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1,338 results on '"Sanson, Marc"'

1. Epigenetic landscape reorganisation and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma

Author

Ghisai, Santoesha A., van Hijfte, Levi, Vallentgoed, Wies R., Tesileanu, C. Mircea S., de Heer, Iris, Kros, Johan M., Sanson, Marc, Gorlia, Thierry, Wick, Wolfgang, Vogelbaum, Michael A., Brandes, Alba A., Franceschi, Enrico, Clement, Paul M., Nowak, Anna K., Golfinopoulos, Vassilis, van den Bent, Martin J., French, Pim J., and Hoogstrate, Youri

Published
2024
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2. A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation

Author

Auffret, Lucie, Ajlil, Yassine, Tauziède-Espariat, Arnault, Kergrohen, Thomas, Puiseux, Chloé, Riffaud, Laurent, Blouin, Pascale, Bertozzi, Anne-Isabelle, Leblond, Pierre, Blomgren, Klas, Froelich, Sébastien, Picca, Alberto, Touat, Mehdi, Sanson, Marc, Beccaria, Kévin, Blauwblomme, Thomas, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Varlet, Pascale, Debily, Marie-Anne, Grill, Jacques, and Castel, David

Published
2024
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4. Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations

Author

Roberts, Holly J., Ji, Sunjong, Picca, Alberto, Sanson, Marc, Garcia, Mekka, Snuderl, Matija, Schüller, Ulrich, Picart, Thiébaud, Ducray, François, Green, Adam L., Nakano, Yoshiko, Sturm, Dominik, Abdullaev, Zied, Aldape, Kenneth, Dang, Derek, Kumar-Sinha, Chandan, Wu, Yi-Mi, Robinson, Dan, Vo, Josh N., Chinnaiyan, Arul M., Cartaxo, Rodrigo, Upadhyaya, Santhosh A., Mody, Rajen, Chiang, Jason, Baker, Suzanne, Solomon, David, Venneti, Sriram, Pratt, Drew, Waszak, Sebastian M., and Koschmann, Carl

Published
2023
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6. Integrated proteogenomic characterization of glioblastoma evolution

Author

Kim, Kyung-Hee, Migliozzi, Simona, Koo, Harim, Hong, Jun-Hee, Park, Seung Min, Kim, Sooheon, Kwon, Hyung Joon, Ha, Seokjun, Garofano, Luciano, Oh, Young Taek, D'Angelo, Fulvio, Kim, Chan Il, Kim, Seongsoo, Lee, Ji Yoon, Kim, Jiwon, Hong, Jisoo, Jang, Eun-Hae, Mathon, Bertrand, Di Stefano, Anna-Luisa, Bielle, Franck, Laurenge, Alice, Nesvizhskii, Alexey I., Hur, Eun-Mi, Yin, Jinlong, Shi, Bingyang, Kim, Youngwook, Moon, Kyung-Sub, Kwon, Jeong Taik, Lee, Shin Heon, Lee, Seung Hoon, Gwak, Ho Shin, Lasorella, Anna, Yoo, Heon, Sanson, Marc, Sa, Jason K., Park, Chul-Kee, Nam, Do-Hyun, Iavarone, Antonio, and Park, Jong Bae

Published
2024
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7. Futibatinib, an Irreversible FGFR1–4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF/FGFR Aberrations: A Phase I Dose-Expansion Study

Author

Meric-Bernstam, Funda, Bahleda, Rastislav, Hierro, Cinta, Sanson, Marc, Bridgewater, John, Arkenau, Hendrik-Tobias, Tran, Ben, Kelley, Robin Kate, Park, Joon Oh, Javle, Milind, He, Yaohua, Benhadji, Karim A, and Goyal, Lipika

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Cancer, Breast Cancer, Prevention, Clinical Research, Digestive Diseases, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Antineoplastic Agents, Bile Duct Neoplasms, Cholangiocarcinoma, Disease-Free Survival, Female, Humans, Male, Maximum Tolerated Dose, Middle Aged, Pyrazoles, Pyrimidines, Pyrroles, Receptor, Fibroblast Growth Factor, Type 1, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Futibatinib, a highly selective, irreversible FGFR1-4 inhibitor, was evaluated in a large multihistology phase I dose-expansion trial that enrolled 197 patients with advanced solid tumors. Futibatinib demonstrated an objective response rate (ORR) of 13.7%, with responses in a broad spectrum of tumors (cholangiocarcinoma and gastric, urothelial, central nervous system, head and neck, and breast cancer) bearing both known and previously uncharacterized FGFR1-3 aberrations. The greatest activity was observed in FGFR2 fusion/rearrangement-positive intrahepatic cholangiocarcinoma (ORR, 25.4%). Some patients with acquired resistance to a prior FGFR inhibitor also experienced responses with futibatinib. Futibatinib demonstrated a manageable safety profile. The most common treatment-emergent adverse events were hyperphosphatemia (81.2%), diarrhea (33.5%), and nausea (30.4%). These results formed the basis for ongoing futibatinib phase II/III trials and demonstrate the potential of genomically selected early-phase trials to help identify molecular subsets likely to benefit from targeted therapy. SIGNIFICANCE: This phase I dose-expansion trial demonstrated clinical activity and tolerability of the irreversible FGFR1-4 inhibitor futibatinib across a broad spectrum of FGFR-aberrant tumors. These results formed the rationale for ongoing phase II/III futibatinib trials in cholangiocarcinoma, breast cancer, gastroesophageal cancer, and a genomically selected disease-agnostic population.This article is highlighted in the In This Issue feature, p. 275.

Published
2022

8. An AI-powered blood test to detect cancer using nanoDSF

Author

Tsvetkov, Philipp O., Eyraud, Rémi, Ayache, Stéphane, Bougaev, Anton A., Malesinski, Soazig, Benazha, Hamed, Gorokhova, Svetlana, Buffat, Christophe, Dehais, Caroline, Sanson, Marc, Bielle, Franck, Figarella-Branger, Dominique, Chinot, Olivier, Tabouret, Emeline, and Devred, François

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Machine Learning, Quantitative Biology - Tissues and Organs
Abstract

We describe a novel cancer diagnostic method based on plasma denaturation profiles obtained by a non-conventional use of Differential Scanning Fluorimetry. We show that 84 glioma patients and 63 healthy controls can be automatically classified using denaturation profiles with the help of machine learning algorithms with 92% accuracy. Proposed high throughput workflow can be applied to any type of cancer and could become a powerful pan-cancer diagnostic and monitoring tool from a simple blood test.

Published
2020

10. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Author

Wen, Patrick Y, Weller, Michael, Lee, Eudocia Quant, Alexander, Brian M, Barnholtz-Sloan, Jill S, Barthel, Floris P, Batchelor, Tracy T, Bindra, Ranjit S, Chang, Susan M, Chiocca, E Antonio, Cloughesy, Timothy F, DeGroot, John F, Galanis, Evanthia, Gilbert, Mark R, Hegi, Monika E, Horbinski, Craig, Huang, Raymond Y, Lassman, Andrew B, Le Rhun, Emilie, Lim, Michael, Mehta, Minesh P, Mellinghoff, Ingo K, Minniti, Giuseppe, Nathanson, David, Platten, Michael, Preusser, Matthias, Roth, Patrick, Sanson, Marc, Schiff, David, Short, Susan C, Taphoorn, Martin JB, Tonn, Joerg-Christian, Tsang, Jonathan, Verhaak, Roel GW, von Deimling, Andreas, Wick, Wolfgang, Zadeh, Gelareh, Reardon, David A, Aldape, Kenneth D, and van den Bent, Martin J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Neurosciences, Rare Diseases, Cancer, Orphan Drug, Brain Cancer, Brain Disorders, 2.1 Biological and endogenous factors, Good Health and Well Being, Brain Neoplasms, Chemoradiotherapy, Clinical Trials, Phase III as Topic, Consensus, Glioblastoma, Humans, Isocitrate Dehydrogenase, Randomized Controlled Trials as Topic, glioblastoma, diagnosis, therapy, clinical trials, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Published
2020

11. Transcriptome analysis reveals tumor microenvironment changes in glioblastoma

Author

Hoogstrate, Youri, Draaisma, Kaspar, Ghisai, Santoesha A., van Hijfte, Levi, Barin, Nastaran, de Heer, Iris, Coppieters, Wouter, van den Bosch, Thierry P.P., Bolleboom, Anne, Gao, Zhenyu, Vincent, Arnaud J.P.E., Karim, Latifa, Deckers, Manon, Taphoorn, Martin J.B., Kerkhof, Melissa, Weyerbrock, Astrid, Sanson, Marc, Hoeben, Ann, Lukacova, Slávka, Lombardi, Giuseppe, Leenstra, Sieger, Hanse, Monique, Fleischeuer, Ruth E.M., Watts, Colin, Angelopoulos, Nicos, Gorlia, Thierry, Golfinopoulos, Vassilis, Bours, Vincent, van den Bent, Martin J., Robe, Pierre A., and French, Pim J.

Published
2023
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12. Challenges in glioblastoma research: focus on the tumor microenvironment

Author

Bikfalvi, Andreas, da Costa, Cristine Alves, Avril, Tony, Barnier, Jean-Vianney, Bauchet, Luc, Brisson, Lucie, Cartron, Pierre Francois, Castel, Hélène, Chevet, Eric, Chneiweiss, Hervé, Clavreul, Anne, Constantin, Bruno, Coronas, Valérie, Daubon, Thomas, Dontenwill, Monique, Ducray, Francois, Entz-Werlé, Natacha, Figarella-Branger, Dominique, Fournier, Isabelle, Frenel, Jean-Sébastien, Gabut, Mathieu, Galli, Thierry, Gavard, Julie, Huberfeld, Gilles, Hugnot, Jean-Philippe, Idbaih, Ahmed, Junier, Marie-Pierre, Mathivet, Thomas, Menei, Philippe, Meyronet, David, Mirjolet, Céline, Morin, Fabrice, Mosser, Jean, Moyal, Elisabeth Cohen-Jonathan, Rousseau, Véronique, Salzet, Michel, Sanson, Marc, Seano, Giorgio, Tabouret, Emeline, Tchoghandjian, Aurélie, Turchi, Laurent, Vallette, Francois M., Vats, Somya, Verreault, Maité, and Virolle, Thierry

Published
2023
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13. Epstein-Barr Virus and immune status imprint the immunogenomics of non-Hodgkin lymphomas occurring in immune-suppressed environments

Author

Baron, Marine, primary, Labreche, Karim, additional, Veyri, Marianne, additional, Désiré, Nathalie, additional, Bouzidi, Amira, additional, Seck-Thiam, Fatou, additional, Charlotte, Frédéric, additional, Rousseau, Alice, additional, Morin, Véronique, additional, Nakid-Cordero, Cécilia, additional, Abbar, Baptiste, additional, Picca, Alberto, additional, Le Cann, Marie, additional, Balegroune, Noureddine, additional, Gauthier, Nicolas, additional, Theodorou, Ioannis, additional, Touat, Mehdi, additional, Morel, Véronique, additional, Bielle, Franck, additional, Samri, Assia, additional, Alentorn, Agusti, additional, Sanson, Marc, additional, Roos-Weil, Damien, additional, Haioun, Corinne, additional, Poullot, Elsa, additional, De Septenville, Anne Langlois, additional, Davi, Frédéric, additional, Guihot, Amélie, additional, Boelle, Pierre-Yves, additional, Leblond, Véronique, additional, Coulet, Florence, additional, Spano, Jean-Philippe, additional, Choquet, Sylvain, additional, Autran, Brigitte, additional, and Study group, IDeATIon, additional

Published
2024
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16. Neuro-Psychological Outcome of ICU-Admitted COVID-19 Patients Presenting With CNS Complications

Author

Pelle, Juliette, Nedelec, Thomas, Marois, Clémence, Delorme, Cecile, Corvol, Jean-Christophe, Delattre, Jean-Yves, Carvalho, Stephanie, Sagnes, Sandrine, Dubois, Bruno, Navarro, Vincent, Louapre, Celine, Stojkovic, Tanya, Idbaih, Ahmed, Rosso, Charlotte, Grabli, David, Gales, Ana Zenovia, Millet, Bruno, Rohaut, Benjamin, Bayen, Eleonore, Dupont, Sophie, Bruneteau, Gaelle, Lehericy, Stephane, Seilhean, Danielle, Durr, Alexandra, Lamari, Foudil, Houot, Marion, Brochard, Vanessa Batista, Lubetzki, Catherine, Seilhean, Danielle, Pradat-Diehl, Pascale, Rosso, Charlotte, Hoang-Xuan, Khe, Fontaine, Bertrand, Naccache, Lionel, Fossati, Philippe, Arnulf, Isabelle, Durr, Alexandra, Carpentier, Alexandre, Edel, Yves, Robain, Gilberte, Thoumie, Philippe, Degos, Bertrand, Sharshar, Tarek, Alamowitch, Sonia, Apartis-Bourdieu, Emmanuelle, Peretti, Charles-Siegried, Ursu, Renata, Dzierzynski, Nathalie, Bourron, Kiyoka Kinugawa, Belmin, Joel, Oquendo, Bruno, Pautas, Eric, Verny, Marc, Samson, Yves, Leder, Sara, Leger, Anne, Deltour, Sandrine, Baronnet, Flore, Bombois, Stephanie, Touat, Mehdi, Idbaih, Ahmed, Sanson, Marc, Dehais, Caroline, Houillier, Caroline, Laigle-Donadey, Florence, Psimaras, Dimitri, Alenton, Agusti, Younan, Nadia, Villain, Nicolas, Grabli, David, del Mar Amador, Maria, Bruneteau, Gaelle, Louapre, Celine, Mariani, Louise-Laure, Mezouar, Nicolas, Mangone, Graziella, Meneret, Aurelie, Hartmann, Andreas, Tarrano, Clement, Bendetowicz, David, Pradat, Pierre-François, Baulac, Michel, Sambin, Sara, Pichit, Phintip, Chochon, Florence, Hesters, Adele, Herlin, Bastien, Nguyen, An Hung, Procher, Valerie, Demoule, Alexandre, Morawiec, Elise, Mayaux, Julien, Faure, Morgan, Ewenczyk, Claire, Coarelli, Giulia, Heinzmann, Anna, Stojkovic, Tanya, Masingue, Marion, Bassez, Guillaume, Navarro, Vincent, An, Isabelle, Worbe, Yulia, Lambrecq, Virginie, Debs, Rabab, Musat, Esteban Munoz, Lenglet, Timothee, Lambrecq, Virginie, Hanin, Aurelie, Chougar, Lydia, Shor, Nathalia, Pyatigorskaya, Nadya, Galanaud, Damien, Leclercq, Delphine, Demeret, Sophie, Rohaut, Benjamin, Cao, Albert, Marois, Clemence, Weiss, Nicolas, Gassama, Salimata, Guennec, Loic Le, Degos, Vincent, Jacquens, Alice, Similowski, Thomas, Morelot-Panzini, Capucine, Rotge, Jean-Yves, Saudreau, Bertrand, Millet, Bruno, Pitron, Victor, Sarni, Nassim, Girault, Nathalie, Maatoug, Redwan, Leu, Smaranda, Bayen, Eleonore, Thivard, Lionel, Mokhtari, Karima, Plu, Isabelle, Gonçalves, Bruno, Bottin, Laure, Yger, Marion, Ouvrard, Gaelle, Haddad, Rebecca, Ketz, Flora, Lafuente, Carmelo, Oasi, Christel, Megabarne, Bruno, Herve, Dominique, Salman, Haysam, Rametti-Lacroux, Armelle, Chalançon, Alize, Herve, Anais, Royer, Hugo, Beauzor, Florence, Maheo, Valentine, Laganot, Christelle, Minelli, Camille, Fekete, Aurelie, Grine, Abel, Biet, Marie, Hilab, Rania, Besnard, Aurore, Bouguerra, Meriem, Goudard, Gwen, Houairi, Saida, Al-Youssef, Saba, Pires, Christine, Oukhedouma, Anissa, Siuda-Krzywicka, Katarzyna, Malkinson, Tal Seidel, Agguini, Hanane, Said, Safia, and Houot, Marion

Published
2023
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18. Mendelian randomisation study of the relationship between vitamin D and risk of glioma.

Author

Takahashi, Hannah, Cornish, Alex J, Sud, Amit, Law, Philip J, Kinnersley, Ben, Ostrom, Quinn T, Labreche, Karim, Eckel-Passow, Jeanette E, Armstrong, Georgina N, Claus, Elizabeth B, Il'yasova, Dora, Schildkraut, Joellen, Barnholtz-Sloan, Jill S, Olson, Sara H, Bernstein, Jonine L, Lai, Rose K, Schoemaker, Minouk J, Simon, Matthias, Hoffmann, Per, Nöthen, Markus M, Jöckel, Karl-Heinz, Chanock, Stephen, Rajaraman, Preetha, Johansen, Christoffer, Jenkins, Robert B, Melin, Beatrice S, Wrensch, Margaret R, Sanson, Marc, Bondy, Melissa L, Turnbull, Clare, and Houlston, Richard S

Subjects
Humans, Glioma, Brain Neoplasms, Genetic Predisposition to Disease, Vitamin D, Polymorphism, Single Nucleotide, Genetic Variation, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide
Abstract

To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D levels were used as instrumental variables (IVs). We calculated MR estimates for the odds ratio (OR) for 25(OH)D levels with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighted (IVW) and maximum likelihood estimation (MLE) methods. A non-significant association between 25(OH)D levels and glioma risk was shown using both the IVW (OR = 1.21, 95% confidence interval [CI] = 0.90-1.62, P = 0.201) and MLE (OR = 1.20, 95% CI = 0.98-1.48, P = 0.083) methods. In an exploratory analysis of tumour subtype, an inverse relationship between 25(OH)D levels and glioblastoma (GBM) risk was identified using the MLE method (OR = 0.62, 95% CI = 0.43-0.89, P = 0.010), but not the IVW method (OR = 0.62, 95% CI = 0.37-1.04, P = 0.070). No statistically significant association was shown between 25(OH)D levels and non-GBM glioma. Our results do not provide evidence for a causal relationship between 25(OH)D levels and all forms of glioma risk. More evidence is required to explore the relationship between 25(OH)D levels and risk of GBM.

Published
2018

19. Epigenetic landscape reorganization and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma

Author

Ghisai, Santoesha A, primary, van Hijfte, Levi, additional, Vallentgoed, Wies R, additional, Tesileanu, C Mircea S, additional, de Heer, Iris, additional, Kros, Johan M, additional, Sanson, Marc, additional, Gorlia, Thierry, additional, Wick, Wolfgang, additional, Vogelbaum, Michael A, additional, Brandes, Alba A, additional, Franceschi, Enrico, additional, Clement, Paul M, additional, Nowak, Anna K, additional, Golfinopoulos, Vassilis, additional, van den Bent, Martin J, additional, French, Pim J, additional, and Hoogstrate, Youri, additional

Published
2024
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20. Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

Author

Vallentgoed, Wies R., primary, Hoogstrate, Youri, additional, van Garderen, Karin A., additional, van Hijfte, Levi, additional, van Dijk, Erik, additional, Kouwenhoven, Mathilde C. M., additional, Niers, Johanna M., additional, Draaisma, Kaspar, additional, Martin, Ivonne, additional, de Leng, Wendy W. J., additional, Tesileanu, C. Mircea S., additional, de Heer, Iris, additional, Diepeveen, Maud, additional, Lavrova, Anna, additional, Eijk, Paul P., additional, Bühler, Marcel, additional, Wick, Wolfgang, additional, Clement, Paul M., additional, Sanson, Marc, additional, Franceschi, Enrico, additional, Gorlia, Thierry, additional, Golfinopoulos, Vassilis, additional, Weller, Michael, additional, Weiss, Tobias, additional, Robe, Pierre A., additional, Kros, Johan M., additional, Smits, Marion, additional, van de Wiel, Mark, additional, Ylstra, Bauke, additional, Verhaak, Roel G. W., additional, van den Bent, Martin J., additional, Westerman, Bart A., additional, Wesseling, Pieter, additional, and French, Pim J., additional

Published
2024
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21. Automated Acquisition Planning for Magnetic Resonance Spectroscopy in Brain Cancer

Author

Bolan, Patrick J., Branzoli, Francesca, Di Stefano, Anna Luisa, Nichelli, Lucia, Valabregue, Romain, Saunders, Sara L., Akçakaya, Mehmet, Sanson, Marc, Lehéricy, Stéphane, Marjańska, Małgorzata, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Martel, Anne L., editor, Abolmaesumi, Purang, editor, Stoyanov, Danail, editor, Mateus, Diana, editor, Zuluaga, Maria A., editor, Zhou, S. Kevin, editor, Racoceanu, Daniel, editor, and Joskowicz, Leo, editor

Published
2020
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23. Mismatch Repair Deficiency and Lynch Syndrome Among Adult Patients With Glioma

Author

Benusiglio, Patrick R., Elder, Fikret, Touat, Mehdi, Perrier, Alexandre, Sanson, Marc, Colas, Chrystelle, Guerrini-Rousseau, Lea, Tran, Duy Thanh, Trabelsi, Nesrine, Carpentier, Catherine, Marie, Yannick, Adam, Clovis, Bernier, Michèle, Cazals-Hatem, Dominique, Mokhtari, Karima, Tran, Suzanne, Mathon, Bertrand, Capelle, Laurent, Dhooge, Marion, Idbaih, Ahmed, Alentorn, Agusti, Houillier, Caroline, Dehais, Caroline, Hoang-Xuan, Khe, Cuzzubbo, Stefania, Carpentier, Antoine, Duval, Alex, Coulet, Florence, and Bielle, Franck

Published
2023
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24. Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study

Author

van den Bent, Martin J, Tesileanu, C Mircea S, Wick, Wolfgang, Sanson, Marc, Brandes, Alba Ariela, Clement, Paul M, Erridge, Sarah, Vogelbaum, Michael A, Nowak, Anna K, Baurain, Jean Français, Mason, Warren P, Wheeler, Helen, Chinot, Olivier L, Gill, Sanjeev, Griffin, Matthew, Rogers, Leland, Taal, Walter, Rudà, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H, Caparrotti, Francesca, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Lim, Elizabeth, Herrlinger, Ulrich, Hau, Peter, Dhermain, Frederic, de Heer, Iris, Aldape, Kenneth, Jenkins, Robert B, Dubbink, Hendrikus Jan, Kros, Johan M, Wesseling, Pieter, Nuyens, Sarah, Golfinopoulos, Vassilis, Gorlia, Thierry, French, Pim, and Baumert, Brigitta G

Published
2021
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25. Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Author

Melin, Beatrice S, Barnholtz-Sloan, Jill S, Wrensch, Margaret R, Johansen, Christoffer, Il'yasova, Dora, Kinnersley, Ben, Ostrom, Quinn T, Labreche, Karim, Chen, Yanwen, Armstrong, Georgina, Liu, Yanhong, Eckel-Passow, Jeanette E, Decker, Paul A, Labussière, Marianne, Idbaih, Ahmed, Hoang-Xuan, Khe, Di Stefano, Anna-Luisa, Mokhtari, Karima, Delattre, Jean-Yves, Broderick, Peter, Galan, Pilar, Gousias, Konstantinos, Schramm, Johannes, Schoemaker, Minouk J, Fleming, Sarah J, Herms, Stefan, Heilmann, Stefanie, Nöthen, Markus M, Wichmann, Heinz-Erich, Schreiber, Stefan, Swerdlow, Anthony, Lathrop, Mark, Simon, Matthias, Sanson, Marc, Andersson, Ulrika, Rajaraman, Preetha, Chanock, Stephen, Linet, Martha, Wang, Zhaoming, Yeager, Meredith, Wiencke, John K, Hansen, Helen, McCoy, Lucie, Rice, Terri, Kosel, Matthew L, Sicotte, Hugues, Amos, Christopher I, Bernstein, Jonine L, Davis, Faith, Lachance, Dan, Lau, Ching, Merrell, Ryan T, Shildkraut, Joellen, Ali-Osman, Francis, Sadetzki, Siegal, Scheurer, Michael, Shete, Sanjay, Lai, Rose K, Claus, Elizabeth B, Olson, Sara H, Jenkins, Robert B, Houlston, Richard S, and Bondy, Melissa L

Subjects
Biological Sciences, Genetics, Rare Diseases, Human Genome, Brain Disorders, Cancer, Neurosciences, Prevention, Brain Cancer, Alleles, Brain Neoplasms, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Glioblastoma, Glioma, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Quantitative Trait Loci, GliomaScan Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10-9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10-10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10-11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10-10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10-9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10-10, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10-10, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10-9, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10-10, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10-11, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10-9, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

Published
2017

26. Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations

Author

Tesileanu, C. Mircea S., Vallentgoed, Wies R., Sanson, Marc, Taal, Walter, Clement, Paul M., Wick, Wolfgang, Brandes, Alba Ariela, Baurain, Jean Francais, Chinot, Olivier L., Wheeler, Helen, Gill, Sanjeev, Griffin, Matthew, Rogers, Leland, Rudà, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H., Caparrotti, Francesca, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Lim, Elizabeth, de Vos, Filip, Mulholland, Paul J., Taphoorn, Martin J. B., de Heer, Iris, Hoogstrate, Youri, de Wit, Maurice, Boggiani, Lorenzo, Venneker, Sanne, Oosting, Jan, Bovée, Judith V. M. G., Erridge, Sara, Vogelbaum, Michael A., Nowak, Anna K., Mason, Warren P., Kros, Johan M., Wesseling, Pieter, Aldape, Ken, Jenkins, Robert B., Dubbink, Hendrikus J., Baumert, Brigitta, Golfinopoulos, Vassilis, Gorlia, Thierry, van den Bent, Martin, and French, Pim J.

Published
2021
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27. Multimodal management of surgery- and radiation-refractory meningiomas: an analysis of the French national tumor board meeting on meningiomas cohort

Author

Le Van, Tuan, Graillon, Thomas, Jacob, Julian, Vauleon, Elodie, Feuvret, Loic, Boch, Anne-Laure, Boetto, Julien, Boone, Mathieu, Bronnimann, Charlotte, Caire, François, De Barros, Amaury, Delaitre, Mariette, Di Stefano, Anna Luisa, Dore, Mélanie, Ducray, François, Dufour, Christelle, Engelhardt, Julien, Fontaine, Denys, Froelich, Sebastien, Helleringer, Matthieu, Huchet, Aymeri, Joncour, Anthony, Jouanneau, Emmanuel, Mallereau, Charles-Henry, Monfilliette, Apolline, Le Fur, Emmanuelle, Zemmoura, Ilyess, Chinot, Olivier, Sanson, Marc, Kalamarides, Michel, Loiseau, Hugues, and Peyre, Matthieu

Published
2021
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28. Initial surgical resection and long time to occurrence from initial diagnosis are independent prognostic factors in resected recurrent IDH wild-type glioblastoma

Author

Seyve, Antoine, Lozano-Sanchez, Fernando, Thomas, Alice, Mathon, Bertrand, Tran, Suzanne, Mokhtari, Karima, Giry, Marine, Marie, Yannick, Capelle, Laurent, Peyre, Matthieu, Carpentier, Alexandre, Feuvret, Loic, Sanson, Marc, Hoang-Xuan, Khê, Honnorat, Jérome, Delattre, Jean-Yves, Ducray, François, and Idbaih, Ahmed

Published
2020
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29. Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities

Author

Garofano, Luciano, Migliozzi, Simona, Oh, Young Taek, D’Angelo, Fulvio, Najac, Ryan D., Ko, Aram, Frangaj, Brulinda, Caruso, Francesca Pia, Yu, Kai, Yuan, Jinzhou, Zhao, Wenting, Di Stefano, Anna Luisa, Bielle, Franck, Jiang, Tao, Sims, Peter, Suvà, Mario L., Tang, Fuchou, Su, Xiao-Dong, Ceccarelli, Michele, Sanson, Marc, Lasorella, Anna, and Iavarone, Antonio

Published
2021
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30. A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation

Author

Auffret, Lucie, primary, Ajlil, Yassine, additional, Tauziède-Espariat, Arnault, additional, Kergrohen, Thomas, additional, Puiseux, Chloé, additional, Riffaud, Laurent, additional, Blouin, Pascale, additional, Bertozzi, Anne-Isabelle, additional, Leblond, Pierre, additional, Blomgren, Klas, additional, Froelich, Sébastien, additional, Picca, Alberto, additional, Touat, Mehdi, additional, Sanson, Marc, additional, Beccaria, Kévin, additional, Blauwblomme, Thomas, additional, Dangouloff-Ros, Volodia, additional, Boddaert, Nathalie, additional, Varlet, Pascale, additional, Debily, Marie-Anne, additional, Grill, Jacques, additional, and Castel, David, additional

Published
2023
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33. Mechanisms and therapeutic implications of hypermutation in gliomas

Author

Touat, Mehdi, Li, Yvonne Y., Boynton, Adam N., Spurr, Liam F., Iorgulescu, J. Bryan, Bohrson, Craig L., Cortes-Ciriano, Isidro, Birzu, Cristina, Geduldig, Jack E., Pelton, Kristine, Lim-Fat, Mary Jane, Pal, Sangita, Ferrer-Luna, Ruben, Ramkissoon, Shakti H., Dubois, Frank, Bellamy, Charlotte, Currimjee, Naomi, Bonardi, Juliana, Qian, Kenin, Ho, Patricia, Malinowski, Seth, Taquet, Leon, Jones, Robert E., Shetty, Aniket, Chow, Kin-Hoe, Sharaf, Radwa, Pavlick, Dean, Albacker, Lee A., Younan, Nadia, Baldini, Capucine, Verreault, Maïté, Giry, Marine, Guillerm, Erell, Ammari, Samy, Beuvon, Frédéric, Mokhtari, Karima, Alentorn, Agusti, Dehais, Caroline, Houillier, Caroline, Laigle-Donadey, Florence, Psimaras, Dimitri, Lee, Eudocia Q., Nayak, Lakshmi, McFaline-Figueroa, J. Ricardo, Carpentier, Alexandre, Cornu, Philippe, Capelle, Laurent, Mathon, Bertrand, Barnholtz-Sloan, Jill S., Chakravarti, Arnab, Bi, Wenya Linda, Chiocca, E. Antonio, Fehnel, Katie Pricola, Alexandrescu, Sanda, Chi, Susan N., Haas-Kogan, Daphne, Batchelor, Tracy T., Frampton, Garrett M., Alexander, Brian M., Huang, Raymond Y., Ligon, Azra H., Coulet, Florence, Delattre, Jean-Yves, Hoang-Xuan, Khê, Meredith, David M., Santagata, Sandro, Duval, Alex, Sanson, Marc, Cherniack, Andrew D., Wen, Patrick Y., Reardon, David A., Marabelle, Aurélien, Park, Peter J., Idbaih, Ahmed, Beroukhim, Rameen, Bandopadhayay, Pratiti, Bielle, Franck, and Ligon, Keith L.

Published
2020
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37. CSIG-24. LINEAR GRADING COEFFICIENT REVEALS EMBRYONIC DEVELOPMENT GENE SIGNATURE AS TREATMENT-INDEPENDENT PROGNOSTIC FACTOR IN IDH-MUTANT ASTROCYTOMA

Author

Ghisai, Santoesha, primary, Hoogstrate, Youri, additional, Tesileanu, Mircea, additional, van Hijfte, Levi, additional, Vallentgoed, Wies, additional, de Heer, Iris, additional, Preusser, Matthias, additional, Gorlia, Thierry, additional, Sanson, Marc, additional, van den Bent, Martin, additional, and French, Pim, additional

Published
2023
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38. CTNI-33. TARGET TRIAL: A PHASE I/II OPEN-LABEL MULTICENTER STUDY TO ASSESS SAFETY, TOLERABILITY, AND CLINICAL EFFICACY OF AZD4547 IN PATIENTS WITH RELAPSED/REFRACTORY FGFR FUSION POSITIVE GLIOMA

Author

Picca, Alberto, primary, Stefano, Anna Luisa Di, additional, Savatovsky, Julien, additional, Ducray, Francois, additional, Chinot, Olivier, additional, Moyal, Elisabeth Cohen-Jonathan, additional, Augereau, Paule, additional, Schmitt, Yohann, additional, Lerond, Julie, additional, Rousseaux, Nabila, additional, Fardeau, Christine, additional, Mokhtari, Karima, additional, Bielle, Franck, additional, Meyronet, David, additional, Iavarone, Antonio, additional, and Sanson, Marc, additional

Published
2023
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39. EXTH-59. IDENTIFICATION OF GROWTH HORMONE RECEPTOR AS A RELEVANT TARGET FOR PRECISION MEDICINE IN LOW-EGFR EXPRESSING GLIOBLASTOMA

Author

Verreault, Maite, primary, Vilchis, Irma Segoviano, additional, Rosenberg, Shai, additional, Lemaire, Nolwenn, additional, Schmitt, Charlotte, additional, Guehennec, Jeremy, additional, Royer-Perron, Louis, additional, Thomas, Jean-Leon, additional, Lam, Tukiet T, additional, Dingli, Florent, additional, Loew, Damarys, additional, Ducray, Francois, additional, Paris, Sophie, additional, Carpentier, Catherine, additional, Marie, Yannick, additional, Laigle-Donadey, Florence, additional, Rousseau, Audrey, additional, Pigat, Natascha, additional, Boutillon, Florence, additional, Bielle, Franck, additional, Mokhtari, Karima, additional, Frank, Stuart J, additional, de Reynies, Aurelien, additional, Hoang-Xuan, Khe, additional, Sanson, Marc, additional, Goffin, Vincent, additional, and Idbaih, Ahmed, additional

Published
2023
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40. EPCO-37. DISSECTING GBM EVOLUTION FOLLOWING STANDARD-OF-CARE BY LARGE-SCALE LONGITUDINAL SINGLE NUCLEUS RNA-SEQUENCING

Author

Nomura, Masashi, primary, Spitzer, Avishay, additional, Johnson, Kevin, additional, Garofano, Luciano, additional, Nehar-Belaid, Djamel, additional, Oh, Young Taek, additional, Anderson, Kevin J, additional, Najac, Ryan D, additional, Bussema, Lillian, additional, Varn, Frederick, additional, D’Angelo, Fulvio, additional, Chowdhury, Tamrin, additional, Migliozzi, Simona, additional, Park, Jong Bae, additional, Ermini, Luca, additional, Golebiewska, Anna, additional, Niclou, Simone, additional, Das, Sunit, additional, Paek, Sun Ha, additional, Moon, Hyo-Eun, additional, Mathon, Bertrand, additional, Stefano, Anna-Luisa Di, additional, Bielle, Franck, additional, Laurenge, Alice, additional, Sanson, Marc, additional, Tanaka, Shota, additional, Saito, Nobuhito, additional, Keir, Steve, additional, Ashley, David, additional, Huse, Jason, additional, Alfred Yung, W K, additional, Lasorella, Anna, additional, Iavarone, Antonio, additional, Verhaak, Roel, additional, Suva, Mario, additional, and Tirosh, Itay, additional

Published
2023
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41. EXTH-83. BIRC3 AS A PREDICTOR OF OUTCOME AND A NEW THERAPEUTIC TARGET IN TMZ RESISTANT GLIOBLASTOMA TUMORS

Author

Morelli, Mariangela, primary, Franceschi, Sara, additional, Lessi, Francesca, additional, Aretini, Paolo, additional, Pastore, Aldo, additional, Corradi, Elena, additional, Marranci, Andrea, additional, Gambacciani, Carlo, additional, Pieri, Francesco, additional, Grimod, Gianluca, additional, Montemurro, Nicola, additional, Giacomarra, Manuel, additional, Menicagli, Michele, additional, Ferri, Gianmarco, additional, Pasqualetti, Francesco, additional, Sanson, Marc, additional, Picca, Alberto, additional, Stefano, Anna Luisa Di, additional, Santonocito, Orazio Santo, additional, and Mazzanti, Chiara Maria, additional

Published
2023
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42. EPCO-09. CHARACTERIZING THE GBM CELLULAR LANDSCAPE BY LARGE-SCALE SINGLE-NUCLEUS RNA-SEQUENCING

Author

Spitzer, Avishay, primary, Nomura, Masashi, additional, Garofano, Luciano, additional, Johnson, Kevin, additional, Nehar-Belaid, Djamel, additional, Oh, Young Taek, additional, Anderson, Kevin J, additional, Najac, Ryan D, additional, Bussema, Lillian, additional, Varn, Frederick, additional, D’Angelo, Fulvio, additional, Chowdhury, Tamrin, additional, Migliozzi, Simona, additional, Park, Jong Bae, additional, Ermini, Luca, additional, Golebiewska, Anna, additional, Niclou, Simone, additional, Das, Sunit, additional, Paek, Sun Ha, additional, Moon, Hyo-Eun, additional, Mathon, Bertrand, additional, Stefano, Anna-Luisa Di, additional, Bielle, Franck, additional, Laurenge, Alice, additional, Sanson, Marc, additional, Tanaka, Shota, additional, Saito, Nobuhito, additional, Keir, Steve, additional, Ashley, David, additional, Huse, Jason, additional, Yung, W K Alfred, additional, Lasorella, Anna, additional, Verhaak, Roel, additional, Iavarone, Antonio, additional, Tirosh, Itay, additional, and Suva, Mario, additional

Published
2023
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47. Temporary blood–brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma

Author

Dréan, Antonin, Lemaire, Nolwenn, Bouchoux, Guillaume, Goldwirt, Lauriane, Canney, Michael, Goli, Larissa, Bouzidi, Amira, Schmitt, Charlotte, Guehennec, Jeremy, Verreault, Maïté, Sanson, Marc, Delattre, Jean-Yves, Mokhtari, Karima, Sottilini, Frédéric, Carpentier, Alexandre, and Idbaih, Ahmed

Published
2019
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48. The molecular landscape of glioma in patients with Neurofibromatosis 1

Author

D’Angelo, Fulvio, Ceccarelli, Michele, Tala, Garofano, Luciano, Zhang, Jing, Frattini, Véronique, Caruso, Francesca P., Lewis, Genevieve, Alfaro, Kristin D., Bauchet, Luc, Berzero, Giulia, Cachia, David, Cangiano, Mario, Capelle, Laurent, de Groot, John, DiMeco, Francesco, Ducray, François, Farah, Walid, Finocchiaro, Gaetano, Goutagny, Stéphane, Kamiya-Matsuoka, Carlos, Lavarino, Cinzia, Loiseau, Hugues, Lorgis, Véronique, Marras, Carlo E., McCutcheon, Ian, Nam, Do-Hyun, Ronchi, Susanna, Saletti, Veronica, Seizeur, Romuald, Slopis, John, Suñol, Mariona, Vandenbos, Fanny, Varlet, Pascale, Vidaud, Dominique, Watts, Colin, Tabar, Viviane, Reuss, David E., Kim, Seung-Ki, Meyronet, David, Mokhtari, Karima, Salvador, Hector, Bhat, Krishna P., Eoli, Marica, Sanson, Marc, Lasorella, Anna, and Iavarone, Antonio

Published
2019
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49. Genome-wide association study of glioma and meta-analysis

Author

Rajaraman, Preetha, Melin, Beatrice S, Wang, Zhaoming, McKean-Cowdin, Roberta, Michaud, Dominique S, Wang, Sophia S, Bondy, Melissa, Houlston, Richard, Jenkins, Robert B, Wrensch, Margaret, Yeager, Meredith, Ahlbom, Anders, Albanes, Demetrius, Andersson, Ulrika, Freeman, Laura E Beane, Buring, Julie E, Butler, Mary Ann, Braganza, Melissa, Carreon, Tania, Feychting, Maria, Fleming, Sarah J, Gapstur, Susan M, Gaziano, J Michael, Giles, Graham G, Hallmans, Goran, Henriksson, Roger, Hoffman-Bolton, Judith, Inskip, Peter D, Johansen, Christoffer, Kitahara, Cari M, Lathrop, Mark, Liu, Chenwei, Le Marchand, Loic, Linet, Martha S, Lonn, Stefan, Peters, Ulrike, Purdue, Mark P, Rothman, Nathaniel, Ruder, Avima M, Sanson, Marc, Sesso, Howard D, Severi, Gianluca, Shu, Xiao-Ou, Simon, Matthias, Stampfer, Meir, Stevens, Victoria L, Visvanathan, Kala, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Decker, Paul, Enciso-Mora, Victor, Fridley, Brooke, Gao, Yu-Tang, Kosel, Matthew, Lachance, Daniel H, Lau, Ching, Rice, Terri, Swerdlow, Anthony, Wiemels, Joseph L, Wiencke, John K, Shete, Sanjay, Xiang, Yong-Bing, Xiao, Yuanyuan, Hoover, Robert N, Fraumeni, Joseph F, Chatterjee, Nilanjan, Hartge, Patricia, and Chanock, Stephen J

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Clinical Research, Brain Disorders, Prevention, Brain Cancer, Neurosciences, Cancer, Human Genome, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Aged, Brain Neoplasms, Case-Control Studies, Cohort Studies, Cyclin-Dependent Kinase Inhibitor p15, DNA Helicases, Female, Genome-Wide Association Study, Glioblastoma, Glioma, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Telomerase, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity, Reproductive medicine
Abstract

Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk.

Published
2012

50. Leveraging Ethnic Group Incidence Variation to Investigate Genetic Susceptibility to Glioma: A Novel Candidate SNP Approach

Author

Jacobs, Daniel I, Walsh, Kyle M, Wrensch, Margaret, Wiencke, John, Jenkins, Robert, Houlston, Richard S, Bondy, Melissa, Simon, Matthias, Sanson, Marc, Gousias, Konstantinos, Schramm, Johannes, Labussière, Marianne, Di Stefano, Anna Luisa, Wichmann, H-Erich, Müller-Nurasyid, Martina, Schreiber, Stefan, Franke, Andre, Moebus, Susanne, Eisele, Lewin, Dewan, Andrew T, and Dubrow, Robert

Subjects
Biological Sciences, Genetics, Neurosciences, Brain Disorders, Human Genome, Clinical Research, Brain Cancer, Rare Diseases, Cancer, Aging, 2.1 Biological and endogenous factors, Aetiology, admixture, ancestry informative markers, brain cancer, candidate SNP association study, ethnicity, glioma, race, Clinical Sciences, Law
Abstract

ObjectivesUsing a novel candidate SNP approach, we aimed to identify a possible genetic basis for the higher glioma incidence in Whites relative to East Asians and African-Americans.Methods  We hypothesized that genetic regions containing SNPs with extreme differences in allele frequencies across ethnicities are most likely to harbor susceptibility variants. We used International HapMap Project data to identify 3,961 candidate SNPs with the largest allele frequency differences in Whites compared to East Asians and Africans and tested these SNPs for association with glioma risk in a set of White cases and controls. Top SNPs identified in the discovery dataset were tested for association with glioma in five independent replication datasets.ResultsNo SNP achieved statistical significance in either the discovery or replication datasets after accounting for multiple testing or conducting meta-analysis. However, the most strongly associated SNP, rs879471, was found to be in linkage disequilibrium with a previously identified risk SNP, rs6010620, in RTEL1. We estimate rs6010620 to account for a glioma incidence rate ratio of 1.34 for Whites relative to East Asians.ConclusionWe explored genetic susceptibility to glioma using a novel candidate SNP method which may be applicable to other diseases with appropriate epidemiologic patterns.

Published
2012

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