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308 results on '"Santella, R M"'

11. Gene-specific promoter methylation is associated with micronuclei frequency in urothelial cells from individuals exposed to organic solvents and paints

Author

Hoyos-Giraldo, L S, primary, Escobar-Hoyos, L F, additional, Saavedra-Trujillo, D, additional, Reyes-Carvajal, I, additional, Muñoz, A, additional, Londoño-Velasco, E, additional, Tello, A, additional, Cajas-Salazar, N, additional, Ruíz, M, additional, Carvajal, S, additional, and Santella, R M, additional

Published
2015
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12. Subgroup report: head and neck cancer

Author

Spitz, M. R., Santella, R. M., Boffetta, P., Buffler, P., Buffler P, Rice JM, Baan R, Bird M, Boffetta P, Spitz, M.R., Santella, R.M., Boffetta, P., and Buffler, P.

Subjects
Subgroup report head neck cancer
Abstract

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Published
2004

13. Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer

Author

Crew, K. D., primary, Ho, K. A., additional, Brown, P., additional, Greenlee, H., additional, Bevers, T. B., additional, Arun, B., additional, Sneige, N., additional, Hudis, C., additional, McArthur, H. L., additional, Chang, J., additional, Rimawi, M., additional, Cornelison, T. L., additional, Cardelli, J., additional, Santella, R. M., additional, Wang, A., additional, Lippman, S. M., additional, and Hershman, D. L., additional

Published
2014
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14. Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2′- deoxyguanosine as a noninvasive biomarker of oxidative stress

Author

Evans, M D, Olinski, R, Loft, S, Cooke, M S, Rossner, Jr P, Sram, R, Henriksen, T, Poulsen, H E, Weimann, Allan, Barbieri, A, Sabatini, L, Violante, F, Kino, S, Ochi, T, Sakai, K, Takeuchi, M, Kasai, H, Meerman, J H N, Gackowski, D, Rozalski, R, Siomek, A, Halliwell, Barry, Jenner, Andrew M, Wang, H, Cerda, C, Saez, G, Haghdoost, S, Svoboda, P, Hu, C-W, Chao, M-R, Peng, K-Y, Shih, W-C, Wu, K-Y, Orhan, H, Istanbullu, N S, Mistry, V, Farmer, P B, Sandhu, J, Singh, R, Cortez, C, Su, Y, Santella, R M, Lambert, P, Smith, R, Evans, M D, Olinski, R, Loft, S, Cooke, M S, Rossner, Jr P, Sram, R, Henriksen, T, Poulsen, H E, Weimann, Allan, Barbieri, A, Sabatini, L, Violante, F, Kino, S, Ochi, T, Sakai, K, Takeuchi, M, Kasai, H, Meerman, J H N, Gackowski, D, Rozalski, R, Siomek, A, Halliwell, Barry, Jenner, Andrew M, Wang, H, Cerda, C, Saez, G, Haghdoost, S, Svoboda, P, Hu, C-W, Chao, M-R, Peng, K-Y, Shih, W-C, Wu, K-Y, Orhan, H, Istanbullu, N S, Mistry, V, Farmer, P B, Sandhu, J, Singh, R, Cortez, C, Su, Y, Santella, R M, Lambert, P, and Smith, R

Abstract

Of the DNA-derived biomarkers of oxidative stress, urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is the most frequently measured. However, there is significant discrepancy between chromatographic and immunoassay approaches, and intratechnique agreement among all available chromatography-based assays and ELISAs is yet to be established. This is a significant obstacle to their use in large molecular epidemiological studies. To evaluate the accuracy of intra/intertechnique and interlaboratory measurements, samples of phosphate buffered saline and urine, spiked with different concentrations of 8-oxoG, together with a series of urine samples from healthy individuals were distributed to ESCULA members. All laboratories received identical samples, including 2 negative controls that contained no added 8-oxodG. Data were returned from 17 laboratories, representing 20 methods, broadly classified as mass spectrometric (MS), electrochemical detection (EC), or enzyme-linked immunosorbant assay (ELISA). Overall, there was good within-technique agreement, with the majority of laboratories' results lying within 1 SD of their consensus mean. However, ELISA showed more within-technique variation than did the chromatographic techniques and, for the urine samples, reported higher values. Bland-Altman plots revealed good agreement between MS and EC methods but concentration-dependent deviation for ELISA. All methods ranked urine samples according to concentration similarly. Creatinine levels are routinely used as a correction factor for urine concentration, and therefore we also conducted an interlaboratory comparison of methods for urinary creatinine determination, in which the vast majority of values lay within 1 SD of the consensus value, irrespective of the analysis procedure. This study reveals greater consensus than previously expected, although concern remains over ELISA. © FASEB.

Published
2010

16. Immunohistochemical analysis of 4-aminobiphenyl-DNA adducts in oral mucosal cells of smokers and nonsmokers

Author

Romano, G., Mancini, R., Fedele, P., Curigliano, G., Flamini, G., Giovagnoli, M. R., Natalia MALARA, Boninsegna, A., Vecchione, A., Santella, R. M., and Cittadini, A.

Subjects
Adult, Male, DNA Adducts, Alcohol Drinking, Smoking, Mouth Mucosa, Aminobiphenyl Compounds, Humans, Female, Middle Aged, Immunohistochemistry
Abstract

The "biologically effective dose markers", DNA and protein adducts, are a direct index of carcinogen induced cell damage and an indirect one of genetic susceptibility. This study aimed to examine the dose-response relationship for 4-Aminobiphenyl-DNA adducts in oral cells of smokers and non smokers.An immunoperoxidase method with the monoclonal 3C8 antibody, which recognizes 4-Aminobiphenyl-DNA, has been used for detecting DNA damage in oral cells of 12 smokers and 12 non smokers.Higher staining for 4-Aminobiphenyl-DNA was detected in the cells of smokers (187 +/- 42) vs. non smokers (135 +/- 35) (p = 0.004), with a twofold range in relative staining for both groups, suggesting individual differences relevance in metabolizing carcinogens and/or repairing DNA damage.This non invasive method requiring small cell amounts is a tool for monitoring large groups of subjects at risk in primary prevention programs.

Published
1997

23. Evaluation of oxidative stress in a group of adolescents exposed to a high level of aflatoxin B1 a multi-center and multi-biomarker study

Author

Peng, T., primary, Li, L.-Q., additional, Peng, M.-H., additional, Liu, Z.-M., additional, Liu, T.-W., additional, Guo, Y., additional, Xiao, K.-Y., additional, Qin, Z., additional, Ye, X.-P., additional, Mo, X.-S., additional, Yan, L.-N., additional, Lee, B.-L., additional, Shen, H.-M., additional, Tamae, K., additional, Wang, L. W., additional, Wang, Q., additional, Khan, K. M., additional, Wang, K.-B., additional, Liang, R.-X., additional, Wei, Z.-L., additional, Kasai, H., additional, Ong, C. N., additional, and Santella, R. M., additional

Published
2007
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