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2. Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, Mooyaart, Jarl E., Devillier, Raynier, Koc, Yener, Vydra, Jan, Castagna, Luca, Gülbas, Zafer, Martin, José Diez, Araujo, Mercedes Colorado, Kulagin, Alexander, Arat, Mutlu, Arroyo, Concepcion Herrera, Martelli, Maria Paola, Di Ianni, Mauro, Hoogenboom, Jorinde D., de Wreede, Liesbeth C., Ruggeri, Annalisa, and Chabannon, Christian

Published
2023
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3. Correction: Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, Mooyaart, Jarl E., Devillier, Raynier, Koc, Yener, Vydra, Jan, Castagna, Luca, Gülbas, Zafer, Martin, José Diez, Araujo, Mercedes Colorado, Kulagin, Alexander, Arat, Mutlu, Arroyo, Concepcion Herrera, Martelli, Maria Paola, Di Ianni, Mauro, Hoogenboom, Jorinde D., de Wreede, Liesbeth C., Ruggeri, Annalisa, and Chabannon, Christian

Published
2023
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5. Matched unrelated donor transplantation versus haploidentical transplantation with post-transplant cyclophosphamide in children with acute myeloid leukemia: a PDWP-EBMT study

Author

Ruggeri, Annalisa, primary, Santoro, Nicole, additional, Galimard, Jacques-Emmanuel, additional, Kalwak, Krzysztof, additional, Algeri, Mattia, additional, Zubarovskaya, Ludmila, additional, Czyzewski, Krzysztof, additional, Skorobogatova, Elena, additional, Sedlacek, Petr, additional, Besley, Caroline, additional, Balduzzi, Adriana, additional, Bertrand, Yves, additional, Peristeri, Julia, additional, Fagioli, Franca, additional, Ifversen, Mariane, additional, Gozdzik, Jolanta, additional, Peters, Christina, additional, Versluijs, Birgitta, additional, Biffi, Alessandra, additional, Prete, Arcangelo, additional, Faraci, Maura, additional, Ghemlas, Ibrahim, additional, Bodova, Ivana, additional, Aleinikova, Olga, additional, Dalissier, Arnaud, additional, Rocha, Vanderson, additional, and Corbacioglu, Selim, additional

Published
2024
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6. Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation

Author

Di Ianni, Mauro, primary, Liberatore, Carmine, additional, Santoro, Nicole, additional, Ranalli, Paola, additional, Guardalupi, Francesco, additional, Corradi, Giulia, additional, Villanova, Ida, additional, Di Francesco, Barbara, additional, Lattanzio, Stefano, additional, Passeri, Cecilia, additional, Lanuti, Paola, additional, and Accorsi, Patrizia, additional

Published
2023
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7. Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation.

Author

Di Ianni, Mauro, Liberatore, Carmine, Santoro, Nicole, Ranalli, Paola, Guardalupi, Francesco, Corradi, Giulia, Villanova, Ida, Di Francesco, Barbara, Lattanzio, Stefano, Passeri, Cecilia, Lanuti, Paola, and Accorsi, Patrizia

Subjects
REGULATORY T cells, SUICIDE, CELLULAR therapy, GENE therapy, BRAIN death
Abstract

GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant setting. This may be possible through continuous improvement of cell therapy techniques. In this review, current cell therapies are taken into consideration, which are based on the use of TCR alpha/beta depletion, CD45RA depletion, T regulatory cell enrichment, NK-cell-based immunotherapies, and suicide gene therapies in order to prevent GvHD and maximally amplify the GvL effect in the setting of haploidentical transplantation. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Correction: Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, primary, Mooyaart, Jarl E., additional, Devillier, Raynier, additional, Koc, Yener, additional, Vydra, Jan, additional, Castagna, Luca, additional, Gülbas, Zafer, additional, Martin, José Diez, additional, Araujo, Mercedes Colorado, additional, Kulagin, Alexander, additional, Arat, Mutlu, additional, Arroyo, Concepcion Herrera, additional, Martelli, Maria Paola, additional, Di Ianni, Mauro, additional, Hoogenboom, Jorinde D., additional, de Wreede, Liesbeth C., additional, Ruggeri, Annalisa, additional, and Chabannon, Christian, additional

Published
2022
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10. Unmanipulated haploidentical in comparison with matched unrelated donor stem cell transplantation in patients 60 years and older with acute myeloid leukemia: a comparative study on behalf of the ALWP of the EBMT

Author

Santoro, Nicole, Labopin, Myriam, Giannotti, Federica, Ehninger, Gerard, Niederwieser, Dietger, Brecht, Arne, Stelljes, Matthias, Kröger, Nicolaus, Einsele, Herman, Eder, Matthias, Hallek, Michael, Glass, Bertram, Finke, Jürgen, Ciceri, Fabio, Mohty, Mohamad, Ruggeri, Annalisa, and Nagler, Arnon

Published
2018
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11. Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Author

Santoro, Nicole, primary, Mooyaart, Jarl E., additional, Devillier, Raynier, additional, Koc, Yener, additional, Vydra, Jan, additional, Castagna, Luca, additional, Gülbas, Zafer, additional, Martin, José Diez, additional, Araujo, Mercedes Colorado, additional, Kulagin, Alexander, additional, Arat, Mutlu, additional, Arroyo, Concepcion Herrera, additional, Martelli, Maria Paola, additional, Di Ianni, Mauro, additional, Hoogenboom, Jorinde D., additional, de Wreede, Liesbeth C., additional, Ruggeri, Annalisa, additional, and Chabannon, Christian, additional

Published
2022
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12. DONOR Lymphocyte Infusions after Haploidentical STEM Cell Transplantation with Ptcy: A Study on Behalf of the Ctiwp of the EBMT

Author

Santoro, Nicole, primary, Mauff, Katya, additional, Devillier, Raynier, additional, Castagna, Luca, additional, Gülbas, Zafer, additional, Diez-Martin, José Luis, additional, Bermúdez, Arancha, additional, Arroyo, Concepcion Herrera, additional, Deconinck, Eric, additional, Sierra, Jorge, additional, Abecasis, Manuel, additional, Ozdogu, Hakan, additional, Mico, Maria Caterina, additional, Rocha, Vanderson, additional, Guyotat, Denis, additional, Chalandon, Yves, additional, Forcade, Edouard, additional, Martin, Hans, additional, Saccardi, Riccardo, additional, Giebel, Sebastian, additional, Di Ianni, Mauro, additional, Hoogenboom, Jorinde, additional, de Wreede, Liesbeth C, additional, Ruggeri, Annalisa, additional, and Chabannon, Christian, additional

Published
2021
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14. 220 - DONOR Lymphocyte Infusions after Haploidentical STEM Cell Transplantation with Ptcy: A Study on Behalf of the Ctiwp of the EBMT

Author

Santoro, Nicole, Mauff, Katya, Devillier, Raynier, Castagna, Luca, Gülbas, Zafer, Diez-Martin, José Luis, Bermúdez, Arancha, Arroyo, Concepcion Herrera, Deconinck, Eric, Sierra, Jorge, Abecasis, Manuel, Ozdogu, Hakan, Mico, Maria Caterina, Rocha, Vanderson, Guyotat, Denis, Chalandon, Yves, Forcade, Edouard, Martin, Hans, Saccardi, Riccardo, Giebel, Sebastian, Di Ianni, Mauro, Hoogenboom, Jorinde, de Wreede, Liesbeth C, Ruggeri, Annalisa, and Chabannon, Christian

Published
2021
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15. Impact of conditioning intensity on outcomes of haploidentical stem cell transplantation for patients with acute myeloid leukemia 45 years of age and over

Author

Santoro, Nicole, primary, Labopin, Myriam, additional, Ciceri, Fabio, additional, Van Lint, Maria Teresa, additional, Nasso, Daniela, additional, Blaise, Didier, additional, Arcese, William, additional, Tischer, Johanna, additional, Bruno, Benedetto, additional, Ehninger, Gerhard, additional, Koc, Yener, additional, Santarone, Stella, additional, Huang, Xiao‐Jun, additional, Savani, Bipin N., additional, Mohty, Mohamad, additional, Ruggeri, Annalisa, additional, and Nagler, Arnon, additional

Published
2019
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16. The Optimal Alternative Donor Transplant for Pediatric Patients with Acute Leukemia: A Comparison between Alfa-Beta T-Cell and B-Cell Depleted Haplo-SCT and UCBT

Author

Locatelli, Franco, primary, Labopin, Myriam, additional, Santoro, Nicole, additional, Dalle, Jean-Hugues, additional, Al-Seraihy, Amal, additional, Volt, Fernanda, additional, Maschan, Mikhail, additional, Jubert, Charlotte, additional, Zecca, Marco, additional, Petersen, Eefke J., additional, Díaz Pérez, Miguel Ángel, additional, Michel, Gerard, additional, Skorobogatova, Elena, additional, Díaz de Heredia, Cristina, additional, OBrien, Tracey, additional, Kenzey, Chantal, additional, Rocha, Vanderson, additional, Gluckman, Eliane, additional, Bader, Peter, additional, and Ruggeri, Annalisa, additional

Published
2018
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17. Additional file 1: Table S1. of Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

Author

Santoro, Nicole, Ruggeri, Annalisa, Labopin, Myriam, Bacigalupo, Andrea, Ciceri, Fabio, Gülbaş, Zafer, Huang, He, Afanasyev, Boris, Arcese, William, Depei Wu, Koc, Yener, Tischer, Johanna, Santarone, Stella, Giebel, Sebastian, Mohty, Mohamad, and Nagler, Arnon

Subjects
surgical procedures, operative, immune system diseases, chemical and pharmacologic phenomena
Abstract

Patient characteristics according to GVHD prophylaxis. (DOCX 19 kb)

Published
2017
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18. Additional file 2: Figure S1. of Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

Author

Santoro, Nicole, Ruggeri, Annalisa, Labopin, Myriam, Bacigalupo, Andrea, Ciceri, Fabio, Gülbaş, Zafer, Huang, He, Afanasyev, Boris, Arcese, William, Depei Wu, Koc, Yener, Tischer, Johanna, Santarone, Stella, Giebel, Sebastian, Mohty, Mohamad, and Nagler, Arnon

Subjects
surgical procedures, operative, immune system diseases, chemical and pharmacologic phenomena
Abstract

Acute and chronic GVHD according to stem cell source. (DOCX 104 kb)

Published
2017
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19. Additional file 3: Table S2. of Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

Author

Santoro, Nicole, Ruggeri, Annalisa, Labopin, Myriam, Bacigalupo, Andrea, Ciceri, Fabio, Gülbaş, Zafer, Huang, He, Afanasyev, Boris, Arcese, William, Depei Wu, Koc, Yener, Tischer, Johanna, Santarone, Stella, Giebel, Sebastian, Mohty, Mohamad, and Nagler, Arnon

Subjects
surgical procedures, operative, immune system diseases, chemical and pharmacologic phenomena
Abstract

Causes of death according to GVHD prophylaxis. (DOCX 17 kb)

Published
2017
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20. Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

Author

Santoro, Nicole, primary, Ruggeri, Annalisa, additional, Labopin, Myriam, additional, Bacigalupo, Andrea, additional, Ciceri, Fabio, additional, Gülbaş, Zafer, additional, Huang, He, additional, Afanasyev, Boris, additional, Arcese, William, additional, Wu, Depei, additional, Koc, Yener, additional, Tischer, Johanna, additional, Santarone, Stella, additional, Giebel, Sebastian, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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23. A Screening Instrument for Chronic Fatigue Syndrome

Author

Jason, Leonard A., primary, Ropacki, Michael T., additional, Santoro, Nicole B., additional, Richman, Judith A., additional, Heatherly, Wendy, additional, Taylor, Renee, additional, Ferrari, Joseph R., additional, Haneydavis, Trina M., additional, Rademaker, Alfred, additional, Dupuis, Josee, additional, Golding, Jacqueline, additional, Plioplys, Audrius V., additional, and Plioplys, Sigita, additional

Published
1997
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24. Impact of conditioning intensity on outcomes of haploidentical stem cell transplantation for patients with acute myeloid leukemia over 45 years of age

Author

Annalisa Ruggeri, Nicole Santoro, Johanna Tischer, Daniela Nasso, Gerhard Ehninger, Fabio Ciceri, William Arcese, Mohamad Mohty, Yener Koc, Xiao-Jun Huang, Maria Teresa Van Lint, Bipin N. Savani, Didier Blaise, Benedetto Bruno, Myriam Labopin, Stella Santarone, Arnon Nagler, Santoro, Nicole, Labopin, Myriam, Ciceri, Fabio, Van Lint, Maria Teresa, Nasso, Daniela, Blaise, Didier, Arcese, William, Tischer, Johanna, Bruno, Benedetto, Ehninger, Gerhard, Koc, Yener, Santarone, Stella, Huang, Xiao-Jun, Savani, Bipin N., Mohty, Mohamad, Ruggeri, Annalisa, and Nagler, Arnon

Subjects
Male, Oncology, Cancer Research, Transplantation Conditioning, Graft vs Host Disease, Disease, law.invention, 0302 clinical medicine, Randomized controlled trial, law, hemic and lymphatic diseases, Medicine, Registries, 030212 general & internal medicine, Aged, 80 and over, Incidence (epidemiology), Age Factors, Hematopoietic Stem Cell Transplantation, Myeloid leukemia, Middle Aged, Prognosis, acute myeloid leukemia, haploidentical stem cell transplantation, myeloablative conditioning, reduced intensity conditioning, Europe, Leukemia, Myeloid, Acute, Treatment Outcome, surgical procedures, operative, 030220 oncology & carcinogenesis, Female, Stem cell, medicine.drug, medicine.medical_specialty, Cyclophosphamide, 03 medical and health sciences, Internal medicine, Humans, Aged, Retrospective Studies, Performance status, business.industry, Siblings, Myeloablative Agonists, Transplantation, Transplantation, Haploidentical, business, Settore MED/15 - Malattie del Sangue
Abstract

Background: T cell–replete haploidentical stem cell transplantation (haplo-SCT) is a valid therapeutic option for adult patients with high-risk acute myeloid leukemia (AML) lacking an HLA-matched sibling or unrelated donor. Method: We retrospectively analyzed the outcomes of 912 AML patients ≥45 years of age who had undergone haplo-SCT with either myeloablative conditioning (MAC; n=373) or reduced intensity conditioning (RIC; n=539) regimens. Results: The median follow-up was 31.1 and 25.7 months for MAC and RIC, respectively. The incidence of relapse and nonrelapse mortality (NRM) were 25.1% versus 28.7% and 31.0% versus 30.3% for MAC and RIC, respectively; 2-year leukemia-free survival (LFS) was 43.9% for MAC versus 41.0% for RIC. In multivariate analysis, the use of MAC versus RIC was not associated with a difference in the outcomes. Results were confirmed in the propensity score–weighted analysis. Disease status and performance status at transplantation were associated with outcomes. Notably, the use of posttransplantation cyclophosphamide was associated with reduced acute graft-versus-host disease (aGVHD) stage III-IV, and NRM and increased overall survival, LFS, and GVHD-free, relapse-free survival. The use of mobilized peripheral blood stem cells was associated with an increased risk of stage II-IV aGVHD. Conclusion: No differences were found between MAC and RIC regimens for haplo-SCT in adults with AML who were ≥45 years of age. The type of GVHD prophylaxis, disease status, and performance status were the major predictors of transplantation outcome. These results may serve as the background for randomized study comparing RIC versus MAC for haplo-SCT in adults with AML.

Published
2019
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25. Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

Author

Johanna Tischer, Arnon Nagler, Yener Koc, Sebastian Giebel, Annalisa Ruggeri, William Arcese, Boris V. Afanasyev, Myriam Labopin, He Huang, Nicole Santoro, Mohamad Mohty, Andrea Bacigalupo, Depei Wu, Stella Santarone, Zafer Gulbas, Fabio Ciceri, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Medicine, Division of Hematology and Clinical Immunology [Perugia, Italy], Università degli Studi di Perugia (UNIPG), Department of Hematology II [Genova, Italy], Ospedale San Martino [Genova, Italy], Università cattolica del Sacro Cuore [Roma] (Unicatt), Hematology and Bone Marrow Transplantation Unit [Milan, Italy], IRCCS Ospedale San Raffaele [Milan, Italy], Hematology Department [Kocaeli, Turkey], Anadolu Medical Center [Kocaeli, Turkey], Bone Marrow Transplantation Center [Zhejiang, China], The First Affiliated Hospital of Zhengzhou University-Zhejiang University School of Medicine [China], Hematology and Transplantology [St. Petersburg, Russian Federation], First Pavlov State Medical University of St. Petersburg [Russian Federation]-Ratsa Gorbacheva Memorial Children's Institute [St. Petersburg, Russian Federation], Department of Hematology [Rome, Italy], Stem Cell Transplant Unit [Rome, Italy], Università degli Studi di Roma Tor Vergata [Roma]-Università degli Studi di Roma Tor Vergata [Roma], Department of Hematology [Jiangsu, China], The First Affiliated Hospital of Soochow University [Suzhou, China], Stem Cell Transplant Unit [Antalya, Turkey], Medical Park Antalya Hospital [Turkey], Department of Internal Medicine III [Munich, Germany], Hematopoietic Stem Cell Transplantation [Munich, Germany], Ludwig Maximilian University [Munich] (LMU)-Ludwig Maximilian University [Munich] (LMU), Department of Hematology and Trasfusional Medicine [Pescara, Italy], Ospedale Civile - BMT Center [Pescara, Italy], Department of Bone Marrow Transplantation and Onco-Hematology [Gliwice, Poland], Center of Oncology - Maria Sklodowska-Curie Memorial Institute, Branch in Gliwice [Poland], Department of Hematology and Bone Marrow Transplantation [Ramat Gan, Israel], Chaim Sheba Medical Center [Ramat Gan, Israel], Santoro, Nicole, Ruggeri, Annalisa, Labopin, Myriam, Bacigalupo, Andrea, Ciceri, Fabio, Gã¼lbaå , Zafer, Huang, He, Afanasyev, Bori, Arcese, William, Wu, Depei, Koc, Yener, Tischer, Johanna, Santarone, Stella, Giebel, Sebastian, Mohty, Mohamad, Nagler, Arnon, BMC, BMC, Università degli Studi di Perugia = University of Perugia (UNIPG), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), and Ratsa Gorbacheva Memorial Children's Institute [St. Petersburg, Russian Federation]-First Pavlov State Medical University of St. Petersburg [Russian Federation]

Subjects
Oncology, Male, Cancer Research, Transplantation Conditioning, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Graft vs Host Disease, Hematopoietic stem cell transplantation, Acute lymphoblastic leukemia, 0302 clinical medicine, hemic and lymphatic diseases, Cumulative incidence, Non-TCD haploidentical, Acute leukemia, Hematology, Hematopoietic Stem Cell Transplantation, lcsh:Diseases of the blood and blood-forming organs, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, surgical procedures, operative, 030220 oncology & carcinogenesis, Female, medicine.drug, Adult, medicine.medical_specialty, Allogenic stem cell transplantation, Cyclophosphamide, Adolescent, lcsh:RC254-282, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, Transplantation, Homologous, Adults, Molecular Biology, Aged, Retrospective Studies, business.industry, lcsh:RC633-647.5, Research, Survival Analysis, Transplantation, Regimen, Bone marrow, Neoplasm Recurrence, Local, business, 030215 immunology
Abstract

Background Allogenic hematopoietic stem cell transplantation (allo-SCT) is the most effective post-remission treatment for adults with high-risk acute lymphoblastic leukemia (ALL). The aim of the study was to analyze results of unmanipulated haploidentical allo-SCT (haplo-SCT) for adults with ALL and to identify prognostic factors. Methods We performed a retrospective analysis on 208 adults transplanted in EBMT centers from 2007 to 2014. Results Median age at haplo-SCT was 32 years and median follow-up, 31 months. Forty-four percent of the patients were in first complete remission (CR1). Stem cell source was the bone marrow (BM) for 43% and peripheral blood (PB) for 57% of patients. Myeloablative conditioning (MAC) was used for 66% and reduced intensity regimen (RIC) for 34% of patients. GVHD prophylaxis was based on post-transplant cyclophosphamide (PT-Cy) for 118 (57%) or on anti-thymocyte-globulin (ATG) for 90 (43%) plus standard prophylaxis. One hundred eighty-four (92%) patients achieved engraftment. Cumulative incidence (CI) of grade II–IV acute-graft-versus-host-disease (GVHD) was 31%, grade III–IV 11%, and chronic GVHD 29%. Non-relapse mortality (NRM) and relapse-incidence (RI) were 32 and 37%, respectively. Overall survival (OS), leukemia-free survival (LFS), and GVHD-free, relapse-free-survival (GRFS) at 3 years were 33, 31, and 26%. For patients in CR1, OS, LFS, and GRFS were 52, 47, and 40%, respectively. Disease status was the main factor associated with transplant outcomes. Use of BM was independently associated with improvement in NRM, acute GVHD, GRFS, LFS, and OS. Conclusions Unmanipulated haplo-SCT may be considered a valid option for adult patients with high-risk ALL lacking HLA identical donor preferably in early disease status. Electronic supplementary material The online version of this article (doi:10.1186/s13045-017-0480-5) contains supplementary material, which is available to authorized users.

Published
2016
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