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Abstract This paper demonstrates the novel approach of sub-micron-thick InGaAs broadband photodetectors (PDs) designed for high-resolution imaging from the visible to short-wavelength infrared (SWIR) spectrum. Conventional approaches encounter challenges such as low resolution and crosstalk issues caused by a thick absorption layer (AL). Therefore, we propose a guided-mode resonance (GMR) structure to enhance the quantum efficiency (QE) of the InGaAs PDs in the SWIR region with only sub-micron-thick AL. The TiOx/Au-based GMR structure compensates for the reduced AL thickness, achieving a remarkably high QE (>70%) from 400 to 1700 nm with only a 0.98 μm AL InGaAs PD (defined as 1 μm AL PD). This represents a reduction in thickness by at least 2.5 times compared to previous results while maintaining a high QE. Furthermore, the rapid transit time is highly expected to result in decreased electrical crosstalk. The effectiveness of the GMR structure is evident in its ability to sustain QE even with a reduced AL thickness, simultaneously enhancing the transit time. This breakthrough offers a viable solution for high-resolution and low-noise broadband image sensors.

Abstract Low-level somatic mutations in the human brain are implicated in various neurological disorders. The contribution of low-level brain somatic mutations to autism spectrum disorder (ASD), however, remains poorly understood. Here, we performed high-depth exome sequencing with an average read depth of 559.3x in 181 cortical, cerebellar, and peripheral tissue samples to identify brain somatic single nucleotide variants (SNVs) in 24 ASD subjects and 31 controls. We detected ~2.4 brain somatic SNVs per exome per single brain region, with a variant allele frequency (VAF) as low as 0.3%. The mutational profiles, including the number, signature, and type, were not significantly different between the ASD patients and controls. Intriguingly, when considering genes with low-level brain somatic SNVs and ASD risk genes with damaging germline SNVs together, the merged set of genes carrying either somatic or germline SNVs in ASD patients was significantly involved in ASD-associated pathophysiology, including dendrite spine morphogenesis (p = 0.025), mental retardation (p = 0.012), and intrauterine growth retardation (p = 0.012). Additionally, the merged gene set showed ASD-associated spatiotemporal expression in the early and mid-fetal cortex, striatum, and thalamus (all p

Due to the production of huge quantity of potentially toxic and recalcitrant pollutants, which cannot be completely decomposed with conventional biological wastewater treatment processes, in the paper industry, reliable treatment processes are highly required. This study conducted effective experiments of different series of processes to decompose persistent contaminants in the paper wastewater under controlled conditions of the used processes to meet the effluent quality standards of Korea Ministry of Environment in terms of CODMn (< 130 mg/L). For Biological treatment, Fenton, and photo-Fenton processes, various operational parameters were adjusted to determine the optimal conditions for CODMn value. Due to large quantity of refractory contaminants in the wastewater, single treatment process was not enough to meet the requirement of CODMn. Herein, we achieved the goal with two approaches: (1) secondary Fenton oxidation after biological and primary Fenton treatments, and (2) photo-Fenton treatment after biological treatment alone. The secondary Fenton oxidation process is an additional process operated under the same condition of the primary Fenton treatment to treat the effluent from the primary Fenton treatment. Ultimately, the residual CODMn concentrations of the secondary Fenton and single photo-Fenton treatment were 62.7 and 85.3 mg/L, respectively. However, the secondary Fenton required larger amounts of reagents and produced significant amounts of sludge, which require post-treatment, compared to single photo-Fenton treatment. Therefore, it suggests that the application of photo-Fenton was more efficient than the secondary Fenton in terms of economic feasibility and post-treatment requirement.

Virtual reality (VR) has recently been adopted for driving simulations to enhance their realism and thus improve the validity of the simulation results. However, given that perceived realism is a subjective factor that varies by individual, understanding and predicting perceived realism in VR driving simulations are prerequisites for enhancing their validity. Studies on VR have investigated how individual factors such as psychophysiological metrics are associated with perceived realism. However, how these psychophysiological metrics are associated with perceived realism in VR driving simulations has not yet been investigated. To address this problem, this study investigated the relationship between perceived realism and psychophysiological metrics, including individual characteristics (sex, age), personality traits (psychopathy, Machiavellianism, sensation seeking, impulsivity), heart rate changes during the event, and risky decision-making during the event, across three driving simulations. The results indicated that psychopathy, Machiavellianism, heart rate changes during the event, and risky decision-making during the event were significantly correlated with the perceived realism of VR driving simulations. In addition, we tested three types of machine learning models to find the appropriate ones for predicting perceived realism, showing that the tree-based algorithm had the highest prediction accuracy.

In Level-3 autonomous driving, drivers are required to take over in an emergency upon receiving a request from an autonomous vehicle (AV). However, before the deadline for the takeover request expires, drivers are not considered fully responsible for the accident, which may make them hesitant to assume control and take on full liability before the time runs out. Therefore, to prevent problems caused by late takeover, it is important to know which factors influence a driver's willingness to take over in an emergency. To address this issue, we recruited 250 participants each for both video-based and text-based surveys to investigate the takeover decision in a dilemmatic situation that can endanger the driver, with the AV either sacrificing a group of pedestrians or the driver if the participants do not intervene. The results showed that 88.2% of respondents chose to take over when the AV intended to sacrifice the driver, while only 59.4% wanted to take over when the pedestrians would be sacrificed. Additionally, when the AV's chosen path matched the participant's intention, 77.4% chose to take over when the car intended to sacrifice the driver compared with only 34.3% when the pedestrians would be sacrificed. Furthermore, other factors such as sex, driving experience, and driving preferences partially influenced takeover decisions; however, they had a smaller effect than the situational context. Overall, our findings show that regardless of the driving intention of an AV, informing drivers that their safety is at risk can enhance their willingness to take over control of an AV in critical situations.

Abstract Background Distal embolic protection devices have been widely used to reduce the incidence of embolic events during carotid artery stenting. Entrapment of an embolic protection device is an extremely rare complication, and most cases are resolved by surgical removal. Case presentation A 67-year-old male underwent carotid artery stenting with an embolic protection device. During the procedure, the embolic protection filter became entrapped within the stent. The complication was resolved endovascularly without sequelae. Conclusion The most important step in stenting is to be careful until the procedure is completed. However, if complications occur during the operation, in-depth knowledge of the catheters, wires, and devices will help the operator resolve the problem using endovascular techniques.

Iatrogenic injury of the vertebral artery during cervical spine surgery though uncommon is critical. With advances in interventional endovascular techniques, the therapeutic approach for vertebral artery injuries has changed. Nonetheless, an established strategy for their management is lacking. We report a case of pseudoaneurysm due to vertebral artery injury, during cervical spine surgery for a tumor, that was treated successfully with endovascular coiling in a plug-and-patch fashion after triple stenting failed.

Abstract Bipolar disorder (BPD) is a severe mental illness characterized by episodes of depression and mania. To investigate the molecular mechanisms underlying the pathophysiology of bipolar disorder, we performed transcriptome studies using RNA-seq data from the prefrontal cortex (PFC) of individuals with BPD and matched controls, as well as data from cell culture and animal model studies. We found 879 differentially expressed genes that were also replicated in an independent cohort of post-mortem samples. Genes involving the mechanistic target of rapamycine (mTOR) pathway were down-regulated, while genes interrelated with the mTOR pathway such as Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway were up-regulated. Gene co-expression network analyses identified a module related to the mTOR pathway that was up-regulated in BPD and also enriched for markers of endothelial cells. We also found a down-regulated co-expression module enriched for genes involved in mTOR signalling and in mTOR related pathways and enriched with neuronal markers. The mTOR related modules were also replicated in the independent cohort of samples. To investigate whether the expression of the modules related to mTOR signalling pathway could be differentially regulated in different cell types we performed comparative network analyses in experimental models. We found both up-regulated modules in the PFC significantly overlapped with an up-regulated module in the brain endothelial cells from mice treated with lipopolysaccharides (LPS) and mTOR related pathways such as JAK-STAT, PI3K-Akt and ribosome were enriched in the common genes. In addition, the down-regulated module in the PFC significantly overlapped with a down-regulated module from neurons treated with the mTOR inhibitor, Torin1 and mTOR signalling, autophagy, and synaptic vesicle cycles were significantly enriched in the common genes. These results suggest that co-expression networks related to mTOR signalling pathways may be up- or down-regulated in different cell types in the PFC of BPD. These results provide novel insights into the molecular mechanisms underlying the pathophysiology of BPD.

Abstract The passivation effects of sulfur treatment and Al2O3 passivation for AlGaInP/GaInP red micro-light-emitting-diodes (LEDs) were investigated in terms of the external quantum efficiency (EQE) and the current density showing the peak EQE (J EQE, peak). We systematically compared the electrical and optical characteristics of the micro-LEDs with and without passivation according to various sizes. Interestingly, our investigation indicated that simple electrical characteristics such as current density–voltage property are difficult to precisely reflect the minor change in electrical properties due to passivation when the device has the inherently low leakage current. Whereas the EQE was enhanced by 20% and J EQE, peak was largely shifted to a lower current density region at the LED with a size of 15 × 15 μm2. To examine the passivation effects, we carefully analyzed the EQE and J EQE, peak with the ABC recombination model, and established the methodology to investigate the influence of a sidewall in micro-LEDs. As a result, we extracted the surface recombination velocity regarding the surface passivation, showing a nearly 14% reduction with the passivation.

Fibrous hamartoma of infancy in the middle ear is extremely rare. We report the case of a 26-month-old male patient who presented with a mass in the left middle ear. A temporal bone CT scan showed complete opacification of the left middle ear and mastoid air cells without ossicular erosion. On MRI, the mass revealed heterogeneous signal intensities indicative of fat and fibrous components. A definitive diagnosis was made postoperatively based on the histological results. Although rare, fibrous hamartoma of infancy should be considered as a differential diagnosis of a middle ear mass during childhood.

We first demonstrated a slot waveguide based on a Ge-on-Si (GOS) platform with a 3 μm thickness of the Ge in the mid-infrared wavelength range at 4.2 μm. We numerically designed the slot waveguide to have a large field confinement in the slot for sensing application. Based on the design, we fabricated the GOS slot waveguide with a slot gap of 200 nm, which is coupled with in-out grating couplers. We characterized the propagation loss of the waveguides by the cut-back method and carefully compared it with channel waveguides. In fundamental TE mode, the propagation loss in the channel waveguide and the slot waveguide were quite similar (5.20 and 4.86 dB/cm, respectively), whereas the field confinement was much higher in the slot waveguides. Additionally, we simulated and analyzed the loss of the devices in terms of radiation, sidewall roughness scattering, material absorption by free-carrier absorption (FCA), and CO2. These results strongly suggest that the fabricated slot waveguide based on the GOS platform would be one of the promising building blocks for the optical gas sensor platform.

Meningioma is a common neoplasm of the central nervous system; however, primary extracranial meningioma of the paranasal sinus, especially the maxillary sinus, is rare. We report a case of primary extracranial meningioma (fibrous type) of the maxillary sinus and present a literature review of the imaging features that correlate with fibrous meningioma.

Recently, microplastics (MPs) became a big name in the world since their presence in bodies of different species, environmental media, and even in bottled drinking water was frequently reported. Several studies reported MPs’ potential threat to health of humans, animals and the ecosystem. Therefore, it is of great importance to develop reliable technologies for removing MPs in the environment. Advanced oxidation processes (AOPs) are widely studied and applied for the decomposition of different refractory contaminants in the environment. Because reactive oxygen species produced in AOPs could effectively degrade many pollutants, several AOPs were applied for MPs decomposition. Homogeneous and heterogeneous AOPs, including UV photolysis, UV/H2O2, O3, UV/visible light-induced photocatalysis, heat activated PS and PMS, and plasma, could effectively decompose various types of MPs with different sizes. However, the decomposition mostly occurred on the surface of MPs even though several studies reported complete removal of MPs. Interestingly, several studies demonstrated that treated MPs could become pollutant carriers for animals and human beings by adsorbing contaminants in the environment. However, a limited number of studies on MPs removal by AOPs are available and only few types of AOPs are recently studied even though current studies demonstrated the potential of AOPs for complete MPs removal. Therefore, more effort must be put into investigating different AOPs for complete removal of MPs in the environment. AOPs will play a key role for MPs removal in the environment in the near future, definitely.

Abstract The honey bee acetylcholinesterase 1 (AmAChE1) has been suggested to be related to stress response as judged from its elevated expression level under brood rearing-suppressed conditions. To further investigate the involvement of AmAChE1 expression in the stress response and its physiological functions, we analyzed altered expression profiles of AmAChE1 induced by diverse stress factors. In addition, transcription profiles of several heat shock protein (Hsp) genes (hsps) and the vitellogenin (Vg) gene (vg) known as general stress markers were investigated as positive references. Among the tested stress conditions, AmAChE1 expression was induced under the brood rearing-suppressed, crowding and heat shock conditions. The hsps, particularly hsp70 and hsp90, responded to seven of nine stress conditions tested, confirming that hsp expression profiles can serve as a general stress marker. Taken together, AmAChE1 expression is not suitable for using as a stress marker due to its limited response. Nevertheless, AmAChE1 expression appears to be connected, at least in part, to heat shock response and other pathways. Considering that AmAChE1 likely regulates the ACh titer particularly in non-neuronal tissues, thereby modulating the signal cascades mediated by mAChR, the AmAChE1 expression profile under different conditions likely provides important information on its physiological roles in honey bees.

The role of brain somatic mutations in neurodegenerative diseases such as Alzheimer’s disease (AD) is not well understood. Here the authors carry out high-depth exome sequencing ~500× on brain tissue from patients with AD and controls, and identify mutations in a number of genes that are known to contribute to phosphorylation and aggregation of tau, including PIN1.

Self-heating has emerged as an important performance/reliability challenge for modern MOSFETs. The challenge is further acerbated for III-V transistors, especially when integrated monolithically in a 3-D platform for applications in ultrafast logic, imagers, etc. A key challenge is the difficulty of heat-dissipation through the ultra-thin channels needed to ensure electrostatic integrity of scaled transistors. In this paper, we demonstrate an innovative use of a heat-dissipating shunt of Ni-InGaAs on InGaAs(111) in the S/D extension region, as well as the use of high-conductivity Mo contact to simultaneously improve electrical and thermal stability and heat dissipation in III-V transistors, such that the peak channel temperature is reduced by as much as 25%-30%. Given the exponential temperature sensitivity of transistor reliability, heat shunts will improve transistor lifetime significantly.

Fluorescence labeling of gold-aryl nanoparticles, AuNPs-COOH, was achieved by the covalent derivatization with dansyl chloride (DNS-Cl) reagent (5-naphthalene-1-sulfonyl chloride) for potential ssDNA recognition. The fluorescent gold nanoparticles of AuNPs-C6H4-4-COO-dansyl (AuNPs-DNS) of spherical shape and a size of 19.3 ± 8.3 nm were synthesized in a carbonate-bicarbonate buffer (pH = 10.6) at 37 °C. The fluorescence emission at 475 nm was acquired using fluorescence spectroscopy and investigated using time-resolved photoluminescence. The conjugation of ssDNA to AuNPs-DNS using the freeze-thaw and salt-aging methods was confirmed by fluorescence emission quenching, gel electrophoresis separation, and lifetime decrease. Conjugated ssDNA to AuNPs-DNS using the freeze-thaw method was more efficient than the salt-aging method. The purity of ssDNA upon conjugation was measured with optical density, and the obtained A260/A280 ratio was in the range of 1.7–2.0. This research can be applied to other nucleotide recognition and theranostics.

Herein, an approach to form high‐quality GaAs‐based flexible photodetectors (PDs) is first demonstrated by metal wafer bonding (MWB) and high‐throughput epitaxial lift‐off (ELO) with encapsulated thermally grown silicon dioxide (t‐SiO2) for chronic biomedical implants. The flexible GaAs PDs demonstrate responsivity over a wide range of visible and near‐infrared wavelengths. Regarding certain diagnoses, high‐performance PDs are essential for precise treatments with long‐term optoelectronic implants, and the long‐term stability and reliable encapsulation of GaAs PDs will play a major role when optoelectronics are injected into biofluids. t‐SiO2, as an encapsulation barrier, is stable without increasing the leakage current for over 120 h in phosphate‐buffered saline (PBS) at 70 °C. By Arrhenius scaling, the device shows a 700‐day lifetime with stable operation in a biofluid at 37 °C. Finally, by measuring the mass of arsenic using an inductively coupled plasma mass spectrometer (ICP/MS), the t‐SiO2 encapsulation barrier is capable of preventing toxic elements from leaching out to surrounding tissues. The technology may provide approaches based on III–V materials for expanding high‐performance optoelectronic devices to biomedical implants, namely, a broad range of high‐resolution retinal prostheses for blindness or the integration for measuring physiological parameters, such as tissue oxygenation and neural activity in the cerebral cortex.

Purpose Mechanical thrombectomy using the stent-retriever in conjunction with the distal access catheter may improve the rates of successful revascularization and clinical outcomes in patients with acute stroke. We aimed to compare two different thrombectomy techniques, according to the position of the distal access catheter tip in the combined stent-retriever and aspiration approach. Methods In this retrospective study, patients with middle cerebral artery occlusion treated with the combined technique were divided into two groups based on the tip position of the distal access catheter: distal group (catheter placed adjacent to the thrombus) and proximal group (catheter placed in the cavernous segment of the internal carotid artery below the ophthalmic artery). Baseline characteristics, angiographic results, and clinical outcomes were compared. Results Eighty-three patients (distal group, n = 45; proximal group, n = 38) were included. Higher complete reperfusion was observed in the distal group (unweighted analysis: 66.7% vs. 42.1%, p = 0.025; weighted analysis: 74.0% vs. 28.8%; p = 0.002). In the multivariate analysis, the distal tip position was independently associated with complete reperfusion (unweighted analysis: aOR, 4.10; 95% CI, 1.40–11.98; p = 0.01; weighted analysis: aOR, 5.20; 95% CI, 1.72–15.78; p = 0.004). The distal group also showed more favorable clinical outcomes and early neurological improvement (unweighted analysis: 62.2% vs. 55.3%; p = 0.521, 60% vs. 50%; p = 0.361, respectively; weighted analysis: 62.7% vs. 61.1%; p = 0.877, 66% vs. 45.7%; p = 0.062, respectively). However, more arterial dissections were observed in the distal group (8.9%, n = 4 vs. 2.6%, n = 1; p = 0.36). In the distal group, one patient with vascular injury died due to complications. No cases of emboli in new territory were observed. Conclusions Distal tip position of the distal access catheter has a significant impact on reperfusion in patients with acute ischemic stroke. However, there was also a higher rate of vascular injury as the catheter was advanced further. If advancement to the target lesion is too difficult, placing it in the cavernous internal carotid artery may be a viable method without complications.

The two distinct types of axonal degeneration that occur after neuronal injury include Wallerian degeneration (WD) and transneuronal degeneration. The most commonly recognizable cause of secondary degeneration is cerebral infarction, but may also include a variety of conditions including hemorrhage, trauma, necrosis, and focal demyelination. Herein, we present a rare case of WD of the cerebellar peduncles accompanied by unilateral hypertrophic olivary degeneration following pontine hemorrhage.

Abstract Background Finding common molecular interactions from different samples is essential work to understanding diseases and other biological processes. Coexpression networks and their modules directly reflect sample-specific interactions among genes. Therefore, identification of common coexpression network or modules may reveal the molecular mechanism of complex disease or the relationship between biological processes. However, there has been no quantitative network comparison method for coexpression networks and we examined previous methods for other networks that cannot be applied to coexpression network. Therefore, we aimed to propose quantitative comparison methods for coexpression networks and to find common biological mechanisms between Huntington’s disease and brain aging by the new method. Results We proposed two similarity measures for quantitative comparison of coexpression networks. Then, we performed experiments using known coexpression networks. We showed the validity of two measures and evaluated threshold values for similar coexpression network pairs from experiments. Using these similarity measures and thresholds, we quantitatively measured the similarity between disease-specific and aging-related coexpression modules and found similar Huntington’s disease-aging coexpression module pairs. Conclusions We identified similar Huntington’s disease-aging coexpression module pairs and found that these modules are related to brain development, cell death, and immune response. It suggests that up-regulated cell signalling related cell death and immune/ inflammation response may be the common molecular mechanisms in the pathophysiology of HD and normal brain aging in the frontal cortex.

BackgroundHuman endogenous retroviruses (HERV) comprise 8% of the human genome and can be classified into at least 31 families. Increased levels of transcripts from the W and H families of HERV have been observed in association with human diseases, such as multiple sclerosis and schizophrenia. Although HERV transcripts have been detected in many tissues and cell-types based on microarray and PCR studies, the extent of HERV expression in different cell-types and diseases state has been less comprehensively studied.ResultsWe examined overall transcription of HERV, and particularly of HERV-W and HERV-H elements in human postmortem brain samples obtained from individuals with psychiatric diagnoses (n = 111) and healthy controls (n = 51) by analyzing publicly available RNA sequencing datasets. Sequence reads were aligned to prototypical sequences representing HERV, downloaded from Repbase. We reported a consistent expression (0.1~0.2% of mappable reads) of different HERV families across three regions of human brains. Spearman correlations revealed highly correlated expression levels between three brain regionsacross 475 consensus sequences. By mapping sequences that aligned to the consensus sequences of HERV-W and HERV-H families to individual loci on chromosome 7, more than 60 loci from each family were identified, part of which are being transcribed. The ERVWE1, locus located at chr7q21.2, exhibited high levels of transcription across the three datasets. Notably, we demonstrated a trend of increased expression of overall HERV, as well as HERV-W family in samples from both schizophrenia and bipolar disorder patients.ConclusionsThe current analyses indicate that RNA sequencing is a useful approach for investigating global expression of repetitive elements, such as HERV, in the human genome. HERV-W/H with the tendency of transcription up-regulation in patients suggests potential implication of HERV-W/H in psychiatric diseases.

The realization of a silicon optical phase shifter marked a cornerstone for the development of silicon photonics, and it is expected that optical interconnects based on the technology relax the explosive datacom growth in data centers. High-performance silicon optical modulators and switches, integrated into a chip, play a very important role in optical transceivers, encoding electrical signals onto the light at high speed and routing the optical signals, respectively. The development of the devices is continuously required to meet the ever-increasing data traffic at higher performance and lower cost. Therefore, heterogeneous integration is one of the highly promising approaches, expected to enable high modulation efficiency, low loss, low power consumption, small device footprint, etc. Therefore, we review heterogeneously integrated optical modulators and switches for the next-generation silicon photonic platform.

Purpose The purpose of this study was to identify common underlying etiologies that may be responsible for isolated acute nontraumatic cortical subarachnoid hemorrhage (cSAH) by analysis of magnetic resonance imaging (MRI) findings of the brain. Materials and Methods From August 2005 to February 2014, 15 cSAH patients were admitted to our institution. All patients with cSAH underwent brain MRI and magnetic resonance angiography as a part of their initial evaluation. An analysis of the patients' medical history, clinical presentations, and brain MRI findings was retrospectively performed. Results Among the combined pathologies that were suspected causes of cSAH, 11 patients showed acute or subacute cerebral infarctions at the ipsilateral hemisphere of cSAH on the diffusion-weighted images. Four of 11 patients had only cerebral infarction, but the other 7 had combined vasculopathy of extra- and intracranial arteries. Four of 15 patients who did not have cerebral infarction, had intracranial artery stenosis, or showed possible cerebral amyloid angiopathy, or no abnormal findings on the brain MRI. Conclusion Ischemic stroke, such as cerebral infarction or vasculopathy of the extraand intracranial arteries is regarded as a common underlying etiology of the cSAH based on MRI findings.

We demonstrated ultra-thin-body (UTB) junctionless (JL) p-type field-effect transistors (pFETs) on Si using GaAs channels. Wafer bonding and epitaxial lift-off techniques were employed to fabricate the UTB p-GaAs-on-insulator on a Si template. Subsequently, we evaluated the JL FETs having different p-GaAs channel thicknesses considering both maximum depletion width and doping concentration for high performance. Furthermore, by introducing a double-gate operation, we more effectively controlled threshold voltage and attained an even higher ION/IOFF of >106, as well as a low subthreshold swing value of 300 mV/dec.

In this study, cavitation flow of hydrofoils is numerically investigated to characterize the effects of turbulence models on cavitation-flow patterns and the corresponding radiated sound waves. The two distinct flow conditions are considered by varying the mean flow velocity and angle of attack, which are categorized under the experimentally observed unstable or stable cavitation flows. To consider the phase interchanges between the vapor and the liquid, the flow fields around the hydrofoil are analyzed by solving the unsteady compressible Reynolds-averaged Navier–Stokes equations coupled with a mass-transfer model, also referred to as the cavitation model. In the numerical solver, a preconditioning algorithm with dual-time stepping techniques is employed in generalized curvilinear coordinates. The following three types of turbulence models are employed: the laminar-flow model, standard k − ε turbulent model, and filter-based model. Hydro-acoustic field formed by the cavitation flow of the hydrofoil is predicted by applying the Ffowcs Williams and Hawkings equation to the predicted flow field. From the predicted results, the effects of the turbulences on the cavitation flow pattern and radiated flow noise are quantitatively assessed in terms of the void fraction, sound-pressure-propagation directivities, and spectrum.

In this study, cavitation flow around a hydrofoil and its radiated hydro-acoustic fields were numerically investigated, with an emphasis on the effects of viscous flux vectors. The full three-dimensional unsteady compressible Reynolds-averaged Navier–Stokes equations were numerically solved. The mass transfer model was adopted to model phase changes between liquid water and vapor. To resolve the numerical instability problem arising from the rapid changes in local density and speed of sound of the mixture, the preconditioning and dual-time stepping methods were employed. The filter-based turbulent model was applied to resolve the unstable cavitation flow field more accurately. In splitting the viscous terms, three approaches for dealing with viscous flux vectors were considered: the so-called viscous lagging, full viscous, and thin-layer models. Radiated hydro-acoustic waves were predicted by applying the Ffowcs Williams and Hawkings equations. The effects of the viscous flux vectors on the predicted flow fields and its radiated noise were then examined by comparing the hydro-dynamic forces, velocity distribution, volume fraction, far-field sound directivities, and sound spectrum of the three approaches. The results revealed that the thin-layer model can provide predictions as accurate as the full viscous model, but required less computational time.

Importance: Glutamic acid decarboxylase 67 (GAD67) is a gamma-aminobutyric acid (GABA) synthesis enzyme associated with the function of other neurotransmitter receptors, such as the N-methyl-D-aspartate (NMDA) receptor and cannabinoid receptor 1. However, the role of GAD67 in the development of different abused drug-induced reward behaviors remains unknown. In order to elucidate the mechanisms of substance use disorder, it is crucial to study changes in biomarkers within the brain's reward circuit induced by drug use. Objective: The study was designed to examine the effects of the downregulation of GAD67 expression in the dorsal striatum on reward behavior development. Methods: We evaluated the effects of GAD67 knockdown on depression-like behavior and anxiety using the forced swim test and elevated plus maze test in a mouse model. We further determined the effects of GAD67 knockdown on ketamine- and JWH-018-induced conditioned place preference (CPP). Results: Knockdown of GAD67 in the dorsal striatum of mice increased depression-like behavior, but it decreased anxiety. Moreover, the CPP score on the NMDA receptor antagonist ketamine was increased by GAD67 knockdown, whereas the administration of JWH-018, a cannabinoid receptor agonist, did not affect the CPP score in the GAD67 knockdown mice group compared with the control group. Conclusions and Relevance: These results suggest that striatal GAD67 reduces GABAergic neuronal activity and may cause ketamine-induced NMDA receptor inhibition. Consequently, GAD67 downregulation induces vulnerability to the drug reward behavior of ketamine. [ABSTRACT FROM AUTHOR]

Knowledge of the venous anatomy is essential for appropriately treating dural arteriovenous fistulas (AVFs). It is challenging to determine the overall venous structure despite performing selective angiography for dural AVFs with feeder from multiple selected arteries. This is because only a part of the veins can be observed through the shunt in the selected artery. Therefore, after performing selective angiography of all vessels to understand the approximate venous anatomy, the venous anatomy can be easily understood by closely examining the source image of computed tomographic angiography or magnetic resonance angiography. Through this, it is possible to specify the vein that is to be blocked (target embolization), thereby avoiding extensive blocking of the vein and avoiding various complications. In the case of dural AVF with feeder from single selected artery, if the multiplanar reconstruction image of the three-dimensional rotational computed tomography obtained by performing angiography is analyzed thoroughly, a shunted pouch can be identified. If embolization is performed by targeting this area, unnecessary sinus total packing can be avoided. [ABSTRACT FROM AUTHOR]