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1. Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

Author

Bogani, Giorgio, Donato, Violante Di, Scambia, Giovanni, Ghezzi, Fabio, Casarin, Jvan, Landoni, Fabio, Di Martino, Giampaolo, Grassi, Tommaso, Perrone, Anna Myriam, De Iaco, Pierandrea, Multinu, Francesco, Berretta, Roberto, Capozzi, Vito A., Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Scutiero, Gennaro, Sopracordevole, Francesco, Giorda, Giorgio, Fichera, Mariasole, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Giampaolino, Pierluigi, Bifulco, Giuseppe, Morelli, Michele, Dio, Michele Di, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Cianci, Stefano, Chiantera, Vito, Sozzi, Giulio, Ercoli, Alfredo, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G., Ettore, Giuseppe, Puppo, Andrea, Olearo, Elena, Leone Roberti Maggiore, Umberto, Artuso, Valeria, Palaia, Innocenza, Perniola, Giorgia, Tripodi, Rossana, D'Augè, Tullio Golia, Cuccu, Ilaria, Fischetti, Margherita, Santangelo, Giusi, Casorelli, Assunta, Giannini, Andrea, D’Oria, Ottavia, Vizzielli, Giuseppe, Restaino, Stefano, Bergamini, Alice, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassini, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thommaset, Raphaël, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Falcone, Francesca, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Capobianco, Giampiero, Ciavattini, Andrea, Mereu, Liliana, Scollo, Paolo, Sorbi, Flavia, Fambrini, Massimiliano, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Damiani, Gianluca Raffaello, Consonni, Roberto, Di Lorenzo, Nadia, Lippolis, Antonio, Tinelli, Raffaele, Aguzzoli, Lorenzo, Mandato, Vincenzo D., Palomba, Stefano, Tripodi, Marcello, Calandra, Davide, Pellegrini, Franco, Zullo, Fulvio, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Vizza, Enrico, Muzii, Ludovico, Panici, Pierluigi Benedetti, and Raspagliesi, Francesco

Published
2022
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4. Safety and efficacy of a class II medical device based on highly purified and standardized plant extracts in the management of post-menopausal patients with vulvar and vaginal atrophy: a single-center prospective observational study.

Author

GALLI, Valerio, GOLIA D'AUGÈ, Tullio, DI PIERRO, Francesco, CAZZANIGA, Massimiliano, GUASTI, Luigina, ZERBINATI, Nicola, BERTUCCIOLI, Alexander, KHAN, Amjad, D'OVIDIO, Giulia, IACULLI, Francesco, TIBALDI, Valentina, SANTANGELO, Giusi, FISCHETTI, Margherita, CASORELLI, Assunta F., DI DONATO, Violante, GIANNINI, Andrea, MUSELLA, Angela, GIANCOTTI, Antonella, and MONTI, Marco

Subjects
MEDICAL personnel, SENTINEL lymph node biopsy, BODY mass index, CARBON dioxide lasers, HORMONE therapy, PREMATURE menopause, VULVAR cancer
Published
2024
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5. Spotlight on compounded bioidentical hormones

Author

Santangelo, Giusi, primary, Lagana, Antonio Simone, additional, Giannini, Andrea, additional, Murina, Filippo, additional, Di Dio, Camilla, additional, Ruggiero, Gianfilippo, additional, Di Donato, Violante, additional, Perniola, Giorgia, additional, Fischetti, Margherita, additional, Casorelli, Assunta, additional, Clemente, Francesco Francesco, additional, Minnetti, Marianna, additional, Lombardo, Francesco, additional, Panici, Pierluigi Benedetti, additional, Muzii, Ludovico, additional, and Bogani, Giorgio, additional

Published
2023
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7. Spotlight on Compounded Bioidentical Hormones.

Author

Santangelo, Giusi, Lagana, Antonio Simone, Giannini, Andrea, Murina, Filippo, Di Dio, Camilla, Ruggiero, Gianfilippo, Di Donato, Violante, Perniola, Giorgia, Fischetti, Margherita, Casorelli, Assunta, Clemente, Francesco, Minnetti, Marianna, Lombardo, Francesco, Benedetti Panici, Pierluigi, Muzii, Ludovico, and Bogani, Giorgio

Subjects
*HORMONE therapy, *SPECIALTY pharmacies, *STEROID hormones, *HORMONES, *WOMEN'S health
Abstract

Background: The role of hormonal replacement therapy in menopause is under debate. The premature closure of the Women's Health Initiative (WHI) study in 2002 is still a source of concern among treating physicians. Objectives: The interest in alternatives to conventional hormone therapy has significantly increased. The adoption of personalized steroid hormone galenic preparations, formulated by compounding pharmacies, has recently spread. Methods: In June 2023, an extensive literature search was conducted by different authors to identify relevant studies in various databases (MEDLINE, Embase, PubMed, and Cochrane). The studies that met the inclusion and exclusion criteria were further analyzed, and relevant data were extracted and analyzed for each paper. Any discrepancies between the investigators were resolved through a consensus approach. Outcomes: The primary outcomes observed included the clinical utility of CBHT. This study reviewed the current evidence on the utility of compounded bioidentical hormones, concluding that improving knowledge and awareness of bioidentical hormones is necessary to consider their use in clinical practice. Conclusion and Outlook: These formulations might provide effective options to best tailor therapies to each patient. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Vulvodynia: A practical guide in treatment strategies

Author

Santangelo, Giusi, primary, Ruggiero, Gianfilippo, additional, Murina, Filippo, additional, Di Donato, Violante, additional, Perniola, Giorgia, additional, Palaia, Innocenza, additional, Fischetti, Margherita, additional, Casorelli, Assunta, additional, Giannini, Andrea, additional, Di Dio, Camilla, additional, Muzii, Ludovico, additional, Benedetti Panici, Pierluigi, additional, and Bogani, Giorgio, additional

Published
2023
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10. Assessing the role of low volume disease in endometrial cancer

Author

Bogani, Giorgio, primary, Palaia, Innocenza, additional, Perniola, Giorgia, additional, Fracassi, Alice, additional, Cuccu, Ilaria, additional, Golia D'Auge, Tullio, additional, Casorelli, Assunta, additional, Santangelo, Giusi, additional, Fischetti, Margherita, additional, Muzii, Ludovico, additional, Benedetti Panici, Pierluigi, additional, and Di Donato, Violante, additional

Published
2022
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11. Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Author

Bogani, Giorgio, Lalli, Luca, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Palaia, Innocenza, Perniola, Giorgia, Fischetti, Margherita, Santangelo, Giusi, Fracassi, Alice, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Cianci, Stefano, Bosio, Sara, Ruisi, Simona, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa Pasqualina, Zannoni, Gian Franco, Ferrandina, Maria Gabriella, Petrillo, Marco, Capobianco, Giampiero, Dessiole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Muschiato, Barbara, Palomba, Stefano, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Angioli, Roberto, Benedetti Panici, Pierluigi, Muzii, Ludovico, Scambia, Giovanni, Raspagliesi, Francesco, Di Donato, Violante, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Bogani, Giorgio, Lalli, Luca, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Palaia, Innocenza, Perniola, Giorgia, Fischetti, Margherita, Santangelo, Giusi, Fracassi, Alice, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Cianci, Stefano, Bosio, Sara, Ruisi, Simona, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa Pasqualina, Zannoni, Gian Franco, Ferrandina, Maria Gabriella, Petrillo, Marco, Capobianco, Giampiero, Dessiole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Muschiato, Barbara, Palomba, Stefano, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Angioli, Roberto, Benedetti Panici, Pierluigi, Muzii, Ludovico, Scambia, Giovanni, Raspagliesi, Francesco, Di Donato, Violante, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), and Scambia, Giovanni (ORCID:0000-0003-2758-1063)

Abstract

Background: Cervical dysplasia persistence/recurrence has a great impact on women's health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. Methods: This is a retrospective multi-institutional study based on charts of consecutive patients undergoing conization between 1 January 2010 and 31 December 2014. A nomogram assessing the importance of different variables was built. A cohort of patients treated between 1 January 2015 and 30 June 2016 was used to validate the nomogram. Results: A total of 2966 patients undergoing primary conization were analyzed. The median (range) patient age was 40 (18-89) years. At 5-year of follow-up, 6% of patients (175/2966) had developed a persistent/recurrent cervical dysplasia. Median (range) recurrence-free survival was 18 (5-52) months. Diagnosis of CIN3, presence of HR-HPV types, positive endocervical margins, HPV persistence, and the omission of HPV vaccination after conization increased significantly and independently of the risk of developing cervical dysplasia persistence/recurrence. A nomogram weighting the impact of all variables was built with a C-Index of 0.809. A dataset of 549 patients was used to validate the nomogram, with a C-index of 0.809. Conclusions: The present nomogram represents a useful tool for counseling women about their risk of persistence/recurrence after primary conization. HPV vaccination after conization is associated with a reduced risk of CIN2+.

Published
2022

12. Intravoxel Incoherent Motion (IVIM) MR Quantification in Locally Advanced Cervical Cancer (LACC): Preliminary Study on Assessment of Tumor Aggressiveness and Response to Neoadjuvant Chemotherapy

Author

Dolciami, Miriam, primary, Capuani, Silvia, additional, Celli, Veronica, additional, Maiuro, Alessandra, additional, Pernazza, Angelina, additional, Palaia, Innocenza, additional, Di Donato, Violante, additional, Santangelo, Giusi, additional, Rizzo, Stefania Maria Rita, additional, Ricci, Paolo, additional, Della Rocca, Carlo, additional, Catalano, Carlo, additional, and Manganaro, Lucia, additional

Published
2022
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13. Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Author

Bogani, Giorgio, primary, Lalli, Luca, additional, Sopracordevole, Francesco, additional, Ciavattini, Andrea, additional, Ghelardi, Alessandro, additional, Simoncini, Tommaso, additional, Plotti, Francesco, additional, Casarin, Jvan, additional, Serati, Maurizio, additional, Pinelli, Ciro, additional, Bergamini, Alice, additional, Gardella, Barbara, additional, Dell’Acqua, Andrea, additional, Monti, Ermelinda, additional, Vercellini, Paolo, additional, Palaia, Innocenza, additional, Perniola, Giorgia, additional, Fischetti, Margherita, additional, Santangelo, Giusi, additional, Fracassi, Alice, additional, D’Ippolito, Giovanni, additional, Aguzzoli, Lorenzo, additional, Mandato, Vincenzo Dario, additional, Giannella, Luca, additional, Scaffa, Cono, additional, Falcone, Francesca, additional, Borghi, Chiara, additional, Malzoni, Mario, additional, Giannini, Andrea, additional, Salerno, Maria Giovanna, additional, Liberale, Viola, additional, Contino, Biagio, additional, Donfrancesco, Cristina, additional, Desiato, Michele, additional, Perrone, Anna Myriam, additional, Dondi, Giulia, additional, De Iaco, Pierandrea, additional, Ferrero, Simone, additional, Sarpietro, Giuseppe, additional, Matarazzo, Maria G., additional, Cianci, Antonio, additional, Cianci, Stefano, additional, Bosio, Sara, additional, Ruisi, Simona, additional, Mosca, Lavinia, additional, Tinelli, Raffaele, additional, De Vincenzo, Rosa, additional, Zannoni, Gian Franco, additional, Ferrandina, Gabriella, additional, Petrillo, Marco, additional, Capobianco, Giampiero, additional, Dessiole, Salvatore, additional, Carlea, Annunziata, additional, Zullo, Fulvio, additional, Muschiato, Barbara, additional, Palomba, Stefano, additional, Greggi, Stefano, additional, Spinillo, Arsenio, additional, Ghezzi, Fabio, additional, Colacurci, Nicola, additional, Angioli, Roberto, additional, Benedetti Panici, Pierluigi, additional, Muzii, Ludovico, additional, Scambia, Giovanni, additional, Raspagliesi, Francesco, additional, and Di Donato, Violante, additional

Published
2022
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17. The contribution of the 1H-MRS lipid signal to cervical cancer prognosis: a preliminary study.

Author

Dolciami, Miriam, Canese, Rossella, Testa, Claudia, Pernazza, Angelina, Santangelo, Giusi, Palaia, Innocenza, Rocca, Carlo Della, Catalano, Carlo, and Manganaro, Lucia

Subjects
CERVICAL cancer, CANCER prognosis, PROTON magnetic resonance spectroscopy, MAGNETIC resonance imaging, LIPIDS
Abstract

Background: The aim of this study was to investigate the role of the lipid peak derived from 1H magnetic resonance (MR) spectroscopy in assessing cervical cancer prognosis, particularly in assessing response to neoadjuvant chemotherapy (NACT) of locally advanced cervical cancer (LACC). Methods: We enrolled 17 patients with histologically proven cervical cancer who underwent 3-T MR imaging at baseline. In addition to conventional imaging sequences for pelvic assessment, the protocol included a single-voxel point-resolved spectroscopy (PRESS) sequence, with repetition time of 1,500 ms and echo times of 28 and 144 ms. Spectra were analysed using the LCModel fitting routine, thus extracting multiple metabolites, including lipids (Lip) and total choline (tCho). Patients with LACC were treated with NACT and reassessed by MRI at term. Based on tumour volume reduction, patients were classified as good responder (GR; tumour volume reduction > 50%) and poor responder or nonresponder (PR-or-NR; tumour volume reduction ≤ 50%). Results: Of 17 patients, 11 were LACC. Of these 11, only 6 had both completed NACT and had good-quality 1H-MR spectra; 3 GR and 3 PR-or-NR. A significant difference in lipid values was observed in the two groups of patients, particularly with higher Lip values and higher Lip/tCho ratio in PR-NR patients (p =0.040). A significant difference was also observed in choline distribution (tCho), with higher values in GR patients (p = 0.040). Conclusions: Assessment of lipid peak at 1H-MR spectroscopy could be an additional quantitative parameter in predicting the response to NACT in patients with LACC. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Urinary incontinence in women: state of the art and medical treatment

Author

MONTI, Marco, primary, FISCHETTI, Margherita, additional, SANTANGELO, Giusi, additional, GALLI, Valerio, additional, CLEMENTE, Francesco, additional, GIANNINI, Andrea, additional, TIBALDI, Valentina, additional, DI PINTO, Anna, additional, PECORINI, Francesco, additional, PERNIOLA, Giorgia, additional, DI DONATO, Violante, additional, and BENEDETTI PANICI, Pierluigi, additional

Published
2021
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19. Update on surgical treatment of female stress urinary incontinence

Author

MONTI, Marco, primary, FISCHETTI, Margherita, additional, DI PINTO, Anna, additional, SANTANGELO, Giusi, additional, GIANNINI, Andrea, additional, D’ORIA, Ottavia, additional, GOLIA D’AUGÈ, Tullio, additional, CARBONE, Fabiana, additional, PERNIOLA, Giorgia, additional, DI DONATO, Violante, additional, PALAIA, Innocenza, additional, MUZII, Ludovico, additional, and BENEDETTI PANICI, Pierluigi, additional

Published
2021
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20. Relationship between cervical excisional treatment for cervical intraepithelial neoplasia and obstetrical outcome

Author

MONTI, Marco, primary, D’ANIELLO, Debora, additional, SCOPELLITI, Annalisa, additional, TIBALDI, Valentina, additional, SANTANGELO, Giusi, additional, COLAGIOVANNI, Vanessa, additional, GIANNINI, Andrea, additional, DI DONATO, Violante, additional, PALAIA, Innocenza, additional, PERNIOLA, Giorgia, additional, GIANCOTTI, Antonella, additional, MUZII, Ludovico, additional, and BENEDETTI PANICI, Pierluigi, additional

Published
2021
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21. The role of the sentinel lymph node in vulvar cancer

Author

Giannini, Andrea, primary, D'''''Oria, Ottavia, additional, Santangelo, Giusi, additional, Allegrini, Carlo M., additional, Caruso, Giuseppe, additional, Di Pinto, Anna, additional, Perniola, Giorgia, additional, Palaia, Innocenza, additional, Monti, Marco, additional, Muzii, Ludovico, additional, Benedetti Panici, Pierluigi, additional, and Di Donato, Violante, additional

Published
2021
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22. Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer: The Role of Immune-related Factors

Author

PALAIA, INNOCENZA, primary, TOMAO, FEDERICA, additional, DI PINTO, ANNA, additional, PERNAZZA, ANGELINA, additional, SANTANGELO, GIUSI, additional, D’ALESSANDRIS, NICOLETTA, additional, MANGANARO, LUCIA, additional, ARNO, ANTONIO, additional, DONATO, VIOLANTE DI, additional, PERNIOLA, GIORGIA, additional, DELLA ROCCA, CARLO, additional, and PANICI, PIERLUIGI BENEDETTI, additional

Published
2021
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23. Fertility-sparing surgery for women with stage I cervical cancer of 4 cm or larger: a systematic review

Author

Di Donato, Violante, primary, Caruso, Giuseppe, additional, Sassu, Carolina Maria, additional, Santangelo, Giusi, additional, Bogani, Giorgio, additional, Plotti, Francesco, additional, Sorbi, Flavia, additional, Perniola, Giorgia, additional, Palaia, Innocenza, additional, Terrin, Gianluca, additional, Angioli, Roberto, additional, Benedetti Panici, Pierluigi, additional, and Muzii, Ludovico, additional

Published
2021
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27. Immune Checkpoint Inhibitors: A Promising Choice for Endometrial Cancer Patients?

Author

Musacchio, Lucia, primary, Boccia, Serena Maria, additional, Caruso, Giuseppe, additional, Santangelo, Giusi, additional, Fischetti, Margherita, additional, Tomao, Federica, additional, Perniola, Giorgia, additional, Palaia, Innocenza, additional, Muzii, Ludovico, additional, Pignata, Sandro, additional, Benedetti Panici, Pierluigi, additional, and Di Donato, Violante, additional

Published
2020
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28. Targeting cervical cancer: Is there a role for poly (ADP‐ribose) polymerase inhibition?

Author

Tomao, Federica, primary, Santangelo, Giusi, additional, Musacchio, Lucia, additional, Di Donato, Violante, additional, Fischetti, Margherita, additional, Giancotti, Antonella, additional, Perniola, Giorgia, additional, Petrella, Maria Cristina, additional, Monti, Marco, additional, Palaia, Innocenza, additional, Muzii, Ludovico, additional, and Benedetti Panici, Pierluigi, additional

Published
2020
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29. Does Hormone Replacement Therapy Impact the Prognosis in Endometrial Cancer Survivors? A Systematic Review

Author

Di Donato, Violante, primary, Palaia, Innocenza, additional, D'Aniello, Debora, additional, Musacchio, Lucia, additional, Santangelo, Giusi, additional, Di mauro, Federica, additional, Di Pinto, Anna, additional, Musella, Angela, additional, Fischetti, Margherita, additional, Tomao, Federica, additional, Perniola, Giorgia, additional, and Benedetti Panici, Pierluigi, additional

Published
2020
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30. Evaluation of Parametrial Status in Locally Advanced Cervical Cancer Patients after Neoadjuvant Chemotherapy: A Prospective Study on Diagnostic Accuracy of Three-Dimensional Transvaginal Ultrasound

Author

Perniola, Giorgia, primary, Fischetti, Margherita, additional, Tomao, Federica, additional, Di Donato, Violante, additional, Palaia, Innocenza, additional, Santangelo, Giusi, additional, Lecce, Francesca, additional, Piccioni, Maria Grazia, additional, Muzii, Ludovico, additional, and Benedetti Panici, Pierluigi, additional

Published
2020
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31. The use of misoprostol and mifepristone in second trimester interruption of pregnancy: State of art

Author

Montis, Marco, primary, Tibaldi, Valentina, additional, Santangelo, Giusi, additional, Pajno, Cristina, additional, Corno, Sara, additional, D'aniello, Debora, additional, Giannini, Andrea, additional, Clemente, Francesco, additional, Bracchi, Carlotta, additional, Colagiovanni, Vanessa, additional, Perniola, Giorgia, additional, Palaia, Innocenza, additional, Di Donato, Violante, additional, Musella, Angela, additional, Brunelli, Roberto, additional, Giancotti, Antonella, additional, Muzii, Ludovico, additional, and Benedetti Panici, Pierluigi, additional

Published
2020
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34. Value of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Sentinel Lymph Node Biopsy in Endometrial Cancer Patients: A Prospective Study.

Author

Palaia, Innocenza, Di Donato, Violante, Musella, Angela, Di Pinto, Anna, Santangelo, Giusi, Petriglia, Giuliano, and Benedetti Panici, Pierluigi

Subjects
SENTINEL lymph node biopsy, POSITRON emission tomography computed tomography, LYMPHADENECTOMY, ENDOMETRIAL surgery, COMPUTED tomography, ENDOMETRIAL cancer, MORBID obesity, SENTINEL lymph nodes
Abstract

The aim of this study is to define the role of preoperative positron emission tomography/computed tomography (PET/CT) scan and sentinel lymph node (SLN) biopsy for nodal metastasis detection in Endometrial Cancer (EC) patients. From January 2014 to August 2016 patients affected by EC scheduled for surgery underwent PET/CT scan and SLN mapping with indocyanine-green. Patients with suspicious lymph nodes at FDG-PET/CT underwent selective pelvic lymphadenectomy. In case of undetectable SLN, no further lymphadenectomy was performed if PET/CT scan was negative. Basic descriptive statistics were used to describe outcomes. A total of 83 patients were enrolled in the study. PET/CT scan was suggestive of nodal involvement in 15 patients. SLN were detected bilaterally in 78% of patients. Detection rate was influenced by patients' BMI and surgical learning curve. Five patients were node-positive: all of these had hypermetabolic nodes on PET/CT scan; in one patient SLN was not detected. Ten out of 15 patients with suspicious nodes on PET/CT scan were node-negative. After a median follow up of 24 months all patients are alive. Four patients experienced recurrent disease. No nodal relapse was recorded. Lymphatic mapping with sentinel node biopsy is able to reduce morbidity associated with pelvic lymphadenectomy. Sentinel node assessment is a feasible and appealing procedure and should be performed in a specialized center. Detection rate strongly improves with learning curve, while is reduced in morbidly obese patients. PET/CT scan shows high sensitivity but moderate specificity for nodal metastasis and may help to avoid nodal dissection in patients with sentinel node mapping failure. [ABSTRACT FROM AUTHOR]

Published
2021
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38. The role of the sentinel lymph node in vulvar cancer.

Author

GIANNINI, Andrea, D'ORIA, Ottavia, SANTANGELO, Giusi, ALLEGRINI, Carlo M., CARUSO, Giuseppe, DI PINTO, Anna, PERNIOLA, Giorgia, PALAIA, Innocenza, MONTI, Marco, MUZII, Ludovico, BENEDETTI PANICI, Pierluigi, and DI DONATO, Violante

Subjects
GYNECOLOGY periodicals, SENTINEL lymph nodes, VULVAR cancer
Published
2020
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39. Intraperitoneal Chemotherapy: A Strategy for the Treatment of Refractory Ascites in Recurrent Endometrial Cancer Patients – Three Case Reports and Review of the Literature.

Author

Perniola, Giorgia, Santangelo, Giusi, Palaia, Innocenza, Musella, Angela, Tomao, Federica, Di Donato, Violante, Muzii, Ludovico, and Benedetti Panici, Pierluigi

Subjects
*DIAGNOSIS of dyspnea, *FATIGUE prevention, *ANOREXIA nervosa, *ASCITES, *CANCER chemotherapy, *CANCER patients, *CANCER relapse, *DOXORUBICIN, *INTRAPERITONEAL injections, *PALLIATIVE treatment, *PARACENTESIS, *PLATINUM compounds, *QUALITY of life, *TERPENES, *TUMOR antigens, *TUMOR classification, *ENDOMETRIAL tumors, *DISEASE progression, *SALVAGE therapy
Abstract

Background: Endometrial cancer currently represents the most frequent gynecologic malignancy in Western countries, and the seventh most common cancer in women. For advanced-stage disease, the recurrence risk is high, and the site of the relapse is heterogeneous with localized or spread peritoneal disease. There are few therapeutic strategies, and the quality of life is poor. Cases Presentation: We present 3 cases of peritoneal-spread recurrences of endometrial cancer in patients with advanced stage at diagnosis. The patients had been subjected to multiple lines of chemotherapy including re-challenging with platinum regimens, pegylated liposomal doxorubicin, and taxane, with progression of disease. These patients came to us with abdominal distension, dyspnea, elevated CA 125, and presence of ascites. After paracentesis with a single administration of intraperitoneal chemotherapy based on carboplatin, all 3 patients showed improvement in their quality of life and breathing as well as reduction of fatigue and anorexia. No complications occurred. Conclusion: Although only 3 cases are reported, the exceptional results and the absence of side effects observed strongly warrant future trials to investigate the role intraperitoneal chemotherapy can have both as palliative treatment of refractory ascites and as salvage therapy in advanced endometrial cancer. [ABSTRACT FROM AUTHOR]

Published
2020
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42. Implementation of the Four-Category Classification of Cesarean Section Urgency in Clinical Practice. A Prospective Study.

Author

Maneschi, Francesco, Biccirè, Desiree, Santangelo, Giusi, Perrone, Seila, Scaini, alberto, and Cosentino, Carmine

Subjects
UMBILICAL cord abnormalities, DISEASES in women, ACIDOLYSIS, CHEMICAL reactions, FETAL abnormalities, CESAREAN section, COMPARATIVE studies, DELIVERY (Obstetrics), LONGITUDINAL method, RESEARCH methodology, MEDICAL care, MEDICAL cooperation, PATIENTS, RESEARCH, TIME, EVALUATION research
Abstract

Purpose: This study is aimed at investigating the clinical efficacy of the 4-category classification of urgent cesarean section.Methods: Women giving birth from September 2012 to December 2014 were prospectively investigated. Urgency C-section categories were color-coded: red - maternal/fetal life threat; yellow - maternal/fetal compromise, not life-threatening; and green - early delivery necessary. Results were audited.Results: A total of 4,754 women gave birth in the period considered, 1,313 (27.6%) with C-section of which 867 were urgent. The code was red in 0.98% of women, and 91.5% of newborns were delivered ≤30'; yellow in 5.1%; and green in 11.7%. The mean decision-to-delivery interval (DDI) ± SD was 19.6 ± 9.5 min, 36.6 ± 15.3 (p < 0.01), and 80.3 ± 52.8 (p < 0.01), respectively; and mean umbilical pH was 7.24 ± 0.10, 7.29 ± 0.08 (p < 0.05), and 7.33 ± 0.04 (p < 0.01) in the red, yellow, and green groups, respectively. Two (4.2%) red and 4 (2.2%) yellow newborns were acidotic. Mean DDI ± SD decreased from 21.7 ± 9.7 min in the period September 2012 to February 2013 to 17.4 ± 9.7 min in the period February to December 2014 (p = NS).Conclusions: Four-category classification led to achieving the target time in >90% of category 1 emergency C-sections, and stratified newborns with significantly different acidosis levels. [ABSTRACT FROM AUTHOR]

Published
2017
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43. Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

Author

Giorgio Bogani, Violante Di Donato, Giovanni Scambia, Fabio Landoni, Fabio Ghezzi, Ludovico Muzii, Pierluigi Benedetti Panici, Francesco Raspagliesi, Jvan Casarin, Giampaolo Di Martino, Tommaso Grassi, Anna Myriam Perrone, Pierandrea De Iaco, Francesco Multinu, Roberto Berretta, Vito A. Capozzi, Errico Zupi, Gabriele Centini, Antonio Pellegrino, Silvia Corso, Guido Stevenazzi, Anna Chiara Boschi, Giuseppe Comerci, Pantaleo Greco, Gennaro Scutiero, Francesco Sopracordevole, Giorgio Giorda, Mariasole Fichera, Tommaso Simoncini, Marta Caretto, Enrico Sartori, Federico Ferrari, Antonio Cianci, Giuseppe Sarpietro, Maria Grazia Matarazzo, Pierluigi Giampaolino, Giuseppe Bifulco, Michele Morelli, Michele Di Dio, Annamaria Ferrero, Nicoletta Biglia, Fabio Barra, Simone Ferrero, Stefano Cianci, Vito Chiantera, Giulio Sozzi, Alfredo Ercoli, Sergio Schettini, Teresa Orlando, Francesco G. Cannone, Giuseppe Ettore, Andrea Puppo, Elena Olearo, Umberto Leone Roberti Maggiore, Valeria Artuso, Innocenza Palaia, Giorgia Perniola, Rossana Tripodi, Tullio Golia D'Augè, Ilaria Cuccu, Margherita Fischetti, Giusi Santangelo, Assunta Casorelli, Andrea Giannini, Ottavia D’Oria, Giuseppe Vizzielli, Stefano Restaino, Alice Bergamini, Luca Bocciolone, Francesco Plotti, Roberto Angioli, Giulia Mantovani, Marcello Ceccaroni, Chiara Cassini, Mattia Dominoni, Laura Giambanco, Silvia Amodeo, Livio Leo, Raphaël Thommaset, Diego Raimondo, Renato Seracchioli, Mario Malzoni, Francesca Falcone, Franco Gorlero, Martina Di Luca, Enrico Busato, Sami Kilzie, Andrea Dell'Acqua, Giovanna Scarfone, Paolo Vercellini, Marco Petrillo, Giampiero Capobianco, Andrea Ciavattini, Liliana Mereu, Paolo Scollo, Flavia Sorbi, Massimiliano Fambrini, Federico Romano, Giuseppe Ricci, Giuseppe Trojano, Gianluca Raffaello Damiani, Roberto Consonni, Nadia Di Lorenzo, Antonio Lippolis, Raffaele Tinelli, Lorenzo Aguzzoli, Vincenzo D. Mandato, Stefano Palomba, Marcello Tripodi, Davide Calandra, Franco Pellegrini, Fulvio Zullo, Daniela Surico, Valentino Remorgida, Francesco Ruscitto, Paolo Beretta, Enrico Vizza, Bogani, Giorgio, Donato, Violante Di, Scambia, Giovanni, Landoni, Fabio, Ghezzi, Fabio, Muzii, Ludovico, Panici, Pierluigi Benedetti, Raspagliesi, Francesco, Giampaolino, Pierluigi, Bogani, G, Donato, V, Scambia, G, Landoni, F, Ghezzi, F, Muzii, L, Panici, P, Raspagliesi, F, Casarin, J, Di Martino, G, Grassi, T, Perrone, A, De Iaco, P, Multinu, F, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Boschi, A, Comerci, G, Greco, P, Scutiero, G, Sopracordevole, F, Giorda, G, Fichera, M, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Giampaolino, P, Bifulco, G, Morelli, M, Dio, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Cianci, S, Chiantera, V, Sozzi, G, Ercoli, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Olearo, E, Leone Roberti Maggiore, U, Artuso, V, Palaia, I, Perniola, G, Tripodi, R, D'Auge, T, Cuccu, I, Fischetti, M, Santangelo, G, Casorelli, A, Giannini, A, D'Oria, O, Vizzielli, G, Restaino, S, Bergamini, A, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassini, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thommaset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Falcone, F, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Capobianco, G, Ciavattini, A, Mereu, L, Scollo, P, Sorbi, F, Fambrini, M, Romano, F, Ricci, G, Trojano, G, Damiani, G, Consonni, R, Di Lorenzo, N, Lippolis, A, Tinelli, R, Aguzzoli, L, Mandato, V, Palomba, S, Tripodi, M, Calandra, D, Pellegrini, F, Zullo, F, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Vizza, E, Casarin, Jvan, Di Martino, Giampaolo, Grassi, Tommaso, Perrone, Anna Myriam, De Iaco, Pierandrea, Multinu, Francesco, Berretta, Roberto, Capozzi, Vito A., Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Scutiero, Gennaro, Sopracordevole, Francesco, Giorda, Giorgio, Fichera, Mariasole, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Bifulco, Giuseppe, Morelli, Michele, Dio, Michele Di, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Cianci, Stefanoa, Chiantera, Vitoa, Ercoli, Alfredo, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G., Ettore, Giuseppe, Puppo, Andrea, Olearo, Elena, Maggiore, Umberto Leone Roberti, Artuso, Valeria, Palaia, Innocenza, Perniola, Giorgia, Tripodi, Rosanna, D'Augè, Tullio Golia, Cuccu, Ilaria, Fischetti, Margherita, Santangelo, Giusi, Casorelli, Assunta, Giannini, Andrea, D’Oria, Ottvaio, Vizzielli, Giuseppe, Restaino, Stefano, Bergamini, Alice, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassini, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thommaset, Raphaël, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Falcone, Francesca, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Capobianco, Giampiero, Ciavattini, Andrea, Mereu, Liliana, Scollo, Paolo, Sorbi, Flavia, Fambrini, Massimiliano, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Damiani, Gianluca Raffaello, Consonni, Roberto, Di Lorenzo, Nadia, Lippolis, Antonio, Tinelli, Raffaele, Aguzzoli, Lorenzo, Mandato, Vincenzo D., Palomba, Stefano, Tripodi, Marcello, Calandra, Davide, Pellegrini, Franco, Zullo, Fulvio, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, and Vizza, Enrico.

Subjects
Complications, Obstetrics and Gynecology, Uterine Cervical Neoplasms, Hysterectomy, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Oncology, Retrospective Studie, Laparoscopy, Morbidity, Radical hysterectomy, Female, Humans, Neoplasm Staging, Retrospective Studies, Complication, Human
Abstract

Background. To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods. This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016-06/01/2018) and after (period II: 01/01/2019-06/01/2021) the publication of the results of the LACC trial. Results. Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions. The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity. (c) 2022 Elsevier Inc. All rights reserved.

Published
2022

44. Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Author

Giorgio Bogani, Luca Lalli, Francesco Sopracordevole, Andrea Ciavattini, Alessandro Ghelardi, Tommaso Simoncini, Francesco Plotti, Jvan Casarin, Maurizio Serati, Ciro Pinelli, Alice Bergamini, Barbara Gardella, Andrea Dell’Acqua, Ermelinda Monti, Paolo Vercellini, Innocenza Palaia, Giorgia Perniola, Margherita Fischetti, Giusi Santangelo, Alice Fracassi, Giovanni D’Ippolito, Lorenzo Aguzzoli, Vincenzo Dario Mandato, Luca Giannella, Cono Scaffa, Francesca Falcone, Chiara Borghi, Mario Malzoni, Andrea Giannini, Maria Giovanna Salerno, Viola Liberale, Biagio Contino, Cristina Donfrancesco, Michele Desiato, Anna Myriam Perrone, Giulia Dondi, Pierandrea De Iaco, Simone Ferrero, Giuseppe Sarpietro, Maria G. Matarazzo, Antonio Cianci, Stefano Cianci, Sara Bosio, Simona Ruisi, Lavinia Mosca, Raffaele Tinelli, Rosa De Vincenzo, Gian Franco Zannoni, Gabriella Ferrandina, Marco Petrillo, Giampiero Capobianco, Salvatore Dessiole, Annunziata Carlea, Fulvio Zullo, Barbara Muschiato, Stefano Palomba, Stefano Greggi, Arsenio Spinillo, Fabio Ghezzi, Nicola Colacurci, Roberto Angioli, Pierluigi Benedetti Panici, Ludovico Muzii, Giovanni Scambia, Francesco Raspagliesi, Violante Di Donato, Bogani, G., Lalli, L., Sopracordevole, F., Ciavattini, A., Ghelardi, A., Simoncini, T., Plotti, F., Casarin, J., Serati, M., Pinelli, C., Bergamini, A., Gardella, B., Dell'Acqua, A., Monti, E., Vercellini, P., Palaia, I., Perniola, G., Fischetti, M., Santangelo, G., Fracassi, A., D'Ippolito, G., Aguzzoli, L., Mandato, V. D., Giannella, L., Scaffa, C., Falcone, F., Borghi, C., Malzoni, M., Giannini, A., Salerno, M. G., Liberale, V., Contino, B., Donfrancesco, C., Desiato, M., Perrone, A. M., Dondi, G., De Iaco, P., Ferrero, S., Sarpietro, G., Matarazzo, M. G., Cianci, A., Cianci, S., Bosio, S., Ruisi, S., Mosca, L., Tinelli, R., De Vincenzo, R., Zannoni, G. F., Ferrandina, G., Petrillo, M., Capobianco, G., Dessiole, S., Carlea, A., Zullo, F., Muschiato, B., Palomba, S., Greggi, S., Spinillo, A., Ghezzi, F., Colacurci, N., Angioli, R., Panici, P. B., Muzii, L., Scambia, G., Raspagliesi, F., Di Donato, V., Bogani, Giorgio, Lalli, Luca, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Palaia, Innocenza, Perniola, Giorgia, Fischetti, Margherita, Santangelo, Giusi, Fracassi, Alice, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Cianci, Stefano, Bosio, Sara, Ruisi, Simona, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa, Zannoni, Gian Franco, Ferrandina, Gabriella, Petrillo, Marco, Capobianco, Giampiero, Dessiole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Muschiato, Barbara, Palomba, Stefano, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Angioli, Roberto, Benedetti Panici, Pierluigi, Muzii, Ludovico, Scambia, Giovanni, Raspagliesi, Francesco, and Di Donato, Violante

Subjects
Pharmacology, conization, HPV, Settore MED/40 - GINECOLOGIA E OSTETRICIA, recurrence, Infectious Diseases, Drug Discovery, Immunology, LEEP, Pharmacology (medical), cervical dysplasia
Abstract

Background: Cervical dysplasia persistence/recurrence has a great impact on women’s health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. Methods: This is a retrospective multi-institutional study based on charts of consecutive patients undergoing conization between 1 January 2010 and 31 December 2014. A nomogram assessing the importance of different variables was built. A cohort of patients treated between 1 January 2015 and 30 June 2016 was used to validate the nomogram. Results: A total of 2966 patients undergoing primary conization were analyzed. The median (range) patient age was 40 (18–89) years. At 5-year of follow-up, 6% of patients (175/2966) had developed a persistent/recurrent cervical dysplasia. Median (range) recurrence-free survival was 18 (5–52) months. Diagnosis of CIN3, presence of HR-HPV types, positive endocervical margins, HPV persistence, and the omission of HPV vaccination after conization increased significantly and independently of the risk of developing cervical dysplasia persistence/recurrence. A nomogram weighting the impact of all variables was built with a C-Index of 0.809. A dataset of 549 patients was used to validate the nomogram, with a C-index of 0.809. Conclusions: The present nomogram represents a useful tool for counseling women about their risk of persistence/recurrence after primary conization. HPV vaccination after conization is associated with a reduced risk of CIN2+.

Published
2022

45. Assessing the role of low volume disease in endometrial cancer.

Author

Bogani G, Palaia I, Perniola G, Fracassi A, Cuccu I, Golia D'Auge T, Casorelli A, Santangelo G, Fischetti M, Muzii L, Benedetti Panici P, and Di Donato V

Subjects
Female, Humans, Lymph Node Excision, Lymph Nodes pathology, Neoplasm Staging, Sentinel Lymph Node Biopsy, Endometrial Neoplasms pathology, Sentinel Lymph Node pathology
Abstract

The role of retroperitoneal staging in endometrial cancer is still unclear. Although the prognostic value of lymphadenectomy has been demonstrated no data support the therapeutic value of nodal dissection. Sentinel node mapping represents an evolution of lymphadenectomy. Sentinel node mapping allows a more accurate identification of low-volume diseases (i.e., micrometastasis and isolated tumor cells) that are not always detectable via conventional histopathological evaluation. Adjuvant therapy might play a role in patients with low-volume disease. However, the presence of isolated tumor cells alone seems to not impact outcomes of endometrioid endometrial cancer patients. Hence, the choice to deliver adjuvant therapies has to be tailored based on uterine factors only. The introduction of molecular and genomic profiling would be useful in selecting appropriate surgical and adjuvant treatments. The molecular-integrated risk profile should be integrated in clinical practice to overcome the need of retroperitoneal staging (in case of non-bulky nodes) in patients at low risk., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Published
2022
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