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2. UnTWISTing intestinal fibrosis: single-cell transcriptomics deciphers fibroblast heterogeneity, uncovers molecular pathways, and identifies therapeutic targets

Author

Santacroce, Giovanni and Di Sabatino, Antonio

Subjects
Medical research, Medicine, Experimental, Fibrosis -- Physiological aspects -- Care and treatment -- Genetic aspects, Colorectal diseases -- Physiological aspects -- Care and treatment -- Genetic aspects, RNA sequencing -- Usage, Fibroblasts -- Health aspects, Gastrointestinal diseases -- Physiological aspects -- Care and treatment -- Genetic aspects, Transcription factors -- Health aspects -- Genetic aspects
Abstract

Intestinal fibrosis is a severe complication of Crohn's disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process. They identified a key fibroblast subset of TWISTV[FAP.sup.+] cells that interacts with [CXCL9.sup.+] macrophages. TWIST1 emerged as a central regulator of the fibrotic microenvironment, representing a promising therapeutic target for effectively treating intestinal fibrosis., Intestinal fibrosis and single-cell transcriptomics Intestinal fibrosis is a common complication of Crohn's disease (CD), and it leads to strictures and obstructive symptoms (1). It affects more than 50% of [...]

Published
2024
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4. Follow-up evaluation and management of anemia in inflammatory bowel disease: A study by the Italian Group for Inflammatory Bowel Diseases (IG-IBD)

Author

Amodeo, Giuseppe, Antonelli, Elisabetta, Bertetti, Noemi, Bezzio, Cristina, Campigotto, Michele, Caccaro, Roberta, De Bona, Manuela, Della Corte, Cristina, Demarzo, Maria G., Falasco, Giuliano, Fontana, Rosanna, Gionchetti, Paolo, Iovino, Paola, Lepore, Federica, Lorenzon, Greta, Marasco, Veronica, Paolini, Alessandro, Pellegrini, Lucienne, Pieraccini, Alberto, Pinto-Vraca, Tiziana, Ribaldone, Davide, Rizzuto, Giulia, Roselli, Jenny, Santacroce, Giovanni, Todeschini, Alessia, Vernero, Marta, Viola, Anna, Zammarchi, Irene, Bergamaschi, Gaetano, Castiglione, Fabiana, D'Incà, Renata, Astegiano, Marco, Fries, Walter, Milla, Monica, Ciacci, Carolina, Rizzello, Fernando, Saibeni, Simone, Ciccocioppo, Rachele, Orlando, Ambrogio, Bossa, Fabrizio, Principi, Mariabeatrice, Vernia, Piero, Ricci, Chiara, Scribano, Maria L., Bodini, Giorgia, Mazzucco, Dario, Bassotti, Gabrio, Riegler, Gabriele, Buda, Andrea, Neri, Matteo, Caprioli, Flavio, Monica, Fabio, Manca, Aldo, Villa, Erica, Fiorino, Gionata, Aronico, Nicola, Lenti, Marco V., Mengoli, Caterina, Testa, Anna, Vecchi, Maurizio, Klersy, Catherine, and Di Sabatino, Antonio

Published
2024
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6. List of contributors

Author

Aimo, Cristina, primary, Aronico, Nicola, additional, Auricchio, Renata, additional, Barone, Michele, additional, Biagi, Federico, additional, Bianchi, Paola Ilaria, additional, Bibbò, Stefano, additional, Broglio, Giacomo, additional, Caio, Giacomo, additional, Calabrese, Emma, additional, Cammarota, Giovanni, additional, Caproni, Marzia, additional, Carroccio, Antonio, additional, Castellaneta, Stefania, additional, Catassi, Carlo, additional, Catassi, Giulia, additional, Ciacci, Carolina, additional, Ciccocioppo, Rachele, additional, Copparoni, Roberto, additional, Corazza, Gino Roberto, additional, Corrà, Alberto, additional, Cristofori, Fernanda, additional, Dargenio, Vanessa Nadia, additional, De Giorgio, Roberto, additional, De Lisi, Giuseppe, additional, De Micco, Ida, additional, Di Sabatino, Antonio, additional, Di Stasio, Luigia, additional, Di Stefano, Michele, additional, Discepolo, Valentina, additional, Fasano, Alessio, additional, Francavilla, Ruggiero, additional, Gasbarrini, Antonio, additional, Gasbarrini, Giovanni, additional, Gatti, Simona, additional, Gianfrani, Carmen, additional, Giuliano, Alessandra, additional, Greco, Luigi, additional, Guandalini, Stefano, additional, Ianiro, Gianluca, additional, Lenti, Marco Vincenzo, additional, Lionetti, Elena, additional, Lucioni, Marco, additional, Maimaris, Stiliano, additional, Mamone, Gianfranco, additional, Mandile, Roberta, additional, Mansueto, Pasquale, additional, Marafini, Irene, additional, Mariotti, Elena Biancamaria, additional, Mengoli, Caterina, additional, Monteleone, Giovanni, additional, Monteleone, Ivan, additional, Neuhold, Susanna, additional, Novellino, Luisa, additional, Pilo, Caterina, additional, Plutino, Giuseppe, additional, Sansotta, Naire, additional, Santacroce, Giovanni, additional, Schiepatti, Annalisa, additional, Seidita, Aurelio, additional, Silano, Marco, additional, Troncone, Edoardo, additional, Troncone, Riccardo, additional, Vanoli, Alessandro, additional, Vitale, Serena, additional, Volta, Umberto, additional, Zanini, Annalisa, additional, and Zingone, Fabiana, additional

Published
2024
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11. Diagnostic delay in adult coeliac disease: An Italian multicentre study

Author

Lenti, Marco Vincenzo, Aronico, Nicola, Bianchi, Paola Ilaria, D'Agate, Carmela Cinzia, Neri, Matteo, Volta, Umberto, Mumolo, Maria Gloria, Astegiano, Marco, Calabrò, Antonino Salvatore, Zingone, Fabiana, Latella, Giovanni, Di Sario, Antonio, Carroccio, Antonio, Ciacci, Carolina, Luzza, Francesco, Bagnato, Carmela, Fantini, Massimo Claudio, Elli, Luca, Cammarota, Giovanni, Gasbarrini, Antonio, Portincasa, Piero, Latorre, Mario Andrea, Petrucci, Clarissa, Quatraccioni, Claudia, Iannelli, Chiara, Vecchione, Nicoletta, Rossi, Carlo Maria, Broglio, Giacomo, Ianiro, Gianluca, Marsilio, Ilaria, Bibbò, Stefano, Marinoni, Beatrice, Tomaselli, Donatella, Abenavoli, Ludovico, Pilia, Riccardo, Santacroce, Giovanni, Lynch, Erica, Carrieri, Antonella, Mansueto, Pasquale, Gabba, Margherita, Alunno, Giacomo, Rossi, Chiara, Onnis, Francesca, Efthymakis, Konstantinos, Cesaro, Nicola, Vernero, Marta, Baiano Svizzero, Federica, Semeraro, Francesco Paolo, Silano, Marco, Vanoli, Alessandro, Klersy, Catherine, Corazza, Gino Roberto, and Di Sabatino, Antonio

Published
2023
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12. Nutritional Consequences of Celiac Disease and Gluten-Free Diet.

Author

Bianchi, Paola Ilaria, Aronico, Nicola, Santacroce, Giovanni, Broglio, Giacomo, Lenti, Marco Vincenzo, and Di Sabatino, Antonio

Subjects
CELIAC disease, GLUTEN-free diet, GLUTEN allergenicity, MALNUTRITION, DIET in disease
Abstract

Celiac disease is an immune-mediated condition triggered by gluten ingestion in genetically predisposed individuals. The global prevalence of celiac disease is significant, affecting approximately 1.4% of women and 0.7% of men, with incidence rates of 17.4 and 7.8 per 100,000 person-years, respectively. The clinical presentation of celiac disease may range from overt diarrhea and malabsorption to more subtle features such as nutritional deficiencies and extraintestinal manifestations. It is the most common cause of global malabsorption in Western countries. A life-long gluten-free diet is the only available treatment for celiac disease. Moreover, a gluten-free diet is often adopted by individuals without celiac disease, either to address non-celiac gluten sensitivity or for other reasons. This review aims to explore the current understandings of the nutritional consequences of untreated celiac disease and the impact of the gluten-free diet itself. Physicians and dietitians specializing in celiac disease should focus on providing a well-rounded nutritional scheme to address deficiencies caused by the disease and prevent the instauration of new nutritional imbalances. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Opening the doors of precision medicine: novel tools to assess intestinal barrier in inflammatory bowel disease and colitis-associated neoplasia

Author

Iacucci, Marietta, primary, Santacroce, Giovanni, additional, Majumder, Snehali, additional, Morael, Jennifer, additional, Zammarchi, Irene, additional, Maeda, Yasuharu, additional, Ryan, David, additional, Di Sabatino, Antonio, additional, Rescigno, Maria, additional, Aburto, Maria R, additional, Cryan, John F, additional, and Ghosh, Subrata, additional

Published
2024
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15. Endocytoscopy with automated multispectral intestinal barrier pathology imaging for assessment of deep healing to predict outcomes in ulcerative colitis.

Author

Majumder, Snehali, Santacroce, Giovanni, Yasuharu Maeda, Zammarchi, Irene, Puga-Tejada, Miguel, Ditonno, Ilaria, Hayes, Brian, Crotty, Rory, Fennell, Eanna, Shivaji, Uday N., Abdawn, Zainab, Hejmadi, Rahul, Parigi, Tommaso Lorenzo, Nardone, Olga Maria, Murray, Paul, Burke, Louise, Ghosh, Subrata, and Iacucci, Marietta

Subjects
MACHINE learning, INFLAMMATORY bowel diseases, RANK correlation (Statistics), ULCERATIVE colitis, BRITISH kings & rulers, CHOLANGITIS
Published
2024
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16. Follow-up evaluation and management of anemia in inflammatory bowel disease: A study by the Italian Group for Inflammatory Bowel Diseases (IG-IBD)

Author

Bergamaschi, Gaetano, primary, Castiglione, Fabiana, additional, D'Incà, Renata, additional, Astegiano, Marco, additional, Fries, Walter, additional, Milla, Monica, additional, Ciacci, Carolina, additional, Rizzello, Fernando, additional, Saibeni, Simone, additional, Ciccocioppo, Rachele, additional, Orlando, Ambrogio, additional, Bossa, Fabrizio, additional, Principi, Mariabeatrice, additional, Vernia, Piero, additional, Ricci, Chiara, additional, Scribano, Maria L., additional, Bodini, Giorgia, additional, Mazzucco, Dario, additional, Bassotti, Gabrio, additional, Riegler, Gabriele, additional, Buda, Andrea, additional, Neri, Matteo, additional, Caprioli, Flavio, additional, Monica, Fabio, additional, Manca, Aldo, additional, Villa, Erica, additional, Fiorino, Gionata, additional, Aronico, Nicola, additional, Lenti, Marco V., additional, Mengoli, Caterina, additional, Testa, Anna, additional, Vecchi, Maurizio, additional, Klersy, Catherine, additional, Di Sabatino, Antonio, additional, Amodeo, Giuseppe, additional, Antonelli, Elisabetta, additional, Bertetti, Noemi, additional, Bezzio, Cristina, additional, Campigotto, Michele, additional, Caccaro, Roberta, additional, De Bona, Manuela, additional, Della Corte, Cristina, additional, Demarzo, Maria G., additional, Falasco, Giuliano, additional, Fontana, Rosanna, additional, Gionchetti, Paolo, additional, Iovino, Paola, additional, Lepore, Federica, additional, Lorenzon, Greta, additional, Marasco, Veronica, additional, Paolini, Alessandro, additional, Pellegrini, Lucienne, additional, Pieraccini, Alberto, additional, Pinto-Vraca, Tiziana, additional, Ribaldone, Davide, additional, Rizzuto, Giulia, additional, Roselli, Jenny, additional, Santacroce, Giovanni, additional, Todeschini, Alessia, additional, Vernero, Marta, additional, Viola, Anna, additional, and Zammarchi, Irene, additional

Published
2024
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17. Eosinophilic esophagitis in the era of biologics.

Author

Rossi, Carlo Maria, Santacroce, Giovanni, Lenti, Marco Vincenzo, and di Sabatino, Antonio

Subjects
NATURAL history, BIOLOGICALS, BIOAVAILABILITY, EOSINOPHILIC esophagitis, BIOTHERAPY, ESOPHAGUS
Abstract

Eosinophilic esophagitis (EoE) is a chronic inflammatory, disabling disorder characterized by prominent eosinophilic inflammation of the esophagus, leading to troublesome symptoms including dysphagia and food impaction. The natural history of EoE is poorly known, but it may lead to esophageal strictures. The therapeutic armamentarium is expected to grow in the near future, especially due to the availability of novel biological therapies targeting crucial inflammatory pathways of EoE. In this review, we discuss the main clinical features and natural history of EoE, focusing on the current therapeutic strategies, as well as past and current trials investigating biologics for its treatment. Dupilumab has been the first approved biologic drug for the treatment of EoE; long-term studies assessing how it could change the natural history of EoE are awaited. Novel biological drugs or other molecules are currently under study and could change the current treatment algorithms in the near future. Proper drug positioning and long term 'exit strategies' are yet to be defined. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Diagnostic delay in symptomatic uncomplicated diverticular disease: an Italian tertiary referral centre study

Author

Santacroce, Giovanni, primary, Lenti, Marco Vincenzo, additional, Abruzzese, Giulia Maria, additional, Alunno, Giacomo, additional, Di Terlizzi, Francesco, additional, Frenna, Carmine, additional, Gentile, Antonella, additional, Latorre, Mario Andrea, additional, Petrucci, Clarissa, additional, Ruggeri, Damiano, additional, Soriano, Simone, additional, Aronico, Nicola, additional, Rossi, Carlo Maria, additional, De Silvestri, Annalisa, additional, Corazza, Gino Roberto, additional, and Di Sabatino, Antonio, additional

Published
2023
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21. Present and future of endoscopy precision for inflammatory bowel disease.

Author

Santacroce, Giovanni, Zammarchi, Irene, Tan, Chin Kimg, Coppola, Gaetano, Varley, Rachel, Ghosh, Subrata, and Iacucci, Marietta

Subjects
*INFLAMMATORY bowel diseases, *ENDOSCOPIC surgery, *ENDOSCOPY, *INDIVIDUALIZED medicine, *PRECISION farming, *ARTIFICIAL intelligence, *CLINICAL medicine
Abstract

Several advanced imaging techniques are now available for endoscopists managing inflammatory bowel disease (IBD) patients. These tools, including dye‐based and virtual chromoendoscopy, probe‐based confocal laser endomicroscopy and endocytoscopy, are increasingly innovative applications in clinical practice. They allow for a more in‐depth and refined evaluation of the mucosal and vascular bowel surface, getting closer to histology. They have demonstrated a remarkable ability in assessing intestinal inflammation, histologic remission, and predicting relapse and favorable long‐term outcomes. In addition, the future application of molecular endoscopy to predict biological drug responses has yielded preliminary but encouraging results. Furthermore, these techniques are crucial in detecting and characterizing IBD‐related dysplasia, assisting endoscopic mucosal resection and submucosal dissection towards a surgery‐sparing approach. Artificial intelligence (AI) holds great potential in this promising landscape, as it can provide an objective and reproducible assessment of inflammation and dysplasia. Moreover, it can improve the prediction of outcomes and aid in subsequent therapeutic decision‐making. This review aims to summarize the promising role of state‐of‐the‐art advanced endoscopic techniques and related AI‐enabled models for managing IBD, paving the way for precision medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Clinical and Histopathological Features of an Italian Monocentric Series of Primary Small Bowel T-Cell Lymphomas

Author

Lucioni, Marco, primary, Fraticelli, Sara, additional, Santacroce, Giovanni, additional, Bonometti, Arturo, additional, Aronico, Nicola, additional, Sciarra, Roberta, additional, Lenti, Marco Vincenzo, additional, Bianchi, Paola Ilaria, additional, Neri, Giuseppe, additional, Feltri, Monica, additional, Neri, Benedetto, additional, Ferrario, Giuseppina, additional, Riboni, Roberta, additional, Corazza, Gino Roberto, additional, Vanoli, Alessandro, additional, Arcaini, Luca, additional, Paulli, Marco, additional, and Di Sabatino, Antonio, additional

Published
2023
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25. Enhancing Ulcerative Colitis Histological Image Segmentation with an Active Learning Framework

Author

García Torres, Fernando, Santacroce, Giovanni, Zammarchi, Irene, Meseguer, Pablo, Amor, Rocío del, Hayes, Brian, Cotty, Rory, Ghosh, Subrata, Iacucci, Marietta, Naranjo, Valery, García Torres, Fernando, Santacroce, Giovanni, Zammarchi, Irene, Meseguer, Pablo, Amor, Rocío del, Hayes, Brian, Cotty, Rory, Ghosh, Subrata, Iacucci, Marietta, and Naranjo, Valery

Abstract

In the management of UC, a chronic inflammatory bowel disease, histological evaluation plays an essential role in tar- geting histological remission (HR) of intestinal inflammatory activity as the primary aim of treatment. Recent work in the field has proposed a novel index called PHRI that quantifies UC activity based on the presence or absence of neutrophils in different cellular compartments: lamina propria, cryptal epithelium, surface epithelium and cryptal lumen. Digiti- zation of tissue samples into whole-slide images (WSI) has permitted the implementation of computer vision algorithms. These can perform tasks such as semantic segmentation but they require detailed pixel-level annotations, which are labo- rious and time-consuming in gigapixel images such as WSI. To address this limitation, this work introduces an active learning (AL) algorithm, an innovative approach to alleviat- ing the workload of pathologists by improving the efficiency in identifying crucial regions in these images for UC diag- nosis. Leveraging a diverse database of annotated WSI and an iterative training process, the aim is to optimize the per- formance of the encoder-decoder-based segmentation model.

Published
2023

35. Impact of COVID‐19 in immunosuppressive drug‐naïve autoimmune disorders: Autoimmune gastritis, celiac disease, type 1 diabetes, and autoimmune thyroid disease

Author

Santacroce, Giovanni, primary, Lenti, Marco Vincenzo, additional, Aronico, Nicola, additional, Miceli, Emanuela, additional, Lovati, Elisabetta, additional, Lucotti, Pietro Carlo, additional, Coppola, Luigi, additional, Gentile, Antonella, additional, Latorre, Mario Andrea, additional, Di Terlizzi, Francesco, additional, Soriano, Simone, additional, Frigerio, Chiara, additional, Pellegrino, Ivan, additional, Pasini, Alessandra, additional, Ubezio, Cristina, additional, Mambella, Jacopo, additional, Canta, Roberta, additional, Fusco, Alessandra, additional, Rigano, Giovanni, additional, and Di Sabatino, Antonio, additional

Published
2022
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36. Liver-spleen axis dysfunction in COVID-19

Author

Cococcia, Sara, primary, Lenti, Marco Vincenzo, additional, Santacroce, Giovanni, additional, Achilli, Giovanna, additional, Borrelli de Andreis, Federica, additional, and Di Sabatino, Antonio, additional

Published
2021
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38. Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy

Author

Melazzini, Federica, Colaneri, Marta, Fumoso, Federica, Freddi, Giulia, Lenti, Marco Vincenzo, Pieri, Teresa Chiara, Piloni, Davide, Noris, Patrizia, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Corsico, Angelo, Tavazzi, Guido, Baldanti, Fausto, Triarico, Antonio, Mojoli, Francesco, Bruno, Raffaele, Di Sabatino, Antonio, Aronico, Nicola, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Delliponti, Angela, Derosa, Giuseppe, Di Stefano, Michele, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, de Andreis, Federica Borrelli, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Merli, Stefania, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pellegrino, Ivan, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Romito, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, Stefani, Debora, Aliberti, Anna Rita, Amatu, Alessandro, Anfossi, Laura, Arisi, Eric, Baldi, Chiara, Belliato, Mirko, Bellini, Lorenzo, Benzi, Alberto, Bichisao, Germana, Bolongaro, Antonia, Bottazzi, Andrea, Broglia, Federica, Bruschi, Giacomo, Caneva, Luca, Capaccio, Emanuele, Carboni, Valeria, Cavalloro, Fabrizio, Ciceri, Maria, Civardi, Luca, Delmonte, Maria Paola, Domenegati, Elisa Lucia, Ferrari, Federica, Ferrari, Fiorenza, Ferrari, Marta, Fuardo, Marinella, Gerletti, Maddalena Margherita, Gualdana, Simonetta, Ilardi, Marcella, Lo Coco, Claudia, Maggio, Giuseppe, Mascia, Maria Benedetta, Mencherini, Simonetta, Merati, Paola Maria, Mongodi, Silvia, Mori, Anna Maria, Morgante, Federica, Niebel, Thekla Larissa, Noli, Silvano, Orlando, Anita, Pagani, Michele, Passador, Debora, Pellicori, Simona, Perotti, Luciano, Picchioni, Raffaella, Poma, Silvia, Pozzi, Marco, Preti, Emanuela, Puce, Roberta, Radolovich, Danila Katia, Ragni, Gianluca, Repossi, Filippo, Riccardi, Francesca, Rizzardi, Roberto, Rodi, Giuseppe, Roldi, Emanuela, Rossi, Cristina, Sala Gallini, Giuseppe, Sciutti, Fabio, Sportiello, Debora, Ticozzelli, Giulia, Visconti, Federico, Zizzi, Silvia, Bagliani, Alessandro, Belotti, Corrado, Bossi, Chiara, Colombo, Andrea, Colombo, Costanza Natalia Julia, Cremascoli, Luca, Dammassa, Valentino, Discepoli, Roberto, Garlando, Maria Adelaide, Grandini, Filippo, Pellegrini, Andrea, Quaranta, Cecilia, Stella, Andrea, Torresani, Francesco, Mondelli, Mario, Brunetti, Enrico, Di Matteo, Angela, Seminari, Elena, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Asperges, Erika, Di Filippo, Alessandro, Sambo, Margherita, Biscarini, Simona, Lupi, Matteo, Roda, Silvia, Gallazzi, Ilaria, Sachs, Michele, Valsecchi, Pietro, Ferrari, Alessandra, Bosio, Matteo, Cascina, Alessandro, Conio, Valentina, Di Domenica, Rita, Donnetta, Anna, Fraolini, Elia, Gualtieri, Giuseppe, Mangiarotti, Patrizia, Mariani, Francesca, Meloni, Federica, Oggionni, Tiberio, Pasturenzi, Lidia, Ronzoni, Vanessa, Saracino, Laura, Stella, Giulia, Tomaselli, Stefano, Abbate, Tommaso, Accordino, Giulia, Bertuccio, Francesco, Burattini, Cecilia, Cacciatore, Elisa, Cattaneo, Elena, Chino, Vittorio, Coretti, Manuela, Della Zoppa, Matteo, Infusino, Cristina, Lettieri, Sara, Maccabruni, Valeria, Mancinelli, Silvia, Tirelli, Claudio, and Vertui, Valentina

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), 030204 cardiovascular system & hematology, Single Center, Tertiary referral hospital, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, Medicine, cardiovascular diseases, Mean platelet volume, biology, SARS-CoV-2, business.industry, Pulmonary embolism, C-reactive protein, Anticoagulants, Thrombosis, equipment and supplies, medicine.disease, Im - Original, 030220 oncology & carcinogenesis, biology.protein, Emergency Medicine, Observational study, business
Abstract

Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score > 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p p p = 0.002 and p = 0.005, respectively). No significant difference was found in d-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.

Published
2020
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39. Anemia in patients with Covid-19: pathogenesis and clinical significance

Author

Bergamaschi, Gaetano, Borrelli de Andreis, Federica, Aronico, Nicola, Lenti, Marco Vincenzo, Barteselli, Chiara, Merli, Stefania, Pellegrino, Ivan, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Mordà, Francesco, Lapia, Francesco, Ferrari, Sara, Ballesio, Alessia, Parodi, Alessandro, Calabretta, Francesca, Ferrari, Maria Giovanna, Fumoso, Federica, Gentile, Antonella, Melazzini, Federica, Di Sabatino, Antonio, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Derosa, Giuseppe, Stefano, Michele Di, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Noris, Patrizia, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Pieresca, Carla, Preti, Paola Stefania, Russo, Maria Concetta, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Banfi, Francesco, Benedetti, Irene, Brattoli, Michele, Cambiè, Ginevra, Canta, Roberta, Cococcia, Sara, Conca, Federico, Delliponti, Mariangela, Rio, Virginia Del, Terlizzi, Francesco Di, Fiengo, Anna, Forni, Tommaso, Freddi, Giulia, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Nardone, Alba, Pace, Luca, Padovini, Lucia, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, and Stefani, Debora

Subjects
0301 basic medicine, Male, Comorbidity, Gastroenterology, Hemoglobins, 0302 clinical medicine, Medicine, Cholinesterases, Hematology, biology, medicine.diagnostic_test, Anemia, Iron-Deficiency, Oxygen partial pressure/oxygen concentration, Anemia, General Medicine, Middle Aged, C-Reactive Protein, 030220 oncology & carcinogenesis, Erythrocyte sedimentation rate, Original Article, Female, Adult, medicine.medical_specialty, Blood Sedimentation, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Red blood cell distribution width, Internal medicine, Humans, Clinical significance, Aged, L-Lactate Dehydrogenase, business.industry, SARS-CoV-2, C-reactive protein, COVID-19, Correction, medicine.disease, Ferritin, Oxygen, 030104 developmental biology, Ferritins, biology.protein, Erythrocyte Count, Hemoglobin, business, Anemia of inflammation, Blood Gas Monitoring, Transcutaneous
Abstract

COVID-19 patients typically present with lower airway disease, although involvement of other organ systems is usually the rule. Hematological manifestations such as thrombocytopenia and reduced lymphocyte and eosinophil numbers are highly prevalent in COVID-19 and have prognostic significance. Few data, however, are available about the prevalence and significance of anemia in COVID-19. In an observational study, we investigated the prevalence, pathogenesis and clinical significance of anemia among 206 patients with COVID-19 at the time of their hospitalization in an Internal Medicine unit. The prevalence of anemia was 61% in COVID-19, compared with 45% in a control group of 71 patients with clinical and laboratory findings suggestive of COVID-19, but nasopharyngeal swab tests negative for SARS-CoV-2 RNA (p = 0.022). Mortality was higher in SARS-CoV-2 positive patients. In COVID-19, females had lower hemoglobin concentration than males and a higher prevalence of moderate/severe anemia (25% versus 13%, p = 0.032). In most cases, anemia was mild and due to inflammation, sometimes associated with iron and/or vitamin deficiencies. Determinants of hemoglobin concentration included: erythrocyte sedimentation rate, serum cholinesterase, ferritin and protein concentrations and number of chronic diseases affecting each patient. Hemoglobin concentration was not related to overall survival that was, on the contrary, influenced by red blood cell distribution width, age, lactate dehydrogenase and the ratio of arterial partial oxygen pressure to inspired oxygen fraction. In conclusion, our results highlight anemia as a common manifestation in COVID-19. Although anemia does not directly influence mortality, it usually affects elderly, frail patients and can negatively influence their quality of life.

Published
2020

40. Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy

Author

Lenti, Marco Vincenzo, Borrelli de Andreis, Federica, Pellegrino, Ivan, Klersy, Catherine, Merli, Stefania, Miceli, Emanuela, Aronico, Nicola, Mengoli, Caterina, Di Stefano, Michele, Cococcia, Sara, Santacroce, Giovanni, Soriano, Simone, Melazzini, Federica, Delliponti, Mariangela, Baldanti, Fausto, Triarico, Antonio, Corazza, Gino Roberto, Pinzani, Massimo, Di Sabatino, Antonio, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Derosa, Giuseppe, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mugellini, Amedeo, Muggia, Chiara, Noris, Patrizia, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Torello Vjera, Francesca, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Freddi, Giulia, Frigerio, Chiara, Fumoso, Federica, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Savioli, Jessica, Spataro, Carmine, and Stefani, Debora

Subjects
Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, 030204 cardiovascular system & hematology, Acute respiratory failure, Chronic liver disease, Hepatitis, 03 medical and health sciences, 0302 clinical medicine, Intensive care, Internal medicine, Patients' Rooms, medicine, Internal Medicine, Humans, 030212 general & internal medicine, Pandemics, Aged, Retrospective Studies, Aged, 80 and over, Liver injury, medicine.diagnostic_test, business.industry, COVID-19, Retrospective cohort study, Middle Aged, medicine.disease, Im - Original, Coronavirus, Hospitalization, Severe acute respiratory syndrome, Italy, Liver, Emergency Medicine, Female, Liver function, Coronavirus Infections, business, Liver function tests, Liver Failure
Abstract

Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO2/FiO2

Published
2020
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41. QTc Interval and Mortality in a Population of SARS-2-CoV Infected Patients

Author

Vicentini, Alessandro, primary, Masiello, Lucrezia, additional, D’Amore, Sabato, additional, Baldi, Enrico, additional, Ghio, Stefano, additional, Savastano, Simone, additional, Sanzo, Antonio, additional, Di Matteo, Angela, additional, Seminari, Elena Maria, additional, Lenti, Marco Vincenzo, additional, Bosio, Matteo, additional, Petracci, Barbara, additional, Frigerio, Laura, additional, Sabena, Anna, additional, Tavazzi, Guido, additional, Oltrona Visconti, Luigi, additional, Rordorf, Roberto, additional, Gnecchi, Massimiliano, additional, Totaro, Rossana, additional, Ferlini, Marco, additional, Greco, Alessandra, additional, Magrini, Giulia, additional, Scelsi, Laura, additional, Acquaro, Mauro, additional, Coccia, Michela, additional, Digiacomo, Simonluca, additional, Foglia, Davide, additional, Jeva, Francesco, additional, Montalto, Claudio, additional, Moschella, Martina, additional, Pezza, Laura, additional, Perlini, Stefano, additional, Alfano, Claudia, additional, Bonzano, Marco, additional, Briganti, Federica, additional, Crescenzi, Giuseppe, additional, Falchi, Anna Giulia, additional, Maggi, Elena, additional, Guarnone, Roberta, additional, Guglielmana, Barbara, additional, Martino, Ilaria Francesca, additional, Pioli Di Marco, Maria Serena, additional, Pettenazza, Pietro, additional, Quaglia, Federica, additional, Salinaro, Francesco, additional, Speciale, Francesco, additional, Zunino, Ilaria, additional, Sturniolo, Giulia, additional, Bracchi, Federico, additional, Lago, Elena, additional, Corsico, Angelo, additional, Piloni, Davide, additional, Accordino, Giulia, additional, Burattini, Cecilia, additional, Di Sabatino, Antonio, additional, Pellegrino, Ivan, additional, Soriano, Simone, additional, Santacroce, Giovanni, additional, Parodi, Alessandro, additional, de Andreis, Federica Borrelli, additional, Bruno, Raffaele, additional, Zuccaro, Valentina, additional, Moioli, Francesco, additional, Dammassi, Valentino, additional, and Albertini, Riccardo, additional

Published
2020
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43. Correction to: Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy

Author

Melazzini, Federica, Colaneri, Marta, Fumoso, Federica, Freddi, Giulia, Lenti, Marco Vincenzo, Pieri, Teresa Chiara, Piloni, Davide, Noris, Patrizia, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Corsico, Angelo, Tavazzi, Guido, Baldanti, Fausto, Triarico, Antonio, Mojoli, Francesco, Bruno, Raffaele, Di Sabatino, Antonio, Aronico, Nicola, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Delliponti, Angela, Derosa, Giuseppe, Di Stefano, Michele, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, Borrelli de Andreis, Federica, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Merli, Stefania, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pellegrino, Ivan, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Romito, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, Stefani, Debora, Aliberti, Anna Rita, Amatu, Alessandro, Anfossi, Laura, Arisi, Eric, Baldi, Chiara, Belliato, Mirko, Bellini, Lorenzo, Benzi, Alberto, Bichisao, Germana, Bolongaro, Antonia, Bottazzi, Andrea, Broglia, Federica, Bruschi, Giacomo, Caneva, Luca, Capaccio, Emanuele, Carboni, Valeria, Cavalloro, Fabrizio, Ciceri, Maria, Civardi, Luca, Delmonte, Maria Paola, Domenegati, Elisa Lucia, Ferrari, Federica, Ferrari, Fiorenza, Ferrari, Marta, Fuardo, Marinella, Gerletti, Maddalena Margherita, Gualdana, Simonetta, Ilardi, Marcella, Lo Coco, Claudia, Maggio, Giuseppe, Mascia, Maria Benedetta, Mencherini, Simonetta, Merati, Paola Maria, Mongodi, Silvia, Mori, Anna Maria, Morgante, Federica, Niebel, Thekla Larissa, Noli, Silvano, Orlando, Anita, Pagani, Michele, Passador, Debora, Pellicori, Simona, Perotti, Luciano, Picchioni, Raffaella, Poma, Silvia, Pozzi, Marco, Preti, Emanuela, Puce, Roberta, Radolovich, Danila Katia, Ragni, Gianluca, Repossi, Filippo, Riccardi, Francesca, Rizzardi, Roberto, Rodi, Giuseppe, Roldi, Emanuela, Rossi, Cristina, Sala Gallini, Giuseppe, Sciutti, Fabio, Sportiello, Debora, Ticozzelli, Giulia, Visconti, Federico, Zizzi, Silvia, Bagliani, Alessandro, Belotti, Corrado, Bossi, Chiara, Colombo, Andrea, Colombo, Costanza Natalia Julia, Cremascoli, Luca, Dammassa, Valentino, Discepoli, Roberto, Garlando, Maria Adelaide, Grandini, Filippo, Pellegrini, Andrea, Quaranta, Cecilia, Stella, Andrea, Torresani, Francesco, Mondelli, Mario, Brunetti, Enrico, Di Matteo, Angela, Seminari, Elena, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Asperges, Erika, Di Filippo, Alessandro, Sambo, Margherita, Biscarini, Simona, Lupi, Matteo, Roda, Silvia, Gallazzi, Ilaria, Sachs, Michele, Valsecchi, Pietro, Ferrari, Alessandra, Bosio, Matteo, Cascina, Alessandro, Conio, Valentina, Di Domenica, Rita, Donnetta, Anna, Fraolini, Elia, Gualtieri, Giuseppe, Mangiarotti, Patrizia, Mariani, Francesca, Meloni, Federica, Oggionni, Tiberio, Pasturenzi, Lidia, Ronzoni, Vanessa, Saracino, Laura, Stella, Giulia, Tomaselli, Stefano, Abbate, Tommaso, Accordino, Giulia, Bertuccio, Francesco, Burattini, Cecilia, Cacciatore, Elisa, Cattaneo, Elena, Chino, Vittorio, Coretti, Manuela, Della Zoppa, Matteo, Infusino, Cristina, Lettieri, Sara, Maccabruni, Valeria, Mancinelli, Silvia, Tirelli, Claudio, and Vertui, Valentina

Subjects
Adult, Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), MEDLINE, Tertiary referral hospital, Single Center, Statistics, Nonparametric, Tertiary Care Centers, Prevalence, Internal Medicine, medicine, Humans, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Aged, Retrospective Studies, Aged, 80 and over, Academic Medical Centers, Task force, business.industry, Correction, COVID-19, Venous Thromboembolism, Middle Aged, Northern italy, Italy, Emergency medicine, Emergency Medicine, Female, business, Venous thromboembolism
Abstract

Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p 0.0001) or lactate dehydrogenase (LDH) (p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p 0.0001). Platelet-to-lymphocyte ratio significantly correlated with CRP (p 0.0001). The majority of VTE patients was male and younger compared to non-VTE patients (p = 0.002 and p = 0.005, respectively). No significant difference was found in D-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.

Published
2021
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45. Recurrence of angina after ST-segment elevation myocardial infarction: the role of coronary microvascular obstruction

Author

Montone, Rocco A, primary, Vetrugno, Vincenzo, additional, Santacroce, Giovanni, additional, Del Buono, Marco Giuseppe, additional, Meucci, Maria Chiara, additional, Camilli, Massimiliano, additional, Galli, Mattia, additional, Leone, Antonio M, additional, D’Amario, Domenico, additional, Buffon, Antonio, additional, Aurigemma, Cristina, additional, Burzotta, Francesco, additional, Trani, Carlo, additional, Niccoli, Giampaolo, additional, and Crea, Filippo, additional

Published
2019
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46. 154 Recurrence of angina after ST-elevation myocardial infarction: the role of microvascular obstruction

Author

Vetrugno, Vincenzo, primary, Montone, Rocco A., additional, Fracassi, Francesco, additional, Vergni, Federico, additional, Russo, Michele, additional, Del Buono, Marco G., additional, Santacroce, Giovanni, additional, Camilli, Massimiliano, additional, Gurguglione, Filippo L., additional, Meucci, M. Chiara, additional, Niccoli, Giampaolo, additional, and Crea, Filippo, additional

Published
2019
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47. Recurrence of angina after ST-segment elevation myocardial infarction: the role of coronary microvascular obstruction

Author

Montone, Rocco A, Vetrugno, Vincenzo, Santacroce, Giovanni, Del Buono, Marco Giuseppe, Meucci, Maria Chiara, Camilli, Massimiliano, Galli, Mattia, Leone, Antonio M, D’Amario, Domenico, Buffon, Antonio, Aurigemma, Cristina, Burzotta, Francesco, Trani, Carlo, Niccoli, Giampaolo, and Crea, Filippo

Abstract

Background: The recurrence of angina after percutaneous coronary intervention affects 20–35% of patients with stable coronary artery disease; however, few data are available in the setting of ST-segment elevation myocardial infarction. We evaluated the relation between coronary microvascular obstruction and the recurrence of angina at follow-up.Methods: We prospectively enrolled patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Microvascular obstruction was defined as thrombolysis in myocardial infarction flow less than 3 or 3 with myocardial blush grade less than 2. The primary endpoint was the recurrence of angina at follow-up. Moreover, angina status was evaluated by the Seattle angina questionnaire summary score (SAQSS). Therapy at follow-up and the occurrence of major adverse cardiovascular events were also collected.Results: We enrolled 200 patients. Microvascular obstruction occurred in 52 (26%) of them. Follow-up (mean time 25.17±9.28 months) was performed in all patients. Recurrent angina occurred in 31 (15.5%) patients, with a higher prevalence in patients with microvascular obstruction compared with patients without microvascular obstruction (13 (25.0%) vs. 18 (12.2%), P=0.008). Accordingly, SAQSS was lower and the need for two or more anti-anginal drugs was higher in patients with microvascular obstruction compared with patients without microvascular obstruction. At multiple linear regression analysis a history of previous acute coronary syndrome and the occurrence of microvascular obstruction were the only independent predictors of a worse SAQSS. Finally, the occurrence of major adverse cardiovascular events was higher in patients with microvascular obstruction compared with patients without microvascular obstruction.Conclusions: The recurrence of angina in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention is an important clinical issue. The occurrence of microvascular obstruction portends a worse angina status and is associated with the use of more anti-anginal drugs.

Published
2024
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48. Rare Case of Male Breast Cancer and Axillary Lymphoma in the Same Patient: An Unique Case Report

Author

Sordi, Emiliano, Cagossi, Katia, Lazzaretti, Maria Grazia, Gusolfino, Daniel, Artioli, Fabrizio, Santacroce, Giovanni, Brandi, Maria Luisa, and Piscitelli, Prisco

Subjects
Article Subject, skin and connective tissue diseases
Abstract

Breast cancer in men is uncommon, and even more rare is the simultaneous presentation of two different malignancies. A 39-year-old man was diagnosed with both breast cancer and axillary lymphoma. Familiar history revealed that his mother died because of breast cancer. The patient underwent fine needle aspiration leading to the diagnosis of malignant lesion. Modified radical mastectomy was performed. Histology revealed an infiltrating ductal carcinoma 2.8 cm wide, grade 2, with vascular and lymphatic invasion. Surprisingly, one of the second level nodes was confirmed as a high-grade large B cell non-Hodgkin's lymphoma. No family inheritance or gene mutations (BRCA 1 and 2) were found. The patient underwent local radiotherapy, followed by 6 chemotherapy courses (RCHOP) and treatment with tamoxifen 20 mg/daily. To our knowledge, this is the first case reported in literature of male breast cancer and axillary lymphoma simultaneously confirmed in the same patient.

Published
2011
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50. Artificial intelligence-enabled histology exhibits comparable accuracy to pathologists in assessing histological remission in Ulcerative Colitis: a systematic review, meta-analysis and meta-regression.

Author

Puga-Tejada M, Majumder S, Maeda Y, Zammarchi I, Ditonno I, Santacroce G, Capobianco I, Robles-Medranda C, Ghosh S, and Iacucci M

Abstract

Background and Aims: Achieving histological remission is a desirable emerging treatment target in Ulcerative Colitis (UC), yet its assessment is challenging due to high inter- and intra-observer variability, reliance on experts, and lack of standardisation. Artificial intelligence (AI) holds promise in addressing these issues. This systematic review, meta-analysis, and meta-regression evaluated the AI's performance in assessing histological remission and compared it with that of pathologists., Methods: We searched Medline/PubMed and Scopus databases from inception to September 2024. We included studies on AI models assessing histological activity in UC, with or without comparison to pathologists. Pooled performance metrics were calculated: sensitivity, specificity, positive and negative predictive value (PPV & NPV), observed agreement, and F1 score. A pairwise meta-analysis compared AI and pathologists, while sub-meta-analysis and meta-regression evaluated heterogeneity and factors influencing AI performance., Results: Twelve studies met the inclusion criteria. AI models exhibited strong performance with a pooled sensitivity of 0.84 (95% CI 0.80-0.88), specificity 0.87 (0.84- 0.91), PPV 0.90 (0.87-0.92), NPV 0.80 (0.71-0.88), observed agreement 0.85 (0.82- 0.89), and F1 score 0.85 (0.82-0.89). AI models demonstrated no significant differences with pathologists for specificity, observed agreement and F1 score, while they were outperformed by pathologists for sensitivity and NPV. AI models for the adult population were linked to reduced heterogeneity and enhanced AI performance at meta-regression., Conclusion: AI shows significant potential for assessing histological remission in UC and performs comparably to pathologists. Future research should focus on standardised, large-scale studies to minimise heterogeneity and support widespread AI implementation in clinical practice., (© The Author(s) 2025. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.)

Published
2025
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