17 results on '"Santarosa C"'
Search Results
2. History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics
- Author
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Sommaruga, S, additional, Chu, S., additional, Hwang, D., additional, Dearborn, J., additional, Sansing, L., additional, Cord, B., additional, Santarosa, C., additional, Samarth, G., additional, Petersen, N., additional, Gilmore, E., additional, Schindler, J., additional, Bijlenga, P., additional, Schaller, K., additional, Matouk, C., additional, Sheth, K, additional, and Falcone, G., additional
- Published
- 2018
- Full Text
- View/download PDF
3. High-Resolution Vessel Wall MRI in Ruptured Cranial Dural Arteriovenous Fistulas
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Sommaruga, S., additional, Cord, B., additional, Santarosa, C., additional, Yeung, J., additional, Johnson, M.H., additional, Hebert, R., additional, Bijlenga, P., additional, Schaller, K., additional, and Matouk, C., additional
- Published
- 2018
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4. Predictors of Vessel Wall Enhancement in Unruptured Intracranial Aneurysms
- Author
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Sommaruga, S., additional, Cord, B., additional, Santarosa, C., additional, Malhotra, A., additional, Jonhson, M., additional, Sheth, K., additional, Gunel, M., additional, Herbert, R., additional, Bijlenga, P., additional, Schaller, K., additional, Falcone, G., additional, and Matouk, C., additional
- Published
- 2018
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5. CLINICAL AND HORMONAL ASPECTS OF MALEHYPOGONADISM IN MYOTONIC DYSTROPHY
- Author
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Mastrogiacomo, I., Bonanni, G., Menegazzo, E., Santarosa, C., Pagani, E., Gennarelli, Massimo, and Angelini, C.
- Published
- 1996
6. Dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging for glioma grading: Preliminary comparison of vessel compartment and permeability parameters using hotspot and histogram analysis
- Author
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Antonella Iadanza, Lorenzo Bello, Corrado Santarosa, Antonella Castellano, Gian Marco Conte, Marcello Cadioli, Andrea Falini, Nicoletta Anzalone, Maria Rosa Terreni, Alberto Franzin, Massimo Caulo, Santarosa, C, Castellano, Antonella, Conte, Gm, Cadioli, M, Iadanza, A, Terreni, Mr, Franzin, A, Bello, L, Caulo, M, Falini, Andrea, and Anzalone, N.
- Subjects
Adult ,Male ,Contrast Media ,Pilot Projects ,Blood volume ,030218 nuclear medicine & medical imaging ,Capillary Permeability ,03 medical and health sciences ,0302 clinical medicine ,Region of interest ,Glioma ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Grading (tumors) ,Aged ,Blood Volume ,medicine.diagnostic_test ,Receiver operating characteristic ,Brain Neoplasms ,business.industry ,Reproducibility of Results ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,Image Enhancement ,medicine.disease ,Magnetic Resonance Imaging ,ROC Curve ,Dynamic contrast-enhanced MRI ,Female ,Neoplasm Grading ,business ,Nuclear medicine ,Perfusion ,030217 neurology & neurosurgery - Abstract
Introduction Dynamic susceptibility contrast (DSC)-MRI is a perfusion technique with high diagnostic accuracy for glioma grading, despite limitations due to inherent susceptibility effects. Dynamic contrast-enhanced (DCE)-MRI has been proposed as an alternative technique able to overcome the DSC-MRI shortcomings. This pilot study aimed at comparing the diagnostic accuracy of DSC and DCE-MRI for glioma grading by evaluating two estimates of blood volume, the DCE-derived plasma volume (Vp) and the DSC-derived relative cerebral blood volume (rCBV), and a measure of vessel permeability, the DCE-derived volume transfer constant K trans . Methods Twenty-six newly diagnosed glioma patients underwent 3T-MR DCE and DSC imaging. Parametric maps of CBV, Vp and K trans were calculated and the region of highest value ( hotspot ) was measured on each map. Histograms of rCBV, Vp and K trans values were calculated for the tumor volume. Statistical differences according to WHO grade were assessed. The diagnostic accuracy for tumor grading of the two techniques was determined by ROC analysis. Results rCBV, Vp and K trans measures differed significantly between high and low-grade gliomas. Hotspot analysis showed the highest correlation with grading. K trans hotspots co-localized with Vp hotspots only in 56% of enhancing gliomas. For differentiating high from low-grade gliomas the AUC was 0.987 for rCBV max , and 1.000 for Vp max and K trans max . Combination of DCE-derived Vp and K trans parameters improved the diagnostic performance of the histogram method. Conclusion This initial experience of DCE-derived Vp evaluation shows that this parameter is as accurate as the well-established DSC-derived rCBV for glioma grading. DCE-derived K trans is equally useful for grading, providing different informations with respect to Vp.
- Published
- 2016
7. Patient Risk Factors Associated With 30- and 90-Day Readmission After Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients: A Nationwide Readmission Study.
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Koo AB, Elsamadicy AA, Lin IH, David WB, Reeves BC, Santarosa C, Cord B, Malhotra A, Kahle KT, and Matouk CC
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- Aged, Aged, 80 and over, Cohort Studies, Female, Follow-Up Studies, Humans, Hydrocephalus, Normal Pressure diagnosis, Male, Postoperative Complications diagnosis, Retrospective Studies, Risk Factors, Time Factors, United States epidemiology, Ventriculoperitoneal Shunt adverse effects, Hydrocephalus, Normal Pressure epidemiology, Hydrocephalus, Normal Pressure surgery, Patient Readmission trends, Postoperative Complications epidemiology, Ventriculoperitoneal Shunt trends
- Abstract
Objective: For idiopathic normal pressure hydrocephalus (iNPH), risk stratifying patients and identifying those who are likely to fare well after ventriculoperitoneal shunt (VP) surgery may help improve quality of care and reduce unplanned readmissions. The aim of this study was to investigate the drivers of 30- and 90-day readmissions after VP shunt surgery for iNPH in elderly patients., Methods: The Nationwide Readmission Database, years 2013 to 2015, was queried. Elderly patients (≥65 years old) undergoing VP shunt surgery were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification coding system. Unique patient linkage numbers were used to follow patients and identify 30- and 31- to 90-day readmission rates. Patients were grouped by no readmission (Non-R), readmission within 30 days (30-R), and readmission within 31 to 90 days (90-R)., Results: We identified 7199 elderly patients undergoing VP shunt surgery for iNPH. A total of 1413 (19.6%) patients were readmitted (30-R: n = 812 [11.3%] vs. 90-R: n = 601 [8.3%] vs. Non-R: n = 5786). The most prevalent 30- and 90-day complications seen among the readmitted cohort were mechanical complication of nervous system device implant (30-R: 16.1%, 90-R: 12.4%), extracranial postoperative infection (30-R: 10.4%, 90-R: 7.0%), and subdural hemorrhage (30-R: 6.0%, 90-R: 16.4%). On multivariate regression analysis, age, diabetes, and renal failure were independently associated with 30-day readmission; female sex, and 26th to 50th household income percentile were independently associated with reduced likelihood of 90-day readmission. Having any complication during the index admission independently associated with both 30- and 90-day readmission., Conclusions: In this study, we identify the most common drivers for readmission for elderly patients with iNPH undergoing VP shunt surgery., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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8. Vessel wall MRI in ruptured cranial dural arteriovenous fistulas.
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Cord BJ, Renedo D, Santarosa C, Sujijantarat N, Antonios J, Kim JA, Falcone GJ, Sheth KN, Malhotra A, and Matouk CC
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- Humans, Magnetic Resonance Imaging, Central Nervous System Vascular Malformations diagnostic imaging, Intracranial Aneurysm, Subarachnoid Hemorrhage diagnostic imaging
- Abstract
Intracranial high-resolution vessel wall MRI (VW-MRI) is an imaging paradigm that is useful in site-of-rupture identification in patients presenting with spontaneous subarachnoid hemorrhage and multiple intracranial aneurysms. Only a handful of case reports describe its potential utility in the evaluation of more complex brain vascular malformations. We report for the first time three patients with ruptured cranial dural arteriovenous fistulas (dAVFs) that were evaluated with high-resolution VW-MRI. The presumed site-of-rupture was identified based on contiguity of a venous ectasia with adjacent blood products and thick, concentric wall enhancement. This preliminary experience suggests a role for high-resolution VW-MRI in the evaluation of ruptured cranial dAVFs, in particular, site-of-rupture identification. It also supports an emerging hypothesis that all spontaneously ruptured, macrovascular lesions demonstrate avid vessel wall enhancement.
- Published
- 2021
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9. Predictors of Extended Length of Stay Following Treatment of Unruptured Adult Cerebral Aneurysms: A Study of The National Inpatient Sample.
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Koo AB, Elsamadicy AA, Lin IH, David WB, Sujijantarat N, Santarosa C, Cord BJ, Zetchi A, Hebert R, Bahrassa F, Malhotra A, and Matouk CC
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- Aged, Comorbidity, Databases, Factual, Female, Hospital Costs, Humans, Inpatients, Intracranial Aneurysm diagnostic imaging, Intracranial Aneurysm economics, Male, Middle Aged, Patient Admission, Postoperative Complications therapy, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, United States, Endovascular Procedures adverse effects, Endovascular Procedures economics, Intracranial Aneurysm surgery, Length of Stay economics, Microsurgery adverse effects, Microsurgery economics, Outcome and Process Assessment, Health Care economics, Quality Indicators, Health Care economics
- Abstract
Background: In an unprecedented era of soaring healthcare costs, payers and providers alike have started to place increased importance on measuring the quality of surgical procedures as a surrogate for operative success. One metric used is the length of hospital stay (LOS) during index admission. For the treatment of unruptured cerebral aneurysms, the determinants of extended length of stay are relatively unknown. The aim of this study was to identify the patient- and hospital-level factors associated with extended LOS following treatment for unruptured cerebral aneurysms., Methods: The National Inpatient Sample years 2010 - 2014 was queried. Adults (≥18 years) with unruptured aneurysms undergoing either clipping or coiling were selected using the International Classification of Diseases, Ninth Revision, Clinical Modification coding system. Extended LOS was defined as greater than 75
th percentile for the entire cohort (>5 days). Weighted patient demographics, comorbidities, complications, LOS, disposition and total cost were recorded. Multivariate logistic regression was used to determine the odds ratio for risk-adjusted extended LOS. The primary outcome was the degree which patient comorbidities or postoperative complications correlated with extended LOS., Results: A total of 46,880 patients were identified for which 9,774 (20.8%) patients had extended LOS (Normal LOS: 37,106; Extended LOS: 9,774). Patients in the extended LOS cohort presented with a greater number of comorbidities compared to the normal LOS cohort. A greater proportion of the normal LOS cohort was coiled (Normal LOS: 63.0% vs. Extended LOS: 33.5%, P<0.001), while more patients in the extended LOS cohort were clipped (Normal LOS: 37.0% vs. Extended LOS: 66.5%, P<0.001). The overall complication rate was higher in the extended LOS cohort (Normal LOS: 7.3% vs. Extended LOS: 43.8%, P<0.001). On average, the extended LOS cohort incurred a total cost nearly twice as large (Normal LOS: $26,050 ± 13,430 vs. Extended LOS: $52,195 ± 37,252, P<0.001) and had more patients encounter non-routine discharges (Normal LOS: 8.5% vs. Extended LOS: 52.5%, P<0.001) compared to the normal LOS cohort. On weighted multivariate logistic regression, multiple patient-specific factors were associated with extended LOS. These included demographics, preadmission comorbidities, choice of procedure, and inpatient complications. The odds ratio for extended LOS was 5.14 (95% CI, 4.30 - 6.14) for patients with 1 complication and 19.58 (95% CI, 15.75 - 24.34) for patients with > 1 complication., Conclusions: Our study demonstrates that extended LOS after treatment of unruptured aneurysms is influenced by a number of patient-level factors including demographics, preadmission comorbidities, type of aneurysm treatment (open surgical versus endovascular), and, importantly, inpatient complications. A better understanding of these independent predictors of prolonged length of hospital stay may help to improve patient outcomes and decrease overall healthcare costs., Competing Interests: Declaration of Competing Interest None., (Copyright © 2020 Elsevier Inc. All rights reserved.)- Published
- 2020
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10. Thirty- and 90-Day Readmissions After Treatment of Traumatic Subdural Hematoma: National Trend Analysis.
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Koo AB, Elsamadicy AA, David WB, Zogg CK, Santarosa C, Sujijantarat N, Robert SM, Kundishora AJ, Cord BJ, Hebert R, Bahrassa F, Malhotra A, and Matouk CC
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, United States epidemiology, Hematoma, Subdural surgery, Patient Readmission trends, Postoperative Complications epidemiology, Postoperative Complications etiology
- Abstract
Objective: Subdural hematoma (SDH), a form of traumatic brain injury, is a common disease that requires extensive patient management and resource utilization; however, there remains a paucity of national studies examining the likelihood of readmission in this patient population. The aim of this study is to investigate differences in 30- and 90-day readmissions for treatment of traumatic SDH using a nationwide readmission database., Methods: The Nationwide Readmission Database years 2013-2015 were queried. Patients with a diagnosis of traumatic SDH and a primary procedure code for incision of cerebral meninges for drainage were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification coding system. Patients were grouped by no readmission (Non-R), readmission within 30 days (30-R), and readmission within 31-90 days (90-R)., Results: We identified a total of 14,355 patients, with 3106 (21.6%) patients encountering a readmission (30-R: n = 2193 [15.3%]; 90-R: n = 913 [6.3%]; Non-R: n = 11,249). The most prevalent 30- and 90-day diagnoses seen among the readmitted cohorts were postoperative infection (30-R: 10.5%, 90-R: 13.0%) and epilepsy (30-R: 3.7%, 90-R: 1.1%). On multivariate logistic regression analysis, Medicare, Medicaid, hypertension, diabetes, renal failure, congestive heart failure, and coagulopathy were independently associated with 30-day readmission; Medicare and rheumatoid arthritis/collagen vascular disease were independently associated with 90-day readmission., Conclusions: In this study, we determine the relationship between readmission rates and complications associated with surgical intervention for traumatic subdural hematoma., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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11. Vessel wall magnetic resonance imaging in intracranial aneurysms: Principles and emerging clinical applications.
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Santarosa C, Cord B, Koo A, Bhogal P, Malhotra A, Payabvash S, Minja FJ, and Matouk CC
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- Humans, Intracranial Aneurysm surgery, Intracranial Aneurysm therapy, Magnetic Resonance Angiography methods, Blood Vessels diagnostic imaging, Intracranial Aneurysm diagnostic imaging, Magnetic Resonance Imaging methods
- Abstract
Intracranial high-resolution vessel wall magnetic resonance imaging is an imaging paradigm that complements conventional imaging modalities used in the evaluation of neurovascular pathology. This review focuses on the emerging utility of vessel wall magnetic resonance imaging in the characterization of intracranial aneurysms. We first discuss the technical principles of vessel wall magnetic resonance imaging highlighting methods to determine aneurysm wall enhancement and how to avoid common interpretive pitfalls. We then review its clinical application in the characterization of ruptured and unruptured intracranial aneurysms, in particular, the emergence of aneurysm wall enhancement as a biomarker of aneurysm instability. We offer our perspective from a high-volume neurovascular center where vessel wall magnetic resonance imaging is in routine clinical use.
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- 2020
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12. How Flow Reduction Influences the Intracranial Aneurysm Occlusion: A Prospective 4D Phase-Contrast MRI Study.
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Brina O, Bouillot P, Reymond P, Luthman AS, Santarosa C, Fahrat M, Lovblad KO, Machi P, Delattre BMA, Pereira VM, and Vargas MI
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- Adult, Endovascular Procedures methods, Female, Hemodynamics physiology, Humans, Male, Middle Aged, Prospective Studies, Stents, Intracranial Aneurysm diagnostic imaging, Intracranial Aneurysm physiopathology, Intracranial Aneurysm surgery, Magnetic Resonance Imaging methods, Neuroimaging methods, Neurosurgical Procedures methods
- Abstract
Background and Purpose: Flow-diverter stents are widely used for the treatment of wide-neck intracranial aneurysms. Various parameters may influence intracranial aneurysm thrombosis, including the flow reduction induced by flow-diverter stent implantation, which is assumed to play a leading role. However, its actual impact remains unclear due to the lack of detailed intra-aneurysmal flow measurements. This study aimed to clarify this relationship by quantitatively measuring the intra-aneurysmal flow using 4D phase-contrast MR imaging., Materials and Methods: We acquired prospective pre- and post-stent implantation 4D phase-contrast MR imaging data of a consecutive series of 23 patients treated with flow-diverter stents. Velocity field data were combined with the intraprocedural 3D angiogram vessel geometries for precise intracranial aneurysm extraction and partial volume correction. Intra-aneurysmal hemodynamic modifications were compared with occlusion outcomes at 6 and 12 months., Results: The averaged velocities at systole were lower after flow-diverter stent implantation for all patients and ranged from 21.7 ± 7.1 cm/s before to 7.2 ± 2.9 cm/s after stent placement. The velocity reduction was more important for the group of patients with aneurysm thrombosis at 6 months (68.8%) and decreased gradually from 66.2% to 55% for 12-month thrombosis and no thrombosis, respectively ( P = .08)., Conclusions: We propose an innovative approach to measure intracranial flow changes after flow-diverter stent implantation. We identified a trend between flow reduction and thrombosis outcome that brings a new insight into current understanding of the flow-diversion treatment response., (© 2019 by American Journal of Neuroradiology.)
- Published
- 2019
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13. Carotidynia: A Rare Diagnosis for Unilateral Neck Pain Revealed by Cross-Sectional Imaging.
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Santarosa C, Stefanelli S, Sztajzel R, Mundada P, and Becker M
- Abstract
Idiopathic carotidynia (IC) is a rare and poorly understood syndrome consisting of unilateral neck pain, tenderness, and increased pulsations over the affected carotid bifurcation. A growing body of evidence supports the hypothesis that IC is a distinct clinicopathologic entity with characteristic imaging features. We report the case of a 34-year-old Caucasian male presenting with intense unilateral neck pain in the emergency setting. Computed tomography and ultrasonography revealed fusiform eccentric thickening of the ipsilateral carotid bifurcation without vessel narrowing. Contrast-enhanced magnetic resonance imaging depicted major perivascular enhancement without evidence of dissection. Further imaging and laboratory work-up excluded vasculitis. The diagnosis of IC was made. The patient was treated with nonsteroidal anti-inflammatory drugs and symptoms and imaging findings disappeared within a few weeks. Cross-sectional imaging allows not only ruling out IC mimickers but also making the correct diagnosis of this rare condition, in particular, as the clinical presentation of IC is often nonspecific.
- Published
- 2017
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14. Longitudinal MRI quantification of muscle degeneration in Duchenne muscular dystrophy.
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Godi C, Ambrosi A, Nicastro F, Previtali SC, Santarosa C, Napolitano S, Iadanza A, Scarlato M, Natali Sora MG, Tettamanti A, Gerevini S, Cicalese MP, Sitzia C, Venturini M, Falini A, Gatti R, Ciceri F, Cossu G, Torrente Y, and Politi LS
- Abstract
Objective: The aim of this study was to evaluate the usefulness of magnetic resonance imaging (MRI) in detecting the progression of Duchenne muscular dystrophy (DMD) by quantification of fat infiltration (FI) and muscle volume index (MVI, a residual-to-total muscle volume ratio)., Methods: Twenty-six patients (baseline age: 5-12 years) with genetically proven DMD were longitudinally analyzed with lower limb 3T MRI, force measurements, and functional tests (Gowers, 10-m time, North Star Ambulatory Assessment, 6-min walking test). Five age-matched controls were also examined, with a total of 85 MRI studies. Semiquantitative (scores) and quantitative MRI (qMRI) analyses (signal intensity ratio - SIR, lower limb MVI, and individual muscle MVI) were carried out. Permutation and regression analyses according to both age and functional test-outcomes were calculated. Age-related quantitative reference curves of SIRs and MVIs were generated., Results: FI was present on glutei and adductor magnus in all patients since the age of 5, with a proximal-to-distal progression and selective sparing of sartorius and gracilis. Patients' qMRI measures were significantly different from controls' and among age classes. qMRI were more sensitive than force measurements and functional tests in assessing disease progression, allowing quantification also after loss of ambulation. Age-related curves with percentile values were calculated for SIRs and MVIs, to provide a reference background for future experimental therapy trials. SIRs and MVIs significantly correlated with all clinical measures, and could reliably predict functional outcomes and loss of ambulation., Interpretations: qMRI-based indexes are sensitive measures that can track the progression of DMD and represent a valuable tool for follow-up and clinical studies.
- Published
- 2016
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15. Dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging for glioma grading: Preliminary comparison of vessel compartment and permeability parameters using hotspot and histogram analysis.
- Author
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Santarosa C, Castellano A, Conte GM, Cadioli M, Iadanza A, Terreni MR, Franzin A, Bello L, Caulo M, Falini A, and Anzalone N
- Subjects
- Adult, Aged, Blood Volume physiology, Brain Neoplasms physiopathology, Capillary Permeability physiology, Female, Glioma physiopathology, Humans, Male, Middle Aged, Neoplasm Grading, Pilot Projects, ROC Curve, Reproducibility of Results, Brain Neoplasms diagnostic imaging, Brain Neoplasms pathology, Contrast Media, Glioma diagnostic imaging, Glioma pathology, Image Enhancement methods, Magnetic Resonance Imaging methods
- Abstract
Introduction: Dynamic susceptibility contrast (DSC)-MRI is a perfusion technique with high diagnostic accuracy for glioma grading, despite limitations due to inherent susceptibility effects. Dynamic contrast-enhanced (DCE)-MRI has been proposed as an alternative technique able to overcome the DSC-MRI shortcomings. This pilot study aimed at comparing the diagnostic accuracy of DSC and DCE-MRI for glioma grading by evaluating two estimates of blood volume, the DCE-derived plasma volume (Vp) and the DSC-derived relative cerebral blood volume (rCBV), and a measure of vessel permeability, the DCE-derived volume transfer constant K(trans)., Methods: Twenty-six newly diagnosed glioma patients underwent 3T-MR DCE and DSC imaging. Parametric maps of CBV, Vp and K(trans) were calculated and the region of highest value (hotspot) was measured on each map. Histograms of rCBV, Vp and K(trans) values were calculated for the tumor volume. Statistical differences according to WHO grade were assessed. The diagnostic accuracy for tumor grading of the two techniques was determined by ROC analysis., Results: rCBV, Vp and K(trans) measures differed significantly between high and low-grade gliomas. Hotspot analysis showed the highest correlation with grading. K(trans) hotspots co-localized with Vp hotspots only in 56% of enhancing gliomas. For differentiating high from low-grade gliomas the AUC was 0.987 for rCBVmax, and 1.000 for Vpmax and K(trans)max. Combination of DCE-derived Vp and K(trans) parameters improved the diagnostic performance of the histogram method., Conclusion: This initial experience of DCE-derived Vp evaluation shows that this parameter is as accurate as the well-established DSC-derived rCBV for glioma grading. DCE-derived K(trans) is equally useful for grading, providing different informations with respect to Vp., (Copyright © 2016. Published by Elsevier Ireland Ltd.)
- Published
- 2016
- Full Text
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16. [EPIDEMIOLOGICAL AND CLINICAL STUDY OF LEPTOSPIROSIS AMONG PRISONERS IN S AO PAULO].
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MEIRA DA and SANTAROSA CA
- Subjects
- Brazil, Epidemiology, Leptospirosis, Prisoners, Prisons, Serologic Tests
- Published
- 1964
17. APPLICATION OF A MICROTECHNIQUE TO THE AGGLUTINATION TEST FOR LEPTOSPIRAL ANTIBODIES.
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GALTON MM, SULZER CR, SANTAROSA CA, and FIELDS MJ
- Subjects
- Animals, Humans, Agglutination Tests, Antibodies, Antibodies, Bacterial, Antigens, Bacterial, Clinical Laboratory Techniques, Hemagglutination, Hemagglutination Tests, Laboratories, Leptospira, Leptospirosis, Reproducibility of Results
- Abstract
A microtechnique has been developed and adapted successfully to the microscopic agglutination test with live antigens for detection of leptospiral antibodies. Simultaneous titrations were performed by the conventional microscopic agglutination test and the microtechnique. When the microtechnique was used to screen 50 unknown leptospiral strains with a battery of hyperimmune sera, 98% agreement was obtained with the conventional procedure. Comparative data on 635 tests on these 50 cultures established the reliability of the microtechnique. Results with the two tests on 46 human sera revealed 93% agreement in the detection of leptospiral antibodies. The validity and reliability of the microtechnique obtained in these comparative studies suggests that it can be used as a valuable screening procedure for the microscopic agglutination test for preliminary cross agglutination studies on unknown strains and for the detection of leptospiral antibodies in human and animal sera.
- Published
- 1965
- Full Text
- View/download PDF
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