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222 results on '"Santos‐Briz, Ángel"'

4. Principales tipos de quistes en dermatopatología: Parte 2

Author

Fernández Figueras, María Teresa, Alzoghby-Abi Chaker, Jacques, Fernandez-Parrado, Miriam, García Herrera, Adriana, Garrido, María, Idoate Gastearena, Miguel Ángel, Llamas-Velasco, Mar, Monteagudo, Carlos, Onrubia, José, Pérez Muñoz, Noelia, Ríos-Martín, Juan José, Rodríguez Peralto, José Luis, Rozas Muñoz, Eduardo, Sanmartín, Onofre, Santos-Briz, Ángel, Saus, Carles, Suárez Peñaranda, José Manuel, Velasco Benito, Verónica, Beato Merino, María José, and Fernandez-Flores, Ángel

Published
2024
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5. Principales tipos de quistes en dermatopatología: parte 1

Author

Fernández Figueras, María Teresa, Alzoghby-Abi Chaker, Jacques, Fernandez-Parrado, Miriam, García Herrera, Adriana, Garrido, María, Idoate Gastearena, Miguel Ángel, Llamas-Velasco, Mar, Monteagudo, Carlos, Onrubia, José, Pérez Muñoz, Noelia, Ríos-Martín, Juan José, Rodríguez Peralto, José Luis, Rozas Muñoz, Eduardo, Sanmartín, Onofre, Santos-Briz, Ángel, Saus, Carles, Suárez Peñaranda, José Manuel, Velasco Benito, Verónica, Beato Merino, María José, and Fernandez-Flores, Ángel

Published
2024
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7. Cutaneous collagenous vasculopathy: papular form

Author

Conde-Ferreirós, Alberto, Roncero-Riesco, Mónica, Cañueto, Javier, Román-Curto, Concepción, and Santos-Briz, Ángel

Subjects
cutaneous collagenous vasculopathy, collagen IV, microangiopathy, cutaneous telangiectasias
Abstract

Cutaneous collagenous vasculopathy is a rare clinicopathological entity, first described in 2000. Cutaneous collagenous vasculopathy has been considered a form of microangiopathy of superficial dermal vessels and produce lesions that appear as telangiectasia. We present a patient with histopathologic features of cutaneous collagenous vasculopathy and scattered erythematous papules on the trunk with a striking dermatoscopic finding. We propose the term of 'cutaneous papular collagenous vasculopathy' as a new clinical manifestation of this disease.

Published
2019

8. Clinical and pathological features of Merkel cell carcinoma: A 4-year follow-up observational retrospective study in Spain

Author

Ríos-Martín, Juan José, Rodriguez-Salas, Nuria, Vázquez-Doval, Francisco Javier, Llombart, Beatriz, Rojas-Ferrer, Nohelia, González-Vela, M. Carmen, Zulueta, Teresa, Monteagudo, Carlos, Aneiros-Fernández, José, Beato, María José, Carrillo, Rosario, Silva-Carmona, Mary Yohana, Ayala, María, Gallego, Elena, Rodríguez-Peralto, José Luís, Fraga-Fernández, Javier, Fernández-Figueras, María Teresa, Barranco, Carlos, Córdoba, Alicia, Sanz-Zorrilla, Alicia, Ferrer, Berta, Fúnez, Rafael, Santonja, Carlos, Saus, Carlos, Idoate, Miguel Angel, Santos-Briz, Angel, Onrubia, José, Pinedo, Fernando, and de las Peñas, Ramón

Published
2022
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11. TMeB score may improve risk stratification of high‐risk cutaneous squamous cell carcinoma and guide management of patients: A pilot study

Author

Cañueto, Javier, Corchete‐Sánchez, Luis Antonio, Schmults, Chrysalyne D., García‐Sancha, Natalia, Corchado‐Cobos, Roberto, Mendiburu‐Eliçabe, Marina, Santos‐Briz, Ángel, Cardeñoso‐Álvarez, Esther, Pérez‐Losada, Jesús, Román‐Curto, Concepción, Ruiz, Emily S., Cañueto, Javier, Corchete‐Sánchez, Luis Antonio, Schmults, Chrysalyne D., García‐Sancha, Natalia, Corchado‐Cobos, Roberto, Mendiburu‐Eliçabe, Marina, Santos‐Briz, Ángel, Cardeñoso‐Álvarez, Esther, Pérez‐Losada, Jesús, Román‐Curto, Concepción, and Ruiz, Emily S.

Abstract

Risk factors of poor prognosis in cutaneous squamous cell carcinoma (CSCC) include large tumour diameter, large-calibre perineural invasion, deep tumour invasion, and poorly differentiated histology.1 However, other risk factors likely play a role in tumour aggressiveness.2 Low peritumoural inflammation3 and desmoplasia4 (features of the tumour microenvironment [TMe]) and tumour budding5, 6 (TB) have been associated with poor prognosis in CSCC in a few studies. The present study examines whether these three attributes (considered collectively based on a risk score) improve CSCC risk stratification. The study was approved by the University Hospital of Salamanca's Ethics Board and complied with STROBE recommendations. In total, 124 high-risk CSCCs (HR-CSCCs), defined as T3/T4-AJCC8, treated with clear-margin surgical excision were included. Cases with microscopical residual disease, bone involvement, or lost in follow-up were excluded. Low peritumoural inflammation, the presence of desmoplasia,4 and the presence of tumour budding (TB)5, 6 were utilized to derive the tumoural microenvironment and budding (TMeB) risk score: 1, no risk factors present; 2, one or two risk factors present; and 3, all three risk factors present. Peritumoural inflammation was defined as brisk/intense (peritumoural continuous), non-brisk/moderate (peritumoural discontinuous), scarce (dotted inflammatory cells), and absent, and it was dichotomized to distinguish low peritumoural inflammation (absent, scarce) from high (brisk, non-brisk). Desmoplasia was present when at least one-third of the tumour showed desmoplastic stroma.4 Tumour budding was defined by isolated tumour cells, or ≥4 groups of ≥5 tumour cells along the invasion front5, 6 (best observed at magnification >100×; Figure 1). Disease-free and event-free survival were assessed using R (v.3.4.1) packages survival (v.2.41-3), survminer (v.0.4.2) and cmprsk (v.2.2_7). Primary endpoints were local recurrence (LR), nodal metastasis (NM), Depto. de Estadística e Investigación Operativa, Fac. de Farmacia, TRUE, pub

Published
2024

12. Artificial intelligence-empowered cellular morphometric risk score improves prognostic stratification of cutaneous squamous cell carcinoma.

Author

Pérez-Baena, Manuel J, Mao, Jian-Hua, Pérez-Losada, Jesús, Santos-Briz, Ángel, Chang, Hang, and Cañueto, Javier

Subjects
DISEASE risk factors, SQUAMOUS cell carcinoma, WOMEN'S hospitals, ARTIFICIAL intelligence, MACHINE learning
Abstract

Background Risk stratification of cutaneous squamous cell carcinoma (cSCC) is essential for managing patients. Objectives To determine if artificial intelligence and machine learning might help to stratify patients with cSCC by risk using more than solely clinical and histopathological factors. Methods We retrieved a retrospective cohort of 104 patients whose cSCCs had been excised with clear margins. Clinical and histopathological risk factors were evaluated. Haematoxylin and eosin-stained slides were scanned and analysed by an algorithm based on the stacked predictive sparse decomposition technique. Cellular morphometric biomarkers (CMBs) were identified via machine learning and used to derive a cellular morphometric risk score (CMRS) that classified cSCCs into clusters of differential prognoses. Concordance analysis, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were calculated and compared with results obtained with the Brigham and Women's Hospital (BWH) staging system. The performance of the combination of the BWH staging system and the CMBs was also analysed. Results There were no differences among the CMRS groups in terms of clinical and histopathological risk factors and T-stage assignment, but there were significant differences in prognosis. Combining the CMRS with BWH staging systems increased distinctiveness and improved prognostic performance. C-indices were 0.91 local recurrence and 0.91 for nodal metastasis when combining the two approaches. The NPV was 94.41% and 96.00%, the PPV was 36.36% and 41.67%, and accuracy reached 86.75% and 89.16%, respectively, with the combined approach. Conclusions CMRS is helpful for cSCC risk stratification beyond classic clinical and histopathological risk features. Combining the information from the CMRS and the BWH staging system offers outstanding prognostic performance for patients with high-risk cSCC. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Pancreatic panniculitis revisited: A series of 34 patients

Author

Seguí, Mireia, primary, Rodríguez‐Jiménez, Pedro, additional, Fraga, Javier, additional, Navas, José, additional, Ríos, Juan José, additional, Revilla, David, additional, Santos‐Briz, Ángel, additional, Lluch, Juan José, additional, Fernández Figueras, María Teresa, additional, Luque, Mar, additional, and Llamas Velasco, Mar, additional

Published
2023
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16. Primary Cutaneous Marginal Zone Lymphoproliferative Disorder of Donor Origin after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Bejarano, Lía, Sayagués, José María, Alcoceba, Miguel, Balanzategui, Ana, López-Corral, L., Cañueto, Javier, Santos-Briz, Ángel, Bejarano, Lía, Sayagués, José María, Alcoceba, Miguel, Balanzategui, Ana, López-Corral, L., Cañueto, Javier, and Santos-Briz, Ángel

Abstract

Primary cutaneous posttransplant lymphoproliferative disorders (PTLDs) after allogeneic hematopoietic stem cell transplant (allo-HSCT) are exceedingly rare, with only 6 published cases, all of them consisting in T-cell neoplasms. In this report, we present for the first time a donor-derived B-cell PTLD consisting in a primary, cutaneous, B-cell, marginal zone, lymphoproliferative disorder (PCMZLPD). The patient, a 37-year-old woman with a history of Hodgkin lymphoma received an allo-HSCT from her healthy, matched, related father, achieving complete host chimerism in the bone marrow and peripheral blood. However, 8 years after the allo-HSCT, she presented asymptomatic skin lesions consisting in oval, well-defined, slightly raised erythematous plaques, located on the arms, trunk, and legs. Skin biopsies of 2 lesions demonstrated a class-switched IgG+, EBV-, PCMZLPD, showing kappa light chain restriction and monoclonal rearrangement of the IgH gene. Microsatellite genotyping and 2-color fluorescence in situ hybridization (X and Y chromosomes) confirmed that the origin of the neoplastic cells was the donor graft. The lesions showed an indolent behavior, good response to topical corticosteroids, and no need for systemic treatment. Our case broadens the spectrum of PTLD, a diverse group of lymphoid and/or plasmacytic proliferations with variable clinical presentations and histopathological features.

Published
2023

17. TMeB score may improve risk stratification of high-risk cutaneous squamous cell carcinoma and guide management of patients: A pilot study

Author

Junta de Castilla y León, Instituto de Salud Carlos III, European Commission, Cañueto, Javier, Corchete, Luis A., Schmults, Chrysalyne D., García-Sancha, Natalia, Corchado Cobos, Roberto, Mendiburu-Eliçabe, Marina, Santos-Briz, Ángel, Cardeñoso-Álvarez, Ester, Pérez-Losada, J., Román-Curto, Concépción, Ruiz, Emily S., Junta de Castilla y León, Instituto de Salud Carlos III, European Commission, Cañueto, Javier, Corchete, Luis A., Schmults, Chrysalyne D., García-Sancha, Natalia, Corchado Cobos, Roberto, Mendiburu-Eliçabe, Marina, Santos-Briz, Ángel, Cardeñoso-Álvarez, Ester, Pérez-Losada, J., Román-Curto, Concépción, and Ruiz, Emily S.

Published
2023

19. TMeB score may improve risk stratification of high‐risk cutaneous squamous cell carcinoma and guide management of patients: A pilot study

Author

Cañueto, Javier, primary, Corchete‐Sánchez, Luis Antonio, additional, Schmults, Chrysalyne D., additional, García‐Sancha, Natalia, additional, Corchado‐Cobos, Roberto, additional, Mendiburu‐Eliçabe, Marina, additional, Santos‐Briz, Ángel, additional, Cardeñoso‐Álvarez, Esther, additional, Pérez‐Losada, Jesús, additional, Román‐Curto, Concepción, additional, and Ruiz, Emily S., additional

Published
2022
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21. Recomendaciones para la determinación de biomarcadores en el melanoma metastásico. Consenso Nacional de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Oncología Médica

Author

Rodríguez-Peralto, José Luis, Espinosa, Enrique, Ríos-Martín, Juan José, Berrocal, Alfonso, Lozano, María Dolores, Arance, Ana, Santos-Briz, Angel, López-Martín, José Antonio, Fernández-Figueras, María Teresa, and Martín-Algarra, Salvador

Published
2014
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24. Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case-control study

Author

Instituto de Salud Carlos III, Conde-Ferreirós, Alberto, Moyano-Bueno, David, Santos-Briz, Ángel, Revelles, Leonor, Revilla, David, Becerril, Sara, Román-Curto, Concépción, Cañueto, Javier, Instituto de Salud Carlos III, Conde-Ferreirós, Alberto, Moyano-Bueno, David, Santos-Briz, Ángel, Revelles, Leonor, Revilla, David, Becerril, Sara, Román-Curto, Concépción, and Cañueto, Javier

Abstract

[Background]: Acantholytic cutaneous squamous cell carcinomas (aCSCCs) have been classically considered as a high-risk variant of CSCC. However, more recent studies show that aCSCC does not confer more aggressiveness. This study aims to establish whether the prognosis of the aCSCC is worse than that of the non-acantholytic (naCSCC) or not. [Methods]: Retrospective case-control study with 50 aCSCCs and 50 naCSCCs. For each aCSCC, an naCSCC with similar high-risk features to the aCSCC but with no acantholysis was selected. Prognosis between both groups was compared. [Results]: The mean age was 86 years (SD 9.61). Sixty-one patients were men. Thirty-nine CSCCs were located in high-risk head and neck areas. Twenty CSCCs exhibited a poor degree of differentiation, and 36 showed an infiltrative growth pattern. The tumor diameter was 18.71 mm (interquartile range, IQR 35), and the tumor thickness was 6.72 mm (IQR 15.50). Twelve CSCCs exhibited perineural infiltration, and eight CSCCs exhibited invasion beyond the subcutaneous fat. Positive margins after excision of the tumor in 22 aCSCCs vs eight naCSCCs (P < 0.02). Nineteen poor-prognosis events were observed (local recurrence, lymph node metastasis, and death from CSCC). However, no differences were observed between both groups when comparing poor-prognosis events. [Conclusion]: The proportion of unfavorable events is similar in aCSCC and naCSCC. The acantholytic histopathological subtype is not associated with a poorer prognosis than the non-acantholytic CSCC in our cohort.

Published
2022

28. TMeB score may improve risk stratification of high-risk cutaneous squamous cell carcinoma and guide management of patients: A pilot study.

Author

Cañueto, Javier, Corchete-Sánchez, Luis Antonio, Schmults, Chrysalyne D., García-Sancha, Natalia, Corchado-Cobos, Roberto, Mendiburu-Eliçabe, Marina, Santos-Briz, Ángel, Cardeñoso-Álvarez, Esther, Pérez-Losada, Jesús, Román-Curto, Concepción, and Ruiz, Emily S.

Subjects
SQUAMOUS cell carcinoma, PILOT projects
Published
2023
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32. Identification of a characteristic copy number alteration profile by high-resolution single nucleotide polymorphism arrays associated with metastatic sporadic colorectal cancer

Author

González-González, María, Fontanillo, Celia, Abad, María M., Gutiérrez, María L., Mota, Ines, Bengoechea, Oscar, Santos-Briz, Ángel, Blanco, Oscar, Fonseca, Emilio, Ciudad, Juana, Fuentes, Manuel, De Las Rivas, Javier, Alcazar, José A., García, Jacinto, Muñoz-Bellvis, Luís, Orfao, Alberto, and Sayagués, José M.

Published
2014
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34. Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case‐control study

Author

Conde‐Ferreirós, Alberto, primary, Moyano‐Bueno, David, additional, Santos‐Briz, Ángel, additional, Revelles‐Peñas, Leonor, additional, Revilla‐Nebreda, David, additional, Becerril‐Andrés, Sara, additional, Román‐Curto, Concepción, additional, and Cañueto, Javier, additional

Published
2021
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35. Patterns of incidental perineural invasion and prognosis in cutaneous squamous cell carcinoma: A multicenter, retrospective cohort study

Author

Instituto de Salud Carlos III, European Commission, Junta de Castilla y León, Conde-Ferreirós, Alberto, Corchete, Luis A., Jaka, Ane, Santos-Briz, Ángel, Fuente, María José, Posada, Rodolfo, Pons, Laura, Podlipnik, Sebastián, Pujol, Ramón M., Román-Curto, Concépción, Toll, Agustí, Cañueto, Javier, Instituto de Salud Carlos III, European Commission, Junta de Castilla y León, Conde-Ferreirós, Alberto, Corchete, Luis A., Jaka, Ane, Santos-Briz, Ángel, Fuente, María José, Posada, Rodolfo, Pons, Laura, Podlipnik, Sebastián, Pujol, Ramón M., Román-Curto, Concépción, Toll, Agustí, and Cañueto, Javier

Abstract

To the Editor: Perineural invasion (PNI) is rare and usually incidental in cutaneous squamous cell carcinoma (SCC), with an incidence of 2.5% to 14%.1 Incidental PNI is associated with poor prognosis in cutaneous SCC,2 and some evidence suggests its outcome differs, depending on the PNI pattern. We evaluated patterns of incidental PNI, using a multicenter retrospective cohort of 140 cutaneous SCCs with incidental PNI to determine the influence of nerve involvement on cutaneous SCC prognosis.

Published
2021

36. TERT promoter mutation in sebaceous neoplasms

Author

Muñoz-Jiménez, María-Teresa, primary, Blanco, Leyla, additional, Ruano, Yolanda, additional, Carrillo, Rosario, additional, Santos-Briz, Ángel, additional, Riveiro-Falkenbach, Erika, additional, Requena, Luis, additional, Kutzner, Heinz, additional, Garrido, María Concepción, additional, and Rodríguez-Peralto, José-Luis, additional

Published
2021
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43. Indeterminate Dendritic Cell Tumor as Cutaneous Involvement of Chronic Myelomonocytic Leukemia Successfully Treated With Phototherapy

Author

Santos-Briz, Ángel, Medina-Miguelañez, Mario, Moyano-Bueno, David, Viñolas-Cuadros, Alex, Martínez Martínez, Teresa, Izquierdo, Marta, García-Sánchez, María S., Santos-Briz, Ángel, Medina-Miguelañez, Mario, Moyano-Bueno, David, Viñolas-Cuadros, Alex, Martínez Martínez, Teresa, Izquierdo, Marta, and García-Sánchez, María S.

Abstract

Indeterminate dendritic cell tumor (IDCT) is a rare disease composed of so-called indeterminate cells, a dendritic cell subset displaying histological and some ultrastructural and immunophenotypic features of Langerhans cells, but lacking Birbeck granules. We report a case of cutaneous IDCT occurring in a patient with chronic myelomonocytic leukemia (CMML) successfully treated with UV-A phototherapy. Next-generation sequencing studies of the CMML demonstrated mutations in TET2, ASXL1, and ZRS2 genes, also detected in the IDCT, demonstrating a clonal relationship between both tumors and confirming IDCT as a specific subtype in the spectrum of CMML-related cutaneous lesions.

Published
2020

44. Intratumoral Patterns of Clonal Evolution in Meningiomas as Defined by Multicolor Interphase Fluorescence in Situ Hybridization (FISH) : Is There a Relationship between Histopathologically Benign and Atypical/Anaplastic Lesions?

Author

Sayagués, José María, Tabernero, María Dolores, Maíllo, Angel, Espinosa, Ana, Rasillo, Ana, Díaz, Pedro, Ciudad, Juana, López, Antonio, Merino, Marta, Gonçalves, Jesús María, Santos-Briz, Angel, Morales, Francisco, and Orfao, Alberto

Published
2004
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45. Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case‐control study.

Author

Conde‐Ferreirós, Alberto, Moyano‐Bueno, David, Santos‐Briz, Ángel, Revelles‐Peñas, Leonor, Revilla‐Nebreda, David, Becerril‐Andrés, Sara, Román‐Curto, Concepción, and Cañueto, Javier

Subjects
SQUAMOUS cell carcinoma, CELL analysis, CASE-control method, LYMPHATIC metastasis, HISTOPATHOLOGY
Abstract

Background: Acantholytic cutaneous squamous cell carcinomas (aCSCCs) have been classically considered as a high‐risk variant of CSCC. However, more recent studies show that aCSCC does not confer more aggressiveness. This study aims to establish whether the prognosis of the aCSCC is worse than that of the non‐acantholytic (naCSCC) or not. Methods: Retrospective case‐control study with 50 aCSCCs and 50 naCSCCs. For each aCSCC, an naCSCC with similar high‐risk features to the aCSCC but with no acantholysis was selected. Prognosis between both groups was compared. Results: The mean age was 86 years (SD 9.61). Sixty‐one patients were men. Thirty‐nine CSCCs were located in high‐risk head and neck areas. Twenty CSCCs exhibited a poor degree of differentiation, and 36 showed an infiltrative growth pattern. The tumor diameter was 18.71 mm (interquartile range, IQR 35), and the tumor thickness was 6.72 mm (IQR 15.50). Twelve CSCCs exhibited perineural infiltration, and eight CSCCs exhibited invasion beyond the subcutaneous fat. Positive margins after excision of the tumor in 22 aCSCCs vs eight naCSCCs (P < 0.02). Nineteen poor‐prognosis events were observed (local recurrence, lymph node metastasis, and death from CSCC). However, no differences were observed between both groups when comparing poor‐prognosis events. Conclusion: The proportion of unfavorable events is similar in aCSCC and naCSCC. The acantholytic histopathological subtype is not associated with a poorer prognosis than the non‐acantholytic CSCC in our cohort. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Additional file 1: Figures S1-S4. of Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

Author

Mª Herrero-Sánchez, Rodríguez-Serrano, Concepción, Almeida, Julia, Segundo, Laura San, Inogés, Susana, Santos-Briz, Ángel, García-Briñón, Jesús, Corchete, Luis, Miguel, Jesús San, Cañizo, Consuelo Del, and Blanco, Belén

Abstract

Figure S1. Effect of BKM120 and BEZ235 on the percentage of central memory, effector memory, and effector/TEMRA T cells. Percentage of central memory, effector memory and effector/TEMRA cells among CD4+ and CD8+ cells unstimulated or stimulated in the presence of different concentrations of BKM120 or BEZ235. Mean ± SEM of five different experiments. # p

Published
2016
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