17,526 results on '"Sannino, A"'
Search Results
2. AMBER -- Advanced SegFormer for Multi-Band Image Segmentation: an application to Hyperspectral Imaging
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Dosi, Andrea, Brescia, Massimo, Cavuoti, Stefano, D'Aniello, Mariarca, Veneri, Michele Delli, Donadio, Carlo, Ettari, Adriano, Longo, Giuseppe, Rownok, Alvi, Sannino, Luca, and Zampella, Maria
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
Deep learning has revolutionized the field of hyperspectral image (HSI) analysis, enabling the extraction of complex and hierarchical features. While convolutional neural networks (CNNs) have been the backbone of HSI classification, their limitations in capturing global contextual features have led to the exploration of Vision Transformers (ViTs). This paper introduces AMBER, an advanced SegFormer specifically designed for multi-band image segmentation. AMBER enhances the original SegFormer by incorporating three-dimensional convolutions to handle hyperspectral data. Our experiments, conducted on the Indian Pines, Pavia University, and PRISMA datasets, show that AMBER outperforms traditional CNN-based methods in terms of Overall Accuracy, Kappa coefficient, and Average Accuracy on the first two datasets, and achieves state-of-the-art performance on the PRISMA dataset., Comment: submitted to Neural Computing & Applications (Springer). Currently under review
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- 2024
3. Exact Results for Scaling Dimensions of Neutral Operators in scalar CFTs
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Antipin, Oleg, Bersini, Jahmall, and Sannino, Francesco
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High Energy Physics - Theory ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We determine the scaling dimension $\Delta_n$ for the class of composite operators $\phi^n$ in the $\lambda \phi^4$ theory in $d=4-\epsilon$ taking the double scaling limit $n\rightarrow \infty$ and $\lambda \rightarrow 0$ with fixed $\lambda n$ via a semiclassical approach. Our results resum the leading power of $n$ at any loop order. In the small $\lambda n$ regime we reproduce the known diagrammatic results and predict the infinite series of higher-order terms. For intermediate values of $\lambda n$ we find that $\Delta_n/n$ increases monotonically approaching a $(\lambda n)^{1/3}$ behavior in the $\lambda n \to \infty$ limit. We further generalize our results to neutral operators in the $\phi^4$ in $d=4-\epsilon$, $\phi^3$ in $d=6-\epsilon$, and $\phi^6$ in $d=3-\epsilon$ theories with $O(N)$ symmetry., Comment: We extended our analysis to O(N) theories in various spacetime dimensions featuring different interactions
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- 2024
4. Information index augmented eRG to model vaccination behaviour: A case study of COVID-19 in the US
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Buonomo, Bruno, D'Alise, Alessandra, Della Marca, Rossella, and Sannino, Francesco
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Quantitative Biology - Populations and Evolution ,Mathematics - Dynamical Systems ,Physics - Physics and Society - Abstract
Recent pandemics triggered the development of a number of mathematical models and computational tools apt at curbing the socio-economic impact of these and future pandemics. The need to acquire solid estimates from the data led to the introduction of effective approaches such as the \emph{epidemiological Renormalization Group} (eRG). A recognized relevant factor impacting the evolution of pandemics is the feedback stemming from individuals' choices. The latter can be taken into account via the \textit{information index} which accommodates the information--induced perception regarding the status of the disease and the memory of past spread. We, therefore, show how to augment the eRG by means of the information index. We first develop the {\it behavioural} version of the eRG and then test it against the US vaccination campaign for COVID-19. We find that the behavioural augmented eRG improves the description of the pandemic dynamics of the US divisions for which the epidemic peak occurs after the start of the vaccination campaign. Our results strengthen the relevance of taking into account the human behaviour component when modelling pandemic evolution. To inform public health policies, the model can be readily employed to investigate the socio-epidemiological dynamics, including vaccination campaigns, for other regions of the world., Comment: 19 pages, 4 figures
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- 2024
5. Charting Standard Model Duality and its Signatures
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Cacciapaglia, Giacomo and Sannino, Francesco
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We investigate high and low energy implications of a gauge dual description of the Standard Model. The high energy electric theory features gauge dynamics involving only fermionic matter fields, while the low energy magnetic description features a quasi-supersymmetric spectrum testable at colliders. The flavour theory is constructed via operators generated at the Planck scale. We further show that duality opens novel avenues for theories of grand unification., Comment: 5 pages, 1 figure
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- 2024
6. Defect Induced Heavy Meson Dynamics in the QCD Conformal Window
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Di Risi, Vigilante, Iacobacci, Davide, and Sannino, Francesco
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
Upon introducing an heavy quark in the perturbative regime of the QCD conformal window we precisely determine the associated heavy meson spectrum and wave functions in terms of the number of light flavours and mass. We then compute the conformal Isgur-Wise function which is a central quantity in heavy quark physics. We further determine the impact of the residual low energy confining dynamics on the heavy meson spectrum. As a working framework, we adapt the heavy quark effective theory to the perturbative conformal window dynamics. Our work lays the foundations to systematically go beyond the infinite mass defect approximation in conformal field theories., Comment: LaTeX, 28 pages, several figures
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- 2024
7. Description and Discussion on DCASE 2024 Challenge Task 2: First-Shot Unsupervised Anomalous Sound Detection for Machine Condition Monitoring
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Nishida, Tomoya, Harada, Noboru, Niizumi, Daisuke, Albertini, Davide, Sannino, Roberto, Pradolini, Simone, Augusti, Filippo, Imoto, Keisuke, Dohi, Kota, Purohit, Harsh, Endo, Takashi, and Kawaguchi, Yohei
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Electrical Engineering and Systems Science - Audio and Speech Processing ,Computer Science - Machine Learning ,Computer Science - Sound - Abstract
We present the task description of the Detection and Classification of Acoustic Scenes and Events (DCASE) 2024 Challenge Task 2: First-shot unsupervised anomalous sound detection (ASD) for machine condition monitoring. Continuing from last year's DCASE 2023 Challenge Task 2, we organize the task as a first-shot problem under domain generalization required settings. The main goal of the first-shot problem is to enable rapid deployment of ASD systems for new kinds of machines without the need for machine-specific hyperparameter tunings. This problem setting was realized by (1) giving only one section for each machine type and (2) having completely different machine types for the development and evaluation datasets. For the DCASE 2024 Challenge Task 2, data of completely new machine types were newly collected and provided as the evaluation dataset. In addition, attribute information such as the machine operation conditions were concealed for several machine types to mimic situations where such information are unavailable. We will add challenge results and analysis of the submissions after the challenge submission deadline., Comment: anomaly detection, acoustic condition monitoring, domain shift, first-shot problem, DCASE Challenge. arXiv admin note: text overlap with arXiv:2305.07828
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- 2024
8. Measuring Hawking Radiation from Black Hole Morsels in Astrophysical Black Hole Mergers
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Cacciapaglia, Giacomo, Hohenegger, Stefan, and Sannino, Francesco
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Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology ,High Energy Physics - Phenomenology - Abstract
We show that it is possible to observe the Hawking radiation emitted by small black holes assumed to form in catastrophic astrophysical events such as black hole mergers. Gamma ray bursts in the TeV range are unique footprints of these asteroid-mass black hole morsels ejected during the merger. The time delay of the gamma ray bursts from the gravitational wave event is correlated to the mass distribution of the morsels. The integrated mass of the morsels allowed by the unaccounted merger mass leads to a Hawking induced radiation in photons that is above the sensitivity of atmospheric Cherenkov telescopes such as HESS, LHAASO and HAWC., Comment: 4 pages, 3 figures
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- 2024
9. New Physics Pathways from B Processes
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D'Alise, Alessandra, Fabiano, Giuseppe, Frattulillo, Domenico, Iacobacci, Davide, Sannino, Francesco, Santorelli, Pietro, and Vignaroli, Natascia
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We re-consider recent measures of $R_{K}$ and $R_{K^*}$, now compatible with the Standard Model expectations, as well as the results for the process $\text{BR}(B_s \rightarrow \mu^+ \mu^-)$ alongside earlier determinations of $R_{D^{(\ast)}}$ and $\text{BR}(B_c \rightarrow \tau \nu)$. We provide analytic constraints on the associated Wilson coefficients in both the $b \to s$ and the $b \to c$ sectors. These allow us to estimate the scale of potential New Physics for generic extensions of the Standard Model. We then use the results to constrain the leptoquark landscape., Comment: 39 pages, 5 figures
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- 2024
10. Effective Metric Descriptions of Quantum Black Holes
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Del Piano, Manuel, Hohenegger, Stefan, and Sannino, Francesco
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General Relativity and Quantum Cosmology ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
In a recent work [arXiv:2307.13489 [gr-qc]], we have described spherically symmetric and static quantum black holes as deformations of the classical Schwarzschild metric that depend on the physical distance to the horizon. We have developed a framework that allows to compute the latter in a self-consistent fashion from the deformed geometry, in the vicinity of the horizon. However, in this formalism, the distance can be replaced by other physical quantities, e.g. curvature invariants such as the Ricci- or Kretschmann scalar. Here, we therefore define a more general framework, which we call an "effective metric description" (EMD), that captures the deformed geometry based on a generic physical quantity. We develop in detail the Ricci- and Kretschmann scalar EMD, in particular demonstrating how to compute the geometry in a self-consistent manner. Moreover, we provide explicit relations that allow to express one EMD in terms of the others, thus demonstrating their equivalence., Comment: 24 pages, 4 figures
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- 2024
11. Enhanced Electron Extraction in Co-Doped TiO2 Quantified by Drift-Diffusion Simulation for Stable CsPbI3 Solar Cells
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Gries, Thomas W., Regaldo, Davide, Koebler, Hans, Putri, Titan Noor Hartono, Sannino, Gennaro V., Partida, Emilio Gutierrez, Felix, Roberto, Huesam, Elif, Saleh, Ahmed, Wilks, Regan G., Iqbal, Zafar, Nia, Zahra Loghman, Ruske, Florian, Stolterfoht, Martin, Neher, Dieter, Baer, Marcus, Weber, Stefan A., Veneri, Paola Delli, Schulz, Philip, Puel, Jean-Baptiste, Kleider, Jean-Paul, Wang, Qiong, Unger, Eva, Musiienko, Artem, and Abate, Antonio
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Condensed Matter - Materials Science ,Physics - Applied Physics - Abstract
Solar cells based on inorganic perovskite CsPbI3 are promising candidates to resolve the challenge of operational stability in the field of perovskite photovoltaics. For stable operation, however, it is crucial to thoroughly understand the extractive and recombinative processes occurring at the interfaces of perovskite and the charge-selective layers. In this study, we focus on the electronic properties of (doped) TiO2 as an electron-selective contact. We show via KPFM that co-doping of TiO2 with Nb(V) and Sn(IV) reduces the materials work function by 270 meV, giving it stronger n-type characteristics compared to Nb(V) mono-doped TiO2. The altered electronic alignment with CsPbI3 translates to enhanced electron extraction, as demonstrated with ssPL, trPL and trSPV in triad. Importantly, we extract crucial parameters, such as the concentration of extracted electrons and the interface hole recombination velocity, from the SPV transients via 2D drift-diffusion simulations. When implementing the co-doped TiO2 into full n-i-p solar cells, the operational stability is enhanced to 32000 h of projected TS80 lifetime. This study provides fundamental understanding of interfacial charge extraction and its correlation with operational stability of perovskite solar cells, which can be transferred to other charge-selective contacts., Comment: 20 pages, 2 figures
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- 2024
12. Implementation of a slope stability method in the CRITERIA-1D agro-hydrological modeling scheme
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Sannino, G., Tomei, F., Bittelli, M., Bordoni, M., Meisina, C., and Valentino, R.
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- 2024
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13. Exploring tonsillar cancer associations in patients with base of tongue cancer: insights from a single-center study
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Udholm, Sebastian, Sannino-Greve, Nina B., and Klug, Tejs Ehlers
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- 2024
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14. Counteracting the stigma of homelessness: the finnish Housing First strategy as educational work = Contrapondo o estigma da falta de moradia: a estratégia do programa finlandês Housing First como trabalho educacional = La contraposición del estigma de la falta de vivienda: la estrategia del programa finlandés Housing First como trabajo educativo
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Sannino, Annalisa
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educação inclusiva ,habitação - programas ,educação ,Education (General) ,L7-991 - Abstract
Há uma crescente preocupação global em relação à falta de moradia em muitas cidades afluentes e o estigma associado a esse fenômeno. O estudo foca em como o programa Housing First foi desenvolvido e implementado na Finlândia desde 2008 e está neutralizando o estigma da falta de moradia, facilitando o aprendizado coletivo e a formação de agentes. O estudo comprova este argumento conceitual com a ajuda de exemplos de relatos de jovens que vivenciam ou vivenciaram a falta de moradia e de profissionais que trabalham em unidades habitacionais apoiadas. O referencial teórico do estudo baseia-se no conceito Vygotskiano de déficit secundário e nos conceitos teórico-ativos de aprendizagem expansiva e agentes transformadores. A análise leva a um modelo inicial que descreve as etapas de aprendizagem coletiva e agentes entre atores institucionais e bairros. A análise mostra o papel educacional desempenhado por múltiplos atores e instituições no projeto finlandês para desabrigados a fim de promover novos modos de ação não apenas entre os clientes, mas também dentro da sociedade em geral. Esse papel é exercido por meio de negociações e acordos sistematicamente implementados, que estabelecem vias eficazes fora da marginalização e fora de orientações estigmáticas
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- 2018
15. Renormalisation Group Methods for Effective Epidemiological Models
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Hohenegger, Stefan and Sannino, Francesco
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Quantitative Biology - Populations and Evolution ,High Energy Physics - Theory ,Statistics - Applications - Abstract
Epidemiological models describe the spread of an infectious disease within a population. They capture microscopic details on how the disease is passed on among individuals in various different ways, while making predictions about the state of the entirety of the population. However, the type and structure of the specific model considered typically depend on the size of the population under consideration. To analyse this effect, we study a family of effective epidemiological models in space and time that are related to each other through scaling transformations. Inspired by a similar treatment of diffusion processes, we interpret the latter as renormalisation group transformations, both at the level of the underlying differential equations and their solutions. We show that in the large scale limit, the microscopic details of the infection process become irrelevant, safe for a simple real number, which plays the role of the infection rate in a basic compartmental model., Comment: 36 pages, 19 figures
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- 2024
16. Information Theory Unification of Epidemiological and Population Dynamics
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Filoche, Baptiste, Hohenegger, Stefan, and Sannino, Francesco
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Quantitative Biology - Populations and Evolution ,High Energy Physics - Theory ,Statistics - Applications - Abstract
We reformulate models in epidemiology and population dynamics in terms of probability distributions. This allows us to construct the Fisher information, which we interpret as the metric of a one-dimensional differentiable manifold. For systems that can be effectively described by a single degree of freedom, we show that their time evolution is fully captured by this metric. In this way, we discover universal features across seemingly very different models. This further motivates a reorganisation of the dynamics around zeroes of the Fisher metric, corresponding to extrema of the probability distribution. Concretely, we propose a simple form of the metric for which we can analytically solve the dynamics of the system that well approximates the time evolution of various established models in epidemiology and population dynamics, thus providing a unifying framework., Comment: 33 pages, 17 figures
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- 2024
17. Two-index SU(N) theories: QCD, Orientifolds, Super Yang-Mills, Lattice and Steven Weinberg's $\pi \pi$ scattering legacy
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Sannino, Francesco
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
I review and improve on how two-index SU(N) gauge-fermion theories help access salient information about the large $N$ vacuum and spectrum of QCD, super Yang Mills and meson-meson scattering. The interplay with recent lattice simulations will be employed to deduce the size of $1/N^2$ corrections. Through the meson-meson scattering analysis I will honor Steven Weinberg's memory by showing how two-index extrapolations naturally accommodate the appearance of tetraquarks states crucial to unitarize meson-meson scattering at low energies., Comment: Typos corrected, version to match the one accepted for publication in Nuclear Physics B
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- 2024
18. Infinite order results for charged sectors of the Standard Model
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Antipin, Oleg, Bersini, Jahmall, Panopoulos, Pantelis, Sannino, Francesco, and Wang, Zhi-Wei
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We determine anomalous dimensions of a family of fixed hypercharge operators in the Standard Model featuring the general Cabibbo-Kobayashi-Maskawa structure. The results are obtained at infinite orders in the couplings and to leading and subleading orders in the charge. The computed anomalous dimensions are shown to agree with the maximum known order in perturbation theory. We further show that the large hypercharge sector of the Standard Model is characterised by a non-Abelian vector condensation phase., Comment: 27 pages in LaTeX
- Published
- 2023
19. Fast Reconfiguration Maneuvers of a Micro-satellite Constellation Based on a Hybrid Rocket Engine
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Sannino, Antonio, Mungiguerra, Stefano, Cassese, Sergio, Savino, Raffaele, Fedele, Alberto, and Natalucci, Silvia
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- 2024
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20. The Dilatonic Dynamics of Baryonic Crystals, Branes and Spheres
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Bersini, Jahmall, D'Alise, Alessandra, Torres, Matias, and Sannino, Francesco
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice ,High Energy Physics - Theory ,Nuclear Theory - Abstract
We systematically analyze the impact of dilatonic dynamics on Skyrme spheres, crystals and branes. The effects of the dilatonic model parameters, encompassing different underlying near-conformal dynamics, on the macroscopic properties of Skyrmions such as their mass and radius, are discussed. For spheres and crystals we identify special values of the ratio of the decay constants for which the second order differential equations reduce to a solvable first order system. Additionally, in the case of the crystals, the dilaton presence spatially separates the baryon and isospin charge distributions. For branes, we show how the dilaton smooths out their configurations. Our results are expected to have wide implications from the study of near-conformal dynamics stemming from QCD-like theories to phenomenological investigations of nuclear matter in extreme regimes., Comment: 35 pages, 19 figures
- Published
- 2023
21. Gravitational Waves from Composite Dark Sectors
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Pasechnik, Roman, Reichert, Manuel, Sannino, Francesco, and Wang, Zhi-Wei
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We study under which conditions a first-order phase transition in a composite dark sector can yield an observable stochastic gravitational-wave signal. To this end, we employ the Linear-Sigma model featuring $N_f=3,4,5$ flavours and perform a Cornwall-Jackiw-Tomboulis computation also accounting for the effects of the Polyakov loop. The model allows us to investigate the chiral phase transition in regimes that can mimic QCD-like theories incorporating in addition composite dynamics associated with the effects of confinement-deconfinement phase transition. A further benefit of this approach is that it allows to study the limit in which the effective interactions are weak. We show that strong first-order phase transitions occur for weak effective couplings of the composite sector leading to gravitational-wave signals potentially detectable at future experimental facilities., Comment: 19 pages, 8 figures
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- 2023
22. $\Lambda_b \rightarrow \Lambda_c^{\ast}$ at $1\,/\,m_c^2$ heavy quark order
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Di Risi, Vigilante, Iacobacci, Davide, and Sannino, Francesco
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High Energy Physics - Phenomenology ,High Energy Physics - Lattice - Abstract
We systematically compute the $\Lambda_b(p, s_b) \to \Lambda_c(2595)^+$ and $\Lambda_b(p, s_b) \to \Lambda_c(2625)^+$ form factors within the Heavy Quark Effective Theory (HQET) framework including $\mathcal{O}(1/m_c^2)$. Besides taking into account the Standard Model-like vector and axial contributions, we further determine tensor and pseudo-tensor form factors. Our work constitutes a step forward with respect to previous analyses allowing for a comprehensive study of the matrix element parametrisation stemming from the HQET formalism. Finally, we demonstrate that the resulting form factors agree well with lattice Quantum Chromodynamics (LQCD) determinations stressing the need and relevance of the newly derived $1/m_c^2$ corrections., Comment: Revised version with typos corrected. 66 pages, one figure with 10 subfigures
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- 2023
23. Stress biology: Complexity and multifariousness in health and disease.
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Mayer, Matthias, Blair, Laura, Blatch, Gregory, Borges, Thiago, Chadli, Ahmed, Chiosis, Gabriela, de Thonel, Aurélie, Dinkova-Kostova, Albena, Ecroyd, Heath, Edkins, Adrienne, Eguchi, Takanori, Fleshner, Monika, Foley, Kevin, Fragkostefanakis, Sotirios, Gestwicki, Jason, Goloubinoff, Pierre, Heritz, Jennifer, Heske, Christine, Hibshman, Jonathan, Joutsen, Jenny, Li, Wei, Lynes, Michael, Mendillo, Marc, Mivechi, Nahid, Mokoena, Fortunate, Okusha, Yuka, Prahlad, Veena, Repasky, Elizabeth, Sannino, Sara, Scalia, Federica, Shalgi, Reut, Sistonen, Lea, Sontag, Emily, van Oosten-Hawle, Patricija, Vihervaara, Anniina, Wickramaratne, Anushka, Wang, Shawn, and Zininga, Tawanda
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Heat shock proteins ,Heat shock response ,Heat shock transcription factors ,Molecular chaperones ,Protein folding diseases ,Stress response ,Heat-Shock Proteins ,Molecular Chaperones ,Heat-Shock Response ,Medicine ,Biology - Abstract
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
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- 2024
24. The exceptional form and function of the giant bacterium Ca. Epulopiscium viviparus revolves around its sodium motive force
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Sannino, David R, Arroyo, Francine A, Pepe-Ranney, Charles, Chen, Wenbo, Volland, Jean-Marie, Elisabeth, Nathalie H, and Angert, Esther R
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Microbiology ,Biological Sciences ,Genetics ,Nutrition ,2.2 Factors relating to the physical environment ,Infection ,Animals ,Sodium ,Bacteria ,Clostridiales ,Vacuolar Proton-Translocating ATPases ,Adenosine Triphosphate ,ATPase ,cellular bioenergetics ,giant bacteria ,gut microbiota ,polyploid - Abstract
Epulopiscium spp. are the largest known heterotrophic bacteria; a large cigar-shaped individual is a million times the volume of Escherichia coli. To better understand the metabolic potential and relationship of Epulopiscium sp. type B with its host Naso tonganus, we generated a high-quality draft genome from a population of cells taken from a single fish. We propose the name Candidatus Epulopiscium viviparus to describe populations of this best-characterized Epulopiscium species. Metabolic reconstruction reveals more than 5% of the genome codes for carbohydrate active enzymes, which likely degrade recalcitrant host-diet algal polysaccharides into substrates that may be fermented to acetate, the most abundant short-chain fatty acid in the intestinal tract. Moreover, transcriptome analyses and the concentration of sodium ions in the host intestinal tract suggest that the use of a sodium motive force (SMF) to drive ATP synthesis and flagellar rotation is integral to symbiont metabolism and cellular biology. In natural populations, genes encoding both F-type and V-type ATPases and SMF generation via oxaloacetate decarboxylation are among the most highly expressed, suggesting that ATPases synthesize ATP and balance ion concentrations across the cell membrane. High expression of these and other integral membrane proteins may allow for the growth of its extensive intracellular membrane system. Further, complementary metabolism between microbe and host is implied with the potential provision of nitrogen and B vitamins to reinforce this nutritional symbiosis. The few features shared by all bacterial behemoths include extreme polyploidy, polyphosphate synthesis, and thus far, they have all resisted cultivation in the lab.
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- 2023
25. Antimicrobial and Superhydrophobic CuONPs/TiO2 Hybrid Coating on Polypropylene Substrates against Biofilm Formation
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Sudipto Pal, Stefania Villani, Antonella Mansi, Anna Maria Marcelloni, Alessandra Chiominto, Ilaria Amori, Anna Rita Proietto, Matteo Calcagnile, Pietro Alifano, Sonia Bagheri, Claudio Mele, Antonio Licciulli, Alessandro Sannino, and Christian Demitri
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Chemistry ,QD1-999 - Published
- 2024
- Full Text
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26. UV finite GUT with SUSY Breaking
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Bajc, Borut, Del Piano, Manuel, and Sannino, Francesco
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We provide an example of an ultraviolet finite supersymmetric grand unified theory of safe rather than free nature endowed with a supersymmetric dynamical breaking mechanism. Our results simultaneously enlarge the number of ultraviolet consistent supersymmetric grand unified theories while providing a relevant example of how to achieve a consistent ultraviolet safe extension of the Standard Model enjoying the benefits of grand unified theories., Comment: 9 pages, 1 figure
- Published
- 2023
27. Living on the Edge: Quantum Black Hole Physics from the Event Horizon
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Del Piano, Manuel, Hohenegger, Stefan, and Sannino, Francesco
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General Relativity and Quantum Cosmology ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
Quantum gravity theories predict deformations of black hole solutions relative to their classical counterparts. A model-independent approach was advocated in \cite{Binetti:2022xdi} that uses metric deformations parametrised in terms of physical quantities, such as the proper distance. While such a description manifestly preserves the invariance of the space-time under coordinate transformations, concrete computations are hard to tackle since the distance is defined in terms of the deformed metric itself. In this work, for spherically symmetric and static metrics, we provide a self-consistent framework allowing us to compute the distance function in close vicinity to the event horizon of a black hole. By assuming a minimal degree of regularity at the horizon, we provide explicit (series) expansions of the metric. This allows us to compute important thermodynamical quantities of the black hole, such as the Hawking temperature and entropy, for which we provide model-independent expressions, beyond a large mass expansion. Moreover, imposing for example the absence of curvature singularities at the event horizon leads to non-trivial consistency conditions for the metric deformations themselves, which we find to be violated by some models in the literature., Comment: 49 pages, 9 figures
- Published
- 2023
28. Interface Modification for Energy Levels Alignment and Charge Extraction in CsPbI$_3$ Perovskite Solar Cells
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Iqbal, Zafar, Zu, Fengshuo, Musiienko, Artem, Partida, Emilio Gutierrez, Kobler, Hans, Gries, Thomas W., Sannino, Gennaro V., Canil, Laura, Koch, Norbert, Stolterfoht, Martin, Neher, Dieter, Pavone, Michele, Munoz-Garcia, Ana Belen, Abate, Antonio, and Wang, Qiong
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Condensed Matter - Materials Science ,Physics - Chemical Physics - Abstract
In perovskite solar cells (PSCs) energy levels alignment and charge extraction at the interfaces are the essential factors directly affecting the device performance. In this work, we present a modified interface between all-inorganic CsPbI$_3$ perovskite and its hole selective contact (Spiro-OMeTAD), realized by a dipole molecule trioctylphosphine oxide (TOPO), to align the energy levels. On a passivated perovskite film, by n-Octyl ammonium Iodide (OAI), we created an upward surface band-bending at the interface by TOPO treatment. This improved interface by the dipole molecule induces a better energy level alignment and enhances the charge extraction of holes from the perovskite layer to the hole transport material. Consequently, a Voc of 1.2 V and high-power conversion efficiency (PCE) of over 19% were achieved for inorganic CsPbI$_3$ perovskite solar cells. Further, to demonstrate the effect of the TOPO dipole molecule, we present a layer-by-layer charge extraction study by transient surface photovoltage technique (trSPV) accomplished by charge transport simulation., Comment: 20 pages, 4 Figures
- Published
- 2023
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29. Adapting buffalo calves to automated milk feeding: initial observations and future implications
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Maura Sannino, Francesco Serrapica, Salvatore Faugno, Felicia Masucci, Grazia Scalera, Giuseppe De Rosa, Costanza Fiorentino, and Antonio Di Francia
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automatic milk feeder ,buffalo calf ,precision livestock farming ,Animal culture ,SF1-1100 - Abstract
An on-farm observational study evaluated the use of individual automatic milk feeders (AMF) to wean 53 buffalo calves. Analysis of data retrieved from the AMF system over a 4-month period revealed positive indicators for animal adaptation, including rapid self-feeding behaviour, low incidence of feeding refusals, high milk intake, consistent weight gain, and increased frequency of daily feedings. The study identified potential areas for future research, such as determining the optimal number and frequency of feedings and the appropriate milk allowance for different stages of calf development. These findings suggest potential benefits for labour cost savings and emphasise the need to optimise AMF parameters to meet the specific needs of buffalo calves.
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- 2024
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30. Detection and quantification of Brucella abortus DNA in water buffaloes (bubalus bubalis) using droplet digital polymerase chain reaction
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Giovanna Fusco, Lorena Cardillo, Ornella Valvini, Alessia Pucciarelli, Gerardo Picazio, Anna Cerrone, Michele Napoletano, Roberta Pellicanò, Maria Ottaiano, Claudio de Martinis, Francesca De Falco, Anna Cutarelli, Emanuela Sannino, Giorgia Borriello, Manuela Tittarelli, Sante Roperto, and Esterina De Carlo
- Subjects
Brucella abortus ,droplet digital-PCR ,real-time PCR ,bacterial culture ,water buffalo ,Sensitivity ,Veterinary medicine ,SF600-1100 - Abstract
Brucellosis represents a major public health concern worldwide. Human transmission is mainly due to the consumption of unpasteurized milk and dairy products of infected animals. The gold standard for the diagnosis of Brucella spp in ruminants is the bacterial isolation, but it is time-consuming. Polymerase Chain Reaction (PCR) is a quicker and more sensitive technique than bacterial culture. Droplet digital PCR (ddPCR) is a novel molecular assay showing high sensitivity in samples with low amount of DNA and lower susceptibility to amplification inhibitors. Present study aimed to develop a ddPCR protocol for the detection of Brucella abortus in buffalo tissue samples. The protocol was validated using proficiency test samples for Brucella spp by real time qPCR. Furthermore, 599 tissue samples were examined. Among reference materials, qPCR and ddPCR demonstrated same performance and were able to detect up to 225 CFU/mL. Among field samples, ddPCR showed higher sensitivity (100%), specificity and accuracy of 93.4% and 94.15%, respectively. ddPCR could be considered a promising technique to detect B. abortus in veterinary specimens, frequently characterized by low amount of bacteria, high diversity in matrices and species and poor storage conditions.
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- 2024
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31. Mitochondrial DNA editing in potato through mitoTALEN and mitoTALECD: molecular characterization and stability of editing events
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Nicolia, Alessandro, Scotti, Nunzia, D’Agostino, Nunzio, Festa, Giovanna, Sannino, Lorenza, Aufiero, Gaetano, Arimura, Shin-ichi, and Cardi, Teodoro
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- 2024
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32. Real-world management of chronic and postprandial hyperkalemia in CKD patients treated with patiromer: a single-center retrospective study
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Riccio, Eleonora, D’Ercole, Anna, Sannino, Anna, Hamzeh, Sarah, De Marco, Oriana, Capuano, Ivana, Buonanno, Pasquale, Rizzo, Manuela, and Pisani, Antonio
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- 2024
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33. Dynamical downscaling of CMIP6 scenarios with ENEA-REG: an impact-oriented application for the Med-CORDEX region
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Anav, Alessandro, Antonelli, Marta, Calmanti, Sandro, Carillo, Adriana, Catalano, Franco, Dell’Aquila, Alessandro, Iacono, Roberto, Marullo, Salvatore, Napolitano, Ernesto, Palma, Massimiliano, Pisacane, Giovanna, Sannino, Gianmaria, and Struglia, Maria Vittoria
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- 2024
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34. Positivity Conditions for Generalised Schwarzschild Space-Times
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D'Alise, A., Fabiano, G., Frattulillo, D., Hohenegger, S., Iacobacci, D., Pezzella, F., and Sannino, F.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
We analyse the impact of positivity conditions on static spherically symmetric deformations of the Schwarzschild space-time. The metric is taken to satisfy, at least asymptotically, the Einstein equation in the presence of a non-trivial stress-energy tensor, on which we impose various physicality conditions. We systematically study and compare the impact of these conditions on the space-time deformations. The universal nature of our findings applies to both classical and quantum metric deformations with and without event horizons. We further discuss minimal realisations of the asymptotic stress energy tensor in terms of physical fields. Finally, we illustrate our results by discussing concrete models of quantum black holes., Comment: LaTeX, 40 pages, 9 figures
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- 2023
35. Privacy-Enhancing Technologies in Federated Learning for the Internet of Healthcare Things: A Survey
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Mosaiyebzadeh, Fatemeh, Pouriyeh, Seyedamin, Parizi, Reza M., Sheng, Quan Z., Han, Meng, Zhao, Liang, Sannino, Giovanna, and Batista, Daniel Macêdo
- Subjects
Computer Science - Networking and Internet Architecture - Abstract
Advancements in wearable medical devices in IoT technology are shaping the modern healthcare system. With the emergence of the Internet of Healthcare Things (IoHT), we are witnessing how efficient healthcare services are provided to patients and how healthcare professionals are effectively used AI-based models to analyze the data collected from IoHT devices for the treatment of various diseases. To avoid privacy breaches, these data must be processed and analyzed in compliance with the legal rules and regulations such as HIPAA and GDPR. Federated learning is a machine leaning based approach that allows multiple entities to collaboratively train a ML model without sharing their data. This is particularly useful in the healthcare domain where data privacy and security are big concerns. Even though FL addresses some privacy concerns, there is still no formal proof of privacy guarantees for IoHT data. Privacy Enhancing Technologies (PETs) are a set of tools and techniques that are designed to enhance the privacy and security of online communications and data sharing. PETs provide a range of features that help protect users' personal information and sensitive data from unauthorized access and tracking. This paper reviews PETs in detail and comprehensively in relation to FL in the IoHT setting and identifies several key challenges for future research., Comment: 15 pages, 4 figures, 5 tables
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- 2023
36. Voice signals database of ALS patients with different dysarthria severity and healthy controls
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Raffaele Dubbioso, Myriam Spisto, Laura Verde, Valentina Virginia Iuzzolino, Gianmaria Senerchia, Elena Salvatore, Giuseppe De Pietro, Ivanoe De Falco, and Giovanna Sannino
- Subjects
Science - Abstract
Abstract This paper describes a new publicly-available database of VOiCe signals acquired in Amyotrophic Lateral Sclerosis (ALS) patients (VOC-ALS) and healthy controls performing different speech tasks. This dataset consists of 1224 voice signals recorded from 153 participants: 51 healthy controls (32 males and 19 females) and 102 ALS patients (65 males and 37 females) with different severity of dysarthria. Each subject’s voice was recorded using a smartphone application (Vox4Health) while performing several vocal tasks, including a sustained phonation of the vowels /a/, /e/, /i/, /o/, /u/ and /pa/, /ta/, /ka/ syllable repetition. Basic derived speech metrics such as harmonics-to-noise ratio, mean and standard deviation of fundamental frequency (F0), jitter and shimmer were calculated. The F0 standard deviation of vowels and syllables showed an excellent ability to identify people with ALS and to discriminate the different severity of dysarthria. These data represent the most comprehensive database of voice signals in ALS and form a solid basis for research on the recognition of voice impairment in ALS patients for use in clinical applications.
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- 2024
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37. Retraction Note: Evaluation of artificial intelligence techniques for the classification of different activities of daily living and falls
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De Falco, Ivanoe, De Pietro, Giuseppe, and Sannino, Giovanna
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- 2024
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38. Spectrum of QCD with one flavor: A window for supersymmetric dynamics
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Della Morte, Michele, Jäger, Benjamin, Sannino, Francesco, Tsang, Justus Tobias, and Ziegler, Felix P. G.
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High Energy Physics - Lattice ,High Energy Physics - Theory - Abstract
We compute the spectrum of the low-lying mesonic states with vector, scalar and pseudoscalar quantum numbers in QCD with one flavour. With three colours the fundamental and the two-index anti-symmetric representations of the gauge group coincide. The latter is an orientifold theory that maps into the bosonic sector of $\mathcal{N} = 1$ super Yang-Mills theory in the large number of colours limit. We employ Wilson fermions along with tree-level improvement in the gluonic and fermionic parts of the action. In this setup the Dirac operator can develop real negative eigenvalues. We therefore perform a detailed study in order to identify configurations where the fermion determinant is negative and eventually reweight them. We finally compare results with effective field theory predictions valid in the large $N_C$ limit and find reasonably consistent values despite $N_C$ being only three. Additionally,the spin-one sector provides a novel window for supersymmetric dynamics., Comment: Version accepted and published by PRD (Phys. Rev. D 107, 114506)
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- 2023
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39. Phase Transitions in Particle Physics -- Results and Perspectives from Lattice Quantum Chromo-Dynamics
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Aarts, Gert, Aichelin, Joerg, Allton, Chris, Athenodorou, Andreas, Bachtis, Dimitrios, Bonanno, Claudio, Brambilla, Nora, Bratkovskaya, Elena, Bruno, Mattia, Caselle, Michele, Conti, Costanza, Contino, Roberto, Cosmai, Leonardo, Cuteri, Francesca, Del Debbio, Luigi, D'Elia, Massimo, Dimopoulos, Petros, Di Renzo, Francesco, Galatyuk, Tetyana, Guenther, Jana N., Houtz, Rachel, Karsch, Frithjof, Kotov, Andrey Yu., Lombardo, Maria Paola, Lucini, Biagio, Maio, Lorenzo, Panero, Marco, Pawlowski, Jan M., Pelissetto, Andrea, Philipsen, Owe, Rago, Antonio, Ratti, Claudia, Ryan, Sinéad M., Sannino, Francesco, Sasaki, Chihiro, Schicho, Philipp, Schmidt, Christian, Sharma, Sipaz, Soloveva, Olga, Sorba, Marianna, and Wiese, Uwe-Jens
- Subjects
High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,High Energy Physics - Theory ,Nuclear Theory - Abstract
Phase transitions in a non-perturbative regime can be studied by ab initio Lattice Field Theory methods. The status and future research directions for LFT investigations of Quantum Chromo-Dynamics under extreme conditions are reviewed, including properties of hadrons and of the hypothesized QCD axion as inferred from QCD topology in different phases. We discuss phase transitions in strong interactions in an extended parameter space, and the possibility of model building for Dark Matter and Electro-Weak Symmetry Breaking. Methodological challenges are addressed as well, including new developments in Artificial Intelligence geared towards the identification of different phases and transitions., Comment: 94 pages, 23 figures, GGI workshop "Phase Transitions in Particle Physics" review - v2: minor revisions and typo corrected, matches accepted version on PPNP
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- 2023
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40. Exploring the large-$N_c$ limit with one quark flavour
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Della Morte, Michele, Jäger, Benjamin, Martins, Sofie, Sannino, Francesco, Tsang, J. Tobias, and Ziegler, Felix P. G.
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High Energy Physics - Lattice - Abstract
We use one-flavour QCD ($N_c=3$) as a proxy to understand $\mathcal{N}=1$ SYM. For our simulations, we use tree-level improved Wilson fermions and Symanzik improved gauge action. The hadron spectrum is obtained by using LapH smearing for different masses and simulation volumes. We also report on our efforts to increase the number of colours in our simulations, where we find that the simulations show increasing topological freezing for larger $N_c$., Comment: 9 pages, 6 figures, Proceedings of the 39th International Symposium on Lattice Field Theory, 8th-13th August 2022, Bonn, Germany
- Published
- 2022
41. Genotoxicity of radiofrequency electromagnetic fields on mammalian cells in vitro: A systematic review with narrative synthesis
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Stefania Romeo, Anna Sannino, Maria Rosaria Scarfì, Susanna Lagorio, and Olga Zeni
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Radiofrequency electromagnetic fields ,Genotoxicity ,In vitro ,Systematic review ,Environmental sciences ,GE1-350 - Abstract
Background: Over the last decades, great concern has been raised about possible adverse effects to human health due to exposures to radiofrequency electromagnetic fields (RF-EMF, 100 kHz – 300 GHz) emitted by wireless communication technologies. In 2011 the International Agency for Research on Cancer classified RF-EMF as possibly carcinogenic to humans, highlighting that the evidence was weak and far from conclusive. Updated systematic reviews of the scientific literature on this topic are lacking, especially for mechanistic studies. Objectives: To perform a systematic review of the scientific literature on genotoxic effects induced by RF-EMF in in vitro experimental models. The overall aim is to assess the confidence and level of evidence of the induced effects in mammalian cell cultures. Methods: Full details regarding the eligibility criteria, information sources, and methods developed to assess risk of bias in the included study, are reported in our published protocol (Romeo et al. 2021). The databases NCBI PubMed, Web of Science, and EMF-Portal were used as information sources (last searched on 31st December 2022). In developing the systematic review, we followed the guidelines provided by the National Toxicology Program-Office of Health Assessment and Translation (NTP-OHAT), adapted to the evaluation of in vitro studies. A narrative synthesis of the body of evidence was performed by tabulating data classified according to meaningful groups (endpoints) and sub-groups (exposure parameters). This report, abstract included, conforms to the PRISMA 2020 (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. Results: Out of 7750 unique records identified, 159 articles were eligible for inclusion. From the extracted data, we identified 1111 experiments (defined as independent specific combinations of diverse biological and electromagnetic parameters). The large majority (80%) of experiments reviewed did not show statistically significant genotoxic effects of RF-EMF exposures, and most “positive” studies were rated as of moderate to low quality, with negative ratings in the key bias domains. A qualitative evidence appraisal was conducted at the endpoint level, and then integrated across endpoints. Discussion: To the best of our knowledge, this is the first systematic review of the scientific literature on genotoxic effects in mammalian cell cultures in relation to RF-EMF exposure, which confirms and strengthens conclusions from previous syntheses of this specific topic thanks to the use of transparently reported methods, pre-defined inclusion criteria, and formal assessment of susceptibility to bias. Limitations of the evidence included the frequent reporting of findings in graphical display only, and the large heterogeneity of experimental data, which precluded a meta-analysis. Conclusions: In the assessment restricted to studies reporting a significant effect of the exposure on the outcome, we reached an overall assessment of “low” confidence in the evidence that RF-EMF induce genotoxic effects in mammalian cells. However, 80% of experiments reviewed showed no effect of RF exposure on the large majority of endpoints, especially the irreversible ones, independently of the exposure features, level, and duration (moderate evidence of no effect). Therefore, we conclude that the analysis of the papers included in this review, although only qualitative, suggests that RF exposure does not increase the occurrence of genotoxic effects in vitro. Framework and funding: This systematic review addresses one of the evidence streams considered in a larger systematic review of the scientific literature on the potential carcinogenicity of RF-EMF, performed by scientists from several Italian public research agencies. The project is supported by the Italian Workers’ Compensation Authority (INAIL) in the framework of the CRA with the Istituto Superiore di Sanità “BRiC 2018/06 – Scientific evidence on the carcinogenicity of electromagnetic fields”.
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- 2024
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42. Fibrofolliculomas in Birt-Hogg-Dubé Syndrome treated with a CO2 and dye laser combination: a case report and literature review
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Giuseppe Lodi, Giovanni Cannarozzo, Mario Sannino, Laura Pieri, Irene Fusco, and Francesca Negosanti
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Birt-Hogg-Dubè Syndrome ,folliculin ,fibrofolliculoma ,fractionallly ablative CO2 laser ,dye laser ,Dermatology ,RL1-803 - Abstract
The Birt-Hogg-Dubé Syndrome (BHDs) can cause benign skin lesions like fibrofolliculomas as well as additional systemic symptoms like pulmonary cysts, kidney tumors, and recurrent pneumothoraces. We report the successful treatment of fibrofolliculomas in a patient with BHDs using a combination of fractionated ablative CO2 laser and a Flash Lamp Pulsed Dye Laser (FPDL). This combined method improves the CO2 healing process's functional and cosmetic results; while the first wavelength (ablative) has a greater capacity for excision and tissue regeneration, the second wavelength (non-ablative) provides more control over the tissue healing process. The lesions were successfully ablated up to the papillary dermis without leading to an enhancement in the overall textural appearance. Therefore, deeper laser ablations may be able to stop dermal residual lesion relapses. In conclusion, fractionated CO2 laser and FPDL can be used safely and effectively to reduce the appearance of facial hamartomas related to BHDs.
- Published
- 2024
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43. From controlled experiments to formative interventions in studies of agency: methodological considerations = De experimentos controlados a intervenções formativas em estudos de agência: considerações metodológicas = De experimentos controlados a intervenciones formativas en estudios de agencia: consideraciones metodológicas
- Author
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Laitinen, Anne, Sannino, Annalisa, and Engeström, Yrjö
- Subjects
ciências sociais - pesquisas ,pesquisas - metodologia ,Education (General) ,L7-991 - Abstract
O artigo explora a possibilidade de desenvolver uma metodologia para estudar o surgimento da ação agentiva experimentalmente. Ele discute as limitações da pesquisa experimental clássica e busca uma perspectiva diferente sobre a questão do controle. O argumento começa por analisar como o conceito de uma experiência tem se expandido ao longo dos anos na pesquisa científica social. Em seguida, novas aberturas são consideradas para experiências além do paradigma de controle e uma metodologia de intervenções formativas, particularmente adequadas ao estudo do surgimento de ações agentivas. São sugeridas três qualidades centrais de experimentos além do paradigma de controle dentro da abordagem histórico-cultural, a saber: (1) construir sobre os conflitos de motivação dos participantes; (2) focalizar a formação de ações agentivas dos participantes de dar sentido e transformar a situação experimental (3) seguindo com expansões temporais e espaciais para além do quadro inicial da experiência. O artigo conclui com uma discussão das implicações metodológicas mais amplas dessas novas aberturas
- Published
- 2016
44. Integrating Impedance Spectroscopy and Perceptron-Based Classification for Tooth Treatment Monitoring.
- Author
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Isabella Sannino, Leila Es Sebar, Luca Lombardo, Marco Parvis, Allegra Comba, Nicola Scotti, Emma Angelini, and Sabrina Grassini
- Published
- 2024
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45. The Equitable and Sustainable well-being Through the Pandemic: A Preliminary Study to Assess Changes at Local Level in Italy
- Author
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Davino, Cristina, Sannino, Pasquale, Taralli, Stefania, Dolce, Pasquale, Gaul, Wolfgang, Managing Editor, Vichi, Maurizio, Managing Editor, Weihs, Claus, Managing Editor, Baier, Daniel, Editorial Board Member, Critchley, Frank, Editorial Board Member, Decker, Reinhold, Editorial Board Member, Diday, Edwin, Editorial Board Member, Greenacre, Michael, Editorial Board Member, Lauro, Carlo Natale, Editorial Board Member, Meulman, Jacqueline, Editorial Board Member, Monari, Paola, Editorial Board Member, Nishisato, Shizuhiko, Editorial Board Member, Ohsumi, Noboru, Editorial Board Member, Opitz, Otto, Editorial Board Member, Ritter, Gunter, Editorial Board Member, Schader, Martin, Editorial Board Member, Davino, Cristina, editor, Palumbo, Francesco, editor, Wilhelm, Adalbert F. X., editor, and Kestler, Hans A., editor
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- 2024
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46. Epsilon toxin-producing Clostridium perfringens colonize the MS gut and epsilon toxin overcomes immune privilege
- Author
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Ma, Yinghua, Sannino, David, Linden, Jennifer R, Haigh, Sylvia, Zhao, Baohua, Grigg, John B, Zumbo, Paul, Dündar, Friederike, Butler, Daniel J, Profaci, Caterina P, Telesford, Kiel M, Winokur, Paige N, Rumah, Kareem R, Gauthier, Susan A, Fischetti, Vincent A, McClane, Bruce A, Uzal, Francisco A, Zexter, Lily, Mazzucco, Michael, Rudick, Richard, Danko, David, Balmuth, Evan, Nealon, Nancy, Perumal, Jai, Kaunzner, Ulrike W, Brito, Ilana L, Chen, Zhengming, Xiang, Jenny Z, Betel, Doron, Daneman, Richard, Sonnenberg, Gregory F, Mason, Christopher E, and Vartanian, Timothy
- Subjects
Multiple Sclerosis ,Neurosciences ,Brain Disorders ,Neurodegenerative ,Autoimmune Disease ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Animals ,Humans ,Clostridium perfringens ,Gastrointestinal Microbiome ,Immune Privilege ,Lymphocytes ,Encephalomyelitis ,Autoimmune ,Experimental ,Autoimmunity ,Demyelinating disorders ,Microbiology ,Multiple sclerosis ,Toxins/drugs/xenobiotics ,Medical and Health Sciences ,Immunology - Abstract
Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To address this knowledge gap, we used sensitive and quantitative PCR detection to show that people with MS were more likely to harbor and show a greater abundance of epsilon toxin-producing (ETX-producing) strains of C. perfringens within their gut microbiomes compared with individuals who are healthy controls (HCs). Isolates derived from patients with MS produced functional ETX and had a genetic architecture typical of highly conjugative plasmids. In the active immunization model of experimental autoimmune encephalomyelitis (EAE), where pertussis toxin (PTX) is used to overcome CNS immune privilege, ETX can substitute for PTX. In contrast to PTX-induced EAE, where inflammatory demyelination is largely restricted to the spinal cord, ETX-induced EAE caused demyelination in the corpus callosum, thalamus, cerebellum, brainstem, and spinal cord, more akin to the neuroanatomical lesion distribution seen in MS. CNS endothelial cell transcriptional profiles revealed ETX-induced genes that are known to play a role in overcoming CNS immune privilege. Together, these findings suggest that ETX-producing C. perfringens strains are biologically plausible pathogens in MS that trigger inflammatory demyelination in the context of circulating myelin autoreactive lymphocytes.
- Published
- 2023
47. The Radiative Flavor Template at the LHC: Lepton non-universality and g-2
- Author
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Cacciapaglia, Giacomo, Cagnotta, Antimo, Calabrese, Roberta, Carnevali, Francesco, De Iorio, Agostino, Iorio, Alberto Orso Maria, Morisi, Stefano, and Sannino, Francesco
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
The Standard Model of Particle Physics and its description of Nature have been recently challenged by a series of precision measurements performed via different accelerator machines. Statistically significant anomalies emerged in the heavy meson physics sector, when measuring the muon magnetic momentum, and very recently when deducing the mass of the W boson. Here we consider a radiative extension of the Standard Model devised to be sufficiently versatile to reconcile the various experimental results while further predicting the existence of new bosons and fermions with a mass spectrum in the TeV energy scale. The resulting spectrum is, therefore, within the energy reach of the proton-proton collisions at the LHC experiments at CERN. The model investigated here allows to interpolate between composite and elementary extensions of the Standard Model with emphasis on a new modified Yukawa sector that is needed to accommodate the anomalies. Focusing on the radiative regime of the model, we introduce interesting search channels of immediate impact for the ATLAS and CMS experimental programs such as the associate production of Standard Model particles with either invisible or long-lived particles. We further show how to adapt earlier SUSY-motivated searchers of new physics to constrain the spectrum and couplings of the new scalars and fermions. Overall, the new physics template simultaneously accounts for the bulk of the observed experimental anomalies while suggesting a wide spectrum of experimental signatures relevant for the current LHC experiments., Comment: 38 pages, 60 figures, 4 tables
- Published
- 2022
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48. Normalization of Spexin Levels in Patients with Obesity Submitted to Bariatric Surgery
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Bufano, Annalisa, Iraci Sareri, Gabriele, Ciuoli, Cristina, Cantara, Silvia, Marzocchi, Carlotta, Benenati, Nicoletta, Batzibal, Maria Simon, Bombardieri, Alessio, Caprio, Sonia, Sannino, Ida, Voglino, Costantino, Tirone, Andrea, Vuolo, Giuseppe, Dalmiglio, Cristina, and Castagna, Maria Grazia
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- 2024
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49. Artificial Intelligence and Mitral Regurgitation: Friend or Foe?
- Author
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Sannino, Anna and Mahkmudova, Umidakhon
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- 2024
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50. Real-world clinical and psychosocial outcomes among people with mild or moderate haemophilia A treated on-demand in the Italian CHESS II cohort: a real-world data analysis
- Author
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Castaman Giancarlo, Mancuso Maria Elisa, Di Minno Matteo Nicola Dario, Sannino Luigi, Tempre Rosaria, Bendinelli Sara, Blenkiron Tom, Burke Tom, and Grazzi Enrico Ferri
- Subjects
haemophilia a ,annual bleeding rate ,joint arthropathy ,pain ,patient-reported outcomes ,health-related quality of life ,psychosocial burden ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
The burden of severe haemophilia A (HA) has been studied extensively owing to the higher bleeding frequency and associated treatment requirements, leaving a clear unmet need for research focused on the burden of mild and moderate HA.
- Published
- 2024
- Full Text
- View/download PDF
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