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In his Mémoires, Saint-Simon gives details that make it possible for us to understand not only how foreigners were perceived, but also their place in the French court at the end of the seventeenth century. Analysis of the author’s semantics surrounding foreignness highlights a conception of the foreigner particular to the courtly world, with a basis more in the notion of sovereignty than on that of origin. Foreigners were most often found in the person of visiting diplomats or princes, who though included in the court’s ceremonial, occupied a marginal position, embodied in court etiquette. In contrast, service for men and marriage for princesses triggered an informal naturalization process for such foreigners living in France, made complete by their internalization of the court’s codes. In this way, Saint-Simon placed the integration of foreigners within a dynamic specific to court society, with as a consequence, the suppression of characteristics seen as foreign and the affirmation of a cosmopolitanism based on a European court identity.

School belonging, sometimes referred to as school belonging or school connectedness, involves dimensions like positive affect towards school, relationships with teachers, and feeling socially valued. Previous research points to immediate benefits for students' mental health and wellbeing; however, evidence on the potential long-term benefits of school belonging for mental health--once young people leave the school setting--is limited. This study used data on 1568 adults from the Australian Temperament Project (ATP), a 16-wave longitudinal study which has tracked participants since infancy. The short form of the Australian Council for Educational Research (ACER) School Life Questionnaire was used to assess secondary school belonging at age 15-16 years whilst young adult mental health symptoms were evaluated using the Depression, Anxiety and Stress Scales (DASS-21) at 19-20, 23-24, and 27-28 years. Generalised Estimating Equation models were used to examine the link between secondary school belonging and mental health symptoms in young adulthood. Results showed that higher levels of all aspects of school belonging were associated with lower mental health symptoms across young adulthood ([beta] range - 0.05 to - 0.20). Associations were similar by gender. These findings underscore the importance of adolescent school belonging and in particular school status in reference to feeling socially valued, as a long-term protective factor that can mitigate against later depression, anxiety, and stress.

Climate change is a complex, multisystem phenomenon that disrupts human development both directly and indirectly through the interactions of interconnected systems. This article outlines the physical, social, and psychological impacts of exposure to climate disasters, which are already increasing in frequency and ferocity across the globe. Climate change poses particular challenges for billions of people with vulnerabilities related to geography, age, injustice, poverty, and many other social or economic disadvantages. In this article, we apply resilience and positive development frameworks to describe the resources and processes at the level of the individual, the family, and the community that can prepare and support people as they contend with the impacts of climate change. To illustrate these frameworks in action, we give examples of promising interventions that focus on mobilizing powerful human adaptive systems to build hope, agency, social cohesion, and a shared sense of belonging. We conclude by calling on developmental scientists to engage in research, interventions, and collaborative advocacy to address the unprecedented and existential threat posed by climate change.

We performed a bioinformatics study to predict and compare the structural and functional properties of human caveolins: caveolin-1, -2 and -3. The computed local physico-chemical properties, predictions of their secondary structure elements and interacting partners of caveolin-2 and -3 are compared to experimentally proved structural and functional properties of caveolin-1. These data combined with the sequences alignment of the three caveolins, allowed predicting and characterizing the functional domains of caveolin-2 and -3. The hydrophobic regions of these proteins are highly similar in sequences and physicochemical properties and it is in good agreement with their known membrane locations and functions. The most divergent in sequences and properties are the C-terminal regions of caveolins suggesting that they might be responsible for their distinct predicted interactions, with direct consequences on signalling processes.

Background: This study compares dexmedetomidine and buprenorphine as potential adjuvants for spinal anesthesia. Dexmedetomidine enhances sensory block and minimizes the need for pain medication, while buprenorphine, a long-acting opioid, exhibits a favorable safety profile compared to traditional opioids. Methods: PubMed, Cochrane and EMBASE were systematically searched in December 2023. Eligibility criteria: RCTs with patients scheduled for lower abdominal, pelvic, or lower limb surgeries; undergoing spinal anesthesia with a local anesthetic and buprenorphine or dexmedetomidine. Results: Eight RCTs involving 604 patients were included. Compared with dexmedetomidine, buprenorphine significantly reduced time for sensory regression to S1 (Risk Ratio [RR = -131.28]; 95% CI -187.47 to -75.08; I2 = 99%) and motor block duration (RR = -118.58; 95% CI -170.08 to -67.09; I2 = 99%). Moreover, buprenorphine increased the onset time of sensory block (RR = 0.42; 95% CI 0.03 to 0.81; I2 = 93%) and increased the incidence of postoperative nausea and vomiting (RR = 4.06; 95% CI 1.80 to 9.18; I² = 0%). No significant differences were observed in the duration of analgesia, onset time of motor block, time to achieve the highest sensory level, shivering, hypotension, or bradycardia. Conclusions: The intrathecal administration of buprenorphine, when compared to dexmedetomidine, is linked to reduction in the duration of both sensory and motor blocks following spinal anesthesia. Conversely, buprenorphine was associated with an increased risk of postoperative nausea and vomiting and a longer onset time of sensory block. Further high-quality RCTs are essential for a comprehensive understanding of buprenorphine's effects compared with dexmedetomidine in spinal anesthesia.

ABSTRACT The factors and their levels influencing the seed germination process are well-known for most traditional forest species. But, for Jacaranda micrantha, a native and aesthetically appealing species, some factors influencing the germination process are not well described. So, we evaluated the effect of different light conditions and soaking on the germination of seeds. Four light intensity treatments (5, 25, 50, and 100%) and four soaking times were tested (0, 12, 24 and 48 hours). In both procedures, a completely randomized design was applied, with four treatments of four replicates containing 25 seeds each. Daily evaluations were performed to determine the germination percentage and the germination speed index (IVG). Seeds of J. micrantha presented a better germinative potential in lower light intensities, but more abnormal seedlings were observed at very low-intensity light (5%). The imbibition of seeds was efficient in accelerating the germination process, and the 12-hour soaking time in the water was the most efficient, contrary to what is described in the literature.

Introduction: Nursing care, despite constituting a significant portion of healthcare costs, often remains overlooked in healthcare data systems, which primarily focus on medical data. Incorporating standardized nursing language (SNL) into electronic health records has shown promise in predicting outcomes across various clinical settings. However, nurses' unfamiliarity with standardized terminologies poses a significant barrier to their implementation. NANDA-International (NANDA-I) nursing diagnoses (NDs) offer a standardized framework, yet their application in mental health (MH) settings remains underexplored. Objectives: The MINDSET study aims to establish a consensus among mental health nurses to develop a subset of nursing diagnoses tailored for MH and addiction EHRs. Methods: A multi-phase e-Delphi study will involve mental health nurses experienced in NANDA-I NDs from various countries. Through successive rounds of surveys, experts will assess the relevance of NDs in MH settings, with consensus determining the final subset. Results: The expected outcome is a concise subset of nursing diagnoses agreed upon by experts, facilitating their integration into clinical practice. This subset may offer nurses a manageable set of diagnoses closely aligned with MH contexts, enhancing their applicability and utility in daily care. Subsequent research could explore the prevalence of these diagnoses in MH settings and their associations with patient outcomes. Impact: The development of a tailored subset of nursing diagnoses holds potential to enhance nursing practice in MH settings, enabling more effective assessment and intervention strategies, ultimately improving patient outcomes.

Non-Hodgkin lymphomas (NHL) commonly occur in immune-deficient (ID) patients, both HIV-infected and transplanted, and are often EBV-driven with cerebral localization, raising the question of tumor immunogenicity, a critical issue for treatment responses. We investigated the immunogenomics of 68 lymphoproliferative disorders from 51 ID (34 posttransplant, 17 HIV+) and 17 immunocompetent patients. Overall, 72% were Large B Cells Lymphoma (LBCL) and 25% were primary central-nervous-system lymphoma (PCNSL) while 40% were EBV-positive. Tumor whole-exome and RNA sequencing, along with a bioinformatics pipeline allowed analysis of tumor mutational burden (TMB), tumor landscape and microenvironment (TME) and prediction of tumor neoepitopes. Both TMB (2.2 vs 3.4/Mb, p=0.001) and neoepitopes numbers (40 vs 200, p=0.00019) were lower in EBVpositive than in EBV-negative NHL, regardless of the immune status. In contrast both EBV and the immune status influenced the tumor mutational profile, with HNRNPF and STAT3 mutations exclusively observed in EBV-positive and ID NHL, respectively. Peripheral blood T-cell responses against tumor neoepitopes were detected in all EBV-negative cases but in only half EBV-positive ones, including responses against IgH-derived MHC-class-II restricted neoepitopes. The TME analysis showed higher CD8 T cell infiltrates in EBVpositive vs EBV-negative NHL, together with a more tolerogenic profile composed of Tregs, type-M2 macrophages and an increased expression of negative immune-regulators. Our results highlight that the immunogenomics of NHL in patients with immunodeficiency primarily relies on the tumor EBV status, while T cell recognition of tumor- and IgH-specific neoepitopes is conserved in EBV-negative patients, offering potential opportunities for future T cell-based immune therapies.