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1. Neuroendocrine neoplasms of the breast: a review of literature

Author

Vegni, Federica, De Stefano, Ilenia Sara, Policardo, Federica, Tralongo, Pietro, Feraco, Angela, Carlino, Angela, Ferraro, Giulia, Zhang, Qianqian, Scaglione, Giulia, D’Alessandris, Nicoletta, Navarra, Elena, Zannoni, Gianfranco, Santoro, Angela, Mule, Antonino, and Rossi, Esther Diana

Published
2024
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2. Morphological and immunohistochemical evaluation in distinguishing post-radiotherapy serous-like endometrial change (PoRSEC) and serous endometrial intraepithelial carcinoma (SEIC)

Author

Arciuolo, Damiano, Scaglione, Giulia, Travaglino, Antonio, D’Alessandris, Nicoletta, Santoro, Angela, Inzani, Frediano, Urtueta, Belen Padial, Sfregola, Stefania, Raffone, Antonio, Fulgione, Caterina, Valente, Michele, Benvenuto, Roberta, Cianfrini, Federica, and Zannoni, Gian Franco

Published
2024
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4. TRF2 as novel marker of tumor response to taxane-based therapy: from mechanistic insight to clinical implication

Author

Iachettini, Sara, Terrenato, Irene, Porru, Manuela, Di Vito, Serena, Rizzo, Angela, D’Angelo, Carmen, Petti, Eleonora, Dinami, Roberto, Maresca, Carmen, Di Benedetto, Anna, Palange, Aldo, Mulè, Antonino, Santoro, Angela, Palazzo, Antonella, Fuso, Paola, Stoppacciaro, Antonella, Vici, Patrizia, Filomeno, Lorena, Di Lisa, Francesca Sofia, Arcuri, Teresa, Krasniqi, Eriseld, Fabi, Alessandra, Biroccio, Annamaria, and Zizza, Pasquale

Published
2024
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7. Micropapillary pattern in serous borderline ovarian tumor and the risk of extraovarian localization of low-grade serous carcinoma (‘invasive implants’): A systematic review and meta-analysis

Author

Scaglione, Giulia, Travaglino, Antonio, Raffone, Antonio, Santoro, Angela, Arciuolo, Damiano, Fulgione, Caterina, D’Alessandris, Nicoletta, Pannone, Giuseppe, Urtueta, Belen Padial, Narducci, Nadine, Addante, Francesca, Casarin, Jvan, Ronchi, Susanna, Di Lauro, Eleonora, La Rosa, Stefano, Maccio, Livia, Inzani, Frediano, and Zannoni, Gian Franco

Published
2024
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9. The emerging and challenging role of PD-L1 in patients with gynecological cancers: An updating review with clinico-pathological considerations

Author

Santoro, Angela, Angelico, Giuseppe, Inzani, Frediano, Arciuolo, Damiano, d'Amati, Antonio, Addante, Francesca, Travaglino, Antonio, Scaglione, Giulia, D'Alessandris, Nicoletta, Valente, Michele, Tinnirello, Giordana, Raffone, Antonio, Narducci, Nadine, Piermattei, Alessia, Cianfrini, Federica, Bragantini, Emma, and Zannoni, Gian Franco

Published
2024
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10. Sensor and Actuator Electronic System for Active Hand Pose Sensing

Author

Leoni, Alfiero, Colaiuda, Davide, Pantoli, Leonardo, Errico, Vito, Santoro, Angela Scioscia, Saggio, Giovanni, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Di Francia, Girolamo, editor, and Di Natale, Corrado, editor

Published
2023
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13. Endometrial carcinomas with dyshesive, eosinophilic, and vacuolated (histiocyte-like) tumor cells: a reactive-like phenotype associated with aggressive behavior

Author

Travaglino, Antonio, Arciuolo, Damiano, Raffone, Antonio, Santoro, Angela, Piermattei, Alessia, Navarra, Elena, Minucci, Angelo, Mascolo, Massimo, Scaglione, Giulia, D’alessandris, Nicoletta, Valente, Michele, Inzani, Frediano, Mollo, Antonio, Insabato, Luigi, and Zannoni, Gian Franco

Published
2023
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14. Advancing the PD-L1 CPS test in metastatic TNBC: Insights from pathologists and findings from a nationwide survey

Author

Fusco, Nicola, Ivanova, Mariia, Frascarelli, Chiara, Criscitiello, Carmen, Cerbelli, Bruna, Pignataro, Maria Gemma, Pernazza, Angelina, Sajjadi, Elham, Venetis, Konstantinos, Cursano, Giulia, Pagni, Fabio, Di Bella, Camillo, Accardo, Marina, Amato, Michelina, Amico, Paolo, Bartoli, Caterina, Bogina, Giuseppe, Bortesi, Laura, Boldorini, Renzo, Bruno, Sara, Cabibi, Daniela, Caruana, Pietro, Dainese, Emanuele, De Camilli, Elisa, Dell’Anna, Vladimiro, Duda, Loren, Emmanuele, Carmela, Fanelli, Giuseppe Nicolò, Fernandes, Bethania, Ferrara, Gerardo, Gnetti, Letizia, Gurrera, Alessandra, Leone, Giorgia, Lucci, Raffaella, Mancini, Cristina, Marangi, Grazia, Mastropasqua, Mauro G., Nibid, Lorenzo, Orrù, Sandra, Pastena, Maria, Peresi, Monica, Perracchio, Letizia, Santoro, Angela, Vezzosi, Vania, Zambelli, Claudia, Zuccalà, Valeria, Rizzo, Antonio, Costarelli, Leopoldo, Pietribiasi, Francesca, Santinelli, Alfredo, Scatena, Cristian, Curigliano, Giuseppe, Guerini-Rocco, Elena, Martini, Maurizio, Graziano, Paolo, Castellano, Isabella, and d'Amati, Giulia

Published
2023
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25. Identification of a minimum number of genes to predict triple-negative breast cancer subgroups from gene expression profiles

Author

Akhouayri, Laila, Ostano, Paola, Mello-Grand, Maurizia, Gregnanin, Ilaria, Crivelli, Francesca, Laurora, Sara, Liscia, Daniele, Leone, Francesco, Santoro, Angela, Mulè, Antonino, Guarino, Donatella, Maggiore, Claudia, Carlino, Angela, Magno, Stefano, Scatolini, Maria, Di Leone, Alba, Masetti, Riccardo, and Chiorino, Giovanna

Published
2022
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28. Beyond the WHO 2020 Classification of Female Genital Tumors: Types of Endometrial Cancer: A Pathological and Molecular Focus on Challenging Rare Variants.

Author

Santoro, Angela, Angelico, Giuseppe, Travaglino, Antonio, Inzani, Frediano, Arciuolo, Damiano, d'Amati, Antonio, D'Alessandris, Nicoletta, Scaglione, Giulia, Valente, Michele, Urtueta, Belen Padial, Addante, Francesca, Narducci, Nadine, Pannone, Giuseppe, Bragantini, Emma, Raffone, Antonio, Mulè, Antonino, and Zannoni, Gian Franco

Subjects
*ENDOMETRIAL cancer, *CONSCIOUSNESS raising, *MOLECULAR pathology, *MEDICAL research, *ENDOMETRIAL tumors
Abstract

Endometrial carcinoma is a heterogeneous group of malignancies characterized by distinct histopathological features and genetic underpinnings. The 2020 WHO classification has provided a comprehensive framework for the categorization of endometrial carcinoma. However, it has not fully addressed the spectrum of uncommon entities that are currently not recognized by the 2020 WHO and have only been described in the form of small case series and case reports. These neoplasms represent a real diagnostic challenge for pathologists; furthermore, their therapeutic management still remains controversial and information regarding tumor prognosis is very limited. This review aims to elucidate these lesser-known variants of endometrial carcinoma. We discuss the challenges of identifying these rare subtypes and the molecular alterations associated with them. Furthermore, we propose the need for expanded classification systems that include these variants to enhance clinical outcomes and research efforts. We believe that a better histological typing characterization of these entities may lead to more reproducible and accurate diagnoses and more personalized treatments. By raising awareness of these rare entities, we also hope to encourage further investigation and integration into clinical practice to improve patient care in endometrial carcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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29. TLR4 Downregulation Identifies High-Risk HPV Infection and Integration in H-SIL and Squamous Cell Carcinomas of the Uterine Cervix.

Author

Santoro, Angela, Angelico, Giuseppe, Arciuolo, Damiano, Scaglione, Giulia, Padial Urtueta, Belen, Aquino, Gabriella, Starita, Noemy, Tornesello, Maria Lina, Rega, Rosalia Anna, Pedicillo, Maria Carmela, Mazzucchelli, Manuel, Stefano, Ilenia Sara De, Zamparese, Rosanna, Campisi, Giuseppina, Mori, Giorgio, Zannoni, Gian Franco, and Pannone, Giuseppe

Published
2024
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37. Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications

Author

Addante, F, D'Amati, A, Santoro, Angela, Angelico, G, Inzani, Frediano, Arciuolo, Damiano, Travaglino, A, Raffone, A, D'Alessandris, Nicoletta, Scaglione, G, Valente, Michele, Tinnirello, G, Sfregola, S, Padial Urtueta, B, Piermattei, Angelo, Cianfrini, F, Mulè, A, Bragantini, E, Zannoni, Gian Franco, Santoro A (ORCID:0000-0002-6964-5152), Inzani F, Arciuolo D, D'Alessandris N, Valente M, Piermattei A (ORCID:0000-0002-6835-1179), Zannoni GF (ORCID:0000-0003-1809-129X), Addante, F, D'Amati, A, Santoro, Angela, Angelico, G, Inzani, Frediano, Arciuolo, Damiano, Travaglino, A, Raffone, A, D'Alessandris, Nicoletta, Scaglione, G, Valente, Michele, Tinnirello, G, Sfregola, S, Padial Urtueta, B, Piermattei, Angelo, Cianfrini, F, Mulè, A, Bragantini, E, Zannoni, Gian Franco, Santoro A (ORCID:0000-0002-6964-5152), Inzani F, Arciuolo D, D'Alessandris N, Valente M, Piermattei A (ORCID:0000-0002-6835-1179), and Zannoni GF (ORCID:0000-0003-1809-129X)

Abstract

Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status.

Published
2024

40. Atypical glandular cells and predictive features of malignancy in Pap smears: A retrospective monocentric study.

Author

Cianfrini, Federica, d'Amati, Antonio, Arciuolo, Damiano, Travaglino, Antonio, D'Alessandris, Nicoletta, Scaglione, Giulia, Valente, Michele, Urtueta, Belen Padial, Addante, Francesca, Narducci, Nadine, Angelico, Giuseppe, Piermattei, Alessia, Mulè, Antonino, Santoro, Angela, Rossi, Esther Diana, and Zannoni, Gian Franco

Subjects
PAP test, MEDICAL screening, CERVICAL cancer, SURGICAL excision, CANCER-related mortality, CYTODIAGNOSIS, LYMPHOCYTE count
Abstract

Objective: The introduction of cytological screening with the Papanicolau smear significantly reduced cervical cancer mortality. However, Pap smear examination can be challenging, being based on the observer ability to decode different cytological and architectural features. This study aims to evaluate the malignancy rate of AGC (atypical glandular cells) category, investigating the relationships between cytological and histological diagnosis. Methods: Eighty‐nine patients, diagnosed as AGC at cytological evaluation and followed up with biopsy or surgical procedure at Policlinico Gemelli Hospital, Rome, Italy, were included in the study. The cytopathological architectural (feathering, rosette formation, overlapping, loss of polarity, papillary formation, three‐dimensional formation) and nuclear (N/C ratio, nuclear enlargement and hyperchromasia, mitoses, nuclei irregularity, evident nucleoli) features of AGC were evaluated. Statistical analyses were performed to assess cyto‐histological correlation and determine the relevance of architectural and nuclear features in the diagnosis of malignancy. Results: Of the 89 AGC patients, 48 cases (53.93%) were diagnosed as AGC‐NOS and 41 (46.07%) were diagnosed as AGC‐FN, according to the Bethesda classification system. The follow‐up biopsies or surgical resections revealed malignancy in 46 patients (51.69%). The rates of malignancy for AGC‐NOS and AGC‐FN were 35.41% and 70.73% respectively. Furthermore, analysing cytopathological features, we found that both architectural and nuclear criteria were statistically significant (p < 0.05). Only overlapping, nuclear irregularity and increased N/C ratio were not found to be statistically significant for detecting malignancy. Conclusions: Cytological diagnosis of glandular lesions remains a valid tool, when appropriate clinical correlation and expert evaluation are available. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Oncotype DX Predictive Nomogram for Recurrence Score Output: The Novel System ADAPTED01 Based on Quantitative Immunochemistry Analysis

Author

Marazzi, Fabio, Barone, Roberto, Masiello, Valeria, Magri, Valentina, Mulè, Antonino, Santoro, Angela, Cacciatori, Federica, Boldrini, Luca, Franceschini, Gianluca, Moschella, Francesca, Naso, Giuseppe, Tomao, Silverio, Gambacorta, Maria Antonietta, Mantini, Giovanna, Masetti, Riccardo, Smaniotto, Daniela, and Valentini, Vincenzo

Published
2020
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49. Recent Advances in Cervical Cancer Management: A Review on Novel Prognostic Factors in Primary and Recurrent Tumors

Author

Santoro, Angela, Inzani, Frediano, Angelico, Giuseppe, Arciuolo, Damiano, Bragantini, Emma, Travaglino, Antonio, Valente, Michele, D'Alessandris, Nicoletta, Scaglione, Giulia, Sfregola, Stefania, Piermattei, Alessia, Cianfrini, Federica, Roberti, Paola, Zannoni, Gian Franco, Santoro, Angela (ORCID:0000-0002-6964-5152), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Santoro, Angela, Inzani, Frediano, Angelico, Giuseppe, Arciuolo, Damiano, Bragantini, Emma, Travaglino, Antonio, Valente, Michele, D'Alessandris, Nicoletta, Scaglione, Giulia, Sfregola, Stefania, Piermattei, Alessia, Cianfrini, Federica, Roberti, Paola, Zannoni, Gian Franco, Santoro, Angela (ORCID:0000-0002-6964-5152), and Zannoni, Gian Franco (ORCID:0000-0003-1809-129X)

Abstract

Simple Summary The aim of the present review is to analyze the novel and most relevant prognostic factors in primary and recurrent cervical cancer. Based on our findings, tumour budding and cell nest size grading system, depth of stromal invasion, lympho-vascular space invasion, perineural invasion, tumor free distance and tumor infiltrating lymphocytes appeared the most relevant factors which may be included in the pathology report to help future studies to further elucidate cervical cancer prognosis. Background: Several pathological parameters, including tumor size, depth of stromal invasion, lympho-vascular space invasion and lymph node status, have been proposed as prognostic predictors in cervical cancer. However, given the high mortality and recurrence rate of cervical cancer, novel parameters that are able to provide additional prognostic information are needed in order to allow a better prognostic stratification of cervical cancer patients. Methods: A search was conducted on PubMed to identify relevant literature data regarding prognostic factors in cervical cancer. The key words "cervical cancer", "prognostic factors", "pathology", and "outcome" were used. Results: The novel pathological grading system based on tumor budding and cell nest size appeared the most relevant prognostic factor in primary neoplasms. Moreover, other potentially useful prognostic factors were tumor size, depth of stromal invasion, lympho-vascular space invasion, perineural invasion, tumor-free distance and tumor-infiltrating lymphocytes. Prognostic factors related to advanced-stage cervical cancer, including lymph-nodes status, endometrial and cervical involvement as well as distant metastases, were also taken into consideration. Conclusions: According to our findings, tumor budding and cell nest size grading system, depth of stromal invasion, lympho-vascular space invasion, perineural invasion, tumor-free distance and tumor-infiltrating lymphocytes appeared the most relevant factor

Published
2023

50. The Role of Plasma Cells as a Marker of Chronic Endometritis: A Systematic Review and Meta-Analysis

Author

Santoro, Angela, Travaglino, Antonio, Inzani, Frediano, Angelico, Giuseppe, Raffone, Antonio, Maruotti, Giuseppe Maria, Straccia, Patrizia, Arciuolo, Damiano, Castri, Federica, D'Alessandris, Nicoletta, Scaglione, Giulia, Valente, Michele, Cianfrini, Federica, Masciullo, Valeria, Zannoni, Gian Franco, Santoro, Angela (ORCID:0000-0002-6964-5152), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Santoro, Angela, Travaglino, Antonio, Inzani, Frediano, Angelico, Giuseppe, Raffone, Antonio, Maruotti, Giuseppe Maria, Straccia, Patrizia, Arciuolo, Damiano, Castri, Federica, D'Alessandris, Nicoletta, Scaglione, Giulia, Valente, Michele, Cianfrini, Federica, Masciullo, Valeria, Zannoni, Gian Franco, Santoro, Angela (ORCID:0000-0002-6964-5152), and Zannoni, Gian Franco (ORCID:0000-0003-1809-129X)

Abstract

Chronic endometritis (CE) is the persistent inflammation of the endometrial lining associated with infertility and various forms of reproductive failures. The diagnosis of CE is based on the histological evidence of stromal plasma cells; however, standardized methods to assess plasma cells are still lacking. In the present paper, we aimed to determine the most appropriate plasma cell threshold to diagnose CE based on pregnancy outcomes. Three electronic databases were searched from their inception to February 2022 for all studies comparing pregnancy outcomes between patients with CE and patients without CE. The relative risk (RR) of pregnancy, miscarriage, and/or live birth rates were calculated and pooled based on the plasma cell threshold adopted. A p-value < 0.05 was considered significant. Nine studies adopting different thresholds (1 to 50 plasma cells/10 HPF) were included. In the meta-analysis, we only found a significant association between miscarriage rate and a plasma cell count & GE; 5/10 HPF (RR = 2.4; p = 0.007). Among studies not suitable for meta-analysis, CE showed an association with worsened pregnancy only when high thresholds (10 and 50/10 HPF) were adopted. In conclusion, our study suggests that the presence of plasma cells at low levels (<5/10 HPF) may not predict worsened pregnancy outcomes. Based on these findings, a threshold of & GE;5 plasma cells/10 HPF may be more appropriate to diagnose CE.

Published
2023

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