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4. A New SERPINA-1 Missense Mutation Associated with Alpha-1 Antitrypsin Deficiency and Bronchiectasis

Author

Carpagnano, G. E., Santacroce, R., Palmiotti, G. A., Leccese, A., Giuffreda, E., Margaglione, M., and Foschino Barbaro, M. P.

Subjects
Alpha 1-antitrypsin deficiency -- Research, Gene mutation -- Research, Bronchiectasis -- Genetic aspects -- Research, Health
Abstract

Alpha-1-antitrypsin deficiency (AATD) is a genetic condition caused by SERPINA1 mutations, which culminates into lower protease inhibitor activity in the serum and predisposes to emphysema. Clinical manifestations of AATD are often associated to ZZ (p.Glu342Lys) and SZ (p.Glu264Val) genotypes and less frequently to rare deficiency or null alleles in heterozygous and homozygous states. We report a case of a 52-year-old woman with bronchiectasis without other potential causes other than an electrophoresis that showed a decrease of alpha-1 globin band and AAT levels below the normal value (78 mg/dl; v.n. 90-200 mg/dl). No S or Z mutation was identified, but sequencing analysis found a novel missense variant Ile74Asn (c.221T > A) in heterozygous state on an M3 allele (Glu400Asp) in the exon 2 of the SERPINA-1gene, probably leading to a dysfunctional protein. This mutation has never been previously identified, and it is interesting to note the association with bronchiectasis in the absence of emphysema., Author(s): G. E. Carpagnano [sup.1] , R. Santacroce [sup.2] , G. A. Palmiotti [sup.1] , A. Leccese [sup.2] , E. Giuffreda [sup.1] , M. Margaglione [sup.2] , M. P. Foschino [...]

Published
2017
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10. Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis

Author

Ken-Dror, G, Cotlarciuc, I, Martinelli, I, Grandone, E, Hiltunen, S, Lindgren, E, Margaglione, M, Duchez, VLC, Triquenot, AB, Zedde, M, Mancuso, M, Ruigrok, YM, Marjot, T, Worrall, B, Majersik, JJ, Metso, TM, Putaala, J, Haapaniemi, E, Zuurbier, SM, Brouwer, MC, Passamonti, SM, Abbattista, M, Bucciarelli, P, Mitchell, BD, Kittner, SJ, Lemmens, R, Jern, C, Pappalardo, E, Costa, P, Colombi, M, de Sousa, DA, Rodrigues, S, Canhao, P, Tkach, A, Santacroce, R, Favuzzi, G, Arauz, A, Colaizzo, D, Spengos, K, Hodge, A, Ditta, R, Pezzini, A, Debette, S, Coutinho, JM, Thijs, V, Jood, K, Pare, G, Tatlisumak, T, Ferro, JM, Sharma, P, Ken-Dror, G, Cotlarciuc, I, Martinelli, I, Grandone, E, Hiltunen, S, Lindgren, E, Margaglione, M, Duchez, VLC, Triquenot, AB, Zedde, M, Mancuso, M, Ruigrok, YM, Marjot, T, Worrall, B, Majersik, JJ, Metso, TM, Putaala, J, Haapaniemi, E, Zuurbier, SM, Brouwer, MC, Passamonti, SM, Abbattista, M, Bucciarelli, P, Mitchell, BD, Kittner, SJ, Lemmens, R, Jern, C, Pappalardo, E, Costa, P, Colombi, M, de Sousa, DA, Rodrigues, S, Canhao, P, Tkach, A, Santacroce, R, Favuzzi, G, Arauz, A, Colaizzo, D, Spengos, K, Hodge, A, Ditta, R, Pezzini, A, Debette, S, Coutinho, JM, Thijs, V, Jood, K, Pare, G, Tatlisumak, T, Ferro, JM, and Sharma, P

Abstract

OBJECTIVE: Cerebral venous thrombosis (CVT) is an uncommon form of stroke affecting mostly young individuals. Although genetic factors are thought to play a role in this cerebrovascular condition, its genetic etiology is not well understood. METHODS: A genome-wide association study was performed to identify genetic variants influencing susceptibility to CVT. A 2-stage genome-wide study was undertaken in 882 Europeans diagnosed with CVT and 1,205 ethnicity-matched control subjects divided into discovery and independent replication datasets. RESULTS: In the overall case-control cohort, we identified highly significant associations with 37 single nucleotide polymorphisms (SNPs) within the 9q34.2 region. The strongest association was with rs8176645 (combined p = 9.15 × 10-24 ; odds ratio [OR] = 2.01, 95% confidence interval [CI] = 1.76-2.31). The discovery set findings were validated across an independent European cohort. Genetic risk score for this 9q34.2 region increases CVT risk by a pooled estimate OR = 2.65 (95% CI = 2.21-3.20, p = 2.00 × 10-16 ). SNPs within this region were in strong linkage disequilibrium (LD) with coding regions of the ABO gene. The ABO blood group was determined using allele combination of SNPs rs8176746 and rs8176645. Blood groups A, B, or AB, were at 2.85 times (95% CI = 2.32-3.52, p = 2.00 × 10-16 ) increased risk of CVT compared with individuals with blood group O. INTERPRETATION: We present the first chromosomal region to robustly associate with a genetic susceptibility to CVT. This region more than doubles the likelihood of CVT, a risk greater than any previously identified thrombophilia genetic risk marker. That the identified variant is in strong LD with the coding region of the ABO gene with differences in blood group prevalence provides important new insights into the pathophysiology of CVT. ANN NEUROL 2021;90:777-788.

Published
2021

17. Probing the Vesuvius magma chamber--host rock interface through xenoliths

Author

Fulignati, P., Marianelli, P., Santacroce, R., and Sbrana, A.

Subjects
Volcanoes -- Research, Earth sciences
Abstract

The thermal and compositional conditions of magma chambers constrain the type and complexity of their metasomatic aureoles. Fragments of these aureoles, disrupted during explosive eruptions of Vesuvius, provide quenched snapshots of interactions between potassic magmas and carbonate country rocks. Near the highly crystallized peripheral portions of the chambers, represented by magmatic xenoliths (fergusites, syenites and pyroxenites), skarn aureoles form. Open conduit reservoirs and the lower portions of plinian and subplinian eruption magma chambers develop aureoles controlled by diffusive metasomatism by high-T-modified silicate melts, generating magmatic skarn. In contrast, infiltrative metasomatism by magmatic fluids exsolved from crystallizing margins is responsible for endoskarn (magmatic protolith) and exoskarn (carbonate protolith) formation in the upper portions of plinian and subplinian eruption magma chambers. Keywords: Vesuvius, magma chamber, skarn, melt inclusions, fluid inclusions.

Published
2004

23. May 5, 1998, debris flows in circum-Vesuvian areas (southern Italy): insights for hazard assessment

Author

Pareschi, M.T., Favalli, M., Giannini, F., Sulpizio, R., Zanchetta, G., and Santacroce, R.

Subjects
Vesuvius -- Natural history, Hazardous geographic environments -- Research, Volcanoes -- Research, Earth sciences
Abstract

Data from the May 5, 1998 debris flow from the alluvial-fan deposits east of the Vesuvius volcano has been used to develop a model to evaluate the hazard potential of similar flows for the nearby Clanio Valley. Air-fall deposits have the potential for hazards that remain decades or centuries after a volcanic eruption.

Published
2000

26. Familial aggregation of MATRICS Consensus Cognitive Battery scores in a large sample o outpatients with schizophrenia and their unaffected relatives

Author

Mucci A., Galderisi S., Green M. F., Nuechterlein K., Rucci P., Gibertoni D., Rossi A., Rocca P., Bertolino A., Bucci P., Hellemann G., Spisto M., Palumbo D., Aguglia E., Amodeo G., Amore M., Bellomo A., Brugnoli R., Carpiniello B., Dell'osso L., Di Fabio F., Di Giannantonio M., Di Lorenzo G., Marchesi C., Monteleone P., Montemagni C., Oldani L., Romano R., Roncone R., Stratta P., Tenconi E., Vita A., Zeppegno P., Maj M., Piegari G., Vignapiano A., Caputo F., Plescia G., Montefusco V., Mancini M., Attrotto M. T., Paladini V., Atti A. R., Barlati S., Galluzzo A., Mussoni C., Pinna F., Sanna L., Primavera D., Signorelli M. S., Minutolo G., Cannavo D., Acciavatti T., Santacroce R., Corbo M., Altamura M., La Montagna M., Carnevale R., Pizziconi G., Rossi R., Santarelli V., Giusti L., Malavolta M., Salza A., Murri M. B., Calcagno P., Bugliani M., Serati M., Orsenigo G., Gramaglia C., Gattoni E., Cattaneo C., Campagnola N., Ferronato L., Piovan C., Tonna M., Bettini E., Ossola P., Gesi C., Landi P., Rutigliano G., Biondi M., Girardi P., Buzzanca A., Zocconali M., Comparelli A., Mancinelli I., Niolu C., Ribolsi M., Siracusano A., Corrivetti G., Bartoli L., Diasco F., Bolognesi S., Goracci A., Fagiolini A., Bellino S., Cardillo S., Bracale N., Mucci, A., Galderisi, S., Green, M. F., Nuechterlein, K., Rucci, P., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Bucci, P., Hellemann, G., Spisto, M., Palumbo, D., Aguglia, E., Amodeo, G., Amore, M., Bellomo, A., Brugnoli, R., Carpiniello, B., Dell'Osso, L., Di Fabio, F., Di Giannantonio, M., Di Lorenzo, G., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Romano, R., Roncone, R., Stratta, P., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Piegari, G., Vignapiano, A., Caputo, F., Plescia, G., Montefusco, V., Mancini, M., Attrotto, M. T., Paladini, V., Atti, A. R., Barlati, S., Galluzzo, A., Mussoni, C., Pinna, F., Sanna, L., Primavera, D., Signorelli, M. S., Minutolo, G., Cannavo, D., Acciavatti, T., Santacroce, R., Corbo, M., Altamura, M., La Montagna, M., Carnevale, R., Pizziconi, G., Rossi, R., Santarelli, V., Giusti, L., Malavolta, M., Salza, A., Murri, M. B., Calcagno, P., Bugliani, M., Serati, M., Orsenigo, G., Gramaglia, C., Gattoni, E., Cattaneo, C., Campagnola, N., Ferronato, L., Piovan, C., Tonna, M., Bettini, E., Ossola, P., Gesi, C., Landi, P., Rutigliano, G., Biondi, M., Girardi, P., Buzzanca, A., Zocconali, M., Comparelli, A., Mancinelli, I., Niolu, C., Ribolsi, M., Siracusano, A., Corrivetti, G., Bartoli, L., Diasco, F., Bolognesi, S., Goracci, A., Fagiolini, A., Bellino, S., Cardillo, S., Bracale, N., and di Giannantonio, M.

Subjects
Attention, MCCB Italian standardization, reasoning and problem solving, social cognition, verbal learning, working memory, Proband, Adult, Male, Consensus, Psychometrics, Context (language use), social cognition, Verbal learning, working memory, 03 medical and health sciences, Attention, MCCB Italian standardization, reasoning and problem solving, verbal learning, Aged, Cognition, Cognitive Dysfunction, Family, Female, Humans, Middle Aged, Outpatients, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, 0302 clinical medicine, Social cognition, medicine, Applied Psychology, Psychiatry and Mental Health, Family aggregation, medicine.disease, 030227 psychiatry, Settore MED/25, Psychology, MATRICS, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology
Abstract

BackgroundThe increased use of the MATRICS Consensus Cognitive Battery (MCCB) to investigate cognitive dysfunctions in schizophrenia fostered interest in its sensitivity in the context of family studies. As various measures of the same cognitive domains may have different power to distinguish between unaffected relatives of patients and controls, the relative sensitivity of MCCB tests for relative–control differences has to be established. We compared MCCB scores of 852 outpatients with schizophrenia (SCZ) with those of 342 unaffected relatives (REL) and a normative Italian sample of 774 healthy subjects (HCS). We examined familial aggregation of cognitive impairment by investigating within-family prediction of MCCB scores based on probands’ scores.MethodsMultivariate analysis of variance was used to analyze group differences in adjusted MCCB scores. Weighted least-squares analysis was used to investigate whether probands’ MCCB scores predicted REL neurocognitive performance.ResultsSCZ were significantly impaired on all MCCB domains. REL had intermediate scores between SCZ and HCS, showing a similar pattern of impairment, except for social cognition. Proband's scores significantly predicted REL MCCB scores on all domains except for visual learning.ConclusionsIn a large sample of stable patients with schizophrenia, living in the community, and in their unaffected relatives, MCCB demonstrated sensitivity to cognitive deficits in both groups. Our findings of significant within-family prediction of MCCB scores might reflect disease-related genetic or environmental factors.

Published
2018

32. The emergence of Exercise Addiction, Body Dysmorphic Disorder, and other image-related psychopathological correlates in fitness settings: A cross sectional study

Author

Corazza, O, Simonato, P, Demetrovics, Z, Mooney, R, van de Ven, K, Roman-Urrestarazu, A, Rácmolnár, L, De Luca, I, Cinosi, E, Santacroce, R, Marini, M, Wellsted, D, Sullivan, K, Bersani, G, Martinotti, G, Corazza, O, Simonato, P, Demetrovics, Z, Mooney, R, van de Ven, K, Roman-Urrestarazu, A, Rácmolnár, L, De Luca, I, Cinosi, E, Santacroce, R, Marini, M, Wellsted, D, Sullivan, K, Bersani, G, and Martinotti, G

Abstract

Introduction In a society that perpetuates the strive for a perfect appearance, a fit body has become synonymous with success, but simultaneously hard to achieve. This represents a fertile ground for the development of Exercise Addiction (EA) alongside other disorders, such as Body Dysmorphic Disorder (BDD). This study aims to explore the diffusion of EA in fitness settings in the United Kingdom, Italy, Netherlands, Hungary and the previously unexplored association with appearance anxiety, BDD, self-esteem and the use of fitness supplements. Methods A large cross-sectional sample (N = 1711) was surveyed in fitness settings using the Exercise Addiction Inventory (EAI), Appearance Anxiety Inventory (AAI) and Rosenberg’s Self Esteem Scale (RSE) in addition to questions surrounding the use of fitness supplements. Results Compulsive exercise, appearance anxiety and low self-esteem were present in this sample according to the psychometric measures used (EAI, AAI, RSE). 11.7% scored over the cut off for EA, with alarming peaks in the Netherlands (20.9%) and the United Kingdom (16.1%). 38.5% were found at risk of BDD, mainly female (47.2%). 39.8% used fitness enhancing supplements without medical consultation (95.5%). This cohort of supplement users scored higher in both EAI and AAI. The logistic regression model revealed a strong association between the consumption of sport products and the level of EA across the sample with an odds ratio (OR) of 3.03. Other co-variable factors among female were appearance anxiety (AAI; OR 1.59) and to a lesser extent self-esteem (RSE) (OR 1.08). Conclusions This study identified a high risk of EA, appearance anxiety and BDD amongst a cohort of gym users internationally. The previously-unexplored association between these disorders and the unsupervised use of a variety of fitness products, including illicit drugs, highlights the need for informed and integrated responses targeting such vulnerable individuals.

Published
2019

37. Substance-related psychopathology and aggressiveness in a nightlife holiday resort: Results from a pilot study in a psychiatric inpatient unit in Ibiza

Author

Martinotti, Giovanni, Cinosi, E., Santacroce, Rita, Papanti, D., Pasquini, Annalisa, Mancini, V., Corbo, M., Fiori, F., Sarchione, F., Marchetti, D., Verrocchio, M. C., Di Giannantonio, Massimo, Torrens, M., Schifano, F., Morlan Coarasa, M. J., Merino del Villar, C., Martinotti G., Santacroce R., Pasquini A., Di Giannantonio M., Martinotti, Giovanni, Cinosi, E., Santacroce, Rita, Papanti, D., Pasquini, Annalisa, Mancini, V., Corbo, M., Fiori, F., Sarchione, F., Marchetti, D., Verrocchio, M. C., Di Giannantonio, Massimo, Torrens, M., Schifano, F., Morlan Coarasa, M. J., Merino del Villar, C., Martinotti G., Santacroce R., Pasquini A., and Di Giannantonio M.

Abstract

Objectives: We aimed to describe a sample of subjects admitted to a psychiatric unit after the intake of psychoactive substances for recreational purposes. Methods: Between June and September 2015, 49 subjects were included. Sociodemographic characteristics and psychopathological aspects were investigated, and urine samples for further analysis were collected. Three subgroups (cannabinoids, stimulants, and depressors users) were identified, according to the structured interview regarding substance use and urinalysis. Results: Level of aggressiveness was found to be significantly higher (p <.05) in the cannabinoids subgroup. Self-reported symptom severity was comparable among groups, but trends could be identified: SCL-90 results showed a prevalence of anxiety symptoms among depressors users, hostility or aggression in the tetrahydrocannabinol subgroup, and psychoticism in the stimulants subgroup. Conclusions: The use of psychoactive substances was be characterised by poly-use of both traditional and novel substances. The presence of aggressiveness emerged as a main feature associated with the use of cannabis and other cannabinoids. Binge drinking and sleep deprivation also represented a relevant component in almost all the evaluated subjects.

Published
2017

40. A comprehensive overview on Kratom

Author

Cinosi, E., Simonato, P., Singh, D., Bersani, F. S., Piazzon, G., Lupi, M., Marini, S., Kapitány-Fövény, M., Farkas, J., Demetrovics, Z., Roman-Urrestarazu, A., Vicknasingam, B., J. H., Li, W. J., Yu, Santacroce, R., Acciavatti, T., Martinotti, G., Di Giannantonio, M., and Corazza, O.

Subjects
kratom, addiction
Published
2016

41. Identification of FVIII gene mutations in patients with hemophilia A using new combinatorial sequencing by hybridization

Author

Chetta, M., Drmanac, A., Santacroce, R., Grandone, E., Surrey, S., Fortina, P., and Margaglione, M.

Subjects
Gene mutations -- Analysis -- Usage -- Genetic aspects, Nucleotide sequence -- Analysis -- Genetic aspects -- Usage, Hemophilia -- Care and treatment -- Genetic aspects, Blood coagulation factor VIII -- Analysis -- Genetic aspects -- Usage, Polymerase chain reaction -- Usage -- Analysis -- Genetic aspects, Health, Science and technology, Care and treatment, Analysis, Usage, Genetic aspects
Abstract

Byline: M. Chetta, A. Drmanac, R. Santacroce, E. Grandone, S. Surrey, P. Fortina, M. Margaglione Background: Standard methods of mutation detection are time consuming in Hemophilia A (HA) rendering their [...]

Published
2008

42. Mapping the tephra fallout risk: an example from Vesuvius, Italy

Author

Barberi, F., Macedonio, G., Pareschi, M.T., and Santacroce, R.

Subjects
Volcanic ash, tuff, etc. -- Forecasts and trends, Volcanic activity prediction -- Models, Environmental issues, Science and technology, Zoology and wildlife conservation
Published
1990

44. Party Hard: Drug-related Fatalities in Ibiza from 2010 to 2016

Author

Santacroce, R., primary, Bennasar, C. Ruiz, additional, Jaraiz, J.R. Sancho, additional, Montemitro, C., additional, Baroni, G., additional, Corbo, M., additional, Pasquini, A., additional, Sarchione, F., additional, Angelini, F., additional, Catalano, G., additional, Carenti, M.L., additional, Di Taranto, C., additional, Tenuta, S., additional, Lecciso, U., additional, De Angelis, M., additional, Rondoni, A., additional, Di Giannantonio, M., additional, and Martinotti, G., additional

Published
2017
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45. Role of Co-occurring Alcohol and Substances Abuse on QTc Interval Prolongation Among Psychiatric Patients: A Cross-sectional National Survey

Author

Corbo, M., primary, Acciavatti, T., additional, Fiori, F., additional, Santacroce, R., additional, Aguglia, A., additional, Bartoli, F., additional, Calò, S., additional, Ribolsi, M., additional, Barone, Y., additional, Pinna, F., additional, Stilo, M., additional, Staffa, P., additional, Caroleo, M., additional, Ruberto, S., additional, Signorelli, M.S., additional, Suraniti, F., additional, Quattrone, D., additional, Reggianini, C., additional, Carra, E., additional, Gazzoletti, E., additional, Campese, O., additional, Castellazzi, M., additional, Ostuzzi, G., additional, Bighelli, I., additional, Nosè, M., additional, Barbui, C., additional, and Martinotti, G., additional

Published
2017
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49. Cannabis: a self-medication drug for weight management? The never ending story

Author

Bersani, FRANCESCO SAVERIO, Santacroce, R, Coviello, M, Imperatori, C, Francesconi, Marta, Vicinanza, Roberto, Minichino, Amedeo, and Corazza, O.

Subjects
cannabis, image enhancing drugs, weight loss, Marijuana Abuse, Cannabinoids, Illicit Drugs, Weight Loss, Body Image, Humans, Anti-Obesity Agents, Self Medication, Cannabis
Abstract

In a society highly focused on physical appearance, people are increasingly using the so-called performance and image-enhancing drugs (PIEDs) or life-style drugs as an easy way to control weight. Preliminary data from online sources (e.g. websites, drug forums, e-newsletters) suggest an increased use of cannabis amongst the general population as a PIED due to its putative weight-loss properties. The use of cannabis and/or cannabis-related products to lose weight may represent a new substance-use trend that should be carefully monitored and adequately investigated, especially in light of the well-known adverse psychiatric and somatic effects of cannabis, its possible interaction with other medications/drugs and the unknown and potentially dangerous composition of synthetic cannabimimetics preparations.

Published
2015

50. Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol

Author

Cotlarciuc, I, Marjot, T, Khan, MS, Hiltunen, S, Haapaniemi, E, Metso, TM, Putaala, J, Zuurbier, SM, Brouwer, MC, Passamonti, SM, Bucciarelli, P, Pappalardo, E, Patel, T, Costa, P, Colombi, M, Canhao, P, Tkach, A, Santacroce, R, Margaglione, M, Favuzzi, G, Grandone, E, Colaizzo, D, Spengos, K, Arauz, A, Hodge, A, Ditta, R, Debette, S, Zedde, M, Pare, G, Ferro, JM, Thijs, V, Pezzini, A, Majersik, JJ, Martinelli, I, Coutinho, JM, Tatlisumak, T, Sharma, P, Cotlarciuc, I, Marjot, T, Khan, MS, Hiltunen, S, Haapaniemi, E, Metso, TM, Putaala, J, Zuurbier, SM, Brouwer, MC, Passamonti, SM, Bucciarelli, P, Pappalardo, E, Patel, T, Costa, P, Colombi, M, Canhao, P, Tkach, A, Santacroce, R, Margaglione, M, Favuzzi, G, Grandone, E, Colaizzo, D, Spengos, K, Arauz, A, Hodge, A, Ditta, R, Debette, S, Zedde, M, Pare, G, Ferro, JM, Thijs, V, Pezzini, A, Majersik, JJ, Martinelli, I, Coutinho, JM, Tatlisumak, T, and Sharma, P

Abstract

INTRODUCTION: Cerebral venous thrombosis (CVT) is a rare cerebrovascular condition accounting for <1% of all stroke cases and mainly affects young adults. Its genetic aetiology is not clearly elucidated. METHODS AND ANALYSIS: To better understand the genetic basis of CVT, we have established an international biobank of CVT cases, Biorepository to Establish the Aetiology of Sinovenous Thrombosis (BEAST) which aims to recruit highly phenotyped cases initially of European descent and later from other populations. To date we have recruited 745 CVT cases from 12 research centres. As an initial step, the consortium plans to undertake a genome-wide association analysis of CVT using the Illumina Infinium HumanCoreExome BeadChip to assess the association and impact of common and low-frequency genetic variants on CVT risk by using a case-control study design. Replication will be performed to confirm putative findings. Furthermore, we aim to identify interactions of genetic variants with several environmental and comorbidity factors which will likely contribute to improve the understanding of the biological mechanisms underlying this complex disease. ETHICS AND DISSEMINATION: BEAST meets all ethical standards set by local institutional review boards for each of the participating sites. The research outcomes will be published in international peer-reviewed open-access journals with high impact and visibility. The results will be presented at national and international meetings to highlight the contributions into improving the understanding of the mechanisms underlying this uncommon but important disease. This international DNA repository will become an important resource for investigators in the field of haematological and vascular disorders.

Published
2016

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