121 results on '"Santiuste, Carmen"'
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2. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
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Gaziano, Liam, Sun, Luanluan, Arnold, Matthew, Bell, Steven, Cho, Kelly, Kaptoge, Stephen, Song, Rebecca, Burgess, Stephen, Posner, Daniel, Mosconi, Katja, Robinson-Cohen, Cassianne, Mason, Amy, Bolton, Thomas, Tao, Ran, Allara, Elias, Schubert, Petra, Chen, Lingyan, Staley, James, Staplin, Natalie, Altay, Servet, Amiano, Pilar, Arndt, Volker, Ärnlöv, Johan, Barr, Elizabeth, Björkelund, Cecilia, Boer, Jolanda, Brenner, Hermann, Casiglia, Edoardo, Chiodini, Paolo, Cooper, Jackie, Coresh, Josef, Cushman, Mary, Dankner, Rachel, Davidson, Karina, de Jongh, Renate, Donfrancesco, Chiara, Engström, Gunnar, Freisling, Heinz, de la Cámara, Agustín, Gudnason, Vilmundur, Hankey, Graeme, Hansson, Per-Olof, Heath, Alicia, Hoorn, Ewout, Imano, Hironori, Jassal, Simerjot, Kaaks, Rudolf, Katzke, Verena, Kauhanen, Jussi, Kiechl, Stefan, Koenig, Wolfgang, Kronmal, Richard, Kyrø, Cecilie, Lawlor, Deborah, Ljungberg, Börje, MacDonald, Conor, Masala, Giovanna, Meisinger, Christa, Melander, Olle, Moreno Iribas, Conchi, Ninomiya, Toshiharu, Nitsch, Dorothea, Nordestgaard, Børge, Onland-Moret, Charlotte, Palmieri, Luigi, Petrova, Dafina, Garcia, Jose, Rosengren, Annika, Sacerdote, Carlotta, Sakurai, Masaru, Santiuste, Carmen, Schulze, Matthias, Sieri, Sabina, Sundström, Johan, Tikhonoff, Valérie, Tjønneland, Anne, Tong, Tammy, Tumino, Rosario, Tzoulaki, Ioanna, van der Schouw, Yvonne, Monique Verschuren, W, Völzke, Henry, Wallace, Robert, Wannamethee, S, Weiderpass, Elisabete, Willeit, Peter, Woodward, Mark, Yamagishi, Kazumasa, Zamora-Ros, Raul, Akwo, Elvis, Pyarajan, Saiju, Gagnon, David, Tsao, Philip, Muralidhar, Sumitra, Edwards, Todd, Damrauer, Scott, Joseph, Jacob, Pennells, Lisa, Wilson, Peter, and Harrison, Seamus
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cardiovascular diseases ,coronary disease ,kidney diseases ,stroke ,Humans ,Mendelian Randomization Analysis ,Prospective Studies ,Cardiovascular Diseases ,Coronary Disease ,Risk Factors ,Diabetes Mellitus ,Stroke ,Kidney - Abstract
BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values 105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR 105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.
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- 2022
3. High adherence to Western dietary pattern increases breast cancer risk (an EPIC-Spain study)
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Castelló, Adela, Rodríguez-Barranco, Miguel, Lope, Virginia, Guevara, Marcela, Colorado-Yohar, Sandra, Dorronsoro, Ane, Quirós, José Ramón, Castro-Espin, Carlota, Sayon-Orea, Carmen, Santiuste, Carmen, Amiano, Pilar, Lasheras, Cristina, Sanchez, María-José, and Pollán, Marina
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- 2024
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4. Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
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Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure
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- 2022
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5. Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study
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Iglesias-Vázquez, Lucía, Arija, Victoria, Aranda, Núria, Aglago, Elom K., Cross, Amanda J., Schulze, Matthias B., Quintana Pacheco, Daniel, Kühn, Tilman, Weiderpass, Elisabete, Tumino, Rosario, Redondo-Sánchez, Daniel, de Magistris, Maria Santucci, Palli, Domenico, Ardanaz, Eva, Laouali, Nasser, Sonestedt, Emily, Drake, Isabel, Rizzolo, Lucía, Santiuste, Carmen, Sacerdote, Carlotta, Quirós, Ramón, Amiano, Pilar, Agudo, Antonio, and Jakszyn, Paula
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- 2022
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6. Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults.
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Debras, Charlotte, Cordova, Reynalda, Mayén, Ana-Lucia, Maasen, Kim, Knaze, Viktoria, Eussen, Simone J. P. M., Schalkwijk, Casper G., Huybrechts, Inge, Tjønneland, Anne, Halkjær, Jytte, Katzke, Verena, Bajracharya, Rashmita, Schulze, Matthias B., Masala, Giovanna, Pala, Valeria, Pasanisi, Fabrizio, Macciotta, Alessandra, Petrova, Dafina, Castañeda, Jazmin, and Santiuste, Carmen
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OBESITY risk factors ,FOOD consumption ,BODY mass index ,RESEARCH funding ,ALDEHYDES ,BODY weight ,SEX distribution ,MULTIPLE regression analysis ,AGE distribution ,DESCRIPTIVE statistics ,LONGITUDINAL method ,ADVANCED glycation end-products ,ANTHROPOMETRY ,CONFIDENCE intervals ,WEIGHT gain ,REGRESSION analysis - Abstract
Dicarbonyl compounds are highly reactive precursors of advanced glycation end products (AGE), produced endogenously, present in certain foods and formed during food processing. AGE contribute to the development of adverse metabolic outcomes, but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO) and 3-deoxyglucosone (3-DG), and body weight changes in European adults. Dicarbonyl intakes were estimated using food composition database from 263 095 European Prospective Investigation into Cancer and Nutrition–Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home in Relation to Anthropometry participants with two body weight assessments (median follow-up time = 5·4 years). Associations between dicarbonyls and 5-year body-weight changes were estimated using mixed linear regression models. Stratified analyses by sex, age and baseline BMI were performed. Risk of becoming overweight/obese was assessed using multivariable-adjusted logistic regression. MGO intake was associated with 5-year body-weight gain of 0·089 kg (per 1-sd increase, 95 % CI 0·072, 0·107). 3-DG was inversely associated with body-weight change (–0·076 kg, −0·094, −0·058). No significant association was observed for GO (0·018 kg, −0·002, 0·037). In stratified analyses, GO was associated with body-weight gain among women and older participants (above median of 52·4 years). MGO was associated with higher body-weight gain among older participants. 3-DG was inversely associated with body-weight gain among younger and normal-weight participants. MGO was associated with a higher risk of becoming overweight/obese, while inverse associations were observed for 3-DG. No associations were observed for GO with overweight/obesity. Dietary dicarbonyls are inconsistently associated with body weight change among European adults. Further research is needed to clarify the role of these food components in overweight and obesity, their underlying mechanisms and potential public health implications. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
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Rinaldi, Sabina, primary, Dossus, Laure, additional, Keski‐Rahkonen, Pekka, additional, Kiss, Agneta, additional, Navionis, Anne‐Sophie, additional, Biessy, Carine, additional, Travis, Ruth, additional, Weiderpass, Elisabete, additional, Romieu, Isabelle, additional, Eriksen, Anne Kirstine, additional, Tjonneland, Anne, additional, Kvaskoff, Marina, additional, Canonico, Marianne, additional, Truong, Thérèse, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Catalano, Alberto, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Lukic, Marko, additional, Olsen, Karina Standahl, additional, Zamora‐Ros, Raul, additional, Santiuste, Carmen, additional, Aizpurua Atxega, Amaia, additional, Guevara, Marcela, additional, Rodriguez‐Barranco, Miguel, additional, Sandstrom, Maria, additional, Hennings, Joakim, additional, Almquist, Martin, additional, Aglago Kouassivi, Elom, additional, Christakoudi, Sofia, additional, Gunter, Marc, additional, and Franceschi, Silvia, additional
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- 2024
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8. A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
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Papadimitriou, Nikos, Muller, David, van den Brandt, Piet A., Geybels, Milan, Patel, Chirag J., Gunter, Marc J., Lopez, David S., Key, Timothy J., Perez-Cornago, Aurora, Ferrari, Pietro, Vineis, Paolo, Weiderpass, Elisabete, Boeing, Heiner, Agudo, Antonio, Sánchez, María-José, Overvad, Kim, Kühn, Tilman, Fortner, Renee T., Palli, Domenico, Drake, Isabel, Bjartell, Anders, Santiuste, Carmen, Bueno-de-Mesquita, Bas H., Krogh, Vittorio, Tjønneland, Anne, Lauritzen, Dorthe Furstrand, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Stattin, Pär, Trichopoulou, Antonia, Martimianaki, Georgia, Karakatsani, Anna, Thysell, Elin, Johansson, Ingegerd, Ricceri, Fulvio, Tumino, Rosario, Larrañaga, Nerea, Khaw, Kay Tee, Riboli, Elio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K.
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- 2020
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9. The ERA Registry Annual Report 2020: a summary
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Astley, Megan E, primary, Boenink, Rianne, additional, ElHafeez, Samar Abd, additional, Trujillo-Alemán, Sara, additional, Arribas, F, additional, Åsberg, Anders, additional, Beckerman, Pazit, additional, Bell, Samira, additional, Bouzas-Caamaño, María Encarnación, additional, Farnés, Jordi Comas, additional, Galvão, Ana Amélia, additional, Gjorgjievski, Nikola, additional, Kelmendi, Vjollca Godanci, additional, Guidotti, Rebecca, additional, Helve, Jaakko, additional, Idrizi, Alma, additional, Indriðason, Ólafur S, additional, Ioannou, Kyriakos, additional, Kerschbaum, Julia, additional, Komissarov, Kirill, additional, Castro de la Nuez, Pablo, additional, Lassalle, Mathilde, additional, Nordio, Maurizio, additional, Arévalo, Olga Lucía Rodríguez, additional, Santiuste, Carmen, additional, Seyahi, Nurhan, additional, Roblero, María Fernanda Slon, additional, Steenkamp, Retha, additional, ten Dam, Marc A G J, additional, Zakharova, Elena V, additional, Ziginskiene, Edita, additional, Bonthuis, Marjolein, additional, Stel, Vianda S, additional, Ortiz, Alberto, additional, Jager, Kitty J, additional, and Kramer, Anneke, additional
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- 2023
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10. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
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Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S., Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C., Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y. N., Schmidt, Julie A., Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H. Susan J., Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J., Gunter, Marc J., and Ferrari, Pietro
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- 2020
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11. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Karavasiloglou, Nena, Hüsing, Anika, Masala, Giovanna, van Gils, Carla H., Turzanski Fortner, Renée, Chang-Claude, Jenny, Huybrechts, Inge, Weiderpass, Elisabete, Gunter, Marc, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Tjønneland, Anne, Kyrø, Cecilie, Dahm, Christina C., Vistisen, Helene Tilma, Bakker, Marije F., Sánchez, Maria-Jose, Chirlaque López, María Dolores, Santiuste, Carmen, Ardanaz, Eva, Menéndez, Virginia, Agudo, Antonio, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Butt, Salma Tunå, Borgquist, Signe, Skeie, Guri, Schulze, Matthias, Key, Timothy, Khaw, Kay-Tee, Tsilidis, Kostantinos K., Ellingjord-Dale, Merete, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rohrmann, Sabine, and Kühn, Tilman
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- 2019
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12. Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition
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Macciotta, Alessandra, primary, Catalano, Alberto, additional, Giraudo, Maria Teresa, additional, Weiderpass, Elisabete, additional, Ferrari, Pietro, additional, Freisling, Heinz, additional, Colorado-Yohar, Sandra M., additional, Santiuste, Carmen, additional, Amiano, Pilar, additional, Heath, Alicia K., additional, Ward, Heather A., additional, Christakoudi, Sofia, additional, Vineis, Paolo, additional, Singh, Deependra, additional, Vaccarella, Salvatore, additional, Schulze, Matthias B., additional, Hiensch, Anouk E., additional, Monninkhof, Evelyn M., additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Tumino, Rosario, additional, Lazzarato, Fulvio, additional, Milani, Lorenzo, additional, Agudo, Antonio, additional, Dahm, Christina C., additional, Baglietto, Laura, additional, Perduca, Vittorio, additional, Severi, Gianluca, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Ardanaz, Eva, additional, Borch, Kristin B., additional, Benebo, Faith O., additional, Braaten, Tonje, additional, Sánchez, Maria-Jose, additional, Giachino, Claudia, additional, Sacerdote, Carlotta, additional, and Ricceri, Fulvio, additional
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- 2022
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13. Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort
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Claeys, Liesel, primary, De Saeger, Sarah, additional, Scelo, Ghislaine, additional, Biessy, Carine, additional, Casagrande, Corinne, additional, Nicolas, Genevieve, additional, Korenjak, Michael, additional, Fervers, Beatrice, additional, Heath, Alicia K., additional, Krogh, Vittorio, additional, Luján-Barroso, Leila, additional, Castilla, Jesús, additional, Ljungberg, Börje, additional, Rodriguez-Barranco, Miguel, additional, Ericson, Ulrika, additional, Santiuste, Carmen, additional, Catalano, Alberto, additional, Overvad, Kim, additional, Brustad, Magritt, additional, Gunter, Marc J., additional, Zavadil, Jiri, additional, De Boevre, Marthe, additional, and Huybrechts, Inge, additional
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- 2022
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14. Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization
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Dam, Veerle, Onland-Moret, N. Charlotte, Burgess, Stephen, Chirlaque, Maria Dolores, Peters, Sanne A.E., Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M., Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Rualt, Marie-Christine, Schulze, Matthias B., Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M. A., Verschuren, W.M. Monique, Waaseth, Marit, Pérez, María José Sánchez, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J., Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J., Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E., Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, McPherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S., and van der Schouw, Yvonne T.
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Mendelian Randomization ,Reproductive aging ,coronary heart disease ,risk factors ,cardiovascular diseases - Abstract
Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.
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- 2022
15. Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition ( EPIC ) study
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Clasen, Joanna L, primary, Heath, Alicia K, additional, Van Puyvelde, Heleen, additional, Huybrechts, Inge, additional, Park, Jin Young, additional, Ferrari, Pietro, additional, Scelo, Ghislaine, additional, Ulvik, Arve, additional, Midttun, Øivind, additional, Ueland, Per Magne, additional, Overvad, Kim, additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Chiodini, Paolo, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Zamora‐Ros, Raul, additional, Rodriguez‐Barranco, Miguel, additional, Santiuste, Carmen, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Schmidt, Julie A, additional, Weiderpass, Elisabete, additional, Gunter, Marc, additional, Riboli, Elio, additional, Cross, Amanda J, additional, Johansson, Mattias, additional, and Muller, David C, additional
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- 2022
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16. Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization
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Dam, Veerle, primary, Onland-Moret, N Charlotte, additional, Burgess, Stephen, additional, Chirlaque, Maria-Dolores, additional, Peters, Sanne A E, additional, Schuit, Ewoud, additional, Tikk, Kaja, additional, Weiderpass, Elisabete, additional, Oliver-Williams, Clare, additional, Wood, Angela M, additional, Tjønneland, Anne, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Schulze, Matthias B, additional, Trichopoulou, Antonia, additional, Ferrari, Pietro, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Matullo, Giuseppe, additional, Panico, Salvatore, additional, Boer, Jolanda M A, additional, Verschuren, W M Monique, additional, Waaseth, Marit, additional, Pérez, Maria José Sánchez, additional, Amiano, Pilar, additional, Imaz, Liher, additional, Moreno-Iribas, Conchi, additional, Melander, Olle, additional, Harlid, Sophia, additional, Nordendahl, Maria, additional, Wennberg, Patrik, additional, Key, Timothy J, additional, Riboli, Elio, additional, Santiuste, Carmen, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Langenberg, Claudia, additional, Wareham, Nicholas J, additional, Schunkert, Heribert, additional, Erdmann, Jeanette, additional, Willenborg, Christina, additional, Hengstenberg, Christian, additional, Kleber, Marcus E, additional, Delgado, Graciela, additional, März, Winfried, additional, Kanoni, Stavroula, additional, Dedoussis, George, additional, Deloukas, Panos, additional, Nikpay, Majid, additional, McPherson, Ruth, additional, Scholz, Markus, additional, Teren, Andrej, additional, Butterworth, Adam S, additional, and van der Schouw, Yvonne T, additional
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- 2022
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17. Additional file 1 of Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
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Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure
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skin and connective tissue diseases - Abstract
Additional file 1: Circulating inflammatory biomarkers and breast cancer risk in the EPIC prospective study: Supplementary Tables S1- S7 and Figures S1-S3. Table S1. Geometric mean values for inflammatory biomarkers in breast cancer cases and matched controls. Table S2. Associations between inflammatory biomarkers and breast cancer risk by age at diagnosis. Table S3. Associations between inflammatory biomarkers and breast cancer risk by breast cancer molecular subtypes. Table S4. Associations between inflammatory biomarkers and breast cancer risk by time between blood collection and diagnosis. Table S5. Associations between inflammatory biomarkers and breast cancer risk by body mass index. Table S6. Associations between inflammatory biomarkers and breast cancer risk by waist circumference. Table S7. Associations between inflammatory biomarkers and breast cancer risk among non-hormone users at blood collection. Table S8. Associations between IL-10 and breast cancer risk overall and according to menopausal status at blood collection, after excluding women with values of IL-10 below the LOQ. Table S9. Associations between TNF-α and breast cancer risk overall and according to menopausal status at blood collection, after excluding women with values of TNF-α below the LOQ. Figure S1. Flow chart of the study population. Figure S2. Association between leptin and breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline). Figure S3. Association between leptin-to-adiponectin ratio and breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline). Figure S4. Association between CRP with breast cancer risk, overall and by menopausal status, allowing for nonlinear effects (restricted cubic spline).
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- 2022
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18. Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition.
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Macciotta, Alessandra, Catalano, Alberto, Giraudo, Maria Teresa, Weiderpass, Elisabete, Ferrari, Pietro, Freisling, Heinz, Colorado-Yohar, Sandra M., Santiuste, Carmen, Amiano, Pilar, Heath, Alicia K., Ward, Heather A., Christakoudi, Sofia, Vineis, Paolo, Singh, Deependra, Vaccarella, Salvatore, Schulze, Matthias B., Hiensch, Anouk E., Monninkhof, Evelyn M., Katzke, Verena, and Kaaks, Rudolf
- Abstract
Background: Many studies have shown that socioeconomic position (SEP) is associated with the incidence of malignant tumors at different sites. This study aims to estimate the association between educational level (as proxy for SEP) and cancer incidence and to understand whether the observed associations might be partially explained by lifestyle behaviors. Methods: The analyses were performed on data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, globally and by sex. We used Cox proportional hazards models together with mediation analysis to disentangle the total effect (TE) of educational level [measured through the Relative Index of Inequality (RII)] on cancer incidence into pure direct (PDE) and total indirect (TIE) effect, unexplained and explained by mediators, respectively. PDE and TIE were then combined to compute the proportions mediated (PM). Results: After an average of 14 years of follow-up, 52,422 malignant tumors were ascertained. Low educated participants showed higher risk of developing stomach, lung, kidney (in women), and bladder (in men) cancers, and, conversely, lower risk of melanoma and breast cancer (in post-menopausal women), when compared with more educated participants. Mediation analyses showed that portions of the TE of RII on cancer could be explained by site-specific related lifestyle behaviors for stomach, lung, and breast (in women). Conclusions: Cancer incidence in Europe is determined at least in part by a socioeconomically stratified distribution of risk factors. Impact: These observational findings support policies to reduce cancer occurrence by altering mediators, such as lifestyle behaviors, particularly focusing on underprivileged strata of the population. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC‐CVD Case‐Cohort Study Across Nine European Countries
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Steur, Marinka, primary, Johnson, Laura, additional, Sharp, Stephen J., additional, Imamura, Fumiaki, additional, Sluijs, Ivonne, additional, Key, Timothy J., additional, Wood, Angela, additional, Chowdhury, Rajiv, additional, Guevara, Marcela, additional, Jakobsen, Marianne U., additional, Johansson, Ingegerd, additional, Koulman, Albert, additional, Overvad, Kim, additional, Sánchez, Maria‐José, additional, van der Schouw, Yvonne T., additional, Trichopoulou, Antonia, additional, Weiderpass, Elisabete, additional, Wennberg, Maria, additional, Zheng, Ju‐Sheng, additional, Boeing, Heiner, additional, Boer, Jolanda M. A., additional, Boutron‐Ruault, Marie‐Christine, additional, Ericson, Ulrika, additional, Heath, Alicia K., additional, Huybrechts, Inge, additional, Imaz, Liher, additional, Kaaks, Rudolf, additional, Krogh, Vittorio, additional, Kühn, Tilman, additional, Kyrø, Cecilie, additional, Masala, Giovanna, additional, Melander, Olle, additional, Moreno‐Iribas, Conchi, additional, Panico, Salvatore, additional, Quirós, José R., additional, Rodríguez‐Barranco, Miguel, additional, Sacerdote, Carlotta, additional, Santiuste, Carmen, additional, Skeie, Guri, additional, Tjønneland, Anne, additional, Tumino, Rosario, additional, Verschuren, W. M. Monique, additional, Zamora‐Ros, Raul, additional, Dahm, Christina C., additional, Perez‐Cornago, Aurora, additional, Schulze, Matthias B., additional, Tong, Tammy Y. N., additional, Riboli, Elio, additional, Wareham, Nicholas J., additional, Danesh, John, additional, Butterworth, Adam S., additional, and Forouhi, Nita G., additional
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- 2021
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20. Bone mineral density decline according to renal tubular dysfunction and phosphaturia in tenofovir-exposed HIV-infected patients
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Casado, José L., Santiuste, Carmen, Vazquez, Monica, Bañón, Sara, Rosillo, Marta, Gomez, Ana, Perez-Elías, María J., Caballero, Carmen, Rey, José M., and Moreno, Santiago
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- 2016
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21. Prevalence and significance of proximal renal tubular abnormalities in HIV-infected patients receiving tenofovir
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Casado, José L., Bañón, Sara, Santiuste, Carmen, Serna, Jorge, Guzman, Paula, Tenorio, Maite, Liaño, Fernando, and del Rey, José M
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- 2016
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22. Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC)
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Wozniak, Magdalena B., Brennan, Paul, Brenner, Darren R., Overvad, Kim, Olsen, Anja, Tjnneland, Anne, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Bergmann, Manuela M., Steffen, Annika, Naska, Androniki, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Saieva, Calogero, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Hjartåker, Anette, Weiderpass, Elisabete, Arriola, Larraitz, Molina-Montes, Esther, Duell, Eric J., Santiuste, Carmen, de la Torre, Ramón Alonso, Gurrea, Aurelio Barricarte, Stocks, Tanja, Johansson, Mattias, Ljungberg, Börje, Wareham, Nick, Khaw, Kay-Tee, Travis, Ruth C., Cross, Amanda J., Murphy, Neil, Riboli, Elio, and Scelo, Ghislaine
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- 2015
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23. Risk and outcomes of COVID‐19 in patients with multiple sclerosis
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Moreno‐Torres, Irene, primary, Meca Lallana, Virginia, additional, Costa‐Frossard, Lucienne, additional, Oreja‐Guevara, Celia, additional, Aguirre, Clara, additional, Alba Suárez, Elda María, additional, Gómez Moreno, Mayra, additional, Borrega Canelo, Laura, additional, Sabín Muñoz, Julia, additional, Aladro, Yolanda, additional, Cárcamo, Alba, additional, Rodríguez García, Elena, additional, Cuello, Juan Pablo, additional, Monreal, Enric, additional, Sainz de la Maza, Susana, additional, Pérez Parra, Fernando, additional, Valenzuela Rojas, Francisco, additional, López de Silanes de Miguel, Carlos, additional, Casanova, Ignacio, additional, Martínez Gines, Maria Luisa, additional, Blasco, Rosario, additional, Orviz García, Aida, additional, Villar‐Guimerans, Luisa María, additional, Fernández‐Dono, Guillermo, additional, Elvira, Víctor, additional, Santiuste, Carmen, additional, Espiño, Mercedes, additional, and García Domínguez, José Manuel, additional
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- 2021
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24. Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study
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Iglesias-Vázquez, Lucía, primary, Arija, Victoria, additional, Aranda, Núria, additional, Aglago, Elom K., additional, Cross, Amanda J., additional, Schulze, Matthias B., additional, Quintana Pacheco, Daniel, additional, Kühn, Tilman, additional, Weiderpass, Elisabete, additional, Tumino, Rosario, additional, Redondo-Sánchez, Daniel, additional, de Magistris, Maria Santucci, additional, Palli, Domenico, additional, Ardanaz, Eva, additional, Laouali, Nasser, additional, Sonestedt, Emily, additional, Drake, Isabel, additional, Rizzolo, Lucía, additional, Santiuste, Carmen, additional, Sacerdote, Carlotta, additional, Quirós, Ramón, additional, Amiano, Pilar, additional, Agudo, Antonio, additional, and Jakszyn, Paula, additional
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- 2021
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25. Efficacy of dual therapy with lamivudine plus darunavir boosted with ritonavir once daily in HIV-infected patients with nucleoside analogue toxicity
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Casado, José L., Bañón, Sara, Rodriguez, Miguel A., Santiuste, Carmen, Perez-Elías, María J., Moreno, Ana, and Moreno, Santiago
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- 2015
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26. Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Ellingjord-Dale, Merete, Christakoudi, Sofia, Weiderpass, Elisabete, Panico, Salvatore, Dossus, Laure, Olsen, Anja, Tjonneland, Anne, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Gram, Inger T., Skeie, Guri, Rosendahl, Ann H., Sund, Malin, Key, Tim, Ferrari, Pietro, Gunter, Marc, Heath, Alicia K., Tsilidis, Konstantinos K., Riboli, Elio, Jose Sanchez, Maria, Chirlaque Lopez, Maria Dolores, Peppa, Eleni, Trichopoulou, Antonia, Martimianaki, Georgia, Agudo, Antonio, Santiuste, Carmen, Ardanaz, Eva, Amiano, Pilar, Boutron-Ruault, Marie-Christine, Simeon, Vittorio, Berrino, Franco, Tumino, Rosario, Severi, Gianluca, Stocks, Tanja, Turzanski-Fortner, Renee, Aleksandrova, Krasimira, Rylander, Charlotta, Aune, Dagfinn, Dahm, Christina C., Department of Surgery, and HUS Abdominal Center
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0301 basic medicine ,Epidemiology ,medicine.medical_treatment ,Weight Gain ,Body Mass Index ,0302 clinical medicine ,Risk Factors ,Prospective Studies ,skin and connective tissue diseases ,Public, Environmental & Occupational Health ,2. Zero hunger ,Obstetrics ,Hazard ratio ,0104 Statistics ,Hormone replacement therapy (menopause) ,General Medicine ,Middle Aged ,EARLY ADULTHOOD ,3142 Public health care science, environmental and occupational health ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Additional Authors ,long-term weight change ,POSTMENOPAUSAL WOMEN ,030220 oncology & carcinogenesis ,OBESITY ,Obesitat ,Female ,medicine.symptom ,Life Sciences & Biomedicine ,Cohort study ,Adult ,medicine.medical_specialty ,MENOPAUSE ,Breast Neoplasms ,SEX STEROIDS ,Càncer de mama ,1117 Public Health and Health Services ,Young Adult ,03 medical and health sciences ,Breast cancer ,breast cancer ,BODY FATNESS ,medicine ,cohort study ,Humans ,AcademicSubjects/MED00860 ,VALIDITY ,Science & Technology ,OVERWEIGHT ,business.industry ,Kirurgi ,Weight change ,ANTHROPOMETRIC MEASURES ,medicine.disease ,030104 developmental biology ,Surgery ,GAIN ,business ,Weight gain ,Body mass index - Abstract
The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Kræftens Bekæmpelse) (Denmark), German Cancer Aid (Deutsche Krebshilfe), German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Federal Ministry of Education and Research (Bundesministerium fu¨ r Bildung und Forschung, BMBF) (Germany), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Swedish Cancer Society (Cancerfonden), Swedish Research Council (Vetenskapsra° det), County Councils of Ska°ne and Va¨sterbotten (Sweden), Cancer Research UK (14136 to EPIC-Norfolk; C570/ A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPICOxford) (UK). Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC). The funders had no role in the design and conduct of the study; the collection, analysis and interpretation of the data; or the preparation, review and approval of the manuscript; or in the decision to submit the manuscript for publication., Background: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status. Methods: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer. Results: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation¼3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (62.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR)¼1.42; 95% confidence interval 1.22–1.65] in ever HRT users (HR¼1.23; 1.04–1.44), in never HRT users (HR¼1.40; 1.16–1.68) and in oestrogen-and-progesterone-receptor-positive (ERþPRþ) breast cancer (HR¼1.46; 1.15–1.85). Conclusion: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer., European Commission (DG-SANCO), International Agency for Research on Cancer, Danish Cancer Society (Kraftens Bekampelse), German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council, Swedish Cancer Society, Swedish Research Council, County Councils of Skane and Vasterbotten, 14136 Cancer Research UK, C570/A16491 EPIC-Norfolk, 1000143 Medical Research Council, Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC)
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- 2021
27. Circulating 25-Hydroxyvitamin D3 in Relation to Renal Cell Carcinoma Incidence and Survival in the EPIC Cohort
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Muller, David C., Fanidi, Anouar, Midttun, Øivind, Steffen, Annika, Dossus, Laure, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Kühn, Tilman, Katzke, Verena, de la Torre, Ramón Alonso, González, Carlos A., Sánchez, María-José, Dorronsoro, Miren, Santiuste, Carmen, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Trichopoulou, Antonia, Giotaki, Maria, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Tjønneland, Anne, Olsen, Anja, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Ljungberg, Börje, Wennberg, Maria, Weiderpass, Elisabete, Murphy, Neil, Riboli, Elio, Ueland, Per Magne, Boeing, Heiner, Brennan, Paul, and Johansson, Mattias
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- 2014
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28. Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition
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Heath, Alicia K., primary, Clasen, Joanna L., additional, Jayanth, Nick P., additional, Jenab, Mazda, additional, Tjønneland, Anne, additional, Petersen, Kristina Elin Nielsen, additional, Overvad, Kim, additional, Srour, Bernard, additional, Katzke, Verena, additional, Bergmann, Manuela M., additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Catalano, Alberto, additional, Pasanisi, Fabrizio, additional, Brustad, Magritt, additional, Olsen, Karina Standahl, additional, Skeie, Guri, additional, Luján-Barroso, Leila, additional, Rodríguez-Barranco, Miguel, additional, Amiano, Pilar, additional, Santiuste, Carmen, additional, Barricarte Gurrea, Aurelio, additional, Axelson, Håkan, additional, Ramne, Stina, additional, Ljungberg, Börje, additional, Watts, Eleanor L., additional, Huybrechts, Inge, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, and Muller, David C., additional
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- 2021
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29. Risk Prediction for Renal Cell Carcinoma: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study
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Singleton, Rosie K., primary, Heath, Alicia K., additional, Clasen, Joanna L., additional, Scelo, Ghislaine, additional, Johansson, Mattias, additional, Calvez-Kelm, Florence Le, additional, Weiderpass, Elisabete, additional, Liedberg, Fredrik, additional, Ljungberg, Börje, additional, Harbs, Justin, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Dahm, Christina C., additional, Kaaks, Rudolf, additional, Fortner, Renée T., additional, Panico, Salvatore, additional, Tagliabue, Giovanna, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Gram, Inger T., additional, Santiuste, Carmen, additional, Bonet, Catalina, additional, Rodriguez-Barranco, Miguel, additional, Schulze, Mattias B., additional, Bergmann, Manuela M., additional, Travis, Ruth C., additional, Tzoulaki, Ioanna, additional, Riboli, Elio, additional, and Muller, David C., additional
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- 2021
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30. Copper and Zinc Serum Levels after Derivative Bariatric Surgery: Differences Between Roux-en-Y Gastric Bypass and Biliopancreatic Diversion
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Balsa, José A., Botella-Carretero, José I., Gómez-Martín, Jesús M., Peromingo, Roberto, Arrieta, Francisco, Santiuste, Carmen, Zamarrón, Isabel, and Vázquez, Clotilde
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- 2011
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31. Replacement of red and processed meat with other food sources of protein and the risk of type 2 diabetes in European populations; the EPIC-InterAct study
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Ibsen, Daniel B., primary, Steur, Marinka, primary, Imamura, Fumiaki, primary, Overvad, Kim, primary, Schulze, Matthias B., primary, Bendinelli, Benedetta, primary, Guevara, Marcela, primary, Agudo, Antonio, primary, Amiano, Pilar, primary, Aune, Dagfinn, primary, Barricarte, Aurelio, primary, Ericson, Ulrika, primary, Fagherazzi, Guy, primary, Franks, Paul W., primary, Freisling, Heinz, primary, Quiros, Jose R., primary, Grioni, Sara, primary, Heath, Alicia K., primary, Huybrechts, Inge, primary, Katze, Verena, primary, Laouali, Nasser, primary, Mancini, Francesca, primary, Masala, Giovanna, primary, Olsen, Anja, primary, Papier, Keren, primary, Ramne, Stina, primary, Rolandsson, Olov, primary, Sacerdote, Carlotta, primary, Sánchez, Maria-José, primary, Santiuste, Carmen, primary, Simeon, Vittorio, primary, Spijkerman, Annemieke M.W., primary, Srour, Bernard, primary, Tjønneland, Anne, primary, Tong, Tammy Y.N., primary, Tumino, Rosario, primary, Schouw, Yvonne T. van der, primary, Weiderpass, Elisabete, primary, Wittenbecher, Clemens, primary, Sharp, Stephen J., primary, Riboli, Elio, primary, Forouhi, Nita G., primary, and Wareham, Nick J., primary
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- 2020
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32. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: A Prospective Study in the EPIC Cohort
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Lujan-Barroso, Leila, primary, Botteri, Edoardo, additional, Caini, Saverio, additional, Ljungberg, Börje, additional, Roswall, Nina, additional, Tjønneland, Anne, additional, Bueno-de-Mesquita, Bas, additional, Gram, Inger T., additional, Tumino, Rosario, additional, Kiemeney, Lambertus A., additional, Liedberg, Fredrik, additional, Stocks, Tanja, additional, Gunter, Marc J., additional, Murphy, Neil, additional, Cervenka, Iris, additional, Fournier, Agnès, additional, Kvaskoff, Marina, additional, Häggström, Christel, additional, Overvad, Kim, additional, Lund, Eiliv, additional, Waaseth, Marit, additional, Fortner, Renée Turzanski, additional, Kühn, Tilman, additional, Menéndez, Virginia, additional, Sánchez, Maria-Jose, additional, Santiuste, Carmen, additional, Perez-Cornago, Aurora, additional, Zamora-Ros, Raul, additional, Cross, Amanda J., additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Krogh, Vittorio, additional, Sciannameo, Veronica, additional, Mattiello, Amalia, additional, Panico, Salvatore, additional, van Gils, Carla H., additional, Onland-Moret, N. Charlotte, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Khaw, Kay-Tee, additional, Boeing, Heiner, additional, Weiderpass, Elisabete, additional, and Duell, Eric J., additional
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- 2020
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33. Antibody Responses to Helicobacter pylori and Risk of Developing Colorectal Cancer in a European Cohort
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Butt, Julia, primary, Jenab, Mazda, additional, Pawlita, Michael, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Boutron-Ruault, Marie-Christine, additional, Carbonnel, Franck, additional, Dong, Catherine, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Schulze, Matthias B., additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, La Vecchia, Carlo, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel, additional, Gram, Inger T., additional, Weiderpass, Elisabete, additional, Borch, Kristin Benjaminsen, additional, Quirós, Jose Ramón, additional, Agudo, Antonio, additional, Rodríguez-Barranco, Miguel, additional, Santiuste, Carmen, additional, Ardanaz, Eva, additional, Van Guelpen, Bethany, additional, Harlid, Sophia, additional, Imaz, Liher, additional, Perez-Cornago, Aurora, additional, Gunter, Marc J., additional, Zouiouich, Semi, additional, Park, Jin Young, additional, Riboli, Elio, additional, Cross, Amanda J., additional, Heath, Alicia K., additional, Waterboer, Tim, additional, and Hughes, David J., additional
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- 2020
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34. A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
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Papadimitriou, Nikos, primary, Muller, David, additional, van den Brandt, Piet A., additional, Geybels, Milan, additional, Patel, Chirag J., additional, Gunter, Marc J., additional, Lopez, David S., additional, Key, Timothy J., additional, Perez-Cornago, Aurora, additional, Ferrari, Pietro, additional, Vineis, Paolo, additional, Weiderpass, Elisabete, additional, Boeing, Heiner, additional, Agudo, Antonio, additional, Sánchez, María-José, additional, Overvad, Kim, additional, Kühn, Tilman, additional, Fortner, Renee T., additional, Palli, Domenico, additional, Drake, Isabel, additional, Bjartell, Anders, additional, Santiuste, Carmen, additional, Bueno-de-Mesquita, Bas H., additional, Krogh, Vittorio, additional, Tjønneland, Anne, additional, Lauritzen, Dorthe Furstrand, additional, Gurrea, Aurelio Barricarte, additional, Quirós, José Ramón, additional, Stattin, Pär, additional, Trichopoulou, Antonia, additional, Martimianaki, Georgia, additional, Karakatsani, Anna, additional, Thysell, Elin, additional, Johansson, Ingegerd, additional, Ricceri, Fulvio, additional, Tumino, Rosario, additional, Larrañaga, Nerea, additional, Khaw, Kay Tee, additional, Riboli, Elio, additional, Tzoulaki, Ioanna, additional, and Tsilidis, Konstantinos K., additional
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- 2019
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35. Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women: Results from the EPIC Cohort
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Sarink, Danja, primary, Yang, Jiaxi, additional, Johnson, Theron, additional, Chang-Claude, Jenny, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Fournier, Agnès, additional, Mancini, Francesca Romana, additional, Kvaskoff, Marina, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Valanou, Elissavet, additional, Agnoli, Claudia, additional, Sacerdote, Carlotta, additional, Masala, Giovanna, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Van Gils, Carla H., additional, Skeie, Guri, additional, Gram, Inger Torhild, additional, Weiderpass, Elisabete, additional, Lujan-Barroso, Leila, additional, Petrova, Dafina, additional, Santiuste, Carmen, additional, Quirós, J. Ramón, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Travis, Ruth C., additional, Gunter, Marc, additional, Dossus, Laure, additional, Christakoudi, Sofia, additional, Kaaks, Rudolf, additional, and Fortner, Renée Turzanski, additional
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- 2019
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36. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition
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Obón‐Santacana, Mireia, primary, Luján‐Barroso, Leila, additional, Freisling, Heinz, additional, Naudin, Sabine, additional, Boutron‐Ruault, Marie‐Christine, additional, Mancini, Francesca Romana, additional, Rebours, Vinciane, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Boeing, Heiner, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Lasheras, Cristina, additional, Rodríguez‐Barranco, Miguel, additional, Amiano, Pilar, additional, Santiuste, Carmen, additional, Ardanaz, Eva, additional, Khaw, Kay‐Thee, additional, Wareham, Nicholas J., additional, Schmidt, Julie A., additional, Aune, Dagfinn, additional, Trichopoulou, Antonia, additional, Thriskos, Paschalis, additional, Peppa, Eleni, additional, Masala, Giovanna, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Bueno‐de‐Mesquita, Bas, additional, Sciannameo, Veronica, additional, Vermeulen, Roel, additional, Sonestedt, Emily, additional, Sund, Malin, additional, Weiderpass, Elisabete, additional, Skeie, Guri, additional, González, Carlos A., additional, Riboli, Elio, additional, and Duell, Eric J., additional
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- 2019
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37. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition.
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Obón‐Santacana, Mireia, Luján‐Barroso, Leila, Freisling, Heinz, Naudin, Sabine, Boutron‐Ruault, Marie‐Christine, Mancini, Francesca Romana, Rebours, Vinciane, Kühn, Tilman, Katzke, Verena, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Lasheras, Cristina, Rodríguez‐Barranco, Miguel, Amiano, Pilar, Santiuste, Carmen, Ardanaz, Eva, Khaw, Kay‐Thee, and Wareham, Nicholas J.
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PANCREATIC intraepithelial neoplasia ,PROPORTIONAL hazards models ,NUTS ,NUTRITION ,SEEDS ,REDUCING diets - Abstract
Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country‐specific dietary questionnaires. After a mean follow‐up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p‐trend = 0.70). Furthermore, no evidence for effect‐measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk. What's new? Environmental and lifestyle factors probably play a major role in the development—or prevention—of pancreatic cancer (PC). For example, might the inclusion of nuts in one's diet reduce the risk of PC? Results of previous studies have been contradictory. In this analysis of data from the large, prospective EPIC study, the authors found no significant protective role for nuts or seeds against PC. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
38. Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC)
- Author
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Wozniak, Magdalena B. Brennan, Paul Brenner, Darren R. and Overvad, Kim Olsen, Anja Tjonneland, Anne Boutron-Ruault, Marie-Christine Clavel-Chapelon, Francoise Fagherazzi, Guy and Katzke, Verena Kuehn, Tilman Boeing, Heiner Bergmann, Manuela M. Steffen, Annika Naska, Androniki Trichopoulou, Antonia Trichopoulos, Dimitrios Saieva, Calogero Grioni, Sara Panico, Salvatore Tumino, Rosario Vineis, Paolo and Bueno-de-Mesquita, H. B(as) Peeters, Petra H. Hjartaker, Anette and Weiderpass, Elisabete Arriola, Larraitz Molina-Montes, Esther Duell, Eric J. Santiuste, Carmen Alonso de la Torre, Ramon Barricarte Gurrea, Aurelio Stocks, Tanja Johansson, Mattias Ljungberg, Borje Wareham, Nick Khaw, Kay-Tee and Travis, Ruth C. Cross, Amanda J. Murphy, Neil Riboli, Elio and Scelo, Ghislaine
- Abstract
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n=931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment versus the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), 0.91 (0.63-1.30), respectively, (p(trend)=0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer. What’s new? Previous studies have indicated that environmental or lifestyle factors may be involved in the etiology of renal cancer, and that moderate alcohol consumption may reduce the risk of this type of cancer. In this very large European study (nearly 500,000 subjects), the authors found that, indeed, total alcohol consumption was inversely associated with renal cancer overall (for all subsites combined), and also with cancers of the renal parenchyma.
- Published
- 2015
39. Changes in Kidney Function and in the Rate of Tubular Dysfunction After Tenofovir Withdrawal or Continuation in HIV-Infected Patients
- Author
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Casado, José L., primary, del Rey, Jose M., additional, Bañón, Sara, additional, Santiuste, Carmen, additional, Rodriguez, Mar, additional, Moreno, Ana, additional, Perez-Elías, María J., additional, Liaño, Fernando, additional, and Moreno, Santiago, additional
- Published
- 2016
- Full Text
- View/download PDF
40. Identification of Reduced Circulating Haptoglobin Concentration as a Biomarker of the Severity of Pulmonary Embolism: A Nontargeted Proteomic Study
- Author
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Insenser, María, primary, Montes-Nieto, Rafael, additional, Martínez-García, M. Ángeles, additional, Durán, Elena Fernandez, additional, Santiuste, Carmen, additional, Gómez, Vicente, additional, Kline, Jeffrey A., additional, Escobar-Morreale, Héctor F., additional, and Jiménez, David, additional
- Published
- 2014
- Full Text
- View/download PDF
41. Differential resolution of inflammation and recovery after renal ischemia–reperfusion injury in Brown Norway compared with Sprague Dawley rats
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Sáenz-Morales, David, primary, Conde, Elisa, additional, Blanco-Sánchez, Ignacio, additional, Ponte, Belen, additional, Aguado-Fraile, Elia, additional, de las Casas, Gonzalo, additional, García-Martos, Maria, additional, Alegre, Laura, additional, Escribese, Maria M., additional, Molina, Ana, additional, Santiuste, Carmen, additional, Liaño, Fernando, additional, and García-Bermejo, Maria-Laura, additional
- Published
- 2010
- Full Text
- View/download PDF
42. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Author
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Karavasiloglou, Nena, Hüsing, Anika, Masala, Giovanna, Van Gils, Carla H, Turzanski Fortner, Renée, Chang-Claude, Jenny, Huybrechts, Inge, Weiderpass, Elisabete, Gunter, Marc, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Tjønneland, Anne, Kyrø, Cecilie, Dahm, Christina C, Vistisen, Helene Tilma, Bakker, Marije F, Sánchez, Maria-Jose, Chirlaque López, María Dolores, Santiuste, Carmen, Ardanaz, Eva, Menéndez, Virginia, Agudo, Antonio, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Butt, Salma Tunå, Borgquist, Signe, Skeie, Guri, Schulze, Matthias, Key, Timothy, Khaw, Kay-Tee, Tsilidis, Kostantinos K, Ellingjord-Dale, Merete, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rohrmann, Sabine, and Kühn, Tilman
- Subjects
Prevention ,In Situ Breast Cancer ,Cohort ,Lifestyle score ,16. Peace & justice ,Lifestyle ,3. Good health - Abstract
BACKGROUND:Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some established risk factors for invasive breast cancer have a similar impact on BCIS risk, but large population-based studies on lifestyle factors and BCIS risk are lacking. Thus, we investigated the association between lifestyle and BCIS risk within the European Prospective Investigation into Cancer and Nutrition cohort. METHODS:Lifestyle was operationalized by a score reflecting the adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations. The recommendations utilized in these analyses were the ones pertinent to healthy body weight, physical activity, consumption of plant-based foods, energy-dense foods, red and processed meat, and sugary drinks and alcohol, as well as the recommendation on breastfeeding. Cox proportional hazards regression was used to assess the association between lifestyle score and BCIS risk. The results were presented as hazard ratios (HR) and corresponding 95% confidence intervals (CI). RESULTS:After an overall median follow-up time of 14.9 years, 1277 BCIS cases were diagnosed. Greater adherence to the WCRF/AICR cancer prevention recommendations was not associated with BCIS risk (HR = 0.98, 95% CI 0.93-1.03; per one unit of increase; multivariable model). An inverse association between the lifestyle score and BCIS risk was observed in study centers, where participants were recruited mainly via mammographic screening and attended additional screening throughout follow-up (HR = 0.85, 95% CI 0.73-0.99), but not in the remaining ones (HR = 0.99, 95% CI 0.94-1.05). CONCLUSIONS:While we did not observe an overall association between lifestyle and BCIS risk, our results indicate that lifestyle is associated with BCIS risk among women recruited via screening programs and with regular screening participation. This suggests that a true inverse association between lifestyle habits and BCIS risk in the overall cohort may have been masked by a lack of information on screening attendance. The potential inverse association between lifestyle and BCIS risk in our analyses is consistent with the inverse associations between lifestyle scores and breast cancer risk reported from previous studies.
43. Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries
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Steur, Marinka, Johnson, Laura, Sharp, Stephen J, Imamura, Fumiaki, Sluijs, Ivonne, Key, Timothy J, Wood, Angela, Chowdhury, Rajiv, Guevara, Marcela, Jakobsen, Marianne U, Johansson, Ingegerd, Koulman, Albert, Overvad, Kim, Sánchez, Maria-José, Van Der Schouw, Yvonne T, Trichopoulou, Antonia, Weiderpass, Elisabete, Wennberg, Maria, Zheng, Ju-Sheng, Boeing, Heiner, Boer, Jolanda MA, Boutron-Ruault, Marie-Christine, Ericson, Ulrika, Heath, Alicia K, Huybrechts, Inge, Imaz, Liher, Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kyrø, Cecilie, Masala, Giovanna, Melander, Olle, Moreno-Iribas, Conchi, Panico, Salvatore, Quirós, José R, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Santiuste, Carmen, Skeie, Guri, Tjønneland, Anne, Tumino, Rosario, Verschuren, WM Monique, Zamora-Ros, Raul, Dahm, Christina C, Perez-Cornago, Aurora, Schulze, Matthias B, Tong, Tammy YN, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, and Forouhi, Nita G
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2. Zero hunger ,saturated fat ,Incidence ,primary prevention ,Fatty Acids ,Coronary Disease ,Nutrients ,Dietary Fats ,3. Good health ,Cohort Studies ,Europe ,nutritional epidemiology ,Food ,Humans ,coronary heart disease ,dietary guidelines - Abstract
Background There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. Methods and Results We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88-0.99]), cheese (HR, 0.98 [95% CI, 0.96-1.00]), and fish (HR, 0.87 [95% CI, 0.75-1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02-1.12]) and butter (HR, 1.02 [95% CI, 1.00-1.04]). Conclusions This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite directions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.
44. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
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Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S., Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C., Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y. N., Schmidt, Julie A., Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H. Susan J., Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J., Gunter, Marc J., and Ferrari, Pietro
- Subjects
2. Zero hunger ,Prevention ,Cancer and cardiometabolic multimorbidity ,Diabetes ,Healthy lifestyle ,Obesity ,Cardiovascular disease ,3. Good health ,Research Article ,Cancer - Abstract
Background: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. Methods: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. Results: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and women with healthy lifestyles. Conclusion: Pre-diagnostic healthy lifestyle behaviours were strongly inversely associated with the risk of cancer and cardiometabolic diseases, and with the prognosis of these diseases by reducing risk of multimorbidity.
45. MOESM1 of Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
- Author
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Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam, Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina, Menéndez, Virginia, Agudo, Antonio, Maria-Jose Sánchez, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio, Tong, Tammy, Schmidt, Julie, Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, H. Picavet, Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Mazda Jenab, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick, Gunter, Marc, and Ferrari, Pietro
- Subjects
3. Good health - Abstract
Additional file 1: Figure S1. Provides the participant flow chart. Figure S2. Transitions to specific cancer and cardio-metabolic multimorbidity patterns. Figure S3. Results of subgroup analyses. Figure S4. CIFs for men and women of 55 years of age. Figure S5. Results of sensitivity analyses. Figure S6. Results for simplified HLI. Figure S7. CIFs for men and women of 55 years of age using the simplified HLI. and Figure S8. CIFs for men and women of 55 years of age for two groups of cancers. Table S1. Scoring of the healthy lifestyle index (HLI) and its simplified version.
46. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Author
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Karavasiloglou, Nena, Hüsing, Anika, Masala, Giovanna, Van Gils, Carla H, Turzanski Fortner, Renée, Chang-Claude, Jenny, Huybrechts, Inge, Weiderpass, Elisabete, Gunter, Marc, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Tjønneland, Anne, Kyrø, Cecilie, Dahm, Christina C, Vistisen, Helene Tilma, Bakker, Marije F, Sánchez, Maria-Jose, Chirlaque López, María Dolores, Santiuste, Carmen, Ardanaz, Eva, Menéndez, Virginia, Agudo, Antonio, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Butt, Salma Tunå, Borgquist, Signe, Skeie, Guri, Schulze, Matthias, Key, Timothy, Khaw, Kay-Tee, Tsilidis, Kostantinos K, Ellingjord-Dale, Merete, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rohrmann, Sabine, and Kühn, Tilman
- Subjects
Male ,Prevention ,Cohort ,Academies and Institutes ,Breast Neoplasms ,Middle Aged ,Lifestyle ,United States ,3. Good health ,Cohort Studies ,Europe ,Nutrition Assessment ,Risk Factors ,Humans ,Female ,Prospective Studies ,In situ breast cancer ,Lifestyle Score - Abstract
BACKGROUND: Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some established risk factors for invasive breast cancer have a similar impact on BCIS risk, but large population-based studies on lifestyle factors and BCIS risk are lacking. Thus, we investigated the association between lifestyle and BCIS risk within the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Lifestyle was operationalized by a score reflecting the adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations. The recommendations utilized in these analyses were the ones pertinent to healthy body weight, physical activity, consumption of plant-based foods, energy-dense foods, red and processed meat, and sugary drinks and alcohol, as well as the recommendation on breastfeeding. Cox proportional hazards regression was used to assess the association between lifestyle score and BCIS risk. The results were presented as hazard ratios (HR) and corresponding 95% confidence intervals (CI). RESULTS: After an overall median follow-up time of 14.9 years, 1277 BCIS cases were diagnosed. Greater adherence to the WCRF/AICR cancer prevention recommendations was not associated with BCIS risk (HR = 0.98, 95% CI 0.93-1.03; per one unit of increase; multivariable model). An inverse association between the lifestyle score and BCIS risk was observed in study centers, where participants were recruited mainly via mammographic screening and attended additional screening throughout follow-up (HR = 0.85, 95% CI 0.73-0.99), but not in the remaining ones (HR = 0.99, 95% CI 0.94-1.05). CONCLUSIONS: While we did not observe an overall association between lifestyle and BCIS risk, our results indicate that lifestyle is associated with BCIS risk among women recruited via screening programs and with regular screening participation. This suggests that a true inverse association between lifestyle habits and BCIS risk in the overall cohort may have been masked by a lack of information on screening attendance. The potential inverse association between lifestyle and BCIS risk in our analyses is consistent with the inverse associations between lifestyle scores and breast cancer risk reported from previous studies.
47. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
- Author
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Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S., Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C., Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y. N., Schmidt, Julie A., Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H. Susan J., Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J., Gunter, Marc J., and Ferrari, Pietro
- Subjects
2. Zero hunger ,Prevention ,Cancer and cardiometabolic multimorbidity ,Diabetes ,Healthy lifestyle ,Obesity ,Cardiovascular disease ,3. Good health ,Research Article ,Cancer - Abstract
Background: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. Methods: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. Results: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and women with healthy lifestyles. Conclusion: Pre-diagnostic healthy lifestyle behaviours were strongly inversely associated with the risk of cancer and cardiometabolic diseases, and with the prognosis of these diseases by reducing risk of multimorbidity.
48. MOESM1 of Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Author
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Karavasiloglou, Nena, Hüsing, Anika, Masala, Giovanna, Gils, Carla Van, Fortner, Renée Turzanski, Chang-Claude, Jenny, Huybrechts, Inge, Weiderpass, Elisabete, Gunter, Marc, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Tjønneland, Anne, Kyrø, Cecilie, Dahm, Christina, Vistisen, Helene, Bakker, Marije F., Maria-Jose Sánchez, López, María Chirlaque, Santiuste, Carmen, Ardanaz, Eva, Menéndez, Virginia, Agudo, Antonio, Trichopoulou, Antonia, Karakatsani, Anna, Vecchia, Carlo La, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Butt, Salma, Borgquist, Signe, Skeie, Guri, Schulze, Matthias, Key, Timothy, Kay-Tee Khaw, Tsilidis, Kostantinos, Ellingjord-Dale, Merete, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rohrmann, Sabine, and Kühn, Tilman
- Subjects
3. Good health - Abstract
Additional file 1: This file contains Table S1. The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations and the operationalization of the WCRF/AICR lifestyle score in the European Prospective Investigation into Cancer and Nutrition cohort; Table S2. The proportion of primary in situ breast cancer cases over the total primary breast cancer cases diagnosed in the European Prospective Investigation into Cancer and Nutrition cohort; Table S3. The association between the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and the risk for the most common morphological subtypes of BCIS (in the total study population and according to recruitment mode) in the European Prospective Investigation into Cancer and Nutrition cohort; Table S4. The associations between the individual components of the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and in situ breast cancer risk by menopausal status and menopausal hormone use assessed in the total study population.
49. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
- Author
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Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S, Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y N, Schmidt, Julie A, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H Susan J, Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J, Gunter, Marc J, and Ferrari, Pietro
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2. Zero hunger ,Prevention ,Diabetes ,Obesity ,Healthy Lifestyle ,Cardiovascular disease ,3. Good health ,Cancer ,Cancer And Cardiometabolic Multimorbidity - Abstract
BACKGROUND:Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. METHODS:In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. RESULTS:During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and women with healthy lifestyles. CONCLUSION:Pre-diagnostic healthy lifestyle behaviours were strongly inversely associated with the risk of cancer and cardiometabolic diseases, and with the prognosis of these diseases by reducing risk of multimorbidity.
50. MOESM1 of Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
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Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam, Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina, Menéndez, Virginia, Agudo, Antonio, Maria-Jose Sánchez, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio, Tong, Tammy, Schmidt, Julie, Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, H. Picavet, Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Mazda Jenab, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick, Gunter, Marc, and Ferrari, Pietro
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3. Good health - Abstract
Additional file 1: Figure S1. Provides the participant flow chart. Figure S2. Transitions to specific cancer and cardio-metabolic multimorbidity patterns. Figure S3. Results of subgroup analyses. Figure S4. CIFs for men and women of 55 years of age. Figure S5. Results of sensitivity analyses. Figure S6. Results for simplified HLI. Figure S7. CIFs for men and women of 55 years of age using the simplified HLI. and Figure S8. CIFs for men and women of 55 years of age for two groups of cancers. Table S1. Scoring of the healthy lifestyle index (HLI) and its simplified version.
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