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8 results on '"Santana, Cinthia Vila Nova"'

1. Predictive genetic panel for adult asthma using machine learning methods

Author

Gomes, Luciano Gama da Silva, Cruz, Álvaro Augusto Souza da, de Santana, Maria Borges Rabêlo, Pinheiro, Gabriela Pimentel, Santana, Cinthia Vila Nova, Santos, Carolina Barbosa Souza, Boorgula, Meher Preethi, Campbell, Monica, Machado, Adelmir de Souza, Veiga, Rafael Valente, Barnes, Kathleen C., Costa, Ryan dos Santos, and Figueiredo, Camila Alexandrina

Published
2024
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3. Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of Extreme Obesity.

Author

Santana, Cinthia Vila Nova, Magno, Luiz Alexandre Viana, Ramos, Adauto Versiani, Rios, Maria Angélica, Sandrim, Valéria Cristina, De Marco, Luiz Armando, Miranda, Débora Marques de, Romano-Silva, Marco Aurélio, and Stocker, Claire

Subjects
*OBESITY risk factors, *PROTEIN precursors, *RISK assessment, *RESEARCH funding, *AMP-activated protein kinases, *TRANSCRIPTION factors, *GENETIC variation, *ODDS ratio, *FOOD habits, *CONFIDENCE intervals, *WEIGHT gain
Abstract

Objective: Genetic variability significantly impacts metabolism, weight gain, and feeding behaviors, predisposing individuals to obesity. This study explored how variations in key genes related to obesity—FOXO3A (forkhead box O3), AMPK (protein kinase AMP‐activated), and POMC (proopiomelanocortin)—are associated with extreme obesity (EOB). Methods: We conducted a case–control study with 251 EOB patients and 212 healthy controls with a body mass index (BMI) of less than 25 kg/m2. We genotyped 10 single nucleotide variants (SNVs) using TaqMan‐based assays. Results: Four SNVs—rs1536057 in FOXO3A, rs103685 in AMPK, rs934778, and rs6545975 in POMC—were associated with an increased risk of EOB. The strongest association was observed with rs934778 (POMC), which had a maximum odds ratio (OR) of 5.26 (95% CI: 2.86–9.09). While these genetic variations are closely linked to EOB, they do not affect serum glucose, triglycerides, HDL, LDL, BMI, or waist circumference. Conclusions: These findings indicate that factors beyond traditional metabolic pathways, potentially related to feeding behavior or hormonal regulation, may also link these genetic variations to obesity. Further research in a larger sample is essential to validate these findings and explore their potential to guide clinical interventions and public health strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Variants in interferon gamma inducible protein 16 (IFI16) and absent in melanoma 2 (AIM2) genes that modulate inflammatory response are associated with periodontitis

Author

Barrientos, Marcia Otto, primary, Cruz, Álvaro A., additional, Teixeira, Helena M.P., additional, Silva, Hátilla dos Santos, additional, Gomes-Filho, Isaac Suzart, additional, Trindade, Soraya Castro, additional, Soledade, Kaliane Rocha, additional, Fernandes, Jamille Souza, additional, Santana, Cinthia Vila Nova, additional, Pinheiro, Gabriela Pimentel, additional, Souza-Machado, Adelmir, additional, Costa, Ryan dos Santos, additional, Figueiredo, Camila A., additional, and Oliveira, Tatiane Teixeira Muniz Carletto, additional

Published
2023
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7. Blood cytokines in atopic and non‐atopic eosinophilic moderate to severe asthmatics

Author

Fernandes, Jamille Souza, primary, Cardoso, Luciana Santos, additional, Carneiro, Norma Vilany Queiroz, additional, das Chagas, Gabriela Pimentel Pinheiro, additional, Santana, Cinthia Vila Nova, additional, Atta, Ajax M., additional, de Oliveira, Isabela Silva, additional, Carvalho, Edgar M., additional, Figueiredo, Camila Alexandrina, additional, and Cruz, Álvaro A., additional

Published
2022
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8. Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects

Author

Johnson, Randi K., primary, Manke, Jonathan, additional, Campbell, Monica, additional, Armstrong, Michael, additional, Boorgula, Meher Preethi, additional, Pinheiro, Gabriela, additional, Santana, Cinthia Vila Nova, additional, Mathias, Rasika A., additional, Barnes, Kathleen C., additional, Cruz, Alvaro, additional, Reisdorph, Nichole, additional, and Figueiredo, Camila A., additional

Published
2022
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