Search

Your search keyword '"Sankethguddad S"' showing total 13 results
Start Over Author "Sankethguddad S"
13 results on '"Sankethguddad S"'

5. Prevalence of oromucosal lesions in relation to tobacco habit among a Western Maharashtra population

Author

Kamala, K., Sankethguddad, S., Nayak, Ajay, Sanade, Abhijeet, and Rani, S. Ashwini

Subjects
Smoking cessation -- Usage, Prevalence studies (Epidemiology) -- Analysis, Tobacco habit -- Health aspects, Oral health -- Analysis, Radiology, Health
Abstract

Byline: K. Kamala, S. Sankethguddad, Ajay. Nayak, Abhijeet. Sanade, S. Ashwini Rani OBJECTIVES: This study was conducted to determine the number and types of oromucosal lesions (OMLs) in relation to [...]

Published
2019

6. Burning mouth syndrome

Author

Kamala, K., Sankethguddad, S., Sujith, S., and Tantradi, Praveena

Subjects
Burning mouth syndrome -- Physiological aspects, Health
Abstract

Byline: K. Kamala, S. Sankethguddad, S. Sujith, Praveena. Tantradi Burning mouth syndrome (BMS) is multifactorial in origin which is typically characterized by burning and painful sensation in an oral cavity [...]

Published
2016

13. P53 and Ki67 Biomarkers are Predictors for Malignant Transformation in Oral Submucous Fibrosis: A Prospective Study.

Author

Kamala KA and Sankethguddad S

Subjects
Humans, Female, Male, Prospective Studies, Adult, Prognosis, Case-Control Studies, Middle Aged, Follow-Up Studies, Precancerous Conditions metabolism, Precancerous Conditions pathology, Young Adult, Oral Submucous Fibrosis metabolism, Oral Submucous Fibrosis pathology, Ki-67 Antigen metabolism, Tumor Suppressor Protein p53 metabolism, Biomarkers, Tumor metabolism, Mouth Neoplasms pathology, Mouth Neoplasms metabolism, Cell Transformation, Neoplastic metabolism, Cell Transformation, Neoplastic pathology
Abstract

Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder (PMD) characterized by a high rate of malignant transformation (MT). OSMF exhibits atrophic epithelium yet has a high proliferation rate. Both p53 and Ki67 are nuclear proteins associated with cell proliferation, detectable in the early stages of oral cancer (OC). This study aimed to analyze the efficacy of p53 and Ki67 immuno-expression as tools for predicting malignant transformation in OSMF cases. The objective was to correlate the expression of p53 and Ki67 with demographic and chewing habits data., Materials and Methods: The study group consisted of 60 histopathologically diagnosed cases of OSMF, 60 cases of OC as positive controls, and 60 cases of NOM as negative controls. Immunohistochemistry was performed on neutral-buffered formalin-fixed, paraffin-embedded tissue sections of 3 μm thickness, using ready-to-use anti-human p53 protein (clone DO-7) and monoclonal antibody for Ki67 antigen (clone MIB-1). Statistical analysis was conducted using SPSS software version 21, employing the chi-square test (p < 0.05)., Results: The expression of p53 and Ki67 was significantly higher in OSMF samples compared to NOM samples, but lower than in OC samples. When the expression levels of both p53 and Ki67 were correlated with demographic and chewing habits data, the results were statistically significant., Conclusion: The overexpression of p53 and Ki67 may contribute to the progression of MT in OSM. Early detection of these biomarkers is crucial for preventing MT, which also helps reduce the morbidity and mortality of OC. Therefore, both p53 and Ki67 can serve as predictive biomarkers for the early detection of MT in high-risk OSMF patients.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results