1,510 results on '"Sanz Y"'
Search Results
2. Christensenella minuta mitigates behavioral and cardiometabolic hallmarks of social defeat stress
- Author
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Agusti, A., Molina-Mendoza, GV., Tamayo, M., Rossini, V., Cenit, MC., Frances-Cuesta, C., Tolosa-Enguis, V., Gómez Del Pulgar, EM., Flor-Duro, A., and Sanz, Y.
- Published
- 2024
- Full Text
- View/download PDF
3. ANÁLISIS DE LA EFECTIVIDAD DEL PROGRAMA VINCULACIÓN EMOCIONAL CONSCIENTE PARA INCREMENTAR COMPETENCIAS EMOCIONALES DEL PROFESORADO
- Author
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ARTZAMENDI, SAIOA TELLETXEA, primary, UNDABARRENA, ARITZ ANASAGASTI, additional, AIZPURUA, ALAITZ, additional, and SOROA, SANZ Y MARIAN, additional
- Published
- 2022
- Full Text
- View/download PDF
4. Gut microbiome and anti-viral immunity in COVID-19.
- Author
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Rossini, V., Tolosa-Enguis, V., Frances-Cuesta, C., and Sanz, Y.
- Subjects
GUT microbiome ,COVID-19 ,DISEASE management ,IMMUNITY ,SARS-CoV-2 - Abstract
SARS-CoV-2 mainly affects the respiratory system, but the gastrointestinal tract is also a target. Prolonged gut disorders, in COVID-19 patients, were correlated with decreased richness and diversity of the gut microbiota, immune deregulation and delayed viral clearance. Although there are no definitive conclusions, ample evidence would suggest that the gut microbiome composition and function play a role in COVID-19 progression. Microbiome modulation strategies for population stratification and management of COVID-19 infection are under investigation, representing an area of interest in the ongoing pandemic. In this review, we present the existing data related to the interaction between gut microbes and the host's immune response to SARS-CoV-2 and discuss the implications for current disease management and readiness to face future pandemics. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Safety for the environment of a feed additive consisting of diclazuril (Coxiril®) for chickens reared for laying and pheasants (Huvepharma NV)
- Author
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Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Durjava, M, Dusemund, B, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Poiger, T, Teodorovic, I, Vettori, M, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Durjava M., Dusemund B., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Poiger T., Teodorovic I., Vettori M. V., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Durjava, M, Dusemund, B, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Poiger, T, Teodorovic, I, Vettori, M, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Durjava M., Dusemund B., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Poiger T., Teodorovic I., and Vettori M. V.
- Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety for the environment of diclazuril (Coxiril®) as a coccidiostat feed additive for chickens reared for laying and pheasants. In its previous assessments, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not reach a final conclusion on the risk resulting from the use of diclazuril in acid soil from Coxiril®. On the basis of the new data provided, the FEEDAP Panel updates the previous conclusions as follows: no risk is expected for the terrestrial compartment and for sediment when diclazuril is used in chickens reared for laying and to pheasants at the proposed condition of use (in both acidic and non-acidic soils). No concern for groundwater is expected for both acidic and non-acidic soils. Due to the lack of data, no conclusions can be drawn for the aquatic compartment. Diclazuril does not have the potential for bioaccumulation; therefore, a risk of secondary poisoning is unlikely.
- Published
- 2023
6. Safety and efficacy of a feed additive consisting of a zinc(II)–betaine complex for all animal species (Biochem Zusatzstoffe Handels- und Produktionsges. mbH)
- Author
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Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Durjava, M, Kouba, M, Lopez-Alonso, M, Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Poiger, T, Teodorovic, I, Anguita, M, Galobart, J, Holczknecht, O, Innocenti, M, Ortuno, J, Manini, P, Pizzo, F, Radovnikovic, A, Vettori, M, Amaduzzi, A, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Durjava M., Kouba M., Lopez-Alonso M., Puente S. L., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Poiger T., Teodorovic I., Anguita M., Galobart J., Holczknecht O., Innocenti M. L., Ortuno J. C., Manini P., Pizzo F., Radovnikovic A., Vettori M. V., Amaduzzi A., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Durjava, M, Kouba, M, Lopez-Alonso, M, Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Poiger, T, Teodorovic, I, Anguita, M, Galobart, J, Holczknecht, O, Innocenti, M, Ortuno, J, Manini, P, Pizzo, F, Radovnikovic, A, Vettori, M, Amaduzzi, A, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Durjava M., Kouba M., Lopez-Alonso M., Puente S. L., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Poiger T., Teodorovic I., Anguita M., Galobart J., Holczknecht O., Innocenti M. L., Ortuno J. C., Manini P., Pizzo F., Radovnikovic A., Vettori M. V., and Amaduzzi A.
- Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a zinc(II)–betaine complex as nutritional additive for all animal species. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additive is safe for chickens for fattening. This conclusion could be extrapolated to all animal species and categories provided that the maximum authorised levels in the EU for total zinc in feed are not exceeded. The FEEDAP Panel concluded that the use of the zinc(II)–betaine complex in animal nutrition is of no concern for consumer safety provided that the maximum authorised total zinc levels in feed are respected. The additive is considered to be a skin and respiratory sensitiser due to the presence of nickel; it is irritant to the eyes, but not to the skin. The use of the additive in animal nutrition for terrestrial animals and land-based aquaculture at the proposed use levels is considered safe for terrestrial and aquatic ecosystems. The available data do not allow the conclusion to be made on the safety of the additive for the marine sediment when it is used in sea cages. Based on the deposition of zinc in edible tissues/organs in chickens for fattening, the FEEDAP Panel concluded that the additive is a source of bioavailable zinc, comparable to the standard inorganic zinc source, and therefore, the additive is efficacious in meeting the birds zinc requirements. This conclusion can be extrapolated to all animal species and categories.
- Published
- 2023
7. Safety and efficacy of a feed additive consisting of copper(II)-betaine complex for all animal species (Biochem Zusatzstoffe Handels- und Produktionsges. mbH)
- Author
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Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Durjava, M, Kouba, M, López-Alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Poiger, T, Teodorović, I, Amaduzzi, A, Anguita, M, Galobart, J, Innocenti, M, Manini, P, Ortuño, J, Pizzo, F, Tarrés-Call, J, Vettori, M, Radovnikovic, A, Bampidis V., Azimonti G., Bastos M. d. L., Christensen H., Dusemund B., Durjava M., Kouba M., López-Alonso M., López Puente S., Marcon F., Mayo B., Pechová A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Poiger T., Teodorović I., Amaduzzi A., Anguita M., Galobart J., Innocenti M. L., Manini P., Ortuño J., Pizzo F., Tarrés-Call J., Vettori M. V., Radovnikovic A., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Durjava, M, Kouba, M, López-Alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Poiger, T, Teodorović, I, Amaduzzi, A, Anguita, M, Galobart, J, Innocenti, M, Manini, P, Ortuño, J, Pizzo, F, Tarrés-Call, J, Vettori, M, Radovnikovic, A, Bampidis V., Azimonti G., Bastos M. d. L., Christensen H., Dusemund B., Durjava M., Kouba M., López-Alonso M., López Puente S., Marcon F., Mayo B., Pechová A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Poiger T., Teodorović I., Amaduzzi A., Anguita M., Galobart J., Innocenti M. L., Manini P., Ortuño J., Pizzo F., Tarrés-Call J., Vettori M. V., and Radovnikovic A.
- Abstract
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP Panel) was asked to deliver a scientific opinion on the safety and efficacy of a copper(II)-betaine complex as nutritional feed additive for all animal species. Based on the results of a tolerance study carried out in chicken, the FEEDAP Panel concluded that the additive is safe for chickens for fattening when used up to the current maximum authorised levels of copper in feed; this conclusion was extrapolated to all animal species and categories at the respective maximum copper levels in complete feed authorised in the European Union. The FEEDAP Panel concluded that the use of the copper(II)-betaine complex in animal nutrition at the maximum copper levels authorised for the animal species poses no concern to the safety of consumers. Regarding the safety for the environment, the use of the additive in feed for terrestrial animals and land-based aquaculture is considered safe under proposed conditions of use. The data available do not allow the conclusion to be made on the safety of the additive for marine sediment when it is used in sea cages. The additive is not a skin irritant, but it is an irritant to the eyes. Due to the traces of nickel, the additive is considered to be a respiratory and skin sensitiser. The Panel could not conclude on the efficacy of the product.
- Published
- 2023
8. Herbal and Dietary Supplement-Induced Liver Injuries in the Spanish DILI Registry
- Author
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Andrade, RJ, Lucena, MI, Stephens, C, García-Cortés, M, Robles-Díaz, M, Medina-Cáliz, I, Sanabria, J, García-Muñoz, B, Alcántara, R, Moreno, I, Gonzalez-Jimenez, A, Ortega-Alonso, A, Sanjuán-Jiménez, R, Quirós, M, Martín-Reyes, F, Papineau, A, Jiménez-Pérez, M, González-Grande, R, Fernández, MC, Peláez, G, Casado, M, González-Sánchez, M, Romero-Gómez, M, Calle-Sanz, R, Millán-Domínguez, R, Fombuena, B, Gallego, R, Rojas, L, Rojas, A, Ampuero, J, del Campo, JA, Gil Gómez, A, Vilar, E, Castiella, A, Zapata, EM, Zubiaurre, L, Navarro, JM, Méndez-Sánchez, IM, Chaves, A, Soriano, G, Guarner, C, Román, EM, Hallal, H, García-Oltra, E, Titos-Arcos, JC, Pérez-Martínez, A, Sánchez-Cobarro, C, Egea-Caparrós, JM, Arenas, J, Gomez-Osua, MI, Gómez-García, A, Esandi, FJ, Blanco, S, Martínez-Odriozola, P, Otazua, P, Salmerón, J, Gila, A, Quiles, R, González, JM, Lorenzo, S, Prieto, M, Conde, I, Amiel, Berenguer, M, García-Eliz, M, Primo, J, Molés, JR, Garayoa, A, Carrascosa, M, Gómez- Domínguez, E, Montané, E, Arellano, AL, Barriocanal, AM, Sanz, Y, Morillas, RM, Sala, M, Masnou, H, Farré, M, Bruguera, M, Gines, P, Lens, S, García, JC, Aldea-Perona, A, Hernández-Guerra, M, Moreno-San Fiel, M, Boada-Fernández del Campo, C, Tejedor, M, González-Ferrer, R, Fernández, C, Fernández-Gil, M, Montero, JL, de la Mata, M, Fuentes-Olmo, J, Fernández-Bonilla, EM, González-Gallego, J, Jorquera, F, Moreno, JM, Martínez-Rodenas, P, Garrido, M, Rendón, P, Vergara, M, Sánchez Delgado, J, García Samaniego, J, Madejón, A, Cabriada, JL, Crespo, J, Giráldez Gallego, A, Cuaresma, M, Ruíz, R, Medina-Caliz, Inmaculada, Garcia-Cortes, Miren, Gonzalez-Jimenez, Andres, Cabello, Maria R., Robles-Diaz, Mercedes, Sanabria-Cabrera, Judith, Sanjuan-Jimenez, Rocio, Ortega-Alonso, Aida, García-Muñoz, Beatriz, Moreno, Inmaculada, Jimenez-Perez, Miguel, Fernandez, M Carmen, Ginés, Pere, Prieto, Martin, Conde, Isabel, Hallal, Hacibe, Soriano, German, Roman, Eva, Castiella, Agustin, Blanco-Reina, Encarnacion, Montes, Maria R., Quiros-Cano, Marta, Martin-Reyes, Flores, Lucena, M. Isabel, and Andrade, Raul J.
- Published
- 2018
- Full Text
- View/download PDF
9. Stress Intensity Factor and propagation of an open sickle shaped crack in a shaft under bending
- Author
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Rubio, P., Sanz, Y., Rubio, L., and Muñoz-Abella, B.
- Published
- 2018
- Full Text
- View/download PDF
10. Factors affecting the incidence of contrast-induced nephropathy in patients undergoing computed tomography
- Author
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Heras Benito, M., Garrido Blázquez, M., Gómez Sanz, Y., Bernardez Mardomingo, M., Ruiz Cacho, J., Rodríguez Recio, F.J., and Fernández-Reyes Luis, M.J.
- Published
- 2018
- Full Text
- View/download PDF
11. Incidencia de nefropatía por contraste en pacientes sometidos a tomografía computarizada: ¿qué factores la condicionan?
- Author
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Heras Benito, M., Garrido Blázquez, M., Gómez Sanz, Y., Bernardez Mardomingo, M., Ruiz Cacho, J., Rodríguez Recio, F.J., and Fernández-Reyes Luis, M.J.
- Published
- 2018
- Full Text
- View/download PDF
12. Bifidobacterium CECT 7765 modulates early stress-induced immune, neuroendocrine and behavioral alterations in mice
- Author
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Moya-Pérez, A., Perez-Villalba, A., Benítez-Páez, A., Campillo, I., and Sanz, Y.
- Published
- 2017
- Full Text
- View/download PDF
13. How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging.
- Author
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Tamayo, M., Olivares, M., Ruas-Madiedo, P., Margolles, A., Espín, J.C., Medina, I., Moreno-Arribas, M.V., Canals, S., Mirasso, C.R., Ortín, S., Beltrán-Sanchez, H., Palloni, A., Tomás-Barberán, F.A., and Sanz, Y.
- Published
- 2024
- Full Text
- View/download PDF
14. Safety and efficacy of a feed additive consisting of copper(II)-betaine complex for all animal species (Biochem Zusatzstoffe Handels- und Produktionsges. mbH)
- Author
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Bampidis V., Azimonti G., Bastos M. d. L., Christensen H., Dusemund B., Durjava M., Kouba M., López-Alonso M., López Puente S., Marcon F., Mayo B., Pechová A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Poiger T., Teodorović I., Amaduzzi A., Anguita M., Galobart J., Innocenti M. L., Manini P., Ortuño J., Pizzo F., Tarrés-Call J., Vettori M. V., Radovnikovic A., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Durjava, M, Kouba, M, López-Alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Poiger, T, Teodorović, I, Amaduzzi, A, Anguita, M, Galobart, J, Innocenti, M, Manini, P, Ortuño, J, Pizzo, F, Tarrés-Call, J, Vettori, M, and Radovnikovic, A
- Subjects
safety ,copper ,copper complex of betaine ,efficacy ,nutritional additive ,compounds of trace element - Abstract
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP Panel) was asked to deliver a scientific opinion on the safety and efficacy of a copper(II)-betaine complex as nutritional feed additive for all animal species. Based on the results of a tolerance study carried out in chicken, the FEEDAP Panel concluded that the additive is safe for chickens for fattening when used up to the current maximum authorised levels of copper in feed; this conclusion was extrapolated to all animal species and categories at the respective maximum copper levels in complete feed authorised in the European Union. The FEEDAP Panel concluded that the use of the copper(II)-betaine complex in animal nutrition at the maximum copper levels authorised for the animal species poses no concern to the safety of consumers. Regarding the safety for the environment, the use of the additive in feed for terrestrial animals and land-based aquaculture is considered safe under proposed conditions of use. The data available do not allow the conclusion to be made on the safety of the additive for marine sediment when it is used in sea cages. The additive is not a skin irritant, but it is an irritant to the eyes. Due to the traces of nickel, the additive is considered to be a respiratory and skin sensitiser. The Panel could not conclude on the efficacy of the product.
- Published
- 2023
15. Safety and efficacy of a feed additive consisting of halofuginone hydrobromide (STENOROL®) for chickens for fattening and turkeys for fattening/reared for breeding (Huvepharma N.V.)
- Author
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Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Durjava M., Dusemund B., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Gropp J., Rychen G., Finizio A., Poiger T., Teodorovic I., Aquilina G., Bories G., Brantom P., Holczknecht O., Navarro-Villa A., Rossi B., Vettori M. V., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Durjava, M, Dusemund, B, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Gropp, J, Rychen, G, Finizio, A, Poiger, T, Teodorovic, I, Aquilina, G, Bories, G, Brantom, P, Holczknecht, O, Navarro-Villa, A, Rossi, B, and Vettori, M
- Subjects
safety ,halofuginone hydrobromide ,efficacy ,turkeys reared for breeding ,chickens for fattening ,turkeys for fattening ,coccidiostat - Abstract
Following a request from the European Commission, EFSA was asked to deliver a new scientific opinion on the coccidiostat halofuginone hydrobromide (STENOROL®) when used as a feed additive for chickens for fattening and turkeys for fattening/reared for breeding. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concludes that the safety for turkeys for fattening established in its previous opinion can be extended to turkeys for breeding up to 12 weeks of age. Based on the new data provided on the safety for consumer, environment and efficacy, the Panel updates its previous conclusions as follows: halofuginone hydrobromide is not genotoxic. Applying an uncertainty factor of 100 to the lowest no observed adverse effect level (NOAEL) of 0.03 mg/kg body weight (bw) per day, an acceptable daily intake (ADI) of 0.3 μg halofuginone/kg bw is established. The chronic exposure of consumers to residues of halofuginone would amount to 6–19% of the ADI after 3 days of withdrawal. Therefore, the Panel considers that the additive is safe for the consumer of tissues obtained from chickens for fattening and turkeys for fattening fed the additive at a maximum level of 3 mg/kg complete feed at a 3-day withdrawal time. For control purposes, the Panel recommends the setting of the following maximum residue limits (MRLs): liver, 50 μg/kg; kidney, 40 μg/kg; muscle, 3 μg/kg; skin/fat, 10 μg/kg wet tissue. Based on an updated environmental risk assessment, no concern for groundwater is expected. Halofuginone is unlikely to bioaccumulate and the risk of secondary poisoning is not likely to occur. No safety concerns are expected for terrestrial and aquatic environments. The additive has the potential to control coccidiosis in chickens for fattening and turkeys for fattening/reared for breeding up to 12 weeks of age at a minimum level of 2 mg/kg complete feed.
- Published
- 2023
16. Safety and efficacy of a feed additive consisting of a zinc(II)–betaine complex for all animal species (Biochem Zusatzstoffe Handels- und Produktionsges. mbH)
- Author
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Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Durjava M., Kouba M., Lopez-Alonso M., Puente S. L., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Poiger T., Teodorovic I., Anguita M., Galobart J., Holczknecht O., Innocenti M. L., Ortuno J. C., Manini P., Pizzo F., Radovnikovic A., Vettori M. V., Amaduzzi A., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Durjava, M, Kouba, M, Lopez-Alonso, M, Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Poiger, T, Teodorovic, I, Anguita, M, Galobart, J, Holczknecht, O, Innocenti, M, Ortuno, J, Manini, P, Pizzo, F, Radovnikovic, A, Vettori, M, and Amaduzzi, A
- Subjects
safety ,zinc(II)–betaine complex ,efficacy ,nutritional additive ,zinc sulfate and betaine ,compounds of trace element - Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a zinc(II)–betaine complex as nutritional additive for all animal species. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additive is safe for chickens for fattening. This conclusion could be extrapolated to all animal species and categories provided that the maximum authorised levels in the EU for total zinc in feed are not exceeded. The FEEDAP Panel concluded that the use of the zinc(II)–betaine complex in animal nutrition is of no concern for consumer safety provided that the maximum authorised total zinc levels in feed are respected. The additive is considered to be a skin and respiratory sensitiser due to the presence of nickel; it is irritant to the eyes, but not to the skin. The use of the additive in animal nutrition for terrestrial animals and land-based aquaculture at the proposed use levels is considered safe for terrestrial and aquatic ecosystems. The available data do not allow the conclusion to be made on the safety of the additive for the marine sediment when it is used in sea cages. Based on the deposition of zinc in edible tissues/organs in chickens for fattening, the FEEDAP Panel concluded that the additive is a source of bioavailable zinc, comparable to the standard inorganic zinc source, and therefore, the additive is efficacious in meeting the birds zinc requirements. This conclusion can be extrapolated to all animal species and categories.
- Published
- 2023
17. Safety of a feed additive consisting of semduramicin sodium (Aviax 5%) for chickens for fattening (Phibro Animal Health s.a.)
- Author
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Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Fasmon Durjava, M, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Bories, G, Cocconcelli, P, Finizio, A, Gropp, J, Rychen, G, Teodorovic, I, Brozzi, R, Holczknecht, O, Pettenati, E, Revez, J, Vettori, M, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Fasmon Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Bories G., Cocconcelli P. S., Finizio A., Gropp J., Rychen G., Teodorovic I., Brozzi R., Holczknecht O., Pettenati E., Revez J., Vettori M. V., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Fasmon Durjava, M, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Bories, G, Cocconcelli, P, Finizio, A, Gropp, J, Rychen, G, Teodorovic, I, Brozzi, R, Holczknecht, O, Pettenati, E, Revez, J, Vettori, M, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Fasmon Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Bories G., Cocconcelli P. S., Finizio A., Gropp J., Rychen G., Teodorovic I., Brozzi R., Holczknecht O., Pettenati E., Revez J., and Vettori M. V.
- Abstract
Following a request from the European Commission, the Panel on Additives and Products or substances used in Animal Feed (FEEDAP Panel) was asked to deliver a scientific opinion on the safety of the coccidiostat Aviax 5% (semduramicin sodium) when used in feed for chickens for fattening. In a previous assessment, the FEEDAP Panel could not conclude on the taxonomical identification of the production strain at species level and on the absence of genetic determinants for antimicrobial resistance. In addition, the Panel could not conclude on the safety for the target animals and could not set maximum residue limits to protect consumers. Regarding the safety for the environment, although the use of the additive was considered safe for the terrestrial compartment, a risk for the aquatic compartment and for groundwater pollution could not be excluded. Based on the new data provided, the FEEDAP Panel concludes that there are no safety concerns for the target animals, consumer, user and environment regarding the production strain of semduramicin sodium. Based on the results in the tolerance trial, the FEEDAP Panel concludes that the additive is safe for chickens for fattening up to the maximum recommended level (25 mg/kg complete feed), but no margin of safety can be established. The use of semduramicin sodium at a maximum level of 25 mg/kg complete feed for chickens for fattening is safe for consumers with no withdrawal time. Based on the new data provided and the current requirements for environmental risk assessment, the use of semduramicin sodium from Aviax 5% in feed for chickens for fattening up to 25 mg/kg complete feed does not pose a risk for groundwater nor for aquatic and sediment compartments, while a risk for the terrestrial compartment cannot be excluded. The bioaccumulation and the risk for secondary poisoning are considered to be low.
- Published
- 2022
18. Gut microbiome and anti-viral immunity in COVID-19
- Author
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Rossini, V., primary, Tolosa-Enguis, V., additional, Frances-Cuesta, C., additional, and Sanz, Y., additional
- Published
- 2022
- Full Text
- View/download PDF
19. Impaired responses to gliadin and gut microbes of immune cells from mice with altered stress-related behavior and premature immune senescence
- Author
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De Palma, G., Vida, C., Santacruz, A., De Castro, N.M., De la Fuente, M., and Sanz, Y.
- Published
- 2014
- Full Text
- View/download PDF
20. Safety and efficacy of a feed additive consisting of endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase produced with Talaromyces versatilis IMI 378536 and DSM 26702 (ROVABIO® ADVANCE) for weaned piglets and pigs for fattening (ADISSEO France S.A.S)
- Author
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Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Fasmon Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Dierick N., Martelli G., Galobart J., Ortuno J., Anguita M., Bampidis V., Azimonti G., Bastos M.D.L., Christensen H., Dusemund B., Fasmon Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R.E., Woutersen R., Dierick N., Martelli G., Galobart J., Ortuno J., and Anguita M.
- Subjects
safety ,xylanase ,T. versatili ,glucanase ,Veterinary (miscellaneous) ,efficacy ,Animal Science and Zoology ,Parasitology ,Plant Science ,Microbiology ,Food Science ,digestibility enhancer ,zootechnical additives - Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of ROVABIO® ADVANCE (liquid and solid) which contains endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase. The enzymes present in the additive are produced by two strains of Talaromyces versatilis, one of them genetically modified. The additive is intended to be used as a feed additive for weaned piglets and pigs for fattening. Viable cells of the production strains and DNA of the genetically modified strain were not detected in the fermentation product used to formulate the additive. Based on the results of a tolerance trial in weaned piglets, the FEEDAP Panel concluded that ROVABIO® ADVANCE is safe for weaned piglets under the recommended conditions of use. This conclusion was extended to pigs for fattening. Based on the outcome of the toxicological studies performed, the Panel concluded that the additive is of no concern regarding consumer safety. ROVABIO® ADVANCE is not irritant to the skin or eyes but it is a skin and respiratory sensitiser. No risks to the environment are expected from the use of the additive in animal nutrition. Owing to the lack of sufficient data, the FEEDAP Panel could not conclude on the efficacy of ROVABIO® ADVANCE.
- Published
- 2022
21. Safety and efficacy of a feed additive consisting of Bifidobacterium longum CNCM I-5642 (PP102I) for cats and dogs (Nestlé Enterprises S.A.)
- Author
-
Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Fasmon Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Martelli G., Raj M., Anguita M., Brozzi R., Galobart J., Pettenati E., Revez J., Tarres-Call J., Ortuno J., Bampidis V., Azimonti G., Bastos M.D.L., Christensen H., Dusemund B., Fasmon Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R.E., Woutersen R., Martelli G., Raj M., Anguita M., Brozzi R., Galobart J., Pettenati E., Revez J., Tarres-Call J., and Ortuno J.
- Subjects
Bifidobacterium longum CNCM I-5642 ,Veterinary (miscellaneous) ,dog ,PP102I ,cat ,physiological condition stabiliser ,Animal Science and Zoology ,Parasitology ,Plant Science ,Microbiology ,Food Science ,QPS ,zootechnical additives - Abstract
Following a request from the European Commission, the Panelon Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Bifidobacterium longum CNCM I-5642 (PP102I) when used as a feed additive for cats and dogs. The product under assessment consists of viable cells of a strain of B. longum, a species considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The strain was unambiguously identified as B. longum and was shown not to harbour antimicrobial resistance determinants for antibiotics of human and veterinary importance, thus meeting the QPS requirements. Following the QPS approach to safety assessment and since no concerns are expected from maltodextrin, the other component of the additive, PP102I was considered safe for the target species and the environment. Owing to the lack of data, no conclusions could be drawn on the skin/eye irritancy potential of PP102I. However, it should be considered a skin and respiratory sensitiser. The Panelwas not in the position to conclude on the efficacy of PP102I for the target species.
- Published
- 2022
22. Efficacy of a feed additive consisting of endo-1,4-beta-xylanase produced by Trichoderma citrinoviride (IMI SD 135) (HOSTAZYM® X) for sows in order to have benefits in piglets (Huvepharma NV)
- Author
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Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Durjava M. F., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Dierick N. A., Martelli G., Galobart J., Anguita M., Bampidis V., Azimonti G., Bastos M.D.L., Christensen H., Dusemund B., Durjava M.F., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R.E., Woutersen R., Dierick N.A., Martelli G., Galobart J., and Anguita M.
- Subjects
xylanase ,Veterinary (miscellaneous) ,sows ,efficacy ,Plant Science ,Microbiology ,zootechnical additives ,sow ,Animal Science and Zoology ,Parasitology ,digestibility enhancers ,Food Science ,digestibility enhancer - Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of HOSTAZYM® X as a feed additive for sows in order to have benefits in piglets. This additive consists of endo-1,4-β-xylanase produced by a non-genetically modified strain of Trichoderma citroviride. The additive is to be used in sows at 1,500 EPU/kg feed. In a previous opinion, the FEEDAP Panel could not conclude on the efficacy of the additive when added to feed for sows in order to have benefits in piglets. The applicant provided new efficacy data to complete the assessment of the efficacy of the additive. Based on the previously assessed data and the newly submitted one, the Panel could not conclude on the efficacy of the additive.
- Published
- 2022
23. Safety for the environment of a feed additive consisting of nicarbazin (Coxar®) for use in turkeys for fattening (Huvepharma N.V.)
- Author
-
Bampidis, V, Bastos, M, Christensen, H, Dusemund, B, Fasmon Durjava, M, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Focks, A, Teodorovic, I, Vettori, M, Azimonti, G, Bampidis V., Bastos M. D. L., Christensen H., Dusemund B., Fasmon Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Focks A., Teodorovic I., Vettori M. V., Azimonti G., Bampidis, V, Bastos, M, Christensen, H, Dusemund, B, Fasmon Durjava, M, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Focks, A, Teodorovic, I, Vettori, M, Azimonti, G, Bampidis V., Bastos M. D. L., Christensen H., Dusemund B., Fasmon Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Focks A., Teodorovic I., Vettori M. V., and Azimonti G.
- Abstract
Following a request from the European Commission, the Panel on Additives and Products or substances used in Animal Feed (FEEDAP Panel) was asked to deliver a scientific opinion on the safety for the environment of the coccidiostat Coxar® (nicarbazin) when used in feed for turkeys for fattening. In previous assessments, the FEEDAP Panel could not conclude on the safety of Coxar® for the environment due to concerns on 4,40-dinitrocarbanilide (DNC, one of the moieties of nicarbazin). On the basis of the new data provided, the FEEDAP Panel updates its previous conclusions on the safety of Coxar® for the environment as follows: The use of nicarbazin from Coxar® in complete feed for turkeys does not pose a risk for the terrestrial and aquatic compartment and in sediment. No concern for groundwater is expected. The bioaccumulation potential of nicarbazin in the environment is low.
- Published
- 2021
24. From Bacterial Genomics to Human Health
- Author
-
Benítez-Páez, A., primary and Sanz, Y., additional
- Published
- 2017
- Full Text
- View/download PDF
25. List of Contributors
- Author
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Abriouel, H., primary, Aguilera, Y., additional, Amigo, L., additional, Beena, D.J., additional, Benítez-Páez, A., additional, Benítez, V., additional, Benomar, N., additional, Bou, R., additional, Cerezo, A.B., additional, Chung, S.H., additional, Ciesarová, Z., additional, Coda, R., additional, Cofrades, S., additional, Coton, M., additional, Curiel, J.A., additional, Daniel, N., additional, De Freitas, V., additional, de las Rivas, B., additional, Diana, M., additional, Escalante, A., additional, Esteban-Torres, M., additional, Fernandes, I., additional, Fernandez, M.A., additional, Figueroa, L.M., additional, Frias, J., additional, Gálvez, A., additional, Garcia-Parrilla, M.C., additional, Gobbetti, M., additional, Gómez-Guillén, M.C., additional, González-SanJosé, M.L., additional, Gürsoy, O., additional, Gutiérrez-Uribe, J.A., additional, Hernández-Ledesma, B., additional, Ismail, B., additional, Jeong, J.-K., additional, Jiménez-Colmenero, F., additional, Karovičová, J., additional, Kesenkaş, H., additional, Kim, D.-H., additional, Kim, H.-Y., additional, Kim, M., additional, Knapp, C.W., additional, Kohajdová, Z., additional, Landete, J.M., additional, Le Barz, M., additional, López de Felipe, F., additional, López-Caballero, M.E., additional, López-Expósito, I., additional, Magala, M., additional, Mani, V., additional, Marette, A., additional, Martín-Cabrejas, M.A., additional, Martín-del-Campo, S.T., additional, Martínez-Álvarez, O., additional, Martinez-Villaluenga, C., additional, Martín, J.F., additional, Mas, A., additional, Mateus, N., additional, Mikušová, L., additional, Ming, L.C., additional, Miralles, B., additional, Montero, P., additional, Muñoz, R., additional, Nampoothiri, K.M., additional, Özbaş, H., additional, Park, K.-Y., additional, Patel, S., additional, Peñas, E., additional, Peres, C., additional, Peres, C.M., additional, Pérez-Gregorio, R., additional, Picard-Deland, É., additional, Quílez, J., additional, Reiter, R.J., additional, Reverón, I., additional, Rizzello, C.G., additional, Rodríguez, H., additional, Rodríguez, P.M., additional, Ryan, E.P., additional, Santamaría, L., additional, Sanz, Y., additional, Schmid, A., additional, Shukla, S., additional, Simon Sarkadi, L., additional, Soares, S., additional, Surma, M., additional, Torija, M.J., additional, Troncoso, A.M., additional, Valls-Bellés, V., additional, Vasanthakumari, D.S., additional, Walther, B., additional, Wilburn, J.R., additional, Xavier Malcata, F., additional, Zielińska, D., additional, and Zieliński, H., additional
- Published
- 2017
- Full Text
- View/download PDF
26. Safety and efficacy of a feed additive consisting of Sepiolitic clay for all animal species (Mineria y Tecnologia de Arcillas SA - MYTA)
- Author
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Azimonti, G., Bampidis, V., Bastos, M., Christensen, H., Dusemund, B., Kouba, M., Durjava, M., Lopez-Alonso, M., Puente, S., Marcon, F., Mayo, B., Pechova, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R., Woutersen, R., Aquilina, G., Bories, G., Tosti, L., Anguita, M., Galobart, J., Holczknecht, O., Casanova, J., Innocenti, M., Manini, P., and Pizzo, F.
- Subjects
safety ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,Veterinary (miscellaneous) ,anticaking agent ,efficacy ,Plant Science ,Microbiology ,all animal species ,Settore MED/44 - Medicina del Lavoro ,Animal Science and Zoology ,Parasitology ,Sepiolitic clay ,binder ,Food Science - Published
- 2022
27. Safety for the environment of sorbitan monolaurate as a feed additive for all animal species
- Author
-
Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kos Durjava, M, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Bories, G, Finizio, A, Focks, A, Teodorovic, I, Manini, P, Tarres-Call, J, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kos Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Bories G., Finizio A., Focks A., Teodorovic I., Manini P., Tarres-Call J., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kos Durjava, M, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Bories, G, Finizio, A, Focks, A, Teodorovic, I, Manini, P, Tarres-Call, J, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kos Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Bories G., Finizio A., Focks A., Teodorovic I., Manini P., and Tarres-Call J.
- Abstract
The additive sorbitan monolaurate consists of sorbitol (and its anhydrides) esterified with fatty acids derived from coconut oil. It is currently authorised in the European Union and it is intended to be used as a technological additive (functional group of emulsifiers), in feedingstuffs for all animal species, at a maximum concentration of 85 mg/kg complete feed. In 2019, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) issued an opinion on the safety and efficacy of sorbitan monolaurate. Owing the lack of data, the FEEDAP Panel could not conclude on the safety of the additive for the environment. The applicant submitted new data (fate and degradation as well as ecotoxicity data) that were evaluated in the present opinion. The absorption, distribution, metabolism and excretion of structurally related compounds (sorbitan monostearate and sorbitan trioleate) indicate that the additive is expected to be partially metabolised. In addition, sorbitan monolaurate and some related compounds are readily biodegradable. The limited available data on the effects of sorbitan monolaurate in marine crustaceans and in marine sediment indicate that the ecotoxicity of the additive is low, in consistency with the very low acute toxicity of sorbitan esters. Overall, the FEEDAP Panel concludes that a risk of sorbitan monolaurate to terrestrial and aquatic environment is unlikely. Therefore, no safety concerns for the environment are expected from the use of the additive under assessment according to the established conditions of use.
- Published
- 2020
28. Safety and efficacy of nimicoat® (carvacrol) as a zootechnical additive for weaned piglets
- Author
-
Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Durjava, M, Kouba, M, opez-Alonso, M, Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Focks, A, Teodorovic, I, Gropp, J, Mantovani, A, Lopez-Galvez, G, Bampidis V., Azimonti G., Bastos M. L., Christensen H., Dusemund B., Durjava M. K., Kouba M., opez-Alonso M. L., Puente S. L., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Focks A., Teodorovic I., Gropp J., Mantovani A., Lopez-Galvez G., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Durjava, M, Kouba, M, opez-Alonso, M, Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Focks, A, Teodorovic, I, Gropp, J, Mantovani, A, Lopez-Galvez, G, Bampidis V., Azimonti G., Bastos M. L., Christensen H., Dusemund B., Durjava M. K., Kouba M., opez-Alonso M. L., Puente S. L., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Focks A., Teodorovic I., Gropp J., Mantovani A., and Lopez-Galvez G.
- Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy Nimicoat® (carvacrol), as a zootechnical additive for weaned piglets. The additive is composed by carvacrol (≥ 40 %) as an active substance encapsulated with high-melting lipids. Nimicoat® is intended to be used in feed for weaned piglets at a minimum recommended dose of 250 mg/kg complete feed and at a maximum recommended dose of 1,000 mg/kg complete feed corresponding to a minimum and maximum of 100 and 400 mg carvacrol/kg complete feed, respectively. Based on a tolerance study, the FEEDAP Panel concluded that the use of Nimicoat® in feed for weaned piglet at the maximum recommended dose of 1,000 mg/kg feed is safe for the target animal; however, a precise figure for the margin of safety cannot be defined. Nimicoat® used in feed for weaned piglets at the maximum recommended concentration does not pose a safety concern for consumers. The additive is corrosive to eyes, skin and the respiratory mucosae. Concerning safety for the environment a Phase II was required; taking into consideration the data provided, the FEEDAP Panel concluded that the additive does not pose any risk to the terrestrial and aquatic compartments and that bioaccumulation potential for carvacrol is low and risk for secondary poisoning for worm/fish eating birds and mammals is not likely to occur. Only one study positively supporting efficacy of the additive was available therefore, the FEEDAP Panel is not in a position to conclude on the efficacy of Nimicoat®.
- Published
- 2020
29. Safety and efficacy of STABILFLOR® as a zootechnical feed additive for pigs for fattening
- Author
-
Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kos Durjava, M, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Focks, A, Gropp, J, Mantovani, A, Teodorovic, I, Lopez-Galvez, G, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kos Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Focks A., Gropp J., Mantovani A., Teodorovic I., Lopez-Galvez G., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kos Durjava, M, Kouba, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Focks, A, Gropp, J, Mantovani, A, Teodorovic, I, Lopez-Galvez, G, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kos Durjava M., Kouba M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Focks A., Gropp J., Mantovani A., Teodorovic I., and Lopez-Galvez G.
- Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of STABILFLOR® (zinc ethylenediaminetetraacetic acid (Zn-EDTA) and copper diammonium EDTA (Cu-EDTA) dried on chicory pulp and supplemented with zinc oxide and copper oxide), as a zootechnical additive for pigs. STABILFLOR® is intended to be used in feed for pigs for fattening at a minimum and maximum levels of 500 and 1,000 mg/kg complete feed, respectively. The Panel could not conclude on the safety of STABILFLOR® for pigs for fattening owing to the lack of adequate data. At the proposed used levels in feed the additive may exert antimicrobial activity in the gut microbiota. The use of the additive resulted neither in residues of Zn-EDTA, Cu-EDTA or EDTA nor on an increase in total zinc and copper deposition in edible tissues; Zn-EDTA and Cu-EDTA had not a genotoxic potential; the Panel concluded that STABILFLOR® at 1,000 mg/kg complete feed for pigs does not pose any concern to the safety of consumers. The handling of STABILFLOR® will lead to a copper exposure of the users that poses a risk by inhalation; the additive is not a skin irritant or a skin sensitiser but is a severe eye irritant. Regarding environmental safety, no concern was expected for the terrestrial compartment. A risk for groundwater was highlighted for Zn-EDTA. Due to the absence of data, the risk for the aquatic compartment could not be assessed. Only one efficacy study showed positive effects of STABILFLOR® in pigs for fattening at 1,000 mg/kg complete feed; a conclusion on the efficacy of STABILFLOR® could not be drawn. The minimum use level of 500 mg STABILFLOR®/kg complete feed was not tested.
- Published
- 2020
30. Safety of lignosulphonate for all animal species
- Author
-
Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kouba, M, Kos Durjava, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Aquilina, G, Bories, G, Gropp, J, Nebbia, C, Finizio, A, Focks, A, Teodorovic, I, Innocenti, M, Tarres-Call, J, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kouba M., Kos Durjava M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Aquilina G., Bories G., Gropp J., Nebbia C., Finizio A., Focks A., Teodorovic I., Innocenti M. L., Tarres-Call J., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kouba, M, Kos Durjava, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Aquilina, G, Bories, G, Gropp, J, Nebbia, C, Finizio, A, Focks, A, Teodorovic, I, Innocenti, M, Tarres-Call, J, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kouba M., Kos Durjava M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Aquilina G., Bories G., Gropp J., Nebbia C., Finizio A., Focks A., Teodorovic I., Innocenti M. L., and Tarres-Call J.
- Abstract
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of lignosulphonate, when used as a technological additive, functional group: binders. In a previous opinion, the FEEDAP Panel could not conclude on the safety of the additive for target species and for the environment. The applicant provided additional information that was assessed in the current opinion. As regards the safety for the target species, the maximum recommended content of lignosulphonate of 10,000 mg/kg complete feed is considered safe in weaned piglet. A safe concentration of lignosulphonate in feed for salmonids and dairy cows could not be identified. The FEEDAP Panel reiterates also its previous conclusions that ‘10,000 mg lignosulphonate/kg complete feed is safe for chickens for fattening, laying hens and cattle for fattening but a margin of safety cannot be identified. Therefore, this conclusion cannot be extended to all animal species/categories’. Considering the absence of adverse effects confirmed by all the ecotoxicity studies up to very high concentrations, no concerns for the environment are expected from the use of this additive in animal nutrition according the conditions of use. Lignosulphonate is efficacious as pellet binder.
- Published
- 2020
31. Safety and efficacy of a feed additive consisting of l-methionine produced by the combined activities of Corynebacterium glutamicum KCCM 80245 and Escherichia coli KCCM 80246 for all animal species (CJ Europe GmbH)
- Author
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Bampidis, V., Azimonti, G., Bastos, M.D.L., Christensen, H., Dusemund, B., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R.E., Woutersen, R., Anguita, M., Galobart, J., Pettenati, E., and Tarrés-Call, J.
- Subjects
Corynebacterium glutamicum KCCM 80245 ,Escherichia coli KCCM 80246 ,amino acids ,efficacy ,methionine ,nutritional additives ,safety ,their salts and analogues ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,Veterinary (miscellaneous) ,Plant Science ,Microbiology ,Animal Science and Zoology ,Parasitology ,Food Science - Abstract
Following a request from the European Commission, the FEEDAP Panel was asked to deliver a scientific opinion on the safety and efficacy of l-methionine ≥ 98.5% or ≥ 90% produced by the combined activities of Corynebacterium glutamicum KCCM 80245 and Escherichia coli KCCM 80246) as nutritional additive for all animal species. The two production strains are genetically modified. l-Methionine is intended to be used in feed or water for drinking for all animal species. Neither viable cells nor recombinant DNA of the production strains were detected in the final products. The additive does not pose any safety concern associated with the genetic modification of the production strains. The use of both products of l-methionine produced by C. glutamicum KCCM 80245 and E. coli KCCM 80246 in supplementing feed to compensate for l-methionine deficiency in feedingstuffs is safe for the target species. The FEEDAP Panel has concerns about the use of amino acids in water for drinking for hygienic reasons, and due to the risk of imbalances when administered simultaneously via feed. The use of both products of l-methionine produced by C. glutamicum KCCM 80245 and E. coli KCCM 80246 in animal nutrition is considered safe for the consumers and for the environment. The additive, in either product, is not an irritant to skin/eyes and not a dermal sensitiser and shows no toxicity by inhalation. Considering the respiratory exposure to endotoxins, l-methionine ≥ 90% is a risk for the user. Both products of the additive produced by C. glutamicum KCCM 80245 and E. coli KCCM 80246 are considered as an efficacious source of the essential amino acid l-methionine for non-ruminant animal species. For the supplemental l-methionine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
- Published
- 2022
32. Safety and efficacy of a feed additive consisting of Enterococcus faecium NBIMCC 8270, Lactobacillus acidophilus NBIMCC 8242, Lactobacillus helveticus NBIMCC 8269, Lactobacillus delbrueckii ssp. lactis NBIMCC 8250, L. delbrueckii ssp. bulgaricus NBIMCC 8244 and Streptococcus thermophilus NBIMCC 8253 (Probiotic Lactina®) for chickens for fattening and suckling and weaned rabbits (Lactina Ltd.)
- Author
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Bampidis, V., Azimonti, G., Bastos, M.D.L., Christensen, H., Dusemund, B., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R.E., Woutersen, R., Anguita, M., Galobart, J., Ortuño, J., and Brozzi, R.
- Subjects
safety ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,suckling/weaned rabbits ,Veterinary (miscellaneous) ,efficacy ,chickens for fattening ,Probiotic Lactina® ,gut flora stabiliser ,zootechnical additives ,Plant Science ,Microbiology ,Animal Science and Zoology ,Parasitology ,Food Science - Published
- 2022
33. Safety and efficacy of the feed additives consisting of l‐glutamic acid and monosodium l‐glutamate monohydrate produced by Corynebacterium glutamicum NITE BP‐01681 for all animal species (METEX NOOVISTAGO)
- Author
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Bampidis, V., Azimonti, G., Bastos, M.D.L., Christensen, H., Dusemund, B., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R.E., Woutersen, R., Gropp, J., Herman, L., Tosti, L., Galobart, J., Pizzo, F., Revez, J., and Anguita, M.
- Subjects
monosodium l-glutamate monohydrate ,safety ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,l‐glutamic acid ,Veterinary (miscellaneous) ,efficacy ,Plant Science ,Microbiology ,flavouring compounds ,Corynebacterium glutamicum ,‘amino acids their salts and analogues’ ,monosodium l‐glutamate monohydrate ,Settore MED/44 - Medicina del Lavoro ,l-glutamic acid ,Animal Science and Zoology ,Parasitology ,Food Science - Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of l-glutamic acid and monosodium l-glutamate monohydrate produced by fermentation using the genetically modified strain Corynebacterium glutamicum NITE BP-01681. The additives are intended to be used in feed and water for drinking for all animal species and categories as nutritional additives (amino acids) or as sensory additives (flavouring compounds). Viable cells of the production strain and its DNA were not detected in the final additives. The additives do not give rise to any safety concern regarding the production strain. l-Glutamic acid and monosodium l-glutamate monohydrate produced using C. glutamicum NITE BP-01681 are considered safe for the target species, for the consumer and for the environment. However, the Panel raised concerns on the use in water for drinking for hygienic reasons. The additives are considered not irritant to skin or eyes and not dermal sensitisers but a risk by inhalation. The Panel concluded that the additives are efficacious as nutritional additives and as flavouring compounds.
- Published
- 2022
34. Safety of the fermentation product of Aspergillus oryzae NRRL 458 (Amaferm®) as a feed additive for dairy cows (Biozyme Inc.)
- Author
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Bampidis, V., Azimonti, G., de Lourdes Bastos, M., Christensen, H., Dusemund, B., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Edoardo Villa, R., Woutersen, R., Dierick, N., Prieto Maradona, M., Galobart, J., Pettenati, E., and Anguita, M.
- Subjects
renewal ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,Veterinary (miscellaneous) ,Amaferm ,Animal Science and Zoology ,Parasitology ,dairy cows ,Plant Science ,digestibility enhancers ,zootechnical additives ,Microbiology ,Food Science - Abstract
Amaferm® is a fermentation product produced by Aspergillus oryzae NRRL 458, containing alpha-amylase and cellulase enzyme activities, authorised for use as a feed additive for dairy cows. In 2016, the applicant requested for the renewal of the authorisation and the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) issued an opinion at that regard in 2020. In that opinion, the Panel could not confirm the previously drawn conclusions (EFSA, 2006) regarding the safety of the production strain, and consequently could not confirm the safety of the additive for the target species and consumers. In the current submission, the applicant provided supplementary information that allowed the Panel to conclude on the identity of the production strain, redefine the specifications of the additive, and finally to conclude on its safety. Therefore, the new data provided permit to conclude that Amaferm® complies with the conditions of the authorisation. However, the Panel noted that there is the need to change the specification and description of the cellulase and amylase units in the authorisation act. The data provided in the previous (EFSA FEEDAP Panel, 2020) and the current assessments support that Amaferm® remains safe under the approved conditions for target species, consumers and the environment. The additive is non-irritant to skin and eyes, or a dermal sensitiser but should be considered a potential respiratory sensitiser.
- Published
- 2022
35. Safety and efficacy of a feed additive consisting of an essential oil from the flowers of Cananga odorata (Lam.) Hook.f. & Thomson (ylang ylang oil) for use in all animal species (FEFANA asbl)
- Author
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Bampidis, V., Azimonti, G., Bastos, M.D.L., Christensen, H., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R.E., Woutersen, R., Brantom, P., Chesson, A., Westendorf, J., Manini, P., Pizzo, F., and Dusemund, B.
- Subjects
safety ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,Cananga odorata (Lam.) ,sensory additives ,Veterinary (miscellaneous) ,component‐based approach ,Plant Science ,Microbiology ,Ylang ylang oil ,essential oil ,flavouring compounds ,estragole ,β‐caryophyllene ,Animal Science and Zoology ,Parasitology ,Food Science - Published
- 2022
36. Safety and efficacy of a feed additive consisting of butylated hydroxytoluene (BHT) for all animal species (Lanxess Deutschland GmbH)
- Author
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Bampidis, V, Azimonti, G, de Lourdes Bastos, M, Christensen, H, Dusemund, B, Fasmon Durjava, M, Kouba, M, Lopez, M, Alonso, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Edoardo Villa, R, Woutersen, R, Finizio, A, Teodorovic, I, Aquilina, G, Bories, G, Gropp, J, Nebbia, C, Innocenti, M, Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fasmon Durjava, Maryline Kouba, Marta Lopez, Secundino Lopez Puente, Francesca Marcon, Baltasar Mayo, Alena Pechova, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Antonio Finizio, Ivana Teodorovic, Gabriele Aquilina, Georges Bories, Jurgen Gropp, Carlo Nebbia, Matteo Innocenti, Bampidis, V, Azimonti, G, de Lourdes Bastos, M, Christensen, H, Dusemund, B, Fasmon Durjava, M, Kouba, M, Lopez, M, Alonso, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Edoardo Villa, R, Woutersen, R, Finizio, A, Teodorovic, I, Aquilina, G, Bories, G, Gropp, J, Nebbia, C, Innocenti, M, Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fasmon Durjava, Maryline Kouba, Marta Lopez, Secundino Lopez Puente, Francesca Marcon, Baltasar Mayo, Alena Pechova, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Antonio Finizio, Ivana Teodorovic, Gabriele Aquilina, Georges Bories, Jurgen Gropp, Carlo Nebbia, and Matteo Innocenti
- Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of butylated hydroxytoluene (BHT) as a feed additive for all animal species. The additive BHT is considered safe for chickens for fattening and weaned piglets at the maximum proposed concentration of 150 mg/kg complete feed. This conclusion is extended to chickens reared for laying and extrapolated to pigs for fattening. In the absence of data, no conclusion on the safety for the other target species could be drawn. The exposure of the consumer to BHT from tissues and products of animals fed the additive ranged from 1% to 3% of the acceptable daily intake (ADI). The FEEDAP Panel concluded that the use of BHT as a feed additive at the proposed conditions of use is of no concern for the safety of the consumers. Exposure of the user to BHT via inhalation is likely; however, the Panel is not in the position to conclude on the potential inhalation toxicity of the additive. BHT is a skin and eye irritant, no conclusions can be drawn on the potential of the additive to be a skin sensitiser. In the absence of data, the FEEDAP Panel cannot conclude on the safety of BHT for the environment. The additive BHT is considered an efficacious antioxidant in feedingstuffs for all animal species.
- Published
- 2022
37. Safety and efficacy of a feed additive consisting of butylated hydroxytoluene (BHT) for all animal species (Katyon Technologies Limited)
- Author
-
Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Fašmon Durjava, M, Kouba, M, López-Alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Teodorovic, I, Aquilina, G, Bories, G, Gropp, J, Nebbia, C, Innocenti, M, Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Fašmon Durjava, Mojca, Kouba, Maryline, López-Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Finizio, Antonio, Teodorovic, Ivana, Aquilina, Gabriele, Bories, Georges, Gropp, Jurgen, Nebbia, Carlo, Innocenti, Matteo, Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Fašmon Durjava, M, Kouba, M, López-Alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Teodorovic, I, Aquilina, G, Bories, G, Gropp, J, Nebbia, C, Innocenti, M, Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Fašmon Durjava, Mojca, Kouba, Maryline, López-Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Finizio, Antonio, Teodorovic, Ivana, Aquilina, Gabriele, Bories, Georges, Gropp, Jurgen, Nebbia, Carlo, and Innocenti, Matteo
- Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of butylated hydroxytoluene (BHT) as a feed additive for all animal species. The additive BHT is considered safe for chickens for fattening and weaned piglets at the maximum proposed concentration of 150 mg/kg complete feed. This conclusion is extended to chickens reared for laying and extrapolated to pigs for fattening. In the absence of data, no conclusion on the safety for the other target species could be drawn. The exposure of the consumer to BHT from tissues and products of animals fed the additive ranged from 1% to 3% of the acceptable daily intake (ADI). The FEEDAP Panel concluded that the use of BHT as a feed additive at the proposed conditions of use is of no concern for the safety of the consumers. Exposure of the user to BHT via inhalation is likely; however, the Panel is not in the position to conclude on the potential inhalation toxicity of the additive. BHT is a skin and eye irritant, no conclusions can be drawn on the potential of the additive to be a skin sensitiser. In the absence of data, the FEEDAP Panel cannot conclude on the safety of BHT for the environment. The additive BHT is considered an efficacious antioxidant in feedingstuffs for all animal species.
- Published
- 2022
38. Safety and efficacy of a feed additive consisting of ethoxyquin (6‐ethoxy‐1,2‐dihydro‐2,2,4‐trimethylquinoline) for all animal species (FEFANA asbl)
- Author
-
Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Fašmon Durjava, M, Kouba, M, López‐alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Teodorovic, I, Aquilina, G, Bories, G, Gropp, J, Nebbia, C, Tarrés‐call, J, Innocenti, M, Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Fašmon Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Finizio, Antonio, Teodorovic, Ivana, Aquilina, Gabriele, Bories, Georges, Gropp, Jurgen, Nebbia, Carlo, Tarrés‐Call, Jordi, Innocenti, Matteo, Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Fašmon Durjava, M, Kouba, M, López‐alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Teodorovic, I, Aquilina, G, Bories, G, Gropp, J, Nebbia, C, Tarrés‐call, J, Innocenti, M, Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Fašmon Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Finizio, Antonio, Teodorovic, Ivana, Aquilina, Gabriele, Bories, Georges, Gropp, Jurgen, Nebbia, Carlo, Tarrés‐Call, Jordi, and Innocenti, Matteo
- Abstract
Ethoxyquin is synthetised from p-phenetidine, a possible mutagen, which remains in the additive as an impurity at concentrations of < 2.5 mg/kg additive. Ethoxyquin is considered safe for all animal species at the proposed inclusion level of 50 mg/kg complete feed. However, owing the presence of p-phenetidine, no safe level of the additive in feed for long-living and reproductive animals could be identified. The FEEDAP Panel derived a health-based guidance value of 0.006 mg ethoxyquin dimer (EQDM)/kg bw per day and applied it to the sum of ethoxyquin and its transformation products. A maximum total concentration of 50 mg ethoxyquin/kg complete feed for all animal species, except dairy ruminants, would not pose a risk for the consumer. However, in the absence of data on p-phenetidine residues in tissues and products of animal origin, no conclusion on the safety for the consumer could be drawn. The conclusions on consumer safety assume that the maximum total concentration of 50 mg EQ/kg feed is expressed as the sum of EQ, EQDM, EQI and DHEQ. Exposure of the unprotected user to p-phenetidine via inhalation should be minimised. No safety concerns for groundwater are expected. It is not possible to conclude on the safety of EQ for the terrestrial compartment. A risk for the aquatic compartment cannot be excluded when ethoxyquin is used in terrestrial animals. Unacceptable risk is not expected for freshwater sediment-dwelling organisms. A risk of secondary poisoning via the terrestrial food chain is not expected, whereas a risk via the aquatic food chain cannot be excluded. No concerns for aquatic organisms are expected for ethoxyquin used in fish farmed in land-based system, a risk cannot be excluded for marine sediment dwelling organisms when ethoxyquin is used in sea-cages. Ethoxyquin is considered efficacious in the range 25–50 mg/kg complete feed.
- Published
- 2022
39. List of Contributors
- Author
-
Benítez-Páez, A., primary, Brummer, R.J., additional, Callegari, M.L., additional, Clarke, G., additional, Cotter, P.D., additional, Crispie, F., additional, Cryan, J.F., additional, de Timary, P., additional, de Vos, W.M., additional, Deane, J., additional, Delzenne, N.M., additional, Dinan, T.G., additional, Federici, S., additional, Fitzgerald, G., additional, Fouhy, F., additional, Gareau, M.G., additional, Ghomi, R.H., additional, Gómez Del Pulgar, E.M., additional, Guinane, C.M., additional, Hayes, C.L., additional, Holster, S., additional, Hsiao, E.Y., additional, Huynh, K., additional, Jacka, F.N., additional, Kirchgessner, A., additional, König, J., additional, Leclercq, S., additional, Luczynski, P., additional, Lyte, M., additional, Marques, T.M., additional, McVey Neufeld, K.A., additional, Morelli, L., additional, Mungovan, K., additional, Murphy, A.B., additional, Nemani, K., additional, Neto, M.C., additional, O’ Mahony, S.M., additional, O’Toole, P.W., additional, Plant, B.J., additional, Portune, K., additional, Quigley, E.M.M., additional, Ratcliffe, E.M., additional, Rea, M.C., additional, Reid, G., additional, Ross, R.P., additional, Ryan, P.M., additional, Sanz, Y., additional, Schneider, M., additional, Shanahan, F., additional, Stanton, C., additional, Stärkel, P., additional, Sudo, N., additional, Thomas, A., additional, Verdu, E.F., additional, Wall, R., additional, and Yano, J.M., additional
- Published
- 2016
- Full Text
- View/download PDF
40. Targeting the Microbiota
- Author
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Sanz, Y., primary, Portune, K., additional, Gómez Del Pulgar, E.M., additional, and Benítez-Páez, A., additional
- Published
- 2016
- Full Text
- View/download PDF
41. Bifidobacteria in Foods: Health Effects
- Author
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Sanz, Y., primary
- Published
- 2016
- Full Text
- View/download PDF
42. Species- and strain-level assessment using rrn long-amplicons suggests donor's influence on gut microbial transference via fecal transplants in metabolic syndrome subjects
- Author
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Benítez-Páez A, Hartstra AV, Nieuwdorp M, and Sanz Y
- Subjects
MinION, Nanopore sequencing, gut microbiota, rrn operon, single-nucleotide variation, species engraftment, species-level resolution - Abstract
Fecal microbiota transplantation (FMT) is currently used for treating Clostridium difficile infection and explored for other clinical applications in experimental trials. However, the effectiveness of this therapy could vary, and partly depend on the donor's bacterial species engraftment, whose evaluation is challenging because there are no cost-effective strategies for accurately tracking the microbe transference. In this regard, the precise identification of bacterial species inhabiting the human gut is essential to define their role in human health unambiguously. We used Nanopore-based device to sequence bacterial rrn operons (16S-ITS-23S) and to reveal species-level abundance changes in the human gut microbiota of a FMT trial. By assessing the donor and recipient microbiota before and after FMT, we further evaluated whether this molecular approach reveals strain-level genetic variation to demonstrate microbe transfer and engraftment. Strict control over sequencing data quality and major microbiota covariates was critical for accurately estimating the changes in gut microbial species abundance in the recipients after FMT. We detected strain-level variation via single-nucleotide variants (SNVs) at rrn regions in a species-specific manner. We showed that it was possible to explore successfully the donor-bacterial strain (e.g., Parabacteroides merdae) engraftment in recipients of the FMT by assessing the nucleotide frequencies at rrn-associated SNVs. Our findings indicate that the engraftment of donors' microbiota is to some extent correlated with the improvement of metabolic health in recipients and that parameters such as the baseline gut microbiota configuration, sex, and age of donors should be considered to ensure the success of FMT in humans. The study was prospectively registered at the Dutch Trial registry - NTR4488 (https://www.trialregister.nl/trial/4488).
- Published
- 2022
43. Safety and efficacy of a feed additive consisting of astaxanthin-rich Phaffia rhodozyma for salmon and trout (Igene Biotechnology, Inc.)
- Author
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Bampidis, V., Azimonti, G., Bastos, M.D.L., Christensen, H., Dusemund, B., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R.E., Woutersen, R., Galobart, J., Holcznecht, O., and Vettori, M.V.
- Subjects
safety ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,trout ,Veterinary (miscellaneous) ,efficacy ,salmon ,Plant Science ,sensory additive ,Phaffia rhodozyma ,astaxanthin ,colourant ,Microbiology ,Animal Science and Zoology ,Parasitology ,Food Science - Abstract
Following a request from the European Commission, the FEEDAP Panel was asked to deliver a scientific opinion on the safety and efficacy of astaxanthin (ATX)-rich Phaffia rhodozyma. The additive, belonging to the category ‘sensory additives’ and the functional group ‘substances which, when fed to animals, add colours to food of animal origin’ is intended to be used in feed for salmon and trout from an age of six months onwards up to a maximum content of 100 mg ATX/kg complete feed. The product is produced by the telemorph of Phaffia rhodozyma, Xanthophyllomyces dendrorhous, and it is declared to contain 995 g dried inactivated biomass and 5 g ascorbic acid per kg additive. The main active principle of the additive is ATX; however, the FEEDAP Panel noted that some other carotenoids are also present in lower quantities. The minimum ATX concentration is specified to be 5,000 mg per kg additive. The yeast Xanthophyllomyces dendrorhous is considered by EFSA to be suitable for the qualified presumption of safety (QPS) approach to safety assessment; therefore, the use of the production strain in the production of the additive would not raise any safety concern for the target species, the consumers of products from animals fed the additive and the environment. In the absence of a tolerance study with the additive, the FEEDAP Panel cannot conclude on the safety for the target species. In the absence of residue and toxicity data of ATX, no final conclusions on the safety for the consumer can be drawn. The FEEDAP Panel concluded that the additive is irritant to skin and eyes, and a skin and respiratory sensitiser, although exposure by inhalation is likely low. The FEEDAP Panel considers that ATX from the biomass does not pose a significant additional risk to the environment compared with other natural sources of ATX. In absence of adequate evidence, no conclusion can be made on the efficacy of the additive.
- Published
- 2022
44. Assessment of the feed additive consisting of Lentilactobacillus buchneri (formerly Lactobacillus buchneri) DSM 12856 for all animal species for the renewal of its authorisation (Lactosan GmbH & Co KG)
- Author
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Bampidis, V., Azimonti, G., Bastos, M.D.L., Christensen, H., Dusemund, B., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R.E., Woutersen, R., Galobart, J., Vettori, M.V., and Brozzi, R.
- Subjects
renewal ,safety ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,Lentilactobacillus buchneri DSM 12856 ,QPS ,efficacy ,silage additive ,technological additive ,Veterinary (miscellaneous) ,Plant Science ,Microbiology ,Animal Science and Zoology ,Parasitology ,Food Science - Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of Lentilactobacillus buchneri (formerly Lactobacillus buchneri) DSM 12856 as a technological additive for use in forage for all animal species. The additive aims at improving the production of silage and is authorised for all animal species. The applicant has provided evidence that the additive currently on the market complies with the existing conditions of authorisation. There is no evidence to lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the Panel concludes that the additive remains safe for all animal species, consumers and the environment under the authorised conditions of use. Regarding user safety L. buchneri DSM 12856 is not irritant to skin and eyes but is considered a skin and respiratory sensitiser. There was no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.
- Published
- 2022
45. Safety and efficacy of a feed additive consisting of Bacillus velezensis NITE BP-01844 (BA-KING®) for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding and all avian species for fattening, or rearing to slaughter or point of lay including non-food producing species (Toa Biopharma Co., Ltd.)
- Author
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Bampidis, V., Azimonti, G., Bastos, M.D.L., Christensen, H., Dusemund, B., Kouba, M., Fašmon Durjava, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R.E., Woutersen, R., Brantom, P., Maradona, M.P., Anguita, M., Galobart, J., Pettenati, E., and Revez, J.
- Subjects
safety ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,Bacillus velezensis NITE BP-01844 ,gut flora stabilisers ,Bacillus velezensis NITE BP‐01844 ,Veterinary (miscellaneous) ,efficacy ,BA-KING ,Plant Science ,Microbiology ,QPS ,zootechnical additive ,BA‐KING® ,Animal Science and Zoology ,Parasitology ,Food Science - Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of BA-KING® Bacillus velezensis when used as a feed additive for chickens for fattening, turkeys for fattening, chickens reared for laying, turkeys reared for breeding and all avian species for fattening, or rearing to slaughter or point of lay including non-food producing species. The product under assessment is based on viable spores of a strain identified as B. velezensis, which is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The identity of the active agent was established, and it does not harbour acquired antimicrobial resistance genes, lacks toxigenic potential and does not have the capacity to produce aminoglycosides. Following the QPS approach to safety assessment, B. velezensis NITE BP-01844 is presumed safe for the target species, consumers of products derived from animals fed the additive and the environment. Since no concerns are expected from the other components of the additive, BA-KING® is also considered safe for the target species, consumers of products derived from animals fed the additive and the environment. BA-KING® is not irritant to skin but is potentially irritant to eyes. In addition, should be considered a skin and respiratory sensitiser. The Panel is not in the position to conclude on the efficacy of BA-KING® for the target species.
- Published
- 2022
46. Safety and efficacy of a feed additive consisting of Propionibacterium freudenreichii DSM 33189 and Lentilactobacillus buchneri (formerly Lactobacillus buchneri) DSM 12856 for all animal species (Lactosan GmbH & Co.KG.)
- Author
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Bampidis, V., Azimonti, G., Bastos, M.D.L., Christensen, H., Dusemund, B., Fašmon Durjava, M., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R.E., Woutersen, R., Brozzi, R., Galobart, J., Innocenti, M., and Revez, J.
- Subjects
safety ,Settore VET/07 - Farmacologia e Tossicologia Veterinaria ,silage additive ,Veterinary (miscellaneous) ,efficacy ,Lentilactobacillus buchneri (formerly Lactobacillus buchneri) DSM 12856 ,Propionibacterium freudenreichii DSM 33189 ,QPS ,technological additive ,Plant Science ,Microbiology ,Animal Science and Zoology ,Parasitology ,Food Science - Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of an additive consisting of Propionibacterium freudenreichii DSM 33189 and Lentilactobacillus buchneri (formerly Lactobacillus buchneri) DSM 12856 as a technological additive for all animal species. The additive is intended to improve the production of silage at a proposed application rate of 1 × 108 colony-forming units (CFU)/kg fresh material. The bacterial species P. freudenreichii and L. buchneri are considered by EFSA to be suitable for the qualified presumption of safety (QPS) approach to assessment. As the identity of the strains has been clearly established and no acquired antimicrobial resistance determinants of concern were detected, the use of the strains as a silage additive is considered safe for livestock species, for consumers and for the environment. The additive is not irritant for eyes or skin but should be considered a respiratory sensitiser. In the absence of data, the FEEDAP Panel could not conclude on the potential of the additive to be a skin sensitiser. The additive at the proposed application rate of 1 × 108 CFU/kg fresh plant material showed the potential to improve the aerobic stability silage with dry matter content ranging from 30% to 70%.
- Published
- 2022
47. Safety and efficacy of Elancoban® G200 (monensin sodium) for chickens for fattening, chickens reared for laying and turkeys
- Author
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Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kos Durjava, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Bories, G, Brantom, P, Gropp, J, Finizio, A, Focks, A, Teodorovic, I, Glandorf, B, Herman, L, Prieto Maradona, M, Holczknecht, O, Tarres-Call, J, Vettori, M, Kouba, M, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kos Durjava M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Bories G., Brantom P., Gropp J., Finizio A., Focks A., Teodorovic I., Glandorf B., Herman L., Prieto Maradona M., Holczknecht O., Tarres-Call J., Vettori M. V., Kouba M., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kos Durjava, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Bories, G, Brantom, P, Gropp, J, Finizio, A, Focks, A, Teodorovic, I, Glandorf, B, Herman, L, Prieto Maradona, M, Holczknecht, O, Tarres-Call, J, Vettori, M, Kouba, M, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kos Durjava M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Bories G., Brantom P., Gropp J., Finizio A., Focks A., Teodorovic I., Glandorf B., Herman L., Prieto Maradona M., Holczknecht O., Tarres-Call J., Vettori M. V., and Kouba M.
- Abstract
The feed additive Elancoban® G200, containing the active substance monensin sodium, an ionophore anticoccidial, is intended to control coccidiosis in chickens for fattening, chickens reared for laying and turkeys. The FEEDAP Panel cannot conclude on the safety of the additive for the target species, consumer, user and environment with regard to the safety of the production strain. The following conclusions apply to monensin sodium included in the additive. Based on the available data set, the FEEDAP Panel cannot conclude on the safety of Elancoban® G200 for chickens for fattening. Monensin sodium is safe for turkeys for fattening with a margin of safety of 1.5. Monensin sodium is not genotoxic and not carcinogenic. The pharmacological no observed adverse effect level (NOAEL) of 0.345 mg monensin sodium/kg body weight (bw) per day was identified in dog. The acceptable daily intake (ADI) derived from this NOAEL is 0.003 mg monensin sodium/kg bw applying an uncertainty factor of 100. Elancoban® G200 is safe for the consumer. The existing maximum residue limits (MRLs) ensure consumer safety, provided that the withdrawal period of 1 day is respected. Elancoban® G200 is very irritant for the eye, but it is not a skin irritant. Elancoban® G200 should be regarded as a potential skin and respiratory sensitiser. Inhalation exposure is considered a risk to persons handling the additive. Elancoban® G200 does not pose a risk for the terrestrial compartment, the aquatic compartment and the sediment. The bioaccumulation potential of monensin in the environment is low. Monensin sodium from Elancoban® G200 has the potential to effectively control coccidiosis in chickens for fattening and chickens reared for laying. The FEEDAP Panel cannot conclude on the efficacy Elancoban® G200 as a coccidiostat for turkeys for fattening.
- Published
- 2019
48. Safety of Lancer® (lanthanide citrate) as a zootechnical additive for weaned piglets
- Author
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Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kouba, M, Kos Durjava, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Focks, A, Svensson, K, Teodorovic, I, Tosti, L, Tarres-Call, J, Manini, P, Pizzo, F, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kouba M., Kos Durjava M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Focks A., Svensson K., Teodorovic I., Tosti L., Tarres-Call J., Manini P., Pizzo F., Bampidis, V, Azimonti, G, Bastos, M, Christensen, H, Dusemund, B, Kouba, M, Kos Durjava, M, Lopez-Alonso, M, Lopez Puente, S, Marcon, F, Mayo, B, Pechova, A, Petkova, M, Ramos, F, Sanz, Y, Villa, R, Woutersen, R, Finizio, A, Focks, A, Svensson, K, Teodorovic, I, Tosti, L, Tarres-Call, J, Manini, P, Pizzo, F, Bampidis V., Azimonti G., Bastos M. D. L., Christensen H., Dusemund B., Kouba M., Kos Durjava M., Lopez-Alonso M., Lopez Puente S., Marcon F., Mayo B., Pechova A., Petkova M., Ramos F., Sanz Y., Villa R. E., Woutersen R., Finizio A., Focks A., Svensson K., Teodorovic I., Tosti L., Tarres-Call J., Manini P., and Pizzo F.
- Abstract
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the additional data submitted on Lancer® when used as a feed additive for weaned piglets. The FEEDAP Panel considered that uncertainty still remains on possible developmental neurotoxicity of Lancer® since it was unable to identify a no observed adverse effect level (NOAEL) for this specific endpoint applying a read-across strategy from the studies provided by the applicant. However, the FEEDAP Panel considered that the exposure to La and Ce from products of animals treated with Lancer® at 250 mg/kg feed would not add a significant contribution to the background exposure of these elements. The FEEDAP Panel concluded that the use of Lancer® in feed for weaned piglets (up to 120 days) according to the proposed conditions of use, does not represent a safety concern for the consumer and for the environment.
- Published
- 2019
49. The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease
- Author
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Olivares, M, Neef, A, Castillejo, G, De Palma, G, Varea, V, Capilla, A, Palau, F, Nova, E, Marcos, A, Polanco, I, Ribes-Koninckx, C, Ortigosa, L, Izquierdo, L, and Sanz, Y
- Published
- 2015
- Full Text
- View/download PDF
50. Microbiota and host determinants of behavioural phenotype in maternally separated mice
- Author
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De Palma, G., Blennerhassett, P., Lu, J., Deng, Y., Park, A. J., Green, W., Denou, E., Silva, M. A., Santacruz, A., Sanz, Y., Surette, M. G., Verdu, E. F., Collins, S. M., and Bercik, P.
- Published
- 2015
- Full Text
- View/download PDF
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