E, additional, Craig, T, additional, Crisp, P, additional, Cristiano, D, additional, Crooks, M G, additional, Cross, A, additional, Cruz, I, additional, Cullinan, P, additional, Cuthbertson, D, additional, Daines, L, additional, Dalton, M, additional, Daly, P, additional, Daniels, A, additional, Dark, P, additional, Dasgin, J, additional, David, C, additional, David, A, additional, Davies, F, additional, Davies, E, additional, Davies, K, additional, Davies, G, additional, Davies, G A, additional, Davies, M J, additional, Dawson, J, additional, Dawson, C, additional, De Soyza, A, additional, Deakin, B, additional, Deans, A, additional, Deas, C, additional, Deery, J, additional, Defres, S, additional, Dell, A, additional, Dempsey, K, additional, Denneny, E, additional, Dennis, J, additional, Dewar, A, additional, Dharmagunawardena, R, additional, Diar-Bakerly, N, additional, Dickens, C, additional, Dipper, A, additional, Diver, S, additional, Diwanji, S N, additional, Dixon, M, additional, Djukanovic, R, additional, Dobson, H, additional, Dobson, S L, additional, Docherty, A B, additional, Donaldson, A, additional, Dong, T, additional, Dormand, N, additional, Dougherty, A, additional, Dowling, R, additional, Drain, S, additional, Draxlbauer, K, additional, Drury, K, additional, Dulawan, P, additional, Dunleavy, A, additional, Dunn, S, additional, Dupont, C, additional, Earley, J, additional, Easom, N, additional, Echevarria, C, additional, Edwards, S, additional, Edwardson, C, additional, El-Taweel, H, additional, Elliott, A, additional, Elliott, K, additional, Ellis, Y, additional, Elmer, A, additional, Evans, T, additional, Evans, R I, additional, Evans, D, additional, Evans, R, additional, Evans, H, additional, Evans, J, additional, Evenden, C, additional, Evison, L, additional, Fabbri, L, additional, Fairbairn, S, additional, Fairman, A, additional, Fallon, K, additional, Faluyi, D, additional, Favager, C, additional, Fayzan, T, additional, Featherstone, J, additional, Felton, T, additional, Ferreira, V, additional, Finch, J, additional, Finney, S, additional, Finnigan, J, additional, Finnigan, L, additional, Fisher, H, additional, Fletcher, S, additional, Flockton, R, additional, Flynn, M, additional, Foot, H, additional, Foote, D, additional, Ford, A, additional, Forton, D, additional, Fraile, E, additional, Francis, C, additional, Francis, R, additional, Francis, S, additional, Frankel, A, additional, Fraser, E, additional, Free, R, additional, French, N, additional, Fu, X, additional, Fuld, J, additional, Furniss, J, additional, Garner, L, additional, Gautam, N, additional, Geddes, J R, additional, George, J, additional, George, P, additional, Gibbons, M, additional, Gill, R, additional, Gill, M, additional, Gilmour, L, additional, Gleeson, F, additional, Glossop, J, additional, Glover, S, additional, Goodman, N, additional, Goodwin, C, additional, Gooptu, B, additional, Gordon, H, additional, Gorsuch, T, additional, Greatorex, M, additional, Greenhaff, P L, additional, Greenhalf, W, additional, Greenhalgh, A, additional, Greening, N J, additional, Greenwood, J, additional, Gregory, R, additional, Gregory, H, additional, Grieve, D, additional, Griffin, D, additional, Griffiths, L, additional, Guerdette, A-M, additional, Gummadi, M, additional, Gupta, A, additional, Gurram, S, additional, Guthrie, E, additional, Guy, Z, additional, Hadley, K, additional, Haggar, A, additional, Hainey, K, additional, Hairsine, B, additional, Haldar, P, additional, Hall, L, additional, Hall, I, additional, Halling-Brown, M, additional, Hamil, R, additional, Hancock, A, additional, Hancock, K, additional, Hanley, N A, additional, Haq, S, additional, Hardwick, H E, additional, Hardy, T, additional, Hardy, E, additional, Hargadon, B, additional, Harrington, K, additional, Harris, E, additional, Harrison, P, additional, Hart, N, additional, Harvey, A, additional, Harvey, M, additional, Harvie, M, additional, Haslam, L, additional, Hastie, C, additional, Havinden-Williams, M, additional, Hawkes, J, additional, Hawkings, N, additional, Haworth, J, additional, Hayday, A, additional, Haynes, M, additional, Hazeldine, J, additional, Hazelton, T, additional, Heaney, L G, additional, Heeley, C, additional, Heeney, J L, additional, Heightman, M, additional, Heller, S, additional, Henderson, M, additional, Henson, H, additional, Hesselden, L, additional, Hewitt, M, additional, Highett, V, additional, Hillman, T, additional, Hiwot, T, additional, Hoare, M, additional, Hoare, A, additional, Hockridge, J, additional, Hogarth, P, additional, Holbourn, A, additional, Holden, S, additional, Holdsworth, L, additional, Holgate, D, additional, Holland, M, additional, Holloway, L, additional, Holmes, K, additional, Holmes, M, additional, Holroyd-Hind, B, additional, Holt, L, additional, Hormis, A, additional, Hosseini, A, additional, Hotopf, M, additional, Howard, L S, additional, Howard, K, additional, Howell, A, additional, Hufton, E, additional, Hughes, R A, additional, Hughes, J, additional, Hughes, A D, additional, Humphries, A, additional, Huneke, N, additional, Hurditch, E, additional, Hurst, J, additional, Husain, M, additional, Hussell, T, additional, Hutchinson, J, additional, Ibrahim, W, additional, Ilyas, F, additional, Ingham, J, additional, Ingram, L, additional, Ionita, D, additional, Isaacs, K, additional, Ismail, K, additional, Jackson, T, additional, Jacob, J, additional, James, W Y, additional, Jang, W, additional, Jarman, C, additional, Jarrold, I, additional, Jarvis, H, additional, Jastrub, R, additional, Jayaraman, B, additional, Jezzard, P, additional, Jiwa, K, additional, Johnson, C, additional, Johnson, S, additional, Johnston, D, additional, Jolley, C J, additional, Jones, S, additional, Jones, H, additional, Jones, L, additional, Jones, I, additional, Jones, G, additional, Jones, M G, additional, Jones, D, additional, Jose, S, additional, Kabir, T, additional, Kaltsakas, G, additional, Kamwa, V, additional, Kanellakis, N, additional, Kaprowska, S, additional, Kausar, Z, additional, Keenan, N, additional, Kelly, S, additional, Kemp, G, additional, Kerr, S, additional, Kerslake, H, additional, Key, A L, additional, Khan, F, additional, Khunti, K, additional, Kilroy, S, additional, King, B, additional, King, C, additional, Kingham, L, additional, Kirk, J, additional, Kitterick, P, additional, Klenerman, P, additional, Knibbs, L, additional, Knight, S, additional, Knighton, A, additional, Kon, O, additional, Kon, S, additional, Kon, S S, additional, Korszun, A, additional, Koychev, I, additional, Kurasz, C, additional, Kurupati, P, additional, Laing, C, additional, Lamlum, H, additional, Landers, G, additional, Langenberg, C, additional, Lavelle-Langham, L, additional, Lawrie, A, additional, Lawson, C, additional, Layton, A, additional, Lea, A, additional, Leavy, O C, additional, Lee, J-H, additional, Lee, E, additional, Lee, D, additional, Leitch, K, additional, Lenagh, R, additional, Lewis, V, additional, Lewis, J, additional, Lewis, K E, additional, Lewis, D, additional, Lewis-Burke, N, additional, Li, X, additional, Light, T, additional, Lightstone, L, additional, Lilaonitkul, W, additional, Lim, L, additional, Linford, S, additional, Lingford-Hughes, A, additional, Lipman, M, additional, Liyanage, K, additional, Lloyd, A, additional, Logan, S, additional, Lomas, D, additional, Loosley, R, additional, Lota, H, additional, Lovegrove, W, additional, Lucey, A, additional, Lucy, L, additional, Lukaschuk, E, additional, Lye, A, additional, Lynch, C, additional, MacDonald, S, additional, MacGowan, G, additional, Macharia, I, additional, Mackie, J, additional, Macliver, L, additional, Madathil, S, additional, Madzamba, G, additional, Magee, N, additional, Magtoto, M M, additional, Mairs, N, additional, Majeed, N, additional, Major, E, additional, Malein, F, additional, Malim, M, additional, Mallison, G, additional, Man, W D-C, additional, Mandal, S, additional, Mangion, K, additional, Manisty, C, additional, Manley, R, additional, March, K, additional, Marciniak, S, additional, Marino, P, additional, Mariveles, M, additional, Marouzet, E, additional, Marsh, S, additional, Marshall, M, additional, Marshall, B, additional, Martin, J, additional, Martineau, A, additional, Martinez, L M, additional, Maskell, N, additional, Matila, D, additional, Matimba-Mupaya, W, additional, Matthews, L, additional, Mbuyisa, A, additional, McAdoo, S, additional, McAllister-Williams, H, additional, McArdle, P, additional, McArdle, A, additional, McAulay, D, additional, McCormick, W, additional, McCormick, J, additional, McCourt, P, additional, McCracken, C, additional, McGarvey, L, additional, McGee, C, additional, Mcgee, K, additional, McGinness, J, additional, McGlynn, K, additional, McGovern, A, additional, McGuinness, H, additional, McInnes, I B, additional, McIntosh, J, additional, McIvor, E, additional, McIvor, K, additional, McLeavey, L, additional, McMahon, A, additional, McMahon, M J, additional, McMorrow, L, additional, Mcnally, T, additional, McNarry, M, additional, McNeill, J, additional, McQueen, A, additional, McShane, H, additional, Mears, C, additional, Megson, C, additional, Megson, S, additional, Mehta, P, additional, Meiring, J, additional, Melling, L, additional, Mencias, M, additional, Menke, R, additional, Menzies, D, additional, Merida Morillas, M, additional, Michael, A, additional, Michael, B, additional, Miller, C A, additional, Milligan, L, additional, Mills, N L, additional, Mills, C, additional, Mills, G, additional, Milner, L, additional, Misra, S, additional, Mohamed, A, additional, Mohamed, N, additional, Mohammed, S, additional, Molyneaux, P L, additional, Monteiro, W, additional, Moriera, S, additional, Morley, A, additional, Morrison, L, additional, Morriss, R, additional, Morrow, A, additional, Moss, P, additional, Moss, A J, additional, Motohashi, K, additional, Msimanga, N, additional, Mukaetova-Ladinska, E, additional, Munawar, U, additional, Murira, J, additional, Nanda, U, additional, Nassa, H, additional, Nasseri, M, additional, Nathu, R, additional, Neal, A, additional, Needham, R, additional, Neill, P, additional, Neubauer, S, additional, Newby, D E, additional, Newell, H, additional, Newman, J, additional, Newman, T, additional, Newton-Cox, A, additional, Nichols, T E, additional, Nicholson, T, additional, Nicolaou, C, additional, Nicoll, D, additional, Nikolaidis, A, additional, Nikolaidou, C, additional, Nolan, C M, additional, Noonan, M J, additional, Norman, C, additional, Novotny, P, additional, Nunag, J L, additional, Nwafor, L, additional, Nwanguma, U, additional, Nyaboko, J, additional, O'Brien, C, additional, O'Donnell, K, additional, O'Regan, D P, additional, O'Brien, L, additional, Odell, N, additional, Ogbole, G, additional, Ogg, G, additional, Olaosebikan, O, additional, Oliver, C, additional, Omar, Z, additional, Openshaw, P J M, additional, Orriss-Dib, L, additional, Osborne, L, additional, Osbourne, R, additional, Ostermann, M, additional, Overton, C, additional, Owen, J, additional, Oxton, J, additional, Pack, J, additional, Pacpaco, E, additional, Paddick, S, additional, Painter, S, additional, Pakzad, A, additional, Palmer, S, additional, Papineni, P, additional, Paques, K, additional, Paradowski, K, additional, Pareek, M, additional, Parekh, D, additional, Parfrey, H, additional, Pariante, C, additional, Parker, S, additional, Parkes, M, additional, Parmar, J, additional, Patale, S, additional, Patel, M, additional, Patel, B, additional, Patel, S, additional, Pattenadk, D, additional, Pavlides, M, additional, Payne, S, additional, Pearce, L, additional, Pearl, J E, additional, Peckham, D, additional, Pendlebury, J, additional, Peng, Y, additional, Pennington, C, additional, Peralta, I, additional, Perkins, E, additional, Peterkin, Z, additional, Peto, T, additional, Petousi, N, additional, Petrie, J, additional, Pfeffer, P, additional, Phipps, J, additional, Piechnik, S, additional, Pimm, J, additional, Piper Hanley, K, additional, Pius, R, additional, Plant, H, additional, Plein, S, additional, Plowright, M, additional, Poinasamy, K, additional, Polgar, O, additional, Poll, L, additional, Porter, J, additional, Porter, J C, additional, Portukhay, S, additional, Powell, N, additional, Prabhu, A, additional, Pratt, J, additional, Price, A, additional, Price, C, additional, Price, L, additional, Price, D, additional, Prickett, A, additional, Propescu, I, additional, Propescu, J, additional, Prosper, S, additional, Pugmire, S, additional, Quaid, S, additional, Quigley, J, additional, Quint, J, additional, Qureshi, H, additional, Qureshi, I N, additional, Radhakrishnan, K, additional, Rahman, N M, additional, Ralser, M, additional, Ramos, H, additional, Ramos, A, additional, Rangeley, J, additional, Rangelov, B, additional, Ratcliffe, L, additional, Ravencroft, P, additional, Reddington, A, additional, Reddy, R, additional, Reddy, A, additional, Redfearn, H, additional, Redwood, D, additional, Reed, A, additional, Rees, M, additional, Rees, T, additional, Regan, K, additional, Reynolds, W, additional, Ribeiro, C, additional, Richards, A, additional, Richardson, E, additional, Richardson, M, additional, Rivera-Ortega, P, additional, Roberts, K, additional, Robertson, E, additional, Robinson, L, additional, Robinson, E, additional, Roche, L, additional, Roddis, C, additional, Rodger, J, additional, Rogers, N, additional, Ross, G, additional, Ross, A, additional, Rossdale, J, additional, Rostron, A, additional, Rowe, A, additional, Rowland, J, additional, Rowland, M J, additional, Rowland, A, additional, Rowland-Jones, S L, additional, Roy, M, additional, Roy, K, additional, Rudan, I, additional, Russell, R, additional, Russell, E, additional, Saalmink, G, additional, Sabit, R, additional, Sage, E K, additional, Samakomva, T, additional, Samani, N, additional, Samat, A A, additional, Sampson, C, additional, Samuel, K, additional, Samuel, R, additional, Sanders, Z B, additional, Sanderson, A, additional, Sapey, E, additional, Saralaya, D, additional, Sargant, J, additional, Sarginson, C, additional, Sass, T, additional, Sattar, N, additional, Saunders, K, additional, Saunders, P, additional, Saunders, L C, additional, Savill, H, additional, Saxon, W, additional, Sayer, A, additional, Schronce, J, additional, Schwaeble, W, additional, Scott, J T, additional, Scott, K, additional, Selby, N, additional, Sereno, M, additional, Sewell, T A, additional, Shah, K, additional, Shah, A, additional, Shah, P, additional, Shankar-Hari, M, additional, Sharma, M, additional, Sharpe, C, additional, Sharpe, M, additional, Shashaa, S, additional, Shaw, A, additional, Shaw, V, additional, Shaw, K, additional, Sheikh, A, additional, Shelton, S, additional, Shenton, L, additional, Shevket, K, additional, Shikotra, A, additional, Short, J, additional, Siddique, S, additional, Siddiqui, S, additional, Sidebottom, J, additional, Sigfrid, L, additional, Simons, G, additional, Simpson, N, additional, Simpson, J, additional, Singh, S, additional, Singh, C, additional, Singh, S J, additional, Sissons, D, additional, Skeemer, J, additional, Slack, K, additional, Smith, D, additional, Smith, A, additional, Smith, J, additional, Smith, L, additional, Smith, S, additional, Soares, M, additional, Solano, T S, additional, Solly, R, additional, Solstice, AR, additional, Soulsby, T, additional, Southern, D, additional, Sowter, D, additional, Spears, M, additional, Spencer, L G, additional, Speranza, F, additional, Stadon, L, additional, Stanel, S, additional, Steeds, R, additional, Steele, N, additional, Steiner, M, additional, Stensel, D, additional, Stephens, G, additional, Stephenson, L, additional, Stern, M, additional, Stewart, I, additional, Stimpson, R, additional, Stockdale, S, additional, Stockley, J, additional, Stoker, W, additional, Stone, R, additional, Storrar, W, additional, Storrie, A, additional, Storton, K, additional, Stringer, E, additional, Strong-Sheldrake, S, additional, Stroud, N, additional, Subbe, C, additional, Sudlow, C L, additional, Suleiman, Z, additional, Summers, C, additional, Summersgill, C, additional, Sutherland, D, additional, Sykes, D L, additional, Sykes, R, additional, Talbot, N, additional, Tan, A L, additional, Tarusan, L, additional, Tavoukjian, V, additional, Taylor, J, additional, Taylor, A, additional, Taylor, C, additional, Taylor, J P, additional, Te, A, additional, Tedd, H, additional, Tee, CJ, additional, Teixeira, J, additional, Tench, H, additional, Terry, S, additional, Thackray-Nocera, S, additional, Thaivalappil, F, additional, Thamu, B, additional, Thickett, D, additional, Thomas, D C, additional, Thomas, S, additional, Thomas, C, additional, Thomas, A K, additional, Thomas-Woods, T, additional, Thompson, A A R, additional, Thompson, T, additional, Thornton, T, additional, Thorpe, M, additional, Thwaites, R S, additional, Tilley, J, additional, Tinker, N, additional, Tiongson, G F, additional, Tobin, M, additional, Tomlinson, J, additional, Tong, C, additional, Toshner, M, additional, Touyz, R, additional, Treibel, T, additional, Tripp, K A, additional, Tunnicliffe, E M, additional, Turnbull, A, additional, Turner, K, additional, Turner, S, additional, Turner, V, additional, Turner, E, additional, Turney, S, additional, Turton, H, additional, Ugoji, J, additional, Ugwuoke, R, additional, Upthegrove, R, additional, Valabhji, J, additional, Ventura, M, additional, Vere, J, additional, Vickers, C, additional, Vinson, B, additional, Vogiatzis, I, additional, Wade, E, additional, Wade, P, additional, Wainwright, T, additional, Wajero, L O, additional, Walder, S, additional, Wall, E, additional, Wallis, T, additional, Walmsley, S, additional, Walsh, S, additional, Walsh, J A, additional, Warburton, L, additional, Ward, T J C, additional, Warwick, K, additional, Wassall, H, additional, Waterson, S, additional, Watson, L, additional, Watson, E, additional, Watson, J, additional, Webster, M, additional, Weir McCall, J, additional, Welch, H, additional, Welch, C, additional, Welsh, B, additional, Wessely, S, additional, West, S, additional, Weston, H, additional, Wheeler, H, additional, White, S, additional, Whitehead, V, additional, Whitney, J, additional, Whittaker, S, additional, Whittam, B, additional, Whitworth, V, additional, Wight, A, additional, Wild, J M, additional, Wilkins, M, additional, Wilkinson, D, additional, Williams, N, additional, Williams, B, additional, Williams, J, additional, Williams-Howard, S A, additional, Willicombe, M, additional, Willis, G, additional, Willoughby, J, additional, Wilson, A, additional, Wilson, I, additional, Wilson, D, additional, Window, N, additional, Witham, M, additional, Wolf-Roberts, R, additional, Wood, C, additional, Woodhead, F, additional, Woods, J, additional, Wootton, D G, additional, Wormleighton, J, additional, Worsley, J, additional, Wraith, D, additional, Wrey Brown, C, additional, Wright, C, additional, Wright, S, additional, Wright, L, additional, Wyles, J, additional, Wynter, I, additional, Xie, C, additional, Xu, M, additional, Yasmin, N, additional, Yasmin, S, additional, Yates, T, additional, Yip, K P, additional, Young, S, additional, Young, B, additional, Young, A, additional, Yousuf, A J, additional, Zawia, A, additional, Zeidan, L, additional, Zhao, B, additional, Zheng, B, additional, and Zongo, O, additional

Published
2023
Full Text
View/download PDF

16. Small airways disease: time for a revisit?

Author

Stockley JA, Cooper BG, Stockley RA, and Sapey E

Subjects
Small Airways, Chronic Obstructive Pulmonary Disease, Early Disease, Physiology, Emphysema, Airflow Obstruction, Diseases of the respiratory system, RC705-779
Abstract

James A Stockley,1 Brendan G Cooper,1 Robert A Stockley,2 Elizabeth Sapey3 1Department of Lung Function and Sleep, 2Department of Respiratory Medicine, University Hospital Birmingham, 3Institute of Inflammation and Ageing, Centre for Translational Inflammation Research, University of Birmingham, Edgbaston, Birmingham, UK Abstract: It is increasingly acknowledged that delays in the diagnosis of chronic inflammatory lung conditions have hampered our understanding of pathogenesis and thus our ability to design efficacious therapies. This is particularly true for COPD, where most patients are diagnosed with moderate-to-severe airflow obstruction and little is known about the inflammatory processes present in early disease. There is great interest in developing screening tests that can identify those most at risk of developing COPD before airflow obstruction has developed for the purpose of research and clinical care. Landmark pathology studies have suggested that damage to the small airways precedes the development of airflow obstruction and emphysema and, thus, presents an opportunity to identify those at risk of COPD. However, despite a number of physiological tests being available to assess small airways function, none have been adopted into routine care in COPD. The reasons that tests of small airways have not been utilized widely include variability in test results and a lack of validated reference ranges from which to compare results for some methodologies. Furthermore, population studies have not consistently demonstrated their ability to diagnose disease. However, the landscape may be changing. As the equipment that delivers tests of small airways become more widely available, reference ranges are emerging and newer methodologies specifically seek to address variability and difficulty in test performance. Moreover, there is evidence that while tests of small airways may not be helpful across the full range of established disease severity, there may be specific groups (particularly those with early disease) where they might be informative. In this review, commonly utilized tests of small airways are critically appraised to highlight why these tests may be important, how they can be used and what knowledge gaps remain for their use in COPD. Keywords: small airways, COPD, early disease, physiology, emphysema, airflow obstruction

Published
2017

17. Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

Author

Hobbins S, Chapple ILC, Sapey E, and Stockley RA

Subjects
Inflammation, emphysema, dental health, smoking, neutrophil, Diseases of the respiratory system, RC705-779
Abstract

Stephanie Hobbins,1 Iain LC Chapple,2 Elizabeth Sapey,1,3 Robert A Stockley4 1Institute of Inflammation and Aging, 2School of Dentistry, University of Birmingham, Birmingham, 3Centre for Translational Inflammation Research, Institute of Inflammation and Aging, Queen Elizabeth Hospital, 4University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, UK Abstract: COPD is recognized as having a series of comorbidities potentially related to common inflammatory processes. Periodontitis is one of the most common human inflammatory diseases and has previously been associated with COPD in numerous observational studies. As periodontitis and COPD are both chronic, progressive conditions characterized by neutrophilic inflammation with subsequent proteolytic destruction of connective tissue, it has been proposed that they share common pathophysiological processes. The mechanisms proposed to link COPD and periodontitis include mechanical aspiration of oral contents into the respiratory tree, overspill of locally produced inflammatory mediators into systemic circulation or oral or lung-derived bacteremia activating an acute-phase response with subsequent reactive oxygen species (ROS) and cytokine release by systemic neutrophils at distant sites. Studies of systemic neutrophils in COPD and chronic periodontitis describe altered cellular functions that would predispose to inflammation and tissue destruction both in the lung and in the mouth, again potentially connecting these conditions. However, COPD and periodontitis also share risk factors such as age, chronic tobacco smoke exposure, and social deprivation that are not always considered in observational and interventional studies. Furthermore, studies reporting associations have often utilized differing definitions of both COPD and periodontitis. This article reviews the current available evidence supporting the hypothesis that COPD and inflammatory periodontal disease (periodontitis) could be pathologically associated, including a review of shared inflammatory mechanisms. It highlights the potential limitations of previous studies, in particular, the lack of uniformly applied case definitions for both COPD and periodontitis and poor recognition of shared risk factors. Understanding associations between these conditions may inform why patients with COPD suffer such a burden of comorbid illness and new therapeutic strategies for both the diseases. However, further research is needed to clarify factors that may be directly causal as opposed to confounding relationships. Keywords: inflammation, emphysema, dental health, smoking, neutrophil

Published
2017

18. Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review

Author

Edgar RG, Patel M, Bayliss S, Crossley D, Sapey E, and Turner AM

Subjects
Alpha-1 Antitrypsin Deficiency, Treatment, Emphysema, Transplantation, Diseases of the respiratory system, RC705-779
Abstract

Ross G Edgar,1,2 Mitesh Patel,3 Susan Bayliss,4 Diana Crossley,2,5 Elizabeth Sapey,2,5 Alice M Turner4,6 1Therapy Services, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; 2Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK; 3Division of Primary Care, University of Nottingham, Nottingham, UK; 4Institute of Applied Health Research, University of Birmingham, Birmingham, UK; 5Department of Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; 6Department of Respiratory Medicine, Heart of England NHS Foundation Trust, Birmingham, UK Background: Alpha-1 antitrypsin deficiency (AATD) is a rare genetic condition predisposing individuals to chronic obstructive pulmonary disease (COPD). The treatment is generally extrapolated from COPD unrelated to AATD; however, most COPD trials exclude AATD patients; thus, this study sought to systematically review AATD-specific literature to assist evidence-based patient management.Methods: Standard review methodology was used with meta-analysis and narrative synthesis (PROSPERO-CRD42015019354). Eligible studies were those of any treatment used in severe AATD. Randomized controlled trials (RCTs) were the primary focus; however, case series and uncontrolled studies were eligible. All studies had ≥10 participants receiving treatment or usual care, with baseline and follow-up data (>3 months). Risk of bias was assessed appropriately according to study methodology.Results: In all, 7,296 studies were retrieved from searches; 52 trials with 5,632 participants met the inclusion criteria, of which 26 studies involved alpha-1 antitrypsin augmentation and 17 concerned surgical treatments (largely transplantation). Studies were grouped into four management themes: COPD medical, COPD surgical, AATD specific, and other treatments. Computed tomography (CT) density, forced expiratory volume in 1 s, diffusing capacity of the lungs for carbon monoxide, health status, and exacerbation rates were frequently used as outcomes. Meta-analyses were only possible for RCTs of intravenous augmentation, which slowed progression of emphysema measured by CT density change, 0.79 g/L/year versus placebo (P=0.002), and associated with a small increase in exacerbations 0.29/year (P=0.02). Mortality following lung transplant was comparable between AATD- and non-AATD-related COPD. Surgical reduction of lung volume demonstrated inferior outcomes compared with non-AATD-related emphysema.Conclusion: Intravenous augmentation remains the only disease-specific therapy in AATD and there is evidence that this slows decline in emphysema determined by CT density. There is paucity of data around other treatments in AATD. Treatments for usual COPD may not be as efficacious in AATD, and further studies may be required for this disease group. Keywords: alpha-1 antitrypsin deficiency, treatment, emphysema, transplantation

Published
2017

19. Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

Author

McAuley, Hamish J.C., primary, Evans, Rachael A., additional, Bolton, Charlotte E., additional, Brightling, Christopher E., additional, Chalmers, James D., additional, Docherty, Annemarie B., additional, Elneima, Omer, additional, Greenhaff, Paul L., additional, Gupta, Ayushman, additional, Harris, Victoria C., additional, Harrison, Ewen M., additional, Ho, Ling-Pei, additional, Horsley, Alex, additional, Houchen-Wolloff, Linzy, additional, Jolley, Caroline J., additional, Leavy, Olivia C., additional, Lone, Nazir I., additional, Man, William D-C, additional, Marks, Michael, additional, Parekh, Dhruv, additional, Poinasamy, Krisnah, additional, Quint, Jennifer K., additional, Raman, Betty, additional, Richardson, Matthew, additional, Saunders, Ruth M., additional, Sereno, Marco, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Singh, Sally J., additional, Steiner, Michael, additional, Tan, Ai Lyn, additional, Wain, Louise V., additional, Welch, Carly, additional, Whitney, Julie, additional, Witham, Miles D., additional, Lord, Janet, additional, Greening, Neil J., additional, Abel, K., additional, Adamali, H., additional, Adeloye, D., additional, Adeyemi, O., additional, Adrego, R., additional, Aguilar Jimenez, L.A., additional, Ahmad, S., additional, Ahmad Haider, N., additional, Ahmed, R., additional, Ahwireng, N., additional, Ainsworth, M., additional, Al-Sheklly, B., additional, Alamoudi, A., additional, Ali, M., additional, Aljaroof, M., additional, All, A.M., additional, Allan, L., additional, Allen, R.J., additional, Allerton, L., additional, Allsop, L., additional, Almeida, P., additional, Altmann, D., additional, Alvarez Corral, M., additional, Amoils, S., additional, Anderson, D., additional, Antoniades, C., additional, Arbane, G., additional, Arias, A., additional, Armour, C., additional, Armstrong, L., additional, Armstrong, N., additional, Arnold, D., additional, Arnold, H., additional, Ashish, A., additional, Ashworth, A., additional, Ashworth, M., additional, Aslani, S., additional, Assefa-Kebede, H., additional, Atkin, C., additional, Atkin, P., additional, Aul, R., additional, Aung, H., additional, Austin, L., additional, Avram, C., additional, Ayoub, A., additional, Babores, M., additional, Baggott, R., additional, Bagshaw, J., additional, Baguley, D., additional, Bailey, L., additional, Baillie, J.K., additional, Bain, S., additional, Bakali, M., additional, Bakau, M., additional, Baldry, E., additional, Baldwin, D., additional, Baldwin, M., additional, Ballard, C., additional, Banerjee, A., additional, Bang, B., additional, Barker, R.E., additional, Barman, L., additional, Barratt, S., additional, Barrett, F., additional, Basire, D., additional, Basu, N., additional, Bates, M., additional, Bates, A., additional, Batterham, R., additional, Baxendale, H., additional, Bayes, H., additional, Beadsworth, M., additional, Beckett, P., additional, Beggs, M., additional, Begum, M., additional, Beirne, P., additional, Bell, D., additional, Bell, R., additional, Bennett, K., additional, Beranova, E., additional, Bermperi, A., additional, Berridge, A., additional, Berry, C., additional, Betts, S., additional, Bevan, E., additional, Bhui, K., additional, Bingham, M., additional, Birchall, K., additional, Bishop, L., additional, Bisnauthsing, K., additional, Blaikely, J., additional, Bloss, A., additional, Bolger, A., additional, Bolton, C.E., additional, Bonnington, J., additional, Botkai, A., additional, Bourne, C., additional, Bourne, M., additional, Bramham, K., additional, Brear, L., additional, Breen, G., additional, Breeze, J., additional, Briggs, A., additional, Bright, E., additional, Brightling, C.E., additional, Brill, S., additional, Brindle, K., additional, Broad, L., additional, Broadley, A., additional, Brookes, C., additional, Broome, M., additional, Brown, A., additional, Brown, J., additional, Brown, J.S., additional, Brown, M., additional, Brown, V., additional, Brugha, T., additional, Brunskill, N., additional, Buch, M., additional, Buckley, P., additional, Bularga, A., additional, Bullmore, E., additional, Burden, L., additional, Burdett, T., additional, Burn, D., additional, Burns, G., additional, Burns, A., additional, Busby, J., additional, Butcher, R., additional, Butt, A., additional, Byrne, S., additional, Cairns, P., additional, Calder, P.C., additional, Calvelo, E., additional, Carborn, H., additional, Card, B., additional, Carr, C., additional, Carr, L., additional, Carson, G., additional, Carter, P., additional, Casey, A., additional, Cassar, M., additional, Cavanagh, J., additional, Chablani, M., additional, Chalder, T., additional, Chalmers, J.D., additional, Chambers, R.C., additional, Chan, F., additional, Channon, K.M., additional, Chapman, K., additional, Charalambou, A., additional, Chaudhuri, N., additional, Checkley, A., additional, Chen, J., additional, Cheng, Y., additional, Chetham, L., additional, Childs, C., additional, Chilvers, E.R., additional, Chinoy, H., additional, Chiribiri, A., additional, Chong-James, K., additional, Choudhury, G., additional, Choudhury, N., additional, Chowienczyk, P., additional, Christie, C., additional, Chrystal, M., additional, Clark, D., additional, Clark, C., additional, Clarke, J., additional, Clohisey, S., additional, Coakley, G., additional, Coburn, Z., additional, Coetzee, S., additional, Cole, J., additional, Coleman, C., additional, Conneh, F., additional, Connell, D., additional, Connolly, B., additional, Connor, L., additional, Cook, A., additional, Cooper, B., additional, Cooper, J., additional, Cooper, S., additional, Copeland, D., additional, Cosier, T., additional, Coulding, M., additional, Coupland, C., additional, Cox, E., additional, Craig, T., additional, Crisp, P., additional, Cristiano, D., additional, Crooks, M.G., additional, Cross, A., additional, Cruz, I., additional, Cullinan, P., additional, Cuthbertson, D., additional, Daines, L., additional, Dalton, M., additional, Daly, P., additional, Daniels, A., additional, Dark, P., additional, Dasgin, J., additional, David, A., additional, David, C., additional, Davies, E., additional, Davies, F., additional, Davies, G., additional, Davies, G.A., additional, Davies, K., additional, Davies, M.J., additional, Dawson, J., additional, Daynes, E., additional, De Soyza, A., additional, Deakin, B., additional, Deans, A., additional, Deas, C., additional, Deery, J., additional, Defres, S., additional, Dell, A., additional, Dempsey, K., additional, Denneny, E., additional, Dennis, J., additional, Dewar, A., additional, Dharmagunawardena, R., additional, Diar-Bakerly, N., additional, Dickens, C., additional, Dipper, A., additional, Diver, S., additional, Diwanji, S.N., additional, Dixon, M., additional, Djukanovic, R., additional, Dobson, H., additional, Dobson, S.L., additional, Docherty, A.B., additional, Donaldson, A., additional, Dong, T., additional, Dormand, N., additional, Dougherty, A., additional, Dowling, R., additional, Drain, S., additional, Draxlbauer, K., additional, Drury, K., additional, Drury, H.J.C., additional, Dulawan, P., additional, Dunleavy, A., additional, Dunn, S., additional, Dupont, C., additional, Earley, J., additional, Easom, N., additional, Echevarria, C., additional, Edwards, S., additional, Edwardson, C., additional, El-Taweel, H., additional, Elliott, A., additional, Elliott, K., additional, Ellis, Y., additional, Elmer, A., additional, Elneima, O., additional, Evans, D., additional, Evans, H., additional, Evans, J., additional, Evans, R., additional, Evans, R.A., additional, Evans, R.I., additional, Evans, T., additional, Evenden, C., additional, Evison, L., additional, Fabbri, L., additional, Fairbairn, S., additional, Fairman, A., additional, Fallon, K., additional, Faluyi, D., additional, Favager, C., additional, Fayzan, T., additional, Featherstone, J., additional, Felton, T., additional, Finch, J., additional, Finney, S., additional, Finnigan, J., additional, Finnigan, L., additional, Fisher, H., additional, Fletcher, S., additional, Flockton, R., additional, Flynn, M., additional, Foot, H., additional, Foote, D., additional, Ford, A., additional, Forton, D., additional, Fraile, E., additional, Francis, C., additional, Francis, R., additional, Francis, S., additional, Frankel, A., additional, Fraser, E., additional, Free, R., additional, French, N., additional, Fu, X., additional, Fuld, J., additional, Furniss, J., additional, Garner, L., additional, Gautam, N., additional, Geddes, J.R., additional, George, J., additional, George, P., additional, Gibbons, M., additional, Gill, M., additional, Gilmour, L., additional, Gleeson, F., additional, Glossop, J., additional, Glover, S., additional, Goodman, N., additional, Goodwin, C., additional, Gooptu, B., additional, Gordon, H., additional, Gorsuch, T., additional, Greatorex, M., additional, Greenhaff, P.L., additional, Greenhalf, W., additional, Greenhalgh, A., additional, Greening, N.J., additional, Greenwood, J., additional, Gregory, H., additional, Gregory, R., additional, Grieve, D., additional, Griffin, D., additional, Griffiths, L., additional, Guerdette, A.-M., additional, Guillen Guio, B., additional, Gummadi, M., additional, Gupta, A., additional, Gurram, S., additional, Guthrie, E., additional, Guy, Z., additional, Henson, H.H., additional, Hadley, K., additional, Haggar, A., additional, Hainey, K., additional, Hairsine, B., additional, Haldar, P., additional, Hall, I., additional, Hall, L., additional, Halling-Brown, M., additional, Hamil, R., additional, Hancock, A., additional, Hancock, K., additional, Hanley, N.A., additional, Haq, S., additional, Hardwick, H.E., additional, Hardy, E., additional, Hardy, T., additional, Hargadon, B., additional, Harrington, K., additional, Harris, E., additional, Harris, V.C., additional, Harrison, E.M., additional, Harrison, P., additional, Hart, N., additional, Harvey, A., additional, Harvey, M., additional, Harvie, M., additional, Haslam, L., additional, Havinden-Williams, M., additional, Hawkes, J., additional, Hawkings, N., additional, Haworth, J., additional, Hayday, A., additional, Haynes, M., additional, Hazeldine, J., additional, Hazelton, T., additional, Heaney, L.G., additional, Heeley, C., additional, Heeney, J.L., additional, Heightman, M., additional, Heller, S., additional, Henderson, M., additional, Hesselden, L., additional, Hewitt, M., additional, Highett, V., additional, Hillman, T., additional, Hiwot, T., additional, Ho, L.P., additional, Hoare, A., additional, Hoare, M., additional, Hockridge, J., additional, Hogarth, P., additional, Holbourn, A., additional, Holden, S., additional, Holdsworth, L., additional, Holgate, D., additional, Holland, M., additional, Holloway, L., additional, Holmes, K., additional, Holmes, M., additional, Holroyd-Hind, B., additional, Holt, L., additional, Hormis, A., additional, Horsley, A., additional, Hosseini, A., additional, Hotopf, M., additional, Houchen-Wolloff, L., additional, Howard, K., additional, Howard, L.S., additional, Howell, A., additional, Hufton, E., additional, Hughes, A.D., additional, Hughes, J., additional, Hughes, R., additional, Humphries, A., additional, Huneke, N., additional, Hurditch, E., additional, Hurst, J., additional, Husain, M., additional, Hussell, T., additional, Hutchinson, J., additional, Ibrahim, W., additional, Ilyas, F., additional, Ingham, J., additional, Ingram, L., additional, Ionita, D., additional, Isaacs, K., additional, Ismail, K., additional, Jackson, T., additional, Jacob, J., additional, James, W.Y., additional, Jang, W., additional, Jarman, C., additional, Jarrold, I., additional, Jarvis, H., additional, Jastrub, R., additional, Jayaraman, B., additional, Jenkins, R.G., additional, Jezzard, P., additional, Jiwa, K., additional, Johnson, C., additional, Johnson, S., additional, Johnston, D., additional, Jolley, C.J., additional, Jones, D., additional, Jones, G., additional, Jones, H., additional, Jones, I., additional, Jones, L., additional, Jones, M.G., additional, Jones, S., additional, Jose, S., additional, Kabir, T., additional, Kaltsakas, G., additional, Kamwa, V., additional, Kanellakis, N., additional, Kaprowska, S., additional, Kausar, Z., additional, Keenan, N., additional, Kelly, S., additional, Kemp, G., additional, Kerr, S., additional, Kerslake, H., additional, Key, A.L., additional, Khan, F., additional, Khunti, K., additional, Kilroy, S., additional, King, B., additional, King, C., additional, Kingham, L., additional, Kirk, J., additional, Kitterick, P., additional, Klenerman, P., additional, Knibbs, L., additional, Knight, S., additional, Knighton, A., additional, Kon, O., additional, Kon, S., additional, Kon, S.S., additional, Koprowska, S., additional, Korszun, A., additional, Koychev, I., additional, Kurasz, C., additional, Kurupati, P., additional, Laing, C., additional, Lamlum, H., additional, Landers, G., additional, Langenberg, C., additional, Lasserson, D., additional, Lavelle-Langham, L., additional, Lawrie, A., additional, Lawson, C., additional, Layton, A., additional, Lea, A., additional, Leavy, O.C., additional, Lee, D., additional, Lee, J.-H., additional, Lee, E., additional, Leitch, K., additional, Lenagh, R., additional, Lewis, D., additional, Lewis, J., additional, Lewis, K.E., additional, Lewis, V., additional, Lewis-Burke, N., additional, Li, X., additional, Light, T., additional, Lightstone, L., additional, Lilaonitkul, W., additional, Lim, L., additional, Linford, S., additional, Lingford-Hughes, A., additional, Lipman, M., additional, Liyanage, K., additional, Lloyd, A., additional, Logan, S., additional, Lomas, D., additional, Lone, N.I., additional, Loosley, R., additional, Lord, J.M., additional, Lota, H., additional, Lovegrove, W., additional, Lucey, A., additional, Lukaschuk, E., additional, Lye, A., additional, Lynch, C., additional, MacDonald, S., additional, MacGowan, G., additional, Macharia, I., additional, Mackie, J., additional, Macliver, L., additional, Madathil, S., additional, Madzamba, G., additional, Magee, N., additional, Magtoto, M.M., additional, Mairs, N., additional, Majeed, N., additional, Major, E., additional, Malein, F., additional, Malim, M., additional, Mallison, G., additional, D-C Man, W., additional, Mandal, S., additional, Mangion, K., additional, Manisty, C., additional, Manley, R., additional, March, K., additional, Marciniak, S., additional, Marino, P., additional, Mariveles, M., additional, Marks, M., additional, Marouzet, E., additional, Marsh, S., additional, Marshall, B., additional, Marshall, M., additional, Martin, J., additional, Martineau, A., additional, Martinez, L.M., additional, Maskell, N., additional, Matila, D., additional, Matimba-Mupaya, W., additional, Matthews, L., additional, Mbuyisa, A., additional, McAdoo, S., additional, McAllister-Williams, H., additional, McArdle, A., additional, McArdle, P., additional, McAulay, D., additional, McCann, G.P., additional, McCormick, J., additional, McCormick, W., additional, McCourt, P., additional, McGarvey, L., additional, McGee, C., additional, Mcgee, K., additional, McGinness, J., additional, McGlynn, K., additional, McGovern, A., additional, McGuinness, H., additional, McInnes, I.B., additional, McIntosh, J., additional, McIvor, E., additional, McIvor, K., additional, McLeavey, L., additional, McMahon, A., additional, McMahon, M.J., additional, McMorrow, L., additional, Mcnally, T., additional, McNarry, M., additional, McNeill, J., additional, McQueen, A., additional, McShane, H., additional, Mears, C., additional, Megson, C., additional, Megson, S., additional, Mehta, P., additional, Meiring, J., additional, Melling, L., additional, Mencias, M., additional, Menzies, D., additional, Merida Morillas, M., additional, Michael, A., additional, Miller, C., additional, Milligan, L., additional, Mills, C., additional, Mills, G., additional, Mills, N.L., additional, Milner, L., additional, Misra, S., additional, Mitchell, J., additional, Mohamed, A., additional, Mohamed, N., additional, Mohammed, S., additional, Molyneaux, P.L., additional, Monteiro, W., additional, Moriera, S., additional, Morley, A., additional, Morrison, L., additional, Morriss, R., additional, Morrow, A., additional, Moss, A.J., additional, Moss, P., additional, Motohashi, K., additional, Msimanga, N., additional, Mukaetova-Ladinska, E., additional, Munawar, U., additional, Murira, J., additional, Nanda, U., additional, Nassa, H., additional, Nasseri, M., additional, Neal, A., additional, Needham, R., additional, Neill, P., additional, Neubauer, S., additional, Newby, D.E., additional, Newell, H., additional, Newman, T., additional, Newman, J., additional, Newton-Cox, A., additional, Nicholson, T., additional, Nicoll, D., additional, Nikolaidis, A., additional, Nolan, C.M., additional, Noonan, M.J., additional, Norman, C., additional, Novotny, P., additional, Nunag, J., additional, Nwafor, L., additional, Nwanguma, U., additional, Nyaboko, J., additional, O'Brien, C., additional, O'Donnell, K., additional, O'Regan, D., additional, O’Brien, L., additional, Odell, N., additional, Ogg, G., additional, Olaosebikan, O., additional, Oliver, C., additional, Omar, Z., additional, Openshaw, P.J.M., additional, Orriss-Dib, L., additional, Osborne, L., additional, Osbourne, R., additional, Ostermann, M., additional, Overton, C., additional, Owen, J., additional, Oxton, J., additional, Pack, J., additional, Pacpaco, E., additional, Paddick, S., additional, Painter, S., additional, Pakzad, A., additional, Palmer, S., additional, Papineni, P., additional, Paques, K., additional, Paradowski, K., additional, Pareek, M., additional, Parekh, D., additional, Parfrey, H., additional, Pariante, C., additional, Parker, S., additional, Parkes, M., additional, Parmar, J., additional, Patale, S., additional, Patel, B., additional, Patel, M., additional, Patel, S., additional, Pattenadk, D., additional, Pavlides, M., additional, Payne, S., additional, Pearce, L., additional, Pearl, J.E., additional, Peckham, D., additional, Pendlebury, J., additional, Peng, Y., additional, Pennington, C., additional, Peralta, I., additional, Perkins, E., additional, Peterkin, Z., additional, Peto, T., additional, Petousi, N., additional, Petrie, J., additional, Pfeffer, P., additional, Phipps, J., additional, Pimm, J., additional, Piper Hanley, K., additional, Pius, R., additional, Plant, H., additional, Plein, S., additional, Plekhanova, T., additional, Plowright, M., additional, Poinasamy, K., additional, Polgar, O., additional, Poll, L., additional, Porter, J.C., additional, Porter, J., additional, Portukhay, S., additional, Powell, N., additional, Prabhu, A., additional, Pratt, J., additional, Price, A., additional, Price, C., additional, Price, D., additional, Price, L., additional, Prickett, A., additional, Propescu, J., additional, Prosper, S., additional, Pugmire, S., additional, Quaid, S., additional, Quigley, J., additional, Quint, J., additional, Qureshi, H., additional, Qureshi, I.N., additional, Radhakrishnan, K., additional, Rahman, N.M., additional, Ralser, M., additional, Raman, B., additional, Ramos, A., additional, Ramos, H., additional, Rangeley, J., additional, Rangelov, B., additional, Ratcliffe, L., additional, Ravencroft, P., additional, Reddington, A., additional, Reddy, R., additional, Reddy, A., additional, Redfearn, H., additional, Redwood, D., additional, Reed, A., additional, Rees, M., additional, Rees, T., additional, Regan, K., additional, Reynolds, W., additional, Ribeiro, C., additional, Richards, A., additional, Richardson, E., additional, Richardson, M., additional, Rivera-Ortega, P., additional, Roberts, K., additional, Robertson, E., additional, Robinson, E., additional, Robinson, L., additional, Roche, L., additional, Roddis, C., additional, Rodger, J., additional, Ross, A., additional, Ross, G., additional, Rossdale, J., additional, Rostron, A., additional, Rowe, A., additional, Rowland, A., additional, Rowland, J., additional, Rowland, M.J., additional, Rowland-Jones, S.L., additional, Roy, K., additional, Roy, M., additional, Rudan, I., additional, Russell, R., additional, Russell, E., additional, Saalmink, G., additional, Sabit, R., additional, Sage, E.K., additional, Samakomva, T., additional, Samani, N., additional, Sampson, C., additional, Samuel, K., additional, Samuel, R., additional, Sanderson, A., additional, Sapey, E., additional, Saralaya, D., additional, Sargant, J., additional, Sarginson, C., additional, Sass, T., additional, Sattar, N., additional, Saunders, K., additional, Saunders, R.M., additional, Saunders, P., additional, Saunders, L.C., additional, Savill, H., additional, Saxon, W., additional, Sayer, A., additional, Schronce, J., additional, Schwaeble, W., additional, Scott, J.T., additional, Scott, K., additional, Selby, N., additional, Semple, M.G., additional, Sereno, M., additional, Sewell, T.A., additional, Shah, A., additional, Shah, K., additional, Shah, P., additional, Shankar-Hari, M., additional, Sharma, M., additional, Sharpe, C., additional, Sharpe, M., additional, Shashaa, S., additional, Shaw, A., additional, Shaw, K., additional, Shaw, V., additional, Sheikh, A., additional, Shelton, S., additional, Shenton, L., additional, Shevket, K., additional, Shikotra, A., additional, Short, J., additional, Siddique, S., additional, Siddiqui, S., additional, Sidebottom, J., additional, Sigfrid, L., additional, Simons, G., additional, Simpson, J., additional, Simpson, N., additional, Singapuri, A., additional, Singh, C., additional, Singh, S., additional, Singh, S.J., additional, Sissons, D., additional, Skeemer, J., additional, Slack, K., additional, Smith, A., additional, Smith, D., additional, Smith, S., additional, Smith, J., additional, Smith, L., additional, Soares, M., additional, Solano, T.S., additional, Solly, R., additional, Solstice, A.R., additional, Soulsby, T., additional, Southern, D., additional, Sowter, D., additional, Spears, M., additional, Spencer, L.G., additional, Speranza, F., additional, Stadon, L., additional, Stanel, S., additional, Steele, N., additional, Steiner, M., additional, Stensel, D., additional, Stephens, G., additional, Stephenson, L., additional, Stern, M., additional, Stewart, I., additional, Stimpson, R., additional, Stockdale, S., additional, Stockley, J., additional, Stoker, W., additional, Stone, R., additional, Storrar, W., additional, Storrie, A., additional, Storton, K., additional, Stringer, E., additional, Strong-Sheldrake, S., additional, Stroud, N., additional, Subbe, C., additional, Sudlow, C.L., additional, Suleiman, Z., additional, Summers, C., additional, Summersgill, C., additional, Sutherland, D., additional, Sykes, D.L., additional, Sykes, R., additional, Talbot, N., additional, Tan, A.L., additional, Tarusan, L., additional, Tavoukjian, V., additional, Taylor, A., additional, Taylor, C., additional, Taylor, J., additional, Te, A., additional, Tedd, H., additional, Tee, C.J., additional, Teixeira, J., additional, Tench, H., additional, Terry, S., additional, Thackray-Nocera, S., additional, Thaivalappil, F., additional, Thamu, B., additional, Thickett, D., additional, Thomas, C., additional, Thomas, D.C., additional, Thomas, S., additional, Thomas, A.K., additional, Thomas-Woods, T., additional, Thompson, T., additional, Thompson, A.A.R., additional, Thornton, T., additional, Thorpe, M., additional, Thwaites, R.S., additional, Tilley, J., additional, Tinker, N., additional, Tiongson, G.F., additional, Tobin, M., additional, Tomlinson, J., additional, Tong, C., additional, Toshner, M., additional, Touyz, R., additional, Tripp, K.A., additional, Tunnicliffe, E., additional, Turnbull, A., additional, Turner, E., additional, Turner, S., additional, Turner, V., additional, Turner, K., additional, Turney, S., additional, Turtle, L., additional, Turton, H., additional, Ugoji, J., additional, Ugwuoke, R., additional, Upthegrove, R., additional, Valabhji, J., additional, Ventura, M., additional, Vere, J., additional, Vickers, C., additional, Vinson, B., additional, Wade, E., additional, Wade, P., additional, Wain, L.V., additional, Wainwright, T., additional, Wajero, L.O., additional, Walder, S., additional, Walker, S., additional, Wall, E., additional, Wallis, T., additional, Walmsley, S., additional, Walsh, J.A., additional, Walsh, S., additional, Warburton, L., additional, Ward, T.J.C., additional, Warwick, K., additional, Wassall, H., additional, Waterson, S., additional, Watson, E., additional, Watson, L., additional, Watson, J., additional, Weir McCall, J., additional, Welch, C., additional, Welch, H., additional, Welsh, B., additional, Wessely, S., additional, West, S., additional, Weston, H., additional, Wheeler, H., additional, White, S., additional, Whitehead, V., additional, Whitney, J., additional, Whittaker, S., additional, Whittam, B., additional, Whitworth, V., additional, Wight, A., additional, Wild, J., additional, Wilkins, M., additional, Wilkinson, D., additional, Williams, B., additional, Williams, N., additional, Williams, J., additional, Williams-Howard, S.A., additional, Willicombe, M., additional, Willis, G., additional, Willoughby, J., additional, Wilson, A., additional, Wilson, D., additional, Wilson, I., additional, Window, N., additional, Witham, M., additional, Wolf-Roberts, R., additional, Wood, C., additional, Woodhead, F., additional, Woods, J., additional, Wootton, D.G., additional, Wormleighton, J., additional, Worsley, J., additional, Wraith, D., additional, Wrey Brown, C., additional, Wright, C., additional, Wright, L., additional, Wright, S., additional, Wyles, J., additional, Wynter, I., additional, Xu, M., additional, Yasmin, N., additional, Yasmin, S., additional, Yates, T., additional, Yip, K.P., additional, Young, B., additional, Young, S., additional, Young, A., additional, Yousuf, A.J., additional, Zawia, A., additional, Zeidan, L., additional, Zhao, B., additional, Zheng, B., additional, and Zongo, O., additional

Published
2023
Full Text
View/download PDF

20. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Author

Liew, Felicity, primary, Talwar, Shubha, additional, Cross, Andy, additional, Willett, Brian J., additional, Scott, Sam, additional, Logan, Nicola, additional, Siggins, Matthew K., additional, Swieboda, Dawid, additional, Sidhu, Jasmin K., additional, Efstathiou, Claudia, additional, Moore, Shona C., additional, Davis, Chris, additional, Mohamed, Noura, additional, Nunag, Jose, additional, King, Clara, additional, Thompson, A.A. Roger, additional, Rowland-Jones, Sarah L., additional, Docherty, Annemarie B., additional, Chalmers, James D., additional, Ho, Ling-Pei, additional, Horsley, Alexander, additional, Raman, Betty, additional, Poinasamy, Krisnah, additional, Marks, Michael, additional, Kon, Onn Min, additional, Howard, Luke, additional, Wootton, Daniel G., additional, Dunachie, Susanna, additional, Quint, Jennifer K., additional, Evans, Rachael A., additional, Wain, Louise V., additional, Fontanella, Sara, additional, de Silva, Thushan I., additional, Ho, Antonia, additional, Harrison, Ewen, additional, Baillie, J. Kenneth, additional, Semple, Malcolm G., additional, Brightling, Christopher, additional, Thwaites, Ryan S., additional, Turtle, Lance, additional, Openshaw, Peter J.M., additional, Alex, Beatrice, additional, Andrikopoulos, Petros, additional, Bach, Benjamin, additional, Barclay, Wendy S., additional, Bogaert, Debby, additional, Chand, Meera, additional, Chechi, Kanta, additional, Cooke, Graham S., additional, da Silva Filipe, Ana, additional, de Silva, Thushan, additional, dos Santos Correia, Gonçalo, additional, Dumas, Marc-Emmanuel, additional, Dunning, Jake, additional, Fletcher, Tom, additional, Green, Christopher A., additional, Greenhalf, William, additional, Griffin, Julian, additional, Gupta, Rishi K., additional, Harrison, Ewen M., additional, Ho, Antonia Y.W., additional, Holden, Karl, additional, Horby, Peter W., additional, Ijaz, Samreen, additional, Khoo, Say, additional, Klenerman, Paul, additional, Law, Andrew, additional, Lewis, Matthew, additional, Liggi, Sonia, additional, Lim, Wei Shen, additional, Maslen, Lynn, additional, Mentzer, Alexander J., additional, Merson, Laura, additional, Meynert, Alison M, additional, Noursadeghi, Mahdad, additional, Olanipekun, Michael, additional, Osagie, Anthonia, additional, Palmarini, Massimo, additional, Palmieri, Carlo, additional, Paxton, William A., additional, Pollakis, Georgios, additional, Price, Nicholas, additional, Rambaut, Andrew, additional, Robertson, David L, additional, Russell, Clark D., additional, Sancho-Shimizu, Vanessa, additional, Sands, Caroline, additional, Scott, Janet T., additional, Sigfrid, Louise, additional, Solomon, Tom, additional, Sriskandan, Shiranee, additional, Stuart, David, additional, Summers, Charlotte, additional, Swann, Olivia V., additional, Takats, Zoltan, additional, Takis, Panteleimon, additional, Tedder, Richard S., additional, Thomson, Emma C., additional, Turtle, Lance C.W., additional, Zambon, Maria, additional, Drake, Thomas M., additional, Fairfield, Cameron J., additional, Knight, Stephen R., additional, Mclean, Kenneth A., additional, Murphy, Derek, additional, Norman, Lisa, additional, Pius, Riinu, additional, Shaw, Catherine A., additional, Connor, Marie, additional, Dalton, Jo, additional, Gamble, Carrol, additional, Girvan, Michelle, additional, Halpin, Sophie, additional, Harrison, Janet, additional, Jackson, Clare, additional, Lee, James, additional, Marsh, Laura, additional, Plotkin, Daniel, additional, Roberts, Stephanie, additional, Saviciute, Egle, additional, Clohisey, Sara, additional, Hendry, Ross, additional, Knight, Susan, additional, Lahnsteiner, Eva, additional, Leeming, Gary, additional, Norris, Lucy, additional, Scott-Brown, James, additional, Tait, Sarah, additional, Wham, Murray, additional, Clark, Richard, additional, Coutts, Audrey, additional, Donelly, Lorna, additional, Fawkes, Angie, additional, Gilchrist, Tammy, additional, Hafezi, Katarzyna, additional, MacGillivray, Louise, additional, Maclean, Alan, additional, McCafferty, Sarah, additional, Morrice, Kirstie, additional, Murphy, Lee, additional, Wrobel, Nicola, additional, Carson, Gail, additional, Adeniji, Kayode, additional, Agranoff, Daniel, additional, Agwuh, Ken, additional, Ail, Dhiraj, additional, Aldera, Erin L., additional, Alegria, Ana, additional, Allen, Sam, additional, Angus, Brian, additional, Ashish, Abdul, additional, Atkinson, Dougal, additional, Bari, Shahedal, additional, Barlow, Gavin, additional, Barnass, Stella, additional, Barrett, Nicholas, additional, Bassford, Christopher, additional, Basude, Sneha, additional, Baxter, David, additional, Beadsworth, Michael, additional, Bernatoniene, Jolanta, additional, Berridge, John, additional, Berry, Colin, additional, Best, Nicola, additional, Bothma, Pieter, additional, Brittain-Long, Robin, additional, Bulteel, Naomi, additional, Burden, Tom, additional, Burtenshaw, Andrew, additional, Caruth, Vikki, additional, Chadwick, David, additional, Chambler, Duncan, additional, Chee, Nigel, additional, Child, Jenny, additional, Chukkambotla, Srikanth, additional, Clark, Tom, additional, Collini, Paul, additional, Cosgrove, Catherine, additional, Cupitt, Jason, additional, Cutino-Moguel, Maria-Teresa, additional, Dark, Paul, additional, Dawson, Chris, additional, Dervisevic, Samir, additional, Donnison, Phil, additional, Douthwaite, Sam, additional, Drummond, Andrew, additional, DuRand, Ingrid, additional, Dushianthan, Ahilanadan, additional, Dyer, Tristan, additional, Evans, Cariad, additional, Eziefula, Chi, additional, Fegan, Chrisopher, additional, Finn, Adam, additional, Fullerton, Duncan, additional, Garg, Sanjeev, additional, Garg, Atul, additional, Gkrania-Klotsas, Effrossyni, additional, Godden, Jo, additional, Goldsmith, Arthur, additional, Graham, Clive, additional, Grammatikopoulos, Tassos, additional, Hardy, Elaine, additional, Hartshorn, Stuart, additional, Harvey, Daniel, additional, Havalda, Peter, additional, Hawcutt, Daniel B., additional, Hobrok, Maria, additional, Hodgson, Luke, additional, Hormis, Anil, additional, Howard, Joanne, additional, Jacobs, Michael, additional, Jain, Susan, additional, Jennings, Paul, additional, Kaliappan, Agilan, additional, Kasipandian, Vidya, additional, Kegg, Stephen, additional, Kelsey, Michael, additional, Kendall, Jason, additional, Kerrison, Caroline, additional, Kerslake, Ian, additional, Koch, Oliver, additional, Koduri, Gouri, additional, Koshy, George, additional, Laha, Shondipon, additional, Laird, Steven, additional, Larkin, Susan, additional, Leiner, Tamas, additional, Lillie, Patrick, additional, Limb, James, additional, Linnett, Vanessa, additional, Little, Jeff, additional, Lyttle, Mark, additional, MacMahon, Michael, additional, MacNaughton, Emily, additional, Mankregod, Ravish, additional, Masson, Huw, additional, Matovu, Elijah, additional, McCullough, Katherine, additional, McEwen, Ruth, additional, Meda, Manjula, additional, Mills, Gary, additional, Minton, Jane, additional, Mohandas, Kavya, additional, Mok, Quen, additional, Moon, James, additional, Moore, Elinoor, additional, Morgan, Patrick, additional, Morris, Craig, additional, Mortimore, Katherine, additional, Moses, Samuel, additional, Mpenge, Mbiye, additional, Mulla, Rohinton, additional, Murphy, Michael, additional, Nagarajan, Thapas, additional, Nagel, Megan, additional, Nelson, Mark, additional, Norris, Lillian, additional, O'Shea, Matthew K., additional, Ostermann, Marlies, additional, Otahal, Igor, additional, Pais, Mark, additional, Panchatsharam, Selva, additional, Papakonstantinou, Danai, additional, Papineni, Padmasayee, additional, Paraiso, Hassan, additional, Patel, Brij, additional, Pattison, Natalie, additional, Pepperell, Justin, additional, Peters, Mark, additional, Phull, Mandeep, additional, Pintus, Stefania, additional, Planche, Tim, additional, Post, Frank, additional, Price, David, additional, Prout, Rachel, additional, Rae, Nikolas, additional, Reschreiter, Henrik, additional, Reynolds, Tim, additional, Richardson, Neil, additional, Roberts, Mark, additional, Roberts, Devender, additional, Rose, Alistair, additional, Rousseau, Guy, additional, Ruge, Bobby, additional, Ryan, Brendan, additional, Saluja, Taranprit, additional, Sarah, Sarah, additional, Schmid, Matthias, additional, Shah, Aarti, additional, Shankar-Hari, Manu, additional, Shanmuga, Prad, additional, Sharma, Anil, additional, Shawcross, Anna, additional, Singh Pooni, Jagtur, additional, Sizer, Jeremy, additional, Smith, Richard, additional, Snelson, Catherine, additional, Spittle, Nick, additional, Staines, Nikki, additional, Stambach, Tom, additional, Stewart, Richard, additional, Subudhi, Pradeep, additional, Szakmany, Tamas, additional, Tatham, Kate, additional, Thomas, Jo, additional, Thompson, Chris, additional, Thompson, Robert, additional, Tridente, Ascanio, additional, Tupper-Carey, Darell, additional, Twagira, Mary, additional, Vallotton, Nick, additional, Vancheeswaran, Rama, additional, Vincent, Rachel, additional, Vincent-Smith, Lisa, additional, Visuvanathan, Shico, additional, Vuylsteke, Alan, additional, Waddy, Sam, additional, Wake, Rachel, additional, Walden, Andrew, additional, Welters, Ingeborg, additional, Whitehouse, Tony, additional, Whittaker, Paul, additional, Whittington, Ashley, additional, Wijesinghe, Meme, additional, Williams, Martin, additional, Wilson, Lawrence, additional, Winchester, Stephen, additional, Wiselka, Martin, additional, Wolverson, Adam, additional, Wootton, Daniel G, additional, Workman, Andrew, additional, Yates, Bryan, additional, Young, Peter, additional, McDonald, Sarah E., additional, Shaw, Victoria, additional, Ahmed, Katie A., additional, Armstrong, Jane A., additional, Ashworth, Milton, additional, Asiimwe, Innocent G., additional, Bakshi, Siddharth, additional, Barlow, Samantha L, additional, Booth, Laura, additional, Brennan, Benjamin, additional, Bullock, Katie, additional, Carlucci, Nicola, additional, Cass, Emily, additional, Catterall, Benjamin W.A., additional, Clark, Jordan J., additional, Clarke, Emily A., additional, Cole, Sarah, additional, Cooper, Louise, additional, Cox, Helen, additional, Davis, Christopher, additional, Dincarslan, Oslem, additional, Doce Carracedo, Alejandra, additional, Dunn, Chris, additional, Dyer, Philip, additional, Elliott, Angela, additional, Evans, Anthony, additional, Finch, Lorna, additional, Fisher, Lewis W.S., additional, Flaherty, Lisa, additional, Foster, Terry, additional, Garcia-Dorival, Isabel, additional, Gunning, Philip, additional, Hartley, Catherine, additional, Holmes, Anthony, additional, Jensen, Rebecca L., additional, Jones, Christopher B., additional, Jones, Trevor R., additional, Khandaker, Shadia, additional, King, Katharine, additional, Kiy, Robyn T., additional, Koukorava, Chrysa, additional, Lake, Annette, additional, Lant, Suzannah, additional, Latawiec, Diane, additional, Lavelle-Langham, Lara, additional, Lefteri, Daniella, additional, Lett, Lauren, additional, Livoti, Lucia A, additional, Mancini, Maria, additional, Massey, Hannah, additional, Maziere, Nicole, additional, McDonald, Sarah, additional, McEvoy, Laurence, additional, McLauchlan, John, additional, Metelmann, Soeren, additional, Miah, Nahida S., additional, Middleton, Joanna, additional, Mitchell, Joyce, additional, Murphy, Ellen G, additional, Penrice-Randal, Rebekah, additional, Pilgrim, Jack, additional, Prince, Tessa, additional, Reynolds, Will, additional, Ridley, P. Matthew, additional, Sales, Debby, additional, Shaw, Victoria E., additional, Shears, Rebecca K., additional, Small, Benjamin, additional, Subramaniam, Krishanthi S., additional, Szemiel, Agnieska, additional, Taggart, Aislynn, additional, Tanianis-Hughes, Jolanta, additional, Thomas, Jordan, additional, Trochu, Erwan, additional, van Tonder, Libby, additional, Wilcock, Eve, additional, Zhang, J. Eunice, additional, Keating, Seán, additional, Donegan, Cara, additional, Spencer, Rebecca G., additional, Donohue, Chloe, additional, Griffiths, Fiona, additional, Hardwick, Hayley, additional, Oosthuyzen, Wilna, additional, Abel, K., additional, Adamali, H., additional, Adeloye, D., additional, Adeyemi, O., additional, Adrego, R., additional, Aguilar Jimenez, L.A., additional, Ahmad, S., additional, Ahmad Haider, N., additional, Ahmed, R., additional, Ahwireng, N., additional, Ainsworth, M., additional, Al-Sheklly, B., additional, Alamoudi, A., additional, Ali, M., additional, Aljaroof, M., additional, All, A.M., additional, Allan, L., additional, Allen, R.J., additional, Allerton, L., additional, Allsop, L., additional, Almeida, P., additional, Altmann, D., additional, Alvarez Corral, M., additional, Amoils, S., additional, Anderson, D., additional, Antoniades, C., additional, Arbane, G., additional, Arias, A., additional, Armour, C., additional, Armstrong, L., additional, Armstrong, N., additional, Arnold, D., additional, Arnold, H., additional, Ashish, A., additional, Ashworth, A., additional, Ashworth, M., additional, Aslani, S., additional, Assefa-Kebede, H., additional, Atkin, C., additional, Atkin, P., additional, Aul, R., additional, Aung, H., additional, Austin, L., additional, Avram, C., additional, Ayoub, A., additional, Babores, M., additional, Baggott, R., additional, Bagshaw, J., additional, Baguley, D., additional, Bailey, L., additional, Baillie, J.K., additional, Bain, S., additional, Bakali, M., additional, Bakau, M., additional, Baldry, E., additional, Baldwin, D., additional, Baldwin, M., additional, Ballard, C., additional, Banerjee, A., additional, Bang, B., additional, Barker, R.E., additional, Barman, L., additional, Barratt, S., additional, Barrett, F., additional, Basire, D., additional, Basu, N., additional, Bates, M., additional, Bates, A., additional, Batterham, R., additional, Baxendale, H., additional, Bayes, H., additional, Beadsworth, M., additional, Beckett, P., additional, Beggs, M., additional, Begum, M., additional, Beirne, P., additional, Bell, D., additional, Bell, R., additional, Bennett, K., additional, Beranova, E., additional, Bermperi, A., additional, Berridge, A., additional, Berry, C., additional, Betts, S., additional, Bevan, E., additional, Bhui, K., additional, Bingham, M., additional, Birchall, K., additional, Bishop, L., additional, Bisnauthsing, K., additional, Blaikely, J., additional, Bloss, A., additional, Bolger, A., additional, Bolton, C.E., additional, Bonnington, J., additional, Botkai, A., additional, Bourne, C., additional, Bourne, M., additional, Bramham, K., additional, Brear, L., additional, Breen, G., additional, Breeze, J., additional, Briggs, A., additional, Bright, E., additional, Brightling, C.E., additional, Brill, S., additional, Brindle, K., additional, Broad, L., additional, Broadley, A., additional, Brookes, C., additional, Broome, M., additional, Brown, A., additional, Brown, J., additional, Brown, J.S., additional, Brown, M., additional, Brown, V., additional, Brugha, T., additional, Brunskill, N., additional, Buch, M., additional, Buckley, P., additional, Bularga, A., additional, Bullmore, E., additional, Burden, L., additional, Burdett, T., additional, Burn, D., additional, Burns, G., additional, Burns, A., additional, Busby, J., additional, Butcher, R., additional, Butt, A., additional, Byrne, S., additional, Cairns, P., additional, Calder, P.C., additional, Calvelo, E., additional, Carborn, H., additional, Card, B., additional, Carr, C., additional, Carr, L., additional, Carson, G., additional, Carter, P., additional, Casey, A., additional, Cassar, M., additional, Cavanagh, J., additional, Chablani, M., additional, Chalder, T., additional, Chalmers, J.D., additional, Chambers, R.C., additional, Chan, F., additional, Channon, K.M., additional, Chapman, K., additional, Charalambou, A., additional, Chaudhuri, N., additional, Checkley, A., additional, Chen, J., additional, Cheng, Y., additional, Chetham, L., additional, Childs, C., additional, Chilvers, E.R., additional, Chinoy, H., additional, Chiribiri, A., additional, Chong-James, K., additional, Choudhury, G., additional, Choudhury, N., additional, Chowienczyk, P., additional, Christie, C., additional, Chrystal, M., additional, Clark, D., additional, Clark, C., additional, Clarke, J., additional, Clohisey, S., additional, Coakley, G., additional, Coburn, Z., additional, Coetzee, S., additional, Cole, J., additional, Coleman, C., additional, Conneh, F., additional, Connell, D., additional, Connolly, B., additional, Connor, L., additional, Cook, A., additional, Cooper, B., additional, Cooper, J., additional, Cooper, S., additional, Copeland, D., additional, Cosier, T., additional, Coulding, M., additional, Coupland, C., additional, Cox, E., additional, Craig, T., additional, Crisp, P., additional, Cristiano, D., additional, Crooks, M.G., additional, Cross, A., additional, Cruz, I., additional, Cullinan, P., additional, Cuthbertson, D., additional, Daines, L., additional, Dalton, M., additional, Daly, P., additional, Daniels, A., additional, Dark, P., additional, Dasgin, J., additional, David, A., additional, David, C., additional, Davies, E., additional, Davies, F., additional, Davies, G., additional, Davies, G.A., additional, Davies, K., additional, Davies, M.J., additional, Dawson, J., additional, Daynes, E., additional, De Soyza, A., additional, Deakin, B., additional, Deans, A., additional, Deas, C., additional, Deery, J., additional, Defres, S., additional, Dell, A., additional, Dempsey, K., additional, Denneny, E., additional, Dennis, J., additional, Dewar, A., additional, Dharmagunawardena, R., additional, Diar-Bakerly, N., additional, Dickens, C., additional, Dipper, A., additional, Diver, S., additional, Diwanji, S.N., additional, Dixon, M., additional, Djukanovic, R., additional, Dobson, H., additional, Dobson, S.L., additional, Docherty, A.B., additional, Donaldson, A., additional, Dong, T., additional, Dormand, N., additional, Dougherty, A., additional, Dowling, R., additional, Drain, S., additional, Draxlbauer, K., additional, Drury, K., additional, Dulawan, P., additional, Dunleavy, A., additional, Dunn, S., additional, Dupont, C., additional, Earley, J., additional, Easom, N., additional, Echevarria, C., additional, Edwards, S., additional, Edwardson, C., additional, El-Taweel, H., additional, Elliott, A., additional, Elliott, K., additional, Ellis, Y., additional, Elmer, A., additional, Elneima, O., additional, Evans, D., additional, Evans, H., additional, Evans, J., additional, Evans, R., additional, Evans, R.A., additional, Evans, R.I., additional, Evans, T., additional, Evenden, C., additional, Evison, L., additional, Fabbri, L., additional, Fairbairn, S., additional, Fairman, A., additional, Fallon, K., additional, Faluyi, D., additional, Favager, C., additional, Fayzan, T., additional, Featherstone, J., additional, Felton, T., additional, Finch, J., additional, Finney, S., additional, Finnigan, J., additional, Finnigan, L., additional, Fisher, H., additional, Fletcher, S., additional, Flockton, R., additional, Flynn, M., additional, Foot, H., additional, Foote, D., additional, Ford, A., additional, Forton, D., additional, Fraile, E., additional, Francis, C., additional, Francis, R., additional, Francis, S., additional, Frankel, A., additional, Fraser, E., additional, Free, R., additional, French, N., additional, Fu, X., additional, Fuld, J., additional, Furniss, J., additional, Garner, L., additional, Gautam, N., additional, Geddes, J.R., additional, George, J., additional, George, P., additional, Gibbons, M., additional, Gill, M., additional, Gilmour, L., additional, Gleeson, F., additional, Glossop, J., additional, Glover, S., additional, Goodman, N., additional, Goodwin, C., additional, Gooptu, B., additional, Gordon, H., additional, Gorsuch, T., additional, Greatorex, M., additional, Greenhaff, P.L., additional, Greenhalf, W., additional, Greenhalgh, A., additional, Greening, N.J., additional, Greenwood, J., additional, Gregory, H., additional, Gregory, R., additional, Grieve, D., additional, Griffin, D., additional, Griffiths, L., additional, Guerdette, A-M., additional, Guillen Guio, B., additional, Gummadi, M., additional, Gupta, A., additional, Gurram, S., additional, Guthrie, E., additional, Guy, Z., additional, H Henson, H., additional, Hadley, K., additional, Haggar, A., additional, Hainey, K., additional, Hairsine, B., additional, Haldar, P., additional, Hall, I., additional, Hall, L., additional, Halling-Brown, M., additional, Hamil, R., additional, Hancock, A., additional, Hancock, K., additional, Hanley, N.A., additional, Haq, S., additional, Hardwick, H.E., additional, Hardy, E., additional, Hardy, T., additional, Hargadon, B., additional, Harrington, K., additional, Harris, E., additional, Harris, V.C., additional, Harrison, E.M., additional, Harrison, P., additional, Hart, N., additional, Harvey, A., additional, Harvey, M., additional, Harvie, M., additional, Haslam, L., additional, Havinden-Williams, M., additional, Hawkes, J., additional, Hawkings, N., additional, Haworth, J., additional, Hayday, A., additional, Haynes, M., additional, Hazeldine, J., additional, Hazelton, T., additional, Heaney, L.G., additional, Heeley, C., additional, Heeney, J.L., additional, Heightman, M., additional, Heller, S., additional, Henderson, M., additional, Hesselden, L., additional, Hewitt, M., additional, Highett, V., additional, Hillman, T., additional, Hiwot, T., additional, Ho, L.P., additional, Hoare, A., additional, Hoare, M., additional, Hockridge, J., additional, Hogarth, P., additional, Holbourn, A., additional, Holden, S., additional, Holdsworth, L., additional, Holgate, D., additional, Holland, M., additional, Holloway, L., additional, Holmes, K., additional, Holmes, M., additional, Holroyd-Hind, B., additional, Holt, L., additional, Hormis, A., additional, Horsley, A., additional, Hosseini, A., additional, Hotopf, M., additional, Houchen-Wolloff, L., additional, Howard, K., additional, Howard, L.S., additional, Howell, A., additional, Hufton, E., additional, Hughes, A.D., additional, Hughes, J., additional, Hughes, R., additional, Humphries, A., additional, Huneke, N., additional, Hurditch, E., additional, Hurst, J., additional, Husain, M., additional, Hussell, T., additional, Hutchinson, J., additional, Ibrahim, W., additional, Ilyas, F., additional, Ingham, J., additional, Ingram, L., additional, Ionita, D., additional, Isaacs, K., additional, Ismail, K., additional, Jackson, T., additional, Jacob, J., additional, James, W.Y., additional, Jang, W., additional, Jarman, C., additional, Jarrold, I., additional, Jarvis, H., additional, Jastrub, R., additional, Jayaraman, B., additional, Jenkins, R.G., additional, Jezzard, P., additional, Jiwa, K., additional, Johnson, C., additional, Johnson, S., additional, Johnston, D., additional, Jolley, C.J., additional, Jones, D., additional, Jones, G., additional, Jones, H., additional, Jones, I., additional, Jones, L., additional, Jones, M.G., additional, Jones, S., additional, Jose, S., additional, Kabir, T., additional, Kaltsakas, G., additional, Kamwa, V., additional, Kanellakis, N., additional, Kaprowska, s., additional, Kausar, Z., additional, Keenan, N., additional, Kelly, S., additional, Kemp, G., additional, Kerr, S., additional, Kerslake, H., additional, Key, A.L., additional, Khan, F., additional, Khunti, K., additional, Kilroy, S., additional, King, B., additional, King, C., additional, Kingham, L., additional, Kirk, J., additional, Kitterick, P., additional, Klenerman, P., additional, Knibbs, L., additional, Knight, S., additional, Knighton, A., additional, Kon, O., additional, Kon, S., additional, Kon, S.S., additional, Koprowska, S., additional, Korszun, A., additional, Koychev, I., additional, Kurasz, C., additional, Kurupati, P., additional, Laing, C., additional, Lamlum, H., additional, Landers, G., additional, Langenberg, C., additional, Lasserson, D., additional, Lavelle-Langham, L., additional, Lawrie, A., additional, Lawson, C., additional, Layton, A., additional, Lea, A., additional, Leavy, O.C., additional, Lee, D., additional, Lee, J-H., additional, Lee, E., additional, Leitch, K., additional, Lenagh, R., additional, Lewis, D., additional, Lewis, J., additional, Lewis, K.E., additional, Lewis, V., additional, Lewis-Burke, N., additional, Li, X., additional, Light, T., additional, Lightstone, L., additional, Lilaonitkul, W., additional, Lim, L., additional, Linford, S., additional, Lingford-Hughes, A., additional, Lipman, M., additional, Liyanage, K., additional, Lloyd, A., additional, Logan, S., additional, Lomas, D., additional, Lone, N.I., additional, Loosley, R., additional, Lord, J.M., additional, Lota, H., additional, Lovegrove, W., additional, Lucey, A., additional, Lukaschuk, E., additional, Lye, A., additional, Lynch, C., additional, MacDonald, S., additional, MacGowan, G., additional, Macharia, I., additional, Mackie, J., additional, Macliver, L., additional, Madathil, S., additional, Madzamba, G., additional, Magee, N., additional, Magtoto, M.M., additional, Mairs, N., additional, Majeed, N., additional, Major, E., additional, Malein, F., additional, Malim, M., additional, Mallison, G., additional, Man, W.D.-C., additional, Mandal, S., additional, Mangion, K., additional, Manisty, C., additional, Manley, R., additional, March, K., additional, Marciniak, S., additional, Marino, P., additional, Mariveles, M., additional, Marks, M., additional, Marouzet, E., additional, Marsh, S., additional, Marshall, B., additional, Marshall, M., additional, Martin, J., additional, Martineau, A., additional, Martinez, L.M., additional, Maskell, N., additional, Matila, D., additional, Matimba-Mupaya, W., additional, Matthews, L., additional, Mbuyisa, A., additional, McAdoo, S., additional, McAllister-Williams, H., additional, McArdle, A., additional, McArdle, P., additional, McAulay, D., additional, McCann, G.P., additional, drury, H.J.C., additional, McCormick, J., additional, McCormick, W., additional, McCourt, P., additional, McGarvey, L., additional, McGee, C., additional, Mcgee, K., additional, McGinness, J., additional, McGlynn, K., additional, McGovern, A., additional, McGuinness, H., additional, McInnes, I.B., additional, McIntosh, J., additional, McIvor, E., additional, McIvor, K., additional, McLeavey, L., additional, McMahon, A., additional, McMahon, M.J., additional, McMorrow, L., additional, Mcnally, T., additional, McNarry, M., additional, McNeill, J., additional, McQueen, A., additional, McShane, H., additional, Mears, C., additional, Megson, C., additional, Megson, S., additional, Mehta, P., additional, Meiring, J., additional, Melling, L., additional, Mencias, M., additional, Menzies, D., additional, Merida Morillas, M., additional, Michael, A., additional, Miller, C., additional, Milligan, L., additional, Mills, C., additional, Mills, N.L., additional, Milner, L., additional, Misra, S., additional, Mitchell, J., additional, Mohamed, A., additional, Mohamed, N., additional, Mohammed, S., additional, Molyneaux, P.L., additional, Monteiro, W., additional, Moriera, S., additional, Morley, A., additional, Morrison, L., additional, Morriss, R., additional, Morrow, A., additional, Moss, A.J., additional, Moss, P., additional, Motohashi, K., additional, Msimanga, N., additional, Mukaetova-Ladinska, E., additional, Munawar, U., additional, Murira, J., additional, Nanda, U., additional, Nassa, H., additional, Nasseri, M., additional, Neal, A., additional, Needham, R., additional, Neill, P., additional, Neubauer, S., additional, Newby, D.E., additional, Newell, H., additional, Newman, T., additional, Newton-Cox, A., additional, Nicholson, T., additional, Nicoll, D., additional, Nikolaidis, A., additional, Nolan, C.M., additional, Noonan, M.J., additional, Norman, C., additional, Novotny, P., additional, Nunag, J., additional, Nwafor, L., additional, Nwanguma, U., additional, Nyaboko, J., additional, O'Brien, C., additional, O'Donnell, K., additional, O'Regan, D., additional, O'Brien, L., additional, Odell, N., additional, Ogg, G., additional, Olaosebikan, O., additional, Oliver, C., additional, Omar, Z., additional, Openshaw, P.J.M., additional, Orriss-Dib, L., additional, Osborne, L., additional, Osbourne, R., additional, Ostermann, M., additional, Overton, C., additional, Owen, J., additional, Oxton, J., additional, Pack, J., additional, Pacpaco, E., additional, Paddick, S., additional, Painter, S., additional, Pakzad, A., additional, Palmer, S., additional, Papineni, P., additional, Paques, K., additional, Paradowski, K., additional, Pareek, M., additional, Parekh, D., additional, Parfrey, H., additional, Pariante, C., additional, Parker, S., additional, Parkes, M., additional, Parmar, J., additional, Patale, S., additional, Patel, B., additional, Patel, M., additional, Patel, S., additional, Pattenadk, D., additional, Pavlides, M., additional, Payne, S., additional, Pearce, L., additional, Pearl, J.E., additional, Peckham, D., additional, Pendlebury, J., additional, Peng, Y., additional, Pennington, C., additional, Peralta, I., additional, Perkins, E., additional, Peterkin, Z., additional, Peto, T., additional, Petousi, N., additional, Petrie, J., additional, Pfeffer, P., additional, Phipps, J., additional, Pimm, J., additional, Piper Hanley, K., additional, Pius, R., additional, Plant, H., additional, Plein, S., additional, Plekhanova, T., additional, Plowright, M., additional, Poinasamy, K., additional, Polgar, O., additional, Poll, L., additional, Porter, J.C., additional, Porter, J., additional, Portukhay, S., additional, Powell, N., additional, Prabhu, A., additional, Pratt, J., additional, Price, A., additional, Price, C., additional, Price, D., additional, Price, L., additional, Prickett, A., additional, Propescu, J., additional, Prosper, S., additional, Pugmire, S., additional, Quaid, S., additional, Quigley, J., additional, Quint, J., additional, Qureshi, H., additional, Qureshi, I.N., additional, Radhakrishnan, K., additional, Rahman, N.M., additional, Ralser, M., additional, Raman, B., additional, Ramos, A., additional, Ramos, H., additional, Rangeley, J., additional, Rangelov, B., additional, Ratcliffe, L., additional, Ravencroft, P., additional, Reddington, A., additional, Reddy, R., additional, Redfearn, H., additional, Redwood, D., additional, Reed, A., additional, Rees, M., additional, Rees, T., additional, Regan, K., additional, Reynolds, W., additional, Ribeiro, C., additional, Richards, A., additional, Richardson, E., additional, Richardson, M., additional, Rivera-Ortega, P., additional, Roberts, K., additional, Robertson, E., additional, Robinson, E., additional, Robinson, L., additional, Roche, L., additional, Roddis, C., additional, Rodger, J., additional, Ross, A., additional, Ross, G., additional, Rossdale, J., additional, Rostron, A., additional, Rowe, A., additional, Rowland, A., additional, Rowland, J., additional, Rowland, M.J., additional, Rowland-Jones, S.L., additional, Roy, K., additional, Roy, M., additional, Rudan, I., additional, Russell, R., additional, Russell, E., additional, Saalmink, G., additional, Sabit, R., additional, Sage, E.K., additional, Samakomva, T., additional, Samani, N., additional, Sampson, C., additional, Samuel, K., additional, Samuel, R., additional, Sanderson, A., additional, Sapey, E., additional, Saralaya, D., additional, Sargant, J., additional, Sarginson, C., additional, Sass, T., additional, Sattar, N., additional, Saunders, K., additional, Saunders, R.M., additional, Saunders, P., additional, Saunders, L.C., additional, Savill, H., additional, Saxon, W., additional, Sayer, A., additional, Schronce, J., additional, Schwaeble, W., additional, Scott, J.T., additional, Scott, K., additional, Selby, N., additional, Semple, M.G., additional, Sereno, M., additional, Sewell, T.A., additional, Shah, A., additional, Shah, K., additional, Shah, P., additional, Shankar-Hari, M., additional, Sharma, M., additional, Sharpe, C., additional, Sharpe, M., additional, Shashaa, S., additional, Shaw, A., additional, Shaw, K., additional, Shaw, V., additional, Sheikh, A., additional, Shelton, S., additional, Shenton, L., additional, Shevket, K., additional, Shikotra, A., additional, Short, J., additional, Siddique, S., additional, Siddiqui, S., additional, Sidebottom, J., additional, Sigfrid, L., additional, Simons, G., additional, Simpson, J., additional, Simpson, N., additional, Singapuri, A., additional, Singh, C., additional, Singh, S., additional, Singh, S.J., additional, Sissons, D., additional, Skeemer, J., additional, Slack, K., additional, Smith, A., additional, Smith, D., additional, Smith, S., additional, Smith, J., additional, Smith, L., additional, Soares, M., additional, Solano, T.S., additional, Solly, R., additional, Solstice, A.R., additional, Soulsby, T., additional, Southern, D., additional, Sowter, D., additional, Spears, M., additional, Spencer, L.G., additional, Speranza, F., additional, Stadon, L., additional, Stanel, S., additional, Steele, N., additional, Steiner, M., additional, Stensel, D., additional, Stephens, G., additional, Stephenson, L., additional, Stern, M., additional, Stewart, I., additional, Stimpson, R., additional, Stockdale, S., additional, Stockley, J., additional, Stoker, W., additional, Stone, R., additional, Storrar, W., additional, Storrie, A., additional, Storton, K., additional, Stringer, E., additional, Strong-Sheldrake, S., additional, Stroud, N., additional, Subbe, C., additional, Sudlow, C.L., additional, Suleiman, Z., additional, Summers, C., additional, Summersgill, C., additional, Sutherland, D., additional, Sykes, D.L., additional, Sykes, R., additional, Talbot, N., additional, Tan, A.L., additional, Tarusan, L., additional, Tavoukjian, V., additional, Taylor, A., additional, Taylor, C., additional, Taylor, J., additional, Te, A., additional, Tedd, H., additional, Tee, C.J., additional, Teixeira, J., additional, Tench, H., additional, Terry, S., additional, Thackray-Nocera, S., additional, Thaivalappil, F., additional, Thamu, B., additional, Thickett, D., additional, Thomas, C., additional, Thomas, D.C., additional, Thomas, S., additional, Thomas, A.K., additional, Thomas-Woods, T., additional, Thompson, T., additional, Thompson, A.A.R., additional, Thornton, T., additional, Thorpe, M., additional, Thwaites, R.S., additional, Tilley, J., additional, Tinker, N., additional, Tiongson, G.F., additional, Tobin, M., additional, Tomlinson, J., additional, Tong, C., additional, Toshner, M., additional, Touyz, R., additional, Tripp, K.A., additional, Tunnicliffe, E., additional, Turnbull, A., additional, Turner, E., additional, Turner, S., additional, Turner, V., additional, Turner, K., additional, Turney, S., additional, Turtle, L., additional, Turton, H., additional, Ugoji, J., additional, Ugwuoke, R., additional, Upthegrove, R., additional, Valabhji, J., additional, Ventura, M., additional, Vere, J., additional, Vickers, C., additional, Vinson, B., additional, Wade, E., additional, Wade, P., additional, Wain, L.V., additional, Wainwright, T., additional, Wajero, L.O., additional, Walder, S., additional, Walker, S., additional, Wall, E., additional, Wallis, T., additional, Walmsley, S., additional, Walsh, J.A., additional, Walsh, S., additional, Warburton, L., additional, Ward, T.J.C., additional, Warwick, K., additional, Wassall, H., additional, Waterson, S., additional, Watson, E., additional, Watson, L., additional, Watson, J., additional, Weir McCall, J., additional, Welch, C., additional, Welch, H., additional, Welsh, B., additional, Wessely, S., additional, West, S., additional, Weston, H., additional, Wheeler, H., additional, White, S., additional, Whitehead, V., additional, Whitney, J., additional, Whittaker, S., additional, Whittam, B., additional, Whitworth, V., additional, Wight, A., additional, Wild, J., additional, Wilkins, M., additional, Wilkinson, D., additional, Williams, B., additional, Williams, N., additional, Williams, J., additional, Williams-Howard, S.A., additional, Willicombe, M., additional, Willis, G., additional, Willoughby, J., additional, Wilson, A., additional, Wilson, D., additional, Wilson, I., additional, Window, N., additional, Witham, M., additional, Wolf-Roberts, R., additional, Wood, C., additional, Woodhead, F., additional, Woods, J., additional, Wootton, D.G., additional, Wormleighton, J., additional, Worsley, J., additional, Wraith, D., additional, Wrey Brown, C., additional, Wright, C., additional, Wright, L., additional, Wright, S., additional, Wyles, J., additional, Wynter, I., additional, Xu, M., additional, Yasmin, N., additional, Yasmin, S., additional, Yates, T., additional, Yip, K.P., additional, Young, B., additional, Young, S., additional, Young, A., additional, Yousuf, A.J., additional, Zawia, A., additional, Zeidan, L., additional, Zhao, B., additional, Zheng, B., additional, and Zongo, O., additional

Published
2023
Full Text
View/download PDF

21. Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19

Author

Daines, L, Zheng, B, Elneima, O, Harrison, E, Lone, NI, Hurst, JR, Brown, JS, Sapey, E, Chalmers, JD, Quint, JK, Pfeffer, P, Siddiqui, S, Walker, S, Poinasamy, K, McAuley, H, Sereno, M, Shikotra, A, Singapuri, A, Docherty, AB, Marks, M, Toshner, M, Howard, LS, Horsley, A, Jenkins, G, Porter, JC, Ho, L-P, Raman, B, Wain, LV, Brightling, CE, Evans, RA, Heaney, LG, De Soyza, A, Sheikh, A, Daines, Luke [0000-0003-0564-4000], Lone, Nazir I [0000-0003-2707-2779], Hurst, John R [0000-0002-7246-6040], Sapey, Elizabeth [0000-0003-3454-5482], Quint, Jennifer K [0000-0003-0149-4869], McAuley, Hamish [0000-0001-8997-0764], Marks, Michael [0000-0002-7585-4743], Toshner, Mark [0000-0002-3969-6143], Howard, Luke S [0000-0003-2822-210X], Horsley, Alex [0000-0003-1828-0058], Porter, Joanna C [0000-0002-7307-169X], Raman, Betty [0000-0002-1239-9608], Wain, Louise V [0000-0003-4951-1867], Evans, Rachael A [0000-0002-1667-868X], De Soyza, Anthony [0000-0002-8566-0344], and Apollo - University of Cambridge Repository

Subjects
Pulmonary and Respiratory Medicine, Mental Health, Clinical Research, Behavioral and Social Science, Respiratory, 32 Biomedical and Clinical Sciences, 3 Good Health and Well Being, 3202 Clinical Sciences, Respiratory infections and tuberculosis, Brain Disorders
Abstract

Funder: UK Health Data Research BREATHE Hub, BACKGROUND: Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation. METHODS: PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19. Clinical data were collected during hospitalisation and at a follow-up visit. Breathlessness was measured by a numeric rating scale of 0-10. We defined post-COVID-19 breathlessness as an increase in score of ≥1 compared to the pre-COVID-19 level. Multivariable logistic regression was used to identify risk factors and to develop a prediction model for post-COVID-19 breathlessness. RESULTS: We included 1226 participants (37% female, median age 59 years, 22% mechanically ventilated). At a median 5 months after discharge, 50% reported post-COVID-19 breathlessness. Risk factors for post-COVID-19 breathlessness were socioeconomic deprivation (adjusted OR 1.67, 95% CI 1.14-2.44), pre-existing depression/anxiety (adjusted OR 1.58, 95% CI 1.06-2.35), female sex (adjusted OR 1.56, 95% CI 1.21-2.00) and admission duration (adjusted OR 1.01, 95% CI 1.00-1.02). Black ethnicity (adjusted OR 0.56, 95% CI 0.35-0.89) and older age groups (adjusted OR 0.31, 95% CI 0.14-0.66) were less likely to report post-COVID-19 breathlessness. Post-COVID-19 breathlessness was associated with worse performance on the shuttle walk test and forced vital capacity, but not with obstructive airflow limitation. The prediction model had fair discrimination (concordance statistic 0.66, 95% CI 0.63-0.69) and good calibration (calibration slope 1.00, 95% CI 0.80-1.21). CONCLUSIONS: Post-COVID-19 breathlessness was commonly reported in this national cohort of patients hospitalised for COVID-19 and is likely to be a multifactorial problem with physical and emotional components.

Published
2023
Full Text
View/download PDF

24. S94 Dysfunctional neutrophil response in COVID-19 infection vary by subtype

Author

Thein, OS, primary, Belchamber, KBR, additional, Faniyi, AA, additional, Hazeldine, J, additional, Grudzinska, FS, additional, Hughes, MJ, additional, Jasper, AE, additional, Crowley, L, additional, Yip, KP, additional, Lugg, S, additional, Sapey, E, additional, Parekh, D, additional, Thickett, DR, additional, and Scott, A, additional

Published
2022
Full Text
View/download PDF

26. Characteristics and risk factors for persistent breathlessness after hospitalisation for COVID-19

Author

Daines, L, primary, Zheng, B, additional, Elneima, O, additional, Hurst, J R, additional, Brown, J, additional, Sapey, E, additional, Chalmers, J D, additional, Quint, J K, additional, Pfeffer, P, additional, Siddiqui, S, additional, Walker, S, additional, Poinasamy, K, additional, Wain, L V, additional, Brightling, C E, additional, Evans, R A, additional, Heaney, L G, additional, De Soyza, A, additional, and Sheikh, A, additional

Published
2022
Full Text
View/download PDF

30. Catching “Early” COPD – The Diagnostic Conundrum

Author

Yip KP, Stockley RA, and Sapey E

Subjects
lcsh:RC705-779, early, neutrophil, biomarker, copd, lung function, lcsh:Diseases of the respiratory system, respiratory tract diseases
Abstract

Kay Por Yip,1 Robert A Stockley,2 Elizabeth Sapey1 1Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham, UK; 2Department of Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham, UKCorrespondence: Kay Por Yip Email K.P.Yip@bham.ac.ukAbstract: Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide. Despite this, there has been little progress so far in terms of disease-modifying therapies over the last few decades and this is in part due to poor understanding of the definition and mechanisms surrounding early disease before it becomes established and increasingly complex. In this review, the nuances and difficulty in defining early disease in COPD are discussed. There are clear benefits in identifying patients early; however, usually diagnosis is made in the presence of significant lung damage. We consider what can be learned of early disease from COPD studies and highlight the lack of inclusion of young smokers (who may be at risk of COPD) or those with mild disease. We discuss promising clinical measures that are being used in an effort to detect early disease. These include symptom assessment, lung physiology measures and computed tomography (CT) imaging modalities. There is emerging evidence for the role of neutrophils and their proteinases in early COPD. This may form an important biomarker to investigate the pathophysiological processes of early COPD. Given the importance of the early disease, it is recommended that future COPD studies focus on capturing the earliest manifestations of disease, to understand the initiating mechanisms and to identify novel treatment targets.Keywords: COPD, early, neutrophil, lung function, biomarker

Published
2021

31. There is No Fast Track to Identify Fast Decliners in Alpha-1 Antitrypsin Deficiency by Spirometry: A Longitudinal Study of Repeated Measurements

Author

Stockley JA, Stockley RA, and Sapey E

Subjects
lcsh:RC705-779, lung function, alpha 1 antitrypsin deficiency, lcsh:Diseases of the respiratory system, obstructive airways disease, decline
Abstract

James A Stockley,1 Robert A Stockley,2 Elizabeth Sapey3 1Lung Function & Sleep Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK; 2Respiratory Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK; 3PIONEER Health Data Hub in Acute Care, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2GW, UKCorrespondence: Elizabeth SapeyPIONEER Health Data Hub in Acute Care, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham, B15 2GW, UKEmail E.sapey@bham.ac.ukBackground: It is known that lung function decline in Alpha-1 Antitrypsin Deficiency (AATD) varies. Those with a rapid decline are at highest risk of poorer outcomes but may benefit most from targeted treatments including augmentation therapy. Current evidence suggests rapid decliners can be identified after 3 years of serial follow-up. It would be advantageous to identify these patients over a shorter time period, especially in mild disease.Methods: Post-bronchodilator spirometry was performed every 6 months for a total of 18 months (4 measurements) by PiZZ AATD patients (ex- or never-smokers) either without spirometric COPD or with mild COPD. Where possible, retrospective spirometry data were included. Decline was assessed using 2 (baseline and 6 month) or four measurements (including baseline, 6, 12 and 18 months) and compared to retrospective decline rates using annual measurements over 3 years.Results: Seventy-two PiZZ AATD patients were included, with 27 having at least three years of retrospective, annual spirometry. 18-month progression obtained by linear regression showed variable degrees of change with 29 showing no decline, 8 showing slow decline and 35 showing rapid decline. Bland-Altman plots showed that there was no overall agreement between predicted rate of decline using data obtained over 6 months and that obtained over 18 months. Furthermore, there was no agreement between rate of decline from either 6 or 18 months’ data when compared to data collected over 3 years. The positive predictive value for rapid decline with 18 months of data compared to 3 years was only 50.0%.Conclusion: This study suggests serial lung function over 18 months cannot identify AATD patients who have rapidly declining lung function. There is an urgent need for different biomarkers to help identify these patients at the earliest opportunity.Keywords: lung function, decline, obstructive airways disease, alpha-1 antitrypsin deficiency

Published
2021

36. Monocytes and Macrophages in Alpha-1 Antitrypsin Deficiency

Author

Belchamber KBR, Walker EM, Stockley RA, and Sapey E

Subjects
lcsh:RC705-779, congenital, hereditary, and neonatal diseases and abnormalities, monocyte macrophage alpha-1 antitrypsin alpha-1 antitrypsin deficiency, lcsh:Diseases of the respiratory system
Abstract

Kylie BR Belchamber,1 Eloise M Walker,1 Robert A Stockley,1 Elizabeth Sapey1,2 1Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK; 2NIHR Clinical Research Facility Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UKCorrespondence: Kylie BR BelchamberBirmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UKEmail k.belchamber@bham.ac.ukAbstract: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition characterised by low circulating levels of alpha-1 antitrypsin (AAT), a serine proteinase inhibitor. The most common deficiency variants are the S and Z mutations, which cause the accumulation of misfolded AAT in hepatocytes resulting in endoplasmic reticular stress and insufficient release of AAT into the circulation (< 11μmol/L). This leads to liver disease, as well as an increased risk of emphysema due to unopposed proteolytic activity of neutrophil-derived serine proteinases in the lungs. AATD has been traditionally viewed as an inflammatory disorder caused directly by a proteinase-antiproteinase imbalance in the lung, but increasing evidence suggests that low AAT levels may affect other cellular functions. Recently, AAT polymers have been identified in both monocytes and macrophages from AATD patients and evidence is building that these cells may also play a role in the development of AATD lung disease. Alveolar macrophages are phagocytic cells that are important in the lung immune response but are also implicated in driving inflammation. This review explores the potential implications of monocyte and macrophage involvement in non-liver AAT synthesis and the pathophysiology of AATD lung disease.Keywords: monocyte, macrophage, alpha-1 antitrypsin, alpha-1 antitrypsin deficiency

Published
2020

38. Hypoxia increases the potential for neutrophil-mediated endothelial damage in COPD

Author

Lodge, K, Vassallo, A, Liu, B, Long, M, Tong, Z, Newby, P, Agha-Jaffar, D, Paschalaki, K, Green, C, Belchamber, K, Ridger, V, Stockley, R, Sapey, E, Summers, C, Cowburn, A, Chilvers, E, Li, W, Condliffe, A, National Heart and Lung Foundation, The Academy of Medical Sciences, and British Heart Foundation

Subjects
Neutrophils, Respiratory System, DEGRANULATION, EMPHYSEMA, Pulmonary Disease, Chronic Obstructive, Critical Care Medicine, GELATINASE-ASSOCIATED LIPOCALIN, cardiovascular disease, General & Internal Medicine, SPUTUM, Humans, Hypoxia, 11 Medical and Health Sciences, AIRWAYS, Science & Technology, CYCLOPHILIN, Endothelial Cells, cell degranulation, Vascular System Injuries, respiratory tract diseases, PLATELET-ACTIVATING-FACTOR, SECRETION, Leukocyte Elastase, Life Sciences & Biomedicine, neutrophil elastase, vascular endothelium, ELASTASE, SMOKERS
Abstract

Rationale: Chronic obstructive pulmonary disease (COPD) patients experience excess cardiovascular morbidity and mortality, and exacerbations further increase the risk of such events. COPD is associated with persistent blood and airway neutrophilia, and systemic and tissue hypoxia. Hypoxia augments neutrophil elastase release, enhancing capacity for tissue injury. Objective: To determine whether hypoxia-driven neutrophil protein secretion contributes to endothelial damage in COPD. Methods: The healthy human neutrophil secretome generated under normoxic or hypoxic conditions was characterised by quantitative mass spectrometry, and the capacity for neutrophil-mediated endothelial damage assessed. Histotoxic protein levels were measured in normoxic versus hypoxic neutrophil supernatants and plasma from exacerbating COPD patients and healthy controls. Main results: Hypoxia promoted PI3Kγ-dependent neutrophil elastase secretion, with greater release seen in neutrophils from COPD patients. Supernatants from neutrophils incubated under hypoxia caused pulmonary endothelial cell damage and identical supernatants from COPD neutrophils increased neutrophil adherence to endothelial cells. Proteomics revealed differential neutrophil protein secretion under hypoxia and normoxia; hypoxia augmented secretion of a subset of histotoxic granule and cytosolic proteins, with significantly greater release seen in COPD neutrophils. The plasma of COPD patients had higher content of hypoxia-upregulated neutrophil-derived proteins and protease activity, and vascular injury markers. Conclusions: Hypoxia drives a destructive ‘hyper-secretory’ neutrophil phenotype conferring enhanced capacity for endothelial injury, with a corresponding signature of neutrophil degranulation and vascular injury identified in COPD patient plasma. Thus, hypoxic enhancement of neutrophil degranulation may contribute to increased cardiovascular risk in COPD. These insights may identify new therapeutic opportunities for endothelial damage in COPD.

Published
2021

39. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Author

Evans, Rachael A, primary, McAuley, Hamish, additional, Harrison, Ewen M, additional, Shikotra, Aarti, additional, Singapuri, Amisha, additional, Sereno, Marco, additional, Elneima, Omer, additional, Docherty, Annemarie B, additional, Lone, Nazir I, additional, Leavy, Olivia C, additional, Daines, Luke, additional, Baillie, J Kenneth, additional, Brown, Jeremy S, additional, Chalder, Trudie, additional, De Soyza, Anthony, additional, Diar Bakerly, Nawar, additional, Easom, Nicholas, additional, Geddes, John R, additional, Greening, Neil J, additional, Hart, Nick, additional, Heaney, Liam G, additional, Heller, Simon, additional, Howard, Luke, additional, Hurst, John R, additional, Jacob, Joseph, additional, Jenkins, R Gisli, additional, Jolley, Caroline, additional, Kerr, Steven, additional, Kon, Onn M, additional, Lewis, Keir, additional, Lord, Janet M, additional, McCann, Gerry P, additional, Neubauer, Stefan, additional, Openshaw, Peter J M, additional, Parekh, Dhruv, additional, Pfeffer, Paul, additional, Rahman, Najib M, additional, Raman, Betty, additional, Richardson, Matthew, additional, Rowland, Matthew, additional, Semple, Malcolm G, additional, Shah, Ajay M, additional, Singh, Sally J, additional, Sheikh, Aziz, additional, Thomas, David, additional, Toshner, Mark, additional, Chalmers, James D, additional, Ho, Ling-Pei, additional, Horsley, Alex, additional, Marks, Michael, additional, Poinasamy, Krisnah, additional, Wain, Louise V, additional, Brightling, Christopher E, additional, Abel, K, additional, Adamali, H, additional, Adeloye, D, additional, Adeyemi, O, additional, Adeyemi, F, additional, Ahmad, S, additional, Ahmed, R, additional, Ainsworth, M, additional, Alamoudi, A, additional, Aljaroof, M, additional, Allan, L, additional, Allen, R, additional, Alli, A, additional, Al-Sheklly, B, additional, Altmann, D, additional, Anderson, D, additional, Andrews, M, additional, Angyal, A, additional, Antoniades, C, additional, Arbane, G, additional, Armour, C, additional, Armstrong, N, additional, Armstrong, L, additional, Arnold, H, additional, Arnold, D, additional, Ashworth, M, additional, Ashworth, A, additional, Assefa-Kebede, H, additional, Atkin, P, additional, Atkins, H, additional, Atkins, A, additional, Aul, R, additional, Avram, C, additional, Baggott, R, additional, Baguley, D, additional, Baillie, J K, additional, Bain, S, additional, Bakali, M, additional, Bakau, M, additional, Baldry, E, additional, Baldwin, D, additional, Ballard, C, additional, Bambrough, J, additional, Barker, R E, additional, Barratt, S, additional, Barrett, F, additional, Basu, N, additional, Batterham, R, additional, Baxendale, H, additional, Bayes, H, additional, Bayley, M, additional, Beadsworth, M, additional, Beirne, P, additional, Bell, R, additional, Bell, D, additional, Berry, C, additional, Betts, S, additional, Bhui, K, additional, Bishop, L, additional, Blaikely, J, additional, Bloomfield, C, additional, Bloss, A, additional, Bolger, A, additional, Bolton, C E, additional, Bonnington, J, additional, Botkai, A, additional, Bourne, M, additional, Bourne, C, additional, Bradley, E, additional, Bramham, K, additional, Brear, L, additional, Breen, G, additional, Breeze, J, additional, Briggs, A, additional, Bright, E, additional, Brightling, C E, additional, Brill, S, additional, Brindle, K, additional, Broad, L, additional, Broome, M, additional, Brown, J S, additional, Brown, M, additional, Brown, J, additional, Brown, R, additional, Brown, V, additional, Brown, A, additional, Brugha, T, additional, Brunskill, N, additional, Buch, M, additional, Bularga, A, additional, Bullmore, E, additional, Burn, D, additional, Burns, G, additional, Busby, J, additional, Buttress, A, additional, Byrne, S, additional, Cairns, P, additional, Calder, P C, additional, Calvelo, E, additional, Card, B, additional, Carr, L, additional, Carson, G, additional, Carter, P, additional, Cavanagh, J, additional, Chalder, T, additional, Chalmers, J D, additional, Chambers, R C, additional, Channon, K, additional, Chapman, K, additional, Charalambou, A, additional, Chaudhuri, N, additional, Checkley, A, additional, Chen, J, additional, Chetham, L, additional, Chilvers, E R, additional, Chinoy, H, additional, Chong-James, K, additional, Choudhury, N, additional, Choudhury, G, additional, Chowdhury, P, additional, Chowienczyk, P, additional, Christie, C, additional, Clark, D, additional, Clark, C, additional, Clarke, J, additional, Clift, P, additional, Clohisey, S, additional, Coburn, Z, additional, Cole, J, additional, Coleman, C, additional, Connell, D, additional, Connolly, B, additional, Connor, L, additional, Cook, A, additional, Cooper, B, additional, Coupland, C, additional, Craig, T, additional, Crisp, P, additional, Cristiano, D, additional, Crooks, M G, additional, Cross, A, additional, Cruz, I, additional, Cullinan, P, additional, Daines, L, additional, Dalton, M, additional, Dark, P, additional, Dasgin, J, additional, David, A, additional, David, C, additional, Davies, M, additional, Davies, G, additional, Davies, K, additional, Davies, F, additional, Davies, G A, additional, Daynes, E, additional, De Silva, T, additional, De Soyza, A, additional, Deakin, B, additional, Deans, A, additional, Defres, S, additional, Dell, A, additional, Dempsey, K, additional, Dennis, J, additional, Dewar, A, additional, Dharmagunawardena, R, additional, Diar Bakerly, N, additional, Dipper, A, additional, Diver, S, additional, Diwanji, S N, additional, Dixon, M, additional, Djukanovic, R, additional, Dobson, H, additional, Dobson, C, additional, Dobson, S L, additional, Docherty, A B, additional, Donaldson, A, additional, Dong, T, additional, Dormand, N, additional, Dougherty, A, additional, Dowling, R, additional, Drain, S, additional, Dulawan, P, additional, Dunn, S, additional, Easom, N, additional, Echevarria, C, additional, Edwards, S, additional, Edwardson, C, additional, Elliott, B, additional, Elliott, A, additional, Ellis, Y, additional, Elmer, A, additional, Elneima, O, additional, Evans, R A, additional, Evans, J, additional, Evans, H, additional, Evans, D, additional, Evans, R I, additional, Evans, R, additional, Evans, T, additional, Fabbri, L, additional, Fairbairn, S, additional, Fairman, A, additional, Fallon, K, additional, Faluyi, D, additional, Favager, C, additional, Felton, T, additional, Finch, J, additional, Finney, S, additional, Fisher, H, additional, Fletcher, S, additional, Flockton, R, additional, Foote, D, additional, Ford, A, additional, Forton, D, additional, Francis, R, additional, Francis, S, additional, Francis, C, additional, Frankel, A, additional, Fraser, E, additional, Free, R, additional, French, N, additional, Fuld, J, additional, Furniss, J, additional, Garner, L, additional, Gautam, N, additional, Geddes, J R, additional, George, P M, additional, George, J, additional, Gibbons, M, additional, Gilmour, L, additional, Gleeson, F, additional, Glossop, J, additional, Glover, S, additional, Goodman, N, additional, Gooptu, B, additional, Gorsuch, T, additional, Gourlay, E, additional, Greenhaff, P, additional, Greenhalf, W, additional, Greenhalgh, A, additional, Greening, N J, additional, Greenwood, J, additional, Greenwood, S, additional, Gregory, R, additional, Grieve, D, additional, Gummadi, M, additional, Gupta, A, additional, Gurram, S, additional, Guthrie, E, additional, Hadley, K, additional, Haggar, A, additional, Hainey, K, additional, Haldar, P, additional, Hall, I, additional, Hall, L, additional, Halling-Brown, M, additional, Hamil, R, additional, Hanley, N A, additional, Hardwick, H, additional, Hardy, E, additional, Hargadon, B, additional, Harrington, K, additional, Harris, V, additional, Harrison, E M, additional, Harrison, P, additional, Hart, N, additional, Harvey, A, additional, Harvey, M, additional, Harvie, M, additional, Havinden-Williams, M, additional, Hawkes, J, additional, Hawkings, N, additional, Haworth, J, additional, Hayday, A, additional, Heaney, L G, additional, Heeney, J L, additional, Heightman, M, additional, Heller, S, additional, Henderson, M, additional, Hesselden, L, additional, Hillman, T, additional, Hingorani, A, additional, Hiwot, T, additional, Ho, L P, additional, Hoare, A, additional, Hoare, M, additional, Hogarth, P, additional, Holbourn, A, additional, Holdsworth, L, additional, Holgate, D, additional, Holmes, K, additional, Holroyd-Hind, B, additional, Horsley, A, additional, Hosseini, A, additional, Hotopf, M, additional, Houchen, L, additional, Howard, L, additional, Howell, A, additional, Hufton, E, additional, Hughes, A, additional, Hughes, J, additional, Hughes, R, additional, Humphries, A, additional, Huneke, N, additional, Hurst, J R, additional, Hurst, R, additional, Husain, M, additional, Hussell, T, additional, Ibrahim, W, additional, Ient, A, additional, Ingram, L, additional, Ismail, K, additional, Jackson, T, additional, Jacob, J, additional, James, W Y, additional, Janes, S, additional, Jarvis, H, additional, Jayaraman, B, additional, Jenkins, R G, additional, Jezzard, P, additional, Jiwa, K, additional, Johnson, S, additional, Johnson, C, additional, Johnston, D, additional, Jolley, C, additional, Jolley, C J, additional, Jones, I, additional, Jones, S, additional, Jones, D, additional, Jones, H, additional, Jones, G, additional, Jones, M, additional, Jose, S, additional, Kabir, T, additional, Kaltsakas, G, additional, Kamwa, V, additional, Kar, P, additional, Kausar, Z, additional, Kelly, S, additional, Kerr, S, additional, Key, A L, additional, Khan, F, additional, Khunti, K, additional, King, C, additional, King, B, additional, Kitterick, P, additional, Klenerman, P, additional, Knibbs, L, additional, Knight, S, additional, Knighton, A, additional, Kon, O M, additional, Kon, S, additional, Kon, S S, additional, Korszun, A, additional, Kotanidis, C, additional, Koychev, I, additional, Kurupati, P, additional, Kwan, J, additional, Laing, C, additional, Lamlum, H, additional, Landers, G, additional, Langenberg, C, additional, Lasserson, D, additional, Lawrie, A, additional, Lea, A, additional, Leavy, O C, additional, Lee, D, additional, Lee, E, additional, Leitch, K, additional, Lenagh, R, additional, Lewis, K, additional, Lewis, V, additional, Lewis, K E, additional, Lewis, J, additional, Lewis-Burke, N, additional, Light, T, additional, Lightstone, L, additional, Lim, L, additional, Linford, S, additional, Lingford-Hughes, A, additional, Lipman, M, additional, Liyanage, K, additional, Lloyd, A, additional, Logan, S, additional, Lomas, D, additional, Lone, N I, additional, Loosley, R, additional, Lord, J M, additional, Lota, H, additional, Lucey, A, additional, MacGowan, G, additional, Macharia, I, additional, Mackay, C, additional, Macliver, L, additional, Madathil, S, additional, Madzamba, G, additional, Magee, N, additional, Mairs, N, additional, Majeed, N, additional, Major, E, additional, Malim, M, additional, Mallison, G, additional, Man, W, additional, Mandal, S, additional, Mangion, K, additional, Mansoori, P, additional, Marciniak, S, additional, Mariveles, M, additional, Marks, M, additional, Marshall, B, additional, Martineau, A, additional, Maskell, N, additional, Matila, D, additional, Matthews, L, additional, Mayet, J, additional, McAdoo, S, additional, McAllister-Williams, H, additional, McArdle, P, additional, McArdle, A, additional, McAulay, D, additional, McAuley, H, additional, McAuley, D F, additional, McCafferty, K, additional, McCann, G P, additional, McCauley, H, additional, McCourt, P, additional, Mcgarvey, L, additional, McGinness, J, additional, McGovern, A, additional, McGuinness, H, additional, McInnes, I B, additional, McIvor, K, additional, McIvor, E, additional, McMahon, A, additional, McMahon, M J, additional, McMorrow, L, additional, Mcnally, T, additional, McNarry, M, additional, McQueen, A, additional, McShane, H, additional, Megson, S, additional, Meiring, J, additional, Menzies, D, additional, Michael, A, additional, Milligan, L, additional, Mills, N, additional, Mitchell, J, additional, Mohamed, A, additional, Molyneaux, P L, additional, Monteiro, W, additional, Morley, A, additional, Morrison, L, additional, Morriss, R, additional, Morrow, A, additional, Moss, A, additional, Moss, A J, additional, Moss, P, additional, Mukaetova-Ladinska, E, additional, Munawar, U, additional, Murali, E, additional, Murira, J, additional, Nassa, H, additional, Neill, P, additional, Neubauer, S, additional, Newby, D, additional, Newell, H, additional, Newton Cox, A, additional, Nicholson, T, additional, Nicoll, D, additional, Nolan, C M, additional, Noonan, M J, additional, Novotny, P, additional, Nunag, J, additional, Nyaboko, J, additional, O'Brien, L, additional, Odell, N, additional, Ogg, G, additional, Olaosebikan, O, additional, Oliver, C, additional, Omar, Z, additional, Openshaw, P J M, additional, Rivera-Ortega, P, additional, Osbourne, R, additional, Ostermann, M, additional, Overton, C, additional, Oxton, J, additional, Pacpaco, E, additional, Paddick, S, additional, Papineni, P, additional, Paradowski, K, additional, Pareek, M, additional, Parekh, D, additional, Parfrey, H, additional, Pariante, C, additional, Parker, S, additional, Parkes, M, additional, Parmar, J, additional, Parvin, R, additional, Patale, S, additional, Patel, B, additional, Patel, S, additional, Patel, M, additional, Pathmanathan, B, additional, Pavlides, M, additional, Pearl, J E, additional, Peckham, D, additional, Pendlebury, J, additional, Peng, Y, additional, Pennington, C, additional, Peralta, I, additional, Perkins, E, additional, Peto, T, additional, Petousi, N, additional, Petrie, J, additional, Pfeffer, P, additional, Phipps, J, additional, Pimm, J, additional, Piper Hanley, K, additional, Pius, R, additional, Plein, S, additional, Plekhanova, T, additional, Poinasamy, K, additional, Polgar, O, additional, Poll, L, additional, Porter, J C, additional, Portukhay, S, additional, Powell, N, additional, Price, L, additional, Price, D, additional, Price, A, additional, Price, C, additional, Prickett, A, additional, Quaid, S, additional, Quigley, J, additional, Quint, J, additional, Qureshi, H, additional, Rahman, N, additional, Rahman, M, additional, Ralser, M, additional, Raman, B, additional, Ramos, A, additional, Rangeley, J, additional, Rees, T, additional, Regan, K, additional, Richards, A, additional, Richardson, M, additional, Robertson, E, additional, Rodgers, J, additional, Ross, G, additional, Rossdale, J, additional, Rostron, A, additional, Routen, A, additional, Rowland, A, additional, Rowland, M J, additional, Rowland, J, additional, Rowland-Jones, S L, additional, Roy, K, additional, Rudan, I, additional, Russell, R, additional, Russell, E, additional, Sabit, R, additional, Sage, E K, additional, Samani, N, additional, Samuel, R, additional, Sapey, E, additional, Saralaya, D, additional, Saratzis, A, additional, Sargeant, J, additional, Sass, T, additional, Sattar, N, additional, Saunders, K, additional, Saunders, R, additional, Saxon, W, additional, Sayer, A, additional, Schwaeble, W, additional, Scott, J, additional, Scott, K, additional, Selby, N, additional, Semple, M G, additional, Sereno, M, additional, Shah, K, additional, Shah, A, additional, Shah, P, additional, Sharma, M, additional, Sharpe, M, additional, Sharpe, C, additional, Shaw, V, additional, Sheikh, A, additional, Shevket, K, additional, Shikotra, A, additional, Short, J, additional, Siddiqui, S, additional, Sigfrid, L, additional, Simons, G, additional, Simpson, J, additional, Singapuri, A, additional, Singh, S J, additional, Singh, C, additional, Singh, S, additional, Skeemer, J, additional, Smith, I, additional, Smith, J, additional, Smith, L, additional, Smith, A, additional, Soares, M, additional, Southern, D, additional, Spears, M, additional, Spencer, L G, additional, Speranza, F, additional, Stadon, L, additional, Stanel, S, additional, Steiner, M, additional, Stensel, D, additional, Stern, M, additional, Stewart, I, additional, Stockley, J, additional, Stone, R, additional, Storrie, A, additional, Storton, K, additional, Stringer, E, additional, Subbe, C, additional, Sudlow, C, additional, Suleiman, Z, additional, Summers, C, additional, Summersgill, C, additional, Sutherland, D, additional, Sykes, D L, additional, Sykes, R, additional, Talbot, N, additional, Tan, A L, additional, Taylor, C, additional, Taylor, A, additional, Te, A, additional, Tedd, H, additional, Tee, C J, additional, Tench, H, additional, Terry, S, additional, Thackray-Nocera, S, additional, Thaivalappil, F, additional, Thickett, D, additional, Thomas, D, additional, Thomas, D C, additional, Thomas, A K, additional, Thompson, A A R, additional, Thompson, T, additional, Thornton, T, additional, Thwaites, R S, additional, Tobin, M, additional, Toingson, G F, additional, Tong, C, additional, Toshner, M, additional, Touyz, R, additional, Tripp, K A, additional, Tunnicliffe, E, additional, Turner, E, additional, Turtle, L, additional, Turton, H, additional, Ugwuoke, R, additional, Upthegrove, R, additional, Valabhji, J, additional, Vellore, K, additional, Wade, E, additional, Wain, L V, additional, Wajero, L O, additional, Walder, S, additional, Walker, S, additional, Wall, E, additional, Wallis, T, additional, Walmsley, S, additional, Walsh, S, additional, Walsh, J A, additional, Watson, L, additional, Watson, J, additional, Watson, E, additional, Welch, C, additional, Welch, H, additional, Welsh, B, additional, Wessely, S, additional, West, S, additional, Wheeler, H, additional, Whitehead, V, additional, Whitney, J, additional, Whittaker, S, additional, Whittam, B, additional, Wild, J, additional, Wilkins, M, additional, Wilkinson, D, additional, Williams, N, additional, Williams, B, additional, Williams, J, additional, Williams-Howard, S A, additional, Willicombe, M, additional, Willis, G, additional, Wilson, D, additional, Wilson, I, additional, Window, N, additional, Witham, M, additional, Wolf-Roberts, R, additional, Woodhead, F, additional, Woods, J, additional, Wootton, D, additional, Worsley, J, additional, Wraith, D, additional, Wright, L, additional, Wright, C, additional, Wright, S, additional, Xie, C, additional, Yasmin, S, additional, Yates, T, additional, Yip, K P, additional, Young, B, additional, Young, S, additional, Young, A, additional, Yousuf, A J, additional, Yousuf, A, additional, Zawia, A, additional, Zhao, B, additional, and Zongo, O, additional

Published
2021
Full Text
View/download PDF

42. Additional file 1 of Perceptions of anonymised data use and awareness of the NHS data opt-out amongst patients, carers and healthcare staff

Author

Atkin, C., Crosby, B., Dunn, K., Price, G., Marston, E., Crawford, C., O’Hara, M., Morgan, C., Levermore, M., Gallier, S., Modhwadia, S., Attwood, J., Perks, S., Denniston, A. K., Gkoutos, G., Dormer, R., Rosser, A., Ignatowicz, A., Fanning, H., and Sapey, E.

Subjects
education, geographic locations
Abstract

Additional file 1: Table S1. Questions asked regarding data use. Table S2. Direct quotes from the workshops. Figure S1. Demographics of questionnaire respondents, University Hospitals Birmingham NHS Foundation Trust patients and population of Birmingham. a) Ethnicity; b) age for adults aged 25 years and over. Birmingham data was based on the 2011 census data. Hospital patients were based on all patient episodes from January 2019 to January 2020 (data from PIONEER Hub). There was less representation of Asian/ Asian British ethnicity in the questionnaire than in the Birmingham catchment area (p = 0.004), but no differences in other ethnic groups and no differences in ethnicity groups from UHB patients (all episodes January 2019 – January 2020). There were more people aged 65 – 74 in the questionnaire than the Birmingham catchment area census data, but no other significant differences in age from the Birmingham census data.

Published
2021
Full Text
View/download PDF

43. The effect of short-term exercise prehabilitation on skeletal muscle protein synthesis and atrophy during bed rest in older men

Author

Smeuninx, B, Elhassan, YS, Manolopoulos, KN, Sapey, E, Rushton, AB, Edwards, SJ, Morgan, P, Philp, A, Brook, MS, Gharahdaghi, N, Smith, K, Atherton, PJ, Breen, L, Smeuninx, B, Elhassan, YS, Manolopoulos, KN, Sapey, E, Rushton, AB, Edwards, SJ, Morgan, P, Philp, A, Brook, MS, Gharahdaghi, N, Smith, K, Atherton, PJ, and Breen, L

Abstract

Background: Poor recovery from periods of disuse accelerates age-related muscle loss, predisposing individuals to the development of secondary adverse health outcomes. Exercise prior to disuse (prehabilitation) may prevent muscle deterioration during subsequent unloading. The present study aimed to investigate the effect of short-term resistance exercise training (RET) prehabilitation on muscle morphology and regulatory mechanisms during 5 days of bed rest in older men. Methods: Ten healthy older men aged 65–80 years underwent four bouts of high-volume unilateral leg RET over 7 days prior to 5 days of inpatient bed rest. Physical activity and step-count were monitored over the course of RET prehabilitation and bed rest, whilst dietary intake was recorded throughout. Prior to and following bed rest, quadriceps cross-sectional area (CSA), and hormone/lipid profiles were determined. Serial muscle biopsies and dual-stable isotope tracers were used to determine integrated myofibrillar protein synthesis (iMyoPS) over RET prehabilitation and bed rest phases, and acute postabsorptive and postprandial myofibrillar protein synthesis (aMyoPS) rates at the end of bed rest. Results: During bed rest, daily step-count and light and moderate physical activity time decreased, whilst sedentary time increased when compared with habitual levels (P < 0.001 for all). Dietary protein and fibre intake during bed rest were lower than habitual values (P < 0.01 for both). iMyoPS rates were significantly greater in the exercised leg (EX) compared with the non-exercised control leg (CTL) over prehabilitation (1.76 ± 0.37%/day vs. 1.36 ± 0.18%/day, respectively; P = 0.007). iMyoPS rates decreased similarly in EX and CTL during bed rest (CTL, 1.07 ± 0.22%/day; EX, 1.30 ± 0.38%/day; P = 0.037 and 0.002, respectively). Postprandial aMyoPS rates increased above postabsorptive values in EX only (P = 0.018), with no difference in delta postprandial aMyoPS stimulation between legs. Quadriceps CSA at 40

Published
2021

44. Impact of the UK Lockdown on Early COPD

Author

Donaldson, G.C., primary, Ritchie, A.I., additional, McLean, F., additional, King, B., additional, Yip, K.P., additional, Beech, A.S., additional, Bikov, A., additional, Jenkins, A.R., additional, Deans, A., additional, Bolton, C.E.R., additional, Calverley, P.M., additional, Choudhury, G., additional, McGarvey, L., additional, Sapey, E., additional, Vestbo, J., additional, and Wedzicha, J.A., additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results