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1. The best linear unbiased prediction (BLUP) method as a tool to estimate the lifetime risk of pancreatic ductal adenocarcinoma in high-risk individuals with no known pathogenic germline variants

Author

Cristina-Marianini-Rios, Sanchez, María E. Castillo, de Paredes, Ana García García, Rodríguez, Mercedes, Barreto, Emma, López, Jorge Villalón, Fuentes, Raquel, Beltrán, María Muñoz, Sanjuanbenito, Alfonso, Lobo, Eduardo, Caminoa, Alejandra, Ruz-Caracuel, Ignacio, Durán, Sergio López, Olcina, José Ramón Foruny, Blázquez, Javier, Sequeros, Enrique Vázquez, Carrato, Alfredo, Ávila, Jose Carlos Martínez, and Earl, Julie

Published
2024
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2. The Spanish Familial Pancreatic Cancer Registry (PANGENFAM): a decade follow-up of individuals at high-risk for pancreatic cancer

Author

Earl, Julie, Fuentes, Raquel, Sanchez, María E. Castillo, de Paredes, Ana García García, Muñoz, María, Sanjuanbenito, Alfonso, Lobo, Eduardo, Caminoa, Alejandra, Rodríguez, Mercedes, Barreto, Emma, López, Jorge Villalón, Ruz-Caracuel, Ignacio, Durán, Sergio López, Olcina, José Ramón Foruny, Sánchez, Bárbara Luna, Páez, Sonia Camaño, Torres, Ana, Blázquez, Javier, Sequeros, Enrique Vázquez, and Carrato, Alfredo

Published
2024
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4. Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)

Author

Rojas-Holguín, Adela, Fondevila-Campo, Constantino, Sanjuanbenito, Alfonso, Fabregat-Prous, Joan, Secanella-Medayo, Luís, Rotellar-Sastre, Fernando, Pardo-Sánchez, Fernando, Prieto-Calvo, Mikel, Marín-Ortega, Héctor, Sánchez-Cabús, Santiago, Diez-Valladares, Luis, Alonso-Casado, Óscar, González-Serrano, Carmen, Rodríguez-Sanjuan, Juan Carlos, García-Plaza, Gabriel, Jaén-Torrejimeno, Isabel, Suárez-Muñoz, Miguel Ángel, Becerra-Massare, Antonio, Rio, Paula Senra-del, Pando, Elizabeth, López-Andújar, Rafael, Muñoz-Forner, Elena, Rodriguez-López, Mario, Pereira, Fernando, Serrablo-Requejo, Alejandro, Turrión, Víctor Sánchez, Garrido, Manuel Jiménez, Burdío, Fernando, Martín-Pérez, Elena, Estevan-Estevan, Rafael, López-Guerra, Diego, Castell-Gómez, José, Salinas-Gómez, Javier, López-Baena, José Ángel, López-Ben, Santiago, Solar-García, Lorena, Pérez-Alonso, Alejandro J., Martínez-Insfran, Luis Alberto, Blas, Juan Luis, Cornejo, Marian, Gutierrez-Calvo, Alberto, Pozo, Carlos Domingo-del, Ochando-Cerdan, Federico, Muñoz-Bellvís, Luis, Rebollar-Saenz, José, Sánchez, Belinda, Jover, José María, Gómez-Bravo, Miguel Ángel, Ramia, José M., and Blanco-Fernández, Gerardo

Published
2024
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7. Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)

Author

Blanco-Fernández, Gerardo, Fondevila-Campo, Constantino, Sanjuanbenito, Alfonso, Fabregat-Prous, Joan, Secanella-Medayo, Luís, Rotellar-Sastre, Fernando, Pardo-Sánchez, Fernando, Prieto-Calvo, Mikel, Marín-Ortega, Héctor, Sánchez-Cabús, Santiago, Diez-Valladares, Luis, Alonso-Casado, Óscar, González-Serrano, Carmen, Rodríguez-Sanjuan, Juan Carlos, García-Plaza, Gabriel, Jaén-Torrejimeno, Isabel, Suárez-Muñoz, Miguel Ángel, Becerra-Massare, Antonio, Rio, Paula Senra-del, Pando, Elizabeth, López-Andújar, Rafael, Muñoz-Forner, Elena, Rodriguez-López, Mario, Pereira, Fernando, Serrablo-Requejo, Alejandro, Turrión, Víctor Sánchez, Garrido, Manuel Jiménez, Burdío, Fernando, Martín-Pérez, Elena, Estevan-Estevan, Rafael, López-Guerra, Diego, Castell-Gómez, José, Salinas-Gómez, Javier, López-Baena, José Ángel, López-Ben, Santiago, Solar-García, Lorena, Pérez-Alonso, Alejandro J., Martínez-Insfran, Luis Alberto, Blas, Juan Luis, Cornejo, Marian, Gutierrez-Calvo, Alberto, Pozo, Carlos Domingo-del, Ochando-Cerdan, Federico, Muñoz-Bellvís, Luis, Rebollar-Saenz, José, Sánchez, Belinda, Jover, José María, Gómez-Bravo, Miguel Ángel, Ramia, José M., and Rojas-Holguín, Adela

Published
2022
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13. Abstract A012: The Spanish Familial Pancreatic Cancer Registry (PANGENFAM): Genetic testing and follow-up of high risk individuals

Author

Melian, Emma, primary, de Paredes, Ana García García, additional, Rodríguez, Mercedes, additional, López, Jorge Villalón, additional, Muñoz, María, additional, Blaquez, Javier, additional, Ruz, Ignacio, additional, Sanjuanbenito, Alfonso, additional, Lobo, Eduardo, additional, Lopéz, Victoria, additional, Ponce, Carmen Guillen, additional, Foruny Olcina, José Ramón, additional, Durán, Sergio López, additional, Carrato, Alfredo, additional, and Earl, Julie, additional

Published
2024
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14. Multicentric Study on Total Pancreatectomies

Author

Fabregat Prous, Joan, Secanella, Lluis, Larrea, Javier, Olea, Sanchez Bueno, Francisco, Botello Martinez, Francisco, Briceño, Javier, Miyar-de León, Alberto, Serradilla, Mario, Serrablo, Alejandro, Ferrer Fabrega, Joana, Sanchez Cabús, S., Angel Gómez Bravo, Miguel, Padillo, Javier, Blanco, Laia, Balcells, J., Cugat, Esteban, García Domingo, Maribel, Muñoz Bellvis, Luis, Dolores Perez Diaz, Maria, Santoyo Santoyo, Julio, Sanchez, Belinda, Villegas, Trinidad, Pacho, Silvino, Díez Valladares, Luis, Rebollar, Jose, Ángel Suárez Muñoz, Miguel, Domínguez, Elías, Martín Perez, Elena, Falgueras, Laia, Poves, Ignasi, Artigas, Vicenç, Sabater, Luis, Garcia Gil, Agustin, Ignacio Miota de Llama, Jose, Manzanet, Gerardo, Carlos Pino, Jose, Carlos Rodríguez Sanjuán, Juan, Lluis, F., Ausania, Fabio, Alkorta Zuloaga, Maialen, Escartín, Jorge, Salas, Manel, Domingo, Carlos, Artigues Sánchez de Rojas, Enrique, Antonio Barreras Mateos, José, María Fernández Cebrián, José, Pérez Cabrera, Beatriz, Padilla Valverde, D., Sanjuanbenito, Alfonso, Iturburu Belmonte, Ignacio, Bejarano, Natalia, García Borobia, F., Toral Guinea, Pablo, Lopez Marcano, Aylhin, Asencio Arana, Francisco, Varo, Evaristo, Esteban, Rafael, Blas, Juan L., Jover Navalón, José M., Fernández Martínez, Cristina, Daban Collado, Enrique, Calvo Duran, Antonio, Vicens, J.C., Romero, J., Badía, J.M., Sánchez, Raquel, de Miguel Ibáñez, Ricardo, Pardoc, Fernando, Francos von Hunefeld, Carlos, Pereira, Fernando, Garcia Molina, Francisco, Rodríguez Prieto, Ignacio, Alonso Poza, Alfredo, Gilsanz, Carlos, Miguel Martínez Albert, Jose, Angel Morcillo, Miguel, Martínez Cortijo, Sagrario, Martín Fernández, José, Baquedano, Jesús, Castell, José, Aguiló, Javier, Carlos Bernal, Juan, Ramia, Jose M., Martin-Perez, Elena, Fabregat-Prous, Joan, Larrea y Olea, Javier, Sanchez-Bueno, Francisco, Botello-Martinez, Francisco, and Moya-Herraiz, Angel

Published
2019
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15. Estudio multicéntrico nacional sobre pancreatectomías totales

Author

Fabregat Prous, Joan, Secanella, Lluis, Larrea y Olea, Javier, Sanchez Bueno, Francisco, Botello Martinez, Francisco, Briceño, Javier, Miyar-de León, Alberto, Serradilla, Mario, Serrablo, Alejandro, Ferrer Fabrega, Joana, Sanchez Cabús, S., Angel Gómez Bravo, Miguel, Padillo, Javier, Blanco, Laia, Balcells, J., Cugat, Esteban, García Domingo, Maribel, Muñoz Bellvis, Luis, Dolores Perez Diaz, Maria, Santoyo Santoyo, Julio, Sanchez, Belinda, Villegas, Trinidad, Pacho, Silvino, Díez Valladares, Luis, Rebollar, Jose, Ángel Suárez Muñoz, Miguel, Domínguez, Elías, Martín Perez, Elena, Falgueras, Laia, Poves, Ignasi, Artigas, Vicenç, Sabater, Luis, Garcia Gil, Agustin, Ignacio Miota de Llama, Jose, Manzanet, Gerardo, Carlos Pino, Jose, Carlos Rodríguez Sanjuán, Juan, Lluis, F., Ausania, Fabio, Alkorta Zuloaga, Maialen, Escartín, Jorge, Salas, Manel, Domingo, Carlos, Artigues Sánchez de Rojas, Enrique, Antonio Barreras Mateos, José, María Fernández Cebrián, José, Pérez Cabrera, Beatriz, Padilla Valverde, D., Sanjuanbenito, Alfonso, Iturburu Belmonte, Ignacio, Bejarano, Natalia, García Borobia, F., Toral Guinea, Pablo, Lopez Marcano, Aylhin, Asencio Arana, Francisco, Varo, Evaristo, Esteban, Rafael, Blas, Juan Laaa, Jover Navalón, José M., Fernández Martínez, Cristina, Daban Collado, Enrique, Calvo Duran, Antonio, Vicens, J.C., Romero, J., Badía, J.M., Sánchez, Raquel, de Miguel Ibáñez, Ricardo, Pardoc, Fernando, Francos von Hunefeld, Carlos, Pereira, Fernando, Garcia Molina, Francisco, Rodríguez Prieto, Ignacio, Alonso Poza, Alfredo, Gilsanz, Carlos, Miguel Martínez Albert, Jose, Angel Morcillo, Miguel, Martínez Cortijo, Sagrario, Martín Fernández, José, Baquedano, Jesús, Castell, José, Aguiló, Javier, Carlos Bernal, Juan, Ramia, Jose M., Martin-Perez, Elena, Fabregat-Prous, Joan, Sanchez-Bueno, Francisco, Botello-Martinez, Francisco, and Moya-Herraiz, Angel

Published
2019
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16. Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Author

Díaz-Alejo, Jesús Frutos, primary, April-Monn, Simon, additional, Cihova, Marina, additional, Buocikova, Verona, additional, Villalón López, Jorge, additional, Urbanova, Maria, additional, Lechuga, Carmen G., additional, Tomas, Miroslav, additional, Dubovan, Peter, additional, Sánchez, Bárbara Luna, additional, Páez, Sonia Camaño, additional, Sanjuanbenito, Alfonso, additional, Lobo, Eduardo, additional, Romio de la Heras, Estefanía, additional, Guerra, Carmen, additional, de la Pinta, Carolina, additional, Barreto Melian, Emma, additional, Rodríguez Garrote, Mercedes, additional, Carrato, Alfredo, additional, Ruiz-Cañas, Laura, additional, Sainz,, Bruno, additional, Torres, Ana, additional, Smolkova, Bozena, additional, and Earl, Julie, additional

Published
2023
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17. The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells

Author

López-Gil, Juan Carlos, García-Silva, Susana, Ruiz-Cañas, Laura, Navarro, Diego, Palencia-Campos, Adrián, Giráldez-Trujillo, Antonio, Earl, Julie, Dorado, Jorge, Gómez-López, Gonzalo, Monfort-Vengut, Ana, Alcalá, Sonia, Gaida, Matthias M, García-Mulero, Sandra, Cabezas-Sáinz, Pablo, Batres-Ramos, Sandra, Barreto, Emma, Sánchez-Tomero, Patricia, Vallespinós, Mireia, Ambler, Leah, Lin, Meng-Lay, Aicher, Alexandra, García García de Paredes, Ana, de la Pinta, Carolina, Sanjuanbenito, Alfonso, Ruz-Caracuel, Ignacio, Rodríguez-Garrote, Mercedes, Guerra, Carmen, Carrato, Alfredo, de Cárcer, Guillermo, Sánchez, Laura, Nombela-Arrieta, César, Espinet, Elisa, Sanchez-Arevalo Lobo, Víctor Javier, Heeschen, Christopher, and Sainz, Bruno

Abstract

ObjectivePancreatic ductal adenocarcinoma (PDAC) has limited therapeutic options, particularly with immune checkpoint inhibitors. Highly chemoresistant ‘stem-like’ cells, known as cancer stem cells (CSCs), are implicated in PDAC aggressiveness. Thus, comprehending how this subset of cells evades the immune system is crucial for advancing novel therapies.DesignWe used the KPC mouse model (LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre) and primary tumour cell lines to investigate putative CSC populations. Transcriptomic analyses were conducted to pinpoint new genes involved in immune evasion. Overexpressing and knockout cell lines were established with lentiviral vectors. Subsequent in vitrococulture assays, in vivomouse and zebrafish tumorigenesis studies, and in silicodatabase approaches were performed.ResultsUsing the KPC mouse model, we functionally confirmed a population of cells marked by EpCAM, Sca-1 and CD133 as authentic CSCs and investigated their transcriptional profile. Immune evasion signatures/genes, notably the gene peptidoglycan recognition protein 1 (PGLYRP1), were significantly overexpressed in these CSCs. Modulating PGLYRP1 impacted CSC immune evasion, affecting their resistance to macrophage-mediated and T-cell-mediated killing and their tumourigenesis in immunocompetent mice. Mechanistically, tumour necrosis factor alpha (TNFα)-regulated PGLYRP1 expression interferes with the immune tumour microenvironment (TME) landscape, promoting myeloid cell-derived immunosuppression and activated T-cell death. Importantly, these findings were not only replicated in human models, but clinically, secreted PGLYRP1 levels were significantly elevated in patients with PDAC.ConclusionsThis study establishes PGLYRP1 as a novel CSC-associated marker crucial for immune evasion, particularly against macrophage phagocytosis and T-cell killing, presenting it as a promising target for PDAC immunotherapy.

Published
2024
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18. Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)

Author

Universidad de Sevilla. Departamento de Cirugía, Blanco Fernández, Gerardo, Fondevila Campo, Constantino, Sanjuanbenito, Alfonso, Rodríguez López, Mario, Pérez Alonso, Alejandro J., Gómez Bravo, Miguel Ángel, Rojas Holguín, Adela, Universidad de Sevilla. Departamento de Cirugía, Blanco Fernández, Gerardo, Fondevila Campo, Constantino, Sanjuanbenito, Alfonso, Rodríguez López, Mario, Pérez Alonso, Alejandro J., Gómez Bravo, Miguel Ángel, and Rojas Holguín, Adela

Abstract

Background: Renal Cell Carcinoma (RCC) occasionally spreads to the pancreas. The purpose of our study is to evaluate the short and long-term results of a multicenter series in order to determine the effect of surgical treatment on the prognosis of these patients. Methods: Multicenter retrospective study of patients undergoing surgery for RCC pancreatic metastases, from January 2010 to May 2020. Variables related to the primary tumor, demographics, clinical char- acteristics of metastasis, location in the pancreas, type of pancreatic resection performed and data on short and long-term evolution after pancreatic resection were collected. Results: The study included 116 patients. The mean time between nephrectomy and pancreatic metas- tases’ resection was 87.35 months (ICR: 1.51e332.55). Distal pancreatectomy was the most performed technique employed (50 %). Postoperative morbidity was observed in 60.9 % of cases (Clavien-Dindo greater than IIIa in 14 %). The median follow-up time was 43 months (13e78). Overall survival (OS) rates at 1, 3, and 5 years were 96 %, 88 %, and 83 %, respectively. The disease-free survival (DFS) rate at 1, 3, and 5 years was 73 %, 49 %, and 35 %, respectively. Significant prognostic factors of relapse were a disease free interval of less than 10 years (2.05 [1.13e3.72], p 0.02) and a history of previous extrapancreatic metastasis (2.44 [1.22e4.86], p 0.01). Conclusions: Pancreatic resection if metastatic RCC is found in the pancreas is warranted to achieve higher overall survival and disease-free survival, even if extrapancreatic metastases were previously removed. The existence of intrapancreatic multifocal compromise does not always warrant the perfor- mance of a total pancreatectomy in order to improve survival.

Published
2022

20. Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)

Author

Blanco Fernández, Gerardo, Fondevila Campo, Constantino, Sanjuanbenito, Alfonso, Rodríguez López, Mario, Pérez Alonso, Alejandro J., Gómez Bravo, Miguel Ángel, Rojas Holguín, Adela, and Universidad de Sevilla. Departamento de Cirugía

Subjects
Pancreatectomy, Recurrence, Metastases, Renal cell carcinoma
Abstract

Background: Renal Cell Carcinoma (RCC) occasionally spreads to the pancreas. The purpose of our study is to evaluate the short and long-term results of a multicenter series in order to determine the effect of surgical treatment on the prognosis of these patients. Methods: Multicenter retrospective study of patients undergoing surgery for RCC pancreatic metastases, from January 2010 to May 2020. Variables related to the primary tumor, demographics, clinical char- acteristics of metastasis, location in the pancreas, type of pancreatic resection performed and data on short and long-term evolution after pancreatic resection were collected. Results: The study included 116 patients. The mean time between nephrectomy and pancreatic metas- tases’ resection was 87.35 months (ICR: 1.51e332.55). Distal pancreatectomy was the most performed technique employed (50 %). Postoperative morbidity was observed in 60.9 % of cases (Clavien-Dindo greater than IIIa in 14 %). The median follow-up time was 43 months (13e78). Overall survival (OS) rates at 1, 3, and 5 years were 96 %, 88 %, and 83 %, respectively. The disease-free survival (DFS) rate at 1, 3, and 5 years was 73 %, 49 %, and 35 %, respectively. Significant prognostic factors of relapse were a disease free interval of less than 10 years (2.05 [1.13e3.72], p 0.02) and a history of previous extrapancreatic metastasis (2.44 [1.22e4.86], p 0.01). Conclusions: Pancreatic resection if metastatic RCC is found in the pancreas is warranted to achieve higher overall survival and disease-free survival, even if extrapancreatic metastases were previously removed. The existence of intrapancreatic multifocal compromise does not always warrant the perfor- mance of a total pancreatectomy in order to improve survival.

Published
2022

26. Preoperative clinical model to predict myocardial injury after non-cardiac surgery: a retrospective analysis from the MANAGE cohort in a Spanish hospital

Author

Serrano, Ana Belen, primary, Gomez-Rojo, Maria, additional, Ureta, Eva, additional, Nuñez, Monica, additional, Fernández Félix, Borja, additional, Velasco, Elisa, additional, Burgos, Javier, additional, Popova, Ekaterine, additional, Urrutia, Gerard, additional, Gomez, Victoria, additional, del Rey, Jose Manuel, additional, Sanjuanbenito, Alfonso, additional, Zamora, Javier, additional, Monteagudo, Juan Manuel, additional, Pestaña, David, additional, de la Torre, Basilio, additional, and Candela-Toha, Ángel, additional

Published
2021
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32. Resultados de una encuesta sobre el soporte nutricional perioperatorio en la cirugía pancreática y biliar en España

Author

Loinaz, Carmelo, Ochando, Federico, Vicente, Emilio, Serrablo, Alejandro, López Cillero, Pablo, Gómez, Miguel Ángel, Fabregat Prous, Joan, Varo, Evaristo, Miyar de Leon, Albert, Fondevila, Constantino, Valdivieso, Andrés, Blanco, Gerardo, Sánchez, Belinda, López Andújar, Rafael, Fundora, Yilian, Cugat Andorrà, Esteban, Díez Valladares, Luis, Herrera, Javier, García Gil, Agustín, Morales, Rafael, Pardo, Fernando, Sabater, Luis, Baena, José Ángel, Muñoz Bellvis, Luis, Martín Pérez, Elena, Pérez Saborido, Baltasar, Suárez, Miguel Ángel, Meneu, Juan Carlos, Albiol, Maite, Sanjuanbenito, Alfonso, Ramia, José Miguel, Pereira, Fernando, Paseiro, Gloria, Palomo, Juan Carlos, Leon, Miguel, GENPOCIRP (Grupo Encuesta Nutrición PeriOperatoria en CIRugia Pancreatobiliar), UAM. Departamento de Cirugía, and Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)

Subjects
medicine.medical_specialty, Medicina, Medicine (miscellaneous), Páncreas. Biliar. Cirugía. Nutrición, Nutritional Status, Critical Care and Intensive Care Medicine, Pancreatic head, Biliary surgery, Pancreatic surgery, Pancreatectomy, Surveys and Questionnaires, medicine, Humans, Malalties del pàncrees, Pancreas, Nutrició, Nutrition, Nutrition and Dietetics, Nutritional Support, business.industry, General surgery, Biliary, Guideline, Perioperative, Middle Aged, Biliar, Pancréas diseases, Biliary Tract Surgical Procedures, Páncreas, Solid food, Spain, Nutrición, Surgery, Preoperative fasting, business, Oral feeding
Abstract

Introduction: a survey on peri-operative nutritional support in pancreatic and biliary surgery among Spanish hospitals in 2007 showed that few surgical groups followed the 2006 ESPEN guidelines. Ten years later we sent a questionnaire to check the current situation. Methods: a questionnaire with 21 items sent to 38 centers, related to fasting time before and after surgery, nutritional screening use and type, time and type of peri-operative nutritional support, and number of procedures. Results: thirty-four institutions responded. The median number of pancreatic resections (head/total) was 29.5 (95% CI: 23.0-35; range, 5-68) (total, 1002); of surgeries for biliary malignancies (non-pancreatic), 9.8 (95% CI: 7.3-12.4; range, 2-30); and of main biliary resections for benign conditions, 10.4 (95% CI: 7.6-13.3; range, 2-33). Before surgery, only 41.2% of the sites used nutritional support (< 50% used any nutritional screening procedure). The mean duration of preoperative fasting for solid foods was 9.3 h (range, 6-24 h); it was 6.6 h for liquids (range, 2-12). Following pancreatic surgery, 29.4% tried to use early oral feeding, but 88.2% of the surveyed teams used some nutritional support; 26.5% of respondents used TPN in 100% of cases. Different percentages of TPN and EN were used in the other centers. In malignant biliary surgery, 22.6% used TPN always, and EN in 19.3% of cases. Conclusions: TPN is the commonest nutrition approach after pancreatic head surgery. Only 29.4% of the units used early oral feeding, and 32.3% used EN; 22.6% used TPN regularly after surgery for malignant biliary tumours. The 2006 ESPEN guideline recommendations are not regularly followed 12 years after their publication in our country., Introducción: realizamos una encuesta sobre soporte nutricional perioperatorio en cirugía pancreática y biliar en hospitales españoles en 2007, que mostró que pocos grupos quirúrgicos seguían las guías de ESPEN 2006. Diez años después enviamos un cuestionario para comprobar la situación actual. Métodos: treinta y ocho centros recibieron un cuestionario con 21 preguntas sobre tiempo de ayunas antes y después de la cirugía, cribado nutricional, duración y tipo de soporte nutricional perioperatorio, y número de procedimientos. Resultados: respondieron 34 grupos. La mediana de pancreatectomías (cabeza/total) fue de 29,5 (IC 95 %: 23,0-35; rango, 5-68) (total, 1002), la de cirugías biliares malignas de 9,8 (IC 95 %: 7,3-12,4; rango, 2-30) y la de resecciones biliares por patología benigna de 10,4 (IC 95 %: 7,6-13,3; rango, 2-33). Solo el 41,2 % de los grupos utilizaban soporte nutricional antes de la cirugía (< 50 % habian efectuado un cribado nutricional). El tiempo medio de ayuno preoperatorio para sólidos fue de 9,3 h (rango, 6-24 h), y de 6,6 h para líquidos (rango, 2-12). Tras la pancreatectomía, el 29,4 % habían intentado administrar una dieta oral precoz, pero el 88,2 % de los grupos usaron algún tipo de soporte nutricional y el 26,5 % usaron NP en el 100 % de los casos. Los demás grupos usaron diferentes porcentajes de NP y NE en sus casos. En la cirugía biliar maligna, el 22,6 % utilizaron NP siempre y NE en el 19,3 % de los casos. Conclusiones: la NP es el soporte nutricional más utilizado tras la cirugía de cabeza pancreática. Solo el 29,4 % de las unidades usan nutrición oral precoz y el 32,3 % emplean la NE tras este tipo de cirugía. El 22,6 % de las instituciones usan NP habitualmente tras la cirugía de tumores biliares malignos. Las guías ESPEN 2006 no se siguen de forma habitual en nuestro país tras más de 10 años desde su publicación.

Published
2020

33. Lumen-apposing metal stents versus biliary fully-covered metal stents for EUS-guided drainage of pancreatic fluid collections: a case control study

Author

Garcia Garcia de Paredes, Ana, additional, Gonzalez Martin, Juan Angel, additional, Foruny Olcina, Jose Ramon, additional, Juzgado Lucas, Diego, additional, Gonzalez Panizo, Fernando, additional, Lopez Duran, Sergio, additional, Martinez Sanchez, Alba, additional, Sanjuanbenito, Alfonso, additional, Caminoa, Alejandra, additional, Albillos, Agustin, additional, and Vazquez-Sequeiros, Enrique, additional

Published
2020
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39. Estudio multicéntrico nacional sobre pancreatectomías totales

Author

Ramia, Jose M., primary, Martin-Perez, Elena, additional, Poves, Ignasi, additional, Fabregat-Prous, Joan, additional, Larrea y Olea, Javier, additional, Sanchez-Bueno, Francisco, additional, Botello-Martinez, Francisco, additional, Briceño, Javier, additional, Miyar-de León, Alberto, additional, Serradilla, Mario, additional, Moya-Herraiz, Angel, additional, Fabregat Prous, Joan, additional, Secanella, Lluis, additional, Sanchez Bueno, Francisco, additional, Botello Martinez, Francisco, additional, Serrablo, Alejandro, additional, Ferrer Fabrega, Joana, additional, Sanchez Cabús, S., additional, Angel Gómez Bravo, Miguel, additional, Padillo, Javier, additional, Blanco, Laia, additional, Balcells, J., additional, Cugat, Esteban, additional, García Domingo, Maribel, additional, Muñoz Bellvis, Luis, additional, Dolores Perez Diaz, Maria, additional, Santoyo Santoyo, Julio, additional, Sanchez, Belinda, additional, Villegas, Trinidad, additional, Pacho, Silvino, additional, Díez Valladares, Luis, additional, Rebollar, Jose, additional, Ángel Suárez Muñoz, Miguel, additional, Domínguez, Elías, additional, Martín Perez, Elena, additional, Falgueras, Laia, additional, Artigas, Vicenç, additional, Sabater, Luis, additional, Garcia Gil, Agustin, additional, Ignacio Miota de Llama, Jose, additional, Manzanet, Gerardo, additional, Carlos Pino, Jose, additional, Carlos Rodríguez Sanjuán, Juan, additional, Lluis, F., additional, Ausania, Fabio, additional, Alkorta Zuloaga, Maialen, additional, Escartín, Jorge, additional, Salas, Manel, additional, Domingo, Carlos, additional, Artigues Sánchez de Rojas, Enrique, additional, Antonio Barreras Mateos, José, additional, María Fernández Cebrián, José, additional, Pérez Cabrera, Beatriz, additional, Padilla Valverde, D., additional, Sanjuanbenito, Alfonso, additional, Iturburu Belmonte, Ignacio, additional, Bejarano, Natalia, additional, García Borobia, F., additional, Toral Guinea, Pablo, additional, Lopez Marcano, Aylhin, additional, Asencio Arana, Francisco, additional, Varo, Evaristo, additional, Esteban, Rafael, additional, Blas, Juan Laaa, additional, Jover Navalón, José M., additional, Fernández Martínez, Cristina, additional, Daban Collado, Enrique, additional, Calvo Duran, Antonio, additional, Vicens, J.C., additional, Romero, J., additional, Badía, J.M., additional, Sánchez, Raquel, additional, de Miguel Ibáñez, Ricardo, additional, Pardoc, Fernando, additional, Francos von Hunefeld, Carlos, additional, Pereira, Fernando, additional, Garcia Molina, Francisco, additional, Rodríguez Prieto, Ignacio, additional, Alonso Poza, Alfredo, additional, Gilsanz, Carlos, additional, Miguel Martínez Albert, Jose, additional, Angel Morcillo, Miguel, additional, Martínez Cortijo, Sagrario, additional, Martín Fernández, José, additional, Baquedano, Jesús, additional, Castell, José, additional, Aguiló, Javier, additional, and Carlos Bernal, Juan, additional

Published
2019
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40. UTILIDAD DE LAS PRÓTESIS DE APOSICIÓN LUMINAL (PAL) HOT AXIOS COMO TRATAMIENTO DEFINITIVO DE LA PATOLOGÍA VESICULAR NO QUIRÚRGICA

Author

López-Durán, Sergio, primary, Vázquez-Sequeiros, Enrique, additional, Foruny, José Ramón, additional, González Martín, Juan Ángel, additional, Ríos, Raquel, additional, Defarges, Víctor, additional, García García de Paredes, Ana, additional, Sanjuanbenito, Alfonso, additional, Juzgado, Diego, additional, and Albillos, Agustín, additional

Published
2018
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44. Additional file 6: Figure S4. of Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

Author

Earl, Julie, Garcia-Nieto, Sandra, Martinez-Avila, Jose, Montans, José, Sanjuanbenito, Alfonso, Rodríguez-Garrote, Mercedes, Lisa, Eduardo, Mendía, Elena, Lobo, Eduardo, Malats, Núria, Carrato, Alfredo, and Guillen-Ponce, Carmen

Abstract

Graphical test of the Weibull assumption. Plot of log(-log(Survival)) vs log(time). When the result is a straight line, survival time is considered to follow a Weibull distribution. (PDF 31 kb)

Published
2015
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45. Additional file 1: Table S1. of Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

Author

Earl, Julie, Garcia-Nieto, Sandra, Martinez-Avila, Jose, Montans, José, Sanjuanbenito, Alfonso, Rodríguez-Garrote, Mercedes, Lisa, Eduardo, Mendía, Elena, Lobo, Eduardo, Malats, Núria, Carrato, Alfredo, and Guillen-Ponce, Carmen

Abstract

Analysis of clinical parameters in the patient cohorts. (DOC 34 kb)

Published
2015
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46. Additional file 4: Table S2. of Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

Author

Earl, Julie, Garcia-Nieto, Sandra, Martinez-Avila, Jose, Montans, José, Sanjuanbenito, Alfonso, Rodríguez-Garrote, Mercedes, Lisa, Eduardo, Mendía, Elena, Lobo, Eduardo, Malats, Núria, Carrato, Alfredo, and Guillen-Ponce, Carmen

Subjects
neoplasms, digestive system diseases
Abstract

Statistical analysis of overall survival with regard to the detection of CTC and mutant KRAS cfDNA in plasma. N.B: The Cox and Weibull regression are corrected by age and sex. (DOC 30 kb)

Published
2015
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47. Additional file 3: Figure S2. of Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

Author

Earl, Julie, Garcia-Nieto, Sandra, Martinez-Avila, Jose, Montans, José, Sanjuanbenito, Alfonso, Rodríguez-Garrote, Mercedes, Lisa, Eduardo, Mendía, Elena, Lobo, Eduardo, Malats, Núria, Carrato, Alfredo, and Guillen-Ponce, Carmen

Subjects
endocrine system diseases, neoplasms, digestive system diseases, respiratory tract diseases
Abstract

KRAS G12D mutation detection in spike in plasma samples. (a) G12D mutant DNA detection by ddPCR and (b) correlation of copies of G12D KRAS mutant DNA and spike in concentration. (PDF 45 kb)

Published
2015
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48. Additional file 2: Figure S1. of Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

Author

Earl, Julie, Garcia-Nieto, Sandra, Martinez-Avila, Jose, Montans, José, Sanjuanbenito, Alfonso, Rodríguez-Garrote, Mercedes, Lisa, Eduardo, Mendía, Elena, Lobo, Eduardo, Malats, Núria, Carrato, Alfredo, and Guillen-Ponce, Carmen

Subjects
endocrine system diseases, fungi, neoplasms, digestive system diseases, respiratory tract diseases
Abstract

Specificity of KRAS mutation assays (G12D, G12R and G12V) determined by ddPCR of KRAS mutant and WT DNA. (PDF 99 kb)

Published
2015
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49. Additional file 5: Figure S3. of Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

Author

Earl, Julie, Garcia-Nieto, Sandra, Martinez-Avila, Jose, Montans, José, Sanjuanbenito, Alfonso, Rodríguez-Garrote, Mercedes, Lisa, Eduardo, Mendía, Elena, Lobo, Eduardo, Malats, Núria, Carrato, Alfredo, and Guillen-Ponce, Carmen

Subjects
fungi, neoplasms, digestive system diseases
Abstract

Estimated Survival Curves adjusted by sex and age using Cox regression for CTC and KRAS Mutant models. (PDF 23 kb)

Published
2015
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