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1. Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition

Author

Botteri, E, Peveri, G, Berstad, P, Bagnardi, V, Hoff, G, Heath, A, Cross, A, Vineis, P, Dossus, L, Johansson, M, Freisling, H, Matta, K, Huybrechts, I, Chen, S, B. Borch, K, Sandanger, T, H. Nost, T, Dahm, C, Antoniussen, C, Tin Tin, S, Fournier, A, Marques, C, Artaud, F, Sanchez, M, Guevara, M, Santiuste, C, Agudo, A, Bajracharya, R, Katzke, V, Ricceri, F, Agnoli, C, Bergmann, M, Schulze, M, Panico, S, Masala, G, Tjonneland, A, Olsen, A, Stocks, T, Manjer, J, Aizpurua-Atxega, A, Weiderpass, E, Riboli, E, Gunter, M, Ferrari, P, Botteri E., Peveri G., Berstad P., Bagnardi V., Hoff G., Heath A. K., Cross A. J., Vineis P., Dossus L., Johansson M., Freisling H., Matta K., Huybrechts I., Chen S. L. F., B. Borch K., Sandanger T. M., H. Nost T., Dahm C. C., Antoniussen C. S., Tin Tin S., Fournier A., Marques C., Artaud F., Sanchez M. -J., Guevara M., Santiuste C., Agudo A., Bajracharya R., Katzke V., Ricceri F., Agnoli C., Bergmann M. M., Schulze M. B., Panico S., Masala G., Tjonneland A., Olsen A., Stocks T., Manjer J., Aizpurua-Atxega A., Weiderpass E., Riboli E., Gunter M. J., Ferrari P., Botteri, E, Peveri, G, Berstad, P, Bagnardi, V, Hoff, G, Heath, A, Cross, A, Vineis, P, Dossus, L, Johansson, M, Freisling, H, Matta, K, Huybrechts, I, Chen, S, B. Borch, K, Sandanger, T, H. Nost, T, Dahm, C, Antoniussen, C, Tin Tin, S, Fournier, A, Marques, C, Artaud, F, Sanchez, M, Guevara, M, Santiuste, C, Agudo, A, Bajracharya, R, Katzke, V, Ricceri, F, Agnoli, C, Bergmann, M, Schulze, M, Panico, S, Masala, G, Tjonneland, A, Olsen, A, Stocks, T, Manjer, J, Aizpurua-Atxega, A, Weiderpass, E, Riboli, E, Gunter, M, Ferrari, P, Botteri E., Peveri G., Berstad P., Bagnardi V., Hoff G., Heath A. K., Cross A. J., Vineis P., Dossus L., Johansson M., Freisling H., Matta K., Huybrechts I., Chen S. L. F., B. Borch K., Sandanger T. M., H. Nost T., Dahm C. C., Antoniussen C. S., Tin Tin S., Fournier A., Marques C., Artaud F., Sanchez M. -J., Guevara M., Santiuste C., Agudo A., Bajracharya R., Katzke V., Ricceri F., Agnoli C., Bergmann M. M., Schulze M. B., Panico S., Masala G., Tjonneland A., Olsen A., Stocks T., Manjer J., Aizpurua-Atxega A., Weiderpass E., Riboli E., Gunter M. J., and Ferrari P.

Abstract

In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers—including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others—using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95–0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07–1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65–0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk.

Published
2024

17. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: A multinational cohort study

Author

Freisling, H, Viallon, V, Lennon, H, Bagnardi, V, Ricci, C, Butterworth, A, Sweeting, M, Muller, D, Romieu, I, Bazelle, P, Kvaskoff, M, Arveux, P, Severi, G, Bamia, C, Kuhn, T, Kaaks, R, Bergmann, M, Boeing, H, Tjonneland, A, Olsen, A, Overvad, K, Dahm, C, Menendez, V, Agudo, A, Sanchez, M, Amiano, P, Santiuste, C, Gurrea, A, Tong, T, Schmidt, J, Tzoulaki, I, Tsilidis, K, Ward, H, Palli, D, Agnoli, C, Tumino, R, Ricceri, F, Panico, S, Picavet, H, Bakker, M, Monninkhof, E, Nilsson, P, Manjer, J, Rolandsson, O, Thysell, E, Weiderpass, E, Jenab, M, Riboli, E, Vineis, P, Danesh, J, Wareham, N, Gunter, M, Ferrari, P, Freisling H., Viallon V., Lennon H., Bagnardi V., Ricci C., Butterworth A. S., Sweeting M., Muller D., Romieu I., Bazelle P., Kvaskoff M., Arveux P., Severi G., Bamia C., Kuhn T., Kaaks R., Bergmann M., Boeing H., Tjonneland A., Olsen A., Overvad K., Dahm C. C., Menendez V., Agudo A., Sanchez M. -J., Amiano P., Santiuste C., Gurrea A. B., Tong T. Y. N., Schmidt J. A., Tzoulaki I., Tsilidis K. K., Ward H., Palli D., Agnoli C., Tumino R., Ricceri F., Panico S., Picavet H. S. J., Bakker M., Monninkhof E., Nilsson P., Manjer J., Rolandsson O., Thysell E., Weiderpass E., Jenab M., Riboli E., Vineis P., Danesh J., Wareham N. J., Gunter M. J., Ferrari P., Freisling, H, Viallon, V, Lennon, H, Bagnardi, V, Ricci, C, Butterworth, A, Sweeting, M, Muller, D, Romieu, I, Bazelle, P, Kvaskoff, M, Arveux, P, Severi, G, Bamia, C, Kuhn, T, Kaaks, R, Bergmann, M, Boeing, H, Tjonneland, A, Olsen, A, Overvad, K, Dahm, C, Menendez, V, Agudo, A, Sanchez, M, Amiano, P, Santiuste, C, Gurrea, A, Tong, T, Schmidt, J, Tzoulaki, I, Tsilidis, K, Ward, H, Palli, D, Agnoli, C, Tumino, R, Ricceri, F, Panico, S, Picavet, H, Bakker, M, Monninkhof, E, Nilsson, P, Manjer, J, Rolandsson, O, Thysell, E, Weiderpass, E, Jenab, M, Riboli, E, Vineis, P, Danesh, J, Wareham, N, Gunter, M, Ferrari, P, Freisling H., Viallon V., Lennon H., Bagnardi V., Ricci C., Butterworth A. S., Sweeting M., Muller D., Romieu I., Bazelle P., Kvaskoff M., Arveux P., Severi G., Bamia C., Kuhn T., Kaaks R., Bergmann M., Boeing H., Tjonneland A., Olsen A., Overvad K., Dahm C. C., Menendez V., Agudo A., Sanchez M. -J., Amiano P., Santiuste C., Gurrea A. B., Tong T. Y. N., Schmidt J. A., Tzoulaki I., Tsilidis K. K., Ward H., Palli D., Agnoli C., Tumino R., Ricceri F., Panico S., Picavet H. S. J., Bakker M., Monninkhof E., Nilsson P., Manjer J., Rolandsson O., Thysell E., Weiderpass E., Jenab M., Riboli E., Vineis P., Danesh J., Wareham N. J., Gunter M. J., and Ferrari P.

Abstract

Background: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. Methods: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. Results: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and

Published
2020

18. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

Author

Gaziano, L, Sun, L, Arnold, M, Bell, S, Cho, K, Kaptoge, SK, Song, RJ, Burgess, S, Posner, DC, Mosconi, K, Cohen, CR, Mason, AM, Bolton, TR, Tao, R, Allara, E, Schubert, P, Chen, L, Staley, JR, Staplin, N, Altay, S, Amiano, P, Arndt, PV, Arnlov, J, Barr, ELM, Bjorkelund, C, Boer, JMA, Brenner, H, Casiglia, E, Chiodini, P, Cooper, JA, Coresh, J, Cushman, M, Dankner, R, Davidson, KW, de Jongh, RT, Donfrancesco, C, Engstrom, G, Freisling, H, de la Camara, AG, Gudnason, V, Hankey, GJ, Hansson, P, Heath, AK, Hoorn, EJ, Imano, H, Jassal, SK, Kaaks, R, Katzke, V, Kauhanen, J, Kiechl, S, Koenig, W, Kronmal, RA, Kyro, C, Lawlor, DA, Ljungberg, B, MacDonald, C, Masala, G, Meisinger, C, Melander, O, Iribas, CM, Ninomiya, T, Nitsch, D, Nordestgaard, BG, OnlandMoret, C, Palmieri, L, Petrova, D, Garcia, JRQ, Rosengren, A, Sacerdote, C, Sakurai, M, Santiuste, C, Schulze, MB, Sieri, S, Sundstrom, J, Tikhonoff, V, Tjonneland, A, Tong, T, Tumino, R, Tzoulaki, I, van der Schouw, YT, Verschuren, WMM, Volzke, H, Wallace, RB, Wannamethee, SG, Weiderpass, E, Willeit, P, Woodward, M, Yamagishi, K, ZamoraRos, R, Akwo, EA, Pyarajan, S, Gagnon, DR, Tsao, PS, Muralidhar, S, Edwards, TL, Damrauer, SM, Joseph, J, Pennells, L, Wilson, PWF, Harrison, S, Gaziano, TA, Inouye, M, Baigent, C, Casas, JP, Langenberg, C, Wareham, N, Riboli, E, Gaziano, JM, Danesh, J, Hung, AM, Butterworth, AS, Wood, AM, Di Angelantonio, E, Gaziano, L, Sun, L, Arnold, M, Bell, S, Cho, K, Kaptoge, SK, Song, RJ, Burgess, S, Posner, DC, Mosconi, K, Cohen, CR, Mason, AM, Bolton, TR, Tao, R, Allara, E, Schubert, P, Chen, L, Staley, JR, Staplin, N, Altay, S, Amiano, P, Arndt, PV, Arnlov, J, Barr, ELM, Bjorkelund, C, Boer, JMA, Brenner, H, Casiglia, E, Chiodini, P, Cooper, JA, Coresh, J, Cushman, M, Dankner, R, Davidson, KW, de Jongh, RT, Donfrancesco, C, Engstrom, G, Freisling, H, de la Camara, AG, Gudnason, V, Hankey, GJ, Hansson, P, Heath, AK, Hoorn, EJ, Imano, H, Jassal, SK, Kaaks, R, Katzke, V, Kauhanen, J, Kiechl, S, Koenig, W, Kronmal, RA, Kyro, C, Lawlor, DA, Ljungberg, B, MacDonald, C, Masala, G, Meisinger, C, Melander, O, Iribas, CM, Ninomiya, T, Nitsch, D, Nordestgaard, BG, OnlandMoret, C, Palmieri, L, Petrova, D, Garcia, JRQ, Rosengren, A, Sacerdote, C, Sakurai, M, Santiuste, C, Schulze, MB, Sieri, S, Sundstrom, J, Tikhonoff, V, Tjonneland, A, Tong, T, Tumino, R, Tzoulaki, I, van der Schouw, YT, Verschuren, WMM, Volzke, H, Wallace, RB, Wannamethee, SG, Weiderpass, E, Willeit, P, Woodward, M, Yamagishi, K, ZamoraRos, R, Akwo, EA, Pyarajan, S, Gagnon, DR, Tsao, PS, Muralidhar, S, Edwards, TL, Damrauer, SM, Joseph, J, Pennells, L, Wilson, PWF, Harrison, S, Gaziano, TA, Inouye, M, Baigent, C, Casas, JP, Langenberg, C, Wareham, N, Riboli, E, Gaziano, JM, Danesh, J, Hung, AM, Butterworth, AS, Wood, AM, and Di Angelantonio, E

Abstract

BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches th

Published
2022

24. Drilling of biocomposite materials: Modelling and experimental validation

Author

Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials, Comunidad de Madrid, AGENCIA ESTATAL DE INVESTIGACION, Agencia Estatal de Investigación, European Regional Development Fund, Ministerio de Economía y Competitividad, Diaz-Alvarez, A., Diaz-Alvarez, J., Feito-Sánchez, Norberto, Santiuste, C., Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials, Comunidad de Madrid, AGENCIA ESTATAL DE INVESTIGACION, Agencia Estatal de Investigación, European Regional Development Fund, Ministerio de Economía y Competitividad, Diaz-Alvarez, A., Diaz-Alvarez, J., Feito-Sánchez, Norberto, and Santiuste, C.

Abstract

[EN] Induced damage during biocomposites drilling is significantly different to that produced on composites based on synthetic reinforcement such as carbon or glass fibers. In composites reinforced with carbon or glass fibers, induced damage increases with feed rate, however damage was observed to decrease with feed rate in biocomposites reinforced with natural fibers. This work is focused on the explanation of this differences between biocomposites and traditional composites based on the effect of strain rate on the material behavior during machining. A FEM model has been developed in ABAQUS/Explicit to verify this hypothesis. This numerical model has been used to explain the differences found between traditional composites and biocomposites in the influence of the main drilling parameters on induced damage during drilling. Experimental tests were conducted to validate the model through the comparison between thrust forces and damage factor for two different drills geometries on Flax/PLA bio composites. The results indicate that the decrease of induced damage with feed rate is only predicted when the constitutive model accounts for experimental behavior observed in this type of composites. Additionally, the numerical model demonstrated the ability to reproduce the effect of the different cutting conditions (cutting speed, feed, thickness and drill geometry) observed during experimental tests on induced damage during drilling.

Published
2021

26. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author

Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
prospective cohort study, pancreatic cancer, nuts, seeds, diet, EPIC, intake
Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Published
2020

27. A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Author

Papadimitriou, N. Muller, D. van den Brandt, P.A. Geybels, M. Patel, C.J. Gunter, M.J. Lopez, D.S. Key, T.J. Perez-Cornago, A. Ferrari, P. Vineis, P. Weiderpass, E. Boeing, H. Agudo, A. Sánchez, M.-J. Overvad, K. Kühn, T. Fortner, R.T. Palli, D. Drake, I. Bjartell, A. Santiuste, C. Bueno-de-Mesquita, B.H. Krogh, V. Tjønneland, A. Lauritzen, D.F. Gurrea, A.B. Quirós, J.R. Stattin, P. Trichopoulou, A. Martimianaki, G. Karakatsani, A. Thysell, E. Johansson, I. Ricceri, F. Tumino, R. Larrañaga, N. Khaw, K.T. Riboli, E. Tzoulaki, I. Tsilidis, K.K.

Abstract

Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR ' 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature. © 2019, The Author(s).

Published
2020

28. Menstrual factors, reproductive history, hormone use, and urothelial carcinoma risk: a prospective study in the EPIC cohort

Author

Lujan-Barroso, L. Botteri, E. Caini, S. Ljungberg, B.F. Roswall, N. Tjønneland, A. Bueno-De-Mesquita, B. Gram, I.T. Tumino, R. Kiemeney, L.A. Liedberg, F. Stocks, T. Gunter, M.J. Murphy, N. Cervenka, I. Fournier, A. Kvaskoff, M. Haggstrom, C. Overvad, K. Lund, E. Waaseth, M. Fortner, R.T. Kuhn, T. Menendez, V. Sanchez, M.-J. Santiuste, C. Perez-Cornago, A. Zamora-Ros, R. Cross, A.J. Trichopoulou, A. Karakatsani, A. Peppa, E. Palli, D. Krogh, V. Sciannameo, V. Mattiello, A. Panico, S. van Gils, C.H. Charlotte Onland-Moret, N. Barricarte, A. Amiano, P. Khaw, K.-T. Boeing, H. Weiderpass, E. Duell, E.J.

Abstract

Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non–muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models. Results: During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR≥5vs1 ¼ 0.48; 0.25–0.90; Ptrend in parous women ¼ 0.010) and MHT use (compared with nonuse) was positively associated with urothelial carcinoma risk (HR ¼ 1.27; 1.03–1.57), but no dose response by years of MHT use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analyses in never smokers showed similar HR patterns for the number of FTP, while no association between MHT use and urothelial carcinoma risk was observed. Association between MHT use and urothelial carcinoma risk remained significant only in current smokers. No heterogeneity of the risk estimations in the final model was observed by tumor aggressiveness or by tumor grade. A positive association between MTH use and non–muscle-invasive urothelial carcinoma risk was observed. Conclusions: Our results support that increasing the number of FTP may reduce urothelial carcinoma risk. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells. © 2020 American Association for Cancer Research.

Published
2020

29. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: A multinational cohort study

Author

Freisling, H. Viallon, V. Lennon, H. Bagnardi, V. Ricci, C. Butterworth, A.S. Sweeting, M. Muller, D. Romieu, I. Bazelle, P. Kvaskoff, M. Arveux, P. Severi, G. Bamia, C. Kühn, T. Kaaks, R. Bergmann, M. Boeing, H. Tjønneland, A. Olsen, A. Overvad, K. Dahm, C.C. Menéndez, V. Agudo, A. Sánchez, M.-J. Amiano, P. Santiuste, C. Gurrea, A.B. Tong, T.Y.N. Schmidt, J.A. Tzoulaki, I. Tsilidis, K.K. Ward, H. Palli, D. Agnoli, C. Tumino, R. Ricceri, F. Panico, S. Picavet, H.S.J. Bakker, M. Monninkhof, E. Nilsson, P. Manjer, J. Rolandsson, O. Thysell, E. Weiderpass, E. Jenab, M. Riboli, E. Vineis, P. Danesh, J. Wareham, N.J. Gunter, M.J. Ferrari, P.

Abstract

Background: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. Methods: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. Results: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and women with healthy lifestyles. Conclusion: Pre-diagnostic healthy lifestyle behaviours were strongly inversely associated with the risk of cancer and cardiometabolic diseases, and with the prognosis of these diseases by reducing risk of multimorbidity. © 2020 The Author(s).

Published
2020

30. Antibody responses to helicobacter pylori and risk of developing colorectal cancer in a European cohort

Author

Butt, J. Jenab, M. Pawlita, M. Tjønneland, A. Kyrø, C. Boutron-Ruault, M.-C. Carbonnel, F. Dong, C. Kaaks, R. Kuhn, T. Boeing, H. Schulze, M.B. Trichopoulou, A. Karakatsani, A. Vecchia, C.L. Palli, D. Agnoli, C. Tumino, R. Sacerdote, C. Panico, S. Bueno-De-Mesquita, B. Vermeulen, R. Gram, I.T. Weiderpass, E. Borch, K.B. Quiros, J.R. Agudo, A. Rodríguez-Barranco, M. Santiuste, C. Ardanaz, E. van Guelpen, B. Harlid, S. Imaz, L. Perez-Cornago, A. Gunter, M.J. Zouiouich, S. Park, J.Y. Riboli, E. Cross, A.J. Heath, A.K. Waterboer, T. Hughes, D.J.

Subjects
bacterial infections and mycoses
Abstract

Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00–1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19–2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99–1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence. © 2020 American Association for Cancer Research.

Published
2020

31. Antibody responses to helicobacter pylori and risk of developing colorectal cancer in a European cohort

Author

Butt, J., Jenab, M., Pawlita, M., Tjønneland, A., Kyrø, C., Boutron-Ruault, M.-C., Carbonnel, F., Dong, C., Kaaks, R., Kuhn, T., Boeing, H., Schulze, M.B., Trichopoulou, A., Karakatsani, A., Vecchia, C.L., Palli, D., Agnoli, C., Tumino, R., Sacerdote, C., Panico, S., Bueno-De-Mesquita, B., Vermeulen, R., Gram, I.T., Weiderpass, E., Borch, K.B., Quiros, J.R., Agudo, A., Rodríguez-Barranco, M., Santiuste, C., Ardanaz, E., van Guelpen, B., Harlid, S., Imaz, L., Perez-Cornago, A., Gunter, M.J., Zouiouich, S., Riboli, E., Cross, A.J., Heath, A.K., Waterboer, T., Hughes, D.J., Butt, J., Jenab, M., Pawlita, M., Tjønneland, A., Kyrø, C., Boutron-Ruault, M.-C., Carbonnel, F., Dong, C., Kaaks, R., Kuhn, T., Boeing, H., Schulze, M.B., Trichopoulou, A., Karakatsani, A., Vecchia, C.L., Palli, D., Agnoli, C., Tumino, R., Sacerdote, C., Panico, S., Bueno-De-Mesquita, B., Vermeulen, R., Gram, I.T., Weiderpass, E., Borch, K.B., Quiros, J.R., Agudo, A., Rodríguez-Barranco, M., Santiuste, C., Ardanaz, E., van Guelpen, B., Harlid, S., Imaz, L., Perez-Cornago, A., Gunter, M.J., Zouiouich, S., Riboli, E., Cross, A.J., Heath, A.K., Waterboer, T., and Hughes, D.J.

Abstract

Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00–1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19–2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99–1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence.

Published
2020

32. Antibody responses to helicobacter pylori and risk of developing colorectal cancer in a European cohort

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Butt, J., Jenab, M., Pawlita, M., Tjønneland, A., Kyrø, C., Boutron-Ruault, M.-C., Carbonnel, F., Dong, C., Kaaks, R., Kuhn, T., Boeing, H., Schulze, M.B., Trichopoulou, A., Karakatsani, A., Vecchia, C.L., Palli, D., Agnoli, C., Tumino, R., Sacerdote, C., Panico, S., Bueno-De-Mesquita, B., Vermeulen, R., Gram, I.T., Weiderpass, E., Borch, K.B., Quiros, J.R., Agudo, A., Rodríguez-Barranco, M., Santiuste, C., Ardanaz, E., van Guelpen, B., Harlid, S., Imaz, L., Perez-Cornago, A., Gunter, M.J., Zouiouich, S., Riboli, E., Cross, A.J., Heath, A.K., Waterboer, T., Hughes, D.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Butt, J., Jenab, M., Pawlita, M., Tjønneland, A., Kyrø, C., Boutron-Ruault, M.-C., Carbonnel, F., Dong, C., Kaaks, R., Kuhn, T., Boeing, H., Schulze, M.B., Trichopoulou, A., Karakatsani, A., Vecchia, C.L., Palli, D., Agnoli, C., Tumino, R., Sacerdote, C., Panico, S., Bueno-De-Mesquita, B., Vermeulen, R., Gram, I.T., Weiderpass, E., Borch, K.B., Quiros, J.R., Agudo, A., Rodríguez-Barranco, M., Santiuste, C., Ardanaz, E., van Guelpen, B., Harlid, S., Imaz, L., Perez-Cornago, A., Gunter, M.J., Zouiouich, S., Riboli, E., Cross, A.J., Heath, A.K., Waterboer, T., and Hughes, D.J.

Published
2020

33. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., and Duell, E.J.

Published
2020

35. Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women: Results from the EPIC Cohort

Author

Sarink, D. Yang, J. Johnson, T. Chang-Claude, J. Overvad, K. Olsen, A. Tjønneland, A. Fournier, A. Mancini, F.R. Kvaskoff, M. Boeing, H. Trichopoulou, A. Karakatsani, A. Valanou, E. Agnoli, C. Sacerdote, C. Masala, G. Mattiello, A. Tumino, R. Van Gils, C.H. Skeie, G. Gram, I.T. Weiderpass, E. Lujan-Barroso, L. Petrova, D. Santiuste, C. Quirós, J.R. Barricarte, A. Amiano, P. Travis, R.C. Gunter, M. Dossus, L. Christakoudi, S. Kaaks, R. Fortner, R.T.

Subjects
musculoskeletal diseases
Abstract

Background: Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator of Nuclear Factor kB (sRANKL) and OPG concentrations in women are limited. We evaluated reproductive and lifestyle factors as potential sources of variation in circulating sRANKL and OPG concentrations in pre- and postmenopausal women. Methods: This study includes 2,016 controls [n = 1,552 (76%) postmenopausal, n = 757 (38%) using postmenopausal hormone therapy (PMH)] from a breast cancer case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Serum sRANKL was measured using an ELISA and serum OPG using an electrochemiluminescent assay. Generalized linear models were used to evaluate associations between these analytes and reproductive and lifestyle factors. Results: Older age at blood collection was associated with lower sRANKL concentrations in postmenopausal women (Ptrend < 0.03) and higher OPG concentrations in all women (Ptrend < 0.01). Longer duration of oral contraceptive use among premenopausal women and postmenopausal PMH users was associated with higher OPG (Ptrend < 0.04). In postmenopausal non-PMH users, sRANKL concentrations were lower with longer duration of oral contraceptive use and current (vs. never) smoking (P < 0.01). sRANKL concentrations were higher among women with higher BMI (Ptrend < 0.01). The evaluated factors accounted for 12% of the variation in sRANKL concentrations and 21% of the variation in OPG concentrations. Conclusions: Circulating sRANKL and OPG concentrations are minimally impacted by hormone-related factors in pre- and postmenopausal women. Impact: This study suggests circulating concentrations of sRANKL and OPG are unlikely to be strongly modified by hormone-related reproductive and lifestyle factors. © 2019 American Association for Cancer Research.

Published
2019

36. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Karavasiloglou, N. Hüsing, A. Masala, G. Van Gils, C.H. Turzanski Fortner, R. Chang-Claude, J. Huybrechts, I. Weiderpass, E. Gunter, M. Arveux, P. Fournier, A. Kvaskoff, M. Tjønneland, A. Kyrø, C. Dahm, C.C. Vistisen, H.T. Bakker, M.F. Sánchez, M.-J. Chirlaque López, M.D. Santiuste, C. Ardanaz, E. Menéndez, V. Agudo, A. Trichopoulou, A. Karakatsani, A. La Vecchia, C. Peppa, E. Palli, D. Agnoli, C. Panico, S. Tumino, R. Sacerdote, C. Butt, S.T. Borgquist, S. Skeie, G. Schulze, M. Key, T. Khaw, K.-T. Tsilidis, K.K. Ellingjord-Dale, M. Riboli, E. Kaaks, R. Dossus, L. Rohrmann, S. Kühn, T.

Abstract

Background: Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some established risk factors for invasive breast cancer have a similar impact on BCIS risk, but large population-based studies on lifestyle factors and BCIS risk are lacking. Thus, we investigated the association between lifestyle and BCIS risk within the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Lifestyle was operationalized by a score reflecting the adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations. The recommendations utilized in these analyses were the ones pertinent to healthy body weight, physical activity, consumption of plant-based foods, energy-dense foods, red and processed meat, and sugary drinks and alcohol, as well as the recommendation on breastfeeding. Cox proportional hazards regression was used to assess the association between lifestyle score and BCIS risk. The results were presented as hazard ratios (HR) and corresponding 95% confidence intervals (CI). Results: After an overall median follow-up time of 14.9 years, 1277 BCIS cases were diagnosed. Greater adherence to the WCRF/AICR cancer prevention recommendations was not associated with BCIS risk (HR = 0.98, 95% CI 0.93-1.03; per one unit of increase; multivariable model). An inverse association between the lifestyle score and BCIS risk was observed in study centers, where participants were recruited mainly via mammographic screening and attended additional screening throughout follow-up (HR = 0.85, 95% CI 0.73-0.99), but not in the remaining ones (HR = 0.99, 95% CI 0.94-1.05). Conclusions: While we did not observe an overall association between lifestyle and BCIS risk, our results indicate that lifestyle is associated with BCIS risk among women recruited via screening programs and with regular screening participation. This suggests that a true inverse association between lifestyle habits and BCIS risk in the overall cohort may have been masked by a lack of information on screening attendance. The potential inverse association between lifestyle and BCIS risk in our analyses is consistent with the inverse associations between lifestyle scores and breast cancer risk reported from previous studies. © 2019 The Author(s).

Published
2019

39. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S

Author

Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.

Published
2017

40. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi

Author

MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.

Published
2017

42. The influence of anisotropy in numerical modelling of orthogonal cutting of cortical bone

Author

Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials, Ministerio de Ciencia e Innovación, Santiuste, C., Rodríguez Millán, M., Giner Maravilla, Eugenio, Miguélez, H., Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials, Ministerio de Ciencia e Innovación, Santiuste, C., Rodríguez Millán, M., Giner Maravilla, Eugenio, and Miguélez, H.

Abstract

Cutting operations in bone are involved in surgical treatments in orthopaedics and traumatology. The importance of guaranteeing the absence of damage in the living workpiece is equivalent in this case to ensuring surface quality. The knowledge in this field is really far from the expertise in industrial cutting of mechanical components. Modeling of bone cutting is a challenge strongly dependent on the accurate modeling of mechanical behaviour of the bone. This paper focuses on modeling of orthogonal cutting of cortical bone. The intrinsic anisotropic nature of the cortical bone that makes it comparable to a composite material is taken into account. The influence of anisotropy is analysed comparing this behaviour with an isotropic approach. It is shown that both chip morphology and temperature are affected by the anisotropy of the cortical bone that acts as a workpiece.

Published
2014

45. Circulating 25-Hydroxyvitamin D3 in Relation to Renal Cell Carcinoma Incidence and Survival in the EPIC Cohort

Author

Muller, D. C., primary, Fanidi, A., additional, Midttun, O., additional, Steffen, A., additional, Dossus, L., additional, Boutron-Ruault, M.-C., additional, Severi, G., additional, Kuhn, T., additional, Katzke, V., additional, de la Torre, R. A., additional, Gonzalez, C. A., additional, Sanchez, M.-J., additional, Dorronsoro, M., additional, Santiuste, C., additional, Barricarte, A., additional, Khaw, K.-T., additional, Wareham, N., additional, Travis, R. C., additional, Trichopoulou, A., additional, Giotaki, M., additional, Trichopoulos, D., additional, Palli, D., additional, Krogh, V., additional, Tumino, R., additional, Vineis, P., additional, Panico, S., additional, Tjonneland, A., additional, Olsen, A., additional, Bueno-de-Mesquita, H. B., additional, Peeters, P. H., additional, Ljungberg, B., additional, Wennberg, M., additional, Weiderpass, E., additional, Murphy, N., additional, Riboli, E., additional, Ueland, P. M., additional, Boeing, H., additional, Brennan, P., additional, and Johansson, M., additional

Published
2014
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