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1. Hearing loss in Australian First Nations children at 6-monthly assessments from age 12 to 36 months: Secondary outcomes from randomised controlled trials of novel pneumococcal conjugate vaccine schedules

Author

Leach, Amanda Jane, Wilson, Nicole, Arrowsmith, Beth, Beissbarth, Jemima, Mulholland, Kim, Santosham, Mathuram, Torzillo, Paul John, McIntyre, Peter, Smith-Vaughan, Heidi, Skull, Sue A., Oguoma, Victor M., Chatfield, Mark D., Lehmann, Deborah, Brennan-Jones, Christopher G., Binks, Michael J., Licciardi, Paul V., Andrews, Ross M., Snelling, Tom, Krause, Vicki, Carapetis, Jonathan, Chang, Anne B., and Morris, Peter Stanley

Subjects
Australian aborigines -- Health aspects, Infants -- Health aspects, Otitis media -- Complications and side effects, Hearing disorders in children -- Risk factors -- Statistics -- Demographic aspects, Pediatric research, Biological sciences
Abstract

Background In Australian remote communities, First Nations children with otitis media (OM)-related hearing loss are disproportionately at risk of developmental delay and poor school performance, compared to those with normal hearing. Our objective was to compare OM-related hearing loss in children randomised to one of 2 pneumococcal conjugate vaccine (PCV) formulations. Methods and findings In 2 sequential parallel, open-label, randomised controlled trials (the PREVIX trials), eligible infants were first allocated 1:1:1 at age 28 to 38 days to standard or mixed PCV schedules, then at age 12 months to PCV13 (13-valent pneumococcal conjugate vaccine, +P) or PHiD-CV10 (10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine, +S) (1:1). Here, we report prevalence and level of hearing loss outcomes in the +P and +S groups at 6-monthly scheduled assessments from age 12 to 36 months. From March 2013 to September 2018, 261 infants were enrolled and 461 hearing assessments were performed. Prevalence of hearing loss was 78% (25/32) in the +P group and 71% (20/28) in the +S group at baseline, declining to 52% (28/54) in the +P groups and 56% (33/59) in the +S group at age 36 months. At primary endpoint age 18 months, prevalence of moderate (disabling) hearing loss was 21% (9/42) in the +P group and 41% (20/49) in the +S group (difference -19%; (95% confidence interval (CI) [-38, -1], p = 0.07) and prevalence of no hearing loss was 36% (15/42) in the +P group and 16% (8/49) in the +S group (difference 19%; (95% CI [2, 37], p = 0.05). At subsequent time points, prevalence of moderate hearing loss remained lower in the +P group: differences -3%; (95% CI [-23, 18], p = 1.00 at age 24 months), -12%; (95% CI [-30, 6], p = 0.29 at age 30 months), and -9%; (95% CI [-23, 5], p = 0.25 at age 36 months). A major limitation was the small sample size, hence low power to reach statistical significance, thereby reducing confidence in the effect size. Conclusions In this study, we observed a high prevalence and persistence of moderate (disabling) hearing loss throughout early childhood. We found a lower prevalence of moderate hearing loss and correspondingly higher prevalence of no hearing loss in the +P group, which may have substantial benefits for high-risk children, their families, and society, but warrant further investigation. Trial registration ClinicalTrials.gov NCT01735084 and NCT01174849, Author(s): Amanda Jane Leach 1,*, Nicole Wilson 1, Beth Arrowsmith 1,2, Jemima Beissbarth 1, Kim Mulholland 3,4,5, Mathuram Santosham 6,7, Paul John Torzillo 8,9, Peter McIntyre 10,11, Heidi Smith-Vaughan 1, [...]

Published
2024
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4. In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset

Author

Hooli, Shubhada, King, Carina, McCollum, Eric D., Colbourn, Tim, Lufesi, Norman, Mwansambo, Charles, Gregory, Christopher J., Thamthitiwat, Somsak, Cutland, Clare, Madhi, Shabir Ahmed, Nunes, Marta C., Gessner, Bradford D., Hazir, Tabish, Mathew, Joseph L., Addo-Yobo, Emmanuel, Chisaka, Noel, Hassan, Mumtaz, Hibberd, Patricia L., Jeena, Prakash, Lozano, Juan M., MacLeod, William B., Patel, Archana, Thea, Donald M., Nguyen, Ngoc Tuong Vy, Zaman, Syed MA., Ruvinsky, Raul O., Lucero, Marilla, Kartasasmita, Cissy B., Turner, Claudia, Asghar, Rai, Banajeh, Salem, Iqbal, Imran, Maulen-Radovan, Irene, Mino-Leon, Greta, Saha, Samir K., Santosham, Mathuram, Singhi, Sunit, Awasthi, Shally, Bavdekar, Ashish, Chou, Monidarin, Nymadawa, Pagbajabyn, Pape, Jean-William, Paranhos-Baccala, Glaucia, Picot, Valentina Sanchez, Rakoto-Andrianarivelo, Mala, Rouzier, Vanessa, Russomando, Graciela, Sylla, Mariam, Vanhems, Philippe, Wang, Jianwei, Basnet, Sudha, Strand, Tor A., Neuman, Mark I., Arroyo, Luis Martinez, Echavarria, Marcela, Bhatnagar, Shinjini, Wadhwa, Nitya, Lodha, Rakesh, Aneja, Satinder, Gentile, Angela, Chadha, Mandeep, Hirve, Siddhivinayak, O'Grady, Kerry-Ann F., Clara, Alexey W., Rees, Chris A., Campbell, Harry, Nair, Harish, Falconer, Jennifer, Williams, Linda J., Horne, Margaret, Qazi, Shamim A., and Nisar, Yasir Bin

Published
2023
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5. Contributors

Author

Abzug, Mark J., primary, Acharya, Priyamvada, additional, Acosta, Anna M., additional, Ahmed, S. Sohail, additional, Amanna, Ian J., additional, Anderson, Annaliesa S., additional, Asturias, Edwin J., additional, Bachmann, Martin F., additional, Bahl, Sunil, additional, Bailey, Justin R., additional, Baker, Carol J., additional, Balfour, Henry H., additional, Baric, Ralph S., additional, Barnett, Elizabeth D., additional, Barrett, Alan D.T., additional, Belser, Jessica A., additional, Berzofsky, Jay A., additional, Bethony, Jeffrey M., additional, Brewer-Jensen, Paul D., additional, Bubak, Andrew N., additional, Burns, Cara C., additional, Caplan, Arthur L., additional, Cavaleri, Marco, additional, Chandran, Aruna, additional, Cherian, Thomas, additional, Clemens, John D., additional, Cochino, Emil, additional, Cohet, Catherine, additional, Cohn, Amanda, additional, Cortese, Margaret M., additional, Crowcroft, Natasha S., additional, Curtis, Nigel, additional, Damron, F. Heath, additional, Danchin, Margie, additional, Debbink, Kari, additional, Desai, Sachin N., additional, Davis, Emily H., additional, Decker, Michael D., additional, Denison, Mark R., additional, DeStefano, Frank, additional, Douglas, R. Gordon, additional, Dreher-Lesnick, Sheila M., additional, Eberhardt, Christiane S., additional, Edmunds, W. John, additional, Edwards, Caitlin E., additional, Edwards, Kathryn M., additional, Eggers, Rudolf, additional, Ellis, Ronald, additional, Erdman, Dean D., additional, Ertl, Hildegund C.J., additional, Estivariz, Concepcion F., additional, Fine, Paul E.M., additional, Finn, Theresa M., additional, Fisher, Allison M., additional, Fitzwater, Sean Patrick, additional, Freedman, Mark S., additional, Friede, Martin, additional, Friedlander, Arthur M., additional, Frumento, Nicole, additional, Fry, Alicia M., additional, Garçon, Nathalie, additional, Geris, Jennifer M., additional, Gershon, Anne A., additional, Gervier, Regis, additional, Gessner, Bradford D., additional, Gilbert, Peter B., additional, Gomez, Phillip Louis, additional, Ginsberg, Ann M., additional, Grabenstein, John D., additional, Graham, Rachel L., additional, Graham, Barney S., additional, Granoff, Dan M., additional, Gray, Gregory C., additional, Greenberg, David P., additional, Grohskopf, Lisa A., additional, Gruber, Marion F., additional, Guerena, Fernando B., additional, Havelange, Nicolas, additional, Halstead, Scott B., additional, Hanekom, Willem A., additional, Harrison, Lee H., additional, Hawn, Thomas R., additional, Haynes, Barton F., additional, Healy, C. Mary, additional, Hills, Susan L., additional, Hirabayashi, Kuniko, additional, Holmgren, Jan, additional, Hombach, Joachim M., additional, Hotez, Peter Jay, additional, Howe, Barbara J., additional, Hunegnaw, Ruth, additional, Izopet, Jacques, additional, Jamieson, Denise J., additional, Jansen, Kathrin, additional, Jarrahian, Courtney, additional, Johansen, Kari, additional, Kahn, Geoffrey D., additional, Karron, Ruth A., additional, Katz, Jacqueline M., additional, Kennedy, Richard B., additional, Broojerdi, Alireza Khadem, additional, Khetsuriani, Nino, additional, Khudyakov, Yury, additional, Klugman, Keith P., additional, Kocher, Jacob F., additional, Kollaritsch, Herwig, additional, Kotloff, Karen L., additional, Kozarsky, Phyllis E., additional, Kreimer, Aimée R., additional, Kroger, Andrew T., additional, Kwong, Peter D., additional, Lal, Manjari, additional, Levin, Myron J., additional, Levine, Myron M., additional, Lindesmith, Lisa C., additional, Lindstrand, Ann, additional, Ljungman, Per, additional, Lowy, Douglas R., additional, Lundgren, Anna, additional, Lydon, Patrick, additional, Macklin, Grace R., additional, Maeng, Hoyoung M., additional, Mahalingam, Ravi, additional, Malley, Richard, additional, Mallory, Michael L., additional, Marfin, Anthony A., additional, Markowitz, Lauri E., additional, Marshall, CDR Valerie, additional, McCollum, Andrea, additional, Meyer, Sarah, additional, McNamara, Lucy A., additional, Menning, Lisa, additional, Messacar, Kevin, additional, Miller, Mark A., additional, Milutinovic, Pavle, additional, Modlin, John F., additional, Monath, Thomas P., additional, Morabito, Kaitlyn M., additional, Moss, William J., additional, Mulholland, Kim, additional, Mura, Manuela, additional, Musher, Daniel M., additional, Nagel, Maria A., additional, Nair, G. Balakrish, additional, Nelson, Noele P., additional, Netea, Mihai G., additional, Neuzil, Kathleen Maletic, additional, Niemeyer, Christy S., additional, Nohynek, Hanna, additional, Norheim, Gunnstein, additional, Nussbaum, Lauren, additional, O’Brien, Katherine L., additional, O’Leary, Sean, additional, Ockenhouse, Christian, additional, Offit, Paul A., additional, Okwo-Bele, Jean-Marie, additional, Olkhanud, Purevdorj B., additional, Omer, Saad B., additional, Orenstein, Walter A., additional, Oyston, Petra C.F., additional, Parashar, Umesh D., additional, Patel, Manish M., additional, Payne, Daniel C., additional, Pebody, Richard, additional, Pecetta, Simone, additional, Perlman, Stanley, additional, Pierson, Benjamin, additional, Pierson, Theodore C., additional, Pittet, Laure F., additional, Pittman, Phillip R., additional, Plotkin, Stanley A., additional, Plotkin, Susan L., additional, Poland, Gregory A., additional, Pollard, Sir Andrew John, additional, Poovorawan, Yong, additional, Proctor, Richard A., additional, Qadri, Firdausi, additional, Rao, Agam, additional, Rappuoli, Rino, additional, Reef, Susan E., additional, Rogalewicz, Joseph A., additional, Robinson, James Michael, additional, Roesel, Sigrun, additional, Rubin, Steven A., additional, Rupprecht, Charles E., additional, Rutter, Paul, additional, Samant, Vijay B., additional, Sambhara, Suryaprakash, additional, Samies, Nicole L., additional, Santosham, Mathuram, additional, Saunders, Kevin O., additional, Schiller, John T., additional, Schleiss, Mark R., additional, Schuerman, Lode, additional, Schwab, Jennifer, additional, Schwartz, Jason L., additional, Scobie, Heather M., additional, Scott, J. Anthony, additional, Shapiro, Eugene D., additional, Shenoy, Erica S., additional, Shimabukuro, Tom T., additional, Shouval, Daniel, additional, Siegrist, Claire-Anne, additional, Sitrin, Robert D., additional, Skinner, Nicole E., additional, Slifka, Mark K., additional, Sodha, Samir V., additional, Soeters, Heidi M., additional, Solomon, Tom, additional, Speiser, Daniel E., additional, Staples, J. Erin, additional, Steffen, Robert, additional, Stephens, David S., additional, Strebel, Peter M., additional, Subbarao, Kanta, additional, Sullivan, Nancy J., additional, Takashima, Yoshihiro, additional, Tate, Jacqueline E., additional, Tayman, Alice, additional, Telford, Sam R., additional, Thombley, Melisa, additional, Thomsen, Isaac, additional, Tohme, Rania A., additional, Trabold, Malin, additional, El-Turabi, Aadil, additional, Vaughn, David W., additional, Verardi, Raffaello, additional, Vicari, Andrea S., additional, Vidor, Emmanuel J., additional, Villafana, Tonya, additional, Vogt, Matthew R., additional, Walker, Mark J., additional, Walsh, Nick M., additional, Wanlapakorn, Nasamon, additional, Ward, John W., additional, Wassilak, Steven G.F., additional, Watts, Lisa A., additional, Weber, David J., additional, Weiner, David B., additional, Weng, Mark K., additional, Wexler, Deborah L., additional, Wharton, Melinda, additional, Whitley, Richard J., additional, Whitney, Cynthia G., additional, Wiehe, Kevin, additional, Williamson, E. Diane, additional, Wormser, Gary P., additional, Xia, Ningshao, additional, Yildirim, Inci, additional, Zehrung, Darin, additional, and Zweigart, Mark R., additional

Published
2023
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7. Immunogenicity, otitis media, hearing impairment, and nasopharyngeal carriage 6-months after 13-valent or ten-valent booster pneumococcal conjugate vaccines, stratified by mixed priming schedules: PREVIX_COMBO and PREVIX_BOOST randomised controlled trials

Author

Leach, Amanda Jane, Wilson, Nicole, Arrowsmith, Beth, Beissbarth, Jemima, Mulholland, Edward Kim, Santosham, Mathuram, Torzillo, Paul John, McIntyre, Peter, Smith-Vaughan, Heidi, Chatfield, Mark D, Lehmann, Deborah, Binks, Michael, Chang, Anne B, Carapetis, Jonathan, Krause, Vicki, Andrews, Ross, Snelling, Tom, Skull, Sue A, Licciardi, Paul V, Oguoma, Victor M, and Morris, Peter Stanley

Published
2022
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9. Streptococcus pneumoniae serotype 3 population structure in the era of conjugate vaccines, 2001–2018

Author

Cella, Eleonora, primary, Sutcliffe, Catherine G., additional, Grant, Lindsay R., additional, Tso, Carol, additional, Weatherholtz, Robert C., additional, Littlepage, Shea, additional, Becenti, Ladonna, additional, Jubair, Mohammad, additional, Simons, Brenna C., additional, Harker-Jones, Marcella, additional, Reid, Raymond, additional, Yazzie, Del, additional, Santosham, Mathuram, additional, O'Brien, Katherine L., additional, Hammitt, Laura L., additional, and Azarian, Taj, additional

Published
2024
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10. Impact of national introduction of ten-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in Bangladesh: Case-control and time-trend studies

Author

Baqui, Abdullah H., Koffi, Alain K., McCollum, Eric D., Roy, Arunangshu D., Chowdhury, Nabidul H., Rafiqullah, Iftekhar, Ahmed, Zabed B., Mahmud, Arif, Begum, Nazma, Ahmed, Salahuddin, Khanam, Rasheda, Harrison, Meagan, Simmons, Nicole, Hossen, Shakir, Islam, Maksuda, Quaiyum, Abdul, Checkley, William, Santosham, Mathuram, Moulton, Lawrence H., and Saha, Samir K.

Published
2021
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11. Interchangeability, immunogenicity and safety of a combined 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (Synflorix) and 13-valent-PCV (Prevenar13) schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial

Author

Leach, Amanda Jane, Mulholland, Edward Kim, Santosham, Mathuram, Torzillo, Paul John, McIntyre, Peter, Smith-Vaughan, Heidi, Wilson, Nicole, Arrowsmith, Beth, Beissbarth, Jemima, Chatfield, Mark D., Oguoma, Victor M., Licciardi, Paul, Skull, Sue, Andrews, Ross, Carapetis, Jonathan, McDonnell, Joseph, Krause, Vicki, and Morris, Peter Stanley

Published
2021
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13. Setting research priorities to improve global newborn health and prevent stillbirths by 2025.

Author

Yoshida, Sachiyo, Martines, José, Lawn, Joy E, Wall, Stephen, Souza, Joăo Paulo, Rudan, Igor, Cousens, Simon, neonatal health research priority setting group, Aaby, Peter, Adam, Ishag, Adhikari, Ramesh Kant, Ambalavanan, Namasivayam, Arifeen, Shams Ei, Aryal, Dhana Raj, Asiruddin, Sk, Baqui, Abdullah, Barros, Aluisio Jd, Benn, Christine S, Bhandari, Vineet, Bhatnagar, Shinjini, Bhattacharya, Sohinee, Bhutta, Zulfiqar A, Black, Robert E, Blencowe, Hannah, Bose, Carl, Brown, Justin, Bührer, Christoph, Carlo, Wally, Cecatti, Jose Guilherme, Cheung, Po-Yin, Clark, Robert, Colbourn, Tim, Conde-Agudelo, Agustin, Corbett, Erica, Czeizel, Andrew E, Das, Abhik, Day, Louise Tina, Deal, Carolyn, Deorari, Ashok, Dilmen, Uğur, English, Mike, Engmann, Cyril, Esamai, Fabian, Fall, Caroline, Ferriero, Donna M, Gisore, Peter, Hazir, Tabish, Higgins, Rosemary D, Homer, Caroline Se, Hoque, DE, Irgens, Lorentz, Islam, MT, de Graft-Johnson, Joseph, Joshua, Martias Alice, Keenan, William, Khatoon, Soofia, Kieler, Helle, Kramer, Michael S, Lackritz, Eve M, Lavender, Tina, Lawintono, Laurensia, Luhanga, Richard, Marsh, David, McMillan, Douglas, McNamara, Patrick J, Mol, Ben Willem J, Molyneux, Elizabeth, Mukasa, GK, Mutabazi, Miriam, Nacul, Luis Carlos, Nakakeeto, Margaret, Narayanan, Indira, Olusanya, Bolajoko, Osrin, David, Paul, Vinod, Poets, Christian, Reddy, Uma M, Santosham, Mathuram, Sayed, Rubayet, Schlabritz-Loutsevitch, Natalia E, Singhal, Nalini, Smith, Mary Alice, Smith, Peter G, Soofi, Sajid, Spong, Catherine Y, Sultana, Shahin, Tshefu, Antoinette, van Bel, Frank, Gray, Lauren Vestewig, Waiswa, Peter, Wang, Wei, Williams, Sarah LA, Wright, Linda, Zaidi, Anita, Zhang, Yanfeng, Zhong, Nanbert, Zuniga, Isabel, and Bahl, Rajiv

Subjects
neonatal health research priority setting group, Public Health and Health Services
Abstract

BackgroundIn 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.MethodsWe used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.ResultsNine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.ConclusionThese findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Published
2016

15. Otitis media outcomes of a combined 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine and 13-valent pneumococcal conjugate vaccine schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial

Author

Leach, Amanda Jane, Mulholland, Edward Kim, Santosham, Mathuram, Torzillo, Paul John, McIntyre, Peter, Smith-Vaughan, Heidi, Wilson, Nicole, Arrowsmith, Beth, Beissbarth, Jemima, Chatfield, Mark D., Oguoma, Victor M., and Morris, Peter Stanley

Published
2021
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16. Setting research priorities to improve global newborn health and prevent stillbirths by 2025

Author

Yoshida, Sachiyo, Martines, José, Lawn, Joy E, Wall, Stephen, Souza, Joăo Paulo, Rudan, Igor, Cousens, Simon, Aaby, Peter, Adam, Ishag, Adhikari, Ramesh Kant, Ambalavanan, Namasivayam, Arifeen, Shams EI, Aryal, Dhana Raj, Asiruddin, Sk, Baqui, Abdullah, Barros, Aluisio JD, Benn, Christine S, Bhandari, Vineet, Bhatnagar, Shinjini, Bhattacharya, Sohinee, Bhutta, Zulfiqar A, Black, Robert E, Blencowe, Hannah, Bose, Carl, Brown, Justin, Bührer, Christoph, Carlo, Wally, Cecatti, Jose Guilherme, Cheung, Po–Yin, Clark, Robert, Colbourn, Tim, Conde–Agudelo, Agustin, Corbett, Erica, Czeizel, Andrew E, Das, Abhik, Day, Louise Tina, Deal, Carolyn, Deorari, Ashok, Dilmen, Uğur, English, Mike, Engmann, Cyril, Esamai, Fabian, Fall, Caroline, Ferriero, Donna M, Gisore, Peter, Hazir, Tabish, Higgins, Rosemary D, Homer, Caroline SE, Hoque, DE, Irgens, Lorentz, Islam, MT, de Graft–Johnson, Joseph, Joshua, Martias Alice, Keenan, William, Khatoon, Soofia, Kieler, Helle, Kramer, Michael S, Lackritz, Eve M, Lavender, Tina, Lawintono, Laurensia, Luhanga, Richard, Marsh, David, McMillan, Douglas, McNamara, Patrick J, Mol, Ben Willem J, Molyneux, Elizabeth, Mukasa, GK, Mutabazi, Miriam, Nacul, Luis Carlos, Nakakeeto, Margaret, Narayanan, Indira, Olusanya, Bolajoko, Osrin, David, Paul, Vinod, Poets, Christian, Reddy, Uma M, Santosham, Mathuram, Sayed, Rubayet, Schlabritz–Loutsevitch, Natalia E, Singhal, Nalini, Smith, Mary Alice, Smith, Peter G, Soofi, Sajid, Spong, Catherine Y, Sultana, Shahin, Tshefu, Antoinette, van Bel, Frank, Gray, Lauren Vestewig, Waiswa, Peter, Wang, Wei, Williams, Sarah LA, Wright, Linda, Zaidi, Anita, Zhang, Yanfeng, Zhong, Nanbert, Zuniga, Isabel, and Bahl, Rajiv

Subjects
Public Health, Health Sciences, Infant Mortality, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Good Health and Well Being, neonatal health research priority setting group, Public Health and Health Services, Public health
Abstract

BackgroundIn 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.MethodsWe used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.ResultsNine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.ConclusionThese findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Published
2015

20. Streptococcus pneumoniae serotype 3 population structure in the era of conjugate vaccines, 2001-2018

Author

Cella, Eleonora, primary, Sutcliffe, Catherine G, additional, Grant, Lindsay R, additional, Tso, Carol, additional, Weatherholtz, Robert C, additional, Littlepage, Shea, additional, Becenti, Ladonna, additional, Jubair, Mohammad, additional, Simons, Brenna C, additional, Harker-Jones, Marcella, additional, Reid, Raymond, additional, Yazzie, Del, additional, Santosham, Mathuram, additional, O'Brien, Katherine L, additional, Hammitt, Laura L, additional, and Azarian, Taj, additional

Published
2023
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22. Case-control vaccine effectiveness studies: Data collection, analysis and reporting results

Author

Verani, Jennifer R., Baqui, Abdullah H., Broome, Claire V., Cherian, Thomas, Cohen, Cheryl, Farrar, Jennifer L., Feikin, Daniel R., Groome, Michelle J., Hajjeh, Rana A., Johnson, Hope L., Madhi, Shabir A., Mulholland, Kim, O'Brien, Katherine L., Parashar, Umesh D., Patel, Manish M., Rodrigues, Laura C., Santosham, Mathuram, Scott, J. Anthony, Smith, Peter G., Sommerfelt, Halvor, Tate, Jacqueline E., Victor, J. Chris, Whitney, Cynthia G., Zaidi, Anita K., and Zell, Elizabeth R.

Published
2017
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23. Case-control vaccine effectiveness studies: Preparation, design, and enrollment of cases and controls

Author

Verani, Jennifer R., Baqui, Abdullah H., Broome, Claire V., Cherian, Thomas, Cohen, Cheryl, Farrar, Jennifer L., Feikin, Daniel R., Groome, Michelle J., Hajjeh, Rana A., Johnson, Hope L., Madhi, Shabir A., Mulholland, Kim, O'Brien, Katherine L., Parashar, Umesh D., Patel, Manish M., Rodrigues, Laura C., Santosham, Mathuram, Scott, J. Anthony, Smith, Peter G., Sommerfelt, Halvor, Tate, Jacqueline E., Victor, J. Chris, Whitney, Cynthia G., Zaidi, Anita K., and Zell, Elizabeth R.

Published
2017
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25. The need for COVID-19 research in low- and middle-income countries

Author

Gupta, Madhu, Wahl, Brian, Adhikari, Binita, Bar-Zeev, Naor, Bhandari, Sudip, Coria, Alexandra, Erchick, Daniel J., Gupta, Nidhi, Hariyani, Shreya, Kagucia, E. Wangeci, Killewo, Japhet, Limaye, Rupali Jayant, McCollum, Eric D., Pandey, Raghukul, Pomat, William S., Rao, Krishna D., Santosham, Mathuram, Sauer, Molly, Wanyenze, Rhoda K., and Peters, David H.

Published
2020
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26. Considerations for unblinding individual study participants during vaccine trials

Author

Halsey, Neal, primary, Evans, Stephen, additional, Santosham, Mathuram, additional, Hacker, Adam, additional, Edwards, Kathryn M., additional, Chandler, Rebecca E., additional, Dudley, Matthew Z., additional, Dekker, Cornelia L., additional, Al-Abri, Seif, additional, Arora, Narendra, additional, Buttery, Jim, additional, Dodoo, Alex, additional, Eskola, Juhani, additional, Heininger, Ulrich, additional, Jee, Youngmee, additional, Khuri, Najwa, additional, Obaro, Stephen, additional, Orenstein, Walt, additional, Pitisuttithum, Punnee, additional, Safadi, Marco, additional, Whitney, Cynthia G., additional, and Black, Steve, additional

Published
2023
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29. INFECTIOUS DIARRHEA

Author

Fitzwater, Sean, primary, Shet, Anita, additional, Santosham, Mathuram, additional, and Kosek, Margaret, additional

Published
2018
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30. Contributors

Author

Abrignani, Sergio, primary, Ahmed, S. Sohail, additional, Amanna, Ian J., additional, Anderson, Teresa A., additional, Arlett, Peter R., additional, Atkinson, William L., additional, Averhoff, Francisco M., additional, Aylward, R. Bruce, additional, Bachmann, Martin F., additional, Baker, Carol J., additional, Balfour, Henry H., additional, Ballou, W. Ripley, additional, Baric, Ralph S., additional, Barrett, Alan D.T., additional, Barnett, Elizabeth D., additional, Belgharbi, Lahouari, additional, Berinstein, Elliot M., additional, Berinstein, Neil L., additional, Bethony, Jeffrey M., additional, Bogaerts, Hugues, additional, Bot, Adrian, additional, Brachman, Philip S., additional, Bresee, Joseph S., additional, Broojerdi, Alireza Khadem, additional, Caplan, Arthur L., additional, Cavaleri, Marco, additional, Cherian, Thomas, additional, Choi-Sing, Pele, additional, Clemens, John D., additional, Cochi, Stephen L., additional, Cohn, Amanda, additional, Cortese, Capt. Margaret M., additional, Cox, Nancy J., additional, Cutts, Felicity, additional, Dagan, Ron, additional, Dalton, Harry R., additional, Daum, Robert S., additional, Davey, Andrea Sudell, additional, De Francesco, Raffaele, additional, Debbink, Kari, additional, Decker, Michael D., additional, Desai, Sachin N., additional, DeStefano, Frank, additional, Douglas, R. Gordon, additional, Dubischar, Katrin, additional, Edmunds, W. John, additional, Edwards, Kathryn M., additional, Egan, William, additional, Eggers, Rudolf, additional, Ehmann, Falk, additional, Ellis, Ronald W., additional, El-Turabi, Aadil, additional, Erdman, Dean D., additional, Ertl, Hildegund, additional, Fine, Paul E.M., additional, Finn, Theresa M., additional, Fisher, Allison, additional, Friede, Martin, additional, Friedlander, Arthur M., additional, Fry, Alicia M., additional, Garçon, Nathalie, additional, Gastañaduy, Paul A., additional, Gershman, Mark D., additional, Gershon, Anne A., additional, Gessner, Bradford D., additional, Gilbert, Peter, additional, Ginsberg, Ann M., additional, Girard, Marc P., additional, Gomez, Phillip L., additional, Goodson, James L., additional, Goodwin, Robert R., additional, Gordon, Lance K., additional, Grabenstein, John D., additional, Graham, Barney S., additional, Graham, Rachel L., additional, Granoff, Dan M., additional, Gray, Gregory C., additional, Gruber, Marion F., additional, Halstead, Scott B., additional, Hanekom, Willem, additional, Harrison, Lee H., additional, Hawn, Thomas R., additional, Healy, C. Mary, additional, Henderson, Donald A., additional, Hildesheim, Allan, additional, Hills, Susan L., additional, Holmgren, Jan, additional, Hombach, Joachim, additional, Hotez, Peter J., additional, Houghton, Michael, additional, Houston, Avril Melissa, additional, Howe, Barbara J., additional, Izopet, Jacques, additional, Jamieson, Denise J., additional, Jarrahian, Courtney, additional, Johansen, Kari, additional, Karron, Ruth A., additional, Kennedy, Richard B., additional, Kew, Olen M., additional, Khudyakov, Yury, additional, Klein, Michel, additional, Klugman, Keith P., additional, Kocher, Jacob F., additional, Koff, Wayne C., additional, Kollaritsch, Herwig, additional, Kotloff, Karen L., additional, Kozarsky, Phyllis E., additional, Kroger, Andrew T., additional, Kurz, Xavier, additional, Lakdawala, Seema S., additional, Lane, J. Michael, additional, Leigh, Kendra, additional, Levin, Myron J., additional, Levine, Emily Marcus, additional, Levine, Myron M., additional, Lindesmith, Lisa C., additional, Ljungman, Per, additional, Lowy, Douglas R., additional, Luke, Catherine J., additional, Lundgren, Anna, additional, Lydon, Patrick, additional, Malley, Richard, additional, Marin, Mona, additional, Markowitz, Lauri E., additional, Marshall, Lieut. Valerie B., additional, Miller, Mark A., additional, Monath, Thomas P., additional, Moss, William J., additional, Mulholland, Kim, additional, Musher, Daniel M., additional, Nabel, Gary J., additional, Nagarajan, Thirumeni, additional, Nair, GB, additional, Nanduri, Srinivas Acharya, additional, Neddermann, Petra, additional, Nelson, Noele P., additional, Offit, Paul A., additional, Okwo-Bele, Jean-Marie, additional, Omer, Saad B., additional, Orenstein, Walter A., additional, Oyston, Petra C.F., additional, Papania, Mark J., additional, Parashar, Umesh D., additional, Pfeifer, Dina, additional, Pickering, Larry K., additional, Pittman, Phillip R., additional, Ploquin, Aurélie, additional, Plotkin, Stanley A., additional, Plotkin, Susan L., additional, Poland, Gregory A., additional, Pollard, Andrew J., additional, Qadri, Firdausi, additional, Quirk, Mary R., additional, Rao, Raman D.S.V., additional, Rappuoli, Rino, additional, Reef, Susan E., additional, Ridpath, Alison D., additional, Robinson, James M., additional, Rodewald, Lance E., additional, Rodriguez-Hernandez, Carmen A., additional, Roper, Martha H., additional, Rubin, Steven A., additional, Rupprecht, Charles E., additional, Rutala, William A., additional, Salisbury, David, additional, Samant, Vijay B., additional, Sambhara, Suryaprakash, additional, Santosham, Mathuram, additional, Schiller, John T., additional, Schleiss, Mark R., additional, Schuchat, Anne, additional, Schwartz, Jason L., additional, Scobie, Heather M., additional, Scott, J. Anthony, additional, Seward, Jane F., additional, Shouval, Daniel, additional, Siegrist, Claire-Anne, additional, Slifka, Mark K., additional, Sodha, Samir V., additional, Stanberry, Lawrence R., additional, Staples, J. Erin, additional, Steere, Allen C., additional, Steffen, Robert, additional, Strebel, Peter M., additional, Subbarao, Kanta, additional, Sullivan, Nancy J., additional, Sutcliffe, Catherine G., additional, Sutherland, Andrea R., additional, Sutter, Roland W., additional, Thomas, Stephen J., additional, Tiwari, Tejpratap S.P, additional, Tsai, Theodore F., additional, Van Damme, Pierre, additional, Vekemans, Johan, additional, Vidor, Emmanuel, additional, Ward, John W., additional, Wassilak, Steven G.F., additional, Weber, David J., additional, Weiner, David B., additional, Wexler, Deborah L., additional, Wharton, Melinda, additional, Whitney, Cynthia G., additional, Williamson, E. Diane, additional, Wood, David J., additional, Xia, Ningshao, additional, Xu, Zhi Yi, additional, Zanetti, Alessandro, additional, and Zehrung, Darin, additional

Published
2018
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33. Safety and efficacy of alternative antibiotic regimens compared with 7 day injectable procaine benzylpenicillin and gentamicin for outpatient treatment of neonates and young infants with clinical signs of severe infection when referral is not possible: a randomised, open-label, equivalence trial

Author

Baqui, Abdullah H, Saha, Samir K, Ahmed, A S M Nawshad Uddin, Shahidullah, Mohammad, Quasem, Iftekhar, Roth, Daniel E, Samsuzzaman, A K M, Ahmed, Wazir, Tabib, S M Shahnawaz Bin, Mitra, Dipak K, Begum, Nazma, Islam, Maksuda, Mahmud, Arif, Rahman, Mohammad Hefzur, Moin, Mamun Ibne, Mullany, Luke C, Cousens, Simon, El Arifeen, Shams, Wall, Stephen, Brandes, Neal, Santosham, Mathuram, and Black, Robert E

Published
2015
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39. Efficacy of zinc given as an adjunct in the treatment of severe and very severe pneumonia in hospitalized children 2–24 mo of age: a randomized, double-blind, placebo-controlled trial

Author

Wadhwa, Nitya, Chandran, Aruna, Aneja, Satinder, Lodha, Rakesh, Kabra, Sushil K, Chaturvedi, Mona K, Sodhi, Jitender, Fitzwater, Sean P, Chandra, Jagdish, Rath, Bimbadhar, Kainth, Udaypal S, Saini, Savita, Black, Robert E, Santosham, Mathuram, and Bhatnagar, Shinjini

Published
2013
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49. Derivation and validation of a novel risk assessment tool to identify children aged 2–59 months at risk of hospitalised pneumonia-related mortality in 20 countries

Author

Rees, Chris A, primary, Colbourn, Tim, additional, Hooli, Shubhada, additional, King, Carina, additional, Lufesi, Norman, additional, McCollum, Eric D, additional, Mwansambo, Charles, additional, Cutland, Clare, additional, Madhi, Shabir Ahmed, additional, Nunes, Marta, additional, Mathew, Joseph L, additional, Addo-Yobo, Emmanuel, additional, Chisaka, Noel, additional, Hassan, Mumtaz, additional, Hibberd, Patricia L, additional, Jeena, Prakash M, additional, Lozano, Juan M, additional, MacLeod, William B, additional, Patel, Archana, additional, Thea, Donald M, additional, Nguyen, Ngoc Tuong Vy, additional, Kartasasmita, Cissy B, additional, Lucero, Marilla, additional, Awasthi, Shally, additional, Bavdekar, Ashish, additional, Chou, Monidarin, additional, Nymadawa, Pagbajabyn, additional, Pape, Jean-William, additional, Paranhos-Baccala, Glaucia, additional, Picot, Valentina S, additional, Rakoto-Andrianarivelo, Mala, additional, Rouzier, Vanessa, additional, Russomando, Graciela, additional, Sylla, Mariam, additional, Vanhems, Philippe, additional, Wang, Jianwei, additional, Asghar, Rai, additional, Banajeh, Salem, additional, Iqbal, Imran, additional, Maulen-Radovan, Irene, additional, Mino-Leon, Greta, additional, Saha, Samir K, additional, Santosham, Mathuram, additional, Singhi, Sunit, additional, Basnet, Sudha, additional, Strand, Tor A, additional, Bhatnagar, Shinjini, additional, Wadhwa, Nitya, additional, Lodha, Rakesh, additional, Aneja, Satinder, additional, Clara, Alexey W, additional, Campbell, Harry, additional, Nair, Harish, additional, Falconer, Jennifer, additional, Qazi, Shamim A, additional, Nisar, Yasir B, additional, and Neuman, Mark I, additional

Published
2022
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