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2. Toxicity and Teratogenic Potential of Piplartine from Piper tuberculatum Jacq. during Embryonic Development in Mice (Mus musculus).

Author

Silva, Giulliano Rezende, Miranda, Lívia Thaís Gontijo, da Silva, Shirley Aline da Costa Arteaga, Andrade, Laise Rodrigues de, Souza, Natanael Carvalho de, Sá, Bruno Silva, Santana, Elivaldo Ribeiro de, Vasconcelos, Andreanne Gomes, Moreira, Daniel Carneiro, Pic-Taylor, Aline, Durazzo, Alessandra, Lucarini, Massimo, Yamaguchi, Lydia Fumiko, Kato, Massuo Jorge, Damazo, Amilcar Sabino, Arcanjo, Daniel Dias Rufino, Leite, José Roberto de Souza de Almeida, and Baroneza, José Eduardo

Subjects
EMBRYOLOGY, MICE, ORAL drug administration, FETAL abnormalities, BONE marrow cells
Abstract

Piplartine, also known as piperlongumine, is a natural and biologically active amide alkaloid found in various Piper species within the Piperaceae family. It possesses numerous beneficial properties that can be leveraged in the development of nanotechnological and pharmaceutical products. However, information on the effects of piplartine on mammalian embryonic development is scarce. This study aims to assess the general toxicity and teratogenic potential of piplartine during the embryonic development of mice. Pregnant mice received daily treatments of 25, 50, or 100 mg/kg of piplartine via gavage from the sixth day of gestation (implantation) to the eighteenth. On the eighteenth day, the mice were euthanized, and whole organs, blood samples (for hematological and biochemical analyses), and bone marrow cells (for DNA fragmentation and cell cycle assays) were collected. The uterus was examined for implantation sites and embryo resorptions. Additionally, fetuses were collected to assess for fetal anomalies. Piplartine did not result in maternal or embryo-fetal toxicity, induce fetal anomalies, cause hematological and biochemical alterations, or lead to DNA fragmentation. The oral administration of piplartine is safe and does not exhibit toxicity or teratogenic effects in mice. This finding opens avenues for the development of piplartine-based biotechnological products for therapeutic interventions in disease treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Sustentabilidade e Responsabilidade Social em Foco-Volume 14

Author

Lerman, Laura Visintainer, primary, Sander, Natália Eloísa, additional, Uhr, Raquel de Abreu Pereira, additional, Januário, Thays Lorranny da Silva, additional, Marinho, Jefferson Luiz Alves, additional, Oliveira, Janeide Ferreira Alencar de, additional, Santos, Adna Amorim dos, additional, Queiroz, Lucas Marcos Silva, additional, Sanjulião, Lo-Ruana Karen Amorim Freire, additional, Rodrigues, Thales Volpe, additional, Fernandes, Carlos Henrique, additional, Reis, Maria José, additional, Farias, Adriana Salete Dantas de, additional, Veloso, Renata Cristina A. de Mendonça, additional, Silva Filho, José Ribamar Tomaz da, additional, Silva, Rosângela Sarmento, additional, Silva, Tony Stevão Alves da, additional, Resende, Caroline Alves, additional, Josué, Tatiana Gulminie, additional, Almeida, Lariana Negrão Beraldo de, additional, Nascimento, Mariana dos Santos do, additional, Spanhol, André, additional, Macêdo, Francisca Francivânia R. R., additional, Freire, Maria Maciléya Azevedo, additional, Albuquerque Filho, Antônio Rodrigues, additional, Andrade, Fabiana Rodrigues Barboza de, additional, Veiga, Lilian Bechara Elabras, additional, Castro, Jefferson Pereira da Silva, additional, Benedicto, Samuel Carvalho De, additional, Rocha, Mônica de Oliveira, additional, Sugahara, Cibele Roberta, additional, Cantarelli V. Ferreira Cantarelli, Eduardo, additional, Santos, Fabio Medeiros dos, additional, Carvalho, Gabriele Cristine Bernardo de, additional, Dantes, Luan de Carvalho, additional, Sotero, Camila da Silva, additional, Mascarenhas, Paulo Sérgio Monteiro, additional, Lemos, Odair Lacerda, additional, Biscola, Ionara dos Santos, additional, Mallmann, Viviane, additional, Aragão, Lucas Wagner Ribeiro, additional, Fernandes, Shaline Séfara Lopes, additional, Fernandes, Tauane Catilza Lopes, additional, Adrião, Maria Antônia Veiga, additional, Feitosa, Antônia Arisdélia F. Matias Aguiar, additional, Andrade, Maria Neide Moura Martins de, additional, França, Dayana Priscyla da Silva, additional, Santana, Elivaldo Ribeiro de, additional, Abreu, Lucimar Santiago de, additional, Bellon, Stéphane, additional, Torres, Tercia Zavaglia, additional, Lima, Tânia Olinda, additional, Freitas, Clodoaldo de Oliveira, additional, Leite, Eliane Silva, additional, Oliveira, Bruna Érica de, additional, Töpke, Denise Rugani, additional, López, Mariana Pires Vidal, additional, Fernandes, Maria Célia, additional, Justino, Ana Neri da Paz, additional, Silva, Jurema Márcia Dantas da, additional, Dutra, Jurandir Moura, additional, Dutra, Marcelo José de Lima, additional, Menezes, Samara Barbosa de, additional, and Oliveira, Josildo Severino de, additional

Published
2019
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5. Sustentabilidade e Responsabilidade Social em Foco-Volume 14

Author

Lerman, Laura Visintainer, Sander, Natália Eloísa, Uhr, Raquel de Abreu Pereira, Januário, Thays Lorranny da Silva, Marinho, Jefferson Luiz Alves, Oliveira, Janeide Ferreira Alencar de, Santos, Adna Amorim dos, Queiroz, Lucas Marcos Silva, Sanjulião, Lo-Ruana Karen Amorim Freire, Rodrigues, Thales Volpe, Fernandes, Carlos Henrique, Reis, Maria José, Farias, Adriana Salete Dantas de, Veloso, Renata Cristina A. de Mendonça, Silva Filho, José Ribamar Tomaz da, Silva, Rosângela Sarmento, Silva, Tony Stevão Alves da, Resende, Caroline Alves, Josué, Tatiana Gulminie, Almeida, Lariana Negrão Beraldo de, Nascimento, Mariana dos Santos do, Spanhol, André, Macêdo, Francisca Francivânia R. R., Freire, Maria Maciléya Azevedo, Albuquerque Filho, Antônio Rodrigues, Andrade, Fabiana Rodrigues Barboza de, Veiga, Lilian Bechara Elabras, Castro, Jefferson Pereira da Silva, Benedicto, Samuel Carvalho De, Rocha, Mônica de Oliveira, Sugahara, Cibele Roberta, Cantarelli V. Ferreira Cantarelli, Eduardo, Santos, Fabio Medeiros dos, Carvalho, Gabriele Cristine Bernardo de, Dantes, Luan de Carvalho, Sotero, Camila da Silva, Mascarenhas, Paulo Sérgio Monteiro, Lemos, Odair Lacerda, Biscola, Ionara dos Santos, Mallmann, Viviane, Aragão, Lucas Wagner Ribeiro, Fernandes, Shaline Séfara Lopes, Fernandes, Tauane Catilza Lopes, Adrião, Maria Antônia Veiga, Feitosa, Antônia Arisdélia F. Matias Aguiar, Andrade, Maria Neide Moura Martins de, França, Dayana Priscyla da Silva, Santana, Elivaldo Ribeiro de, Abreu, Lucimar Santiago De, Bellon, Stéphane, Torres, Tercia Zavaglia, Lima, Tânia Olinda, Freitas, Clodoaldo de Oliveira, Leite, Eliane Silva, Oliveira, Bruna Érica de, Töpke, Denise Rugani, López, Mariana Pires Vidal, Fernandes, Maria Célia, Justino, Ana Neri da Paz, Silva, Jurema Márcia Dantas da, Dutra, Jurandir Moura, Dutra, Marcelo José de Lima, Menezes, Samara Barbosa de, Oliveira, Josildo Severino de, EMBRAPA Meio Ambiente, Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de la Recherche Agronomique (INRA), EMBRAPA INFORMATICA CAMPINAS BRA, Partenaires IRSTEA, and Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)

Subjects
ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2019
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