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1. Subsequent biologic and targeted synthetic disease modifying anti rheumatic drugs after fulfilling difficult-to-treat rheumatoid arthritis criteria: a survival analysis

Author

Novella-Navarro, Marta, Ruiz-Esquide, Virginia, López-Juanes, Natalia, Chacur, Chafik Alejandro, Monjo-Henry, Irene, Nuño, Laura, Peiteado, Diana, Villalba, Alejandro, Fernández-Fernandez, Elisa, Sanz-Jardón, María, Kafati, Mónica, Sanmartí, Raimon, Plasencia-Rodríguez, Chamaida, and Balsa, Alejandro

Published
2024
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2. Widespread horse-based mobility arose around 2200 bce in Eurasia

Author

Librado, Pablo, Tressières, Gaetan, Chauvey, Lorelei, Fages, Antoine, Khan, Naveed, Schiavinato, Stéphanie, Calvière-Tonasso, Laure, Kusliy, Mariya A., Gaunitz, Charleen, Liu, Xuexue, Wagner, Stefanie, Der Sarkissian, Clio, Seguin-Orlando, Andaine, Perdereau, Aude, Aury, Jean-Marc, Southon, John, Shapiro, Beth, Bouchez, Olivier, Donnadieu, Cécile, Collin, Yvette Running Horse, Gregersen, Kristian M., Jessen, Mads Dengsø, Christensen, Kirsten, Claudi-Hansen, Lone, Pruvost, Mélanie, Pucher, Erich, Vulic, Hrvoje, Novak, Mario, Rimpf, Andrea, Turk, Peter, Reiter, Simone, Brem, Gottfried, Schwall, Christoph, Barrey, Éric, Robert, Céline, Degueurce, Christophe, Horwitz, Liora Kolska, Klassen, Lutz, Rasmussen, Uffe, Kveiborg, Jacob, Johannsen, Niels Nørkjær, Makowiecki, Daniel, Makarowicz, Przemysław, Szeliga, Marcin, Ilchyshyn, Vasyl, Rud, Vitalii, Romaniszyn, Jan, Mullin, Victoria E., Verdugo, Marta, Bradley, Daniel G., Cardoso, João L., Valente, Maria J., Telles Antunes, Miguel, Ameen, Carly, Thomas, Richard, Ludwig, Arne, Marzullo, Matilde, Prato, Ornella, Bagnasco Gianni, Giovanna, Tecchiati, Umberto, Granado, José, Schlumbaum, Angela, Deschler-Erb, Sabine, Mráz, Monika Schernig, Boulbes, Nicolas, Gardeisen, Armelle, Mayer, Christian, Döhle, Hans-Jürgen, Vicze, Magdolna, Kosintsev, Pavel A., Kyselý, René, Peške, Lubomír, O’Connor, Terry, Ananyevskaya, Elina, Shevnina, Irina, Logvin, Andrey, Kovalev, Alexey A., Iderkhangai, Tumur-Ochir, Sablin, Mikhail V., Dashkovskiy, Petr K., Graphodatsky, Alexander S., Merts, Ilia, Merts, Viktor, Kasparov, Aleksei K., Pitulko, Vladimir V., Onar, Vedat, Öztan, Aliye, Arbuckle, Benjamin S., McColl, Hugh, Renaud, Gabriel, Khaskhanov, Ruslan, Demidenko, Sergey, Kadieva, Anna, Atabiev, Biyaslan, Sundqvist, Marie, Lindgren, Gabriella, López-Cachero, F. Javier, Albizuri, Silvia, Trbojević Vukičević, Tajana, Rapan Papeša, Anita, Burić, Marcel, Rajić Šikanjić, Petra, Weinstock, Jaco, Asensio Vilaró, David, Codina, Ferran, García Dalmau, Cristina, Morer de Llorens, Jordi, Pou, Josep, de Prado, Gabriel, Sanmartí, Joan, Kallala, Nabil, Torres, Joan Ramon, Maraoui-Telmini, Bouthéina, Belarte Franco, Maria-Carme, Valenzuela-Lamas, Silvia, Zazzo, Antoine, Lepetz, Sébastien, Duchesne, Sylvie, Alexeev, Anatoly, Bayarsaikhan, Jamsranjav, Houle, Jean-Luc, Bayarkhuu, Noost, Turbat, Tsagaan, Crubézy, Éric, Shingiray, Irina, Mashkour, Marjan, Berezina, Natalia Ya., Korobov, Dmitriy S., Belinskiy, Andrey, Kalmykov, Alexey, Demoule, Jean-Paul, Reinhold, Sabine, Hansen, Svend, Wallner, Barbara, Roslyakova, Natalia, Kuznetsov, Pavel F., Tishkin, Alexey A., Wincker, Patrick, Kanne, Katherine, Outram, Alan, and Orlando, Ludovic

Published
2024
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3. Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes

Author

Aterido, Adrià, López-Lasanta, María, Blanco, Francisco, Juan-Mas, Antonio, García-Vivar, María Luz, Erra, Alba, Pérez-García, Carolina, Sánchez-Fernández, Simón Ángel, Sanmartí, Raimon, Fernández-Nebro, Antonio, Alperi-López, Mercedes, Tornero, Jesús, Ortiz, Ana María, Fernández-Cid, Carlos Marras, Palau, Núria, Pan, Wenjing, Byrne-Steele, Miranda, Starenki, Dmytro, Weber, Daniel, Rodriguez-Nunez, Ivan, Han, Jian, Myers, Richard M., Marsal, Sara, and Julià, Antonio

Published
2024
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5. Update of the 5 MW Beam-on-Target Requirements for improvement of the materials irradiation performance at IFMIF-DONES

Author

Iván Podadera, Philippe Cara, Irene Álvarez-Castro, Marta Anguiano, Frederik Arbeiter, Santiago Becerril, Davide Bernardi, Jesús Castellanos, Nicolas Chauvin, Tamás Dézsi, Javier Díaz, Almudena Díez, Mario García, Sergej Gordeev, Rebeca Hernández, María Luque, Llorenç Macià, Jorge Maestre, Fernando Mota, Francesco Saverio Nitti, Concepción Oliver, Jin-Hun Park, Dragan Poljak, Cayetano Prieto, Yuefeng Qiu, Daniel Sánchez-Herranz, Manel Sanmartí, Arkady Serikov, Marta Serrano, Tonci Tadic, Marta Ternero, Claudio Torregrosa-Martin, and Ángel Ibarra

Subjects
Particle accelerator, Fusion materials, Nuclear engineering. Atomic power, TK9001-9401
Abstract

IFMIF-DONES is a facility under construction in Granada, whose main goal is the validation and characterization of materials under a fusion prototypic irradiation field. This field is created by the interaction of a high energy intense continuous deuteron beam and a flowing liquid lithium target. The requirements imposed on the beam at the interaction point are a complex trade-off among the scientific experimental needs for the materials irradiation defined at the top-level requirements (20 dpa in a volume of 0.3 dm3 and 50 dpa in 0.1 dm3), and the technical constraints of several systems such as the Accelerator Systems, the Lithium Systems, and the Test Systems. Recent simulations with the initial definition of beam-on-target requirements showed the necessity of redefining them in order to fulfill the irradiation needs. This contribution will address the main challenges to gather the inputs for the definition and reassessment of the beam-on-target requirements. A comparison detailing the main changes compared to the previous ones will be given, together with a short overview of the studies ongoing by different systems to analyze the impact of each beam-on-target requirements on the performance of the whole facility.

Published
2024
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6. A Comparative Numerical Analysis of 3D and 2D Vertical Falling Films

Author

Chen, Yuanxiang, Zheng, Jian, Sanmarti Perona, Oriol, Plana Riu, Josep, Castro González, Jesús, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Tolio, Tullio A. M., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Schmitt, Robert, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Benim, Ali Cemal, editor, Bennacer, Rachid, editor, Mohamad, Abdulmajeed A., editor, Ocłoń, Paweł, editor, Suh, Sang-Ho, editor, and Taler, Jan, editor

Published
2024
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7. A One-Dimensional Model and the Influence of the Mass Flow Rate in a Structured Thermal Energy Storage System for Concentrated Solar Power Plants

Author

Sanmarti, Oriol, Vera, Jordi, Torras, Santiago, Pérez-Segarra, Carlos D., Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Tolio, Tullio A. M., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Schmitt, Robert, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Benim, Ali Cemal, editor, Bennacer, Rachid, editor, Mohamad, Abdulmajeed A., editor, Ocłoń, Paweł, editor, Suh, Sang-Ho, editor, and Taler, Jan, editor

Published
2024
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9. Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes

Author

Adrià Aterido, María López-Lasanta, Francisco Blanco, Antonio Juan-Mas, María Luz García-Vivar, Alba Erra, Carolina Pérez-García, Simón Ángel Sánchez-Fernández, Raimon Sanmartí, Antonio Fernández-Nebro, Mercedes Alperi-López, Jesús Tornero, Ana María Ortiz, Carlos Marras Fernández-Cid, Núria Palau, Wenjing Pan, Miranda Byrne-Steele, Dmytro Starenki, Daniel Weber, Ivan Rodriguez-Nunez, Jian Han, Richard M. Myers, Sara Marsal, and Antonio Julià

Subjects
Biology (General), QH301-705.5, Genetics, QH426-470
Abstract

Abstract Background In rheumatoid arthritis (RA), the activation of T and B cell clones specific for self-antigens leads to the chronic inflammation of the synovium. Here, we perform an in-depth quantitative analysis of the seven chains that comprise the adaptive immune receptor repertoire (AIRR) in RA. Results In comparison to controls, we show that RA patients have multiple and strong differences in the B cell receptor repertoire including reduced diversity as well as altered isotype, chain, and segment frequencies. We demonstrate that therapeutic tumor necrosis factor inhibition partially restores this alteration but find a profound difference in the underlying biochemical reactivities between responders and non-responders. Combining the AIRR with HLA typing, we identify the specific T cell receptor repertoire associated with disease risk variants. Integrating these features, we further develop a molecular classifier that shows the utility of the AIRR as a diagnostic tool. Conclusions Simultaneous sequencing of the seven chains of the human AIRR reveals novel features associated with the disease and clinically relevant phenotypes, including response to therapy. These findings show the unique potential of AIRR to address precision medicine in immune-related diseases.

Published
2024
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11. Clinical and structural damage outcomes in axial spondyloarthritis patients receiving NSAIDs or advanced therapies: a description of a real-life cohort

Author

Anastasia Mocritcaia, Chafik Chacur, C. D. Adao Abe, Ana Belén Azuaga-Piñango, Beatriz Frade-Sosa, Juan C. Sarmiento-Monroy, Lucia Alascio, J. A. Gómez-Puerta, Raimon Sanmartí, Juan D. Cañete, and Julio Ramírez

Subjects
axial spondyloarthritis, NSAIDs, assessment, management, biological therapy, Medicine (General), R5-920
Abstract

IntroductionThis study aims to describe the clinical characteristics, disease activity, and structural damage in patients with axial spondyloarthritis (axSpA) who receive chronic treatment with nonsteroideal anti-inflammatory drugs (NSAIDs) or advanced therapies in a clinical setting.MethodsCross-sectional study on axSpA patients consecutively recruited from the outpatient clinic of a tertiary hospital. We collected data on clinical and demographic characteristics, as well as treatment patterns involving NSAIDs and advanced therapies. Structural damage was assessed using mSASSS.ResultsOverall, data from 193 axSpA patients (83% ankylosing spondylitis) were gathered, with a mean disease duration of 21.4 years. Of these, 85 patients (44%) were exclusively taking NSAIDs, while 108 (56%) were receiving advanced therapies, with TNF inhibitors being the predominant choice (93 out of 108, 86.1%). Among patients using NSAIDs, 64.7% followed an on-demand dosing regimen, while only 17.6% used full doses. Disease activity was low, with a mean BASDAI of 3.1 and a mean ASDAS-CRP of 1.8. In comparison to patients under chronic NSAID treatment, those taking advanced therapies were primarily male (69.4% versus 51.8%, p = 0.025) and significantly younger (mean age of 49 versus 53.9 years, p = 0.033). Additionally, patients on advanced therapies exhibited lower ASDAS-CRP (p = 0.046), although CRP serum levels and BASDAI scores did not differ between the two groups. In the multivariable analysis, therapy (NSAID versus biological treatment) was not independently associated with ASDAS-CRP, BASDAI or mSASSS.ConclusionThis cross-sectional analysis of a real-world cohort of axSpA patients shows positive clinical and radiological outcomes for both NSAIDs and advanced therapies.

Published
2024
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13. Update of the 5 MW Beam-on-Target Requirements for improvement of the materials irradiation performance at IFMIF-DONES

Author

Podadera, Iván, Cara, Philippe, Álvarez-Castro, Irene, Anguiano, Marta, Arbeiter, Frederik, Becerril, Santiago, Bernardi, Davide, Castellanos, Jesús, Chauvin, Nicolas, Dézsi, Tamás, Díaz, Javier, Díez, Almudena, García, Mario, Gordeev, Sergej, Hernández, Rebeca, Luque, María, Macià, Llorenç, Maestre, Jorge, Mota, Fernando, Nitti, Francesco Saverio, Oliver, Concepción, Park, Jin-Hun, Poljak, Dragan, Prieto, Cayetano, Qiu, Yuefeng, Sánchez-Herranz, Daniel, Sanmartí, Manel, Serikov, Arkady, Serrano, Marta, Tadic, Tonci, Ternero, Marta, Torregrosa-Martin, Claudio, and Ibarra, Ángel

Published
2024
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14. Instrumentos de medida como núcleo del proceso de enseñanza-aprendizaje en la formación de maestros

Author

Julià Hinojosa Lobato and Neus Sanmartí Puig

Subjects
formación de maestras, enseñanza, aprendizaje, instrumentos de medida, indagación, stem, Social Sciences
Abstract

En este trabajo se presentan los primeros resultados de una propuesta de enseñanza-aprendizaje en relación con cómo enseñar ciencias partiendo de un instrumento para medir magnitudes y cómo aprenden de forma significativa las alumnas del grado de magisterio. Se pretende que las futuras docentes aprendan ciencia, sobre ciencia y cómo explicar la misma, haciendo y reflexionando sobre en qué está basado un instrumento, su diseño, construcción, y cómo lo aplicamos para indagar. Se promueve una actividad científica indagatoria e ingenieril que a través de la instrumentalización dé importancia a la argumentación y la modelización aplicando procesos de indagación. Se presentan también los primeros resultados basándose en los informes y las reflexiones metacognitivas realizados por las alumnas. Se han identificado algunas dificultades y fortalezas de la metodología.

Published
2024
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15. Synovial tissue features associated with poor prognosis in inflammatory arthritis

Author

Ana Belén Azuaga, Andrea Cuervo, Raquel Celis, Beatriz Frade-Sosa, Juan C. Sarmiento-Monroy, Virginia Ruiz-Esquide, José A. Gómez-Puerta, Raimon Sanmartí, and Julio Ramírez

Subjects
Synovial tissue, Poor prognosis factor, Rheumatoid arthritis, Psoriatic arthritis, Undifferentiated arthritis, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Inflammatory arthritis encompasses a group of immune-mediated diseases characterized by chronic joint inflammation. Despite having pathogenic mechanisms in common, the prognosis of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and undifferentiated arthritis (UA) could be different regarding progression to chronic, to erosive, or to self-limited disease. Our aim was to evaluate the potential association of synovial tissue (ST) inflammatory cell infiltrate, the presence of ectopic lymphoid neogenesis (LN +) structures, and poor prognosis factors (PPF) in patients with RA, PsA, and UA. Methods We conducted a retrospective study including patients with active arthritis (RA, PsA, UA) who had ST obtained by rheumatological arthroscopy or ultrasound-guided biopsy. Clinical, demographic, and immunohistochemical data of the synovium was evaluated. Patients with biological therapy at the time of synovial biopsy were excluded. PPF in patients with RA and UA were defined by the presence of anti-cyclic citrullinated peptide antibodies and/or rheumatoid factor, development of bone erosions, or requirement of biological therapy during the follow-up. PPF in patients with PsA were defined as the presence of high levels of acute-phase reactants (ESR/CRP), dactylitis or nail involvement at the time of biopsy, development of bone erosion, or requirement of biological therapy during the follow-up. Results A total of 88 patients were included: 26 RA, 33 PsA, and 29 UA. All patients were followed up for 5 years after the biopsy. Fourteen (53.84%) RA patients had PPF, and 17 (65.38%) had LN + . LN + was associated with PPF (p 0.038) and biologic therapy initiation (p 0.018). A total of 14 (43.75%) PsA patients had PPF. CD15 infiltrate (410.68 [SD 477.63] cells/mm2) was associated with PPF (p 0.008) in PsA patients. Sixteen (55.17%) patients with UA had PPF, and 13 (44.82%) had LN + . In this group, synovial CD68 + macrophages cells density was negatively correlated with DAS28-CRP (r = − 0.346, p 0.042). Conclusions The presence of LN + and higher CD15 + polymorphonuclear cells infiltrate was associated with PPF in RA and PsA, respectively. No associations were found for UA. These findings suggest a great heterogeneity of the ST features and its pathogenic implications in the subtypes of inflammatory arthritis.

Published
2024
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17. Novel Chimeric Peptides Based on the Enolase Peptide Antigen (CEP-1) Bearing Three Post-Translational Modifications (Citrullination, Homocitrullination and Acetylation) for Determining the Diagnosis and Severity of Rheumatoid Arthritis

Author

María José Gómara, Juan C. Sarmiento-Monroy, Raul Castellanos-Moreira, José A Gómez-Puerta, Raimon Sanmartí, and Isabel Haro

Subjects
rheumatoid arthritis, interstitial lung disease, diagnosis, chimeric peptides, synthetic peptides, fibrin, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

With the aim of improving the uncertainties associated with the correct diagnosis of seronegative rheumatoid arthritis (RA) and identifying those at risk of developing interstitial lung disease (ILD), we have designed new peptide antigens bearing three post-translational modifications (PTMs) (citrulline, homocitrulline and acetyl-lysine) related to RA that could complement existing tests based on anti-citrullinated peptide/protein antibodies (ACPAs). Several chimeric peptides were synthesized and comparatively tested as antigens in ELISAs with two cohorts of sera: 178 RAs and 110 healthy blood donors. The results indicated that although chimeric peptides containing all three PTMs and vimentin and enolase domains do not significantly outperform existing ACPA tests in terms of sensitivity and specificity, they show potential to complement current assays, especially when detecting antibodies in some seronegative patients. Furthermore, the presence of these autoantibodies significantly identified patients with RA and ILD. We can conclude that the identification of specific autoantibody profiles using synthetic antigens containing peptide domains derived from proteins present in the human joint could help in the early detection of the risk of ILD in patients with RA and be useful for adapting follow-up strategies and guiding decisions during treatment.

Published
2024
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18. Impact of an antimicrobial stewardship program indicator on the appropriateness of the empiric antibiotic treatment of urinary source Escherichia coli bacteraemia

Author

Blanco, Naiara Villalba, Vidal, Rafel Pérez, Fernández, Francisco José Vargas-Machuca, de Gracia García Ramírez, Mª, Castro, Ivan Javier, Serra, Natàlia Juan, Satorra, Rosa Maria Morera, Martorell, Sara Oduber, Huerta, Eduardo Sáez, Carrascosa, Montserrat, Soriano, Ludivina Ibañez, Smithson, Alex, Miserachs, Nuria, Blancas, David, Alonso-Tarrés, Carles, Ayuso, Elisabet Farré, González, Maria Priegue, de Ciriza Villacampa, Carmen Pérez, Fernández, María Dolores García, Martins, Marlene Àlvarez, del Río Pérez, Oscar, Riera, Ester Sanfeliu, Bertomeu, Manel Panisello, Flores, Angels García, González, Laura Linares, Pujol, Ester Comellas i, Matias, Guillem Vila, Adell, Claudia Miralles, Marcual, Jaume Llaberia, Sibat, Anna Martinez, Flotats, Elisenda, Roldan, Francina Riu, Martinez, Lorena Gaviria, de Gamarra Martínez, Edurne Fernández, Solchaga, Virginia Pomar, Luque, M. Fernanda Solano, Barque, M. Pilar Barrufet, Nicolas, Elisabeth Mauri, Fidalgo, Arantzazu Mera, Bertran, Nuria Torrellas, Gomila-Grange, Aina, Blasi, Oriol Gasch, Badia, Ester Dorca, Santamaria, Marta Andrés, Pérez-Moreno, Mar Olga, Pallares, Naya Bellaubi, González, Lidia Martín, Fernández, Magda Muelas, Padilla, Eduardo, Zorrilla, Silvia Gomez, Enguidanos, Maria Rosa Laplace, Jofre, Clara Sala, Arango, Mauricio Valencia, Pascua, Pilar Marcos, Chippiraz, Elisabet Lerma, Sureda, Teresa Falgueras, González, Melisa Barrantes, Saballs, Mireia, Taha, Mohamed Sufian Al-dirra, Guitart, Silvia Sancliment, Larrainzar-Coghen, Thais, Toboso, Sebastián Hernández, Rodriguez, Irene Sánchez, Fraile, Maria José, Torras, Sara Garcia, Guitard-Quer, Alba, Castellana-Perelló, Dolors, Sáenz, Alfredo Jover, Ramírez-Hidalgo, María, Pardo, Graciano García, Garriga, Imma Grau, Palau, Damaris Berbel, Moral, Alícia, Vilamala, Anna, Montal, Camil·la Valls, Navarro, Maria, Valls, Mariona Xercavins, Anaya, Gisela Cuadrado, Ochoa, Ivett Suárez, Matellanes, Julen Montoya, Trevisanello, Lucia, Segarra, Glòria Garcia, Prieto, Natacha Recio, Azcona, Ana Felisa Lopez, Iftimie, Simona Mihaella, Jaime, Laura Cabrera, Margall, Nuri Quer, Laporte, Júlia, González, Carlota Gudiol, Sanmartí, Montserrat, Diaz-Brito, Vicens, Belda, Alejandro Sanjuan, Sanz, Marta Milián, Giménez-Pérez, Montserrat, Hernández, Sergi, Padullés, Ariadna, Boix-Palop, Lucía, Grau, Santiago, Badia, Josep M., Ferrer, Ricard, Calbo, Esther, Limón, Enric, Pujol, Miquel, and Horcajada, Juan P.

Published
2024
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20. Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period

Author

Jesús Tornero, Alba Erra, Santos Castañeda, Carolina Pérez-García, Raimon Sanmartí, Sara Marsal, Ingrid Moller, Esperanza Naredo, Miguel A González-Gay, Celia Erausquin, Ivan Castellví, Javier Llorca, Alejandro Muñoz, María Galindo, Enrique Raya, Lydia Abasolo, Gema Bonilla, Alfonso Corrales, Inmaculada Ureña, Carlos Rodríguez-Lozano, Carlos González-Juanatey, Cristina Fernandez Carballido, Francisco J López-Longo, Miguel Ángel González-Gay, Eduardo Collantes, José A Miranda-Filloy, Sagrario Bustabad, Indalecio Monteagudo, Jose A Piqueras, Tatiana Cobo, Joan Maymó, Carmen Barbadillo, Soledad Ojeda, Jaime Calvo Alen, Antonio Fernandez Nebro, Isabel Rodríguez, Pilar Font, Martina Steiner, Eugenio Chamizo Carmona, Beatriz González Álvarez, Santiago Munoz, Joan M Nolla, Fernando Sánchez-Alonso, Julio Sanchez, Raul Menor Almagro, Ana Pérez Gómez, Monica Ibañez, Elena Heras-Recuero, Trinidad Pérez Sandoval, Miren Uriarte-Ecenarro, Angela Pecondón, Hye Sang Park, Jessica Polo y La Borda, Zulema Plaza, Carmen García Gómez, Ivan Ferraz-Amaro, Jesús Tomás Sanchez-Costa, Olga Carmen Sánchez-González, Ana Isabel Turrión-Nieves, Ana Perez-Alcalá, José L FernándezSueiro, José A Pinto-Tasende, Eugenia Gonzálezde Rábago, María J González-Fernández, Ramón Huguet Codina, Beatriz Yoldi, Mercedes Ramentol, Gabriela Ávila, Cayetano Alegre, Fernando Gamero, José García Torón, María P Moreno-Gil, Antonio Juan-Mas, Pilar Espiño, Inmaculada Ros, Horacio Berman, Oscar Fontseré Patón, Benjamín Fernández Gutiérrez, José M Pina-Salvador, María D Fábregas, Montserrat Romera, Jesús A García-Vadillo, Rosario García de Vicuña, María A Belmonte, María V Irigoyen, Olga Martínez González, Rebeca Belmonte Gómez, Pastora Granados Bautista, Azucena Hernández Sanz, José Santos Rey, Carmen O Sánchez-González, Javier Bachiller, Antonio Zea, Francisco J Manero, Chesús Beltrán Audera, Marta Medrano, Jesús Babío Herráez, Javier del Pino, Ruth López González, María Enriqueta Peiró, José M Senabre, José C Rosas, Isabel Rotés, Estefanía Moreno, Javier Calvo, Amalia Rueda, Pilar Morales, Ana Nieto, Ana Ruibal Escribano, Sergio Ros Expósito, Ginés Sánchez Nievas, Enrique Júdez Navarro, Manuela Sianes Fernández, Silvia Martínez Pardo, Manel Pujol, Alberto Cantabrana, Esmeralda Delgado, Sergio Rodríguez Montero, Javier Rivera Redondo, Teresa González Hernández, Francisco J González-Polo, José M Moreno, Emilio Giner Serret, Laura Cebrián Méndez, María Teresa Navío, Teresa Pedraz Penalva, Encarnación Pagán, Pablo Mesadel Castillo, Ana Cruz, Ana Turrión, Desireé Ruíz, Antonio López Meseguer, Manuel J Moreno, Luis F Linares, Mercedes Morcillo, María L González-Gómez, José M Aramburu, Natalia A Rivera, Olaia Fernández Berrizbeitia, Manel Riera, Yolanda María León, Miriam Amirall, Jordi Fiter, Julia Fernández Melón, Luis Espadaler, Joaquín Belzunegui, Inmaculada Bañegil, César Díaz, Ramón Valls, María Bonet, Eva Revuelta Evrard, Javier R Godo, and José A González-Fernández

Subjects
Medicine
Abstract

Objective To assess the predictive value of four cardiovascular (CV) risk algorithms for identifying high-risk psoriatic arthritis (PsA) patients.Methods Evaluation of patients with PsA enrolled in the Spanish prospective project CARdiovascular in RheuMAtology. Baseline data of 669 PsA patients with no history of CV events at the baseline visit, who were followed in rheumatology outpatient clinics at tertiary centres for 7.5 years, were retrospectively analysed to test the performance of the Systematic Coronary Risk Assessment (SCORE), the modified version (mSCORE) European Alliance of Rheumatology Associations (EULAR) 2015/2016, the SCORE2 algorithm (the updated and improved version of SCORE) and the QRESEARCH risk estimator version 3 (QRISK3).Results Over 4790 years of follow-up, there were 34 CV events, resulting in a linearised rate of 7.10 per 1000 person-years (95% CI 4.92 to 9.92). The four CV risk scales showed strong correlations and all showed significant associations with CV events (p

Published
2024
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21. El tractament postexcavació de les restes constructives

Author

ÁLVAREZ ARZA, RAMON, primary, ASENSIO VILARÓ, DAVID, additional, BELARTE FRANCO, MARIA DEL CARMEN, additional, JORNET I NIELLA, RAFEL, additional, LÓPEZ-REYES, DAVID, additional, MORER, JORDI, additional, NOGUERA GUILLÉN, JAUME, additional, POU, JOSEP, additional, REVILLA CALVO, VÍCTOR, additional, SANMARTÍ GREGO, JOAN, additional, SANTACANA MESTRE, JOAN, additional, and VALENZUELA LAMAS, SÍLVIA, additional

Published
2023
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22. Conclusions. Le site d’Alorda Park dans le cadre de la dynamique historique de l’Âge du fer sur la côte centre-sud de la Catalogne

Author

ÁLVAREZ ARZA, RAMON, primary, ASENSIO VILARÓ, DAVID, additional, BELARTE FRANCO, MARIA DEL CARMEN, additional, JORNET I NIELLA, RAFEL, additional, LÓPEZ-REYES, DAVID, additional, MORER, JORDI, additional, NOGUERA GUILLÉN, JAUME, additional, POU, JOSEP, additional, REVILLA CALVO, VÍCTOR, additional, SANMARTÍ GREGO, JOAN, additional, SANTACANA MESTRE, JOAN, additional, and VALENZUELA LAMAS, SÍLVIA, additional

Published
2023
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23. Dinàmica estratigràfica i evolució del jaciment

Author

ÁLVAREZ ARZA, RAMON, primary, ASENSIO VILARÓ, DAVID, additional, BELARTE FRANCO, MARIA DEL CARMEN, additional, JORNET I NIELLA, RAFEL, additional, LÓPEZ-REYES, DAVID, additional, MORER, JORDI, additional, NOGUERA GUILLÉN, JAUME, additional, POU, JOSEP, additional, REVILLA CALVO, VÍCTOR, additional, SANMARTÍ GREGO, JOAN, additional, SANTACANA MESTRE, JOAN, additional, and VALENZUELA LAMAS, SÍLVIA, additional

Published
2023
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24. Descripció general i evolució estructural de l’assentament. El desenvolupament de la recerca

Author

ÁLVAREZ ARZA, RAMON, primary, ASENSIO VILARÓ, DAVID, additional, BELARTE FRANCO, MARIA DEL CARMEN, additional, JORNET I NIELLA, RAFEL, additional, LÓPEZ-REYES, DAVID, additional, MORER, JORDI, additional, NOGUERA GUILLÉN, JAUME, additional, POU, JOSEP, additional, REVILLA CALVO, VÍCTOR, additional, SANMARTÍ GREGO, JOAN, additional, SANTACANA MESTRE, JOAN, additional, and VALENZUELA LAMAS, SÍLVIA, additional

Published
2023
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25. Conclusions. L’assentament d’Alorda Park dins de la dinàmica històrica de l’edat del ferro a la costa centremeridional de Catalunya

Author

ÁLVAREZ ARZA,, RAMON, primary, ASENSIO VILARÓ, DAVID, additional, BELARTE FRANCO, MARIA DEL CARMEN, additional, JORNET I NIELLA, RAFEL, additional, LÓPEZ-REYES, DAVID, additional, MORER, JORDI, additional, NOGUERA GUILLÉN, JAUME, additional, POU, JOSEP, additional, REVILLA CALVO, VÍCTOR, additional, SANMARTÍ GREGO, JOAN, additional, SANTACANA MESTRE, JOAN, additional, and VALENZUELA LAMAS, SÍLVIA, additional

Published
2023
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26. Assessment of anti-malondialdehyde-acetaldehyde antibody frequencies in rheumatoid arthritis with new data from two independent cohorts, meta-analysis, and meta-regression

Author

Lorena Rodriguez-Martinez, Cristina García-Moreno, Eva Perez-Pampin, María J. Gómara, Juan C. Sarmiento-Monroy, Yolanda Lopez-Golán, José A. Gómez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmartí, Isabel Haro, and Antonio González

Subjects
Rheumatoid arthritis, Autoantibodies, Biomarker, Post-translational modifications, Heterogeneity, Meta-analysis, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Autoantibodies are critical elements in RA pathogenesis and clinical assessment. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies are potentially useful because of their claimed high sensitivity for all RA patients, including those lacking RF and anti-CCP antibodies. Therefore, we aimed to replicate these findings. Methods We independently attempted replication in Santiago and Barcelona using sera from 517 and 178 RA patients and 272 and 120 healthy controls, respectively. ELISA protocols for anti-MAA antibodies included five antigens (human serum albumin in three formulations, fibrinogen, and a synthetic peptide) and assays for the IgG, IgM, and IgA isotypes. We integrated our results with information found by searching the Web of Science for reports of anti-MAA antibodies in RA. The available patients (4989 in 11 sets) were included in a meta-analysis aimed at heterogeneity between studies. Factors accounting for heterogeneity were assessed with meta-regression. Results The sensitivity of anti-MAA antibodies in our RA patients was low, even in seropositive patients, with the percentage of positives below 23% for all ELISA conditions. Our results and bibliographic research showed IgG anti-MAA positive patients ranging from 6 to 92%. The extreme between-studies heterogeneity could be explained (up to 43%) in univariate analysis by sex, African ethnicity, the site of study, or recruitment from the military. The best model, including African ancestry and smoking, explained a high heterogeneity fraction (74%). Conclusion Anti-MAA antibody sensitivity is extremely variable between RA patient collections. A substantial fraction of this variability cannot be attributed to ELISA protocols. On the contrary, heterogeneity is determined by complex factors that include African ethnicity, smoking, and sex.

Published
2023
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28. Axial Disease in Psoriatic Arthritis: A Challenging Domain in Clinical Practice

Author

Lucía Alascio, Ana Belén Azuaga-Piñango, Beatriz Frade-Sosa, Juan C. Sarmiento-Monroy, Andrés Ponce, Sandra Farietta, Jose A. Gómez-Puerta, Raimon Sanmartí, Juan D. Cañete, and Julio Ramírez

Subjects
psoriatic arthritis, spondyloarthritis, biological therapy, Medicine (General), R5-920
Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory condition affecting about one-third of individuals with psoriasis. Defining axial involvement in PsA (axPsA) remains debated. While rheumatologists guide clinical practice, consensus on axPsA is still lacking. This paper explores historical and upcoming definitions from the Axial Involvement in Psoriatic Arthritis (AXIS) study, which aims to establish a validated axPsA definition. Epidemiological data reveal diverse axPsA prevalence rates, emphasizing its complex relationship with peripheral arthritis and enthesitis. Unique genetic, clinical, and radiological features differentiate axPsA from ankylosing spondylitis (AS), necessitating refined classification criteria. The recommendations from the Assessment of Spondylarthritis international Society (ASAS) provide valuable guidance due to the limited direct evidence. Emerging therapies, including interleukin-23 (IL-23) inhibitors or Janus kinase (JAK) inhibitors, are under investigation for axPsA. Currently, secukinumab, an interleukin-17 (IL-17) inhibitor, is an evidence-based option for axPsA management. However, given the variability in individual patient responses and disease manifestations, personalized, evidence-based treatment approaches remain essential for optimizing patient outcomes. In the final section, two real-life cases illustrate the challenges in managing axPsA, emphasizing the importance of tailored therapies. Achieving precision in defining axPsA remains a formidable task, making detailed criteria essential for effective strategies and improving patient outcomes.

Published
2024
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29. Evaluating the extent and impact of the extreme Storm Gloria on Posidonia oceanica seagrass meadows

Author

Marco-Méndez, Candela, Marbà, Núria, Amores, Ángel, Romero, Javier, Minguito-Frutos, Mario, García, María, Pagès, Jordi F., Prado, Patricia, Boada, Jordi, Sánchez-Lizaso, José Luis, Ruiz, Juan Manuel, Muñoz-Ramos, Gregori, Sanmartí, Neus, Mayol, Elvira, Buñuel, Xavier, Bernardeau-Esteller, Jaime, Navarro-Martinez, Pedro Clemente, Marín-Guirao, Lázaro, Morell, Carlos, Wesselmann, Marlene, Font, Rita, Hendriks, Iris E., Seglar, Xavier, Camps-Castella, Judith, Bonfill, Eli, Requena-Gutiérrez, Aurora, Blanco-Murillo, Fabio, Aguilar-Escribano, Javier, Jimenez-Gutierrez, Santiago, Martínez-Vidal, Joaquín, Guillén, Juan Eduardo, Cefalì, Maria Elena, Pérez, Marta, Marcos, Marta, and Alcoverro, Teresa

Published
2024
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31. Autoras inglesas publicadas durante el Franquismo. Jane Austen, Mary Shelley, Charlotte Brontë, George Eliot y Anne Brontë

Author

Caterina Riba and Carme Sanmartí

Subjects
Jane Austen, Mary Shelley, Charlotte Brontë, Anne Brontë, George Eliot, Franquismo, History of scholarship and learning. The humanities, AZ20-999, Philology. Linguistics, P1-1091, Language. Linguistic theory. Comparative grammar, P101-410
Abstract

Este artículo analiza la recepción de cinco autoras inglesas del siglo xix, Jane Austen, Mary Shelley, Charlotte Brontë, George Eliot y Anne Brontë, traducidas al español y publicadas en España durante la época franquista. El estudio se centra en las diez novelas de estas escritoras que superaron la rigurosa censura administrativa y se publicaron por primera vez entre 1939 y 1975: Sense and Sensibility, Mansfield Park y Emma de Jane Austen; The Professor, Shirley y Villette de Charlotte Brontë; Agnes Grey y The Tenant of Wildfell Hall de Anne Brontë; Janet’s Repentance de George Eliot, y Frankenstein de Mary Shelley. Para elucidar los motivos que llevaron a la censura a autorizar la publicación de estas autoras de tradición protestante, se han examinado todos los expedientes de censura referentes a los libros tratados (49 expedientes) y se han tenido en cuenta las valoraciones de los catálogos morales que circulaban durante el franquismo. También se ha llevado a cabo un análisis comparativo en traducciones para verificar si se produjeron transformaciones significativas en el proceso de traducción. La censura fue muy laxa con las autoras analizadas y las novelas se publicaron sin muchos reparos.

Published
2024
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35. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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36. The hidden side of infective endocarditis: Diagnostic and management of 500 consecutive cases in noncardiac surgery centers (2009–2018)

Author

Miró, Jose M., Ambrosioni, Juan, Hernández-Meneses, Marta, Téllez, Adrian, Pericàs, Juan M., Dahl, Anders, Moreno, Asuncion, Aguilar, Sergi, López, Alba, García de la Mària, Cristina, Cañas-Pacheco, María Alejandra, García-González, Javier, Almela, Manel, Zboromyrska, Yuliya, Casals, Climent, Morales, Francisco-Javier, Bosch, Jordi, Marco, Francesc, Vila, Jordi, Quintana, Eduard, Sandoval, Elena, Paré, Juan C., Falces, Carlos, Pereda, Daniel, Cartañá, Ramon, Ninot, Salvador, Azqueta, Manel, Sitges, Marta, Vidal, Barbara, Pomar, José L., Castella, Manuel, Tolosana, José M., Regueiro, Anders, Ortiz, José, Fita, Guillermina, Rovira, Irene, Perissinotti, Andrés, Fuster, David, Ramírez, Jose, Brunet, Mercè, Soy, Dolors, Castro, Pedro, Nicolás, David, Llopis, Jaume, Calzado, Sonia, Gasch, Oriol, Gomila-Grange, Aina, Pedrosa, Marc, Alguacil, Marina, Sanfeliu, Isabel, Guillaumet, Eva, Guillamon, Laura, Caresia, Ana Paula, Díaz, Emilio, Boix-Palop, Lucía, Dietl, Beatriz, Gisbert, Laura, Calbo, Esther, Xercavins, Mariona, Ibars, Sonia, Trenado, Josep, de los Ríos, Javier Díez, Reynaga, Esteban Alberto, Navarro, María, Montserrat, Silvia, Robles, Rocío, Cuquet, Jordi, Arrieta, Itziar, Costa, Núria, Martí, Carmina, Pulido, Ángeles, Ayats, Montserrat, Garro, Pau, Esquirol, Xavier, Bustamante, Marco A., Sanmartí, Montserrat, Cárdenas, Antonio, García, Gloria, Andrés, Marta, García, María Consuelo, Hanacsek, Carme Agustí, Dorca, Esther, Ortiz, María, Roca, Juan Manuel, Mollet, Fundació Sanitària, Tricas, José Maria, Maur, Elisabet, Romeo, Isabel, Vidal-Galve, Rosa, García, Xelo, Agustí, Carme, Tricas, José M., Díez de los Ríos, Javier, and Miró, José M.

Published
2023
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37. Natural lighting performance of vernacular architecture, case study oldtown Pasa, Ecuador

Author

Darío Bustán-Gaona, Manuel Ayala-Chauvin, Jorge Buele, Patricia Jara-Garzón, and Genís Riba-Sanmartí

Subjects
Vernacular architecture, Domestic energy consumption, Natural lighting levels, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Vernacular architecture is an architectural style that reflects the traditions and cultural aspects of a particular region or community. It is characterized by the use of local materials and traditional construction techniques, adapting to the climatic, geographical, and cultural conditions of the place. Despite extensive research on the benefits of natural lighting in modern architecture, there is limited understanding of how vernacular architecture integrates natural lighting principles in various climatic conditions, mainly due to restrictions in intervention and concerns about structural integrity. In today's world, energy efficiency and conservation are crucial aspects of building design. Therefore, this study aims to analyze the effectiveness of natural lighting in the indoor spaces of vernacular architecture. The research includes measurements taken in traditional buildings in the parish of Pasa, Ambato, Ecuador, as well as simulations to evaluate the behavior of sunlight. The findings reveal that, with new construction technologies, lighting levels in the interior spaces of these buildings can be improved. To address this issue, a proposed solution is presented to optimize the use of natural light, resulting in an increase from 30 to 100 lx. This improvement could pave the way for the implementation of policies that enhance the quality of life for users.

Published
2023
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38. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS eventsResearch in context

Author

Javier Martínez-Sanz, Jorge Díaz-Álvarez, Marta Rosas, Raquel Ron, José Antonio Iribarren, Enrique Bernal, Félix Gutiérrez, Andrés Ruiz Sancho, Noemi Cabello, Julián Olalla, Santiago Moreno, Sergio Serrano-Villar, Inma Jarrín, David Dalmau, M. Luisa Navarro, M. Isabel González, Federico Garcia, Eva Poveda, Jose Antonio Iribarren, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M. Ángeles Muñoz-Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Elba Mauleón, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García, Iván Agea, José Sánchez-Payá, Juan Carlos Rodríguez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrus, Verónica Pérez, Julia Portilla, Juan Luís Gómez, Jehovana Hernández, Ana López Lirola, Dácil García, Felicitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, M. Remedios Alemán, Víctor Asensi, María Eugenia Rivas Carmenado, Tomás Suarez-Zarracina, Federico Pulido, Otilia Bisbal, M. Asunción Hernando, David Rial, María de Lagarde, Octavio Arce, Adriana Pinto, Laura Bermejo, Mireia Santacreu, Roser Navarro, Candela Gonzalez, M. José Aramburu, Xabier Camino, Miguel Ángel von Wichmann, Miguel Ángel Goenaga, M. Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Lourdes Martínez, Catalina Robledano, Mar Masiá, Sergio Padilla, Araceli Adsuar, Rafael Pascual, Marta Fernández, Antonio Galiana, José Alberto García, Xavier Barber, Vanessa Agullo, Javier Garcia Abellán, Reyes Pascual, Guillermo Telenti, Lucia Guillén, Ángela Botella, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Isabel Gutierrez, Juan Carlos López, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldamiz-Echevarría, Francisco Tejerina, Cristina Diez, Leire Pérez, Chiara Fanciulli, Saray Corral, Anna Martí, Joaquín Peraire, Consuelo Viladés, Montserrat Vargas, Montserrat Olona, Anna Rull, Verónica Alba, Elena Yeregui, Jenifer Masip, Graciano García-Pardo, Frederic Gómez Bertomeu, Sonia Espineira, Marta Montero, Sandra Cuéllar, Marino Blanes, María Tasias, Eva Calabuig, Miguel Salavert, Juan Fernández, Inmaculada Segarra, Juan González-García, Ana Delgado, Francisco Arnalich, José Ramón Arribas, Jose Ignacio Bernardino, Juan Miguel Castro, Luis Escosa, Pedro Herranz, Victor Hontañón, Silvia García-Bujalance, Milagros García, Alicia González-Baeza, M. Luz Martín-Carbonero, Mario Mayoral, M. Jose Mellado, Rafael Esteban, Rocío Montejano, M. Luisa Montes, Victoria Moreno, Ignacio Pérez-Valero, Berta Rodés, Guadalupe Rúa, Talía Sainz, Elena Sendagorta, Eulalia Valencia, Carmen Busca, Joanna Cano, Julen Cardiñanos, Rosa de Miguel, Jose Ramón Blanco, Laura Pérez-Martínez, José Antonio Oteo, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Piedad Arazo, Gloria Sampériz, Marina Martinez, Angels Jaén, Montse Sanmartí, Mireia Cairó, Javier Martinez-Lacasa, Pablo Velli, Roser Font, Mariona Xercavins, Noemí Alonso, Francesco Aiello, María Rivero, Beatriz Piérola, Maider Goikoetxea, María Gracia, Carlos Ibero, Estela Moreno, Jesús Repáraz, Gemma Navarro, Manel Cervantes Garcia, Sonia Calzado Isbert, Marta Navarro Vilasaro, Belen Lopez Garcia, Ignacio de los Santos, Alejandro de los Santos, Jesús Sanz, Lucio García-Fraile, Enrique Martín, Ildefonso Sánchez-Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, Santos del Campo, José Luis Casado, Fernando Dronda, Ana Moreno, M. Jesús Pérez, Sergio Serrano, Ma Jesús Vivancos, Alejandro Vallejo, Matilde Sanchez, Jose Antonio Pérez-Molina, José Manuel Hermida, Antonia Alcaraz, Joaquín Bravo, Ángeles Muñoz, Cristina Tomás, Mónica Martínez, M. Carmen Villalba, Federico García, Clara Martínez, José Hernández, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Jorge Del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Antonio Antela, Elena Losada, Melchor Riera, María Peñaranda, M. Angels Ribas, Antoni A. Campins, Mercedes Garcia-Gazalla, Francisco J. Fanjul, Javier Murillas, Francisco Homar, Helem H. Vilchez, Luisa Martin, Antoni Payeras, Jesús Santos, María López, Crisitina Gómez, Isabel Viciana, Rosario Palacios, Luis Fernando López-Cortés, Nuria Espinosa, Cristina Roca, Silvia Llaves, Juan Manuel Tiraboschi, Arkaitz Imaz, Ana Karina Silva, María Saumoy, Sofía Catalina Scévola, Adrián Curran, Vicenç Falcó, Jordi Navarro, Joaquin Burgos, Paula Suanzes, Jorge García, Vicente Descalzo, Patricia Álvarez, Bibiana Planas, Marta Sanchiz, Lucía Rodríguez, M José Sánchez, Javier Pérez, Alfonso del Arco, Javier de la Torre, José Luis Prada, Onofre Juan Martínez, Lorena Martinez, Francisco Jesús Vera, Josefina García, Begoña Alcaraz, Antonio Jesús Sánchez Guirao, Alvaro Mena, Angeles Castro, Berta Pernas, Pilar Vázquez, Soledad López, Sofía Ibarra, Guillermo García, Josu Mirena, Oscar Luis Ferrero, Josefina López, M. Mar Cámara, Mireia de la Peña, Miriam Lopez, Iñigo Lopez, Itxaso Lombide, Victor Polo, Joana de Miguel, Carlos Galera, Marian Fernández, Helena Albendin, Antonia Castillo, Asunción Iborra, Antonio Moreno, M. Angustias Merlos, Asunción Vidal, Concha Amador, Francisco Pasquau, Concepcion Gil, Jose Tomás Algado, Inés Suarez-García, Eduardo Malmierca, Patricia González-Ruano, M. Pilar Ruiz, José Francisco Pascual, Elena Sáez, Luz Balsalobre, M. Villa López, Mohamed Omar, Carmen Herrero, M. Amparo Gómez, Miguel Alberto de Zarraga, Desiré Pérez, Vicente Estrada, Nieves Sanz, Noemí Cabello, Jorge Vergas García, Maria Jose Núñez, Iñigo Sagastagoitia, Miguel Górgolas, Alfonso Cabello, Beatriz Álvarez, Laura Prieto, Irene Carrillo, José Sanz, Alberto Arranz, Cristina Hernández, María Novella, M. José Galindo, Ana Ferrer, Antonio Rivero Román, Inma Ruíz, Antonio Rivero Juárez, Pedro López, Isabel Machuca, Mario Frias, Ángela Camacho, Ignacio Pérez, Diana Corona, Miguel Cervero, Rafael Torres, Juan Antonio Pineda, Pilar Rincón, Juan Macías, Luis Miguel Real, Anais Corma, Alejandro Gonzalez-Serna, Alexandre Pérez, Luis Morano, Celia Miralles, Antonio Ocampo, Guillermo Pousada, Lucía Patiño, Carlos Dueñas, Sara Gutiérrez, Elena Tapia, Cristina Novoa, Xjoylin Egües, and Pablo Telleria

Subjects
HIV, Non-AIDS events, Neoplasia, Cardiovascular event, CD4/CD8 ratio, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: While a low CD4/CD8 ratio during HIV treatment correlates with immunosenescence, its value in identifying patients at an increased risk for clinical events remains unclear. Methods: We analyzed data from the CoRIS cohort to determine whether CD4 count, CD8 count, and CD4/CD8 ratio at year two of antiretroviral therapy (ART) could predict the risk of serious non-AIDS events (SNAEs) during the next five years. These included major adverse cardiovascular events, non-AIDS-defining malignancies, and non-accidental deaths. We used pooled logistic regression with inverse probability weighting to estimate the survival curves and cumulative risk of clinical events. Findings: The study included 4625 participants, 83% male, of whom 200 (4.3%) experienced an SNAE during the follow-up period. A CD4/CD8 ratio

Published
2023
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39. Iron age genomic data from Althiburos – Tunisia renew the debate on the origins of African taurine cattle

Author

Ginja, Catarina, Guimarães, Silvia, da Fonseca, Rute R., Rasteiro, Rita, Rodríguez-Varela, Ricardo, Simões, Luciana G., Sarmento, Cindy, Belarte, Maria Carme, Kallala, Nabil, Torres, Joan Ramon, Sanmartí, Joan, Arruda, Ana Margarida, Detry, Cleia, Davis, Simon, Matos, José, Götherström, Anders, Pires, Ana Elisabete, and Valenzuela-Lamas, Silvia

Published
2023
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40. Overview of IFMIF-DONES diagnostics: Requirements and techniques

Author

Torregrosa-Martin, C., Ibarra, A., Aguilar, J., Ambi, F., Arranz, F., Arbeiter, F., Bagnasco, A., Becerril, S., Bernardi, D., Bolzon, B., Botta, E., Brenneis, B., Cappelli, M., Cara, P., Castellanos, J., Cosic, D., De la Morena, C., Diez, A., Ericsson, G., García, A., García, M., Garcinuño, B., Gutiérrez, J., Gutiérrez, V., Jimenez-Rey, D., Dezsi, T., Ferreira, M. Juni, Fiore, S., Krolas, W., Lorenzo, R., Luque, M., Maciá, L., Marroncle, J., Martin-Fuertes, F., Marugán, J.C., Maestre, J., Meléndez, C., Miccichè, G., Mollá, J., Moreno, A., Nitti, F.S., Núñez, C., Ogando, F., Pinna, T., Oliver, C., Podadera, I., Prieto, C., Prokopowicz, R., Qiu, Y., Rapisarda, D., Regidor, D., Rodríguez, E., Sabogal, A., Sánchez-Herranz, D., Sanmarti, M., Seguí, L., Serikov, A., Tadić, T., Talarowska, A., Wiacek, U., Weber, M., Valenzuela, J., and Zsakai, A.

Published
2023
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42. Low-Cost Energy Consumption Monitoring System Using NodeMCU

Author

Ayala-Chauvín, Manuel, Acurio-Pérez, Joel Andrés, Sanmartí, Genís Riba, Buele, Jorge, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Valencia-García, Rafael, editor, Bucaram-Leverone, Martha, editor, Del Cioppo-Morstadt, Javier, editor, Vera-Lucio, Néstor, editor, and Jácome-Murillo, Emma, editor

Published
2022
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44. Iron age genomic data from Althiburos – Tunisia renew the debate on the origins of African taurine cattle

Author

Catarina Ginja, Silvia Guimarães, Rute R. da Fonseca, Rita Rasteiro, Ricardo Rodríguez-Varela, Luciana G. Simões, Cindy Sarmento, Maria Carme Belarte, Nabil Kallala, Joan Ramon Torres, Joan Sanmartí, Ana Margarida Arruda, Cleia Detry, Simon Davis, José Matos, Anders Götherström, Ana Elisabete Pires, and Silvia Valenzuela-Lamas

Subjects
Biological sciences, Omics, Genomics, Paleobiology, Paleogenetics, Science
Abstract

Summary: The Maghreb is a key region for understanding the dynamics of cattle dispersal and admixture with local aurochs following their earliest domestication in the Fertile Crescent more than 10,000 years ago. Here, we present data on autosomal genomes and mitogenomes obtained for four archaeological specimens of Iron Age (∼2,800 cal BP–2,000 cal BP) domestic cattle from the Eastern Maghreb, i.e. Althiburos (El Kef, Tunisia). D-loop sequences were obtained for an additional eight cattle specimens from this site. Maternal lineages were assigned to the elusive R and ubiquitous African-T1 haplogroups found in two and ten Althiburos specimens, respectively. Our results can be explained by post-domestication hybridization of Althiburos cattle with local aurochs. However, we cannot rule out an independent domestication in North Africa considering the shared ancestry of Althiburos cattle with the pre-domestic Moroccan aurochs and present-day African taurine cattle.

Published
2023
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45. Mapes de progressió per educar a favor d'una nova cultura de l'aigua

Author

Alba Castelltort Valls and Neus Sanmartí Puig

Subjects
mapes de progressió, aigua, cicle natural, cicle urbà, educació ambiental, Education
Abstract

L’emergència climàtica ja té uns efectes importants sobre els recursos hídrics del nostre territori fet que es fa urgent i necessari educar a favor d’una nova cultura ambiental de l’aigua. L’article presenta tres mapes de progressió que poden ajudar a professorat i educadors/es ambientals a organitzar situacions d’ensenyament-aprenentatge que promouen un aprenentatge més profund. Els mapes, que s’han elaborat a partir d’una recerca educativa, s’organitzen a partir de preguntes ordenades segons el nivell de complexitat i identifiquen les idees-claus que permeten donar resposta a cada pregunta així com expressions que el professorat pot utilitzar per fer-les més comprensibles. També, s’hi destaquen els continguts més complexes o que afavoreixen la visibilització dels vincles entre l’aigua i l’energia.

Published
2023
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46. Una avaluació sense qualificacions al batxillerat: una estratègia per potenciar la regulació dels aprenentatges

Author

Jordi Rull Pallares and Neus Sanmartí Puig

Subjects
Autoregulació, feedback, indicadors, qualificació, batxillerat, química, Education
Abstract

En aquest article s’exposa i analitza l’experiència realitzada durant un curs de 2n de batxillerat de la matèria de química on es van eliminar les qualificacions durant el procés d'aprenentatge per tal de promoure una avaluació que potenciï l’autoregulació de l’alumnat, incrementi la motivació per aprendre i promogui un autoconcepte positiu dels estudiants, amb la finalitat no només de millorar els resultats acadèmics sinó també de canviar la concepció que tenen els alumnes sobre què significa aprendre i com s’aprèn millor.

Published
2023
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47. Retention of subcutaneous abatacept for the treatment of rheumatoid arthritis: real-world results from the ASCORE study: an international 2-year observational study

Author

Alten, Rieke, Mariette, Xavier, Flipo, René-Marc, Caporali, Roberto, Buch, Maya H., Patel, Yusuf, Marsal, Sara, Sanmartí, Raimon, Nurmohamed, Michael T., Griffiths, Hedley, Peichl, Peter, Bannert, Bettina, Chartier, Melanie, Connolly, Sean E., Lozenski, Karissa, and Rauch, Christiane

Published
2022
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49. Nutrient conditions determine the strength of herbivore‐mediated stabilizing feedbacks in barrens

Author

Laia Illa‐López, Àlex Aubach‐Masip, Teresa Alcoverro, Giulia Ceccherelli, Luigi Piazzi, Periklis Kleitou, Jorge Santamaría, Jana Verdura, Neus Sanmartí, Elvira Mayol, Xavi Buñuel, Mario Minguito‐Frutos, Fabio Bulleri, and Jordi Boada

Subjects
alternative stable states, environmental conditions, feedbacks, herbivory, limpets, marine forests, Ecology, QH540-549.5
Abstract

Abstract Abiotic environmental conditions can significantly influence the way species interact. In particular, plant–herbivore interactions can be substantially dependent on temperature and nutrients. The overall product of these relationships is critical for the fate and stability of vegetated ecosystems like marine forests. The last few decades have seen a rapid spread of barrens on temperate rocky reefs mainly as a result of overgrazing. The ecological feedbacks that characterize the barren state involve a different set of interactions than those occurring in vegetated habitats. Reversing these trends requires a proper understanding of the novel feedbacks and the conditions under which they operate. Here, we explored the role of a secondary herbivore in reinforcing the stability of barrens formed by sea urchin overgrazing under different nutrient conditions. Combining comparative and experimental studies in two Mediterranean regions characterized by contrasting nutrient conditions, we assessed: (i) if the creation of barren areas enhances limpet abundance, (ii) the size‐specific grazing impact by limpets, and (iii) the ability of limpets alone to maintain barrens. Our results show that urchin overgrazing enhanced limpet abundance. The effects of limpet grazing varied with nutrient conditions, being up to five times more intense under oligotrophic conditions. Limpets were able to maintain barrens in the absence of sea urchins only under low‐nutrient conditions, enhancing the stability of the depauperate state. Overall, our study suggests a greater vulnerability of subtidal forests in oligotrophic regions of the Mediterranean and demonstrates the importance of environment conditions in regulating feedbacks mediated by plant–herbivore interactions.

Published
2023
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