Search

Your search keyword '"Sanz, G.A."' showing total 3 results
Start Over Author "Sanz, G.A."
3 results on '"Sanz, G.A."'

1. Thrombolysis with tissue plasminogen activator in acute myocardial infarction: no additional benefit from immediate percutaneous coronary angioplasty

Author

Simoons, M.L., Betriu, A., Col, J., Von Essen, R., Lubsen, J., Michel, P.L., Rutsch, W., Schmidt, W., Thery, C., Vahanian, A., Willems, G.M., Arnold, A.E.R., DeBono, D.P., Lambertz, H., Meier, B., Raynaud, P., Dougherty, F.C., Sanz, G.A., Serruys, P.W., Uebis, R., Van De Werf, F., Wood, D., and Verstraete, M.

Subjects
Heart attack, Angioplasty -- Case studies, Coronary heart disease -- Care and treatment
Published
1988

2. Thrombolysis with tissue plasminogen activator in acute myocardial infarction: no additional benefit from immediate percutaneous coronary angioplasty

Author

Simoons, M.L. (Maarten), Betriu, A., Col, J.J. (Jacques), Essen, R. von, Lubsen, J. (Jacob), Michel, P.L., Rutsch, W.R. (Wolfgang), Schmidt, W., Thery, C., Vahanian, A.S. (Alec), Willems, G.M. (George), Bono, D.P. (David) de, Dougherty, F.C., Lambertz, H., Meier, B. (Bernard), Raynaud, P. (Philippe), Sanz, G.A., Serruys, P.W.J.C. (Patrick), Uebis, R., Wood, D., Verstraete, M. (Marc), Arnold, A.E.R. (Alfred), Werf, F.J.J. (Frans) van de, Simoons, M.L. (Maarten), Betriu, A., Col, J.J. (Jacques), Essen, R. von, Lubsen, J. (Jacob), Michel, P.L., Rutsch, W.R. (Wolfgang), Schmidt, W., Thery, C., Vahanian, A.S. (Alec), Willems, G.M. (George), Bono, D.P. (David) de, Dougherty, F.C., Lambertz, H., Meier, B. (Bernard), Raynaud, P. (Philippe), Sanz, G.A., Serruys, P.W.J.C. (Patrick), Uebis, R., Wood, D., Verstraete, M. (Marc), Arnold, A.E.R. (Alfred), and Werf, F.J.J. (Frans) van de

Abstract

A randomised trial of 367 patients with acute myocardial infarction was performed to determine whether an invasive strategy combining thrombolysis with recombinant tissue-type plasminogen activator (rTPA), heparin, and acetylsalicylic acid, and immediate percutaneous transluminal coronary angioplasty (PTCA) would be superior to a noninvasive strategy with the same medical treatment but without immediate angiography and PTCA. Intravenous infusion of 100 mg rTPA was started within 5 h after onset of symptoms (median 156 min). Angiography was performed 6-165 min later in 180 out of 183 patients allocated to the invasive strategy; 184 patients were allocated to the non-invasive strategy. Immediate PTCA reduced the percentage stenosis of the infarct

Published
1988

3. Thrombolysis with rt-PA in acute myocardial infarction: no additional benefit of immediate PTCA

Author

Simoons, M.L. (Maarten), Betriu, A., Bokslag, M., Bono, D.P. (David) de, Brower, R.W. (Ronald), Col, J.J. (Jacques), Dougherty, F.C., Essen, R. von, Lambertz, H., Lubsen, J. (Jacob), Meier, B. (Bernard), Michel, P.L., Raynaud, P. (Philippe), Rutsch, W.R. (Wolfgang), Sanz, G.A., Schmidt, W., Serruys, P.W.J.C. (Patrick), Thery, C., Uebis, R., Vahanian, A.S. (Alec), Willems, G.M. (George), Wood, D., Verstraete, M. (Marc), Arnold, A.E.R. (Alfred), Werf, F.J.J. (Frans) van de, Simoons, M.L. (Maarten), Betriu, A., Bokslag, M., Bono, D.P. (David) de, Brower, R.W. (Ronald), Col, J.J. (Jacques), Dougherty, F.C., Essen, R. von, Lambertz, H., Lubsen, J. (Jacob), Meier, B. (Bernard), Michel, P.L., Raynaud, P. (Philippe), Rutsch, W.R. (Wolfgang), Sanz, G.A., Schmidt, W., Serruys, P.W.J.C. (Patrick), Thery, C., Uebis, R., Vahanian, A.S. (Alec), Willems, G.M. (George), Wood, D., Verstraete, M. (Marc), Arnold, A.E.R. (Alfred), and Werf, F.J.J. (Frans) van de

Abstract

A randomised trial of 367 patients with acute myocardial infarction was performed to determine whether an invasive strategy combining thrombolysis with recombinant tissue-type plasminogen activator (rTPA), heparin, and acetylsalicylic acid, and immediate percutaneous transluminal coronary angioplasty (PTCA) would be superior to a noninvasive strategy with the same medical treatment but without immediate angiography and PTCA. Intravenous infusion of 100 mg rTPA was started within 5 h after onset of symptoms (median 156 min). Angiography was performed 6-165 min later in 180 out of 183 patients allocated to the invasive strategy; 184 patients were allocated to the non-invasive strategy. Immediate PTCA reduced the percentage stenosis of the infarct-related segment, but this was offset by a high rate of transient (16%) and sustained (7%) reocclusion during the procedure and recurrent ischaemia during the first 24 h (17%). The clinical course was more favourable after non-invasive therapy, with a lower incidence of recurrent ischaemia within 24 h (3%), bleeding complications, hypotension, and ventricular fibrillation. Mortality at 14 days was lower in patients allocated to non-invasive treatment (3%) than in the group allocated to invasive treatment (7%). No difference between the treatment groups was observed in infarct size estimated from myocardial release of alpha-hydroxybutyrate dehydrogenase or in left ventricular ejection fraction after 10-22 days. Since immediate PTCA does not provide additional benefit there seems to be no need for immediate angiography and PTCA in patients with acute myocardial infarction treated with rTPA.

Published
1988

Catalog

Books, media, physical & digital resources
See catalog results