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498 results on '"Santangelo, F"'

1. 131P Safety and clinical efficacy of roginolisib (IOA-244): The first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ)

Author

Di Giacomo, A.M., primary, Simonelli, M., additional, Santangelo, F., additional, Amato, G., additional, Simonetti, E., additional, Graham, J., additional, Lahn, M., additional, Di Conza, G., additional, Hammett, T., additional, Zorrilla, R., additional, Kaur, P., additional, Ziyang, T., additional, Lakshmikanth, T., additional, Brodin, P., additional, Occhipinti, M., additional, Carlo-Stella, C., additional, Santoro, A., additional, Spiliopoulou, P., additional, Evans, T.R.J., additional, and Maio, M., additional

Published
2023
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2. Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke

Author

Valente, A, Mariani, J, Seminara, S, Tettamanti, M, Pignataro, G, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Diamanti, S, Vigano, M, Santangelo, F, Zoia, C, Rodriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Di Santo, C, Cuomo, O, Gullotta, G, Butti, E, Bagetta, G, Martino, G, De Simoni, M, Ferrarese, C, Fumagalli, S, Beretta, S, Valente A., Mariani J., Seminara S., Tettamanti M., Pignataro G., Perego C., Sironi L., Pedata F., Amantea D., Bacigaluppi M., Vinciguerra A., Diamanti S., Vigano M., Santangelo F., Zoia C. P., Rodriguez-Menendez V., Castiglioni L., Rzemieniec J., Dettori I., Bulli I., Coppi E., Di Santo C., Cuomo O., Gullotta G. S., Butti E., Bagetta G., Martino G., De Simoni M. -G., Ferrarese C., Fumagalli S., Beretta S., Valente, A, Mariani, J, Seminara, S, Tettamanti, M, Pignataro, G, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Diamanti, S, Vigano, M, Santangelo, F, Zoia, C, Rodriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Di Santo, C, Cuomo, O, Gullotta, G, Butti, E, Bagetta, G, Martino, G, De Simoni, M, Ferrarese, C, Fumagalli, S, Beretta, S, Valente A., Mariani J., Seminara S., Tettamanti M., Pignataro G., Perego C., Sironi L., Pedata F., Amantea D., Bacigaluppi M., Vinciguerra A., Diamanti S., Vigano M., Santangelo F., Zoia C. P., Rodriguez-Menendez V., Castiglioni L., Rzemieniec J., Dettori I., Bulli I., Coppi E., Di Santo C., Cuomo O., Gullotta G. S., Butti E., Bagetta G., Martino G., De Simoni M. -G., Ferrarese C., Fumagalli S., and Beretta S.

Abstract

Multicentre preclinical randomized controlled trials (pRCTs) are a valuable tool to improve experimental stroke research, but are challenging and therefore underused. A common challenge regards the standardization of procedures across centres. We here present the harmonization phase for the quantification of sensorimotor deficits by composite neuroscore, which was the primary outcome of two multicentre pRCTs assessing remote ischemic conditioning in rodent models of ischemic stroke. Ischemic stroke was induced by middle cerebral artery occlusion for 30, 45 or 60 min in mice and 50, 75 or 100 min in rats, allowing sufficient variability. Eleven animals per species were video recorded during neurobehavioural tasks and evaluated with neuroscore by eight independent raters, remotely and blindly. We aimed at reaching an intraclass correlation coefficient (ICC) ≥0.60 as satisfactory interrater agreement. After a first remote training we obtained ICC = 0.50 for mice and ICC = 0.49 for rats. Errors were identified in animal handling and test execution. After a second remote training, we reached the target interrater agreement for mice (ICC = 0.64) and rats (ICC = 0.69). In conclusion, a multi-step, online harmonization phase proved to be feasible, easy to implement and highly effective to align each centre’s behavioral evaluations before project’s interventional phase.

Published
2023

3. Hypoglycemic Encephalopathy Manifesting with Cortical Hemichorea-Hemiballismus Syndrome: A Case Report

Author

Pasini, F, Karantzoulis, A, Fanella, G, Brovelli, F, Iacobucci, D, Aprea, V, Storti, B, Santangelo, F, Canonico, F, Remida, P, Ferrarese, C, Brighina, L, Pasini F., Karantzoulis A., Fanella G., Brovelli F., Iacobucci D., Aprea V., Storti B., Santangelo F., Canonico F., Remida P., Ferrarese C., Brighina L., Pasini, F, Karantzoulis, A, Fanella, G, Brovelli, F, Iacobucci, D, Aprea, V, Storti, B, Santangelo, F, Canonico, F, Remida, P, Ferrarese, C, Brighina, L, Pasini F., Karantzoulis A., Fanella G., Brovelli F., Iacobucci D., Aprea V., Storti B., Santangelo F., Canonico F., Remida P., Ferrarese C., and Brighina L.

Abstract

Hyper-/hypoglycemic states are rare but well-established causes of hyperkinetic movements, including chorea and ballismus, usually associated with brain lesions in the basal ganglia. We report a case of hemichorea-hemiballismus (HCHB) syndrome that developed after a severe hypoglycemic episode in a 71-year-old man with poorly controlled type 2 diabetes mellitus. Uncommonly, brain MRI showed contralateral cortical-subcortical T2 and T2-FLAIR-hyperintense frontoparietal lesions, with cingulate gyrus involved, while the basal ganglia were unaffected. In patients with hypoglycemic encephalopathy associated with cortical lesions, the long-term prognosis is usually poor. Nevertheless, in our patient, the dyskinesias and the cerebral lesions progressively regressed by achieving good glycemic control. After four and 12 months, the patient's neurological examination was normal. To our knowledge, this is the first evidence of hypoglycemic etiology of cortical HCHB syndrome, supporting recent theories that cortical circuitries may independently contribute to the pathogenesis of chorea and ballismus. This is also the first report of cingulate gyrus involvement in hypoglycemic encephalopathy. Finally, this case may indicate that a subset of patients with cortical lesions due to hypoglycemia could present a good clinical outcome, likely depending on the size of the lesions and the duration and severity of the hypoglycemic episode.

Published
2023

4. The Political Culture of Coinage

Author

Termeer, M.K., Balbo, M., Santangelo, F., Balbo, M., and Santangelo, F.

Subjects
Europe in a Changing World, The Ancient World
Abstract

The introduction of the denarius system during the Second Punic War represents a major step in the monetization of the Roman world. The following century saw a great influx of wealth and growth of the urban population on the Italian peninsula. This chapter analyzes how the introduction of the denarius system and its subsequent development reflect and constitute important developments in Rome’s political culture, focusing on two main changes: the introduction of the denarius system itself, and the appearance of private denarius types in the 130s, which was accompanied by a decrease in bronze coinage production. Two main questions are investigated. First, what do the coins tell us about political decision-making processes, and the way coinage helped to define the res publica? Second, who was the audience for the messages on the coins, and how do they relate to the Roman political body? The introduction of a fixed “state emblem” on the denarius coinage was an innovative move away from previous coin-producing practices, and can be read in relation to the conscious development of a Roman civic identity. The change to private types implies a decrease in the importance of Roman civic identity as communicated on coins, and more attention for the families and individuals that constitute Rome as a political entity. This change was restricted to silver coins, however. The bronze coins tell a different story: the Roman types stay the same, but production decreases, while a variety of local productions on the Italian peninsula are widely used.

Published
2022

5. SARS-CoV-2 infection and acute ischemic stroke in Lombardy, Italy

Author

Pezzini, A, Grassi, M, Silvestrelli, G, Locatelli, M, Rifino, N, Beretta, S, Gamba, M, Raimondi, E, Giussani, G, Carimati, F, Sangalli, D, Corato, M, Gerevini, S, Masciocchi, S, Cortinovis, M, La Gioia, S, Barbieri, F, Mazzoleni, V, Pezzini, D, Bonacina, S, Pilotto, A, Benussi, A, Magoni, M, Premi, E, Prelle, A, Agostoni, E, Palluzzi, F, De Giuli, V, Magherini, A, Roccatagliata, D, Vinciguerra, L, Puglisi, V, Fusi, L, Diamanti, S, Santangelo, F, Xhani, R, Pozzi, F, Grampa, G, Versino, M, Salmaggi, A, Marcheselli, S, Cavallini, A, Giossi, A, Censori, B, Ferrarese, C, Ciccone, A, Sessa, M, Padovani, A, Pezzini A., Grassi M., Silvestrelli G., Locatelli M., Rifino N., Beretta S., Gamba M., Raimondi E., Giussani G., Carimati F., Sangalli D., Corato M., Gerevini S., Masciocchi S., Cortinovis M., La Gioia S., Barbieri F., Mazzoleni V., Pezzini D., Bonacina S., Pilotto A., Benussi A., Magoni M., Premi E., Prelle A. C., Agostoni E. C., Palluzzi F., De Giuli V., Magherini A., Roccatagliata D. V., Vinciguerra L., Puglisi V., Fusi L., Diamanti S., Santangelo F., Xhani R., Pozzi F., Grampa G., Versino M., Salmaggi A., Marcheselli S., Cavallini A., Giossi A., Censori B., Ferrarese C., Ciccone A., Sessa M., Padovani A., Pezzini, A, Grassi, M, Silvestrelli, G, Locatelli, M, Rifino, N, Beretta, S, Gamba, M, Raimondi, E, Giussani, G, Carimati, F, Sangalli, D, Corato, M, Gerevini, S, Masciocchi, S, Cortinovis, M, La Gioia, S, Barbieri, F, Mazzoleni, V, Pezzini, D, Bonacina, S, Pilotto, A, Benussi, A, Magoni, M, Premi, E, Prelle, A, Agostoni, E, Palluzzi, F, De Giuli, V, Magherini, A, Roccatagliata, D, Vinciguerra, L, Puglisi, V, Fusi, L, Diamanti, S, Santangelo, F, Xhani, R, Pozzi, F, Grampa, G, Versino, M, Salmaggi, A, Marcheselli, S, Cavallini, A, Giossi, A, Censori, B, Ferrarese, C, Ciccone, A, Sessa, M, Padovani, A, Pezzini A., Grassi M., Silvestrelli G., Locatelli M., Rifino N., Beretta S., Gamba M., Raimondi E., Giussani G., Carimati F., Sangalli D., Corato M., Gerevini S., Masciocchi S., Cortinovis M., La Gioia S., Barbieri F., Mazzoleni V., Pezzini D., Bonacina S., Pilotto A., Benussi A., Magoni M., Premi E., Prelle A. C., Agostoni E. C., Palluzzi F., De Giuli V., Magherini A., Roccatagliata D. V., Vinciguerra L., Puglisi V., Fusi L., Diamanti S., Santangelo F., Xhani R., Pozzi F., Grampa G., Versino M., Salmaggi A., Marcheselli S., Cavallini A., Giossi A., Censori B., Ferrarese C., Ciccone A., Sessa M., and Padovani A.

Abstract

Objective: To characterize patients with acute ischemic stroke related to SARS-CoV-2 infection and assess the classification performance of clinical and laboratory parameters in predicting in-hospital outcome of these patients. Methods: In the setting of the STROKOVID study including patients with acute ischemic stroke consecutively admitted to the ten hub hospitals in Lombardy, Italy, between March 8 and April 30, 2020, we compared clinical features of patients with confirmed infection and non-infected patients by logistic regression models and survival analysis. Then, we trained and tested a random forest (RF) binary classifier for the prediction of in-hospital death among patients with COVID-19. Results: Among 1013 patients, 160 (15.8%) had SARS-CoV-2 infection. Male sex (OR 1.53; 95% CI 1.06–2.27) and atrial fibrillation (OR 1.60; 95% CI 1.05–2.43) were independently associated with COVID-19 status. Patients with COVID-19 had increased stroke severity at admission [median NIHSS score, 9 (25th to75th percentile, 13) vs 6 (25th to75th percentile, 9)] and increased risk of in-hospital death (38.1% deaths vs 7.2%; HR 3.30; 95% CI 2.17–5.02). The RF model based on six clinical and laboratory parameters exhibited high cross-validated classification accuracy (0.86) and precision (0.87), good recall (0.72) and F1-score (0.79) in predicting in-hospital death. Conclusions: Ischemic strokes in COVID-19 patients have distinctive risk factor profile and etiology, increased clinical severity and higher in-hospital mortality rate compared to non-COVID-19 patients. A simple model based on clinical and routine laboratory parameters may be useful in identifying ischemic stroke patients with SARS-CoV-2 infection who are unlikely to survive the acute phase.

Published
2022

6. Selective Cerebrospinal Fluid Hypothermia: Bioengineering Development and In Vivo Study of an Intraventricular Cooling Device (V-COOL)

Author

Beretta, S, Versace, A, Fiore, G, Piola, M, Martini, B, Bigiogera, V, Coppadoro, L, Mariani, J, Tinti, L, Pirovano, S, Monza, L, Carone, D, Riva, M, Padovano, G, Galbiati, G, Santangelo, F, Rasponi, M, Padelli, F, Giachetti, I, Aquino, D, Diamanti, S, Librizzi, L, Bruzzone, M, De Curtis, M, Giussani, C, Sganzerla, E, Ferrarese, C, Beretta S., Versace A., Fiore G., Piola M., Martini B., Bigiogera V., Coppadoro L., Mariani J., Tinti L., Pirovano S., Monza L., Carone D., Riva M., Padovano G., Galbiati G., Santangelo F., Rasponi M., Padelli F., Giachetti I., Aquino D., Diamanti S., Librizzi L., Bruzzone M. G., De Curtis M., Giussani C., Sganzerla E. P., Ferrarese C., Beretta, S, Versace, A, Fiore, G, Piola, M, Martini, B, Bigiogera, V, Coppadoro, L, Mariani, J, Tinti, L, Pirovano, S, Monza, L, Carone, D, Riva, M, Padovano, G, Galbiati, G, Santangelo, F, Rasponi, M, Padelli, F, Giachetti, I, Aquino, D, Diamanti, S, Librizzi, L, Bruzzone, M, De Curtis, M, Giussani, C, Sganzerla, E, Ferrarese, C, Beretta S., Versace A., Fiore G., Piola M., Martini B., Bigiogera V., Coppadoro L., Mariani J., Tinti L., Pirovano S., Monza L., Carone D., Riva M., Padovano G., Galbiati G., Santangelo F., Rasponi M., Padelli F., Giachetti I., Aquino D., Diamanti S., Librizzi L., Bruzzone M. G., De Curtis M., Giussani C., Sganzerla E. P., and Ferrarese C.

Abstract

Hypothermia is a promising therapeutic strategy for severe vasospasm and other types of non-thrombotic cerebral ischemia, but its clinical application is limited by significant systemic side effects. We aimed to develop an intraventricular device for the controlled cooling of the cerebrospinal fluid, to produce a targeted hypothermia in the affected cerebral hemisphere with a minimal effect on systemic temperature. An intraventricular cooling device (acronym: V-COOL) was developed by in silico modelling, in vitro testing, and in vivo proof-of-concept application in healthy Wistar rats (n = 42). Cerebral cortical temperature, rectal temperature, and intracranial pressure were monitored at increasing flow rate (0.2 to 0.8 mL/min) and duration of application (10 to 60 min). Survival, neurological outcome, and MRI volumetric analysis of the ventricular system were assessed during the first 24 h. The V-COOL prototyping was designed to minimize extra-cranial heat transfer and intra-cranial pressure load. In vivo application of the V-COOL device produced a flow rate-dependent decrease in cerebral cortical temperature, without affecting systemic temperature. The target degree of cerebral cooling (− 3.0 °C) was obtained in 4.48 min at the flow rate of 0.4 mL/min, without significant changes in intracranial pressure. Survival and neurological outcome at 24 h showed no significant difference compared to sham-treated rats. MRI study showed a transient dilation of the ventricular system (+ 38%) in a subset of animals. The V-COOL technology provides an effective, rapid, selective, and safe cerebral cooling to a clinically relevant degree of − 3.0 °C.

Published
2022

10. Who is really blind in the time of coronavirus: the patient or the doctor? A rare case of Balint’s syndrome

Author

Storti, B, Cereda, D, Balducci, C, Santangelo, F, Ferrarese, C, Appollonio, I, Storti B., Cereda D., Balducci C., Santangelo F., Ferrarese C., Appollonio I., Storti, B, Cereda, D, Balducci, C, Santangelo, F, Ferrarese, C, Appollonio, I, Storti B., Cereda D., Balducci C., Santangelo F., Ferrarese C., and Appollonio I.

Abstract

Background Selective bilateral lesions of the parietal-occipital lobes can lead to an uncommon and incompletely understood clinical entity, Balint' syndrome, which consists of simultanagnosia, oculomotor apraxia, optic ataxia and difficulty in perceiving distances between objects. Case presentation We herein report a rare presentation of Balint's syndrome in a 65-year-old woman suffering from stroke and SARS-CoV2 infection. Conclusion During SARS-CoV2 pandemic, Italian physicians were forced to work with less instrumental diagnostic resources, relying on their clinical knowledge mostly. The aim of this case report is to highlight the importance of performing a precise neurological evaluation, particularly during these challenging times: it might avoid incorrect diagnosis and favour the discovery of rare clinical diseases.

Published
2021

11. Impact of SARS-CoV-2 on reperfusion therapies for acute ischemic stroke in Lombardy, Italy: the STROKOVID network

Author

Pezzini, A, Grassi, M, Silvestrelli, G, Locatelli, M, Rifino, N, Beretta, S, Gamba, M, Raimondi, E, Giussani, G, Carimati, F, Sangalli, D, Corato, M, Gerevini, S, Masciocchi, S, Cortinovis, M, La Gioia, S, Barbieri, F, Mazzoleni, V, Pezzini, D, Bonacina, S, Pilotto, A, Benussi, A, Magoni, M, Premi, E, Prelle, A, Agostoni, E, Palluzzi, F, De Giuli, V, Magherini, A, Roccatagliata, D, Vinciguerra, L, Puglisi, V, Fusi, L, Xhani, R, Pozzi, F, Diamanti, S, Santangelo, F, Grampa, G, Versino, M, Salmaggi, A, Marcheselli, S, Cavallini, A, Giossi, A, Censori, B, Ferrarese, C, Ciccone, A, Sessa, M, Padovani, A, Pezzini A., Grassi M., Silvestrelli G., Locatelli M., Rifino N., Beretta S., Gamba M., Raimondi E., Giussani G., Carimati F., Sangalli D., Corato M., Gerevini S., Masciocchi S., Cortinovis M., La Gioia S., Barbieri F., Mazzoleni V., Pezzini D., Bonacina S., Pilotto A., Benussi A., Magoni M., Premi E., Prelle A. C., Agostoni E. C., Palluzzi F., De Giuli V., Magherini A., Roccatagliata D. V., Vinciguerra L., Puglisi V., Fusi L., Xhani R., Pozzi F., Diamanti S., Santangelo F., Grampa G., Versino M., Salmaggi A., Marcheselli S., Cavallini A., Giossi A., Censori B., Ferrarese C., Ciccone A., Sessa M., Padovani A., Pezzini, A, Grassi, M, Silvestrelli, G, Locatelli, M, Rifino, N, Beretta, S, Gamba, M, Raimondi, E, Giussani, G, Carimati, F, Sangalli, D, Corato, M, Gerevini, S, Masciocchi, S, Cortinovis, M, La Gioia, S, Barbieri, F, Mazzoleni, V, Pezzini, D, Bonacina, S, Pilotto, A, Benussi, A, Magoni, M, Premi, E, Prelle, A, Agostoni, E, Palluzzi, F, De Giuli, V, Magherini, A, Roccatagliata, D, Vinciguerra, L, Puglisi, V, Fusi, L, Xhani, R, Pozzi, F, Diamanti, S, Santangelo, F, Grampa, G, Versino, M, Salmaggi, A, Marcheselli, S, Cavallini, A, Giossi, A, Censori, B, Ferrarese, C, Ciccone, A, Sessa, M, Padovani, A, Pezzini A., Grassi M., Silvestrelli G., Locatelli M., Rifino N., Beretta S., Gamba M., Raimondi E., Giussani G., Carimati F., Sangalli D., Corato M., Gerevini S., Masciocchi S., Cortinovis M., La Gioia S., Barbieri F., Mazzoleni V., Pezzini D., Bonacina S., Pilotto A., Benussi A., Magoni M., Premi E., Prelle A. C., Agostoni E. C., Palluzzi F., De Giuli V., Magherini A., Roccatagliata D. V., Vinciguerra L., Puglisi V., Fusi L., Xhani R., Pozzi F., Diamanti S., Santangelo F., Grampa G., Versino M., Salmaggi A., Marcheselli S., Cavallini A., Giossi A., Censori B., Ferrarese C., Ciccone A., Sessa M., and Padovani A.

Abstract

Whether and how SARS-CoV-2 outbreak affected in-hospital acute stroke care system is still matter of debate. In the setting of the STROKOVID network, a collaborative project between the ten centers designed as hubs for the treatment of acute stroke during SARS-CoV-2 outbreak in Lombardy, Italy, we retrospectively compared clinical features and process measures of patients with confirmed infection (COVID-19) and non-infected patients (non-COVID-19) who underwent reperfusion therapies for acute ischemic stroke. Between March 8 and April 30, 2020, 296 consecutive patients [median age, 74 years (interquartile range (IQR), 62–80.75); males, 154 (52.0%); 34 (11.5%) COVID-19] qualified for the analysis. Time from symptoms onset to treatment was longer in the COVID-19 group [230 (IQR 200.5–270) minutes vs. 190 (IQR 150–245) minutes; p = 0.007], especially in the first half of the study period. Patients with COVID-19 who underwent endovascular thrombectomy had more frequently absent collaterals or collaterals filling ≤ 50% of the occluded territory (50.0% vs. 16.6%; OR 5.05; 95% CI 1.82–13.80) and a lower rate of good/complete recanalization of the primary arterial occlusive lesion (55.6% vs. 81.0%; OR 0.29; 95% CI 0.10–0.80). Post-procedural intracranial hemorrhages were more frequent (35.3% vs. 19.5%; OR 2.24; 95% CI 1.04–4.83) and outcome was worse among COVID-19 patients (in-hospital death, 38.2% vs. 8.8%; OR 6.43; 95% CI 2.85–14.50). Our findings showed longer delays in the intra-hospital management of acute ischemic stroke in COVID-19 patients, especially in the early phase of the outbreak, that likely impacted patients outcome and should be the target of future interventions.

Published
2021

12. 192P Safety and clinical activity of IOA-244: A highly selective phosphoinositide 3-kinase inhibitor delta (PI3Kδ), in a phase I first-in-human (FIH) study

Author

Di Giacomo, A.M., Santangelo, F., Amato, G., E. Simonetti, Graham, J., Lahn, M., van der Veen, L., Hammett, T., Pickering, C.A., Durini, M., Ziyang, T., Lakshmikanth, T., Brodin, P., Occhipinti, M., Simonelli, M., Carlo-Stella, C., Santoro, A., Spiliopoulou, P., Evans, T.R.J., and Maio, M.

Published
2022
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15. Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke

Author

Valente, A., Mariani, J., Seminara, S., Tettamanti, M., Pignataro, G., Perego, C., Sironi, L., Pedata, F., Amantea, D., Bacigaluppi, M., Vinciguerra, A., Diamanti, S., Vigano, M., Santangelo, F., Zoia, C.P., Rodriguez-Menendez, V., Castiglioni, L., Rzemieniec, J., Dettori, I., Bulli, I., Coppi, E., Di Santo, C., Cuomo, O., Gullotta, G.S., Butti, E., Bagetta, G., Martino, G., De Simoni, M.-., Ferrarese, C., Fumagalli, S., and Beretta, S.

Subjects
interrater agreement, Ischemic stroke, neurobehavior, preclinical multicentre trial, quality check, Neurology, Settore BIO/14 - Farmacologia, Settore MED/26 - Neurologia, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract

Multicentre preclinical randomized controlled trials (pRCTs) are a valuable tool to improve experimental stroke research, but are challenging and therefore underused. A common challenge regards the standardization of procedures across centres. We here present the harmonization phase for the quantification of sensorimotor deficits by composite neuroscore, which was the primary outcome of two multicentre pRCTs assessing remote ischemic conditioning in rodent models of ischemic stroke. Ischemic stroke was induced by middle cerebral artery occlusion for 30, 45 or 60 min in mice and 50, 75 or 100 min in rats, allowing sufficient variability. Eleven animals per species were video recorded during neurobehavioural tasks and evaluated with neuroscore by eight independent raters, remotely and blindly. We aimed at reaching an intraclass correlation coefficient (ICC) ≥0.60 as satisfactory interrater agreement. After a first remote training we obtained ICC = 0.50 for mice and ICC = 0.49 for rats. Errors were identified in animal handling and test execution. After a second remote training, we reached the target interrater agreement for mice (ICC = 0.64) and rats (ICC = 0.69). In conclusion, a multi-step, online harmonization phase proved to be feasible, easy to implement and highly effective to align each centre’s behavioral evaluations before project’s interventional phase.

Published
2023

16. 139P First-in-human (FIH), pharmacokinetic (PK) and pharmacodynamic (PD) study of IOA-244, a phosphoinositide 3-kinase delta (PI3Kδ) inhibitor, in patients with advanced metastatic mesothelioma, uveal and cutaneous melanoma

Author

Di Giacomo, A.M., primary, Santangelo, F., additional, Amato, G., additional, Simonetti, E., additional, Graham, J., additional, Lahn, M., additional, Zorilla, R., additional, van der Veen, L., additional, Johnson, Z., additional, Pickering, C., additional, Maréchal, E., additional, Blanco, J., additional, Durini, M., additional, Gufford, B., additional, Lakshmikanth, T., additional, Brodin, P., additional, Spiliopoulou, P., additional, Evans, T.R.J., additional, and Maio, M., additional

Published
2021
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18. Due volumi collettivi su Livio

Author

Santangelo, Federico

Subjects
Greek language and literature. Latin language and literature, PA, History of the Greco-Roman World, DE1-100
Abstract

Recensione di Baldo, G.; Beltramini, L. (a cura di) (2019). ‘A primordio urbis’. Un itinerario per gli studi liviani. Turnhout: Brepols, 572 pp. GIF Bibliotheca 19 e Baldo, G.; Beltramini, L. (a cura di) (2021). ‘Livius noster’. Tito Livio e la sua eredità. Turnhout: Brepols, 901 pp. GIF Bibliotheca 26.

Published
2024
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20. Multicentre translational Trial of Remote Ischaemic Conditioning in Acute Ischaemic Stroke (TRICS): protocol of multicentre, parallel group, randomised, preclinical trial in female and male rat and mouse from the Italian Stroke Organization (ISO) Basic Science network

Author

Tettamanti, M, Beretta, S, Pignataro, G, Fumagalli, S, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Valente, A, Diamanti, S, Mariani, J, Viganò, M, Santangelo, F, Zoia, C, Rogriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Gullotta, G, Bagetta, G, Martino, G, Ferrarese, C, De Simoni, M, Tettamanti, Mauro, Beretta, Simone, Pignataro, Giuseppe, Fumagalli, Stefano, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Valente, Alessia, Diamanti, Susanna, Mariani, Jacopo, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rogriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Gullotta, Giorgia Serena, Bagetta, Giacinto, Martino, Gianvito, Ferrarese, Carlo, De Simoni, Maria Grazia, Tettamanti, M, Beretta, S, Pignataro, G, Fumagalli, S, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Valente, A, Diamanti, S, Mariani, J, Viganò, M, Santangelo, F, Zoia, C, Rogriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Gullotta, G, Bagetta, G, Martino, G, Ferrarese, C, De Simoni, M, Tettamanti, Mauro, Beretta, Simone, Pignataro, Giuseppe, Fumagalli, Stefano, Perego, Carlo, Sironi, Luigi, Pedata, Felicita, Amantea, Diana, Bacigaluppi, Marco, Vinciguerra, Antonio, Valente, Alessia, Diamanti, Susanna, Mariani, Jacopo, Viganò, Martina, Santangelo, Francesco, Zoia, Chiara Paola, Rogriguez-Menendez, Virginia, Castiglioni, Laura, Rzemieniec, Joanna, Dettori, Ilaria, Bulli, Irene, Coppi, Elisabetta, Gullotta, Giorgia Serena, Bagetta, Giacinto, Martino, Gianvito, Ferrarese, Carlo, and De Simoni, Maria Grazia

Abstract

Introduction Multicentre preclinical randomised controlled trials (pRCT) are emerging as a necessary step to confirm efficacy and improve translation into the clinic. The aim of this project is to perform two multicentre pRCTs (one in rats and one in mice) to investigate the efficacy of remote ischaemic conditioning (RIC) in an experimental model of severe ischaemic stroke. Methods and analysis Seven research laboratories within the Italian Stroke Organization (ISO) Basic Science network will participate in the study. Transient endovascular occlusion of the proximal right middle cerebral artery will be performed in two species (rats and mice) and in both sexes. Animals will be randomised to receive RIC by transient surgical occlusion of the right femoral artery, or sham surgery, after reperfusion. Blinded outcome assessment will be performed for dichotomised functional neuroscore (primary endpoint) and infarct volume (secondary endpoint) at 48 hours. A sample size of 80 animals per species will yield 82% power to detect a significant difference of 30% in the primary outcome in both pRCTs. Analyses will be performed in a blind status and according to an intention-to-treat paradigm. The results of this study will provide robust, translationally oriented, high-quality evidence on the efficacy of RIC in multiple species of rodents with large ischaemic stroke. Ethics and dissemination This is approved by the Animal Welfare Regulatory Body of the University of Milano Bicocca, under project license from the Italian Ministry of Health. Trial results will be subject to publication according to the definition of the outcome presented in this protocol.

Published
2020

49. Residential Proximity to Attended Schools among Immigrant-Origin Youths in Bologna

Author

Santangelo F., Mantovani D., Gasperoni G., Abbruzzo A., Brentari E., Chiodi M. e Piacentino D., and Santangelo F. ,Mantovani D., Gasperoni G.

Subjects
Immigrant-origin student, Italy, education, Socio-economic status, Home-school proximity
Abstract

This paper explores home-school proximity among students attending lower secondary schools and identifies student and school characteristics associated with proximity differences. After having implemented a geolocation procedure to a data-base supplied by the Italian National Institute for the Evaluation of the Educational System for Schooling and Training (INVALSI), distances between students’ homes, their schools and other schools are examined for evidence of differences between native- and immigrant-origin students.

Published
2018

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