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1. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis, Craig R. G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024
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2. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, and Monici, Monica

Published
2024
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3. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., and Monici, Monica

Published
2023
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5. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Davis, Trent [0000-0001-5704-0335], Tabury, Kevin [0000-0002-8004-3718], Zhu, Shouan [0000-0002-4973-1504], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, Monici, Monica, Davis, Trent [0000-0001-5704-0335], Tabury, Kevin [0000-0002-8004-3718], Zhu, Shouan [0000-0002-4973-1504], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, and Monici, Monica

Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.

Published
2024

6. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, Szewczyk, Nathaniel, Federal Ministry of Economics and Technology (Germany), Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Cialdai, Francesca [0000-0002-2290-0566], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Risaliti, Chiara [0000-0003-1695-0548], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Monici, Monica [0000-0001-6678-9241], Szewczyk, Nathaniel [0000-0003-4425-9746], Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Monici, Monica, and Szewczyk, Nathaniel

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024

7. When Nerve Growth Factor Met Behavior

Author

Santucci, Daniela, Racca, Arianna, Alleva, Enrico, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Calzà, Laura, editor, Aloe, Luigi, editor, and Giardino, Luciana, editor

Published
2021
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9. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, Monici, Monica, Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Davis, Trent, Tabury, Kevin, Zhu, Shouan, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack J.W.A., Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel, and Monici, Monica

Published
2024

10. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J., Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024

11. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Cialdai, Francesca [0000-0002-2290-0566], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Risaliti, Chiara [0000-0003-1695-0548], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Strollo, Felice [0000-0001-8917-5314], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, Monici, Monica, Cialdai, Francesca [0000-0002-2290-0566], Angeloni, Debora [0000-0002-3850-5392], Baatout, Sarah [0000-0001-8110-751X], Benchoua, Alexandra [0000-0002-9980-6471], Bottai, Daniele [0000-0002-7951-9512], Buchheim, Judith-Irina [0000-0003-3605-955X], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Castiglioni, Sara [0000-0002-8785-9891], Cavalieri, Duccio [0000-0001-6426-5719], Choukér, Alexander [0000-0002-0133-4104], Ciofani, Gianni [0000-0003-1192-3647], Cusella, Gabriella [0000-0003-2642-3346], Degl'Innocenti, Andrea [0000-0002-5204-5601], Desaphy, Jean-Francois [0000-0001-8816-9369], Frippiat, Jean-Pol [0000-0002-4027-6269], Gelinsky, Michael [0000-0001-9075-5121], Genchi, Giada [0000-0002-2154-7991], Grano, Maria [0000-0002-7121-5899], Grimm, Daniela [0000-0002-4991-3105], Guignandon, Alain [0000-0002-0745-5417], Hatton, Jason [0000-0002-5763-2944], Herranz, Raúl [0000-0002-0246-9449], Hellweg, Christine E. [0000-0002-2223-3580], Iorio, Carlo Saverio [0000-0003-0952-0064], Karapantsios, Thodoris [0000-0001-6641-3359], van Loon, Jack JWA [0000-0001-9051-6016], Lulli, Matteo [0000-0002-8528-4094], Malda, Jos [0000-0002-9241-7676], Morbidelli, Lucia [0000-0001-8148-7049], Van Ombergen, Angelique [0000-0002-3977-4279], Osterman, Andreas [0000-0001-5435-5972], Ovsianikov, Aleksandr [0000-0001-5846-0198], Pampaloni, Francesco [0000-0003-4357-7320], Przybyla, Cyrille [0000-0001-8093-8426], Rettberg, Petra [0000-0003-4439-2395], Risaliti, Chiara [0000-0003-1695-0548], Rizzo, Angela Maria [0000-0002-8582-0432], Robson-Brown, Kate [0000-0003-4797-8965], Rossi, Leonardo [0000-0003-4974-3860], Russo, Giorgio [0000-0003-1493-1087], Salvetti, Alessandra [0000-0002-9154-9773], Santucci, Daniela [0000-0002-4619-1290], Sperl, Matthias [0000-0001-9525-0368], Strollo, Felice [0000-0001-8917-5314], Tabury, Kevin [0000-0002-8004-3718], Tavella, Sara [0000-0003-1478-4910], Thielemann, Christiane [0000-0002-9814-4744], Willaert, R. [0000-0002-5400-7019], Szewczyk, Nathaniel [0000-0003-4425-9746], Monici, Monica [0000-0001-6678-9241], Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Díaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack JWA, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, R., Szewczyk, Nathaniel, and Monici, Monica

Abstract

The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.

Published
2023

14. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Equine Musculoskeletal Biology, CS_Locomotion, Locomotion - Equine Sciences, Cialdai, Francesca, Brown, Austin M, Baumann, Cory W, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J, Monici, Monica, Equine Musculoskeletal Biology, CS_Locomotion, Locomotion - Equine Sciences, Cialdai, Francesca, Brown, Austin M, Baumann, Cory W, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J, and Monici, Monica

Published
2023

15. General and species-specific recommendations for minimal requirements for the use of cephalopods in scientific research

Author

Ponte, Giovanna, Roumbedakis, Katina, COST Action FA1301, Galligioni, Viola, Dickel, Ludovic, Bellanger, Cécile, Pereira, Joao, Vidal, Erica Ag, Grigoriou, Panos, Alleva, Enrico, Santucci, Daniela, Gili, Claudia, Botta, Giovanni, Imperadore, Pamela, Tarallo, Andrea, Juergens, Lars, Northrup, Emily, Anderson, David, Aricò, Arianna, De Luca, Marianna, Pieroni, Eleonora Maria, Fiorito, Graziano, Ponte, Giovanna, Roumbedakis, Katina, COST Action FA1301, Galligioni, Viola, Dickel, Ludovic, Bellanger, Cécile, Pereira, Joao, Vidal, Erica Ag, Grigoriou, Panos, Alleva, Enrico, Santucci, Daniela, Gili, Claudia, Botta, Giovanni, Imperadore, Pamela, Tarallo, Andrea, Juergens, Lars, Northrup, Emily, Anderson, David, Aricò, Arianna, De Luca, Marianna, Pieroni, Eleonora Maria, and Fiorito, Graziano

Abstract

Here we list species-specific recommendations for housing, care and management of cephalopod molluscs employed for research purposes with the aim of contributing to the standardization of minimum requirements for establishments, care and accommodation of these animals in compliance with the principles stated in Directive 2010/63/EU. Maximizing their psychophysical welfare was our priority. General recommendations on water surface area, water depth and tank shape here reported represent the outcome of the combined action of the analysis of the available literature and an expertise-based consensus reached - under the aegis of the COST Action FA1301 - among researchers working with the most commonly used cephalopod species in Europe. Information on water supply and quality, environmental conditions, stocking density, feeding and handling are also provided. Through this work we wish to set the stage for a more fertile ground of evidence-based approaches on cephalopod laboratory maintenance, thus facilitating standardization and replicability of research outcomes across laboratories, at the same time maximizing the welfare of these animals.

Published
2023

16. How do gravity alterations affect animal and human systems at a cellular/tissue level?

Author

Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., Monici, Monica, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cialdai, Francesca, Brown, Austin M., Baumann, Cory W., Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Calvaruso, Marco, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Choukér, Alexander, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Hahn, Christiane, Hatton, Jason, Herranz, Raúl, Hellweg, Christine E., Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, van Ombergen, Angelique, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Puhl, Christopher, Rettberg, Petra, Risaliti, Chiara, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Santucci, Daniela, Sperl, Matthias, Strollo, Felice, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Szewczyk, Nathaniel J., and Monici, Monica

Published
2023

17. Circulating and Salivary NGF and BDNF Levels in SARS-CoV-2 Infection: Potential Predictor Biomarkers of COVID-19 Disease—Preliminary Data

Author

Biamonte, Filippo, primary, Re, Agnese, additional, Balzamino, Bijorn Omar, additional, Ciasca, Gabriele, additional, Santucci, Daniela, additional, Napodano, Cecilia, additional, Nocca, Giuseppina, additional, Fiorita, Antonella, additional, Marino, Mariapaola, additional, Basile, Umberto, additional, Micera, Alessandra, additional, and Callà, Cinzia Anna Maria, additional

Published
2022
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18. Circulating and Salivary NGF and BDNF Levels in SARS-CoV-2 Infection: Potential Predictor Biomarkers of COVID-19 Disease-Preliminary Data

Author

Biamonte, Filippo, Re, Agnese, Balzamino, Bijorn Omar, Ciasca, Gabriele, Santucci, Daniela, Napodano, Cecilia, Nocca, Giuseppina, Fiorita, Antonella, Marino, Mariapaola, Basile, Umberto, Micera, Alessandra, Calla', Cinzia Anna Maria, Biamonte, Filippo (ORCID:0000-0003-1327-7642), Ciasca, Gabriele (ORCID:0000-0002-3694-8229), Napodano, Cecilia (ORCID:0000-0002-8720-6284), Nocca, Giuseppina (ORCID:0000-0002-2799-4557), Marino, Mariapaola (ORCID:0000-0001-9155-6378), Callà, Cinzia Anna Maria (ORCID:0000-0001-7962-1229), Biamonte, Filippo, Re, Agnese, Balzamino, Bijorn Omar, Ciasca, Gabriele, Santucci, Daniela, Napodano, Cecilia, Nocca, Giuseppina, Fiorita, Antonella, Marino, Mariapaola, Basile, Umberto, Micera, Alessandra, Calla', Cinzia Anna Maria, Biamonte, Filippo (ORCID:0000-0003-1327-7642), Ciasca, Gabriele (ORCID:0000-0002-3694-8229), Napodano, Cecilia (ORCID:0000-0002-8720-6284), Nocca, Giuseppina (ORCID:0000-0002-2799-4557), Marino, Mariapaola (ORCID:0000-0001-9155-6378), and Callà, Cinzia Anna Maria (ORCID:0000-0001-7962-1229)

Abstract

COVID-19 continues to afflict the global population, causing several pathological diseases and exacerbating co-morbidities due to SARS-CoV-2's high mutation. Recent interest has been devoted to some neuronal manifestations and to increased levels of Nerve Growth Factor (NGF) and Brain-derived Neurotrophic Factor (BDNF) in the bloodstream during SARS-CoV-2 infection, neurotrophins that are well-known for their multifactorial actions on neuro-immune-endocrine and visual functions. Nineteen (19) patients were enrolled in this monocentric prospective study and subjected to anamnesis and biosamples collection (saliva and blood) at hospitalization (acute phase) and 6 months later (remission phase). NGF and BDNF were quantified by ELISA, and biochemical data were related to biostrumental measurements. Increased NGF and BDNF levels were quantified in saliva and serum during the acute phase of SARS-CoV-2 infection (hospitalized patients), and reduced levels were observed in the next 6 months (remission phase), never matching the baseline values. Salivary and circulating data would suggest the possibility of considering sera and saliva as useful matrices for quickly screening neurotrophins, in addition to SARS-CoV2 antigens and RNA. Overall, the findings described herein highlight the importance of NGF and BDNF as dynamic biomarkers for monitoring disease and reinforces the possibility of using saliva and sera for quick, non-invasive COVID-19 screening.

Published
2022

20. sj-pdf-1-lan-10.1177_00236772221111261 - Supplemental material for General and species-specific recommendations for minimal requirements for the use of cephalopods in scientific research

Author

Ponte, Giovanna, Roumbedakis, Katina, Galligioni, Viola, Dickel, Ludovic, Bellanger, Cécile, Pereira, Joao, Vidal, Erica AG, Grigoriou, Panos, Alleva, Enrico, Santucci, Daniela, Gili, Claudia, Botta, Giovanni, Imperadore, Pamela, Tarallo, Andrea, Juergens, Lars, Northrup, Emily, Anderson, David, Aricò, Arianna, De Luca, Marianna, Pieroni, Eleonora Maria, and Fiorito, Graziano

Subjects
70706 Veterinary Medicine, FOS: Veterinary sciences, FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-lan-10.1177_00236772221111261 for General and species-specific recommendations for minimal requirements for the use of cephalopods in scientific research by Giovanna Ponte, Katina Roumbedakis, COST Action FA1301, Viola Galligioni, Ludovic Dickel, Cécile Bellanger, Joao Pereira, Erica AG Vidal, Panos Grigoriou, Enrico Alleva, Daniela Santucci, Claudia Gili, Giovanni Botta, Pamela Imperadore, Andrea Tarallo, Lars Juergens, Emily Northrup, David Anderson, Arianna Aricò, Marianna De Luca, Eleonora Maria Pieroni, Graziano Fiorito in Laboratory Animals

Published
2022
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31. The Oral Health-Related Quality of Life in State Institutionalized Older Adults in Malta.

Author

Santucci, Daniela and Attard, Nikolai

Subjects
OLDER inmates of institutions, HEALTH of older people, QUALITY of life, ORAL diseases, PERIODONTAL pockets, DENTURES, PATIENT satisfaction, MALTESE
Abstract

Purpose: The objective of this study was to determine the oral health-related quality of life in state institutionalized older adults and correlate it to their oral health status. Materials and Methods: A group of 278 older adults (average age: 83.5 ± 6.5 years) from 9 state institutions in Malta was randomly selected. Participants were clinically examined and answered three questionnaires (Oral Health Impact Profile [OHIP-14], Geriatric Oral Health Assessment Index [GOHAI], and Denture Satisfaction). Results: Oral health-related quality of life measurements were significantly associated with pocket depth (OHIP-14 and GOHAI, P < .05); decayed, missing, or filled teeth (OHIP-14 and GOHAI, P < .05); carious teeth (OHIP-14 and GOHAI, P < .05); number of missing teeth (OHIP-14 and GOHAI, P < .05); and maxillary and mandibular dentures (OHIP-14 and GOHAI, P < .0001). Denture satisfaction was associated with denture age (P= .010) and types of prostheses (P< .05). Conclusion: Institutionalized older adults have high levels of oral disease. Although oral health-related quality of life is generally good, those participants with a poorer oral health-related quality of life had significant associations with poor oral health. However, the extent varies with the individual's perception of good health. [ABSTRACT FROM AUTHOR]

Published
2015
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32. Development of a Maltese Version of Oral Health-Associated Questionnaires: OHIP-14, GOHAI, and the Denture Satisfaction Questionnaire.

Author

Santucci, Daniela, Camilleri, Liberato, and Attard, Nikolai

Subjects
HEALTH status indicators, GERIATRIC dentistry, TRANSLATING & interpreting, STATISTICAL sampling, STATISTICAL reliability
Abstract

Purpose: To show the reliability of the Maltese translations of OHIP-14, GOHAI, and the Denture Satisfaction Questionnaire, define the reliability of the responses, and determine the correlation between OHIP-14 and GOHAI. Materials and Methods: The items of the three questionnaires (OHIP-14, GOHAI, and Denture Satisfaction) were translated into Maltese and back into English to compare with the original version. Specific sampling of a population well versed in Maltese and English was carried out to obtain a sample of respondents for each questionnaire. Data were gathered through self-administered questionnaires: first administering the Maltese version and following with the English version 1 week later. Results: Participation rates were high (98%). Cronbach's alpha for all three questionnaires was high (> 0.7), indicating satisfactory test-retest reliability of the instruments. Similarly, the Spearman correlation coefficients for both the English and Maltese versions of OHIP-14 and GOHAI were good (> 0.6). Conclusion: The Maltese versions of OHIP-14, GOHAI, and the Denture Satisfaction Questionnaire can be safely used as a valid alternative to the English versions in studies of patients who are limited in linguistic proficiency. [ABSTRACT FROM AUTHOR]

Published
2014
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34. The Oral Health of Institutionalized Older Adults in Malta.

Author

Santucci, Daniela and Attard, Nikolai

Subjects
INSTITUTIONALIZED persons, OLDER patients, ORAL hygiene, QUALITY of life, DENTAL care, EDENTULOUS mouth, HEALTH
Abstract

Purpose: Studies on the oral health status of institutionalized older adults are less prevalent than those of community-dwelling older adults, as institutionalized older adults tend to be frailer. Poor oral health in older adults has a negative impact on the quality of life and self-confidence of older people and potentially poses a financial burden on both the older adult and society in general. The objective of this study was to assess and compare the oral health status of state institutionalized older adults in Malta with that of their European counterparts. Materials and Methods: A total of 278 older adults with an average age of 83.6 ± 6.5 years from nine state institutions in Malta were randomly selected. Participants were clinically examined for caries, periodontal disease, oral mucosal lesions, and prosthetic status. Results: The oral health status of state institutionalized older adults was poor, with a very low routine dental attendance (29.3%) and, consequently, a high level of treatment need (44.4% of dentate individuals required extractions and 42.1% of dentate individuals required restorations). Only 2% of dentate individuals had healthy periodontal tissues with no clinical attachment loss over 4 mm. Edentulism among state institutionalized older adults stood at 41%. Conclusions: Institutionalized older adults from Malta have a poor oral health status comparable to institutionalized older adults from Europe in general, which poses fiscal and cultural challenges that need to be addressed by the dental community. [ABSTRACT FROM AUTHOR]

Published
2015
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40. Evaluation of Gene, Protein and Neurotrophin Expression in the Brain of Mice Exposed to Space Environment for 91 Days

Author

Santucci, Daniela, primary, Kawano, Fuminori, additional, Ohira, Takashi, additional, Terada, Masahiro, additional, Nakai, Naoya, additional, Francia, Nadia, additional, Alleva, Enrico, additional, Aloe, Luigi, additional, Ochiai, Toshimasa, additional, Cancedda, Ranieri, additional, Goto, Katsumasa, additional, and Ohira, Yoshinobu, additional

Published
2012
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41. The Mice Drawer System (MDS) Experiment and the Space Endurance Record-Breaking Mice

Author

Cancedda, Ranieri, primary, Liu, Yi, additional, Ruggiu, Alessandra, additional, Tavella, Sara, additional, Biticchi, Roberta, additional, Santucci, Daniela, additional, Schwartz, Silvia, additional, Ciparelli, Paolo, additional, Falcetti, Giancarlo, additional, Tenconi, Chiara, additional, Cotronei, Vittorio, additional, and Pignataro, Salvatore, additional

Published
2012
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42. Propagating waves in starling, Sturnus vulgaris, flocks under predation

Author

Procaccini, Andrea, primary, Orlandi, Alberto, additional, Cavagna, Andrea, additional, Giardina, Irene, additional, Zoratto, Francesca, additional, Santucci, Daniela, additional, Chiarotti, Flavia, additional, Hemelrijk, Charlotte K., additional, Alleva, Enrico, additional, Parisi, Giorgio, additional, and Carere, Claudio, additional

Published
2011
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